CN114354829A - Human intestinal disease detection device for detecting methane hydrogen expiration - Google Patents
Human intestinal disease detection device for detecting methane hydrogen expiration Download PDFInfo
- Publication number
- CN114354829A CN114354829A CN202111553683.XA CN202111553683A CN114354829A CN 114354829 A CN114354829 A CN 114354829A CN 202111553683 A CN202111553683 A CN 202111553683A CN 114354829 A CN114354829 A CN 114354829A
- Authority
- CN
- China
- Prior art keywords
- way electromagnetic
- electromagnetic valve
- sample
- gas
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Images
Abstract
The invention discloses a human intestinal disease detection device, which comprises a detection air chamber, a chromatographic column, a filter bottle, a carrier gas air pump, a first flow valve, a first flowmeter, a drying pipe, a metering ring, a second flowmeter, a second flow valve, a sample outlet air pump and first to third three-way electromagnetic valves, wherein the detection air chamber is provided with a gas inlet and a gas outlet; the human intestinal disease detection device has the advantages of high detection performance, no wound, convenience and the like, and can be used for large-scale data acquisition and diagnosis analysis of clinical and family patients.
Description
Technical Field
The invention belongs to the field of medical equipment, and discloses a human intestinal disease detection device for detecting methane hydrogen expiration.
Background
At present, the hydrogen component in the respiratory gas is widely concerned at home and abroad for diagnosing gastrointestinal diseases and early diagnosing necrotic enteritis of newborns with higher lethality and detecting the overgrowth of small intestinal bacteria of irritable bowel syndrome patients. Hydrogen and methane respiratory gases can also be used to diagnose certain complex proteolytic enzyme deficiencies. In the laboratory chromatographic analysis generally adopted at the present stage, a detection system which adopts a special gas chromatograph and utilizes a manual injector to sample, double-column parallel connection, split-flow sample injection and double detectors to detect simultaneously is adopted, but the special gas chromatograph has overlarge volume, so that the application of respiration detection is limited.
Disclosure of Invention
The invention aims to provide a human intestinal disease detection device for detecting methane hydrogen exhaled breath, aiming at the defects of the prior art, the monitoring device can automatically detect the methane hydrogen concentration value of the exhaled breath of the intestinal tract and compare the difference of the concentration values of healthy people, thereby realizing the exhaled breath detection function.
The human intestinal disease detection device comprises a detection air chamber, a chromatographic column, a filter bottle, a carrier gas air pump, a first flow valve, a first flow meter, a drying tube, a metering ring, a second flow meter, a second flow valve and a sample outlet air pump; the inlet of the filter bottle is connected with external air, and the outlet of the filter bottle is connected with a first port of a first three-way electromagnetic valve and a first port of a third three-way electromagnetic valve through a carrier gas air pump, a first flow valve and a first flow meter; the inlet of the detection air chamber is connected with the second port of the first three-way electromagnetic valve, and the outlet of the detection air chamber is used as the outlet of the gas; the inlet of the drying tube is used as a sample inlet, and the outlet of the drying tube is connected with a first port of the second three-way electromagnetic valve; one end of the metering ring is connected with the second port of the second three-way electromagnetic valve, and the other end of the metering ring is connected with the second port of the third three-way electromagnetic valve; the third port of the first three-way electromagnetic valve is connected with the third port of the second three-way electromagnetic valve; a third port of the third three-way electromagnetic valve is connected with an inlet of the sample gas pump through a second flowmeter and a second flow valve; an outlet of the sample outlet air pump is used as a sample outlet;
a sample inlet pipeline, a sample outlet pipeline and a gas sensor detection module are arranged in the detection gas chamber; the gas sensor detection module comprises a CO2 sensor and a methane hydrogen sensor; a CO2 sensor is arranged in the sample injection pipeline, and the outlet of the CO2 sensor is communicated with the sample injection port of the chromatographic column of the external equipment; a methane hydrogen sensor is arranged in the sample outlet pipeline, and the inlet of the methane hydrogen sensor is communicated with the sample outlet of the chromatographic column of the external equipment;
when the drying tube is communicated with the metering ring through the second three-way electromagnetic valve and the second flowmeter is communicated with the metering ring through the third three-way electromagnetic valve, the drying tube, the metering ring, the second flowmeter valve and the sample outlet air pump are sequentially communicated to form a sample feeding passage.
When the detection air chamber is communicated with the metering ring through a first three-way electromagnetic valve and a second three-way electromagnetic valve, and the first flowmeter is communicated with the metering ring through a third three-way electromagnetic valve, the detection air chamber, the chromatographic column, the filter flask, the carrier gas air pump, the first flow valve, the first flowmeter, the drying tube, the metering ring, the second flowmeter, the second flow valve and the sample outlet air pump form a detection passage; before the sample is pushed into the chromatographic column, the concentration of carbon dioxide is detected by a CO2 sensor, each group of gas separated by the chromatographic column is pushed into the detection gas chamber again, and then the concentration of methane and hydrogen is detected by a methane-hydrogen sensor.
When the first flowmeter and the detection air chamber are communicated through the first three-way electromagnetic valve, the filter flask, the carrier gas air pump, the first flow valve, the first flowmeter, the detection air chamber and the chromatographic column are communicated in sequence to form a cleaning circuit.
Preferably, the drying tube is filled with silica gel particles for filtering moisture in the exhaled air so as to eliminate errors of humidity on the response of the sensor.
Preferably, the metering ring is used for quantitatively storing the sample gas.
Preferably, the first and second flow meters are used for detecting the gas flow; the first and second flow valves are used for regulating the gas flow.
Preferably, the carrier gas pump provides a negative pressure to draw the sample gas in the gas bag.
Preferably, the filter bottle is filled with activated carbon, silica gel particles and molecular sieves, and is used for filtering impurity molecules in indoor air to obtain clean air as a carrier gas so as to continuously clean the chromatographic column and the air chamber.
The invention has the beneficial effects that:
the human intestinal disease detection device has the advantages of high detection performance, no wound, convenience and the like, and can be used for large-scale data acquisition and diagnosis analysis of clinical and family patients.
The invention provides a human intestinal disease detection device for detecting methane-hydrogen expiration, which selects hydrogen and methane as markers, designs a human gastrointestinal disease expiration detection device, can quickly detect the volume fraction of hydrogen and the volume fraction of methane in expiration, and corrects a detection result according to the volume fraction of carbon dioxide so as to eliminate the influence of objective factors on stomach gas.
The human intestinal disease detection device is based on a gas chromatography device, and the complex structure of large-scale gas chromatography device equipment is simplified.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic cross-sectional view of the detection chamber according to the present invention.
Detailed Description
The present invention is further analyzed with reference to the following specific examples.
As shown in fig. 1, the human intestinal disease detection device comprises a detection air chamber, a chromatographic column, a filter bottle, a carrier gas air pump, a first flow valve, a first flowmeter, a drying tube, a metering ring, a second flowmeter, a sample outlet air pump and first to third three-way electromagnetic valves; the inlet of the filter bottle is connected with external air, and the outlet of the filter bottle is connected with a first port of a first three-way electromagnetic valve and a first port of a third three-way electromagnetic valve through a carrier gas air pump, a first flow valve and a first flow meter; the inlet of the detection air chamber is connected with the second port of the first three-way electromagnetic valve, and the outlet of the detection air chamber is used as the outlet of the gas; the inlet of the drying tube is used as a sample inlet, and the outlet of the drying tube is connected with a first port of the second three-way electromagnetic valve; one end of the metering ring is connected with the second port of the second three-way electromagnetic valve, and the other end of the metering ring is connected with the second port of the third three-way electromagnetic valve; the third port of the first three-way electromagnetic valve is connected with the third port of the second three-way electromagnetic valve; a third port of the third three-way electromagnetic valve is connected with an inlet of the sample gas pump through a second flowmeter and a second flow valve; an outlet of the sample outlet air pump is used as a sample outlet;
as shown in fig. 2, a sample inlet pipeline, a sample outlet pipeline and a gas sensor detection module are arranged in the detection gas chamber; the gas sensor detection module comprises a CO2 sensor and a methane hydrogen sensor; a CO2 sensor is arranged in the sample injection pipeline, and the outlet of the CO2 sensor is communicated with the sample injection port of the chromatographic column of the external equipment; a methane hydrogen sensor is arranged in the sample outlet pipeline, and the inlet of the methane hydrogen sensor is communicated with the sample outlet of the chromatographic column of the external equipment;
when the drying tube is communicated with the metering ring through the second three-way electromagnetic valve and the second flowmeter is communicated with the metering ring through the third three-way electromagnetic valve, the drying tube, the metering ring, the second flowmeter valve and the sample outlet air pump are sequentially communicated to form a sample feeding passage.
When the detection air chamber is communicated with the metering ring through the first three-way electromagnetic valve and the second three-way electromagnetic valve, and the first flowmeter is communicated with the metering ring through the third three-way electromagnetic valve, the detection air chamber, the chromatographic column, the filter bottle, the carrier gas air pump, the first flow valve, the first flowmeter, the drying pipe, the metering ring, the second flowmeter, the second flow valve and the sample outlet air pump form a detection passage, a sample (namely gas exhaled by a human body) enters the metering ring through the drying pipe and the second three-way electromagnetic valve, air serving as carrier gas enters the metering ring through the filter bottle, the carrier gas air pump, the first flow valve, the first flowmeter and the third three-way electromagnetic valve, and the sample in the metering ring is pushed into the chromatographic column by the carrier gas through the second three-way electromagnetic valve, the first three-way electromagnetic valve and the detection air chamber; before the sample is pushed into the chromatographic column, the concentration of carbon dioxide is detected by a CO2 sensor, each group of gas separated by the chromatographic column is pushed into the detection gas chamber again, and then the concentration of methane and hydrogen is detected by a methane-hydrogen sensor.
When the first flowmeter and the detection air chamber are communicated through the first three-way electromagnetic valve, the filter flask, the carrier gas air pump, the first flow valve, the first flowmeter, the detection air chamber and the chromatographic column are communicated in sequence to form a cleaning circuit. And after the responses of the CO2 sensor and the methane hydrogen sensor are recovered to the baseline value, carrying out next sample injection and detection.
The main control system controls the working states of the first three-way electromagnetic valves, can receive data detected by the CO2 sensor and the methane hydrogen sensor, and then displays the detection result on a display liquid crystal screen after analyzing and processing the data.
The above embodiments are not intended to limit the present invention, and the present invention is not limited to the above embodiments, and all embodiments are within the scope of the present invention as long as the requirements of the present invention are met.
Claims (6)
1. The human intestinal disease detection device is characterized by comprising a detection air chamber, a chromatographic column, a filter bottle, a carrier gas air pump, a first flow valve, a first flowmeter, a drying tube, a metering ring, a second flowmeter, a second flow valve and a sample outlet air pump; the inlet of the filter bottle is connected with external air, and the outlet of the filter bottle is connected with a first port of a first three-way electromagnetic valve and a first port of a third three-way electromagnetic valve through a carrier gas air pump, a first flow valve and a first flow meter; the inlet of the detection air chamber is connected with the second port of the first three-way electromagnetic valve, and the outlet of the detection air chamber is used as the outlet of the gas; the inlet of the drying tube is used as a sample inlet, and the outlet of the drying tube is connected with a first port of the second three-way electromagnetic valve; one end of the metering ring is connected with the second port of the second three-way electromagnetic valve, and the other end of the metering ring is connected with the second port of the third three-way electromagnetic valve; the third port of the first three-way electromagnetic valve is connected with the third port of the second three-way electromagnetic valve; a third port of the third three-way electromagnetic valve is connected with an inlet of the sample gas pump through a second flowmeter and a second flow valve; an outlet of the sample outlet air pump is used as a sample outlet;
a sample inlet pipeline, a sample outlet pipeline and a gas sensor detection module are arranged in the detection gas chamber; the gas sensor detection module comprises a CO2 sensor and a methane hydrogen sensor; a CO2 sensor is arranged in the sample injection pipeline, and the outlet of the CO2 sensor is communicated with the sample injection port of the chromatographic column of the external equipment; a methane hydrogen sensor is arranged in the sample outlet pipeline, and the inlet of the methane hydrogen sensor is communicated with the sample outlet of the chromatographic column of the external equipment;
when the drying pipe is communicated with the metering ring through the second three-way electromagnetic valve and the second flowmeter is communicated with the metering ring through the third three-way electromagnetic valve, the drying pipe, the metering ring, the second flowmeter, the second flow valve and the sample outlet air pump are communicated in sequence to form a sample inlet passage;
when the detection air chamber is communicated with the metering ring through a first three-way electromagnetic valve and a second three-way electromagnetic valve, and the first flowmeter is communicated with the metering ring through a third three-way electromagnetic valve, the detection air chamber, the chromatographic column, the filter flask, the carrier gas air pump, the first flow valve, the first flowmeter, the drying tube, the metering ring, the second flowmeter, the second flow valve and the sample outlet air pump form a detection passage; before the sample is pushed into the chromatographic column, the concentration of carbon dioxide is detected by a CO2 sensor, each group of gas separated by the chromatographic column is pushed into a detection gas chamber again, and then the concentration of methane and hydrogen is detected by a methane-hydrogen sensor;
when the first flowmeter and the detection air chamber are communicated through the first three-way electromagnetic valve, the filter flask, the carrier gas air pump, the first flow valve, the first flowmeter, the detection air chamber and the chromatographic column are communicated in sequence to form a cleaning circuit.
2. The device for detecting intestinal diseases of human body according to claim 1, wherein said drying tube is filled with silica gel particles.
3. The device according to claim 1, wherein the metering ring is adapted to quantitatively store the sample gas.
4. The human intestinal disease detecting device of claim 1, wherein the first and second flow meters are for detecting a flow of gas; the first and second flow valves are used for regulating the gas flow.
5. The human intestinal disease detection device of claim 1, wherein the carrier gas pump provides negative pressure to pump the sample gas from the gas bag.
6. The human intestinal disease detection device of claim 1, wherein the filter bottle contains activated carbon, silica gel particles, molecular sieve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111553683.XA CN114354829A (en) | 2021-12-17 | 2021-12-17 | Human intestinal disease detection device for detecting methane hydrogen expiration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111553683.XA CN114354829A (en) | 2021-12-17 | 2021-12-17 | Human intestinal disease detection device for detecting methane hydrogen expiration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114354829A true CN114354829A (en) | 2022-04-15 |
Family
ID=81099425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111553683.XA Withdrawn CN114354829A (en) | 2021-12-17 | 2021-12-17 | Human intestinal disease detection device for detecting methane hydrogen expiration |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114354829A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210096111A1 (en) * | 2017-05-15 | 2021-04-01 | The Regents Of The University Of Michigan | Progressive Cellular Architecture For Microfabricated Gas Chromatograph |
| CN115324176A (en) * | 2022-07-27 | 2022-11-11 | 浙江大学台州研究院 | Intelligent closestool for monitoring health of small intestine |
-
2021
- 2021-12-17 CN CN202111553683.XA patent/CN114354829A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210096111A1 (en) * | 2017-05-15 | 2021-04-01 | The Regents Of The University Of Michigan | Progressive Cellular Architecture For Microfabricated Gas Chromatograph |
| US11927574B2 (en) * | 2017-05-15 | 2024-03-12 | The Regents Of The University Of Michigan | Progressive cellular architecture for microfabricated gas chromatograph |
| CN115324176A (en) * | 2022-07-27 | 2022-11-11 | 浙江大学台州研究院 | Intelligent closestool for monitoring health of small intestine |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114354829A (en) | Human intestinal disease detection device for detecting methane hydrogen expiration | |
| EP3448256B1 (en) | Systems and device for capturing breath samples | |
| CN101368921B (en) | High sensitivity and high-selective gas transducer | |
| CN109938736B (en) | Portable expired air collecting device and method | |
| CN105388274A (en) | Measuring apparatus for concentrations of nitric oxide and carbon monoxide in expired air | |
| CN205263092U (en) | Measurement device for expiration nitric oxide and carbon monoxide concentration | |
| CN110123382B (en) | Human body exhaled gas off-line acquisition device and method | |
| CN110146651A (en) | Expiratory air detection system based on gas sensor | |
| CN115711864A (en) | Exhaled gas gastrointestinal tract disease determination system and method | |
| CN108627619A (en) | A kind of portable electric nose quickly detected for animalsderived feedstuffs freshness | |
| CN114200087A (en) | Expiration tester and using method thereof | |
| CN105758958A (en) | Quick detector for hydrogen and methane components in respiratory air | |
| CN202404092U (en) | Human body respiration performance parameter detector | |
| CN219183832U (en) | Expired air collection system | |
| CN207601028U (en) | A kind of simple gas-chromatography gas circuit | |
| Gao et al. | Simultaneous detection of hydrogen and methane in breath for the diagnosis of small intestinal bacterial overgrowth by fast gas chromatography | |
| CN110554028A (en) | Gas detection method and gas detection system based on same | |
| CN207036849U (en) | A kind of medical breath sample detection means | |
| CN220690866U (en) | Expired gas multicomponent detecting instrument | |
| CN215985890U (en) | Methane and hydrogen exhaled gas detection device capable of controlling stable output of airflow | |
| CN106501430A (en) | The detection method of the volatile organic matter related to pulmonary carcinoma in a kind of respiratory gass | |
| CN208506007U (en) | A kind of portable electric nose quickly detected for animalsderived feedstuffs freshness | |
| CN101797463B (en) | Gas sampling enrichment device based on nano-fibers and enrichment method thereof | |
| CN205484226U (en) | A device for diagnosing human helicobacter pylori infects | |
| CN113686790A (en) | Expired gas detection system and method for lung cancer screening |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20220415 |
|
| WW01 | Invention patent application withdrawn after publication |