CN2611379Y - Appts. for preparing structural micro-array secondary embedded wax block - Google Patents
Appts. for preparing structural micro-array secondary embedded wax block Download PDFInfo
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- CN2611379Y CN2611379Y CN 03218483 CN03218483U CN2611379Y CN 2611379 Y CN2611379 Y CN 2611379Y CN 03218483 CN03218483 CN 03218483 CN 03218483 U CN03218483 U CN 03218483U CN 2611379 Y CN2611379 Y CN 2611379Y
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- inverted
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- fixed
- baffle plate
- metal sheet
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Abstract
A biotissue micro array twice embedding wax block preparation device comprises a bracket and a wax block container disposed on the base seat, an adjusting fixation device arranged on the bracket is provided with a holding drive device, the holding drive device is a bit holding drive device which is provided with the bit. The biotissue micro array twice embedding wax block preparation device resolves the technical problems of low block producing speed, low efficiency and complicated operation in the technical background.
Description
Technical field
The utility model relates to the apparatus that uses in a kind of medical research field micro-array tissue making processes, is specifically related to a kind of micro-array tissue secondary embedding wax block preparing device.
Background technology
High speed development along with modern science, histology and histopathology are as the basis of supporting the development of whole medical science and even life science and contact microcosm and macrocosm, preclinical medicine and clinical medical bridge subject, its research method comes into one's own day by day and develops, and becomes the important means of research life science.Present Histological research's method and technology all are based on basic tissue slice and carry out.Yet widely used tissue slice usually because can only a kind of or tissue samples of embedding in a paraffin mass, cuts out the section that contains a tissue samples, promptly single tissue slice.When carrying out the scientific research of large sample, must make a large amount of paraffin embedded tissues and tissue slice, carry out the identical experiment operation of repeated multiple times, cause a large amount of wastes of experimental period, human and material resources and related experiment material and reagent, consuming time, consumption power, also make in the same research artificial experimental error be difficult to avoid, the experiment comparability reduces.This prior art obviously can not adapt to the needs of study on large sample.In the case, the Kononen J. professor and his colleague of U.S. national academy in 1998 propose this notion of micro-array tissue technology first, first with a large amount of concentrating on the slice, thin piece from different patient's tumor samples, make the micro micro-array tissue, just can detect DNA, RNA or protein targets or antibody target molecule in hundreds and thousands of the samples simultaneously through an in situ hybridization or immunohistochemical experiment like this, can save great amount of manpower and material resources and financial resources, also can avoid numerous and diverse in a large number, multiple experimental implementation.
Present secondary embedding wax block preparing device, the mode of making secondary embedding paraffin mass has two kinds, and the one, hollow pinprick hole is representative with Beecher instrument company, the patent No.: US6103518, US6383801, this patent is at the application number of China: 00 2 806458.Adopt hollow pinprick hole, but the arrangement independent assortment in its hole, shortcoming is: hole of once-forming, and speed of fulfiling hole is slow, success ratio is not high; When the wax stone periphery is pricked the hole, cause the wax stone cracking easily; When pricking the hole, not of uniform size the causing of exerting oneself can cause that the hole deflects, array is irregular; Power thrusts and perforating needle direction are inconsistent a little during punching, can cause promptly that the hole is crooked, the aperture distortion, and the consequence that wax stone is scrapped reduces working efficiency; Manual punching exists all more or less that hole size is irregular, spacing is inconsistent, deep mixed problem such as cause; Complex operation, uninteresting, success ratio is lower.
The 2nd, the perfusion hole forming method of once-forming is as " a kind of embedding device of making organization chip " of No.2 Hospital Affiliated to Xi-an medical Univ.'s application, number of patent application: 00 2 07528.8.The characteristics of once-forming method are once-formings, i.e. the array fixed hole battle array shaped device made from one group of pin, and its main drawback is
1]. can not arbitrary combination, do the microarray of how many kinds of different specimens number, different specimens diameter, the pin that just needs this fixed combination of how many kinds of need be equipped with the hole battle array shaped device of a large amount of fixed combination during actual the use, so be difficult to realize the industrialization of micro-array tissue production in this way;
2]. position, the depth, the paraffin of combination pin solidify, make ups pin to be extracted etc., and imbalance appears in its arbitrary link, promptly can cause the hole deep mixedly cause, a series of problems such as the hole is crooked;
3]. complex operation, with low content of technology, the wax stone yield rate is low;
4]. it is slower that this device is pricked hole method speed in addition.
The utility model content
It is slow that the utility model has solved in the background technology wax stone finished product speed, and efficient is low, the technical problem of complex operation.
Technical solution of the present utility model is:
A kind of micro-array tissue secondary embedding wax block preparing device, comprise the support 2 and the wax stone holder 9 that are arranged on the base 1, described support 2 is provided with regulates stationary installation 3, this adjusting stationary installation 3 is provided with grasping drive unit, its special character is: described grasping drive unit is a drill bit grasping drive unit 5, and this drill bit grasping drive unit 5 is provided with drill bit 4.
Above-mentioned wax stone holder 9 can be fixed on the base 1 by running gear 10.
Above-mentioned wax stone running gear 10 can comprise horizontal mobile device and longitudinal moving device.
Above-mentioned horizontal mobile device can comprise the metal sheet 17 that is fixed on the base 1, this metal sheet 17 is provided with the inverted U frame 16 that is slidingly matched with it, described inverted U frame 16 is connected with baffle plate 14 on being fixed in base 1 by return spring 15, and the carriage release lever 11 of spiral micrometer 12 passes baffle plate 14 and contacts cooperation with the end face of inverted U frame 16; Above-mentioned longitudinal moving device can comprise the metal sheet 18 that is fixed on the inverted U frame 16, this metal sheet 18 is provided with the inverted U frame 19 that is slidingly matched with it, described inverted U frame 19 is connected with baffle plate 21 on being fixed in base 1 by return spring 20, and the carriage release lever 23 of spiral micrometer 22 passes baffle plate 21 and contacts cooperation with inverted U frame 19; Described wax stone holder 9 is fixed on the inverted U frame 19.
Above-mentioned longitudinal moving device can comprise the metal sheet 18 that is fixed on the base 1, this metal sheet 18 is provided with the inverted U frame 19 that is slidingly matched with it, described inverted U frame 19 is connected with baffle plate 21 on being fixed in base 1 by return spring 20, and the carriage release lever 23 of spiral micrometer 22 passes baffle plate 21 and contacts cooperation with inverted U frame 19; Above-mentioned horizontal mobile device can comprise the metal sheet 17 that is fixed on the inverted U frame 19, this metal sheet 17 is provided with the inverted U frame 16 that is slidingly matched with it, described inverted U frame 16 is connected with baffle plate 14 on being fixed in base 1 by return spring 15, and the carriage release lever 11 of spiral micrometer 12 passes baffle plate 14 and contacts cooperation with inverted U frame 16; Described wax stone holder 9 is fixed on the inverted U frame 16.
The utlity model has following advantage:
1] but. arbitrary combination, according to the pin of the microarray of needs combinations different specimens number, different specimens diameter, need not to be equipped with the hole battle array shaped device of a large amount of fixed combination during use, be easy to the industrialization that realizes that micro-array tissue is produced;
2]. position, the depth, the paraffin of combination pin solidifies, makes up pin link balance of movement homogeneous such as extracts, and can guarantee the quality in hole;
3]. when the wax stone periphery was pricked the hole, wax stone can not ftracture; When pricking the hole, wax stone is stressed, and evenly pore-forming is straight, and array is neat; Can guarantee during punching that force direction is consistent with the perforating needle direction, the aperture uniformity; The pitch of holes unanimity, the hole depth unanimity; So wax stone yield rate height;
4] but. a plurality of holes of once-forming, pore-forming is rapid, high efficiency;
5]. manual operation or automaticmachines operation all can; Easy and simple to handle.
Description of drawings
Accompanying drawing is a structural representation of the present utility model.
Embodiment
Referring to accompanying drawing, support 2 of the present utility model and wax stone holder 9 are with on base 1, and base 1, wax stone holder 9 adopt metal or non-metallic material all can.Support 2 is provided with regulates stationary installation 3, can regulate the height of the drill bit 4 that is driven by drill bit grasping drive unit 5 by this adjusting stationary installation 3.Drill bit grasping drive unit 5 can adopt the drill bit grasping drive unit identical with existing electric drill structure.Wax stone holder 9 is fixed on the base 1 by running gear 10.Wax stone running gear 10 comprises horizontal mobile device and longitudinal moving device and moves up and down device.
A kind of structure formation of horizontal mobile device is: it comprises the metal sheet 17 that is fixed on the base 1, this metal sheet 17 is provided with the inverted U frame 16 that is slidingly matched with it, described inverted U frame 16 is connected with baffle plate 14 on being fixed in base 1 by return spring 15, and the carriage release lever 11 of spiral micrometer 12 passes baffle plate 14 and contacts cooperation with the end face of inverted U frame 16; Described longitudinal moving device comprises the metal sheet 18 that is fixed on the inverted U frame 16, this metal sheet 18 is provided with the inverted U frame 19 that is slidingly matched with it, described inverted U frame 19 is connected with baffle plate 21 on being fixed in base 1 by return spring 20, and the carriage release lever 23 of spiral micrometer 22 passes baffle plate 21 and contacts cooperation with inverted U frame 19; Described wax stone holder 9 is fixed on the inverted U frame 19.
The another kind of structure formation of longitudinal moving device is: it comprises the metal sheet 18 that is fixed on the base 1, this metal sheet 18 is provided with the inverted U frame 19 that is slidingly matched with it, described inverted U frame 19 is connected with baffle plate 21 on being fixed in base 1 by return spring 20, and the carriage release lever 23 of spiral micrometer 22 passes baffle plate 21 and contacts cooperation with inverted U frame 19; Described horizontal mobile device comprises the metal sheet 17 that is fixed on the inverted U frame 19, this metal sheet 17 is provided with the inverted U frame 16 that is slidingly matched with it, described inverted U frame 16 is connected with baffle plate 14 on being fixed in base 1 by return spring 15, and the carriage release lever 11 of spiral micrometer 12 passes baffle plate 14 and contacts cooperation with inverted U frame 16; Described wax stone holder 9 is fixed on the inverted U frame 16.
During punching, blank wax stone 7 is fixed in the wax stone holder 9, and wax stone 7 can or be clamped and fastened in the wax stone holder 9 by screw or spring application.Select the position of punching by the wax stone station-keeping system, digital differential knob 8, the 13 may command running gears 10 by spiral micrometer 12,22 move in X, Y direction.By regulating the distance of drill bit 4 and wax stone 7, the degree of depth of regulating punching.The degree of depth in hole is a fixed, only need regulate once for each wax stone.After the position in hole is determined, open the power switch of drill bit grasping drive unit 5, manipulation operations bar 6, it can drive drill bit 4 and move up and down.Get out a hole rapidly, regulate the position of wax stone 7, can continue to bore second hole ...Blank wax stone is made and is finished, and it can be used as the reception body of secondary embedding donor tissue.The utility model manual operation or automaticmachines operation all can.
Claims (5)
1. micro-array tissue secondary embedding wax block preparing device, comprise the support (2) and the wax stone holder (9) that are arranged on the base (1), described support (2) is provided with regulates stationary installation (3), this adjusting stationary installation (3) is provided with grasping drive unit, it is characterized in that: described grasping drive unit is drill bit grasping drive unit (5), and this drill bit grasping drive unit (5) is provided with drill bit (4).
2. micro-array tissue secondary embedding wax block preparing device as claimed in claim 1, it is characterized in that: described wax stone holder (9) is fixed on the base (1) by running gear (10).
3. micro-array tissue secondary embedding wax block preparing device as claimed in claim 1 or 2, it is characterized in that: described wax stone running gear (10) comprises horizontal mobile device and longitudinal moving device.
4. micro-array tissue secondary embedding wax block preparing device as claimed in claim 3, it is characterized in that: described horizontal mobile device comprises the metal sheet (17) that is fixed on the base (1), this metal sheet (17) is provided with the inverted U frame (16) that is slidingly matched with it, described inverted U frame (16) is connected with baffle plate (14) on being fixed in base (1) by return spring (15), and the carriage release lever (11) of spiral micrometer (12) passes baffle plate (14) and contacts cooperation with the end face of inverted U frame (16); Described longitudinal moving device comprises the metal sheet (18) that is fixed on the inverted U frame (16), this metal sheet (18) is provided with the inverted U frame (19) that is slidingly matched with it, described inverted U frame (19) is connected with baffle plate (21) on being fixed in base (1) by return spring (20), and the carriage release lever (23) of spiral micrometer (22) passes baffle plate (21) and contacts cooperation with inverted U frame (19); Described wax stone holder (9) is fixed on the inverted U frame (19).
5. micro-array tissue secondary embedding wax block preparing device as claimed in claim 3, it is characterized in that: described longitudinal moving device comprises the metal sheet (18) that is fixed on the base (1), this metal sheet (18) is provided with the inverted U frame (19) that is slidingly matched with it, described inverted U frame (19) is connected with baffle plate (21) on being fixed in base (1) by return spring (20), and the carriage release lever (23) of spiral micrometer (22) passes baffle plate (21) and contacts cooperation with inverted U frame (19); Described horizontal mobile device comprises the metal sheet (17) that is fixed on the inverted U frame (19), this metal sheet (17) is provided with the inverted U frame (16) that is slidingly matched with it, described inverted U frame (16) is connected with baffle plate (14) on being fixed in base (1) by return spring (15), and the carriage release lever (11) of spiral micrometer (12) passes baffle plate (14) and contacts cooperation with inverted U frame (16); Described wax stone holder (9) is fixed on the inverted U frame (16).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03218483 CN2611379Y (en) | 2003-01-29 | 2003-01-29 | Appts. for preparing structural micro-array secondary embedded wax block |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03218483 CN2611379Y (en) | 2003-01-29 | 2003-01-29 | Appts. for preparing structural micro-array secondary embedded wax block |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2611379Y true CN2611379Y (en) | 2004-04-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03218483 Expired - Lifetime CN2611379Y (en) | 2003-01-29 | 2003-01-29 | Appts. for preparing structural micro-array secondary embedded wax block |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2611379Y (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1300339C (en) * | 2004-11-08 | 2007-02-14 | 西安交通大学 | Biological tissue micro array chip automatic preparation instrument and control method thereof |
| CN103612279A (en) * | 2013-10-30 | 2014-03-05 | 成都市翻鑫家科技有限公司 | Perforating machine with pressing foot |
| CN104048871A (en) * | 2013-03-11 | 2014-09-17 | 李朝林 | Environmental protective automatic continuous paraffin-embedding device |
| CN106353170A (en) * | 2016-09-24 | 2017-01-25 | 孙珠蕾 | Biological tissue paraffin embedding machine for pathology department |
| CN106769174A (en) * | 2016-11-22 | 2017-05-31 | 南京林业大学 | Plant tissue slice acceptor blank wax stone boring instrument |
-
2003
- 2003-01-29 CN CN 03218483 patent/CN2611379Y/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1300339C (en) * | 2004-11-08 | 2007-02-14 | 西安交通大学 | Biological tissue micro array chip automatic preparation instrument and control method thereof |
| CN104048871A (en) * | 2013-03-11 | 2014-09-17 | 李朝林 | Environmental protective automatic continuous paraffin-embedding device |
| CN104048871B (en) * | 2013-03-11 | 2017-02-22 | 李朝林 | Environmental protective automatic continuous paraffin-embedding device |
| CN103612279A (en) * | 2013-10-30 | 2014-03-05 | 成都市翻鑫家科技有限公司 | Perforating machine with pressing foot |
| CN106353170A (en) * | 2016-09-24 | 2017-01-25 | 孙珠蕾 | Biological tissue paraffin embedding machine for pathology department |
| CN106353170B (en) * | 2016-09-24 | 2019-02-22 | 孙珠蕾 | A kind of pathology department's Paraffin Embedding Machine for Biological Tissue |
| CN106769174A (en) * | 2016-11-22 | 2017-05-31 | 南京林业大学 | Plant tissue slice acceptor blank wax stone boring instrument |
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|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20130129 Granted publication date: 20040414 |