CN220795030U - Carbon 13 isotope analyzer - Google Patents
Carbon 13 isotope analyzer Download PDFInfo
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- CN220795030U CN220795030U CN202321814385.6U CN202321814385U CN220795030U CN 220795030 U CN220795030 U CN 220795030U CN 202321814385 U CN202321814385 U CN 202321814385U CN 220795030 U CN220795030 U CN 220795030U
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- air
- chamber
- carbon
- isotope analyzer
- condensing
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- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 title claims abstract description 22
- 238000009833 condensation Methods 0.000 claims description 12
- 230000005494 condensation Effects 0.000 claims description 12
- 238000001179 sorption measurement Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 210000003437 trachea Anatomy 0.000 claims 5
- 238000005057 refrigeration Methods 0.000 claims 3
- 239000007789 gas Substances 0.000 abstract description 30
- 239000007788 liquid Substances 0.000 abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 4
- 239000004065 semiconductor Substances 0.000 abstract description 3
- 239000003570 air Substances 0.000 description 115
- 230000017525 heat dissipation Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 241000590002 Helicobacter pylori Species 0.000 description 5
- 229940037467 helicobacter pylori Drugs 0.000 description 5
- 238000005086 pumping Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- 210000001156 gastric mucosa Anatomy 0.000 description 4
- 239000003814 drug Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000001745 non-dispersive infrared spectroscopy Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010056663 Gastric infection Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010019375 Helicobacter infections Diseases 0.000 description 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 1
- XSQUKJJJFZCRTK-NJFSPNSNSA-N UREA C 14 Chemical compound N[14C](N)=O XSQUKJJJFZCRTK-NJFSPNSNSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 229950000184 urea c 14 Drugs 0.000 description 1
- 239000012855 volatile organic compound Substances 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Landscapes
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The utility model belongs to the technical field of medical instruments, and discloses a carbon 13 isotope analyzer which comprises a light source assembly, an air chamber, a detector assembly, an air pipe and a condensing device communicated with the air pipe, wherein a plurality of air valves are arranged on the air pipe, the condensing device comprises a condensing chamber, a refrigerating sheet, a heat radiating part, a condensate box, an air inlet pipe and an air outlet pipe, one end of the air inlet pipe is communicated with the air pipe, the other end of the air inlet pipe stretches into the condensing chamber, one end of the air outlet pipe is communicated with the air pipe, the other end of the air outlet pipe stretches into the condensing chamber, the refrigerating sheet is arranged outside the condensing chamber, and the heat radiating part is arranged on one side of the refrigerating sheet, which is far away from the condensing chamber; according to the utility model, through the arrangement of the semiconductor refrigerating sheet and other parts, organic gases such as alcohol in expiration can be condensed into liquid drops, so that volatile organic matters in expiration are filtered, and the possibility of false positive of the instrument is effectively reduced.
Description
Technical Field
The utility model relates to the technical field of medical instruments, in particular to a carbon 13 isotope analyzer.
Background
Helicobacter pylori (h.pyri) is a unique bacterium that can persist colonizing human gastric mucosa and can cause gastric infections. Helicobacter pylori is the only microorganism species currently known to survive in the human stomach, often parasitic to and beneath the gastric mucosa, and the resulting multiple pathogenic agents damage the gastric mucosa. Infection of helicobacter pylori may be associated with the occurrence of gastritis, gastric ulcer, gastric cancer, gastric mucosa-associated lymphoma, idiopathic thrombocytopenic purpura, and the like. Carbon 13, carbon 14 urea breath test detection systems have been recognized as an effective method for detecting helicobacter pylori, with a full course of diagnosis of about half an hour being an internationally recognized "gold standard" for helicobacter pylori detection. The examinee needs to empty stomach for three hours before checking, take a capsule by warm boiled water completely, blow to the special exhalation bag to leave the sample after sitting still for half an hour, insert the exhalation bag before taking medicine and after taking medicine into the special carbon 13 exhalation tester, can sensitively, accurately, comprehensively detect whether there is helicobacter pylori infection of the patient.
Currently, a special carbon 13 expiration tester on the market adopts a Non-dispersive infrared technology (NDIR, non-Dispersive InfraRed), and the NDIR is a method based on the Billabo gas absorption theory. After the infrared radiation emitted by the infrared light source is absorbed by the gas to be detected with a certain concentration, the spectral intensity in direct proportion to the gas concentration can be changed, so that the concentration of the gas to be detected can be inverted by solving the change quantity of the spectral intensity. By two channels, the breath sample can be measured 13 CO 2 And 12 CO 2 to obtain the concentration of the breath sample 13 C abundance value.
However, since the sterilization operation is often performed using a liquid containing volatile organic compounds such as alcohol in a hospital environment, the instrument is prone to false positive. In addition, a small number of patients may have had drinking or a person sprayed with perfume the day before testing, which may lead to false positives in the device.
Disclosure of Invention
In view of this, it is an object of the present utility model to provide a carbon 13 isotope analyzer that aims to reduce the likelihood of false positive conditions in the instrument.
In order to achieve the technical purpose, the utility model provides a carbon 13 isotope analyzer which comprises a light source component, an air chamber, a detector component, an air pipe and a condensing device communicated with the air pipe, wherein a plurality of air valves are arranged on the air pipe, the condensing device comprises a condensing chamber, a refrigerating piece, a radiating component, a condensate box, an air inlet pipe and an air outlet pipe, one end of the air inlet pipe is communicated with the air pipe, the other end of the air inlet pipe stretches into the condensing chamber, one end of the air outlet pipe is communicated with the air pipe, the other end of the air outlet pipe stretches into the condensing chamber, the refrigerating piece is arranged outside the condensing chamber, and the radiating component is arranged on one side, far away from the condensing chamber, of the refrigerating piece.
The utility model is further provided with: the condensate box can be detachably arranged on one side of the condensing chamber, and the condensate box is communicated with the condensing chamber.
The utility model is further provided with: the interior of the condensing chamber is arranged in a comb-shaped structure.
The utility model is further provided with: the heat radiating component is any one of a radiating fin and a cold water drum, or is any one combination of the radiating fin and a fan, and the cold water drum and the fan.
The utility model is further provided with: also comprises a filter component, a chopping board, a fixed air chamber and CO 2 Adsorption chamber and cylinder, wherein the CO 2 The adsorption chamber and the air cylinder are communicated with the air pipe, and the air valves comprise an air valve K1, an air valve K2 and an air valve K3 … … air valve K17, wherein the air valves K5 to K10 are sample air valves, and the air valves K11 to K16 are background air valves.
The utility model is further provided with: the air chamber comprises 13 CO 2 Air chamber 12 CO 2 An air chamber.
The utility model is further provided with: the light source assembly comprises a light source L1 and a light source L2, the detector assembly comprises a detector T1 and a detector T2, and the filter assembly comprises a filter F1 and a filter F2.
The utility model is further provided with: the light source L1 is arranged on the 13 CO 2 One end of the air chamber, the filter F1 and the detector T1 are arranged on the 13 CO 2 The other end of the air chamber.
The utility model is further provided with: the light source L2 is arranged on the 12 CO 2 One side of the air chamber, the filter F2 and the detector T2 are arranged on the 12 CO 2 The other side of the air chamber.
The utility model is further provided with: the fixed air chamber is arranged on the 12 CO 2 Between the air chamber and the filter F2.
In summary, compared with the prior art, the utility model provides the carbon 13 isotope analyzer, which can condense organic gases such as alcohol in expiration into liquid drops through the arrangement of the semiconductor refrigerating sheet and the like, thereby filtering volatile organic matters in expiration and effectively reducing the possibility of false positive conditions of the instrument.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural diagram of a carbon 13 isotope analyzer according to the present embodiment.
Reference numerals: 100. a wave plate; 200. fixing the air chamber; 300. an air pipe; 400. CO 2 An adsorption chamber; 500. a condensing device; 501. a condensing chamber; 502. a cooling sheet; 503. a heat radiating member; 504. a condensate box; 505. an air inlet pipe; 506. An air outlet pipe; 600. a cylinder; 700. 13 CO 2 a gas chamber; 800. 12 CO 2 an air chamber.
Detailed Description
For the purpose of making apparent the objects, technical solutions and advantages of the present utility model, the present utility model will be further described in detail with reference to the accompanying drawings and examples, it being understood that the specific examples described herein are for illustration only and are not intended to limit the present utility model.
In the description of the present utility model, it should be noted that the terms "front", "rear", "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate an azimuth or a positional relationship based on that shown in the drawings, only for convenience of description and simplification of the description, and do not indicate or imply that the apparatus or element to be referred to must have a specific azimuth, be constructed and operated in a specific azimuth, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; the two components can be directly connected or indirectly connected through an intermediate medium, or can be communicated inside the two components, or can be connected wirelessly or in a wired way. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
In addition, the technical features described above in the different embodiments of the present utility model may be combined with each other as long as they do not collide with each other.
A carbon 13 isotope analyzer, as shown in figure 1, comprises a light source assembly, a detectorDevice assembly, filter assembly, chopper 100, stationary gas cell 200, gas tube 300, and CO communicating through gas tube 300 2 Adsorption chamber 400, condensing unit 500, cylinder 600, 13 CO 2 Air chamber 700 12 CO 2 The air chamber 800 is provided with a plurality of air valves on the air pipe 300, the condensing device 500 comprises a condensing chamber 501, a refrigerating sheet 502, a heat dissipation part 503, a condensate box 504, an air inlet pipe 505 and an air outlet pipe 506, one end of the air inlet pipe 505 is communicated with the air pipe 300, the other end of the air inlet pipe 505 extends into the condensing chamber 501, one end of the air outlet pipe 506 is communicated with the air pipe 300, the other end of the air outlet pipe 506 extends into the condensing chamber 501, the refrigerating sheet 502 is arranged outside the condensing chamber 501, and the heat dissipation part 503 is arranged on one side, far away from the condensing chamber 501, of the refrigerating sheet 502.
In this embodiment, the condensate box 504 is detachably disposed on one side of the condensation chamber 501, the condensate box 504 is communicated with the condensation chamber 501, in a specific implementation process, the condensate box 504 is used for collecting condensed liquid in gas, when the liquid in the condensed liquid reaches a certain amount, the condensate box 504 is removed by pulling out, and the liquid in the condensed liquid is poured into a designated wastewater tank.
In this embodiment, the condensation chamber 501 is disposed in a comb-like structure, and in a specific implementation process, the condensation chamber 501 disposed in a comb-like structure can effectively increase a contact area between the gas and the cold surface, and improve condensation efficiency.
In some embodiments, the interior of the condensation chamber 501 may be configured to have other shapes that can increase the contact area between the gas and the cold surface according to practical situations, which is not limited herein.
In this embodiment, the heat dissipation component 503 is any one of a heat dissipation fin and a cold water drum, or any one combination of a heat dissipation fin and a fan (as shown in fig. 1), a cold water drum and a fan (not shown), and in a specific implementation process, the fan is added, so that the heat dissipation efficiency can be effectively improved.
It should be noted that, in some embodiments, specific components of the heat dissipation device may be selectively disposed according to actual situations, which is not limited herein specifically.
In this embodiment, by setting the components such as the semiconductor refrigerating sheet 502, the organic gas such as alcohol in the expired air can be condensed into droplets, so as to filter the volatile organic matters in the expired air, and effectively reduce the possibility of false positive condition of the instrument.
In this embodiment, the air valves on the air pipe include air valve K1, air valve K2, air valve K3 … … and air valve K17, which total 17.
In this embodiment, the air valves K5 to K10 are sample air valves.
In the specific implementation process, the air valves K5, K6, K7, K8, K9 and K10 are used to control the opening or closing of the sample bags 1, 2, 3, 4, 5 and 6, respectively, as shown in fig. 1.
In this embodiment, the valves K11 to K16 are background valves.
In a specific implementation process, the air valves K11, K12, K13, K14, K15 and K16 are used to control the opening or closing of the background bags 1, 2, 3, 4, 5 and 6, respectively, as shown in fig. 1.
In the present embodiment, the fixed plenum 200 is CO-free 2 The air chamber is fixed, and the light source used by the light source component is a heat radiation light source.
In some embodiments, the filter assembly, the chopper 100, the cylinder 600, and the like may not be provided when the detection is performed by the laser light source.
In this embodiment, the light source assembly includes a light source L1 and a light source L2, the detector assembly includes a detector T1 and a detector T2, the filter assembly includes a filter F1 with a center wavelength of 4412nm and a filter F2 with a center wavelength of 4280nm, and the light source L1 is disposed 13 CO 2 One end of the air chamber 700, a filter F1 and a detector T1 are arranged on 13 CO 2 The other end of the air chamber 700 is provided with a light source L2 12 CO 2 One side of the air chamber 800 is provided with a filter F2 and a detector T2 12 CO 2 The other side of the air chamber 800 is provided with a fixed air chamber 200 12 CO 2 Air cell 800 and filteringBetween the sheets F2 as shown in fig. 1.
The working principle or detection flow of this embodiment is:
step 1, opening the gas valve K3 and the gas valve K17, and using the cylinder 600 to pass CO 2 The ambient air of the adsorption chamber 400 is filtered through the condensing chamber and then is drawn into the cylinder 600;
step 2, closing the air valve K3 and the air valve K17, opening the air valve K2 and the air valve K1, and pumping air into the container 13 CO 2 Air chamber 700 12 CO 2 A gas chamber 800, thereby 13 CO 2 Air chamber 700 12 CO 2 Residual gas in the gas chamber 800 is cleaned;
step 3, repeating the step 1 and the step 2 twice, closing the air valve K2 and the air valve K1, and testing 13 CO 2 Air chamber 700 12 CO 2 Output values of the detector T1 and the detector T2 when the air chamber 800 does not pass through the condensation chamber for filtering are used as a baseline D1 of the detector k 、D2 k ；
Step 4, opening an air valve K11 and an air valve K17, and pumping the background air 1 filtered by the condensing chamber into the air cylinder by utilizing the air cylinder 600;
step 5, closing the air valve K11 and the air valve K17, opening the air valve K2 and the air valve K1, and pumping air 13 CO 2 Air chamber 700 12 CO 2 A gas chamber 800, thereby 13 CO 2 Air chamber 12 CO 2 Flushing out residual gas in the gas chamber;
step 6, repeating the step 4 and the step 5 twice, and closing the air valve K2 and the air valve K1; testing 13 CO 2 Air chamber 700 12 CO 2 The output value D1 of the detector T1 and the detector T2 when the air chamber 800 is filled with the bottom air 1 b 、D2 b ；
Step 7, opening the air valve K5 and the air valve K17, and pumping the sample gas 1 filtered by the condensing chamber into the air cylinder 600 by utilizing the air cylinder 600;
step 8, closing the air valve K5 and the air valve K17, opening the air valve K2 and the air valve K1, and pumping air into the air tank 13 CO 2 Air chamber 700 12 CO 2 A gas chamber 800, thereby 13 CO 2 Air chamber 700 12 CO 2 Residual gas in the gas chamber 800 is flushed out;
step 9, repeating the step 7 and the step 8 twice, and closing the air valve K2 and the air valve K1; testing 13 CO 2 Air chamber 700 12 CO 2 Detector T1 and output value D1 of detector T2 when gas cell 800 is filled with sample gas 1 y 、D2 y ；
Step 10, calculating the sample gas 1 and the bottom gas 1 13 C abundance difference:
wherein b is a correction coefficient.
It should be noted that, before the present detector works, all air valves are in a closed state, and fig. 1 only illustrates one connection state of the air pipe 300 and each component.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. While still being apparent from variations or modifications that may be made by those skilled in the art are within the scope of the utility model.
Claims (10)
1. A carbon 13 isotope analyzer, characterized by: including light source subassembly, air chamber, detector subassembly, trachea and pass through the condensing equipment of trachea intercommunication, install a plurality of pneumatic valves on the trachea, condensing equipment includes condensation chamber, refrigeration piece, radiating part, condensate box, intake pipe and outlet duct, the one end of intake pipe with the trachea intercommunication, the other end of intake pipe stretches into in the condensation chamber, the one end of outlet duct with the trachea intercommunication, the other end of outlet duct stretches into in the condensation chamber, the refrigeration piece is located the outside of condensation chamber, the radiating part is located the refrigeration piece is kept away from one side of condensation chamber.
2. The carbon 13 isotope analyzer of claim 1 wherein the condensate cartridge is removably disposed on one side of the condensing chamber, the condensate cartridge being in communication with the condensing chamber.
3. The carbon 13 isotope analyzer of claim 2 wherein the interior of the condensing chamber is disposed in a comb-like configuration.
4. The carbon 13 isotope analyzer of claim 1 wherein the heat sink is any one of a heat sink, a cold water drum, or a combination of a heat sink and any one of a fan, a cold water drum, and a fan.
5. The carbon 13 isotope analyzer of any one of claims 1-4, further comprising a filter assembly, a chopper, a stationary plenum, CO 2 Adsorption chamber and cylinder, wherein the CO 2 The adsorption chamber and the air cylinder are communicated with the air pipe, and the air valves comprise an air valve K1, an air valve K2 and an air valve K3 … … air valve K17, wherein the air valves K5 to K10 are sample air valves, and the air valves K11 to K16 are background air valves.
6. The carbon 13 isotope analyzer of claim 5 wherein the gas cell includes 13 CO 2 Air chamber 12 CO 2 An air chamber.
7. The carbon 13 isotope analyzer of claim 6 wherein the light source assembly includes light source L1 and light source L2, the detector assembly includes detector T1 and detector T2, and the filter assembly includes filter F1 and filter F2.
8. The carbon 13 isotope analyzer of claim 7 wherein the light source L1 is disposed within the chamber 13 CO 2 One end of the air chamber, anThe filter F1 and the detector T1 are arranged on the 13 CO 2 The other end of the air chamber.
9. The carbon 13 isotope analyzer of claim 7 wherein the light source L2 is disposed within the chamber 12 CO 2 One side of the air chamber, the filter F2 and the detector T2 are arranged on the 12 CO 2 The other side of the air chamber.
10. The carbon 13 isotope analyzer of any one of claims 7-9, wherein the stationary gas chamber is provided in the vessel 12 CO 2 Between the air chamber and the filter F2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321814385.6U CN220795030U (en) | 2023-07-11 | 2023-07-11 | Carbon 13 isotope analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321814385.6U CN220795030U (en) | 2023-07-11 | 2023-07-11 | Carbon 13 isotope analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220795030U true CN220795030U (en) | 2024-04-16 |
Family
ID=90660394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321814385.6U Active CN220795030U (en) | 2023-07-11 | 2023-07-11 | Carbon 13 isotope analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220795030U (en) |
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2023
- 2023-07-11 CN CN202321814385.6U patent/CN220795030U/en active Active
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