CN2642235Y - Device for diagnosing and curing malignant tumor - Google Patents
Device for diagnosing and curing malignant tumor Download PDFInfo
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- CN2642235Y CN2642235Y CN 03264541 CN03264541U CN2642235Y CN 2642235 Y CN2642235 Y CN 2642235Y CN 03264541 CN03264541 CN 03264541 CN 03264541 U CN03264541 U CN 03264541U CN 2642235 Y CN2642235 Y CN 2642235Y
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Abstract
The utility model relates to a device for diagnosing and curing the malignant tumor, including a light generating device with an adjustable radiation degree and an output of the UV light, a light transmission device, a detection device for the outer radiation degree and a fluorescence detection device; the UV light sent from the light generating device is respectively transmitted to the detection end of the input light guide fiber arranged in the target tissue and the detector in the fluorescence detection device to detect the UV irradiation degree generated by the light generating device through the input light guide fiber and the input light detection and light guide fiber connected with the light generating device; the input end of the fluorescence-collecting light guide fiber and the coaxial mixed row on the probing end of the input light guide fiber near the target tissue is the composite fiber; the characteristics produced by the target tissue is transmitted to the photomultiplier tube through the output end of the fluorescence-collecting light guide fiber; the photomultiplier tube is arranged in the fluorescence detection device to detect the brightness of the fluorescence; the fluorescence signal transmitted by the photomultiplier tube displays the fluorescence brightness on the fluorescence brightness display window in the digital form after being processed by the electronic circuit.
Description
Invention field
This utility model relates to a kind of diagnosis or treatment malignant tumor, the particularly device of early stage malignant tumor.
Background technology
From the seventies, proved the existence characteristic fluorescence different in the malignant tumor tissue with the autofluorescence of normal structure, scientist attempts to observe and the characteristic fluorescence of record tumor tissues by fluorescence spectrophotometer, differentiates, diagnosing malignant tumor.
People such as the Cai Chengxi of University of tsukuba think, under excite of argon ion laser of 5145A as excitation source, normal specimen with contain the tumor cell specimen and produce different characteristic fluorescences, therefore the spectrum difference of two kinds of fluorescence can determine whether to exist malignant tumor by analyzing spectrum; The obvious defects of this scheme is that the fluorescence bluish-green visible and that be excited that argon ion laser produces superposes in the visible light section.
CN85100242 is disclosed also to be a kind of spectroscopic analysis methods, this scheme wishes to overcome because cause the low defective of sensitivity a little less than the excitation source energy, its disclosed method has been improved light source and transmission system, light source adopts the black light of 3000-4000A, both avoided the stack of fluorescence excitation spectrum, can improve the energy of excitation source again greatly, farthest excite the autofluorescence of tumor tissues, be convenient to perusal and spectroscopic diagnostics.
CN97106273 thinks that spectra methods is too complicated, proposes a kind of method of coming cancer diagnosis by the ratio of fluorescent value between normal and the abnormal structure.
But as the disclosed method that relies on perusal or spectrum analysis of CN85100242 and device when the diagnosing malignant tumor, the mistaken diagnosis that the possibility that detects by an unaided eye causes owing to color distortion, the used device of spectrum analysis exists the cost height, to the demanding defective of operator's professional skill, limit its use, particularly in this device for the having relatively high expectations of the colour splitting system in the optical processing system, Circuits System and scanning system, make distorted signals (referring to ZL87105948 background technology part) easily.Disclosed method and device among the CN97106273, its testing process and result are subjected to the interference of the autofluorescence of tumor autofluorescence and normal structure on the one hand, on the other hand since the development of abnormal structure from the initial stage to the later stage, diversity is low between its fluorescent value and the normal value, so accuracy is not high.This just causes coming diagnosing tumour by measuring the primary fluorescence exceptional value measured in primary fluorescence normal value and the unusual position of same measured self and their rate value, the normal position that is set is disturbed, cause serious deviation even influence to detect and diagnostic result.
EP1610616, JP59-40869 propose to utilize photoactive substance blood quinoline derivant (HPD) in the intermediary accumulation of tumor cell, adopt fluorescent lamp, the irradiation of pumping dye laser to obtain the fluorescence that HPD is excited, and judge whether to exist tumor with this.
CN87103403 thinks that the defective of said method is that power is little, can not shine deep layer; This scheme proposes a kind of new medical impulse laser unit, and point out to diagnose with 405nm wavelength, treatment LASER Light Source with the 630nm wavelength, this scheme is used photosensitizer HPD equally, and point out once more, 405nm can effectively excite the distinctive fluorescence of HPD, and the mean power and the peak value of this tissue output are moderate.
In fact, the anaphylaxis of HPD is very strong, injects HPD and can not see light in a couple of days thereafter, and this is to make us unacceptable in general inspection and tumor examination.
CN94106907 thinks that the gas laser of prior art is difficult to consistent wavelength and simple wavelength regulation; Therefore proposed to select for use HPD/PH1126/NPE6 as photosensitizer, adopted the controlled laser machine of wavelength to produce exciting light, by picture analyzing and diagnosing tumor.
That but the defective of above-mentioned exciting light source and checkout gear is an equipment is huge, cost is high, the instructions for use height.
Summary of the invention
The purpose of this utility model is to provide a kind of device of diagnosing or treating early stage malignant tumor, this device can produce the exciting light that excites this utility model Bombyx mori L. extract to produce characteristic fluorescence and the detection system of reception, detection and this characteristic fluorescence of processing, can be efficiently, the early stage canceration (precancerous lesion) organized of high-accuracy ground resolution; The irradiance of this device excitation source is adjustable in addition, makes testing result repeatability height, and this apparatus structure is simple in addition, production cost is low, and operation and diagnosis are easily.
Device described in the utility model comprises: light generating apparatus, light transmitting device, uv radiation intensity checkout gear and fluorescence detection device that irradiance is adjustable, the output ultraviolet light, light transmitting device comprise that input optical fiber, fluorescence are gathered optical fibers and input light detects optical fibers; The input optical fiber of the ultraviolet light that light generating apparatus sends through being attached thereto and input light detect optical fibers and are sent to the photodetector that the detection end of the input optical fiber that is arranged in target tissue and fluorescence detection device are used to detect the uv radiation intensity that light generating apparatus sends respectively, it is composite fibre with the coaxial mixing of end of probe part near the input optical fiber of target tissue that fluorescence is gathered fibre-optic input, and the characteristic fluorescence that the photosensitizer of target tissue is produced is gathered fibre-optic outfan through fluorescence and is sent to photomultiplier tube in the fluorescence detection device, the fluorescence signal of photomultiplier tube output is presented at fluorescent brightness on the fluorescent brightness display window with digital form after electronic circuit is handled, or the fluorescence signal of photomultiplier tube output outputs to after electronic circuit is handled and is used to write down or the monitor or the computer of date processing.
The ultraviolet light that the photodetector of uv radiation intensity receives is presented at uv radiation intensity on the ultraviolet display in the detector with digital form after circuit conversion, or output to be used to write down or the monitor or computer of date processing in.
The wave-length coverage that photodetector is surveyed ultraviolet light is 320-400nm.
In light generating apparatus, or light generating apparatus is connected part or input optical fiber with input optical fiber input end is provided with one first filtering apparatus.After the optical filter colour filter, what be sent to the input optical fiber input is the narrow band uv radiation of 365 ± 15nm, preferably imports the narrow band uv radiation of 365 ± 10nm.
Described first filtering apparatus is two optical filters.
Between fluorescence is gathered photomultiplier tube in fibre-optic outfan and the fluorescence detection device, one second filtering apparatus is set.The optical filter that second filtering apparatus passes through for the red fluorescence that only allows the 600--750nm wavelength, its purpose is that filtering ultraviolet radiant light, autofluorescence and various veiling glares such as other scatterings or stack to the interference of accuracy of detection, avoid ultraviolet radiant light, autofluorescence interference detection results.Preferred detecting unit detects the fluorescent brightness at wavelength 610--700nm place, and preferred wavelength is 650 ± 15nm.
Diagnosis of the present utility model or treat early stage malignant tumor device in fluorescence detection device in the response range of photomultiplier tube be 300-850nm, anode sensitivity 100-300A/lm.
Light generating apparatus output irradiance greater than 0 to less than 1.999mW/cm
2The adjustable black light of irradiance.If first filtering apparatus is arranged within the light generating apparatus, then the light generating apparatus output wavelength is that 365 ± 15nm, irradiance are to 1.999mW/cm greater than 0
2The adjustable black light of irradiance.
Light generating apparatus comprises: high voltage mercury lamp, a paraboloidal mirror, a reflecting mirror and a filtering apparatus that sends light source that sets within it, the radiant light that high voltage mercury lamp sends converges on the reflecting mirror through paraboloidal mirror, through mirror reflects, focus to filtering apparatus, after filtering apparatus filters, to the input of input optical fiber.Wherein high voltage mercury lamp, paraboloidal mirror and reflecting mirror are arranged in the cabinet, and filtering apparatus is arranged in the cabinet, the input of input optical fiber or a certain position in the input optical fiber.
For the ease of connecting, on the sidewall that the light of cabinet is exported, a quartzy optical wand is set, a termination of quartzy optical wand is received ultraviolet light, and the other end directly links to each other with fibre-optic input or is connected with fibre-optic input by filtering apparatus.Ultraviolet light through mirror reflects focuses to quartzy optical wand like this, enters the input of input optical fiber through first filtering apparatus.Certain first filtering apparatus also can be arranged on the side that quartzy optical wand receives ultraviolet light.
The inner surface of paraboloidal mirror is coated with a light reflection ultraviolet and reflectance coating that the light of other long waves is all passed.
Described light generating apparatus also be provided with increase, the controller of dim light, make light generating apparatus output irradiance greater than 0 less than 1.999mW/cm
2Black light.In an embodiment of the present utility model, controller class is like a controllable power switch, realize the increase and decrease of light in another embodiment of the present utility model, being provided with the increase and decrease of the window control light of scalable size in the front portion of quartzy optical wand by the size of control input current.In preferred implementation of the present utility model, carry out the adjusting of ultraviolet light quantity by the wedge shape light hurdle of controlling on the parabolic reflector beam convergence point.
Light generating apparatus also is provided with the fan of cooling usefulness.
Wherein input optical fiber and input light detection optical fibers have a common light input end mouth.Described optical fibers is silicon fiber, changes glass fibre into but also fluorescence wherein can be gathered optical fiber.
From input optical fiber gather near the detection end of target tissue and fluorescence fibre-optic input end to it on the 0.3--1mm place, input optical fiber and fluorescence are gathered the coaxial mixing setting of optical fibers two bundle fibers, also can decide according to the detected position degree of depth in vivo that detects.
The brightness range of the red fluorescence that described fluorescence detection device detects is 0-1999cd/m
2
After the signal of telecommunication of the fluorescence of photomultiplier tube output is handled through electronic circuit (A/D converter) in the preferred fluorescence detection device, the brightness of fluorescence is presented on the fluorescent brightness display.At this moment, also further comprise a fluorescence signal analog output mouth in the fluorescence detection device, one end of analog output mouth links to each other with the outfan of A/D converter, and the other end is connected with monitor or with computer, is used for by monitor record or computer processing data.
Concrete diagnostic procedure is: in advance photosensitizer is passed through injection, modes such as oral or atomizing are injected in the human body, replace the biopsy device of endoscope and probe in the body or body surface with composite fibre, utilize light generating apparatus to send, certain irradiance through the input optical fiber conduction, the non-laser light source of wavelength 365 ± 15nm shines suspicious position (target tissue), excite the silkworm excrement extract that enters abnormal structure's (target tissue) to produce intensive characteristic fluorescence, fluorescence is gathered optical fibers fluorescence is sent to photomultiplier tube, after electronic circuit (A/D converter) processing, the brightness of fluorescence is presented on the fluorescent brightness display, differentiate canceration whether occurs by identification and brightness measuring to fluorescence, in conjunction with the position and the size of endoscopic observation tumor, realize the diagnosis of early-stage cancer.During detection, can be 0 to 1.999mW/cm
2Scope in adjust the irradiance of ultraviolet light, be presented at the ultraviolet brightness in the whole range, also the irradiance of ultraviolet light can be fixed on a fixed numeric values, can obtain high fidelity factor like this, and be convenient to same patient's tracking.
Device of the present utility model also can use separately.
Research worker of the present utility model is surprised to find that, cooperate suitable photosensitizer, device described in the utility model is in zoopery, find for model of gastric carcinoma mice and healthy mice control experiment, ratio between the in-house fluorescent value of the fluorescent value of its tissue of tumor group and normal group is more than 8 times, further the contrast experiment finds, the various photosensitizer in the existing skill for the ratio between model of gastric carcinoma mice and its fluorescent value of healthy mice less than 3 times.This species diversity highlights the high sensitivity of this utility model device and photosensitizer.Follow the tracks of in one month and detect three also discoveries, adopt silkworm excrement extract of the present utility model and device thereof when detecting canceration, also to have the effect that improves pathological tissues, particularly for early stage tissue variation, effect is especially obvious, illustrates that silkworm excrement extract of the present utility model also has the therapeutic effect on the photodynamics simultaneously.Use in addition silkworm excrement extract of the present utility model need not lucifuge etc. other conditions, easy to use, have no side effect, the patient is acceptant.
One of this utility model apparatus features is, suitable position at the optical fiber that transmits black light, one black light irradiation checkout gear is set, this checkout gear is actual to have obtained the irradiance of black light in the optical fiber, after circuit conversion, the irradiance of ultraviolet light is presented on the ultraviolet display in the detector with digital form.Different parts or Different Organs to same tissue can accurately be regulated ultraviolet light irradiation intensity, and in the detection of same or Different Individual, all the time the irradiance of ultraviolet light is fixed on the specific numerical value, testing result has repeatability like this, and helps the follow-up investigations of therapeutic effect and pathological development.Two of characteristics are not color with light spectrum analysis method diagnosing malignant tumor.
The advantage of this checkout gear is, in progressively increasing ultraviolet light irradiation intensity process, and can the also corresponding increase of quick dose of fluorescent value that is excited of Direct-detection Optical; Can accurately regulate the ultraviolet light irradiation degree to different positions or organ in addition, guarantee that in the useful life of same light source, the ultraviolet light irradiation degree can remain unanimity by adjustment.
And this has overcome the defective of prior art well, that is, the excessive background values that causes of the irradiance of exciting light is excessive can't detect and the irradiance of exciting light too small cause the too low detection of fluorescent brightness less than.Both of these case all directly influences the accuracy of testing result.Device of the present utility model has in addition overcome also that the irradiance of exciting light in the prior art can not be adjusted and the increase along with service time that causes, uv radiation intensity reduces, and other conditions are constant in the device, and testing result does not have repeatability or occurs the shortcoming of omission easily.
Further, in checkout gear, be provided with an alarm device in this utility model, preset detection model in the alarm device.When fluorescent brightness surpassed the diagnostic cast ormal weight, alarm device was reported to the police by the buzzer of its connection, can be diagnosed as canceration, adopts this mode, can simplify testing process, further reduced the requirement for detecting operation personnel professional skill.
Though have autofluorescence in the organism, up to now, the report of the autofluorescence of normal structure above 600nm do not arranged as yet.This utility model is gathered at fluorescence second optical filter that only allows the red fluorescence of 600--750nm wavelength to pass through is set between the outfan of optical fiber and the photomultiplier tube in the checkout gear, filtering ultraviolet radiant light, autofluorescence, got rid of the influence of various factors, can determine that therefore detected fluorescence all is the fluorescence that photosensitizer sends in the target tissue for testing result.This utility model device is 0.01cd/m for the resolution of fluorescent brightness
2, again because affine, the absorption of the strong selectivity at variation tissue of this utility model photosensitizer, the homergy in the normal structure, even therefore for early stage cytometaplasia, the accuracy rate of detection can reach 98%.
Wherein said photosensitizer preferably adopts the silkworm excrement catabolite.Consumption is a 0.1-100 μ g/kg body weight, and unabsorbed silkworm excrement extract is natural after 12 hours discharges in body.Canceration position retention 12-24 hour.
Device of the present utility model cooperates endoscope to carry out the naked eyes resolution, because its fluorescent value is higher, therefore is more prone to differentiate and the location than prior art.
This utility model is applicable to the early diagnosis of various cancers, especially the detection and the early stage diagnosis that have had the interior canceration of each organ of endoscope's detection, as suspicious pulmonary carcinoma, gastric cancer, bladder cancer, uterus carcinoma, carcinoma of prostate, rectal cancer, the detection at positions such as skin carcinoma and the diagnosis of precancerous lesion.When particularly adopting silkworm excrement extract of the present utility model,,, can greatly hang down the diagnosis that improves early stage cancerous issue even early stage slight tissue variation can both produce retention because it is highly sensitive as photosensitizer.
Device of the present utility model has overcome the available technology adopting LASER Light Source and spectral analysis apparatus is huge, cost an arm and a leg, awkward defective, and ultraviolet source detects inaccurate, the demanding defective of operant level, the diagnosis that provides or to treat the device volume of early stage malignant tumor little, low price, simple to operate, by the absolute value diagnosing malignant tumor and the early stage canceration of characteristic fluorescence, high by zoopery proof accuracy rate.
The specific embodiment
Describe this utility model in detail below in conjunction with the drawings and specific embodiments, described embodiment is used to describe this utility model, rather than restriction this utility model.
Description of drawings
Fig. 1 is the schematic diagram of this utility model diagnosis or treatment tumor device
Fig. 2 is the structure chart of this utility model diagnosis or treatment tumor device
Fig. 3 is the structure chart of another embodiment of this utility model diagnosis or treatment tumor device
Referring to Fig. 1,2. Among Fig. 1, input optical fiber and input light detect optical fiber be collectively referred to as excitation fiber, The fluorescent collecting optical fiber is just collected optical fiber, and opto-electronic conversion equipment therefor wherein is photomultiplier. This reality With novel diagnosis or the treatment malignant tumour device comprise: export adjustable irradiation level ultraviolet light light generating apparatus 1, Light transmitting device 2 and checkout gear 3 comprise uv radiation intensity checkout gear and fluoroscopic examination dress in the checkout gear 3 Put. Light transmitting device comprises that input optical fiber 4, fluorescent collecting optical fiber 5 and input light detect optical fiber 6; Input optical fiber 4 and input light detect optical fiber 6 and have a common light input end section 21. Light is sent out The input optical fiber 4 of the ultraviolet light that generating apparatus 1 sends through being attached thereto and the end of input light detection optical fiber 6 Detection end 8 and checkout gear 3 that section is sent to respectively the input optical fiber that is arranged in target tissue 7 are used for inspection In the photodetector 9 in the uv radiation intensity checkout gear of the ultraviolet light irradiation degree that photometry generating means 1 sends, The input 10 of fluorescent collecting optical fiber 5 with near 8 ones of the detection ends of the input optical fiber of target tissue 7 Dividing coaxial mixing is composite fibre 11, is used in the output 12 of fluorescent collecting optical fiber 5 and the checkout gear 3 Photomultiplier 13 in the fluorescence detection device of fluorescence intensity is connected, and it is glimmering that photomultiplier 13 is exported Optical signal is presented on the fluorescent brightness display window 15 after electronic circuit 14 is processed.
Referring to Fig. 3, in another embodiment of the present utility model, checkout gear 3 comprises two independent settings Uv radiation intensity checkout gear 300 and fluorescence detection device 301. And among Fig. 2, the uv radiation intensity checkout gear Be co-located in the checkout gear 3 with fluorescence detection device.
Between fluorescence is gathered photomultiplier tube in fibre-optic outfan and the fluorescence detection device, one second filtering apparatus 45 is set.Second filtering apparatus 45 enters the purity that photomultiplier tube waters down fluorescence signal for the optical filter that the red fluorescence that only allows the 600--750nm wavelength passes through to prevent ultraviolet radiation.
Light generating apparatus comprises high voltage mercury lamp 16, a paraboloidal mirror 17, a reflecting mirror 18, quartzy optical wand 19 and the filtering apparatus 20 that sends light source, the radiant light that high voltage mercury lamp 16 sends is projected to after paraboloidal mirror 17 converges on the reflecting mirror 18 that is the miter angle setting, after reflection to quartzy optical wand 19, after light defecator 20 filtered, wavelength was that the narrow band uv radiation of 365 ± 15nm enters the input optical fiber 4 with common input end mouth and the input of fluoroscopic examination optical fibers 6.The inner surface of paraboloidal mirror 17 is coated with the black light that only reflects the 330-400nm wavelength and with the reflectance coating of other light transmissions.Filtering apparatus 20 comprises two optical filters, and after the optical filter colour filter, what be sent to the input optical fiber input is the narrow band uv radiation of 365 ± 15nm, preferred 365 ± 10nm.
In an embodiment of the present utility model, the high voltage mercury lamp 16 in the light generating apparatus is electrically connected an adjustable control switch (not shown), the irradiance of the size adjustment output black light by the control input current from 0 to 1.999mW/cm
2In another embodiment of the present utility model, be provided with of the increase and decrease of the window of the scalable light-inletting quantity that is similar to photography shutter with control light in the front portion of quartzy optical wand 19, also can one light barrier 30 be set with reference to the front portion at quartzy optical wand 19 shown in Figure 1, that light barrier 30 is is fan-shaped, semicircle or wedge shape light hurdle, rotation by the turn-knob on the panel 31 drives light barrier 30 rotations, with the irradiance of control output ultraviolet light.
As a kind of conversion, can also in the light path between the convergent point of reflecting mirror 18 and its folded light beam, a dark slide be set, by the action of knob control dark slide, partial occlusion light is with the irradiance (not shown) of control output ultraviolet light.
Input optical fiber 4, input light detect optical fibers 6 and fluorescence collection optical fibers 5 is a silicon fiber.The gathering the two the coaxial mixing of 0.5m place on it of fibre-optic input end near the detection end of target tissue and fluorescence and be set to composite fibre 8 of input optical fiber, optical fiber is placed in the flexible pipe, and the diameter of composite fibre 8 parts is 2 ± 0.15nm.The photomultiplier tube 13 preferred response ranges of checkout gear 3 are 300-850nm, dynode 8-15 level, anode sensitivity 100-300A/lm, voltage 1000V, the photomultiplier tube of dark current 1-10nA, in preferred implementation of the present utility model, photomultiplier tube is that the model that the Beijing Nuclear Instrument Factory produces is the photomultiplier tube of GBB24, and the brightness range of the red fluorescence that photomultiplier tube 13 detects is 0-1999cd/m
2After the signal of telecommunication of the fluorescence of photomultiplier tube 13 outputs is handled through electronic circuit 14 (A/D converter) in the checkout gear 3, fluorescent brightness is presented on the fluorescent brightness display 15.Wherein the resolution of fluorescent brightness is 0.01cd/m
2The accuracy of fluorescent brightness display 15 indications is ± 10%.
In another kind of embodiment of the present utility model, it is glass fibre that fluorescence is gathered optical fibers 5.
The photodetector 9 of ultraviolet ray intensity detects optical fibers 6 by input light and receives the ultraviolet light that light generating apparatus 1 sends, through circuit conversion (A/D converter 46), the irradiance of this ultraviolet light is presented on the ultraviolet display 22 in the checkout gear 3 with digital form.Probe into uv radiation intensity that the ramose biography light beam of human body goes out to hold the 1cm place from 0 to 1.999mW/cm
2Can regulate on demand.The accuracy of ultraviolet display 22 indications is ± 10%.Further also be provided with UV signal analog output mouth in the checkout gear 3 medium ultraviolet irradiance checkout gears, be used for by monitor record or computer processing data.
Photodetector 9 is a silicon photocell, and the light that enters silicon photocell filters through two optical filters of ZWB, QB21.In preferred implementation of the present utility model, photodetector 9 is the UV-A photodetector for the model that photoelectric instrument factory of Beijing Normal University produces.
In another embodiment of the present utility model, checkout gear 3 comprises a fluorescence signal analog output mouth 40, one end of analog output mouth links to each other with the outfan of A/D converter 14, the other end (not shown) that is connected with monitor or computer is used for by monitor record or computer processing data.Also can analog output mouth 40 and fluorescent brightness display 15 be provided with simultaneously.
In checkout gear, be provided with the adjustable alarm device of a threshold values 41 in this utility model, preset detection model in the circuit 43 of alarm device.When fluorescent brightness surpassed the diagnostic cast ormal weight, alarm device was reported to the police by the buzzer 42 of its connection, can be diagnosed as canceration, adopts this mode, can simplify testing process, further reduces the requirement for detecting operation personnel professional skill.
In another embodiment of the present utility model, fluorescent brightness detects and is divided into three ranges, by the knob controlled selection range on the panel of checkout gear.
Ultraviolet light irradiation degree checkout gear of the present utility model adopts the calibration of ultraviolet standard irradiation instrument, and fluorescent brightness checkout gear scaling light source adds the thick CB550 optical filter of 1.5mm for the A light source.
As for the fixed form of each structure in the light source, can be with reference to the content among the ZL97106273.0 ZL85100424Z100216974.6.
Show through zoopery and clinical experiment, photosensitizer of the present utility model and checkout gear, the accuracy rate that detects for malignant tumor can reach 92-98%, can reach 89-93% for the recall rate of precancerous lesion.This apparatus structure is simple, processing ease, and cost is low, is a kind of promising medical diagnosis, therapeutic instrument.
Claims (25)
- One kind the diagnosis or the treatment tumor device, comprise: light generating apparatus, light transmitting device, uv radiation intensity checkout gear and fluorescence detection device that irradiance is adjustable, the output ultraviolet light, light transmitting device comprise that input optical fiber, fluorescence are gathered optical fibers and input light detects optical fibers; The input optical fiber of the ultraviolet light that light generating apparatus sends through being attached thereto and input light detect optical fibers and are sent to the photodetector that the detection end of the input optical fiber that is arranged in target tissue and fluorescence detection device are used to detect the uv radiation intensity that light generating apparatus sends respectively, it is composite fibre with the coaxial mixing of end of probe part near the input optical fiber of target tissue that fluorescence is gathered fibre-optic input, and the characteristic fluorescence that the photosensitizer of target tissue is produced is gathered fibre-optic outfan through fluorescence and is sent to photomultiplier tube in the fluorescence detection device, the fluorescence signal of photomultiplier tube output is presented at fluorescent brightness on the fluorescent brightness display window with digital form after electronic circuit is handled, or the fluorescence signal of photomultiplier tube output outputs to after electronic circuit is handled and is used to write down or the monitor or the computer of date processing.
- 2. device according to claim 1, it is characterized in that: wherein the ultraviolet light of the photodetector of uv radiation intensity reception is after circuit conversion, uv radiation intensity is presented on the ultraviolet display in the detector with digital form, or output to be used to write down or the monitor or computer of date processing in.
- 3. device according to claim 1 is characterized in that: wherein in light generating apparatus, or light generating apparatus is connected part or input optical fiber with input optical fiber input end is provided with one first filtering apparatus.After the optical filter colour filter, what be sent to the input optical fiber input is the narrow band uv radiation of 365 ± 15nm, preferably imports the narrow band uv radiation of 365 ± 10nm.
- 4. device according to claim 1 and 2 is characterized in that: second filtering apparatus that only allows the red fluorescence of 600--750nm wavelength to pass through wherein is set between fluorescence is gathered photomultiplier tube in fibre-optic outfan and the fluorescence detection device.
- 5. according to one of them described device of claim 1-3, it is characterized in that: diagnosis wherein of the present utility model or treat early stage malignant tumor device in fluorescence detection device in the response range of photomultiplier tube be 300-850nm, anode sensitivity 100-300A/lm.
- 6. device according to claim 4 is characterized in that: diagnosis wherein of the present utility model or treat early stage malignant tumor device in fluorescence detection device in the response range of photomultiplier tube be 300-850nm, anode sensitivity 100-300A/lm.
- 7. according to one of them described device of claim 1-3, it is characterized in that: wherein light generating apparatus output irradiance greater than 0 to less than 1.999mW/cm 2The adjustable black light of irradiance.
- 8. device according to claim 4 is characterized in that: wherein light generating apparatus output irradiance greater than 0 to less than 1.999mW/cm 2The adjustable black light of irradiance.
- 9. device according to claim 5 is characterized in that: wherein light generating apparatus output irradiance greater than 0 to less than 1.999mW/cm 2The adjustable black light of irradiance.
- 10. device according to claim 6 is characterized in that: wherein light generating apparatus output irradiance greater than 0 to less than 1.999mW/cm 2The adjustable black light of irradiance.
- 11. according to one of them described device of claim 1-3, it is characterized in that: wherein light generating apparatus comprises: high voltage mercury lamp, a paraboloidal mirror, a reflecting mirror and a filtering apparatus that sends light source that sets within it, the radiant light that high voltage mercury lamp sends converges on the reflecting mirror through paraboloidal mirror, through mirror reflects, focus to filtering apparatus, after filtering apparatus filters, to the input of input optical fiber.Wherein high voltage mercury lamp, paraboloidal mirror and reflecting mirror are arranged in the cabinet, and filtering apparatus is arranged in the cabinet, the input of input optical fiber or a certain position in the input optical fiber.
- 12. device according to claim 4, it is characterized in that: wherein light generating apparatus comprises: high voltage mercury lamp, a paraboloidal mirror, a reflecting mirror and a filtering apparatus that sends light source that sets within it, the radiant light that high voltage mercury lamp sends converges on the reflecting mirror through paraboloidal mirror, through mirror reflects, focus to filtering apparatus, after filtering apparatus filters, to the input of input optical fiber.Wherein high voltage mercury lamp, paraboloidal mirror and reflecting mirror are arranged in the cabinet, and filtering apparatus is arranged in the cabinet, the input of input optical fiber or a certain position in the input optical fiber.
- 13. device according to claim 5, it is characterized in that: wherein light generating apparatus comprises: high voltage mercury lamp, a paraboloidal mirror, a reflecting mirror and a filtering apparatus that sends light source that sets within it, the radiant light that high voltage mercury lamp sends converges on the reflecting mirror through paraboloidal mirror, through mirror reflects, focus to filtering apparatus, after filtering apparatus filters, to the input of input optical fiber.Wherein high voltage mercury lamp, paraboloidal mirror and reflecting mirror are arranged in the cabinet, and filtering apparatus is arranged in the cabinet, the input of input optical fiber or a certain position in the input optical fiber.
- 14. device according to claim 7, it is characterized in that: wherein light generating apparatus comprises: high voltage mercury lamp, a paraboloidal mirror, a reflecting mirror and a filtering apparatus that sends light source that sets within it, the radiant light that high voltage mercury lamp sends converges on the reflecting mirror through paraboloidal mirror, through mirror reflects, focus to filtering apparatus, after filtering apparatus filters, to the input of input optical fiber.Wherein high voltage mercury lamp, paraboloidal mirror and reflecting mirror are arranged in the cabinet, and filtering apparatus is arranged in the cabinet, the input of input optical fiber or a certain position in the input optical fiber.
- 15. device according to claim 11, it is characterized in that: wherein on the sidewall of the light of light generating apparatus cabinet output a quartzy optical wand is set, one termination of quartzy optical wand is received ultraviolet light, and the other end directly links to each other with fibre-optic input or is connected with fibre-optic input by filtering apparatus.
- 16. device according to claim 12, it is characterized in that: wherein on the sidewall of the light of light generating apparatus cabinet output a quartzy optical wand is set, one termination of quartzy optical wand is received ultraviolet light, and the other end directly links to each other with fibre-optic input or is connected with fibre-optic input by filtering apparatus.
- 17. device according to claim 13, it is characterized in that: wherein on the sidewall of the light of light generating apparatus cabinet output a quartzy optical wand is set, one termination of quartzy optical wand is received ultraviolet light, and the other end directly links to each other with fibre-optic input or is connected with fibre-optic input by filtering apparatus.
- 18. device according to claim 14, it is characterized in that: wherein on the sidewall of the light of light generating apparatus cabinet output a quartzy optical wand is set, one termination of quartzy optical wand is received ultraviolet light, and the other end directly links to each other with fibre-optic input or is connected with fibre-optic input by filtering apparatus.
- 19. device according to claim 15, it is characterized in that: wherein light generating apparatus also be provided with increase, the controller of dim light amount, controller be regulated power supply switch, scalable size window, be arranged on the wedge shape light hurdle of control on the parabolic reflector beam convergence point, perhaps in the light path between the convergent point of reflecting mirror and its folded light beam, the adjusting that one of dark slide is carried out the ultraviolet light quantity is set.
- 20. device according to claim 16, it is characterized in that: wherein light generating apparatus also be provided with increase, the controller of dim light amount, controller be regulated power supply switch, scalable size window, be arranged on the wedge shape light hurdle of control on the parabolic reflector beam convergence point, perhaps in the light path between the convergent point of reflecting mirror and its folded light beam, the adjusting that one of dark slide is carried out the ultraviolet light quantity is set.
- 21. device according to claim 17, it is characterized in that: wherein light generating apparatus also be provided with increase, the controller of dim light amount, controller be regulated power supply switch, scalable size window, be arranged on the wedge shape light hurdle of control on the parabolic reflector beam convergence point, perhaps in the light path between the convergent point of reflecting mirror and its folded light beam, the adjusting that one of dark slide is carried out the ultraviolet light quantity is set.
- 22. device according to claim 18, it is characterized in that: wherein light generating apparatus also be provided with increase, the controller of dim light amount, controller be regulated power supply switch, scalable size window, be arranged on the wedge shape light hurdle of control on the parabolic reflector beam convergence point, perhaps in the light path between the convergent point of reflecting mirror and its folded light beam, the adjusting that one of dark slide is carried out the ultraviolet light quantity is set.
- 23. according to the described device of claim 1-3, wherein also further comprise a fluorescence signal analog output mouth in the fluorescence detection device, one end of analog output mouth links to each other with the outfan of A/D converter, the other end is connected with monitor or with computer, is used for by monitor record or computer processing data.
- 24. device according to claim 4, wherein also further comprise a fluorescence signal analog output mouth in the fluorescence detection device, one end of analog output mouth links to each other with the outfan of A/D converter, the other end is connected with monitor or with computer, is used for by monitor record or computer processing data.
- 25. device according to claim 5, wherein also further comprise a fluorescence signal analog output mouth in the fluorescence detection device, one end of analog output mouth links to each other with the outfan of A/D converter, the other end is connected with monitor or with computer, is used for by monitor record or computer processing data.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03264541 CN2642235Y (en) | 2003-06-18 | 2003-06-18 | Device for diagnosing and curing malignant tumor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03264541 CN2642235Y (en) | 2003-06-18 | 2003-06-18 | Device for diagnosing and curing malignant tumor |
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| Publication Number | Publication Date |
|---|---|
| CN2642235Y true CN2642235Y (en) | 2004-09-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03264541 Expired - Lifetime CN2642235Y (en) | 2003-06-18 | 2003-06-18 | Device for diagnosing and curing malignant tumor |
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| CN (1) | CN2642235Y (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101862200B (en) * | 2010-05-12 | 2012-07-04 | 中国科学院上海应用物理研究所 | Rapid X-ray fluorescence CT method |
| CN104066372A (en) * | 2012-01-27 | 2014-09-24 | 皇家飞利浦有限公司 | An apparatus for optical analysis of an associated tissue |
| CN109939361A (en) * | 2014-11-19 | 2019-06-28 | 夏普株式会社 | Photodynamic therapy device |
| CN113877066A (en) * | 2020-07-01 | 2022-01-04 | 华润微电子控股有限公司 | Device and method for inspecting and killing mucosa layer |
-
2003
- 2003-06-18 CN CN 03264541 patent/CN2642235Y/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101862200B (en) * | 2010-05-12 | 2012-07-04 | 中国科学院上海应用物理研究所 | Rapid X-ray fluorescence CT method |
| CN104066372A (en) * | 2012-01-27 | 2014-09-24 | 皇家飞利浦有限公司 | An apparatus for optical analysis of an associated tissue |
| CN109939361A (en) * | 2014-11-19 | 2019-06-28 | 夏普株式会社 | Photodynamic therapy device |
| CN109939361B (en) * | 2014-11-19 | 2021-04-06 | 夏普株式会社 | Photodynamic therapy device |
| CN113877066A (en) * | 2020-07-01 | 2022-01-04 | 华润微电子控股有限公司 | Device and method for inspecting and killing mucosa layer |
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