CO2017010382A2 - Métodos de reparación y regeneración tisular - Google Patents

Métodos de reparación y regeneración tisular

Info

Publication number
CO2017010382A2
CO2017010382A2 CONC2017/0010382A CO2017010382A CO2017010382A2 CO 2017010382 A2 CO2017010382 A2 CO 2017010382A2 CO 2017010382 A CO2017010382 A CO 2017010382A CO 2017010382 A2 CO2017010382 A2 CO 2017010382A2
Authority
CO
Colombia
Prior art keywords
site
lesion
induces
tissue repair
cells
Prior art date
Application number
CONC2017/0010382A
Other languages
English (en)
Inventor
Yujian James Kang
Original Assignee
Innolife Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innolife Co Ltd filed Critical Innolife Co Ltd
Publication of CO2017010382A2 publication Critical patent/CO2017010382A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La divulgación proporciona el suministro local de un elemento traza en un sitio de daño tisular, que desencadena el mecanismo de reparación tisular inherente del cuerpo. El suministro local de cobre en el sitio de la lesión induce la migración (es decir, la migración dirigida) de células madre hacia el sitio de la lesión, desencadena la diferenciación de células madre en el sitio de la lesión, induce la regeneración tisular en el sitio de la lesión, induce moléculas de señalización que desencadenan la regeneración tisular, revierte el daño en el sitio de la lesión y/o reconstruye el microambiente de células neurofibrilares y células neurosecretoras en el sitio de la lesión. En otro aspecto, se desvela el suministro de un elemento traza (por ejemplo, cobre) directamente en el sitio de la lesión y los métodos asociados.
CONC2017/0010382A 2015-04-22 2017-10-11 Métodos de reparación y regeneración tisular CO2017010382A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2015/077136 WO2016168993A1 (en) 2015-04-22 2015-04-22 Methods of tissue repair and regeneration
PCT/CN2016/078873 WO2016169416A1 (en) 2015-04-22 2016-04-08 Methods of tissue repair and regeneration

Publications (1)

Publication Number Publication Date
CO2017010382A2 true CO2017010382A2 (es) 2018-01-05

Family

ID=57142823

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0010382A CO2017010382A2 (es) 2015-04-22 2017-10-11 Métodos de reparación y regeneración tisular

Country Status (25)

Country Link
US (1) US11077138B2 (es)
EP (1) EP3285782B1 (es)
JP (2) JP6895388B2 (es)
KR (2) KR20170137919A (es)
CN (1) CN107921062B (es)
AU (1) AU2016250971B2 (es)
BR (1) BR112017022355A2 (es)
CA (1) CA2982840C (es)
CL (1) CL2017002600A1 (es)
CO (1) CO2017010382A2 (es)
DK (1) DK3285782T3 (es)
EA (1) EA038598B1 (es)
EC (1) ECSP17068922A (es)
ES (1) ES2898655T3 (es)
HK (2) HK1247825A1 (es)
HU (1) HUE056650T2 (es)
IL (1) IL255116B (es)
MX (1) MX2017013122A (es)
MY (1) MY189322A (es)
NZ (1) NZ736516A (es)
PE (1) PE20180240A1 (es)
SG (1) SG11201708431QA (es)
TW (1) TWI702956B (es)
UA (1) UA124332C2 (es)
WO (2) WO2016168993A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016168993A1 (en) 2015-04-22 2016-10-27 Innolife Co., Ltd. Methods of tissue repair and regeneration
WO2017049529A1 (en) 2015-09-24 2017-03-30 Innolife Co., Ltd. A pharmaceutical composition comprising a copper chelating tetramine and the use thereof
CN106754662B (zh) * 2016-11-21 2019-11-12 中国人民解放军军事医学科学院基础医学研究所 心肌细胞的制备方法
TWI615127B (zh) * 2017-01-17 2018-02-21 正崴精密工業股份有限公司 計算血壓的方法及其裝置
US20200197318A1 (en) * 2017-05-22 2020-06-25 The Regents Of The University Of California Micro/nanobubble solutions for tissue preservation and generation thereof
TWI634528B (zh) * 2017-08-29 2018-09-01 國立臺北商業大學 用於評估認知能力的電腦程式產品
TWI635469B (zh) * 2017-08-29 2018-09-11 國立臺北商業大學 用於反應力訓練的電腦程式產品
KR102121417B1 (ko) * 2018-10-08 2020-06-10 가천대학교 산학협력단 Stat3 활성화제를 이용한 골격근세포 분화 유도용 조성물 및 이를 이용한 골격근세포 분화 유도 방법
CN109513037B (zh) * 2018-11-14 2021-09-17 华中科技大学同济医学院附属协和医院 一种负载介孔生物玻璃的小肠粘膜下层创面敷料
US20220176011A1 (en) * 2019-02-18 2022-06-09 Lankenau Institute For Medical Research Scar reducing wound closure materials
CN110288581B (zh) * 2019-06-26 2022-11-04 电子科技大学 一种基于保持形状凸性水平集模型的分割方法
AU2021409576A1 (en) * 2020-12-22 2023-07-13 Fluidx Medical Technology, Inc. In situ solidifying injectable compositions with transient contrast agents and methods of making and using thereof
WO2023039353A2 (en) * 2021-09-08 2023-03-16 The Board Of Trustees Of The University Of Illinois Real-time super-resolution ultrasound microvessel imaging and velocimetry
CN114010163B (zh) * 2021-12-02 2023-12-19 中国中医科学院医学实验中心 基于光学成像的表皮细胞迁移定位系统及方法
CN114469897B (zh) * 2022-01-12 2023-02-28 上海市胸科医院 靶向治疗心肌梗死的锂皂石复合递送材料及其制备与应用
CN115177786A (zh) * 2022-07-14 2022-10-14 山东大学 一种原位负载蒙脱土/纳米羟基磷灰石的壳聚糖复合支架材料及其制备方法
CN117547554B (zh) * 2024-01-12 2024-05-14 山东康根源生物集团有限公司 一种间充质干细胞修复制剂及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
JPH03297475A (ja) * 1990-04-16 1991-12-27 Ken Ishihara 共振音波により薬物の放出を制御する方法
US5558082A (en) 1995-01-09 1996-09-24 Spencer; Robert F. Method of intubating a patient and introducer for use with such method
CA2248158A1 (en) 1996-03-12 1997-09-18 The Board Of Regents Of The University Of Nebraska Targeted site specific drug delivery compositions and method of use
US6896659B2 (en) 1998-02-06 2005-05-24 Point Biomedical Corporation Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
GB9826658D0 (en) 1998-12-03 1999-01-27 Univ London Tissue repair
SK16182003A3 (sk) * 2001-06-12 2004-05-04 Cellomeda Oy Porézny hubovitý celulózový materiál na ošetrenie zranení
JP2006503014A (ja) * 2002-08-20 2006-01-26 プロテミックス コーポレイション リミティド 剤形及び関連する治療法
CN1688301A (zh) 2002-08-20 2005-10-26 普罗特米克斯公司 药物剂型及相关的治疗用途
KR20140013078A (ko) 2004-11-07 2014-02-04 쿠프론 인코포레이티드 상처, 화상 및 다른 피부 질환을 치료하기 위한 구리 함유 물질
US20070048387A1 (en) 2005-09-01 2007-03-01 Edwards Jeffrey D Tissue disruption treatment and composition for use thereof
MX2009004776A (es) 2006-11-03 2009-07-14 Multiple Sclerosis Res Ct Of N Celulas madre mesenquimaticas derivadas de medula osea como una fuente de progenitores neurales.
US8481066B2 (en) 2009-07-16 2013-07-09 The Curators Of The University Of Missouri Scaffold for tissue regeneration in mammals
US8287896B2 (en) * 2010-01-06 2012-10-16 The Curators Of The University Of Missouri Scaffolds with trace element for tissue regeneration in mammals
JP5721712B2 (ja) * 2009-07-16 2015-05-20 ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリＴｈｅ Ｃｕｒａｔｏｒｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｓｓｏｕｒｉ 哺乳類の組織再生用の微量元素含有スキャフォールド
CN102302507B (zh) * 2010-07-12 2014-02-05 四川大学华西医院 定向控释微量元素的药物组合物及制备方法和应用
CN101926821B (zh) * 2010-07-12 2012-01-25 四川大学华西医院 一种靶向释放微量元素的药物组合物及制备方法和应用
EP2681196B1 (en) 2011-03-04 2015-09-09 Life Technologies Corporation Compounds and methods for conjugation of biomolecules
JP5598864B2 (ja) * 2011-12-05 2014-10-01 北海道公立大学法人 札幌医科大学 細胞増殖方法ならびに組織の修復および再生のための医薬
CN103467578B (zh) * 2012-06-08 2015-07-08 四川大学华西医院 一种短肽、载铜纳米生物材料及在制备治疗脑梗死的药物中的应用
WO2014027474A1 (ja) * 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
KR101628586B1 (ko) 2012-08-28 2016-06-08 (주)오리지날 바이오메디칼스 킬레이트 복합 교질입자로 구성된 의약 조성물의 제어방출방법
EP2961433A4 (en) 2013-02-28 2016-11-30 Univ Ramot PEPTIDE-BASED HYDROGEL PARTICLES AND USES THEREOF
CN105753719B (zh) 2014-12-17 2019-06-21 四川科瑞德凯华制药有限公司 一种盐酸曲恩汀化合物
WO2016168993A1 (en) 2015-04-22 2016-10-27 Innolife Co., Ltd. Methods of tissue repair and regeneration
WO2017049529A1 (en) 2015-09-24 2017-03-30 Innolife Co., Ltd. A pharmaceutical composition comprising a copper chelating tetramine and the use thereof

Also Published As

Publication number Publication date
KR20170137919A (ko) 2017-12-13
WO2016169416A1 (en) 2016-10-27
JP6895388B2 (ja) 2021-06-30
JP2018520090A (ja) 2018-07-26
AU2016250971B2 (en) 2021-04-29
AU2016250971A1 (en) 2017-11-02
CA2982840A1 (en) 2016-10-27
ES2898655T3 (es) 2022-03-08
MY189322A (en) 2022-02-04
BR112017022355A2 (pt) 2018-07-10
DK3285782T3 (da) 2021-12-06
UA124332C2 (uk) 2021-09-01
EP3285782A4 (en) 2018-12-12
IL255116A0 (en) 2017-12-31
US11077138B2 (en) 2021-08-03
EP3285782A1 (en) 2018-02-28
TWI702956B (zh) 2020-09-01
TW201642876A (zh) 2016-12-16
EA038598B1 (ru) 2021-09-21
EP3285782B1 (en) 2021-09-08
EA201792307A1 (ru) 2018-06-29
CA2982840C (en) 2022-10-25
HK1247825A1 (zh) 2018-10-05
KR20200000458A (ko) 2020-01-02
CL2017002600A1 (es) 2018-03-23
MX2017013122A (es) 2018-06-18
PE20180240A1 (es) 2018-01-31
NZ736516A (en) 2019-04-26
SG11201708431QA (en) 2017-11-29
WO2016168993A1 (en) 2016-10-27
US20180099008A1 (en) 2018-04-12
JP2020143158A (ja) 2020-09-10
CN107921062B (zh) 2021-03-02
ECSP17068922A (es) 2018-02-28
CN107921062A (zh) 2018-04-17
IL255116B (en) 2020-10-29
HK1251181A1 (zh) 2019-01-25
HUE056650T2 (hu) 2022-02-28
KR102347010B1 (ko) 2022-01-04

Similar Documents

Publication Publication Date Title
CO2017010382A2 (es) Métodos de reparación y regeneración tisular
DOP2019000005A (es) 3-metil pirazinas 2,5-disustituidas y 3-metil pirazinas 2,5,6-trisustituidas como inhibidores alostéricos de shp2
CL2021000039A1 (es) Moléculas de anticuerpo que se unen a cd73 y usos de las mismas (divisional solicitud 201903796)
CL2017002066A1 (es) Proteasas de cisteína
CL2015002443A1 (es) Péptidos y composiciones para el tratamiento del daño articular
UY37124A (es) Nuevos compuestos de 6,7-dihidro-5h-benzo[7]anuleno sustituidos, procesos para su preparación y usos terapéuticos de los mismos
CL2017000521A1 (es) Inhibidores de desmetilasa-1 específica a lisina
PE20180260A1 (es) Metodos y kits para tratar la depresion
SV2017005373A (es) Inhibidores de la proteína quinasa c y métodos de su uso
CR20150648A (es) Derivados de nucleósido 4´-azido, 3´-desoxi-3´-fluoro sustituido
ECSP20046463A (es) Compuestos, composiciones y métodos para tratar enfermedades que involucren tejidos con enfermedades ácidas o hipóxicas
UY32551A (es) Compuestos peptidomiméticos de sulfamida y usos antivirales de los mismos
UY32554A (es) Compuestos peptidomiméticos de sulfonamida y usos antivirales de los mismos
AR096672A1 (es) Compuestos de tipo estrobilurina para combatir hongos fitopatogénicos
MX2020004837A (es) Inhibidores de la vía de adenosina para el tratamiento del cáncer.
AR092899A1 (es) Uso de masitinib para el tratamiento del cancer en subpoblaciones de pacientes identificados que utilizan factores de prediccion
CL2016000597A1 (es) Derivados de desoxino jirimicina y sus métodos de uso.
CR20160316A (es) Compuestos derivados de hidroxiformamida y usos del mismo
BR112018014590A2 (pt) formulações/composições compreendendo um inibidor de btk
UY36373A (es) Compuestos para usarse en el tratamiento antihelmíntico
CL2021000329A1 (es) Compuestos útiles en terapia del vih
CO2020001107A2 (es) Moduladores terapéuticos del modo inverso de la atp sintasa
BR112015029145A2 (pt) Usos de um domínio extracelular (ecd) de receptor de fator de crescimento de fibroblastos 1 (fgfr1) e métodos de identificação de pacientes
CL2019000027A1 (es) Regímenes de dosificación de antagonistas de la lingo-1 y usos para el tratamiento de los trastornos desmielinizantes.
ES1165083Y (es) Dispositivo para el posicionamiento de pacientes en tratamientos de radioterapia