CN220999647U - Bioreactor with disinfection function for cell fermentation - Google Patents
Bioreactor with disinfection function for cell fermentation Download PDFInfo
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- CN220999647U CN220999647U CN202322630412.0U CN202322630412U CN220999647U CN 220999647 U CN220999647 U CN 220999647U CN 202322630412 U CN202322630412 U CN 202322630412U CN 220999647 U CN220999647 U CN 220999647U
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- reactor
- main body
- bioreactor
- disinfection
- reactor main
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- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 36
- 238000000855 fermentation Methods 0.000 title claims abstract description 28
- 230000004151 fermentation Effects 0.000 title claims abstract description 28
- 230000007246 mechanism Effects 0.000 claims abstract description 15
- 239000007921 spray Substances 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 238000010438 heat treatment Methods 0.000 claims description 11
- 238000007789 sealing Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 3
- 230000007306 turnover Effects 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 6
- 230000002349 favourable effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005489 elastic deformation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model discloses a bioreactor with a disinfection function for cell fermentation, which comprises a reactor main body, a reactor cover, a temperature sensor and a limiting mechanism, wherein the reactor cover is clamped and installed at the upper end of the reactor main body, the temperature sensor is installed at the lower end of the reactor cover, the limiting mechanism is arranged at the edge of the reactor cover in an equal angle manner, a stirring rod is fixedly connected to the output end of a servo motor, and a disinfection spray nozzle is installed at the lower end of an annular pipeline in an equal angle manner. This bioreactor for cell fermentation with disinfection function, the inside environment of reactor main part is in the constant temperature state, is favorable to the fermentation of cell, and after the use, sprays the disinfection through annular duct and disinfection shower nozzle to the inside of reactor main part moreover, prevents that the bacterium from remaining, dismantles between reactor lid and the reactor main part through stop gear, is convenient for fully clear up the inside of reactor main part.
Description
Technical Field
The utility model relates to the technical field related to cell fermentation, in particular to a bioreactor with a disinfection function for cell fermentation.
Background
Cell fermentation refers to a process of generating and accumulating a large amount of metabolic products required for human fermentation by performing large-scale growth culture of microorganisms or animal and plant cells to generate chemical and physiological changes, and is usually performed in a corresponding bioreactor, which is an important place for cell fermentation;
Referring to China patent grant publication No. CN210117384U, grant publication No. 2020.02.28, a cell bioreactor is disclosed, the scheme has the vent port designed on the stirring shaft, the integrated design saves the effective volume of the device, thereby enlarging the utilization rate, the vent port is densely distributed at the bottom of the stirring shaft, the oxygen can be ensured to be fully dissolved in the nutrient solution, the diameter of the vent port is 1 mm, the flow and the flow velocity of the oxygen are controlled, and the oxygen partial pressure in the tank body is controlled;
However, in the prior art, after the reactor is used in the actual use process, residual bacteria are contained in the reactor, so that the reactor is inconvenient to sufficiently disinfect and clean, secondary use is affected, the temperature in the reactor is not constant enough, and the fermentation effect of cells is affected, and the problems exist in the above-listed comparison patents;
For this reason, a bioreactor for cell fermentation with disinfection function is proposed to solve the above problems.
Disclosure of utility model
The utility model aims to provide a bioreactor with a disinfection function for cell fermentation, which solves the problems that in the prior art, residual bacteria are contained in the reactor after the reactor is used in the actual use process, so that the interior of the reactor is inconvenient to sufficiently disinfect and clean, secondary use is affected, the temperature in the reactor is not constant enough, and the fermentation effect of cells is affected.
In order to achieve the above purpose, the present utility model provides the following technical solutions: a bioreactor with a disinfection function for cell fermentation comprises a reactor main body, a reactor cover which is clamped and installed at the upper end of the reactor main body, and a temperature sensor which is installed at the lower end of the reactor cover;
A sealing ring is arranged between the reactor main body and the reactor cover in a fitting way, and a discharge valve is arranged at the lower end of the reactor main body;
Further comprises:
The limiting mechanism is arranged at the edge of the reactor cover in an equal angle manner, is used for limiting the space between the reactor cover and the reactor main body, and drives the reactor cover to form a dismounting structure at the upper end of the reactor main body;
The stirring rod is fixedly connected to the output end of the servo motor, and the servo motor drives the stirring rod to rotate in the reactor main body;
The disinfection shower nozzle, the equiangular installation of disinfection shower nozzle is in the lower extreme of annular duct, and disinfection shower nozzle combines annular duct to disinfect the spraying in the reactor main part.
Preferably, the limiting mechanism comprises a fixed plate hinged at the edge of the upper end of the reactor cover, a connecting plate fixedly connected to the side surface of the upper end of the reactor main body, a fixed block used for limiting, a spring arranged in the fixed block, a protruding block fixedly connected to the movable end of the spring and a connecting rod fixedly connected to the upper end of the protruding block.
Preferably, the fixed plate forms a turnover structure at the upper end of the reactor cover, the fixed plate is connected with the connecting plate through a clamping groove, and the fixed plate and the connecting plate are limited through a fixed block.
Preferably, the fixing block is attached between the connecting plate and the fixing plate, and a sliding structure is formed between the fixing block and the protruding block.
Preferably, the convex blocks are connected with the fixing plate in a clamping way, and the convex blocks drive the connecting rods to be connected with the upper ends of the fixing blocks in a sliding way.
Preferably, a servo motor is fixedly arranged at the upper end of the reactor cover, an annular pipeline is fixedly connected to the middle part of the reactor cover, and the annular pipeline is connected with an external disinfection cylinder through a hose and a pump body.
Preferably, the side surface of the reactor main body is fixedly connected with a water tank, the interior of the water tank contains a proper amount of water, and the inner side wall of the water tank is provided with a heating device.
Compared with the prior art, the utility model has the beneficial effects that: according to the bioreactor with the disinfection function for cell fermentation, in the actual use process, the water tank and the heating device are used for heating the internal environment of the reactor main body in a water bath mode, so that the internal environment of the reactor main body is in a constant temperature state, fermentation of cells is facilitated, after the use is finished, the internal of the reactor main body is sprayed and disinfected through the annular pipeline and the disinfection spray nozzle, bacteria residues are prevented, the reactor cover and the reactor main body are detached through the limiting mechanism, and the internal of the reactor main body is convenient to clean fully;
1. The device is provided with a limiting mechanism, the limiting mechanism is arranged at the edge of the reactor cover in an equal angle manner, the limiting mechanism comprises a fixed plate, a connecting plate, a fixed block, a spring, a lug and a connecting rod, and the reactor cover and the reactor main body are convenient to detach through the arrangement of the limiting mechanism, so that the interior of the reactor main body is convenient to clean fully;
2. The water tank and the heating device are arranged, and the water in the water tank is heated through the heating device, so that the water bath heating is conveniently carried out on the internal environment of the reactor main body, the temperature in the reactor main body is more constant, and the fermentation of cells is facilitated;
3. Be equipped with annular duct and disinfection shower nozzle, the lower extreme of disinfection shower nozzle at annular duct is equiangular setting, carries out even spraying in to the reactor main part through the disinfection shower nozzle, is convenient for disinfect the inside of reactor main part, prevents that the bacterium from remaining to influence secondary use.
Drawings
FIG. 1 is a schematic view of the front cut-away structure of the present utility model;
FIG. 2 is an enlarged schematic view of the structure of FIG. 1A according to the present utility model;
FIG. 3 is a schematic view of the overall structure of the connection of the fixing plate and the connecting plate of the present utility model;
FIG. 4 is a schematic diagram of the front view of the connection of the fixing block, the bump and the connecting rod of the present utility model;
FIG. 5 is a schematic view showing the bottom view of the connection of the annular duct, the disinfection spray head and the reactor cover of the present utility model;
FIG. 6 is a schematic view showing the bottom structure of the reactor body, the reactor cover and the water tank connection according to the present utility model.
In the figure: 1. a reactor body; 2. a reactor cover; 3. a limiting mechanism; 4. a fixing plate; 5. a connecting plate; 6. a fixed block; 7. a spring; 8. a bump; 9. a connecting rod; 10. a seal ring; 11. a servo motor; 12. a stirring rod; 13. a discharge valve; 14. a temperature sensor; 15. a water tank; 16. a heating device; 17. an annular pipe; 18. and (5) sterilizing the spray head.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Referring to fig. 1-6, the present utility model provides a technical solution: a bioreactor with a disinfection function for cell fermentation comprises a reactor main body 1, a reactor cover 2, a limiting mechanism 3, a fixed plate 4, a connecting plate 5, a fixed block 6, a spring 7, a convex block 8, a connecting rod 9, a sealing ring 10, a servo motor 11, a stirring rod 12, a discharge valve 13, a temperature sensor 14, a water tank 15, a heating device 16, an annular pipeline 17 and a disinfection spray head 18.
When the bioreactor with the disinfection function for cell fermentation is used, as shown in fig. 1 and 6, a proper amount of cell culture is contained in the reactor main body 1, meanwhile, the upper end of the reactor main body 1 is clamped and provided with the reactor cover 2, a sealing ring 10 is arranged between the reactor cover 2 and the reactor main body 1 in a fitting way, the air tightness of the connection part of the reactor main body 1 and the reactor cover 2 is ensured, a stirring rod 12 is driven by a servo motor 11 to slowly rotate in the reactor main body 1, the cell culture in the reactor main body 1 is disturbed, meanwhile, the temperature in the reactor main body 1 is detected by a temperature sensor 14, when the temperature is lower, a heating device 16 arranged in a water tank 15 is started, the heating device 16 heats water in the water tank 15, so that the internal environment of the reactor main body 1 is conveniently heated in a water bath, the internal temperature of the reactor main body 1 is more constant, and meanwhile, the temperature of the reactor main body 1 can be kept warm, and the fermentation of cells is facilitated;
When the experiment is completed and needs to be disinfected, as shown in fig. 1 and 5, a disinfection spray head 18 is arranged at the lower end of the annular pipeline 17 at equal angles, the annular pipeline 17 is connected with a pump body and an external disinfection cylinder through a hose, and uniform disinfection spray is carried out on the reactor main body 1 through the disinfection spray head 18, so that bacteria residue can be prevented from affecting secondary use;
Through pulling connecting rod 9, connecting rod 9 drives lug 8 and slides in fixed block 6 for lug 8 extrudees spring 7, spring 7 takes place elastic deformation, lug 8 breaks away from with fixed plate 4, and then loosen spacing between fixed block 6 and the fixed plate 4, then upwards pull lug 8, take lug 8 out from between connecting plate 5 and the fixed plate 4, thereby loosen spacing between connecting plate 5 and the fixed plate 4, upset fixed plate 4 to the outside then, fixed plate 4 rotates in the upper end of reactor lid 2, fixed plate 4 breaks away from with connecting plate 5, then upwards pull reactor lid 2, and then be convenient for dismantle between reactor lid 2 and the reactor main part 1, simultaneously reactor lid 2 drives puddler 12 and takes out from the reactor main part 1, be convenient for fully clear up the inside of reactor main part 1 and puddler 12, make the reactor keep clean, convenient follow-up secondary use.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. A bioreactor for cell fermentation with a disinfection function comprises a reactor main body (1), a reactor cover (2) which is clamped and installed at the upper end of the reactor main body (1), and a temperature sensor (14) which is installed at the lower end of the reactor cover (2);
A sealing ring (10) is arranged between the reactor main body (1) and the reactor cover (2) in a fitting way, and a discharge valve (13) is arranged at the lower end of the reactor main body (1);
Characterized by further comprising:
The limiting mechanisms (3) are arranged at the edges of the reactor cover (2) at equal angles, the limiting mechanisms (3) are used for limiting the space between the reactor cover (2) and the reactor main body (1), and the limiting mechanisms (3) drive the reactor cover (2) to form a dismounting structure at the upper end of the reactor main body (1);
The stirring rod (12) is fixedly connected to the output end of the servo motor (11), and the servo motor (11) drives the stirring rod (12) to rotate in the reactor main body (1);
And the disinfection spray heads (18) are arranged at the lower end of the annular pipeline (17) at equal angles, and the disinfection spray heads (18) are combined with the annular pipeline (17) to carry out disinfection spraying on the reactor main body (1).
2. The bioreactor for cell fermentation with a sterilizing function according to claim 1, wherein: the limiting mechanism (3) comprises a fixing plate (4) hinged to the edge of the upper end of the reactor cover (2), a connecting plate (5) fixedly connected to the side face of the upper end of the reactor body (1), a fixing block (6) used for limiting, a spring (7) arranged in the fixing block (6), a protruding block (8) fixedly connected to the movable end of the spring (7) and a connecting rod (9) fixedly connected to the upper end of the protruding block (8).
3. A bioreactor for cell fermentation with disinfection function according to claim 2, wherein: the fixed plate (4) forms a turnover structure at the upper end of the reactor cover (2), the fixed plate (4) is connected with the connecting plate (5) through a clamping groove, and the fixed plate (4) is limited with the connecting plate (5) through a fixed block (6).
4. A bioreactor for cell fermentation with disinfection function according to claim 3, wherein: the fixing block (6) is arranged between the connecting plate (5) and the fixing plate (4) in a fitting mode, and a sliding structure is formed between the fixing block (6) and the protruding block (8).
5. The bioreactor for cell fermentation with a disinfection function according to claim 4, wherein: the lug (8) is connected with the fixing plate (4) in a clamping way, and the lug (8) drives the connecting rod (9) to be connected with the upper end of the fixing block (6) in a sliding way.
6. The bioreactor for cell fermentation with a sterilizing function according to claim 1, wherein: the upper end of the reactor cover (2) is fixedly provided with a servo motor (11), the middle part of the reactor cover (2) is fixedly connected with an annular pipeline (17), and the annular pipeline (17) is connected with an external disinfection cylinder through a hose and a pump body.
7. The bioreactor for cell fermentation with a sterilizing function according to claim 1, wherein: the side of the reactor main body (1) is fixedly connected with a water tank (15), the inside of the water tank (15) contains a proper amount of water, and a heating device (16) is arranged on the inner side wall of the water tank (15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322630412.0U CN220999647U (en) | 2023-09-27 | 2023-09-27 | Bioreactor with disinfection function for cell fermentation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322630412.0U CN220999647U (en) | 2023-09-27 | 2023-09-27 | Bioreactor with disinfection function for cell fermentation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220999647U true CN220999647U (en) | 2024-05-24 |
Family
ID=91122183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322630412.0U Active CN220999647U (en) | 2023-09-27 | 2023-09-27 | Bioreactor with disinfection function for cell fermentation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220999647U (en) |
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2023
- 2023-09-27 CN CN202322630412.0U patent/CN220999647U/en active Active
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