CN220795029U - Novel carbon 13 isotope analysis device - Google Patents
Novel carbon 13 isotope analysis device Download PDFInfo
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- CN220795029U CN220795029U CN202321814390.7U CN202321814390U CN220795029U CN 220795029 U CN220795029 U CN 220795029U CN 202321814390 U CN202321814390 U CN 202321814390U CN 220795029 U CN220795029 U CN 220795029U
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- light source
- novel carbon
- detector
- isotope analysis
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- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 title claims abstract description 22
- 238000004458 analytical method Methods 0.000 title claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000001179 sorption measurement Methods 0.000 claims description 7
- 230000005855 radiation Effects 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 9
- 238000001914 filtration Methods 0.000 abstract description 6
- 239000002253 acid Substances 0.000 abstract description 4
- 150000007513 acids Chemical class 0.000 abstract description 2
- 239000003570 air Substances 0.000 description 101
- 241000590002 Helicobacter pylori Species 0.000 description 5
- 229940037467 helicobacter pylori Drugs 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000005086 pumping Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- 210000001156 gastric mucosa Anatomy 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000001745 non-dispersive infrared spectroscopy Methods 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000012855 volatile organic compound Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010056663 Gastric infection Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010019375 Helicobacter infections Diseases 0.000 description 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 1
- XSQUKJJJFZCRTK-NJFSPNSNSA-N UREA C 14 Chemical compound N[14C](N)=O XSQUKJJJFZCRTK-NJFSPNSNSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 229950000184 urea c 14 Drugs 0.000 description 1
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- Investigating Or Analysing Materials By Optical Means (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model belongs to the technical field of medical instruments, and discloses a novel carbon 13 isotope analysis device which comprises a light source assembly, an air chamber, a detector assembly, a pipeline and a filtering component communicated with the pipeline, wherein a plurality of air valves are arranged on the pipeline, the filtering component comprises a sponge container, a water-containing sponge, an air inlet pipe and an air outlet pipe, one end of the air inlet pipe is communicated with the pipeline, the other end of the air inlet pipe extends into the sponge container, one end of the air outlet pipe is communicated with the pipeline, and the other end of the air outlet pipe extends into the sponge container; the water-containing sponge can be used for dissolving alcohol such as alcohol and volatile organic matters of acids which are easy to dissolve in water, so that the volatile organic matters in expiration are filtered, and the possibility of false positive conditions of the instrument is effectively reduced.
Description
Technical Field
The utility model relates to the technical field of medical equipment, in particular to a novel carbon 13 isotope analysis device.
Background
Helicobacter pylori (h.pyri) is a unique bacterium that can persist colonizing human gastric mucosa and can cause gastric infections. Helicobacter pylori is the only microorganism species currently known to survive in the human stomach, often parasitic to and beneath the gastric mucosa, and the resulting multiple pathogenic agents damage the gastric mucosa. Infection of helicobacter pylori may be associated with the occurrence of gastritis, gastric ulcer, gastric cancer, gastric mucosa-associated lymphoma, idiopathic thrombocytopenic purpura, and the like. Carbon 13, carbon 14 urea breath test detection systems have been recognized as an effective method for detecting helicobacter pylori, with a full course of diagnosis of about half an hour being an internationally recognized "gold standard" for helicobacter pylori detection. The examinee needs to empty stomach for three hours before checking, take a capsule by warm boiled water completely, blow to the special exhalation bag to leave the sample after sitting still for half an hour, insert the exhalation bag before taking medicine and after taking medicine into the special carbon 13 exhalation tester, can sensitively, accurately, comprehensively detect whether there is helicobacter pylori infection of the patient.
Currently, a special carbon 13 expiration tester on the market adopts a Non-dispersive infrared technology (NDIR, non-Dispersive InfraRed), and the NDIR is a method based on the Billabo gas absorption theory. After the infrared radiation emitted by the infrared light source is absorbed by the gas to be detected with a certain concentration, the spectral intensity in direct proportion to the gas concentration can be changed, so that the concentration of the gas to be detected can be inverted by solving the change quantity of the spectral intensity. By two channels, the breath sample can be measured 13 CO 2 And 12 CO 2 to obtain the concentration of the breath sample 13 C abundance value.
However, since the sterilization operation is often performed using a liquid containing volatile organic compounds such as alcohol in a hospital environment, the instrument is prone to false positive. In addition, a small number of patients may have had drinking or a person sprayed with perfume the day before testing, which may lead to false positives in the device.
Disclosure of Invention
In view of this, it is an object of the present utility model to provide a novel carbon 13 isotope analysis apparatus aimed at reducing the possibility of false positive conditions in the instrument.
In order to achieve the technical purpose, the utility model provides a novel carbon 13 isotope analysis device which comprises a light source assembly, an air chamber, a detector assembly, a pipeline and a filtering component communicated with the pipeline, wherein a plurality of air valves are arranged on the pipeline, the filtering component comprises a sponge container, water-containing sponge, an air inlet pipe and an air outlet pipe, one end of the air inlet pipe is communicated with the pipeline, the other end of the air inlet pipe stretches into the sponge container, one end of the air outlet pipe is communicated with the pipeline, and the other end of the air outlet pipe stretches into the sponge container.
The utility model is further provided with: the light source component is a heat radiation light source component.
The utility model is further provided with: the detector assembly is an infrared detector component.
The utility model is further provided with: also comprises a filter component, a chopping board, a fixed air chamber and CO 2 Adsorption chamber and cylinder, wherein the CO 2 The adsorption chamber and the cylinder are in communication with the conduit.
The utility model is further provided with: the air valves comprise an air valve K1, an air valve K2 and an air valve K3 and … … air valve K17, wherein the air valves K5 to K10 are sample air valves, and the air valves K11 to K16 are background air valves.
The utility model is further provided with: the air chamber comprises 13 CO 2 Air chamber 12 CO 2 An air chamber.
The utility model is further provided with: the light source assembly comprises a light source L1 and a light source L2, the detector assembly comprises a detector T1 and a detector T2, and the filter assembly comprises a filter F1 and a filter F2.
The utility model is further provided with: the light source L1 is arranged on the 13 CO 2 One end of the air chamber, the filter F1 and the detector T1 are arranged on the 13 CO 2 The other end of the air chamber。
The utility model is further provided with: the light source L2 is arranged on the 12 CO 2 One side of the air chamber, the filter F2 and the detector T2 are arranged on the 12 CO 2 The other side of the air chamber.
The utility model is further provided with: the fixed air chamber is arranged on the 12 CO 2 Between the air chamber and the filter F2.
In summary, compared with the prior art, the utility model provides a novel carbon 13 isotope analysis device, which can dissolve alcohol such as alcohol and volatile organic matters of which acids are easily soluble in water by utilizing the water-containing sponge, so as to filter the volatile organic matters in expiration, and effectively reduce the possibility of false positive conditions of an instrument.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural diagram of a novel carbon 13 isotope analysis device according to the present embodiment.
Reference numerals: 100. a wave plate; 200. fixing the air chamber; 300. a pipe; 400. CO 2 An adsorption chamber; 500. a filter member; 501. a sponge container; 502. an aqueous sponge; 503. an air inlet pipe; 504. an air outlet pipe; 600. a cylinder; 700. 13 CO 2 a gas chamber; 800. 12 CO 2 an air chamber.
Detailed Description
For the purpose of making apparent the objects, technical solutions and advantages of the present utility model, the present utility model will be further described in detail with reference to the accompanying drawings and examples, it being understood that the specific examples described herein are for illustration only and are not intended to limit the present utility model.
In the description of the present utility model, it should be noted that the terms "front", "rear", "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate an azimuth or a positional relationship based on that shown in the drawings, only for convenience of description and simplification of the description, and do not indicate or imply that the apparatus or element to be referred to must have a specific azimuth, be constructed and operated in a specific azimuth, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; the two components can be directly connected or indirectly connected through an intermediate medium, or can be communicated inside the two components, or can be connected wirelessly or in a wired way. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
In addition, the technical features described above in the different embodiments of the present utility model may be combined with each other as long as they do not collide with each other.
A novel carbon 13 isotope analysis device, as shown in figure 1, comprises a light source assembly, a detector assembly, a filter assembly, a chopper 100, a fixed air chamber 200, a pipeline 300 and CO communicated through the pipeline 300 2 Adsorption chamber 400, filter member 500, cylinder 600, 13 CO 2 Air chamber 700 12 CO 2 The air chamber 800, the pipeline 300 is provided with a plurality of air valves, the filtering component 500 comprises a sponge container 501, a water-containing sponge 502, an air inlet pipe 503 and an air outlet pipe 504, one end of the air inlet pipe 503 is communicated with the pipeline 300, and the other end of the air inlet pipe 503 extends into the spongeIn the container 501, one end of the air outlet pipe 504 is communicated with the pipeline 300, and the other end of the air outlet pipe 504 extends into the sponge container 501.
In this embodiment, the air valves on the pipeline include air valve K1, air valve K2, air valve K3 … … and air valve K17, which total 17.
In this embodiment, the air valves K5 to K10 are sample air valves.
In the specific implementation process, the air valves K5, K6, K7, K8, K9 and K10 are used to control the opening or closing of the sample bags 1, 2, 3, 4, 5 and 6, respectively, as shown in fig. 1.
In this embodiment, the valves K11 to K16 are background valves.
In a specific implementation process, the air valves K11, K12, K13, K14, K15 and K16 are used to control the opening or closing of the background bags 1, 2, 3, 4, 5 and 6, respectively, as shown in fig. 1.
In the present embodiment, the fixed plenum 200 is CO-free 2 The fixed air chamber, the light source component is a thermal radiation light source component, and the detector component is an infrared detector component.
In some embodiments, the filter assembly, the chopper 100, the cylinder 600, and the like may not be provided when the detection is performed by the laser light source.
In the specific implementation process, alcohol such as alcohol and acid can be dissolved in volatile organic matters which are easy to dissolve in water by utilizing the water-containing sponge 502, so that the volatile organic matters in expiration are filtered, and the possibility of false positive conditions of the instrument is effectively reduced.
In some embodiments, the liquid in the sponge may be other liquids capable of filtering alcohol such as alcohol and acid volatile organic compounds according to practical situations, which is not limited herein.
In this embodiment, the light source assembly includes a light source L1 and a light source L2, the detector assembly includes a detector T1 and a detector T2, the filter assembly includes a filter F1 and a filter F2, and the light source L1Is arranged at 13 CO 2 One end of the air chamber, a filter F1 and a detector T1 are arranged on 13 CO 2 The other end of the air chamber is provided with a light source L2 12 CO 2 One side of the air chamber, a filter F2 and a detector T2 are arranged on 12 CO 2 The other side of the air chamber is provided with a fixed air chamber 200 12 CO 2 Between the air cell and the filter F2, as shown in fig. 1.
The working principle or detection flow of this embodiment is:
step 1, opening the gas valve K3 and the gas valve K17, and using the cylinder 600 to pass CO 2 The ambient air in the adsorption chamber 400 is filtered by the aqueous sponge 502 and then is sucked into the cylinder 600;
step 2, closing the air valve K3 and the air valve K17, opening the air valve K2 and the air valve K1, and pumping air into the container 13 CO 2 Air chamber 700 12 CO 2 A gas chamber 800, thereby 13 CO 2 Air chamber 700 12 CO 2 Residual gas in the gas chamber 800 is cleaned;
step 3, repeating the step 1 and the step 2 twice, closing the air valve K2 and the air valve K1, and testing 13 CO 2 Air chamber 700 12 CO 2 Output values of the detector T1 and the detector T2 when the air chamber 800 is not filtered by the water-containing sponge 502 are used as a baseline D1 of the detector k 、D2 k ；
Step 4, opening an air valve K11 and an air valve K17, and pumping the background air 1 filtered by the water-containing sponge 502 into the air cylinder by utilizing the air cylinder 600;
step 5, closing the air valve K11 and the air valve K17, opening the air valve K2 and the air valve K1, and pumping air 13 CO 2 Air chamber 700 12 CO 2 A gas chamber 800, thereby 13 CO 2 Air chamber 12 CO 2 Flushing out residual gas in the gas chamber;
step 6, repeating the step 4 and the step 5 twice, and closing the air valve K2 and the air valve K1; testing 13 CO 2 Air chamber 700 12 CO 2 The output value D1 of the detector T1 and the detector T2 when the air chamber 800 is filled with the bottom air 1 b 、D2 b ；
Step 7, opening the air valve K5 and the air valve K17, and pumping the sample gas 1 filtered by the water-containing sponge 502 into the air cylinder 600 by using the air cylinder 600;
step 8, closing the air valve K5 and the air valve K17, opening the air valve K2 and the air valve K1, and pumping air into the air tank 13 CO 2 Air chamber 700 12 CO 2 A gas chamber 800, thereby 13 CO 2 Air chamber 700 12 CO 2 Residual gas in the gas chamber 800 is flushed out;
step 9, repeating the step 7 and the step 8 twice, and closing the air valve K2 and the air valve K1; testing 13 CO 2 Air chamber 700 12 CO 2 Detector T1 and output value D1 of detector T2 when gas cell 800 is filled with sample gas 1 y 、D2 y ；
Step 10, calculating the sample gas 1 and the bottom gas 1 13 C abundance difference:
wherein b is a correction coefficient.
It should be noted that, before the present detector works, all air valves are in a closed state, and fig. 1 only illustrates one connection state of the pipe 300 and each component.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. While still being apparent from variations or modifications that may be made by those skilled in the art are within the scope of the utility model.
Claims (10)
1. A novel carbon 13 isotope analysis device, characterized in that: including light source subassembly, air chamber, detector subassembly, pipeline and pass through the filter element of pipeline intercommunication, install a plurality of pneumatic valves on the pipeline, filter element includes sponge container, water-containing sponge, intake pipe and outlet duct, the one end of intake pipe with the pipeline intercommunication, the other end of intake pipe stretches into in the sponge container, the one end of outlet duct with the pipeline intercommunication, the other end of outlet duct stretches into in the sponge container.
2. The novel carbon 13 isotope analysis apparatus of claim 1 wherein the light source assembly is a thermal radiation light source component.
3. The novel carbon 13 isotope analysis apparatus of claim 2 wherein the detector assembly is an infrared detector assembly.
4. A novel carbon 13 isotope analysis apparatus in accordance with any one of claims 1 to 3, further comprising a filter assembly, a chopper, a fixed gas chamber, CO 2 Adsorption chamber and cylinder, wherein the CO 2 The adsorption chamber and the cylinder are in communication with the conduit.
5. The novel carbon 13 isotope analysis device according to claim 4, wherein the plurality of gas valves comprises a gas valve K1, a gas valve K2, a gas valve K3 … …, and a gas valve K17, wherein the gas valve K5 to the gas valve K10 are sample gas valves, and the gas valve K11 to the gas valve K16 are background gas valves.
6. The novel carbon 13 isotope analysis apparatus of claim 4 wherein the gas chamber comprises 13 CO 2 Air chamber 12 CO 2 An air chamber.
7. The novel carbon 13 isotope analysis device according to claim 6 wherein the light source assembly includes a light source L1 and a light source L2, the detector assembly includes a detector T1 and a detector T2, and the filter assembly includes a filter F1 and a filter F2.
8. The novel carbon 13 isotope analysis apparatus according to claim 7, characterized in thatCharacterized in that the light source L1 is arranged on the 13 CO 2 One end of the air chamber, the filter F1 and the detector T1 are arranged on the 13 CO 2 The other end of the air chamber.
9. The novel carbon 13 isotope analysis apparatus according to claim 7, wherein the light source L2 is provided in the apparatus 12 CO 2 One side of the air chamber, the filter F2 and the detector T2 are arranged on the 12 CO 2 The other side of the air chamber.
10. The novel carbon 13 isotope analysis apparatus according to any one of claims 7 to 9, wherein the stationary gas chamber is provided in the reactor 12 CO 2 Between the air chamber and the filter F2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321814390.7U CN220795029U (en) | 2023-07-11 | 2023-07-11 | Novel carbon 13 isotope analysis device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321814390.7U CN220795029U (en) | 2023-07-11 | 2023-07-11 | Novel carbon 13 isotope analysis device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220795029U true CN220795029U (en) | 2024-04-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321814390.7U Active CN220795029U (en) | 2023-07-11 | 2023-07-11 | Novel carbon 13 isotope analysis device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220795029U (en) |
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2023
- 2023-07-11 CN CN202321814390.7U patent/CN220795029U/en active Active
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