CN220729955U - Diffusion cell - Google Patents
Diffusion cell Download PDFInfo
- Publication number
- CN220729955U CN220729955U CN202322401326.2U CN202322401326U CN220729955U CN 220729955 U CN220729955 U CN 220729955U CN 202322401326 U CN202322401326 U CN 202322401326U CN 220729955 U CN220729955 U CN 220729955U
- Authority
- CN
- China
- Prior art keywords
- diffusion
- diffusion cell
- upper cover
- tank
- pipe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000009792 diffusion process Methods 0.000 title claims abstract description 74
- 239000011521 glass Substances 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 238000003780 insertion Methods 0.000 claims abstract description 4
- 230000037431 insertion Effects 0.000 claims abstract description 4
- 238000007789 sealing Methods 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 9
- 230000003247 decreasing effect Effects 0.000 claims description 8
- 230000007246 mechanism Effects 0.000 claims description 8
- 239000003814 drug Substances 0.000 abstract description 19
- 238000009434 installation Methods 0.000 abstract description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 11
- 239000000741 silica gel Substances 0.000 description 11
- 229910002027 silica gel Inorganic materials 0.000 description 11
- 230000008859 change Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000010030 laminating Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 238000009529 body temperature measurement Methods 0.000 description 3
- 230000004308 accommodation Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Devices For Use In Laboratory Experiments (AREA)
Abstract
The utility model belongs to the technical field of diffusion cells, in particular to a diffusion cell which comprises a diffusion cell, a receiving cell upper cover arranged above the diffusion cell, an elastic fixing clamp arranged at the joint of the diffusion cell and the receiving cell upper cover, and a temperature control assembly arranged on the surface of the diffusion cell; the temperature control assembly comprises a glass cavity and a through pipe, wherein the glass cavity is respectively arranged on the surfaces of the diffusion tank and the upper cover of the receiving tank, the through pipe is symmetrically arranged on the surfaces of the glass cavity and provided with through holes, the glass cavity is arranged on the surfaces of the diffusion tank and the upper cover of the receiving tank during use, the constant temperature water tank is matched with the through pipe arranged on the glass cavity through a rubber hose, the constant temperature water tank is matched with the through pipe, the medicine diffusion rate at different temperatures can be carried out through adjusting the water temperature in the constant temperature water tank, the flexibility is high, the connecting assembly is matched, the rubber hose is inserted into the surface of an insertion pipe during use, the rubber hose is fixed on the surface of the insertion pipe through the sliding tightening sleeve, and the use and the installation are more convenient.
Description
Technical Field
The utility model belongs to the technical field of diffusion cells, and particularly relates to a diffusion cell.
Background
The main method adopted in the transdermal diffusion test of the transdermal administration preparation is a diffusion cell method, the method can reflect the speed and degree of permeation of the medicine through the living skin of animals, and can screen the prescription of the transdermal absorption medicine preparation, and is one of the currently internationally accepted standard detection methods of the transdermal release of the medicine, and the diffusion cell is generally used for testing the permeability of the medicine when the transdermal release test of the medicine is carried out;
through investigation publication (bulletin) number: CN218067549U discloses a Logan diffusion cell, this technology discloses a "Logan diffusion cell, including donor cover, acceptor cover, glass tube, base, silica gel pad and membrane, the upper and lower both ends of glass tube can be dismantled and connect acceptor cover and base separately, the bottom of the inner cavity of base has stirring device, the top of acceptor cover is the plane setting, the centre of acceptor cover is equipped with the through-hole, and set up membrane and silica gel pad between acceptor cover and the donor cover, the membrane laminating sets up in acceptor cover top and covers the through-hole, the silica gel pad laminating sets up on membrane, the silica gel pad centre has offered the accommodation hole used for placing the medicament, the bottom of donor cover is the plane setting, and the centre of donor cover is equipped with technical contents such as administration hole, and disclosed this Logan diffusion cell, make the glass tube connect with the acceptor cover and base for dismantling, easy to dismantle and wash, and can change the acceptor cover of different through-hole sizes, be applicable to different concentration size medicament, realize the effect of administering in a large amount or small amount, through changing the silica gel pad of different thickness, realize the technical effects such as dose of medicament size;
although the design can be disassembled and cleaned conveniently, is suitable for medicines with different concentrations, and can change the medicine dosage by changing silica gel pads with different thicknesses, the diffusion cell is inconvenient in adjusting and controlling the internal temperature during experiments, the permeation speed of the medicines at different temperatures is difficult to measure, and the accuracy of detection results is affected;
in order to solve the above problems, a diffusion cell is proposed in the present application.
Disclosure of Invention
To solve the problems set forth in the background art. The utility model provides a diffusion cell which has the characteristic of being convenient for carrying out the diffusion rate of substances at different temperatures.
In order to achieve the above purpose, the present utility model provides the following technical solutions: a diffusion cell comprises a diffusion cell, a receiving cell upper cover arranged above the diffusion cell, an elastic fixing clamp arranged at the joint of the diffusion cell and the receiving cell upper cover, and a temperature control assembly arranged on the surface of the diffusion cell;
the temperature control assembly comprises a glass cavity, a through pipe and a constant-temperature water tank, wherein the glass cavity is respectively arranged on the surfaces of the diffusion tank and the receiving tank, the through pipe is symmetrically arranged in a through hole formed in the surface of the glass cavity, the constant-temperature water tank is arranged on the outer side of the diffusion tank, and the constant-temperature water tank is connected with the through pipe through a rubber hose arranged on the outer side of the glass cavity.
Preferably, as a diffusion cell of the present utility model, a heating mechanism is mounted on the surface of the constant temperature water tank.
Preferably, as a diffusion cell of the present utility model, a surface of the constant temperature water tank is provided with a temperature display.
In one preferred embodiment of the diffusion cell of the present utility model, a second sealing ring is installed on a surface of one side of the diffusion cell, which is close to the upper cover of the receiving cell, and a first sealing ring is installed on a surface of the upper cover of the receiving cell, which is close to the diffusion cell, and the first sealing ring is in abutting connection with the second sealing ring.
As a preferred diffusion cell of the utility model, the surface of the upper cover of the receiving cell is clamped with a glass cover with a T-shaped structure.
Preferably, the diffusion cell further comprises a connecting assembly arranged on the surface of the through pipe, wherein the connecting assembly comprises a cannula arranged on the surface of the through pipe and a tightening sleeve sliding on the surface of the cannula, and a friction pad is arranged on the inner wall of the tightening sleeve.
As a preferred diffusion cell of the utility model, the insertion tube is arranged in a cylindrical structure gradually decreasing from outside to inside, and the tightening sleeve is arranged in a circular ring structure gradually decreasing from outside to inside.
Compared with the prior art, the utility model has the beneficial effects that:
when the device is used, the glass cavity is arranged on the surface of the upper cover of the receiving tank through the diffusion tank, the constant-temperature water tank is matched with the through pipe arranged on the glass cavity through the rubber hose, the medicine diffusion rate at different temperatures can be carried out through adjusting the water temperature in the constant-temperature water tank, the flexibility is high, the device is matched with the connecting assembly, the rubber hose is inserted into the surface of the cannula during the use, the rubber hose is fixed on the surface of the cannula through the sliding tightening sleeve, the structure is simple, and the device is more convenient to use and install.
Drawings
The accompanying drawings are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this specification, illustrate the utility model and together with the embodiments of the utility model, serve to explain the utility model. In the drawings:
FIG. 1 is a schematic diagram of the structure of the present utility model;
FIG. 2 is a schematic cross-sectional view of a glass chamber according to the present utility model;
FIG. 3 is a schematic view of a connecting assembly according to the present utility model;
FIG. 4 is a schematic diagram of the overall structure of the present utility model;
in the figure: 1. a diffusion cell; 11. a receiving tank upper cover; 12. an elastic fixing clip;
2. a temperature control assembly; 21. a glass cavity; 22. a through pipe; 23. a rubber hose; 24. a constant temperature water tank; 25. a heating mechanism; 26. a temperature display; 27. a first seal ring; 28. a second seal ring; 29. a glass cover;
3. a connection assembly; 31. a cannula; 32. tightening the sleeve.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Example 1
As shown in fig. 1-4;
a diffusion cell comprises a diffusion cell 1, a receiving cell upper cover 11 arranged above the diffusion cell 1, and an elastic fixing clip 12 arranged at the joint of the diffusion cell 1 and the receiving cell upper cover 11.
In this embodiment: through investigation publication (bulletin) number: CN218067549U discloses a log an diffusion cell, this technique is disclosed "a log an diffusion cell, including donor lid, the acceptor lid, the glass tube, the base, silica gel pad and diaphragm, both ends can be dismantled respectively about the glass tube and connect acceptor lid and base, base inner chamber bottom is equipped with agitating unit, the acceptor lid top is the plane setting, the acceptor lid center runs through and is equipped with the through-hole, and set up diaphragm and silica gel pad between acceptor lid and the donor lid, the diaphragm laminating sets up in acceptor lid top and covers the through-hole, the silica gel pad laminating sets up on the diaphragm, the accommodation hole that is used for placing the medicine has been seted up at silica gel pad center, donor lid bottom is the plane setting, and donor lid center runs through and is equipped with technical content such as dosing hole, and disclosed this kind of log an diffusion cell, make and be detachably connected between glass tube and the acceptor lid and the base, the convenient for dismantle and wash, and can change the acceptor lid of different through-hole sizes, be applicable to the medicine of different concentration size, realize a large amount of dosing or effect of dosing, through changing the silica gel pad of different thickness, the realization is to the medicine pad of medicine of different thickness, the temperature is the difference is the temperature-controlled and is the temperature-sensitive and is difficult to be connected at the temperature-sensitive to the temperature-sensitive device, the temperature control is realized, the temperature control is difficult to change, the temperature control is realized, the temperature is convenient to change is actually and is difficult to change, the temperature measurement is measured and is difficult to be connected at the temperature control and is difficult to realize the temperature measurement and the temperature measurement is compared, and convenient to be measured.
In combination with the above, the temperature control assembly 2 is arranged on the surface of the diffusion tank 1, the temperature control assembly 2 comprises a glass cavity 21 which is respectively arranged on the surfaces of the diffusion tank 1 and the receiving tank upper cover 11, a through pipe 22 which is symmetrically arranged in a through hole formed in the surface of the glass cavity 21, and a constant temperature water tank 24 which is arranged on the outer side of the diffusion tank 1, wherein the constant temperature water tank 24 is connected with the through pipe 22 through a rubber hose 23 which is arranged on the outer side of the glass cavity 21.
In this embodiment: when in use, the glass cavity 21 is arranged on the surfaces of the diffusion tank 1 and the receiving tank upper cover 11, the constant temperature water tank 24 is matched with the through pipe 22 arranged on the glass cavity 21 through the rubber hose 23, and the medicine diffusion rate at different temperatures can be carried out by adjusting the water temperature in the constant temperature water tank 24, so that the structure is simple, and the flexibility is strong.
In an alternative embodiment, the surface of the thermostatic waterbox 24 is provided with a heating mechanism 25.
In this embodiment: when the heating mechanism 25 is arranged for use, the heating mechanism 25 is convenient for heating the water temperature in the constant-temperature water tank 24 to a proper test temperature.
In an alternative embodiment, the surface of the thermostatic waterbox 24 is fitted with a temperature display 26.
In this embodiment: the temperature display 26 is arranged to conveniently read the temperature in the constant temperature water tank 24, so that the temperature can be conveniently observed.
It should be noted that: a temperature sensor is disposed within the thermostatic waterbox 24 in signal communication with a temperature display 26. The reading is more convenient.
In an alternative embodiment, a second sealing ring 28 is mounted on the surface of the diffusion cell 1 near the upper cover 11 of the receiving cell, and a first sealing ring 27 is mounted on the surface of the upper cover 11 of the receiving cell near the diffusion cell 1, and the first sealing ring 27 and the second sealing ring 28 are in abutting connection.
In this embodiment: by providing the second seal ring 28 and the first seal ring 27, the sealing effect between the diffusion cell 1 and the receiving-cell upper cover 11 can be improved.
In an alternative embodiment, the surface of the receiving well top cover 11 is snapped with a T-shaped structured glass cover 29.
In this embodiment: the glass cover 29 with the T-shaped structure can seal the upper cover 11 of the receiving tank, so that the receiving tank is prevented from being polluted by the outside.
Still further, the method comprises:
in combination with the above, the connecting assembly 3 is arranged on the surface of the through pipe 22, the connecting assembly 3 comprises a cannula 31 arranged on the surface of the through pipe 22 and a tightening sleeve 32 sliding on the surface of the cannula 31, and a friction pad is arranged on the inner wall of the tightening sleeve 32.
In this embodiment: and cooperate coupling assembling 3, through inserting the surface of intubate 31 with rubber hose 23 during the use, through sliding tightening sleeve 32 with rubber hose 23 fixed at the surface of intubate 31, it is more convenient to use the installation.
In an alternative embodiment, the cannula 31 is arranged in a tapered cylindrical configuration from outside to inside, and the tightening sleeve 32 is arranged in a tapered annular configuration from outside to inside.
In this embodiment: by arranging the cannula 31 in a cylindrical structure gradually decreasing from outside to inside, the tightening sleeve 32 is arranged in a circular ring structure gradually decreasing from outside to inside, and the rubber hose 23 is conveniently fixed to the surface of the cannula 31 by moving the tightening sleeve 32.
The working principle and the using flow of the utility model are as follows: during the use through at diffusion cell 1 and accept pond upper cover 11 surface mounting glass cavity 21, cooperation constant temperature water tank 24 is connected with the siphunculus 22 of installing on the glass cavity 21 through rubber hose 23, through adjusting the temperature in the constant temperature water tank 24, can carry out the medicine diffusion rate under different temperatures, and a structure is simple, and is strong in flexibility, when using through setting up heating mechanism 25, make things convenient for heating mechanism 25 to the temperature in the constant temperature water tank 24 to suitable test temperature, can conveniently read the temperature in the constant temperature water tank 24 through setting up temperature display 26, convenient observation, through setting up second sealing washer 28 and first sealing washer 27, can improve the sealed effect between diffusion cell 1 and the accept pond upper cover 11, can seal up the pond upper cover 11 through setting up T shape structure, avoid receiving external pollution, and cooperate coupling assembling 3, through inserting the surface of intubate 31 with rubber hose 23, through sliding tightening up cover 32 with rubber hose 23 fixed at the surface of intubate 31, use installation is more convenient, through setting up the intubate 31 and gradually decreasing gradually the structure is the internal tightening up to the annular 32 and gradually the annular setting up to the intubate 31 and gradually decreasing up the annular structure is fixed to the intubate 31.
Finally, it should be noted that: the foregoing description is only a preferred embodiment of the present utility model, and the present utility model is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present utility model has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model should be included in the protection scope of the present utility model.
Claims (7)
1. A diffusion cell, includes diffusion cell (1) and sets up accept pond upper cover (11) and setting in diffusion cell (1) top are in diffusion cell (1) with accept elasticity fixation clamp (12) of pond upper cover (11) junction, its characterized in that: the temperature control assembly (2) is arranged on the surface of the diffusion tank (1);
the temperature control assembly (2) comprises a glass cavity (21) which is respectively arranged on the surfaces of the diffusion tank (1) and the receiving tank upper cover (11), a through pipe (22) which is symmetrically arranged in a through hole formed in the surface of the glass cavity (21), and a constant-temperature water tank (24) which is arranged on the outer side of the diffusion tank (1), wherein the constant-temperature water tank (24) is connected with the through pipe (22) through a rubber hose (23) which is arranged on the outer side of the glass cavity (21).
2. A diffusion cell according to claim 1, wherein: the surface of the constant temperature water tank (24) is provided with a heating mechanism (25).
3. A diffusion cell according to claim 1, wherein: the surface of the constant temperature water tank (24) is provided with a temperature display (26).
4. A diffusion cell according to claim 1, wherein: one side surface of diffusion cell (1) is close to accept pond upper cover (11) is installed second sealing washer (28), accept pond upper cover (11) and be close to the surface mounting of diffusion cell (1) has first sealing washer (27), first sealing washer (27) with second sealing washer (28) conflict is connected.
5. A diffusion cell according to claim 1, wherein: the surface of the receiving tank upper cover (11) is clamped with a glass cover (29) with a T-shaped structure.
6. A diffusion cell according to claim 1, wherein: the connecting assembly (3) is arranged on the surface of the through pipe (22), the connecting assembly (3) comprises a cannula (31) arranged on the surface of the through pipe (22) and a tightening sleeve (32) sliding on the surface of the cannula (31), and a friction pad is arranged on the inner wall of the tightening sleeve (32).
7. A diffusion cell according to claim 6, wherein: the insertion tube (31) is arranged in a cylinder structure gradually decreasing from outside to inside, and the tightening sleeve (32) is arranged in a ring structure gradually decreasing from outside to inside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322401326.2U CN220729955U (en) | 2023-09-05 | 2023-09-05 | Diffusion cell |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322401326.2U CN220729955U (en) | 2023-09-05 | 2023-09-05 | Diffusion cell |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220729955U true CN220729955U (en) | 2024-04-05 |
Family
ID=90498833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322401326.2U Active CN220729955U (en) | 2023-09-05 | 2023-09-05 | Diffusion cell |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220729955U (en) |
-
2023
- 2023-09-05 CN CN202322401326.2U patent/CN220729955U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4594884A (en) | Diffusion measuring device | |
| CN220729955U (en) | Diffusion cell | |
| CN218491747U (en) | Multi-channel rumen fluid in-vitro fermentation gas production measuring device | |
| CN103808628B (en) | Blood culture carbon dioxide trace gas detection system and detection method thereof | |
| CN211262909U (en) | Excrement and urine detection sample making devices | |
| CN201313900Y (en) | Patch clamp constant-temperature device | |
| CN207096112U (en) | Formaldehyde examination pipe and formaldehyde examination device | |
| CN210401006U (en) | Device for preparing saturated dissolved oxygen water | |
| CN209014155U (en) | A kind of fixation device for thermometer detection | |
| CN203610054U (en) | Simple film yarn flux test system | |
| CN209412216U (en) | A kind of coliform detection device | |
| CN215677175U (en) | Thermal gas mass flow meter convenient to connect | |
| CN219032188U (en) | Nucleic acid detection device | |
| CN217845980U (en) | Vertical transdermal diffusion cell | |
| CN206258384U (en) | Color contrast formula glycosuria state of an illness detection means | |
| CN109632782A (en) | A kind of integral type multichannel constant pressure automatic liquid matching display device | |
| CN203572826U (en) | Device for determining seawater shellfish oxygen consumption rate | |
| CN218026104U (en) | Detection assembly and biological reaction detection system convenient for real-time monitoring of biological culture parameters and states | |
| US7901931B2 (en) | Cell for measuring biological activities and/or physiological parameters of micro-organisms | |
| CN212083307U (en) | Equipment for measuring pH value of oil | |
| CN219589741U (en) | Thermal flowmeter | |
| CN218331201U (en) | Metering device or colorimetric device for water quality analysis | |
| CN218004264U (en) | Cerebrospinal fluid in-vitro simulation circulating system | |
| CN220154338U (en) | Rotary electrode electrochemical detection device | |
| CN216747606U (en) | Novel portable device for nondestructive microenvironment test cabin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |