CN101822818B - Composition of Chinese yam polysaccharide and Chinese yam protein and application thereof - Google Patents
Composition of Chinese yam polysaccharide and Chinese yam protein and application thereof Download PDFInfo
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- CN101822818B CN101822818B CN2010101715361A CN201010171536A CN101822818B CN 101822818 B CN101822818 B CN 101822818B CN 2010101715361 A CN2010101715361 A CN 2010101715361A CN 201010171536 A CN201010171536 A CN 201010171536A CN 101822818 B CN101822818 B CN 101822818B
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Abstract
The invention relates to a composition of Chinese yam polysaccharide and Chinese yam protein and an application thereof. The composition of the Chinese yam polysaccharide and Chinese yam protein comprises natural active substances extracted from Dioscoreaceae Chinese yam and other Dioscoreaceae plants and is yellowish-brown powder. The clinical observation proves that the natural composition of the Chinese yam polysaccharide and Chinese yam protein has good medical application of treating sleep apnea syndrome, and obvious effect.
Description
Technical field
The present invention relates to the composition and use thereof of a kind of Chinese yam polysaccharide and potato white matter, relate in particular to Chinese yam polysaccharide and the potato white matter compositions purposes in the medicine of preparation treatment sleep apnea syndrome class.
Background technology
The compositions of Chinese yam polysaccharide and potato white matter is to be present in Dioscoreaceae yam Rhizoma Dioscoreae; And the natural activity composition in other platymiscium of Dioscoreaceae; Chinese yam polysaccharide has blood sugar lowering, improves immunity; And the good action (Zheng Huzhan edits " Chinese medicine modern study and application " first volume, Xueyuan Press, 568-570 page or leaf) of slow down aging.At natural drug research and production field, all be Chinese yam polysaccharide to be separated the back use separately with the potato white matter usually.
Sleep apnea syndrome is a kind of relatively more multiple disease, and pilosity is born in obese people, but in the normal crowd of part body weight, generation is arranged also, and in some specific professional population, in truckie, sickness rate is more concentrated.
The general symptom of all snoring with severe simultaneously of sleep apnea syndrome patient; But after the regular period, then be certain to occur; Therefore; Medical circle generally believes that the severe snoring is the symptom in early stage of sleep apnea syndrome, so severe snoring and sleep apnea briefly are called sleep apnea syndrome.
Sleep apnea syndrome patient's sleep quality extreme difference; Patient's work and life have greatly been influenced; Even more serious sleep apnea syndrome patient major part all can concurrent hypertension, tend to cause apoplexy, new machine infraction, even cause soldier's serious consequence of waiting indefinitely.
Sleep apnea syndrome is a kind of independent disease that can cause serious consequence, but does not still have a kind of medicine of treating sleep apnea syndrome ad hoc, effectively clinically at present, for this treatment of diseases; Mainly be perhaps to use per nasal positive airway pressure respirator treatment with surgical operation at present, but the surgical operation cure rate is low, relapse rate is high; Though the respirator effective percentage is very high, because of uncomfortable, inconvenience; And must use throughout one's life, therefore do not accepted by a lot of patients.
The natural composition of Chinese yam polysaccharide provided by the invention and potato white matter is proving through clinical observation, and said composition can be treated sleep apnea syndrome effectively, and effect is remarkable.
Summary of the invention
The object of the invention is, a kind of Chinese yam polysaccharide and potato white matter composition and use thereof are provided, and the compositions of described Chinese yam polysaccharide and potato white matter is a Dioscoreaceae yam Rhizoma Dioscoreae; And the natural active matter that extracts in other platymiscium of Dioscoreaceae; For a kind of yellowish-brown powder, prove the natural composition of Chinese yam polysaccharide and potato white matter through clinical observation; Have the purposes of the medicine of good curing sleep apnea syndrome, effect is remarkable.
The compositions of Chinese yam polysaccharide of the present invention and potato white matter; Said composition is the active substance that extracts by in the Dioscoreaceae yam Rhizoma Dioscoreae; Be a kind of yellowish-brown powder, described Chinese yam polysaccharide and potato white matter preparation of compositions method follow these steps to carry out:
A, Rhizoma Dioscoreae is pulverized, with Rhizoma Dioscoreae weight 2-5 water heating doubly, temperature 50-100 ℃, reflux, extract, 2-3 time, time 2-3 hour, filtration, merge extractive liquid,, filtration is concentrated into 50%;
B, concentrated solution is added 95% ethanol, make concentrated solution contain the alcohol amount and reach 30%, post precipitation occurs precipitate is removed;
C, continue in concentrated solution, to add 95% ethanol and make and contain the alcohol amount and reach 90%; Left standstill 3-6 hour after having precipitate to occur; Make the abundant post precipitation of precipitate, take out supernatant collecting precipitation thing, carry out drying again; Pulverize, can obtain yellowish-brown powder Chinese yam polysaccharide content is that 40-50% and potato white matter are the compositions of content 30-40%.
What Chinese yam polysaccharide was made up of mannose, glucose and galactose is main mannan with the mannose, and its mol ratio is 6.45: 1: 1.26.
The polysaccharide of the glycoprotein in the potato white matter partly is made up of 80% mannose and a spot of galactose, xylose, fructose and glucose; Obtain 16 seed amino acids after the protein portion hydrolysis of glycoprotein; Be lysine, histidine, arginine, aspartic acid, threonine, methionine, serine, glutamic acid, proline, alanine, valine, glycine, isoleucine, leucine, tyrosine, phenylalanine.
The pharmaceutical preparation that the compositions of Chinese yam polysaccharide and potato white matter and pharmaceutically acceptable carrier or complementary composition are prepared into is capsule, granule, tablet, powder, oral liquid, syrup.
Described compositions is in the purposes of the medicine of preparation treatment sleep apnea syndrome.
Chinese yam polysaccharide of the present invention and protein natural composition can directly be processed into medicine with it, also can add the pharmaceutical preparation that pharmaceutically acceptable carrier or complementary composition are prepared from, and described pharmaceutical preparation can be; Capsule, granule, tablet; Powder; Oral liquid, syrup or with other Chinese medicine, the compound preparation that active skull cap components and chemosynthesis components compatibility form.
The natural composition of Chinese yam polysaccharide and potato white matter derives from the Dioscoreaceae plant, and the medicine source is sufficient, and it is simple and easy to do to extract method for preparing, can be made into capsule, tablet, granule, oral liquor and other types of formulations.Sleep apnea syndrome can not only be treated effectively, immunity can also be improved, slow down aging.Have characteristics such as evident in efficacy, safe and convenient to use.
Below through embodiment content of the present invention is remake further detailed description.But should this be interpreted as that above-mentioned theme only limits to following instance.
The specific embodiment
Embodiment 1
A, be raw material, remove vegetable fault the dry rhizome of Rhizoma Dioscoreae crude drug in whole, take by weighing 10 kilograms of pulverizing after, with the water heating of 2 times of Rhizoma Dioscoreae weight, 50 ℃ of temperature, reflux, extract, 2 times, 2 hours time, filter, merge extractive liquid, is with being concentrated into 50% behind the extracting liquid filtering;
B, concentrated solution is added 95% ethanol, make concentrated solution contain the alcohol amount and reach 30%, post precipitation occurs precipitate is removed;
C, continue in concentrated solution, to add 95% ethanol and make and contain the alcohol amount and reach 90%; Left standstill 3 hours after having precipitate to occur; Make the abundant post precipitation of precipitate, take out supernatant collecting precipitation thing, carry out drying again; Pulverize, can obtain yellowish-brown powder Chinese yam polysaccharide content is that 40-50% and potato white matter are the compositions of content 30-40%.
Embodiment 2
A, be raw material, remove vegetable fault the dry rhizome of Rhizoma Dioscoreae crude drug in whole, take by weighing 10 kilograms of pulverizing after, with the water heating of 5 times of Rhizoma Dioscoreae weight, 100 ℃ of temperature, reflux, extract, 3 times, 3 hours time, filter, merge extractive liquid, filters, and is concentrated into 50%;
B, concentrated solution is added 95% ethanol, make concentrated solution contain the alcohol amount and reach 30%, post precipitation occurs precipitate is removed;
C, continue in concentrated solution, to add 95% ethanol and make and contain the alcohol amount and reach 90%; Left standstill 6 hours after having precipitate to occur; Make the abundant post precipitation of precipitate, take out supernatant collecting precipitation thing, carry out drying again; Pulverize, can obtain yellowish-brown powder Chinese yam polysaccharide content is that 40-50% and potato white matter are the compositions of content 30-40%.
Embodiment 3
A, be raw material with the dry rhizome of Rhizoma Dioscoreae crude drug in whole, after removing vegetable fault and taking by weighing 10 kilograms of pulverizing, with the water heating of 3.5 times of Rhizoma Dioscoreae weight, 80 ℃ of temperature, reflux, extract, 3 times, 2.5 hours time, filter, merge extractive liquid, filters, and is concentrated into 50%;
B, concentrated solution is added 95% ethanol, make concentrated solution contain the alcohol amount and reach 30%, post precipitation occurs precipitate is removed;
C, continue in concentrated solution, to add 95% ethanol and make and contain the alcohol amount and reach 90%; Left standstill 4.5 hours after having precipitate to occur; Make the abundant post precipitation of precipitate, take out supernatant collecting precipitation thing, carry out drying again; Pulverize, can obtain yellowish-brown powder Chinese yam polysaccharide content is that 40-50% and potato white matter are the compositions of content 30-40%.
The compositions of Chinese yam polysaccharide of the present invention and potato white matter is in the purposes of the medicine of preparation treatment sleep apnea syndrome; Owing to still do not have a kind of animal model of reliable ability simulating human sleep apnea syndrome at present, therefore can't carry out the zoopery of pharmacodynamics.Owing to belonging to a kind of food that both can be used as, Rhizoma Dioscoreae also can have safety simultaneously as the medicine food dual purpose plant of medicine.Through volunteer's test-meal Chinese yam polysaccharide and the potato white matter natural composition of selecting 10 sleep apnea syndromes at random; Instructions of taking: every day 2 times; Each 2 grams, (2 grams are equivalent to 30 grams of crude drug in whole), and observed the test-meal effect; Wherein: 10 sleep apnea syndrome patient 8 people are the male, and 2 people are the women.Wherein 2 people are mother child relation.Detect and adopt German somnocheck sleep analysis monitor appearance to detect.PSG carries out nasal cavity and pars oralis pharyngis routine physical examination earlier before detecting. and with apnea hyponea index (AHI) is main observation index.20 days test-meal time, the result shows: according to these 10 sleep apnea syndrome volunteers, and the aggregation of data analysis of AHI (asphyxia disturbance index) before and after the test-meal; Except that 2 polypous patients of the severe that occurs together are invalid; Remaining 8 people AHI has the different decline of degree, and the natural composition of Chinese yam polysaccharide and potato white matter is described, is significantly and rapidly to the effect of sleep apnea syndrome; Has safety, the obvious results characteristics.
Claims (3)
1. the compositions of Chinese yam polysaccharide and potato white matter is in the purposes of the medicine of preparation treatment sleep apnea syndrome; It is characterized in that said composition is the active substance that extracts by in the Dioscoreaceae yam Rhizoma Dioscoreae; Be a kind of yellowish-brown powder, described Chinese yam polysaccharide and potato white matter preparation of compositions method follow these steps to carry out:
A, Rhizoma Dioscoreae is pulverized, with Rhizoma Dioscoreae weight 2-5 water heating doubly, temperature 50-100 ℃, reflux, extract, 2-3 time, time 2-3 hour, filtration, merge extractive liquid,, filtration is concentrated into 50%;
B, concentrated solution is added 95% ethanol, make concentrated solution contain the alcohol amount and reach 30%, post precipitation occurs precipitate is removed;
C, continue in concentrated solution, to add 95% ethanol and make and contain the alcohol amount and reach 90%; Left standstill 3-6 hour after having precipitate to occur; Make the abundant post precipitation of precipitate, take out supernatant collecting precipitation thing, carry out drying again; Pulverize, can obtain yellowish-brown powder Chinese yam polysaccharide content is that 40-50% and potato white matter are the compositions of content 30-40%.
2. according to the purposes of the said compositions of claim 1, what it is characterized in that Chinese yam polysaccharide is made up of mannose, glucose and galactose is main mannan with the mannose, and its mol ratio is 6.45: 1: 1.26.
3. according to the purposes of the said compositions of claim 1; The polysaccharide that it is characterized in that the glycoprotein in the potato white matter partly is made up of 80% mannose and a spot of galactose, xylose, fructose and glucose; Obtain 16 seed amino acids after the protein portion hydrolysis of glycoprotein; Be lysine, histidine, arginine, aspartic acid, threonine, methionine, serine, glutamic acid, proline, alanine, valine, glycine, isoleucine, leucine, tyrosine, phenylalanine.
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| CN101822818B true CN101822818B (en) | 2012-06-27 |
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| US9757401B2 (en) * | 2011-11-11 | 2017-09-12 | Nova Neura, Llc | Method for relieving neurogenic pain |
| CN102920991B (en) * | 2012-12-05 | 2014-05-07 | 多力坤·马木特 | Application of composition of Chinese yarn polysaccharide and Chinese yarn protein |
| CN102920998B (en) * | 2012-12-05 | 2013-12-25 | 多力坤·马木特 | Application of Chinese yarn glycoprotein in improvement of activities of oxidative metabolism enzymes of mitochondria of brain cell |
| PH12013000060A1 (en) * | 2013-02-15 | 2016-10-17 | Leano Milagros | Pharmacological indications and uses of preparations from dioscorea hispida |
| CN106923340A (en) * | 2017-03-28 | 2017-07-07 | 许昌学院 | A kind of Chinese yam polysaccharide oral liquid and preparation method thereof |
| CN109081864A (en) * | 2018-07-02 | 2018-12-25 | 西安交通大学 | A kind of method for extraction and purification of Chinese potato glucoprotein |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101214378A (en) * | 2008-01-14 | 2008-07-09 | 中国农业大学 | Yam polysaccharide complex immunity globulin anti-infectious preparations and preparation thereof |
| CN101317622A (en) * | 2008-03-25 | 2008-12-10 | 江苏大学 | Chinese potato glucoprotein product and ultrasonic auxiliary extracting method thereof |
| CN101628070A (en) * | 2009-08-04 | 2010-01-20 | 江苏省中国科学院植物研究所 | Chinese yam polysaccharides extract and preparation method and application thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101214378A (en) * | 2008-01-14 | 2008-07-09 | 中国农业大学 | Yam polysaccharide complex immunity globulin anti-infectious preparations and preparation thereof |
| CN101317622A (en) * | 2008-03-25 | 2008-12-10 | 江苏大学 | Chinese potato glucoprotein product and ultrasonic auxiliary extracting method thereof |
| CN101628070A (en) * | 2009-08-04 | 2010-01-20 | 江苏省中国科学院植物研究所 | Chinese yam polysaccharides extract and preparation method and application thereof |
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Owner name: KASHI AIWEIMATE UYGUR PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: MAMUTE DUOLIKUN Effective date: 20140606 |
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