CN2648447Y - Separator of low pressure liquid phase chromatography - Google Patents
Separator of low pressure liquid phase chromatography Download PDFInfo
- Publication number
- CN2648447Y CN2648447Y CN 200320100295 CN200320100295U CN2648447Y CN 2648447 Y CN2648447 Y CN 2648447Y CN 200320100295 CN200320100295 CN 200320100295 CN 200320100295 U CN200320100295 U CN 200320100295U CN 2648447 Y CN2648447 Y CN 2648447Y
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- reservoir
- chromatographic column
- liquid
- liquid inlet
- low pressure
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Abstract
The utility model provides a low-pressure liquid-phase chromatogram separating device, comprising a liquid flume that is used for containing liquid and at least two chromatogram columns. Each chromatogram column is connected with a bottom canal of the liquid flume. An air or liquid inlet is arranged on the upper part of the liquid flume, and the air or liquid inlet is connected with an air-feeding system or a stuff-feeding system through a valve. The device can realize a half-automatization of the chromatogram separating process, which is good for the big-scale industrial application.
Description
Technical field
The utility model belongs to the analytical chemistry field, is specifically related to the liquid chromatography tripping device.
Background technology
The moving phase of classical liquid chromatography only relies on action of gravity, and by the chromatographic column stationary phase, velocity of separation is slow from top to bottom, and a separation cycle needs several hours to tens hours.In addition, the resin bed of classical chromatographic column should be covered by solution fully, does not allow bubble in the bed and exists, and sneaks into if any bubble, can cause that the post of chromatographic column is imitated great changes, and be difficult to get rid of, and generally need adorn post again, thereby influence the life-span of chromatographic column.
Also have, the reservoir of classical liquid chromatography tripping device has only several milliliters, for the single-column operation, can not realize continuous drip washing and regeneration, can not realize quick separation and concentration, and it is more time-consuming to operate, and is difficult for realizing the large-scale industrialization application.
Summary of the invention
The purpose of this utility model is at the existing defective of classical liquid chromatography tripping device, and a kind of quick, efficient, economic low pressure liquid chromatography tripping device is provided.
Low pressure liquid chromatography tripping device provided by the utility model, the reservoir and the chromatographic column that comprise contain fluid, fill stationary phase in the chromatographic column, its number is at least 2, the bottom of reservoir is provided with at least 2 conduits that have valve, each chromatographic column is connected with the conduit ground, establishes gas or liquid inlet on reservoir top, and described gas or liquid inlet link to each other with air supply system or feeder system by valve.
The number of chromatographic column is decided according to need.
Gas and liquid inlet can be a passage, also can separately be set to two independently passages.
During actual the use, reservoir generally is divided into drip washing reservoir and regeneration reservoir, uses separately.
In addition, the length of chromatographic column is 150mm～300mm, and internal diameter is 2.5mm～6mm, and working pressure is 0.1MPa～0.5MPa.
When using this equipment, two kinds of operations of application of sample drip washing and column regeneration are arranged.During application of sample drip washing, operation as follows: close all valves of reservoir bottom conduit, in reservoir, add an amount of eluent.Sample low pressure upper prop links to each other chromatographic column one by one with reservoir bottom conduit, open gas inlet port valve, pressurization, the valve of unlatching reservoir bottom conduit, beginning drip washing.During column regeneration, the chromatographic column that needs are regenerated links to each other with the reservoir that regenerated liquid is housed, and method of operating is the same.
This device is operated under the low-pressure state, and moving phase is accelerated greatly by the speed of chromatographic column stationary phase, and velocity of separation is improved.In addition, by the pressure emptying, can solve air bubble problem in the resin bed effectively.Because the volume of reservoir strengthens, need not repeatedly add leacheate or regenerated liquid, only need just can control the process of separation or column regeneration, realize the semi-automation of chromatographic resolution work easily, be beneficial to large-scale commercial Application according to the solution amount that flows out chromatographic column.Therefore, low pressure liquid chromatography tripping device provided by the utility model is a kind of quick, efficient, economic liquid chromatography tripping device.
Description of drawings
Fig. 1 low-pressure chromatography tripping device structural representation.
The another kind of low-pressure chromatography tripping device of Fig. 2 structural representation.
Embodiment
Below in conjunction with embodiment the technical solution of the utility model is further elaborated.
Embodiment 1
A kind of low pressure liquid chromatography tripping device comprises the reservoir 1 of at least two chromatographic columns 2 and contain fluid, and the bottom of reservoir 1 is provided with at least two conduits 6, is equipped with valve 3 on each conduit 6.Each chromatographic column 2 is connected with conduit 3 grounds.Establish gas or liquid inlet 4 on reservoir 1 top, gas or liquid inlet 4 link to each other with air supply system or feeder system by valve 5.Fill stationary phase 7 in the chromatographic column 2, stationary phase 7 is various anion and cation exchange resin.
The number of chromatographic column is at least two, decides according to need.In the present embodiment, use 4 root chromatogram columns.
The length of chromatographic column 2 is 150mm～300mm, and internal diameter is 2.5mm～6mm, and working pressure is 0.1MPa～0.5MPa, and the volume of reservoir 1 is 100mL～10000mL.In the present embodiment, root chromatogram column length is 250mm, and internal diameter is 4mm, and working pressure is 0.2MPa, and the volume of reservoir 1 is 500mL.
In the present embodiment, reservoir 1 is divided into drip washing reservoir and two of regeneration reservoirs, finishes drip washing and regeneration task respectively.
Embodiment 2
The low pressure liquid chromatography tripping device that present embodiment provided, structure is similar with embodiment 1, difference is to establish gas inlet port 10 and liquid inlet 8 respectively on reservoir 1 top, gas inlet port 10 links to each other with air supply system by valve 11, and liquid inlet 8 links to each other with feeder system by valve 9.
Claims (3)
1. low pressure liquid chromatography tripping device, the reservoir and the chromatographic column that comprise contain fluid, fill stationary phase in the chromatographic column, it is characterized in that: the number of chromatographic column (2) is at least 2, the bottom of reservoir (1) is provided with at least 2 conduits (6) that have valve (3), each chromatographic column (2) is connected with conduit (6) ground, establishes gas or liquid inlet (4) on reservoir (1) top, and described gas or liquid inlet (4) link to each other with air supply system or feeder system by valve (5).
2. chromatographic separation device according to claim 1 is characterized in that: the gas on reservoir (1) top or liquid inlet (4) branch are arranged, and are respectively gas inlet port (10) and liquid inlet (8).
3. chromatographic separation device according to claim 1 is characterized in that: the length of chromatographic column (2) is 150mm～300mm, and internal diameter is 2.5mm～6mm, and working pressure is 0.1MPa～0.5MPa, and the volume of reservoir (1) is 100mL～10000mL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200320100295 CN2648447Y (en) | 2003-10-15 | 2003-10-15 | Separator of low pressure liquid phase chromatography |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200320100295 CN2648447Y (en) | 2003-10-15 | 2003-10-15 | Separator of low pressure liquid phase chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2648447Y true CN2648447Y (en) | 2004-10-13 |
Family
ID=34339177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200320100295 Expired - Fee Related CN2648447Y (en) | 2003-10-15 | 2003-10-15 | Separator of low pressure liquid phase chromatography |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2648447Y (en) |
-
2003
- 2003-10-15 CN CN 200320100295 patent/CN2648447Y/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20041013 Termination date: 20111015 |