CN86108273A - The preparation method of Sanguis Draxonis - Google Patents
The preparation method of Sanguis Draxonis Download PDFInfo
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- CN86108273A CN86108273A CN 86108273 CN86108273A CN86108273A CN 86108273 A CN86108273 A CN 86108273A CN 86108273 CN86108273 CN 86108273 CN 86108273 A CN86108273 A CN 86108273A CN 86108273 A CN86108273 A CN 86108273A
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- solution
- feature
- neutralization
- present
- dilute alkaline
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Be directly to gather resin or with alcohol dipping-reflux extraction pharmaceutically with Sanguis Draxonis.The present invention is with the diluted alkaline lixiviate, adds sour neutralization precipitation and separates out, and adds dissolve with ethanol, separation again, concentrates, dry and produce Sanguis Draxonis, claims alkali liquor extraction method.This method can guarantee safety in production, improves the quality of products, and can reduce production costs again, particularly is suitable for ethanol and lacks the area use.
Description
The invention relates to pharmaceutically a kind of preparation method of the Sanguis Draxonis of usefulness.Also be applicable to and obtain through refining other non-water-soluble resin class medicine or highly finished product.
Sanguis Draxonis is a rare medicinal herbs, has effects such as blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, hemostasis.Sanguis Draxonis is in all age by import, and the import Sanguis Draxonis derives from two kinds of Daemonorops plant and dracaena plants, is to gather the natural resin moulding or not moulding forms, all without obtaining through refining.
Also there is dracaena plant in China, and Guangxi is many especially, and the inventor once proposed " a kind of preparation method of Sanguis Draxonis " (applying date 860728, application number 86105793) before this and promptly uses alcohol dipping-reflux extraction.
The purpose of this invention is to provide the another kind of method-alkali liquor extraction method that extracts Sanguis Draxonis, be that raw material is added in the extraction pot,, leach alkali extracting solution with a certain amount of dilute alkaline soln room temperature or heating lixiviate certain hour, add acid neutralizing filter, precipitation adds dissolve with ethanol solution and filters or centrifugalize.Lysate is concentrated and recovery ethanol, and concentrated solution is drying to obtain product.Be characterized in overcoming the insecurity of ethanol extraction, made production safety reliable, saved organic solvent, product is pure, and it is more suitable to lack the area at ethanol.
See accompanying drawing, it is the process flow diagram of alkali liquor extraction method, wherein:
K
1～K
16Be valve, S
1: alkali liquor, S
3: steam, S
3: compressed air, S
6: ethanol, S
7: acid solution, A: charge door, B: paste outlet, C
1, C
2Slag-drip opening.The 1-extraction pot, 2-neutralization, dissolving tank, 3-concentration tank, 5-hold-up tank.
The technical process of alkali liquor extraction method is such:
(1) the raw material coarse powder is added in the extraction pot 1 open valve K by charge door A
1Add a certain amount of dilute alkaline soln S
1, shut off valve K
1
(2) room temperature lixiviate certain hour or open valve K
3Logical steam S
3To jar 1 solution, heat lixiviate certain hour shut off valve K
3
(3) open valve K
2, K
14, K
4, compressed air S
3Make whole alkali liquor enter in neutralization, the dissolving tank 2 shut off valve K by jar 1 bottom screen
2, K
14, K
4
(4) open valve K
3, add the acid solution neutralization gradually, be stirred to precipitation at normal temperatures and separate out or open valve K
7Logical steam stirs to jar 2 and constantly, separates out shut off valve K to precipitating
5, K
7, stop to stir.
(5) open valve K
8, K
15, K
18, add compressed air S
5, make whole neutralizers pass through jar 2 bottom screen through K
18Discharge, close K
8, K
15, K
18
(6) open valve K
6Add a certain amount of ethanol S
6, shut off valve K
6, stirring fully dissolves it, stops to stir.
(7) open valve K
8, K
15, K
9, add compressed air S
5Make whole alcoholic solution pass through jar 2 bottom screen to concentration tank 3, shut off valve K
8, K
15, K
9; Open valve K
12Feed steam, pressurization or open valve K
10Concentrating under reduced pressure and open valve K
11, K
13Reclaim ethanol to hold-up tank 5, shut off valve K when the alcoholic solution to concentration tank 3 is thick paste
12, K
11, K
13
(8) open valve K
10B emits thick paste through paste outlet, promptly gets product-Sanguis Draxonis after the drying.
After finish (3), add a certain amount of dilute alkaline soln again to extraction pot 1, by (2) to (7) method operation, like this repetitive operation several times, jar 1 is by C
1Deslagging, jar 2 is by C
2Deslagging connects by (8) operation, and the one-time process flow process promptly finishes like this.
Describe in detail below by an embodiment:
See accompanying drawing, (1) adds the raw material coarse powder in the extraction pot 1 by charge door A, open valve K
1Adding is 10～30: 1 with the ratio (weight) of raw material, and concentration is 0.1%～1.0% aqueous slkali, as NaOH solution or KOH solution or Na
2CO
3Solution, shut off valve K
1(2) room temperature lixiviate 10-60 minute or open valve K
3Feed steam to extraction pot 1 solution, with (not comprising room temperature) heating lixiviate in the scope of room temperature or room temperature～100 ℃ 10-60 minute, shut off valve K
3(3) open valve K
2, K
14, K
4, add compressed air S
5Whole alkali liquor are entered in neutralization, the dissolving tank 2 by extraction pot 1 bottom screen, close K
2, K
14, K
4(4) open valve K
5, add acid solution gradually, as HCl solution or the neutralization of HAC solution, constantly be stirred to precipitation at normal temperatures and separate out or open valve K
7Logical steam is gone in neutralization, the dissolving tank 2, (does not comprise room temperature) and stir to ℃ scope of room temperature～100, separates out shut off valve K until precipitation
5, K
7, stop to stir.(5) open valve K
3, K
15, K
18, add compressed air S
5, make whole neutralizers pass through neutralization, dissolving tank 2 bottom screen through valve K
18Discharge, close K
8, K
15, K
18(6) open valve K
6Add precipitation: ethanol (weight) 1: 5～15 concentration are the alcoholic solution more than 80%, shut off valve K
6, stir it is fully dissolved after, stop to stir.(7) open valve K
8, K
15, K
9, by valve K
8Add compressed air S
5, make whole alcoholic solution pass through in and dissolving tank 2 bottom screen to concentration tank 3, shut off valve K
8, K
15, K
9; Open valve K
12Feed steam pressurized or open valve K
10Decompression and open valve K
11, K
13, reclaim ethanol to hold-up tank 5, make shut off valve K when alcoholic solution is the thick paste shape in jars 3
12, K
11, K
13(8) open valve K
16B emits thick paste by paste outlet, and drying can get Sanguis Draxonis.
After each step (3) operation is finished, add a certain amount of NOH solution or KOH solution or Na again
2CO
3Solution repeats 3 times by (2) to (7) step to extraction pot 1.Each adding dilute alkaline soln is respectively 5～15 with the ratio (proportion) of raw material: 1,5～15: 1,5～15: 1, technological process of the present invention is periodic, before following one-period will begin, goes out the waste residue in last cycle earlier.
Claims (7)
1, pharmaceutically the Sanguis Draxonis of usefulness is without obtaining through refining or obtaining with alcohol dipping-reflux extraction, and feature of the present invention is to extract with dilute alkaline soln, adds sour neutralization precipitation and separates out, and with alcoholic solution separation and Extraction Sanguis Draxonis, is called alkali liquor extraction method.
2, according to claim 1, feature of the present invention is that said alkali liquor extraction method is that raw material is added extraction pot 1, filter pressing is gone in neutralization, the dissolving tank 2 after adding a certain amount of dilute alkaline soln room temperature or heating lixiviate certain hour, adding the acid solution neutralization usually separates out, neutralizer is discharged in filter pressing, filtering residue adds a certain amount of dissolve with ethanol, the lysate filter pressing is concentrated to concentration tank 3, reclaim ethanol simultaneously, the a certain amount of dilute alkaline soln lixiviate of filtering residue reuse in the extraction pot 1, neutralization dissolving and concentrated, repeat several times, emit concentrated solution and promptly get product after drying.
3, as described in the claim 1,2, feature of the present invention is that said adding dilute alkaline soln is 0.1% to 1.0% NaOH solution or KOH solution or Na
2CO
3Solution.
4, as described in the claim 2,3, feature of the present invention is that the ratio (weight) of dilute alkaline soln and raw material in the above-mentioned said adding extraction pot 1 is 10～30: 1, filtering residue repeats lixiviate, neutralization, dissolving and concentrates 3 times, and every ratio (weight) that repeats once to add above-mentioned said dilute alkaline soln and raw material is respectively 5～15: 1,5～15: 1,5～15: 1.
5, as described in the claim 2, feature of the present invention is that said room temperature or heating lixiviate certain hour are meant in the scope of room temperature or room temperature～100 ℃ lixiviate 10-60 minute.
6, as described in the claim 2, feature of the present invention is to add the acid solution neutralization to be meant with HCl solution or HAc solution.
7, as described in the claim 2, feature of the present invention is saidly to add a certain amount of alcoholic solution and be meant that concentration is that the ratio (weight) of industrial alcohol solution and precipitate more than 80% is 5～15: 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 86108273 CN86108273A (en) | 1986-12-15 | 1986-12-15 | The preparation method of Sanguis Draxonis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 86108273 CN86108273A (en) | 1986-12-15 | 1986-12-15 | The preparation method of Sanguis Draxonis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN86108273A true CN86108273A (en) | 1988-07-06 |
Family
ID=4803861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 86108273 Pending CN86108273A (en) | 1986-12-15 | 1986-12-15 | The preparation method of Sanguis Draxonis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN86108273A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096852C (en) * | 2000-01-21 | 2002-12-25 | 广东名盛药业有限公司 | Resina Draconis preparation as one Chinese medicine and its preparation process |
| CN100391513C (en) * | 2004-08-31 | 2008-06-04 | 桂林三金药业股份有限公司 | Medicinal preparation for treating cardio and cerebral vascular disease and its preparation method and quality control method |
| CN108853299A (en) * | 2018-07-12 | 2018-11-23 | 云南茶农生物产业有限责任公司 | A kind of extracting method of dragon's blood |
-
1986
- 1986-12-15 CN CN 86108273 patent/CN86108273A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096852C (en) * | 2000-01-21 | 2002-12-25 | 广东名盛药业有限公司 | Resina Draconis preparation as one Chinese medicine and its preparation process |
| CN100391513C (en) * | 2004-08-31 | 2008-06-04 | 桂林三金药业股份有限公司 | Medicinal preparation for treating cardio and cerebral vascular disease and its preparation method and quality control method |
| CN108853299A (en) * | 2018-07-12 | 2018-11-23 | 云南茶农生物产业有限责任公司 | A kind of extracting method of dragon's blood |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |