CN85103760A - Sodium starch glycolate and contain the manufacture method of the preparation of this material - Google Patents
Sodium starch glycolate and contain the manufacture method of the preparation of this material Download PDFInfo
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- CN85103760A CN85103760A CN 85103760 CN85103760A CN85103760A CN 85103760 A CN85103760 A CN 85103760A CN 85103760 CN85103760 CN 85103760 CN 85103760 A CN85103760 A CN 85103760A CN 85103760 A CN85103760 A CN 85103760A
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- starch glycolate
- sodium starch
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Abstract
Starch promptly carries out carboxymethylation, through water-soluble Jie after being hydrolyzed in containing sodium hydroxide and chloroacetic solution in the acidic aqueous solution that contains alcohol, purifying is filtered in decolouring, drying step promptly makes substitution value scope 0.2-1.0, the sodium starch glycolate of limiting viscosity 10-100 milliliter/gram.This sodium starch glycolate can be mixed with through proper method, and the preparation of treatment repeated respiratory tract infections in children and allergic asthma is as injection liquid, syrup, pulvis etc.
Description
The present invention is a kind of manufacture method for the treatment of the carboxymethyl starch sodium preparation that disease uses, this method comprises from the method for Starch Production sodium starch glycolate, and prepare the method that contains carboxymethyl starch sodium preparation, said preparation can be used for treating recurrent respiratory tract infection and allergic asthma.Anaphylactoid purpura, chronic diarrhoea etc. is also had certain curative effect, is a kind of good immune function controlling agents.
In pediatric disease, recurrent respiratory tract infection and allergic asthma are two kinds of common diseases, and the cause of disease is relevant with immunologic function.If treat anti-infectives and suppressing panting calming medicine that the drug main of these two kinds of diseases takes stopgap measures at present, lack the immunoregulation druge that effects a permanent cure.Therefore the children that suffer from above-mentioned disease are after the general method treatment, though symptom can alleviate to a certain extent or disappearance regular meeting falls ill repeatedly.
The purpose of this invention is to provide and a kind ofly can treat repeated respiratory tract infections in children and allergic asthma, and prevent the production method that contains carboxymethyl starch sodium preparation of its recurrence.
Industrial Preparation of sodium carboxymethy starch generally is with the reaction in containing some organic solvent water-soluble of starch, Mono Chloro Acetic Acid, sodium hydroxide.The sodium starch glycolate .M.CehStaerke24(4 that generates) 124-7, (1972) are at industrial slurry, thickening material, the dispersion agent of can be used as.
The invention provides a kind ofly has the method for the medicinal sodium starch glycolate of special requirement from starch preparation, and it is mixed with the method for treatment disease with preparation.
The production method of sodium starch glycolate of the present invention comprises the starch hydrolysis, steps such as carboxymethylation and purifying.Be specifically described as follows: starch is being contained pure 0-60%(weight) and the heated in water solution of mineral acid 0.01M-1M carry out water and be situated between, temperature is 50 °-100 ℃, the time is 0.2-3.5 hour.Wherein
Alcohol can be methyl alcohol, ethanol, propyl alcohol, Virahol, butanols, isopropylcarbinol etc.Mineral acid can be phosphoric acid, sulfuric acid, hydrochloric acid, nitric acid etc., carboxymethylation is starch and the 50%(weight after water is situated between) sodium hydroxide and 50%(weight) chloroacetic reactant aqueous solution, the mole ratio that feeds intake is respectively a starch: sodium hydroxide: Mono Chloro Acetic Acid=1: 0.3-2: 0.2-1.5, carboxymethylated temperature is 20 °-100 ℃, time is 0.5-4 hour, reactant is separated out with pulpous state, use water-soluble Jie, decolorizing with activated carbon, purifying, in alcohol post precipitation drying, abrasive dust or spray-dried, can get the powdery sodium starch glycolate.
In the production method of sodium starch glycolate of the present invention, recommending the starch hydrolysising condition is to adopt to contain 0-40%(weight) alcohol, the aqueous solution of mineral acid 0.02-0.8M, temperature is 70 °-100 ℃, the time is 0.5-3 hour.The mole ratio that carboxymethylation feeds intake is starch: sodium hydroxide: Mono Chloro Acetic Acid=1: 0.4-1.5: 0.3-1.2.Temperature is 30 °-80 ℃, and the time is 1-3 hour.Use 0.1-2%(weight) activated carbon decolours, in high density alcohol, precipitates, drying, yield is more than 90%.
The sodium starch glycolate that adopts the inventive method to produce has the limiting viscosity of 10-100 milliliter/gram, and the substitution value scope is 0.2-1.0.
The present invention also provides a kind of sodium starch glycolate preparation that makes with aforesaid method to treat the method for the preparation of respiratory tract infection and allergic asthma.As injection liquid, syrup, the preparation of pulvis etc., the more sodium starch glycolate of water content also can be used for preparation after deducting moisture content as calculated.
The invention provides a kind of treatment respiratory tract infection of sodium starch glycolate and injection liquid compound method of allergic asthma of containing: this method comprises the weight with 1-15%() sodium starch glycolate, 0-5%(weight) glucose, 0-0.9(weight) sodium-chlor, 0.1-1%(weight) decolouring activated carbon, all the other are water, after being mixed arbitrarily, being heated to boils filters again through high temperature or millipore filtration sterilization.
The present invention also provides the compound method of the oral syrup of a kind of treatment respiratory tract infection that contains sodium starch glycolate and allergic asthma, be about to 5-70%(weight) the carboxymethyl sugared sodium that forms sediment, 0-50%(weight) sugar, 0.01-0.5%(weight) sanitas, proper amount of edible spices and pigment, all the other are the said components material of water, mix arbitrarily, being heated to boil the sterilization oral syrup.The sugar of wherein preparing usefulness can be glucose, fructose, sucrose, maltose etc.Anticorrosion can be benzoate, sulfurous gas, propionic acid, Sorbic Acid, to hydroxyl methyl-formiate or ethyl ester etc.
The present invention also provides a kind of treatment respiratory tract infection of sodium starch glycolate and pulvis compound method of allergic asthma of containing: with 5-70%(weight) sodium starch glycolate, 0-50%(weight) sugar, all the other mix arbitrarily for the said components of water, carry out spraying drying or oven dry abrasive dust.The sugar of wherein preparing usefulness can be glucose, fructose, sucrose, maltose etc.
Dry powder of the present invention or aqueous sodium starch glycolate also can be mixed with electuary, tablet, and capsule preparations, said preparation is to animal and human's nontoxicity, safe in utilization.Remarkable to the recurrence effect of preventing and treating recurrent respiratory tract infection and allergic asthma, be a kind of immunoregulation druge.
The production of example 1. sodium starch glycolatees
Get starch be uniformly distributed in for 1 part contain 40%(weight) in the aqueous solution of alcohol, the concentration of acid is 0.01N in this solution, Heating temperature is 70 ℃, carries out water and is situated between, the time is 20 minutes.Add 0.4 part of sodium hydroxide stirring heating after the cooling again, add 40 ℃ of 0.5 part of Mono Chloro Acetic Acid, temperature then, 30 minutes time.Add alcohol and isolate the syrup material, be dissolved in water, 0.01 part of activated carbon decolours, filtration, purifying, soup compound with dehydration of alcohols or spraying drying.Soup compound that this method makes or dry powder, the preparation that the various treatment diseases of all available preparation are used.
Example 2, the compound method of injection liquid
Get 10 parts according to example 1 prepared sodium starch glycolate, add 0.9 part of sodium-chlor and 5 parts of glucose, all the other are distilled water, stir evenly heating, add 0.1 part of activated carbon, and temperature is 80 °-100 ℃, filter, high-temperature sterilization or millipore filtration sterilization injection liquid.
Example 3. syrupy compound methods
Get 5 parts according to example 1 gained sodium starch glycolate, add 0.1 part of Sodium Benzoate, 10 parts of sucrose, flavouring agent and pigment are an amount of, all the other are water, stir evenly, be heated to the sterilization of boiling, oral syrup.
Example 4, the compound method of pulvis
Get 20 parts of 10 parts, sucrose according to example 1 obtained sodium starch glycolate, other is a water, stirs evenly, carry out spraying drying, pulvis.
Claims (11)
1, a kind of production method of sodium starch glycolate, this method comprises with Mono Chloro Acetic Acid, aqueous sodium hydroxide solution carries out carboxymethylation, it is characterized in that starch is earlier containing 0-60% (weight) alcohol, the inorganic aqueous acid of 0.01-1M, when temperature is 50 °-100 ℃, be hydrolyzed 0.2-3.5 hour, the direct carboxymethylation of starch after the hydrolysis, product is separated out with pulpous state, uses water-soluble Jie again, decolorizing with activated carbon, purifying, post precipitation drying, abrasive dust or spraying drying in alcohol.
2, by the production method of claim 1 described sodium starch glycolate, it is characterized in that hydrolysising condition is, containing 0-40%(weight) in the alcohol, the inorganic aqueous acid of 0.02-0.8M, when temperature is 70 °-100 ℃, hydrolysis time 0.5-3 hour.
3, by the production method of claim 1 or 2 described sodium starch glycolatees, it is characterized in that alcohol can be methyl alcohol, ethanol, propyl alcohol, Virahol, butanols or isopropylcarbinol.
4, the production method of deciding powder sodium by claim 1 or 2 described carboxymethyls is characterized in that mineral acid can be phosphoric acid, sulfuric acid, hydrochloric acid or nitric acid.
5, by the production method of claim 1 described sodium starch glycolate, the material mole ratio is when it is characterized in that carboxymethylation, starch: sodium hydroxide: Mono Chloro Acetic Acid=1: 0.4-1.5: 0.3-1.2.
6, a kind ofly contain the injection liquid compound method that is used for the treatment of recurrent respiratory tract infection and allergic asthma that useful claim 1 described method makes sodium starch glycolate, it is characterized in that weight with 1-15%() sodium starch glycolate, 0-5%(weight) glucose, 0-0.9%(weight) sodium-chlor, 0.1-1%(weight) the decolouring activated carbon, all the other are deionized water, after mixing arbitrarily, be heated to the filtration of boiling, again through high temperature or millipore filtration sterilization.
7, a kind ofly contain the compounding method of syrup that is used for the treatment of recurrent respiratory tract infection and allergic asthma that useful claim 1 described method makes sodium starch glycolate, it is characterized in that it being) with 5-70%(weight, sodium starch glycolate, 0-50%(weight) sugar, 0.01-0.5%(weight) sanitas, proper amount of edible spices, pigment, all the other are water, mix arbitrarily, be heated to the sterilization of boiling.
8,7 described preparations contain the syrupy method of sodium starch glycolate as claim, and wherein said sugar can be glucose, fructose, sucrose, maltose.
9,7 described preparations contain the syrupy method of sodium starch glycolate as claim, and wherein sanitas can be a benzoate, sulfurous gas, propionic acid, Sorbic Acid, to hydroxyl methyl-formiate or ethyl ester.
10, a kind ofly contain the pulvis compound method that is used for the treatment of recurrent respiratory tract infection and allergic asthma that useful claim 1 described method makes sodium starch glycolate, it is characterized in that weight with 5-70%() sodium starch glycolate, 0-50%(weight) sugar, all the other carry out spraying drying or oven dry abrasive dust after being any mixing of above-mentioned substance of water.
11,10 described preparations contain the method for carboxymethyl shallow lake sodium pulvis as claim, and wherein said sugar can be glucose, fructose, sucrose, maltose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 85103760 CN85103760B (en) | 1985-05-13 | 1985-05-13 | Preparation of sodium caboxymethyl starch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 85103760 CN85103760B (en) | 1985-05-13 | 1985-05-13 | Preparation of sodium caboxymethyl starch |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 87102184 Division CN1024498C (en) | 1987-02-02 | 1987-02-02 | Manufacture method of medicine to cure repeated intection of respiratory tract and asthma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN85103760A true CN85103760A (en) | 1986-11-12 |
| CN85103760B CN85103760B (en) | 1987-07-22 |
Family
ID=4793416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 85103760 Expired CN85103760B (en) | 1985-05-13 | 1985-05-13 | Preparation of sodium caboxymethyl starch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN85103760B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1037105C (en) * | 1994-08-04 | 1998-01-21 | 安徽省生物研究所 | Phase transfer synthetic process for high substitution value sodium carboxymethyl amyloether |
| CN101407554B (en) * | 2008-10-30 | 2011-06-15 | 高莉萍 | Sodium carboxymethylstarch and preparation thereof |
| CN103709258A (en) * | 2013-12-23 | 2014-04-09 | 河南海洋化工有限公司 | Sodium carboxymethyl starch for drilling fluid and preparation method thereof |
-
1985
- 1985-05-13 CN CN 85103760 patent/CN85103760B/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1037105C (en) * | 1994-08-04 | 1998-01-21 | 安徽省生物研究所 | Phase transfer synthetic process for high substitution value sodium carboxymethyl amyloether |
| CN101407554B (en) * | 2008-10-30 | 2011-06-15 | 高莉萍 | Sodium carboxymethylstarch and preparation thereof |
| CN103709258A (en) * | 2013-12-23 | 2014-04-09 | 河南海洋化工有限公司 | Sodium carboxymethyl starch for drilling fluid and preparation method thereof |
| CN103709258B (en) * | 2013-12-23 | 2015-07-08 | 河南海洋化工有限公司 | Sodium carboxymethyl starch for drilling fluid and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN85103760B (en) | 1987-07-22 |
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