CN1024498C - Manufacture method of medicine to cure repeated intection of respiratory tract and asthma - Google Patents
Manufacture method of medicine to cure repeated intection of respiratory tract and asthma Download PDFInfo
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- CN1024498C CN1024498C CN 87102184 CN87102184A CN1024498C CN 1024498 C CN1024498 C CN 1024498C CN 87102184 CN87102184 CN 87102184 CN 87102184 A CN87102184 A CN 87102184A CN 1024498 C CN1024498 C CN 1024498C
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- carboxymethyl starch
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- starch sodium
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- sodium
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Abstract
The present invention belongs to a method for preparing medicine for treating recurrent respiratory tract infection and asthma. For the current treatment of the paediatrics, medicine for treating recurrent respiratory tract infection and allergic asthma is palliative anti-infection medicine and anti-asthmatic, and immune regulating medicine for treating root is lack. The present invention provides a carboxymethyl starch sodium containing preparation and a preparation method for treating recurrent respiratory tract infection and allergic asthma of children and preventing the recurrent respiratory tract infection and allergic asthma from recurring. The preparation has the advantages of nontoxicity of animal and people, safe use, certain therapeutic effect of chronic diarrhea and is a good immunological function regulator.
Description
The invention belongs to the medicine manufacturing of treatment recurrent respiratory tract infection and asthma.This medicine is a preparation of making main composition with carboxymethyl starch sodium.Said preparation is treated recurrent respiratory tract infection and the allergic asthma except can be used for, and also anaphylactoid purpura, chronic diarrhea etc. is had certain curative effect, is a kind of good immune function controlling agents.
Carboxymethyl starch sodium can be used as for blood (" pharmaceutical preparation note ", Gu Xueqiu, P87,1983), and its intrinsic viscosity should be 0.300-0.550, but along not reporting the infection that is used for respiratory tract disease.In pediatric disease, recurrent respiratory tract infection and allergic asthma are two kinds of common diseases, and the cause of disease is relevant with immunologic function.If treat anti-infectives and suppressing panting calming medicine that the drug main of these two kinds of diseases takes stopgap measures at present, lack the immunoregulation medicament that effects a permanent cure.Therefore the child who suffers from above-mentioned disease, after the conventional method treatment, though symptom can alleviate or disappear to a certain extent, regular meeting falls ill repeatedly.
The purpose of this invention is to provide and a kind ofly can treat repeated respiratory tract infections in children and allergic asthma, and prevent the production method that contains carboxymethyl starch sodium preparation of its recurrence.
Medicine provided by the present invention as Main Ingredients and Appearance, is mixed with injection, oral administration solution and powder etc. with a kind of carboxymethyl starch sodium of special requirement.The more carboxymethyl starch sodium of water content also can be used for preparation as calculated with behind the deduction moisture content.
The used carboxymethyl starch sodium of the present invention has the intrinsic viscosity of 10～100 milliliters/gram.The substitution value scope is 0.2～1.0.
The invention provides a kind of treatment respiratory tract infection of carboxymethyl starch sodium and injection production method of allergic asthma of containing: this method comprises the weight with 1～15%() carboxymethyl starch sodium, 0～5%(weight) glucose, 0～0.9%(weight) sodium chloride, 0.1～1%(weight) decolouring activated carbon, all the other are water, behind the mixing, being heated to boils filters again through high temperature or microporous filter sterilization.
The present invention also provides the production method of the oral liquid of a kind of treatment respiratory tract infection that contains carboxymethyl starch sodium and allergic asthma, be about to 5～70%(weight) carboxymethyl starch sodium, 0～50%(weight) sugar, 0.01～0.5%(weight) antiseptic, proper amount of edible spice and pigment, all the other are the said components material of water, arbitrarily mix homogeneously, being heated to boil the sterilization oral liquid, the sugar of wherein preparing usefulness can be glucose, fructose, sucrose, maltose etc.Antiseptic can be benzoate, sulfur dioxide, propanoic acid, mountain plough acid, to hydroxyl methyl formate or ethyl ester etc.
The present invention also provides a kind of treatment respiratory tract infection of carboxymethyl starch sodium and powder production method of allergic asthma of containing: with 5～70%(weight) carboxymethyl starch sodium, 0～50%(weight) sugar, all the other are any mix homogeneously of said components of water, carry out spray drying or oven dry pulverizing.The sugar of wherein preparing usefulness can be glucose, fructose, sucrose, maltose etc.
Carboxymethyl starch sodium is the intrinsic viscosity with 10～100 milliliters/gram in the medicine of the present invention, and substitution value is 0.2～1.0.Its production method comprises the starch hydrolysis, carboxy methylation and purification.Be specifically described as follows: starch is being contained alcohol 0～60%(weight) and the heated in water solution of mineral acid 0.01M-1M be hydrolyzed, temperature is 50 °～100 ℃, time is 0.2～3.5 hour, and wherein alcohol can be methanol, ethanol, propanol, isopropyl alcohol, butanols, isobutanol etc.Mineral acid can be phosphoric acid, sulphuric acid, hydrochloric acid, nitric acid etc.Carboxy methylation is with starch after the hydrolysis and 50%(weight) sodium hydroxide and 50%(weight) chloroacetic reactant aqueous solution.The mole ratio that feeds intake is respectively a starch: sodium hydroxide: monoxone=1: 0.3-2: 0.2-1.5, and carboxymethylated temperature is 20 °～100 ℃, the time is 0.5～4 hour.Reactant is separated out with pulpous state.Use water dissolution, decolorizing with activated carbon, purification, in alcohol post precipitation drying, pulverizing or spray-dried, can get the powdery carboxymethyl starch sodium.
In the production method of carboxymethyl starch sodium of the present invention, recommending the starch hydrolysising condition is to adopt to contain 0～40%(weight) alcohol, the aqueous solution of mineral acid 0.02～0.8M, temperature is 70 °～100 ℃, the time is 0.5～3 hour.The mole ratio that carboxy methylation feeds intake is starch: sodium hydroxide: monoxone=1: 0.4～1.5: 0.3～1.2.Temperature is 30 °～80 ℃, and the time is 1～3 hour.With 0.1～2%(weight) activated carbon decolours, in high concentration alcohol, precipitates, drying, yield is more than 90%.
The carboxymethyl starch sodium that adopts the inventive method to produce has the intrinsic viscosity of 10～100 milliliters/gram.The substitution value scope is 0.2～1.0.
Dry powder of the present invention or aqueous carboxymethyl starch sodium also can be mixed with electuary, tablet, capsule preparations.Adopt medicine of the present invention to animal and human's avirulence, safe in utilization.Remarkable to the recurrence effect of preventing and treating recurrent respiratory tract infection and allergic asthma, be a kind of immunoregulation medicament.
Embodiment
The compound method of example 1. injection
Carboxymethyl starch sodium is got 10 parts, adds 0.9 part of sodium chloride and 5 parts of glucoses, and all the other are distilled water, stir evenly heating, add 0.1 part of activated carbon, and temperature is 80～100 ℃ of filtrations, high temperature sterilize or microporous filter sterilization injection.
The compound method of example 2. oral administration solutions
Carboxymethyl starch sodium is got 5 parts, adds 0.1 part of sodium benzoate, 10 parts of sucrose, flavorant and pigment are an amount of, all the other are water, stir evenly, be heated to the sterilization of boiling, oral administration solution.
The compound method of example 3. powder
Carboxymethyl starch sodium is got 20 parts of 10 parts, sucrose, and all the other are water, stir evenly, carry out spray drying, powder.
The production of example 4. carboxymethyl starch sodium.
Get starch be uniformly distributed in for 1 part contain 40%(weight) alcohol aqueous solution in, in this solution acid concentration be 0.01N, heating-up temperature is 70 ℃, is hydrolyzed, the time is 20 minutes.Add 0.4 part of sodium hydroxide agitating heating after the cooling again, add 40 ℃ of 0.5 part of monoxone, temperature then, 30 minutes time.Add alcohol and isolate the syrup material, be dissolved in water, 0.01 part of activated carbon decolours, filtration, purification, slurry with dehydration of alcohols or spray drying.
Claims (10)
1, a kind of compound method that is used for the treatment of recurrent respiratory tract infection and allergic asthma injection that contains carboxymethyl starch sodium, it is characterized in that 1～15% (weight) is had the carboxymethyl starch sodium of 10～100 milliliters/intrinsic viscosity of gram, 0.2～1.0 substitution value, 0～5% (weight) glucose, 0～0.9% (weight) sodium chloride, 0.1～1% (weight) decolouring activated carbon, all the other are deionized water, after the mixing, be heated to the filtration of boiling, again through high temperature or microporous filter sterilization.
2, a kind of contain carboxymethyl starch sodium be used for the treatment of recurrent respiratory tract infection and allergic asthma oral liquid compounding method, it is characterized in that weight with 5～70%() have an intrinsic viscosity, 0.2～1.0 substitution carboxymethyl Starch Sodium of 10～100 milliliters/gram, 0～50%(weight) sugar, 0.01～0.5%(weight) antiseptic, proper amount of edible spice, pigment, all the other are water, mix homogeneously is heated to the sterilization of boiling.
3, a kind of compound method that is used for the treatment of recurrent respiratory tract infection and allergic asthma powder that contains carboxymethyl starch sodium, it is characterized in that weight with 5～70%() have an intrinsic viscosity, 0.2～1.0 substitution carboxymethyl Starch Sodium of 10～100 milliliters/gram, 0～50%(weight) sugar, after all the other are the above-mentioned substance mixing of water, carry out spray drying or oven dry pulverizing.
4, preparation as claimed in claim 2 contains the method for carboxymethyl starch sodium medicine, it is characterized in that wherein antiseptic can be a benzoate, sulfur dioxide, and propanoic acid, mountain plough acid is to hydroxy methyl or ethyl ester.
5, contain the method for carboxymethyl starch sodium medicine as claim 2 or 3 described preparations, it is characterized in that described sugar can be glucose, fructose, sucrose, maltose.
6, as claim 1,2 or 3 described methods, production method comprising carboxymethyl starch sodium, starch mineral acid heating hydrolysis, reuse sodium hydroxide and monoxone carboxy methylation and purification, it is characterized in that starch is being contained 0～60%(weight) alcohol, 0.01-1M inorganic aqueous acid heating hydrolysis, starch after the hydrolysis sodium hydroxide and monoxone carboxy methylation, mole ratio is followed successively by 1: 0.3-2: 0.2-1.5, product is separated out with pulpous state, use water dissolution, activated carbon decolorizing, post precipitation drying, pulverizing or spray drying in alcohol.
7, method as claimed in claim 6 is characterized in that in the production method of described carboxymethyl starch sodium, during the starch hydrolysis with containing 0～40%(weight) alcohol, the inorganic aqueous acid of 0.02-0.8M.
8, method as claimed in claim 7 is characterized in that in the production method of described carboxymethyl starch sodium, and during the starch carboxy methylation, starch, sodium hydroxide and chloroacetic mole ratio are 1: 0.4-1.5: 0.3-1.2 after the hydrolysis.
9, method as claimed in claim 6 is characterized in that in the production method of carboxymethyl starch sodium described alcohol is methanol, ethanol, propanol, isopropyl alcohol, butanols or isobutanol, and described mineral acid is phosphoric acid, sulphuric acid, hydrochloric acid or nitric acid.
10, method as claimed in claim 7 is characterized in that in the production method of carboxymethyl starch sodium described alcohol is methanol, ethanol, propanol, isopropyl alcohol, butanols or isobutanol, and described mineral acid is phosphoric acid, sulphuric acid, hydrochloric acid or nitric acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87102184 CN1024498C (en) | 1987-02-02 | 1987-02-02 | Manufacture method of medicine to cure repeated intection of respiratory tract and asthma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87102184 CN1024498C (en) | 1987-02-02 | 1987-02-02 | Manufacture method of medicine to cure repeated intection of respiratory tract and asthma |
Related Parent Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 85103760 Division CN85103760B (en) | 1985-05-13 | 1985-05-13 | Preparation of sodium caboxymethyl starch |
| CN85103760 Division | 1987-02-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1036697A CN1036697A (en) | 1989-11-01 |
| CN1024498C true CN1024498C (en) | 1994-05-18 |
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ID=4813847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 87102184 Expired - Lifetime CN1024498C (en) | 1987-02-02 | 1987-02-02 | Manufacture method of medicine to cure repeated intection of respiratory tract and asthma |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1024498C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100336829C (en) * | 2003-02-26 | 2007-09-12 | 戴连宝 | Carboxymethyl starch sodium preparation, preparing process and use thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101536978B (en) * | 2009-05-08 | 2011-09-14 | 西安力邦制药有限公司 | Carboxymethyl starch sodium oral solution and preparation method thereof |
-
1987
- 1987-02-02 CN CN 87102184 patent/CN1024498C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100336829C (en) * | 2003-02-26 | 2007-09-12 | 戴连宝 | Carboxymethyl starch sodium preparation, preparing process and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1036697A (en) | 1989-11-01 |
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