CN206862707U - A kind of new breathe-out air condensate gathering-device - Google Patents
A kind of new breathe-out air condensate gathering-device Download PDFInfo
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- CN206862707U CN206862707U CN201621244281.6U CN201621244281U CN206862707U CN 206862707 U CN206862707 U CN 206862707U CN 201621244281 U CN201621244281 U CN 201621244281U CN 206862707 U CN206862707 U CN 206862707U
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Abstract
A kind of new breathe-out air condensate gathering-device, including：Oral nose mask, collect subject's expiratory air；Cooling line, one end are connected with oral nose mask, and the other end is connected with sampling pipe；Refrigeration system, cooling line is acted on, expiratory air therein is cooled to below dew point, so that it is changed into condensate liquid；Wherein, the setting angle of cooling line, makes condensate liquid be fallen after rise by gravity in sampling pipe；The utility model also includes quantitative system, the liquid level in sampling pipe is monitored by way of optoelectronic induction, after the condensate liquid in sampling pipe reaches the liquid level of setting, send prompt message, terminate collection of specimens, the device can not disturb subject's eupnea, or gather exhaled breath condensate under using artificial aeration status, solve the problems, such as current new breathe-out air condensate gathering-device standard disunity, effect is unstable, automaticity is poor.
Description
Technical field
The utility model belongs to medical diagnosis technical field of auxiliary equipment, and more particularly to a kind of new exhaled breath condensate is received
Acquisition means.
Background technology
The pathological and physiological condition that the change of some compositions of expiratory air can reflect in intrapulmonary and air flue, after expiratory air is condensed
Formed liquid, its composition detection have the advantages that hurtless measure, it is simple to operation, can be repeated, High Risk of Lung Cancer people can be turned into
The novel means that group's examination, early stage auxiliary diagnosis, state of illness monitoring and curative effect judge.At present still in the exploratory stage, still have a lot
An open question, wherein expiratory air condensing unit are the important steps of this detection popularization and application.
The device collected for exhaled breath condensate mainly has 3 kinds：One is RTUBE portable units produced in USA, middle
PA tube is placed, condensed liquid is attachable to inner tubal wall；Two be the Ecoscreen that German Ai Lixi accumulates Co., Ltd's production
Electronic refrigerating plant；Also there is the report of self-control condensing unit the country in addition.These devices all wrap a refrigeration containing one-way cock
Pipe, suction gas and expiratory air can be separated, prevent from sucking expiratory air repeatedly.Subject 30~45min of mouth breathing, in condenser
Collect 1~3ml condensate liquids.The common deficiency of these devices is exactly that automaticity is not high, and condensation efficiency is low, it is difficult to quantitative to receive
Collection.
2004, Luo Fengming disclosed a kind of " new breathe-out air condensate gathering-device " (200420032424.8), led to
Cross subject to blow to T-shaped pipe, and T-shaped pipe is cooled down by semiconductor device, the liquid condensation in expiratory air is formed condensation
Liquid.The device is without automated system, uncontrollable collecting amount.And expiratory air is shorter by the regeneration path of the device, cooling
It is inefficient.
2008, Hua Shucheng et al. was disclosed a kind of " exhaled breath condensate (EBC) collection device "
(2008100050485.X), solve and taken out of with expiratory air by the upper curved design and " claw type " design of expiratory air export pipeline
Saliva raffinate enter refrigeration area influence, using SCM system to expiratory gas volume carry out detection realize condensate liquid is quantified
Change.Before the device sets the advantages of all same categories of device, and creatively solves the problems, such as ptyalin pollution.But
Still it is no to solve the problems, such as that condensation efficiency is low.In addition, controlling the collecting amount of condensate liquid by expiratory gas volume, itself is not smart
Really, because water content is not consistent in subject's expiratory air.
2016, Zhou Shanyong et al. was disclosed a kind of " new breathe-out air condensate gathering-device "
(201610235989.3), including the inner tube of condensate liquid and the outer tube being enclosed on outside inner tube are contained, outer tube upper end open is covered with soft
Property cap liner, serves the effect of check valve.The device does not have automation control system, without refrigeration system, by naturally cold
But.Therefore collection efficiency is low, belongs to portable easy device.
The content of the invention
The shortcomings that in order to overcome above-mentioned prior art, the purpose of this utility model are to provide a kind of new expiratory air condensation
Liquor collecting device, the device can collect the expiratory air of subject, and condensate liquid is transformed into by refrigerating plant, and automatically
Judge specimen tube liquid level and provide prompting solve that current exhaled breath condensate device effect is unstable, automaticity
The problem of poor.
To achieve these goals, the technical solution adopted in the utility model is：
A kind of new breathe-out air condensate gathering-device, including：
Oral nose mask 100, collect subject's expiratory air；
Cooling line 200, one end are connected with oral nose mask 100, and the other end is connected with sampling pipe 204；
Refrigeration system 300, cooling line 200 is acted on, expiratory air therein is cooled to below dew point, so that it changes
For condensate liquid；
Wherein, the setting angle of the cooling line 200, makes condensate liquid be fallen after rise by gravity in sampling pipe 204.
The oral nose mask 100 includes the cover body 120 that patient's mouth and nose can be completely covered, and the end face of cover body 120 is provided with silicon
Cushion rubber 110, front side, which is provided with, on cover body 120 allows air-flow to suck the air-breathing list in mask and preventing the expiratory air in mask from overflowing
To valve 130, the front of cover body 120 is provided with the expiratory one-way valve for allowing air-flow to be breathed out from mask and preventing air-flow from entering mask
140, expiratory one-way valve 140 is in the rubber hose 1 of connection cooling line 200.
The breather cheek valve 130 includes the spring 1 and ball in the taper air flue of front side on cover body 120
One 132, the wealthy mouth end of taper air flue is connected with cover body 120, and ball 1 is located at slot end, and normality lower spring 1 is withstood
Ball 1, clogging taper air flue；Face internal mask pressure declines during air-breathing, and spring 1 compresses, under ball 1
There is space in drop, taper air flue, it is allowed to which air-flow enters；
The expiratory one-way valve 140 includes spring 2 141 and ball in the taper air flue in the front of cover body 120
2 142, the wealthy mouth end of taper air flue is connected with rubber hose 1, and ball 2 142 is located at slot end, normality lower spring two
141 withstand ball 2 142, clogging taper air flue；Spring 2 141 compresses during expiration, and ball 2 142 moves forward, taper gas
There is space in road, it is allowed to which air-flow flows out.
The slot end of the taper air flue is provided with connecting port 133, to dock oxygen channel or lung ventilator.
The cooling line 200 includes spiral glass tube 202, and one end of spiral glass tube 202 passes through rubber hose 2 201
It is connected with oral nose mask 100, the other end is connected with sampling pipe 204, and refrigeration system 300 acts on spiral glass tube 202.
The refrigeration system 300 includes the cooling tank 310 of glass material, has refrigerant, cooling tank in cooling tank 310
310 upper and lower ends connection circulating water pipe 320, two groups of semiconductor coolers 340 are close to circulating water pipe 320, dropped for refrigerant
Temperature；Water circulating pump 350 flows for refrigerant in cooling tank 310 and circulating water pipe 320 provides power；Foam heat-insulation layer 330
Wrap up whole refrigeration system 300, heat exchange inside and outside barrier.
The semiconductor cooler 340 includes two groups of units, every group by cold piece 341, hot block 342 and be clipped in both
Between P-type semiconductor 343 and N-type semiconductor 344 form, access dc source 346, electric current through overheat block 342, two and half lead
Body, loop is formed after cold piece 341, from cold piece of end heat of transfer block end, two cold piece 341 is dropped heat to the circulating water pipe 320 being close to
Temperature, two hot blocks 342 are relative, cooled simultaneously to two hot blocks 342 by an axial flow blower 345.
The refrigerant composition is the Sodium Polyacrylate of mass fraction 12%, and 5% borax and 83% pure water are described cold
The material of block 341 and hot block 342 is brass；The matrix of two kinds of semi-conducting materials is pure silicon crystal, mixes molar concentration
P-type semiconductor 343 is made in 14% boron, and N-type semiconductor 344 is made in the phosphorus for participating in molar concentration 17%.
The utility model may also include quantitative system 400, and quantitative system 400 monitors sampling pipe by way of optoelectronic induction
Liquid level in 204, after the condensate liquid in sampling pipe 204 reaches the liquid level of setting, prompt message is sent, terminates mark
This collection, it can now realize full-automatic collection.
The quantitative system 400 includes：
LED 401, launch wavelength are 970nm visible rays, the middle and lower part of the transparent sampling pipe 204 of vertical irradiation；
Optoelectronic induction plate 402, the offside for being arranged at LED 401 is stood vertically, receive the light through sampling pipe 204, thoroughly
The light triggering optoelectronic induction crossed, electric signal is converted optical signal into relevant position；
Signal processor 403, it is connected with optoelectronic induction plate 402 and receives the electric signal；
Computer 404, it is connected with signal processor 403, liquid level electric signal analysis being scaled in sampling pipe 204
And show, when liquid level reaches setting height, prompting notice is sent, realizes that Full-automatic quantitative samples.
Compared with prior art, the utility model is not to disturb subject's eupnea, or is using artificial ventilation
Exhaled breath condensate is gathered under state, it is unstable to solve current new breathe-out air condensate gathering-device standard disunity, effect
Calmly, the problem of automaticity difference.
Brief description of the drawings
Fig. 1 is the utility model breathe-out air condensate gathering-device structure principle chart.
Fig. 2 is the structure principle chart of the utility model oral nose mask.
Fig. 3 is the structure principle chart of the utility model cooling line.
Fig. 4 is the utility model refrigerant system configurations schematic diagram.
Fig. 5 is the utility model quantitative system structure principle chart.
Embodiment
Describe embodiment of the present utility model in detail with reference to the accompanying drawings and examples.
As shown in figure 1, a kind of new breathe-out air condensate gathering-device of the utility model, including oral nose mask 100, cooling
Pipeline 200, refrigeration system 300, quantitative system 400 4 are most of.Oral nose mask 100 collects subject's expiratory air, subsequently enters
Expiratory air is cooled to below dew point by expiratory air cooling line 200, refrigeration system 300, and condensate liquid is fallen after rise into sampling by gravity
In pipe 204.Quantitative system 400 monitors the liquid level in sampling pipe 204 by way of optoelectronic induction, when cold in sampling pipe
After lime set reaches the liquid level of setting, prompt message is sent, terminates collection of specimens.Each part principle is as follows：
(1) oral nose mask
As shown in Fig. 2 oral nose mask 100 includes the cover body 120 that patient's mouth and nose can be completely covered, the end face of cover body 120 is set
Silica gel ring 110 is equipped with, is tightly bonded with skin of face by silica gel ring 110, avoids gas leakage.Cover body 120 is by medical PVC material system
Into front side, which is provided with, on cover body 120 allows air-flow to suck the breather cheek valve for preventing the expiratory air in mask from overflowing in mask
130, the front of cover body 120, which is provided with, allows air-flow to be breathed out from mask and prevent air-flow from entering the expiratory one-way valve 140 of mask, exhales
Gas check valve 140 is in the rubber hose 1 of connection cooling line 200.
Breather cheek valve 130 includes the spring 1 and ball one in the taper air flue of front side on cover body 120
132, the wealthy mouth end of taper air flue is connected with cover body 120, and ball 1 is located at slot end, and normality lower spring 1 withstands rubber
Glueballs 1, clogging taper air flue；Face internal mask pressure declines during subject's air-breathing, and spring 1 is compressed, ball one
132 decline, and space occurs in taper air flue, it is allowed to which air-flow enters；Face internal mask pressure rises when subject exhales, and spring 1 is extensive
It is normality again, the closing of taper air flue, prevents air-flow from entering.Top is that the slot end of taper air flue is provided with connecting port 133, can be with
Dock oxygen channel or lung ventilator.
Expiratory one-way valve 140 includes spring 2 141 and ball two in the taper air flue in the front of cover body 120
142, the wealthy mouth end of taper air flue is connected with rubber hose 1, and ball 2 142 is located at slot end, normality lower spring 2 141
Withstand ball 2 142, clogging taper air flue；Spring 2 141 compresses during expiration, and ball 2 142 moves forward, and taper air flue goes out
Existing space, it is allowed to which air-flow flows out.
Subject can be incorporated into by the oral nose mask 100 with general breathing, expiratory air, and pass through rubber hose 1
It is imported into cooling line 200.
(2) cooling line
Set as shown in figure 3, cooling line 200 is overall in vertical mode, including spiral glass tube 202, spiral glass tube
202 one end is connected by rubber hose 2 201 with oral nose mask 100, and the other end is connected with sampling pipe 204, refrigeration system 300
Act on spiral glass tube 202.
The expiratory air that mask is collected is imported into spiral glass tube 202 by rubber hose 2 201, and cooling down condensation herein turns into
Liquid, enter by Action of Gravity Field from liquid outlet 203 in the sampling pipe 204 of pure quartz material.
(3) refrigeration system
The effect of refrigeration system 300 is cooled for the spiral glass tube 202 in cooling line.As shown in figure 4, refrigeration system
System 300 is wrapped in the cooling tank 310 of the glass material outside spiral glass tube 202, has refrigerant in cooling tank 310
(composition is 12% Sodium Polyacrylate, 5% borax, 83% pure water), the upper and lower ends connection circulating water pipe 320 of cooling tank 310, two
Group semiconductor cooler 340 is close to circulating water pipe 320, cools for refrigerant；Water circulating pump 350 is refrigerant in cooling tank
310 and circulating water pipe 320 in flowing provide power；Foam heat-insulation layer 330 wraps up whole refrigeration system 300, heat inside and outside barrier
Exchange.
The composition and principle of semiconductor cooler 340 be：
Semiconductor cooler 340 includes two groups of units, and every group is situated between by cold piece 341, hot block 342 and folder
P-type semiconductor 343 and N-type semiconductor 344 form.The material of cold piece 341 and hot block 342 is brass；Two kinds of semi-conducting materials
Matrix be pure silicon crystal, P-type semiconductor 343 is made in the boron (molar concentration) for mixing 14%, participate in 17% phosphorus it is (mole dense
Degree) N-type semiconductor 344 is made.After accessing dc source 346, electric current shape after overheat block 342, two kind of semiconductor, cold piece 341
Into loop, electron transfer is produced between P and N-type semiconductor, so as to by heat from cold piece of end heat of transfer block end, two cold piece 341
Cool to the circulating water pipe 320 being close to, two hot blocks 342 are relative, and two hot blocks 342 are given simultaneously by an axial flow blower 345
Cooling.
(4) quantitative system
Liquid level in sampling pipe 204 is monitored using the principle of optoelectronic induction, the condensate liquid in sampling pipe 204
After the liquid level for reaching setting, prompt message is sent, terminates collection of specimens.
As shown in figure 5, quantitative system, using LED 401 that can be using launch wavelength as 970nm visible rays, vertical irradiation is saturating
About 1/3 position under in bright sampling pipe 204；Offside stands vertically optoelectronic induction plate 402, highly with slightly below sampling pipe 204, connects
Receive the light through sampling pipe 204；Due to exhaled breath condensate to the absorption peak of light near 970nm, therefore only liquid level
More than part can be with printing opacity, the light below liquid level is condensed liquid absorption；The light triggering optoelectronic induction of transmission, in light inductance
Answer the relevant position of plate 402 to convert optical signal into electric signal, signal processor 403 is passed to by cable；It is treated
Signal is passed to computer 404, and the liquid level being scaled by analysis in sampling pipe 204 is simultaneously shown, is set when liquid level reaches
When determining height, prompting notice is sent, realizes that Full-automatic quantitative samples.
The utility model implementation process is：
Subject's mouth and nose are completely covered using oral nose mask 100, expiratory air are imported into cooling line 200, by cold
But the cooling effect of system 300, the liquid component in expiratory air is condensed, forms exhaled breath condensate and fall into sampling pipe 204；
Quantitative system 400 monitors liquid level in real time by way of optoelectronic induction, when reach preset height preset sampling quantity after, send
Prompting notice, realize that Full-automatic quantitative samples.
Using the utility model breathe-out air condensate gathering-device, 24 volunteers are carried out with exhaled breath condensate collection and is surveyed
Examination, effect are as follows：
(1) 24 volunteer all successful collection to condensate liquid.
(2) collection capacity is set as 2ml, completes sample mean used time (14.2 ± 4.6) min；Accumulated simultaneously with German Ai Lixi
The electronic refrigerating plants of Ecoscreen of Co., Ltd's production, it is (34.5 ± 9.8) min to complete the 2ml exhalation liquid used times.
(3) set collection capacity as 2ml, after the completion of automatic alarm prompt, automation function is reliable and stable.
Claims (9)
- A kind of 1. new breathe-out air condensate gathering-device, it is characterised in that including：Oral nose mask (100), collect subject's expiratory air；Cooling line (200), one end are connected with oral nose mask (100), and the other end is connected with sampling pipe (204)；Refrigeration system (300), cooling line (200) is acted on, expiratory air therein is cooled to below dew point, so that it changes For condensate liquid；Wherein, the setting angle of the cooling line (200), makes condensate liquid be fallen after rise by gravity in sampling pipe (204).
- 2. new breathe-out air condensate gathering-device according to claim 1, it is characterised in that the oral nose mask (100) Cover body (120) including patient's mouth and nose can be completely covered, cover body (120) end face are provided with silica gel ring (110), cover body (120) Upper front side, which is provided with, allows air-flow to suck the breather cheek valve (130) for preventing the expiratory air in mask from overflowing in mask, cover body (120) front is provided with the expiratory one-way valve (140) for allowing air-flow to be breathed out from mask and preventing air-flow from entering mask, exhales single To valve (140) in the rubber hose one (150) of connection cooling line (200).
- 3. new breathe-out air condensate gathering-device according to claim 2, it is characterised in thatThe breather cheek valve (130) includes the spring one (131) and rubber in the taper air flue of front side on cover body (120) Ball one (132), the wealthy mouth end of taper air flue are connected with cover body (120), and ball one (132) is located at slot end, normality lower spring Withstand ball one (132), clogging taper air flue in one (131)；Face internal mask pressure declines during air-breathing, spring one (131) compression, Ball one (132) declines, and space occurs in taper air flue, it is allowed to which air-flow enters；The expiratory one-way valve (140) includes the spring two (141) and rubber in the taper air flue immediately ahead of cover body (120) Ball two (142), the wealthy mouth end of taper air flue are connected with rubber hose one (150), and ball two (142) is located at slot end, normality Lower spring two (141) withstands ball two (142), clogging taper air flue；Spring two (141) compresses during expiration, ball two (142) move forward, space occurs in taper air flue, it is allowed to which air-flow flows out.
- 4. new breathe-out air condensate gathering-device according to claim 3, it is characterised in that the slot of the taper air flue End is provided with connecting port (133), to dock oxygen channel or lung ventilator.
- 5. new breathe-out air condensate gathering-device according to claim 1, it is characterised in that the cooling line (200) Including spiral glass tube (202), one end of spiral glass tube (202) is connected by rubber hose two (201) and oral nose mask (100) Connect, the other end is connected with sampling pipe (204), and refrigeration system (300) acts on spiral glass tube (202).
- 6. new breathe-out air condensate gathering-device according to claim 1, it is characterised in that the refrigeration system (300) Cooling tank (310) including glass material, there is refrigerant in cooling tank (310), and the upper and lower ends connection of cooling tank (310) follows Ring water pipe (320), two groups of semiconductor coolers (340) are close to circulating water pipe (320), cool for refrigerant；Water circulating pump (350) for refrigerant, flowing provides power in cooling tank (310) and circulating water pipe (320)；Foam heat-insulation layer (330) wraps up Whole refrigeration system (300), heat exchange inside and outside barrier.
- 7. new breathe-out air condensate gathering-device according to claim 6, it is characterised in that the semiconductor cooler (340) two groups of units, every group of P-type semiconductor (343) being situated between by cold piece (341), hot block (342) and folder are included Formed with N-type semiconductor (344), access dc source (346), electric current is through overheating block (342), two kinds of semiconductors, cold piece (341) After form loop, heat is from cold piece of end heat of transfer block end, and two cold piece (341) give circulating water pipe (320) cooling being close to, two Hot block (342) cools simultaneously to two hot blocks (342) relatively, by an axial flow blower (345).
- 8. new breathe-out air condensate gathering-device according to claim 1, it is characterised in that also including quantitative system (400), quantitative system (400) monitors the liquid level in sampling pipe (204) by way of optoelectronic induction, works as sampling pipe (204) after the condensate liquid in reaches the liquid level of setting, prompt message is sent, terminates collection of specimens.
- 9. new breathe-out air condensate gathering-device according to claim 8, it is characterised in that the quantitative system (400) Including：LED (401), launch wavelength are 970nm visible rays, the middle and lower part of the transparent sampling pipe of vertical irradiation (204)；Optoelectronic induction plate (402), the offside for being arranged at LED (401) is stood vertically, receives the light through sampling pipe (204), The light triggering optoelectronic induction of transmission, electric signal is converted optical signal into relevant position；Signal processor (403), it is connected with optoelectronic induction plate (402) and receives the electric signal；Computer (404), it is connected with signal processor (403), liquid level electric signal analysis being scaled in sampling pipe (204) is high Spend and show, when liquid level reaches setting height, send prompting notice, realize that Full-automatic quantitative samples.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621244281.6U CN206862707U (en) | 2016-11-17 | 2016-11-17 | A kind of new breathe-out air condensate gathering-device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621244281.6U CN206862707U (en) | 2016-11-17 | 2016-11-17 | A kind of new breathe-out air condensate gathering-device |
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| Publication Number | Publication Date |
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| CN206862707U true CN206862707U (en) | 2018-01-09 |
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| CN201621244281.6U Expired - Fee Related CN206862707U (en) | 2016-11-17 | 2016-11-17 | A kind of new breathe-out air condensate gathering-device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106644606A (en) * | 2016-11-17 | 2017-05-10 | 西安培华学院 | Collection device of expired air condensed liquid |
| CN115184489A (en) * | 2022-07-01 | 2022-10-14 | 复旦大学 | System and method for collecting and detecting volatile organic compounds in exhaled breath |
-
2016
- 2016-11-17 CN CN201621244281.6U patent/CN206862707U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106644606A (en) * | 2016-11-17 | 2017-05-10 | 西安培华学院 | Collection device of expired air condensed liquid |
| CN115184489A (en) * | 2022-07-01 | 2022-10-14 | 复旦大学 | System and method for collecting and detecting volatile organic compounds in exhaled breath |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
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Granted publication date: 20180109 Termination date: 20211117 |