CN2270505Y - Long-acting Chinese medicinal herb plaster for curing kidney disease - Google Patents

Abstract

The utility model relates to a long-acting Chinese medicinal herb plaster for curing kidney diseases. The utility model is composed of a medical adhesive layer (1), absorbent cotton (2) which forms a special shape and is dipped with medicine liquid, porous gauze (3) for fixing the absorbent cotton, and a protective layer (4) and a reservoir (5) attached on the protective layer. The long-acting Chinese medicinal herb plaster for curing kidney diseases has the advantages of increase of medicine effect duration, reduction of material consumption, and increase of the action of transdermal absorption. The long-acting Chinese medicinal herb plaster for curing kidney diseases is a liquid preparation added with a penetration enhancer. The purpose of external treatment for inner diseases is achieved. The long-acting Chinese medicinal herb plaster for curing kidney diseases does not have any poisonous and side function through clinic comparative study. Notable curative effects are achieved for treating chronic nephritis, nephrotic syndrome, chronic renal failure, etc. The utility model has the advantages of convenient fabrication, low cost, and convenient operation.

Description

A kind of long-acting Chinese herbal medicine patch for the treatment of nephropathy

This utility model relate to a kind of treat multiple nephropathy extract the refining long-acting patch that forms by vegetable Chinese herbal medicine.

Learn according to literature search, application number is 93101615, denomination of invention is the patent application of a kind of body strong reinforcing kidney and pain stop ointment and method for making thereof, its disclosed content is a kind of body strong reinforcing kidney and pain stop ointment, it is that medicine is made extractum, be applied on the carrier and form, contain the Cortex Eucommiae, Radix Notoginseng, Radix Dipsaci, Fructus Chaenomelis, Lignum Pini Nodi, Cortex Acanthopancis, Radix Achyranthis Bidentatae, Ramulus Cinnamomi and Moschus.Its advantage is to use simply, convenience, reaches the effect of external treatment pain relieving and treatment by oral administration of medicines body strong reinforcing kidney as external-applied ointment.Its shortcoming is: 1, the effective drug duration of an obedient ointment can only be a fixedly effective drug duration of unit, can not prolong or double; 2, ointment is a semi-solid preparation, and the liquid preparation of the more identical composition of Transdermal absorption effect is poor; When 3, containing due viscosifier of ointment such as Colophonium etc., skin there are zest or sensitization, if no viscosifier then are difficult for being close on the skin.

The purpose of this utility model is to provide a kind of long-acting liquid type in order to overcome above-mentioned shortcoming, has no side effect and receives the Chinese herbal medicine patch of significant curative effect in treatment aspect the nephropathy.

The purpose of this utility model be achieved in that a kind of long-acting Chinese herbal medicine patch for the treatment of nephropathy by medical glue layer (1), be soaked with the given shape absorbent cotton (2) of medicinal liquid, fixedly porous gauze (3), the protective layer (4) of absorbent cotton and the reservoir (5) that is attached on the protective layer are made (seeing Fig. 1～3).

Medical glue layer adopts the medical elastic adhesive plaster to be cut into Fig. 1～3 (1) shapes and makes.

The given shape absorbent cotton that is soaked with medicinal liquid is to be cut into Fig. 1～3 (2) shapes with medical absorbent cotton, soaks in the medicinal liquid that makes, and picks up to not dripping for degree, is pasted on medical glue layer (1) central authorities then and makes.

Medicinal liquid prescription consists of: Fructus Cnidii 5～8%, Herba Epimedii 4～9%, Semen Vaccariae 7～12%, Fructus Lycii 10～15%, Placenta Hominis 4～9%, Concha Ostreae 16～19%, Radix Ginseng Rubra 2～11%, Gryllotalpa 3～10%, rule grass 2～4%, Folium Isatidis 8～17%, Radix Et Rhizoma Rhei 10～15%, Radix Glycyrrhizae 1～3%, azone are an amount of.Get 10 kilograms of Chinese herbal medicine by each components in proportions nominal in the above-mentioned prescription, the finished fluid of making is 5.38 kilograms, be that the finished fluid weight ratio that above-mentioned medical material amount is made with it is 1: 0.538, add the azone after ethanol dilutes in the finished fluid, making its concentration is 1.9～3%.In the prescription, Fructus Cnidii is the fruit of samphire cnidium monnieri, originates in the most of area of China, and sour in the mouth, cold in nature, nontoxic has the merit of warming the kidney to activate YANG, dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching, and androgen-like action is arranged.Herba Epimedii is the stem and leaf of Berberidaceae plant arrow leaf Herba Epimedii, originates in ground such as Zhejiang, Anhui, Guangdong, and Xin Gan, warm in nature, nontoxic has the merit of kidney invigorating and YANG supporting, expelling wind and removing dampness, and hypotensive effect is arranged.Semen Vaccariae is the seed of pinkwort Vaccaria segetalis, originates in China various places, and bitter in the mouth, property are flat, nontoxic, the merit of have that promoting the circulation of blood is stimulated the menstrual flow, diuresis, detumescence being held back skin ulcer.The structure Fructus Lycii is the mature fruit of matrimony vine of solanaceae plant, originates in the most of area of China, and sweet in the mouth, property are flat, nontoxic, the merit that has nourishing kidney, nourishing the essence and strengthening QI, tonifying liver to make eye bright, and hypotensive effect is arranged.Placenta Hominis is healthy people's a Placenta Hominis, and is sweet salty, warm in nature, nontoxic, QI invigorating is arranged, nourishes blood, the merit of benefit essence, and the effect of enhancing body resistance is arranged.Concha Ostreae is the shell of Ostreidae animal Crassostrea rivularis, originates in ground such as Guangdong, Fujian, Shandong coastal waters, and salty in the mouth, cool in nature, nontoxic has the merit of yin fluid astringing, YANG hyperactivity suppressing, arresting seminal emission, softening the hard mass.Radix Ginseng Rubra is the root of Araliaceae Radix Ginseng, originate in ground such as Heilungkiang, Jilin, Liaoning, sweet little hardship, warm in nature, nontoxic, strongly invigorating primordial QI is arranged, take off the merit of promoting the production of body fluid, calming the nerves admittedly, and significant antifatigue effect arranged, positivity nitrogen balance, protein synthesis to animal have facilitation, and the ratio of plasma albumin and globulin is risen.Gryllotalpa is the dry Scorpio of Gryllotalpidae insecticide Gryllotalpa, originates in the most of area of China, and salty in the mouth, cold in nature, nontoxic has the merit of diuretic relieving constipation.Rule grass is the herb of moraceae plants rule grass, and it is most of regional to originate in China, and sweet in the mouth, cold in nature, nontoxic has the merit of heat-clearing and toxic substances removing, diuresis repercussive.Folium Isatidis is the branch and leaf of Verenaceae plant Herba Diclipterae Chinensis, main product in the Hunan, ground such as Hubei, Guangxi, bitter in the mouth, cold in nature, nontoxic has the merit of heat-clearing and toxic substances removing, cooling blood for hemostasis.Radix Et Rhizoma Rhei is a polygonaceae plant Rheum officinale rhizome, originates in ground such as Hubei, Sichuan, Yunnan, and bitter in the mouth, cold in nature, nontoxic has that the poison of purging heat, removing mass stagnate, the merit of clots absorbing blood, and antitumor action is arranged.Radix Glycyrrhizae is the root and the root stock of glycyrrhizic legume, main product in the Inner Mongol, ground such as Gansu, Xinjiang, the merit with middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription is arranged, Radix Glycyrrhizae has detoxifcation, antiinflammatory, antiallergic action, antitumor and anti-various bacteria effect.The traditional Chinese medical science thinks, chronic nephritis is deficiency of spleen-YANG and kidneyYANG, the deficiency of vital energy or the hepatic and renal YIN deficiency and give birth to; Nephrotic syndrome is due to deficiency of spleen-YANG and kidneyYANG, the deficiency of vital energy; Chronic renal failure is many to form due to the poison because of being stranded in deficiency of spleen-YANG and kidneyYANG, the turbid damp, changing; Prostatitis belongs to categories such as the traditional Chinese medical science " nebulousurine ", " lumbago due to renal deficiency ", due to a little less than damp invasion of lower energizer, coagulation of QI-blood, the deficiency of kidney-QI.So treatment should be used warming and recuperating the spleen and kidney, enriching yin boost qi, removing dampness the turbid descending, promoting blood circulation to remove obstruction in the collateral, inducing diuresis to remove edema, clearing away heat and cooling blood medicine.In this medicinal liquid prescription, Fructus Cnidii, Herba Epimedii warming and recuperating the spleen and kidney, Fructus Lycii, Placenta Hominis, Radix Ginseng Rubra, enriching yin boost qi, Fructus Cnidii, Radix Et Rhizoma Rhei removing dampness the turbid descending, Semen Vaccariae, Radix Et Rhizoma Rhei promoting blood circulation to remove obstruction in the collateral, are restrained careless inducing diuresis to remove edema at Gryllotalpa, Folium Isatidis, the careless heat-clearing and toxic substances removing removing heat from blood of rule, assistant makes with Radix Glycyrrhizae, strengthens the merit and the coordinating the actions of various ingredients in a prescription of detoxifcation, plays good effect altogether.Meet method of treatment such as chronic nephritis, nephrotic syndrome, chronic renal failure and prostatitis.And kidney is positioned at the lumbar spinal column both sides, and left upper pole of kidney is put down 11 thoracic vertebras, and the lower end flushes with the 2nd lumbar vertebra, and right upper pole of kidney is put down the 12nd thoracic vertebra, extremely flat down the 3rd lumbar vertebra, and two kidneys move up and down 2～3 centimetres during breathing.Effects such as tonifying YANG consolidates, kidney tonifying gas, sharp waist knee joint are arranged when Zhishi, shen shu irriate, cure mainly suffer from a deficiency of the kidney, nephritis, prostatitis, urine retention, seminal emission, premature ejaculation, sexual impotence, chronic low back pain, asthenia universalis etc.Report is arranged, stimulate the bilateral SHENYU acupoint when nephritis, patient's kidney function is obviously increased, phenol red output is than also showed increased before stimulating, and red in patient's urine, leukocyte and albumen also reduce even disappears, blood pressure drops, and edema alleviates.This effect of stimulation generally can be kept a few hours, can last for days sometimes.Zhishi location: foreign side under the second lumbar vertebra spinous process, other 3 cun of governor vessel, the proper kidney in deep, acupuncture point; Shen shu location: between second and third spinous process of lumbar vertebra, the side is opened 1.5 cun, the deep, acupuncture point is bilateral hilus renalis place, rich blood vessel, therefore, adopt the absorbent cotton of Fig. 1～2 (2) shapes to be affixed on relevant position, kidney district, the left and right sides, absorbent cotton has also been aimed at the Zhishi and the SHENYU point of human body just, effective ingredient with good transdermal effect penetrates acupuncture point and kidney performance therapeutical effect easily, to reach the inner disease outer treat purpose.More than show: the prescription of this medicinal liquid reaches and sticks administration with this given shape absorbent cotton is reasonable and science.

The technological process for preparing this medicinal liquid is:

Fixedly the porous gauze of absorbent cotton is to be cut into Fig. 1～3 (1) shapes with hospital gauze, covers be soaked with on the given shape absorbent cotton (2) of medicinal liquid, and porous gauze periphery is pasted on the medical glue layer (1), and the given shape absorbent cotton that is soaked with medicinal liquid is fixed.

Protective layer and reservoir attached to it adopt polyethylene film to be cut into Fig. 1～3 (4) shapes and add in central authorities and do a reservoir (5) and make.Protective layer covers and is being soaked with on the given shape absorbent cotton of medicinal liquid, and periphery clings with medical glue layer, and the sealing of messenger drug cotton-wadded quilt is preserved, and like this, protective layer can prevent medical glue layer oxidative degradation, can prevent the medicinal liquid volatile dry of absorbent cotton again.Open protective layer during use, the given shape absorbent cotton that is soaked with medicinal liquid is attached to relevant position, kidney district, the patient left and right sides, at this moment, Zhishi and SHENYU point that absorbent cotton has also been aimed at the patient just stick.Be full of medicinal liquid in the reservoir, the given shape absorbent cotton of waiting to be soaked with medicinal liquid tears the reservoir opening after sticking and killing to medicinal liquid, allows the moistening absorbent cotton of medicinal liquid, can stick once again again.

The concrete structure of utility model and manufacture method are provided by following three embodiment and accompanying drawing thereof.

Embodiment one: Fig. 1 is the profile that is affixed on the long-acting Chinese herbal medicine patch on left kidney district and the corresponding acupuncture point.

Illustrate according to concrete structure and the manufacture method that the utility model proposes below in conjunction with Fig. 1.

Be affixed on long-acting Chinese herbal medicine patch on left kidney district and the corresponding acupuncture point comprise one deck medical glue layer (1), one be soaked with the fabiform absorbent cotton (2) of medicinal liquid, one deck fixedly absorbent cotton porous gauze (3), layer protective layer (4) and be attached to a reservoir (5) on the protective layer.

Medical glue layer adopts the medical elastic adhesive plaster to be cut into Fig. 1 (1) shape and makes.

Be soaked with the fabiform absorbent cotton method for making of medicinal liquid: press Fructus Cnidii 8%, Herba Epimedii 9%, Semen Vaccariae 8%, Fructus Lycii 11%, Placenta Hominis 5%, Concha Ostreae 16%, Radix Ginseng Rubra 5%, Gryllotalpa 7%, rule grass 4%, Folium Isatidis 14%, Radix Et Rhizoma Rhei 12%, Radix Glycyrrhizae 1% percentage by weight takes by weighing totally 0.1 kilogram of medical material, medicinal liquid 53.8ml is made in technological process according to this medicinal liquid of preparation, all adorn in two containers, be cut into Fig. 1 (2) shape with the medical absorbent cotton of 0.3 cm thick, putting into a container medicinal liquid after the sterilization soaks into, pick up to not dripping, be pasted on medical glue layer (1) central authorities then for degree.

Fixedly the porous gauze of absorbent cotton is to be cut into Fig. 1 (3) shape with hospital gauze, covers be soaked with on the fabiform absorbent cotton (2) of medicinal liquid, and porous gauze periphery is pasted on the medical glue layer (1), and the fabiform absorbent cotton that is soaked with medicinal liquid is fixed.

Protective layer and reservoir attached to it adopt polyethylene film to be cut into Fig. 1 (4) shape and add in central authorities and do a reservoir (5) and make, and reservoir is done an opening, are adjacent to the opening viscose glue after another container medicinal liquid is filled reservoir.Another cover of protective layer is being soaked with on the fabiform absorbent cotton of medicinal liquid, and periphery clings with medical glue layer.

Embodiment two: Fig. 2 is the profile that is affixed on the long-acting Chinese herbal medicine patch on right kidney district and the corresponding acupuncture point.

Illustrate according to concrete structure and the manufacture method that the utility model proposes below in conjunction with Fig. 2.

Be affixed on long-acting Chinese herbal medicine patch on right kidney district and the corresponding acupuncture point comprise one deck medical glue layer (1), one be soaked with the fabiform absorbent cotton (2) of medicinal liquid, one deck fixedly absorbent cotton porous gauze (3), layer protective layer (4) and be attached to a reservoir (5) on the protective layer.

Medical glue layer adopts the medical elastic adhesive plaster to be cut into Fig. 2 (1) shape and makes.

Be soaked with the fabiform absorbent cotton method for making of medicinal liquid: press Fructus Cnidii 8%, Herba Epimedii 9%, Semen Vaccariae 8%, Fructus Lycii 11%, Placenta Hominis 5%, Concha Ostreae 16%, Radix Ginseng Rubra 5%, Gryllotalpa 7%, rule grass 4%, Folium Isatidis 14%, Radix Et Rhizoma Rhei 12%, Radix Glycyrrhizae 1% percentage by weight takes by weighing totally 0.1 kilogram of medical material, medicinal liquid 53.8ml is made in technological process according to this medicinal liquid of preparation, all adorn in two containers, be cut into Fig. 2 (2) shape with the medical absorbent cotton of 0.3 cm thick, putting into a container medicinal liquid after the sterilization soaks into, pick up to not dripping, be pasted on medical glue layer (1) central authorities then for degree.

Fixedly the porous gauze of absorbent cotton is to be cut into Fig. 2 (3) shape with hospital gauze, covers be soaked with on the fabiform absorbent cotton (2) of medicinal liquid, and porous gauze periphery is pasted on the medical glue layer (1), and the fabiform absorbent cotton that is soaked with medicinal liquid is fixed.

Protective layer and reservoir attached to it adopt polyethylene film to be cut into Fig. 2 (4) shape and add in central authorities and do a reservoir (5) and make, and reservoir is done an opening, are adjacent to the opening viscose glue after another container medicinal liquid is filled reservoir.Another cover of protective layer is being soaked with on the fabiform absorbent cotton of medicinal liquid, and periphery clings with medical glue layer.

Embodiment three: Fig. 3 is the profile that is affixed on the long-acting Chinese herbal medicine patch on the cv acupuncture point.

Illustrate according to concrete structure and the manufacture method that the utility model proposes below in conjunction with Fig. 3.

Be affixed on long-acting Chinese herbal medicine patch on the cv acupuncture point comprise one deck medical glue layer (1), one be soaked with the garden shape absorbent cotton (2) of medicinal liquid, one deck fixedly absorbent cotton porous gauze (3), layer protective layer (4) and be attached to a reservoir (5) on the protective layer.

Medical glue layer adopts the medical elastic adhesive plaster to be cut into Fig. 3 (1) shape and makes.

Be soaked with the garden shape absorbent cotton method for making of medicinal liquid: take by weighing totally 0.1 kilogram of medical material by Fructus Cnidii 6%, Herba Epimedii 9%, Semen Vaccariae 10%, Fructus Lycii 14%, Placenta Hominis 4%, Concha Ostreae 17%, Radix Ginseng Rubra 8%, Gryllotalpa 9%, rule grass 3%, Folium Isatidis 8%, Radix Et Rhizoma Rhei 9%, Radix Glycyrrhizae 3% percentage by weight, medicinal liquid 53.8ml is made in technological process according to this medicinal liquid of preparation, all adorn in two containers, be cut into Fig. 3 (2) shape with the medical absorbent cotton of 0.3 cm thick, putting into a container medicinal liquid after the sterilization soaks into, pick up to not dripping, be pasted on medical glue layer (1) central authorities then for degree.

Fixedly the porous gauze of absorbent cotton is to be cut into Fig. 3 (3) shape with hospital gauze, covers be soaked with on the garden shape absorbent cotton (2) of medicinal liquid, and porous gauze periphery is pasted on the medical glue layer (1), and the garden shape absorbent cotton that is soaked with medicinal liquid is fixed.

Protective layer and reservoir attached to it adopt polyethylene film to be cut into Fig. 3 (4) shape and add in central authorities and do a reservoir (5) and make, and reservoir is done an opening, are adjacent to the opening viscose glue after another container medicinal liquid is filled reservoir.Another cover of protective layer is being soaked with on the garden shape absorbent cotton of medicinal liquid, and periphery clings with medical glue layer.

The utlity model has following advantage:

1, increases effective drug duration, reduce material consumption.

One obedient ointment can only apply once by card, therefore has only a fixedly effective drug duration of unit.This utility model adds in protective layer central authorities does a reservoir; be full of medicinal liquid in the capsule; the given shape absorbent cotton that is soaked with medicinal liquid sticks when medicinal liquid is killed; the effective drug duration of an existing unit; at this moment, tear the reservoir opening, make the moistening absorbent cotton of medicinal liquid; can stick again once again, increase the effective drug duration of a unit.And absorbent cotton and medical viscose glue use secondary, have reduced consumption.

2, make the liquid preparation that is added with penetration enhancer, increase the Transdermal absorption effect.

This utility model is that Chinese herbal medicine is made medicinal liquid, adds the osmosis promoter azone that increases Transdermal absorption in the medicinal liquid, sticks acupuncture point or kidney district by the given shape absorbent cotton that is soaked with medicinal liquid, makes medicinal liquid penetrate performance drug action in the body, reaches the inner disease outer treat purpose.

3, have no side effect.

This utility model does not contain cohesiveness substrate and other filleies such as Colophonium, has reduced the factor that skin is had zest or sensitization.

Clinical observation through animal experiment and 80 routine nephropathy patients or test volunteer proves that this plaster has no side effect.Concrete grammar is:

(1) skin irritation test: 5 of year healthy rabbit of hanking, 2～2.5 kilograms of body weight, took off tame rabbit back spinal column diamond wool in preceding 24 hours in administration, the depilation area is body surface area about 10% (about 150 square centimeters), and every rabbit left side sticks the plaster that is soaked with medicinal liquid, and the right side sticks the absorbent cotton that is soaked with distilled water, kept 24 hours, after treating that absorbent cotton liquid is killed, reuse medicinal liquid and the moistening absorbent cotton of distilled water stick once more respectively.Removed in 48 hours and stick the back and observe and stick the position and have or not situations such as erythema or edema.The result shows: the place of sticking, depilation district, every rabbit both sides does not all have erythema, edema or other emerging erythra.

(2) animal acute toxicity test: select 16 of adult healthy rabbit for use, male and female half and half, 2.3～2.8 kilograms of body weight are divided 4 groups at random, 4 every group.Took off tame rabbit back left of spine hair in preceding 24 hours in sticking, the unhairing area is body surface area about 5% (about 75 square centimeters).First group sticks the plaster after 24 hours that is soaked with medicinal liquid, takes off again moistening sticking again after 24 hours and remove plaster; Second group sticks after 72 hours and removes plaster, moistening 2 times therebetween; The 3rd group sticks after 96 hours and removes plaster, and moistening therebetween 3 times, the 4th group sticks the absorbent cotton that is soaked with distilled water and take off after 24 hours and moisteningly once stick again, removes after 48 hours.Observe every day and organize respectively that rabbit has or not death, overall health of patients, body weight, extremity are movable and to stick variation such as skin place, continuous 14 days, the result shows: 4 groups of rabbit all survive, and each organizes overall health of patients, body weight, extremity are movable and stick the skin place there is no notable difference.Select 10 rabbit else, every of every day in feedstuff, add medicinal liquid 10ml and fed 21 days, behind the medicine all rabbit all survive.

(3) clinical observation 80 routine nephropathy patients or test volunteer use this utility model to stick the kidney district and reach or the cv acupuncture point, and every day 1 time, 14 days is a course of treatment, continuously 2-4 the course of treatment, there is no obvious poison and pays effect.

4, this utility model is being received significant curative effect aspect the treatment nephropathy.Administrated method and clinical test results are as follows:

(1) clinical data and method: non-dialysis chronic renal failure (CRF) patient 58 examples, divide two groups at random, matched group 28 examples, man's 16 examples, women 12 examples, 19～56 years old age, the course of disease 0.3～20 year, the cause of disease are chronic nephritis (CGN), low protein diet (LPD), support symptomatic treatment 3 months.Plaster group 30 examples, male 17 examples, women 13 examples, 20～67 years old age, the course of disease 1.2～20 years, the cause of disease is CGN, except that LPD, support symptomatic treatment, adds with 1 subsides of this plaster in per 2 days, and be 14 days the course of treatment, continuous 2～4 courses of treatment.

The CGN60 example is divided two groups at random, plaster group 30 examples, and male 16 examples, women 14 examples, at 19～56 years old age, the course of disease 1～7 year added with 1 subsides of this plaster in per 2 days, and be 14 days the course of treatment, continuous 2～4 courses of treatment; Matched group 30 examples, each 15 example of men and women, 19～55 years old age, the course of disease 1.1～6 years, oral dexamethasone (Dex.) 1mg/Kg/d, 3 months courses of treatment.

Nephrotic syndrome (NS) 40 examples are divided two groups at random, plaster group 20 examples, and NSI type 15 examples wherein, II type 5 examples at 14～40 years old age, were pasted 14 days courses of treatment, continuous 6 courses of treatment with this plaster 1 in per 2 days; Matched group 20 examples, NSI type 14 examples wherein, II type 6 examples, at 13～40 years old age, oral Dex.1mg/Kg/d begins decrement after medication to 8 week (w), 3 months courses of treatment.

Observe symptom of digestive tract, mean arterial pressure (diastolic pressure+1/3 pulse pressure before and after CRF patient's medicine, MAP), anemia, psychoneurosis shape, respiratory symptom, skin itching and twenty-four-hour urine amount improvement percentage rate, and survey blood urea nitrogen (BUN), serum creatinine (SCr), endogenous creatinine clearance rate (CCr), calcium (Ca), phosphorus (P), two groups of medicine the last fortnights begin, every 2w surveys SCr once, with the calculating of statistics return law of the straight line and with 1/SCr the time (w) is mapped.Survey MAP, body weight (Wei), twenty-four-hour urine protein quantification (24hupq), total serum protein (TP), albumin (Al), BUN, SCr, potassium (K), sodium (Na) before and after CGN and the NS patient's medicine.

(2) result: plaster group symptom of digestive tract, MAP, anemia, psychoneurosis shape, respiratory symptom, skin itching and urine amount improvement percentage rate (are respectively 87%, 82%, 71%, 81%, 80%, 82%, 83% behind the CRF patient treatment, n=30) all be significantly higher than matched group (42%, 42%, 22%, 20%, 42%, 21%, 42%, n=28) (P＜0.05).

Every index variation sees Table 1 before and after two groups of CRF patient treatments.

Table 1: every index variation before and after two groups of CRF patient treatments (x ± s)

Plaster group (n=30) matched group (n=28) observation item

BUN (mmol/l) 28.9 ± 11.3 18.2 ± 8.3b 25.6 behind the medicine prodrug behind the medicine prodrug ± 11.2 22.0 ± 10.5cSCr (umol/l), 1297 ± 450 721 ± 260b, 1001 ± 361 971 ± 310cCCr (ml.s-1/1.73m2), 5.7 ± 3.8 19.2 ± 9.3b, 6.8 ± 4.1 8.1 ± 6.1cCa (mmol/l), 1.6 ± 0.4 2.1 ± 0.4a, 2.0 ± 0.3 2.1 ± 0.3cP (mmol/l), 1.9 ± 0.7 1.3 ± 0.5a, 1.6 ± 1.1 1.50 ± 0.9c24hupq (mg/24h), 1983 ± 1,010 930 ± 520b, 2030 ± 1,221 2010 ± 1428c

With a.p＜0.05 relatively before the medicine on the same group, b.p＜0.01, c.p＞0.05 (t check)

The two groups of CRF patient's renal functioies in treatment back change sees Fig. 4.

As calculated, straight slope (regression coefficient) mean (b) ± standard deviation (s) is respectively-0.01931 ± 0.00159 and-0.01881 ± 0.00182 before and after the plaster group medicine, and there were significant differences for both (p＜0.01); Matched group b ± s same period is respectively-0.01916 ± 0.00899 and-0.018989 ± 0.00883, and both do not have significant difference (p＞0.05); The preceding two groups of b ± s of medicine do not have significant difference (p＞0.05), and (p＜0.02) is then arranged behind the medicine.

Every index variation sees Table 2 before and after two groups of CGN patient treatments.

Table 2: every index variation before and after two groups of CGN patient treatments (x ± s)

Plaster group (n=30) matched group (n=30) observation index

MAP （ Kpa ） 17.2±2.4 13.6±2.2a 15.7±3.1 14.8±2.9cWei （ Kg ） 61.3±10.8 50.0±9.1a 59.9±18.7 46.8±11.6a24hupq （ mg／24h ） 2590±1621 860±310b 2567±1810 630±131bTP （ g／l ） 53.6±16.7 69.6±18.1a 55.3±16.8 73.5±16.2aAl （ g／l ） 31.7±13.9 40.9±15.1a 34.9±14.2 48.3±14.0aSCr （ umol／l ） 187±86 104±52a 178±77 167±67cBUN （ mmol／l ） 8.9±5.1 4.3±2.2a 7.1±4.1 6.8±3.3cK （ mmol／l ） 5.5±1.6 4.3±0.8c 5.4±＋1.1 4.8±1.0cNa （ mmol／l ） 156±110 139±96c 159±120 145±108ca.p＜0.05； B.p＜0.01, and and and and and and the indices variation sees Table 3 before and after c.p＞0.05 (t check) two groups of NS patient treatments. Table 3:every index variation before and after two groups of NS patient treatments (x ± s)

Plaster group (n=20) matched group (n=20) observation index

MAP (Kpa) 16.8 ± 3.2 12.4 ± 1.9a, 15.2 ± 3.8 14.4 ± 2.2cWei (Kg) 71.3 ± 22.6 56.0 ± 15.8a 68.4 behind the medicine prodrug ± 19.9 47.0 ± 18.1b24hupq (mg/24h), 6351 ± 2,109 1860 ± 351b 6184 ± 2,008 1410 ± 290bTP (g/l), 31.4 ± 10.8 59.3 ± 17.7b 33.7 ± 12.6 61.6 ± 15.8bAl (g/l), 23.6 ± 15.7 41.4 ± 21.6a 30.8 behind the medicine prodrug ± 14.6 48.9 ± 23.5aSCr (umol/l), 176 ± 91 126 ± 57a, 156 ± 81 150 ± 61cBUN (mmol/l), 9.0 ± 4.4 4.0 ± 2.9a, 7.5 ± 4.9 7.2 ± 3.6cK (mmol/l), 5.4 ± 2.2 4.9 ± 1.1c, 5.2 ± 1.6 4.9 ± 1.7cNa (mmol/l), 151 ± 21 144 ± 16c, 149 ± 19 143 ± 11c

With a.p＜0.05 relatively before the medicine on the same group, b.p＜0.01, c.p＞0.05 (t check)

(3) clinical test results shows: this plaster can significantly be alleviated hypertension, anemia, skin itching, psychoneurosis shape and the respiratory symptom of non-dialysis CRF, increase the urine amount, significantly reduce BUN, SCr, P level, improve CCr, Ca level, and can significantly delay non-dialysis CRF progress.Clinical test results shows that still this plaster and Dex. all can significantly eliminate the edema of CGN and NS, alleviate albuminuria, thereby improves TP, AL level.Aspect the hypertension of alleviating CGN and NS, reduction BUN, SCr, this plaster is better than Dex..

5, make simply, with low cost, easy to use.

This utility model is that the given shape absorbent cotton that will be soaked with medicinal liquid is pasted on the medical viscose glue, fixedly the porous gauze of absorbent cotton covers on absorbent cotton again, porous gauze periphery is pasted on the adhesive-layer, absorbent cotton is fixed, the reservoir that will be attached on the protective layer is filled liquid at last, on absorbent cotton, periphery clings with medical glue layer with another cover of protective layer, makes simple; Material therefor is cheap, easily buying; Time spent is opened protective layer, absorbent cotton is aimed at kidney district or acupuncture point stick and get final product, and uses very convenient.

Claims (1)

1. A kind of long-acting Chinese herbal medicine patch for the treatment of nephropathy is characterized in that: it by medical glue layer (1), be soaked with the given shape absorbent cotton (2) of medicinal liquid, fixedly porous gauze (3), the protective layer (4) of absorbent cotton and the reservoir (5) that is attached on the protective layer are made.

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