CN2578830Y - Micro-array chip configurating device of biological tissue - Google Patents
Micro-array chip configurating device of biological tissue Download PDFInfo
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- CN2578830Y CN2578830Y CN 02255290 CN02255290U CN2578830Y CN 2578830 Y CN2578830 Y CN 2578830Y CN 02255290 CN02255290 CN 02255290 CN 02255290 U CN02255290 U CN 02255290U CN 2578830 Y CN2578830 Y CN 2578830Y
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Abstract
The utility model belongs to the technical field of medical apparatus and instruments, which provides a micro-array chip configurating device of biological tissue, and the lower part of a frame mount is fixedly connected with a bracket. A plurality of pipe columns are arranged in the bracket, each lower end of the pipe column is provided with a bottom support which is connected with the bottom of the bracket in a drawing and pulling mode, and a plurality of column cores matched with the pipe columns are arranged in the frame mount. Each end of the column cores is fixedly connected with a fixing plate, and the other ends of the column cores are respectively inserted into the pipe column. The fixing plate is fixedly connected with a push and draw rod, and the upper end of frame mount extended out of the upper end of the push and draw rod is connected with a handle. A plurality of tissue can be arranged on the utility model at one time, and in this way, the quantity of processed samples is large once, the processed condition is the same, the interference factor is few, and the error is little. When the utility model can be used for comparing and researching, the utility model has the advantages of strong scientificalness, large information quantity and high work efficiency. The utility model can carry out micro-array research to the tissue after embedded by paraffin, and can carry out micro-array research to the fresh tissue.
Description
Affiliated technical field
The utility model belongs to technical field of medical instruments, mainly proposes a kind of biological tissue micro array chip instrument of arranging.
Background technology
At present, the biochip technology in biological tissue's research field is just in the ascendant, and being used for biological tissue's chip technology that medical domain studies is that the micro-array tissue technology was at first invented use in 1998 by people such as U.S. scientist Kotitieti.This technology has a wide range of applications in biomedical research field, and it carries out the arrangement of micro-array tissue with puncture needle and orientator.Such puncture needle is the single tube single needle mostly, can only sample singly when practical application, and arrange in the location one by one, operates cumbersomely, and job schedule is slow, and efficient is low, and the array of figure of discharge is neat inadequately.And can only use the tissue that paraffin embedding handled and do corresponding research, be difficult to utilize flesh tissue to carry out the research of biochip microarray.
Summary of the invention
The purpose of this utility model promptly produces thus, proposes a kind of biological tissue micro array chip instrument of arranging.This instrument of arranging a plurality of tissues of can disposablely arranging both can be done microarray research to the tissue that paraffin embedding is crossed, and also can do microarray research to flesh tissue.
For achieving the above object, the technical solution of the utility model is as follows: carriage has been fixedly connected in the bottom of framework, be provided with a plurality of tubing strings in the carriage, be provided with the collet that is connected with carriage bottom pull in the lower end of tubing string, in framework, also be provided with a plurality of with keep a grip on the post core that is used, an end of these post cores all is fixedly connected with fixed head, the other end inserts in the tubing string respectively, also be fixedly connected with pull bar on fixed head, upper end and handle that framework is stretched out in the upper end of this pull bar are fixedly connected.
The beneficial effects of the utility model are:
1, the microarray that can disposablely carry out dozens of, hundreds of, thousands of relevant tissues is arranged and correlative study.The sample size of disposable like this processing is many, and treatment conditions are the same, and disturbing factor is few, error is little, and is during comparative study, scientific strong; Contain much information; Increase work efficiency, save the working time; Reduce the chemical reagent consumption, reduce operation steps and running time, economize on the use of funds, save labour and research cost.
2, on usable range, both can be used for the microarray research of the tissue of paraffin embedding processing; Can be used for the microarray research of flesh tissue (handling) again through fixing; Also can be used for the research of aspects such as the tissue Microarray research of tissue, animal, plant such as histology, histochemistry, immunohistochemistry, in situ hybridization, original position PCR.
3, compare many, the time saving and energy saving resources of the tissue of disposable processing, array of figure marshalling with existing single needle single tube kind value instrument.
Description of drawings
Accompanying drawing 1 is the utility model structural representation.
Accompanying drawing 2 is the utility model user mode synoptic diagram.
Among the figure, 1, handle, 2, scale, 3, pull bar, 4, fixed head, 5, the post core, 6, framework, 7, tubing string, 8, carriage, 9, collet, 10, joist.
Embodiment
The accompanying drawing that provides is in conjunction with the embodiments further specified its structure:
As Fig. 1 in conjunction with shown in Figure 2, in the bottom of framework 6 by the welding carriage 8 that has been fixedly connected, be arranged with a plurality of tubing strings 7 in the carriage 8, the fixed form of these tubing strings in carriage 8 is to do the diffusing point-like close and firm welding of side between tubing string and the tubing string, and the tubing string and the carriage of both sides are welded to connect.Be provided with collet 9 in the lower end of tubing string 7, collet 9 is horizontally placed on the joist 10 (inwardly be converted into the right angle by carriage 8 both sides hypomeres, form joist), to guarantee being organized in the processed process in the tubing string 7, can not come off voluntarily.Also be provided with a plurality of post cores 5 that are used with tubing string 7 in carriage 8, the upper end of these post cores 5 all is fixedly connected with fixed head 4, and insert respectively in the tubing string 7 lower end.Be fixed with pull bar 3 on fixed head 4, top and handle 1 that framework 6 is stretched out in the upper end of this pull bar 3 are fixedly connected.On pull bar 3, be provided with the scale 2 that is used for display column's core 5 insertion tubing strings 7 positions.Be to increase the contact area of tissue and treating fluid (dewatering agent, clarifier, paraffin solution), improve and promote the dehydration, transparent and invade wax of processed tissue, all digging on framework 6, collet 9 and tubing string 7 has many cellular apertures.
Present embodiment in use, method is as follows:
1, the tissue of handling with paraffin embedding carries out microarray and arranges:
1., determine to pick in advance the length and the diameter (generally long 3mm, diameter 1.5mm-3mm) of tissue, and select to organize the tactical deployment of troops accordingly and organize post group number, determine well putting in order of selected tissue.
2., with organizing the selecting and purchasing pin to take to determine the post of organizing of specification at the position of should selecting of alternative (donor) wax stone, be transplanted in the column jecket of micro-array tissue kind value instrument to the last one in order.
3., build the collet of plantation instrument.
4., will plant instrument invaded in the wax liquid about 10-20 minute.
5., embedding is a small amount of with paraffin liquid on an embedding is toppled on flat board, thick about 2-3mm, immediately that waxdip is good kind value instrument moves on to the top slightly of embedding paraffin liquid, extract collet rapidly out, after instrument keeps steady plantation, depress the post core gently, mention the plantation instrument simultaneously, organizing in the disposable wax liquid of planting half curdled appearance of post in the post core.
6., rapidly around the wax liquid of planting tissue, the embedding basket is installed, and pour fusion into about 60-65 degree centigrade embedding wax liquid, after about 5-10 minute, wax liquid solidifies, and forms many micro-array tissues wax stone.
7., after freezing many micro-array tissues wax stone and the section, carry out the microarray research work that needs.
2, doing microarray with the fixing tissue of fresh process arranges.
1., determine research contents, preliminary election tissue types and quantity and distributing order.
2., the tissue of preliminary election is cut into and organize the consistent shape and size of tubing string (with the post core of just packing into the degree of being that do not come off voluntarily again).And pack into successively according to the order that designs and to organize in the tubing string, finish until whole fillings.
3., install collet.
4., routinely to the tissue in the tubing string dewater, transparent, waxdip handles.
5., by 5. above-mentioned-7. the operation getting final product.
Claims (3)
1, a kind of biological tissue micro array chip instrument of arranging, has tubing string (7), post core (5), it is characterized in that: described tubing string (7) has a plurality of, arrangement is fixed in the carriage (8), be provided with the collet (9) that is connected with carriage (8) bottom pull in the lower end of tubing string (7), carriage (8) is fixed on the bottom of framework (6), in framework (6), also be provided with described post core (5), post core (5) is a plurality of, be used with tubing string (7), the upper end of this post core (5) all is fixedly connected with fixed head (4), insert respectively in the tubing string (7) lower end, be fixed with pull bar (3) on fixed head (4), upper end and handle (1) that framework (6) is stretched out in the upper end of this pull bar (3) are fixedly connected.
2, the biological tissue micro array chip according to claim 1 instrument of arranging, it is characterized in that: described pull bar (3) is provided with scale (2).
3, the biological tissue micro array chip according to claim 1 instrument of arranging is characterized in that: be equipped with cellular aperture on described framework (6), carriage (8), collet (9) and the tubing string (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02255290 CN2578830Y (en) | 2002-11-15 | 2002-11-15 | Micro-array chip configurating device of biological tissue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02255290 CN2578830Y (en) | 2002-11-15 | 2002-11-15 | Micro-array chip configurating device of biological tissue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2578830Y true CN2578830Y (en) | 2003-10-08 |
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ID=33723814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02255290 Expired - Fee Related CN2578830Y (en) | 2002-11-15 | 2002-11-15 | Micro-array chip configurating device of biological tissue |
Country Status (1)
| Country | Link |
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| CN (1) | CN2578830Y (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100451649C (en) * | 2004-01-08 | 2009-01-14 | 中南大学湘雅医学院肿瘤研究所 | Cell chip manufacturing method and its device |
| CN101187604B (en) * | 2007-12-14 | 2011-06-15 | 大连医科大学 | Freezing and paraffin embedded tissue chip production device |
| CN107338288A (en) * | 2017-06-14 | 2017-11-10 | 杨华卫 | A kind of biomolecule detecting method |
-
2002
- 2002-11-15 CN CN 02255290 patent/CN2578830Y/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100451649C (en) * | 2004-01-08 | 2009-01-14 | 中南大学湘雅医学院肿瘤研究所 | Cell chip manufacturing method and its device |
| CN101187604B (en) * | 2007-12-14 | 2011-06-15 | 大连医科大学 | Freezing and paraffin embedded tissue chip production device |
| CN107338288A (en) * | 2017-06-14 | 2017-11-10 | 杨华卫 | A kind of biomolecule detecting method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |