CN218026104U - Detection assembly and biological reaction detection system convenient for real-time monitoring of biological culture parameters and states - Google Patents
Detection assembly and biological reaction detection system convenient for real-time monitoring of biological culture parameters and states Download PDFInfo
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- CN218026104U CN218026104U CN202221607636.9U CN202221607636U CN218026104U CN 218026104 U CN218026104 U CN 218026104U CN 202221607636 U CN202221607636 U CN 202221607636U CN 218026104 U CN218026104 U CN 218026104U
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Abstract
The utility model discloses a component convenient for real-time monitoring of cell culture parameters and states, which comprises a metering pump, a conduit and a detection platform capable of monitoring biological culture parameters and states in real time, wherein the metering pump comprises a pump pipe and a pump body, one conduit is hermetically connected with the pump pipe on one side of the pump body and one side of the detection platform, and the other conduit is hermetically connected with the other side of the detection platform; the utility model also discloses a biological reaction detection system convenient for real-time monitoring of biological culture parameters and states, which comprises the detection component, the connecting pipe and the bioreactor/cell culture device, the other conduit is in integral sealing connection or detachable sealing connection with the bioreactor/cell culture device, and the pump pipe at the other side of the pump body is in integral sealing connection or detachable sealing connection with the bioreactor/cell culture device; the utility model discloses can reduce the sample analysis and detect the probability that leads to the sample pollution, improve the timeliness that sample analysis and detect and simplify sample analysis and detect operation flow.
Description
Technical Field
The utility model relates to a biological cell culture, detection technology field, concretely relates to determine module and biological reaction detecting system convenient to real-time supervision biological cultivation parameter, state.
Background
At present, because a bioreactor/cell culture device needs to detect culture parameters such as the pH value and the temperature of a culture solution, and observe information such as the number and the growth state of organisms in the bioreactor/cell culture device, a plurality of interfaces must be reserved on the bioreactor/cell culture device for installing a detection sensor and/or sampling detection, the detection sensor and/or sampling detector can enter the bioreactor/cell culture device through the corresponding interface, so that the situation that substances in the bioreactor/cell culture device leak or external pollutants enter the reactor can occur, and problems such as complex operation, sample pollution, poor timeliness and the like can exist in sampling analysis and detection.
SUMMERY OF THE UTILITY MODEL
In order to solve the problem, the utility model provides a determine module and biological reaction detecting system convenient to biological cultivation parameter of real-time supervision and state can reduce the probability that sample analysis and detection leads to the sample pollution, improve sample analysis and detection's ageing and simplify sample analysis and detection operation flow.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
the utility model provides a determine module convenient to real-time supervision is biological cultivates parameter, state, includes measuring pump, pipe and the detection platform that can real-time supervision biological cultivation parameter, state, the measuring pump includes pump line and the pump body, the pump line passes the pump body, and one of them pipe sealing connects the pump line of pump body one side and one side of detecting the platform, another pipe sealing connects in the opposite side of detecting the platform.
Furthermore, the detection table comprises a plurality of detection units which are sequentially connected in series and are mutually and hermetically connected.
Further, the detection unit is a sheet-shaped platform with a hollow interior.
Furthermore, the detection unit is made of transparent materials.
Furthermore, the transparent material is a glass sheet and/or a transparent plastic sheet.
Further, the metering pump is a metering peristaltic pump.
Further, the conduit is a hose.
Furthermore, one of the guide pipes and the pump pipe on one side of the pump body are in integral sealing connection or detachable sealing connection.
Furthermore, the cross-sectional areas of the pump tube, the guide tube and the cross-sectional area of each position in the inner pipeline formed by the detection platform are equal.
The utility model provides a biological reaction detecting system convenient to real-time supervision biological cultivation parameter, state, includes foretell determine module, connecting pipe and bioreactor/cell culture ware, another pipe with bioreactor/cell culture ware be sealing connection or can dismantle sealing connection as an organic whole, the integrative sealing connection of connecting pipe or can dismantle sealing connection the pump line of pump body opposite side with bioreactor/cell culture ware.
Adopt as above technical scheme, the utility model discloses a but measurement peristaltic pump, pipe and real-time supervision biological cultivation parameter, the cooperation structure of the detection platform of state make the utility model discloses a detection subassembly can directly install in bioreactor/cell culture ware, forms the utility model discloses a biological reaction detecting system, after measurement peristaltic pump begins work, can make the material in bioreactor/cell culture ware flow to detecting the platform via the pipe and detect, later flow back to bioreactor/cell culture ware by the pump line of measurement peristaltic pump again in for bioreactor/cell culture ware need not to leave a plurality of interfaces again, and need not a plurality of detection sensor installations and sampling detector's installation, thereby lets the utility model discloses can simplify the sampling analysis and detection operation flow, improve sampling analysis and detection's ageing nature to reduce the probability that sampling analysis and detection lead to the sample pollution.
Drawings
Fig. 1 is a schematic perspective view of the detecting assembly of the present invention;
fig. 2 is a schematic diagram of the three-dimensional structure of the biological reaction detecting system of the present invention.
[ description of symbols ]
Metering pump 1
Catheter 2
Detection table 3
Bioreactor/cell culture apparatus 4
The connecting tube 5.
Detailed Description
To further illustrate the embodiments, the present invention provides the accompanying drawings. The accompanying drawings, which are incorporated in and constitute a part of this disclosure, illustrate embodiments of the invention and, together with the description, serve to explain the principles of the embodiments. With these references, one of ordinary skill in the art will appreciate other possible embodiments and advantages of the present invention. Elements in the figures are not drawn to scale and like reference numerals are generally used to indicate like elements.
The present invention will now be further described with reference to the accompanying drawings and detailed description.
Referring to fig. 1, the utility model discloses a detection assembly convenient for real-time monitoring of biological culture parameters and states, which comprises a metering pump 1, a conduit 2 and a detection platform 3 capable of real-time monitoring of biological culture parameters and states, wherein the metering pump 1 comprises a pump pipe 11 and a pump body 12, the pump pipe 11 passes through the pump body 12, one conduit 2 is hermetically connected with the pump pipe 11 at one side of the pump body 12 and one side of the detection platform 3, and the other conduit 2 is hermetically connected with the other side of the detection platform 3; wherein, the detection platform 3 can be a hollow pipeline structure.
Therefore, the utility model discloses a measuring pump 1, but pipe 2 and real-time supervision biological cultivation parameter, the cooperation structure of the test table 3 of state, make the utility model discloses a detection module can directly install in bioreactor/cell culture ware 4, forms the utility model discloses a biological reaction detecting system, after measuring pump 1 begins to work, can make the material in bioreactor/cell culture ware 4 flow to detecting table 3 via pipe 2 and detect, later flow back to bioreactor/cell culture ware 4 by the pump line 11 of measuring pump 1 again for bioreactor/cell culture ware 4 need not to reserve a plurality of interfaces again, and need not a plurality of detection sensor installations and sampling test ware's installation, thereby lets the utility model discloses sample analysis and detection operation flow can be simplified, sample analysis and detection's timeliness is improved to reduce the probability that sample analysis and detection leads to sample pollution.
In order to facilitate the simultaneous detection of various parameters and states of substances in the bioreactor/cell culture apparatus 4, the detection station 3 comprises a plurality of detection units 31 connected in series and hermetically connected to each other; the detection units 31 are respectively used for detecting different biological culture parameters and states.
Further, the detecting unit 31 may be a thin plate-like platform with a hollow inside.
In order to facilitate observation of the number, density and growth status of the living organisms in the detecting unit 31, the detecting unit 31 may be made of a transparent material.
Further, the transparent material is a glass sheet and/or a transparent plastic sheet, and can be a full glass sheet, a full plastic film or a combination of the glass sheet and the plastic sheet according to needs.
In order to accurately meter the amount of substance in the detection unit 31, the metering pump 1 is preferably a metering peristaltic pump 1.
Preferably, the conduit 2 is a hose.
Furthermore, one of the guide pipes 2 and the pump pipe 11 on one side of the pump body 12 can be in integral sealing connection or detachable sealing connection; if one of the conduits 2 is connected to the pump tube 11 on the pump body 12 side in an integral sealing manner, the sealing performance is good, the conduit is not easy to break when in use, and the number of connection joints can be reduced. If one of the guide tubes 2 is detachably and hermetically connected with the pump tube 11 on one side of the pump body 12, the guide tube 2 or the pump tube 11 can be independently replaced, so that the maintenance is convenient, and the disposable product or component is convenient to manufacture.
In addition, the cross sections of all positions in the internal pipeline formed by the pump pipe 11, the guide pipe 2 and the detection platform 3 are equal in area, so that the flowing resistance of substances in the pipeline at all positions is low, and the uniform-speed liquid circulation is ensured.
Please refer to fig. 2, the present invention further discloses a biological reaction detecting system for real-time monitoring of biological culture parameters and status, which comprises the detecting assembly, a connecting pipe 5 and a bioreactor/cell culture device 4, wherein another pipe 2 is integrally and hermetically connected or detachably and hermetically connected with the bioreactor/cell culture device 4, the connecting pipe 5 is integrally and hermetically connected or detachably and hermetically connected with the pump pipe 11 at the other side of the pump body 12 and the bioreactor/cell culture device 4; if the pump tube 11 on the other side of the pump body 12 is connected with the bioreactor/cell culture device 4 in an integrated sealing manner, the whole system can be a disposable product or a reusable product, and if the pump tube 11 on the other side of the pump body 12 is connected with the bioreactor/cell culture device 4 in a detachable sealing manner, part of components can be made into a disposable product.
In summary, when performing cell culture or biological reaction, the whole biological reaction detecting system of the present invention can be placed in a container or environment such as an incubator or a thermostatic chamber that meets the environmental requirements of cell growth or biological reaction, and the cells or organisms in the bioreactor/cell culture apparatus grow or react under suitable conditions; when biological culture parameters and states need to be monitored, the metering pump 1 is started, the metering pump 1 pumps substances in the bioreactor/cell culture device 4 into the guide pipe 2, when the substances flow through the detection table 3, the detection devices which are arranged at the detection table 3 and matched with the detection units 31 are started, the biological culture parameters and states are respectively detected in a non-contact mode, and after the detection is finished, the substances in the guide pipe 2 flow back into the bioreactor/cell culture device 4, so that the online monitoring of the biological culture parameters and states in the bioreactor/cell culture device 4 is completed; wherein, because of detecting platform 3 including a plurality of detecting element 31 of series connection in proper order and sealing connection, every detecting element 31 can form a complete set and correspond a detection device, can detect each parameter and the state of material in bioreactor/cell culture ware 4 simultaneously, for example temperature, pH valve, oxygen content, biological quantity/density and biological growth state etc. and the utility model discloses an entire system is closed system again, and the testing process does not influence biological growth and reaction to be convenient for carry out real-time detection, obtain biological reaction's real-time growth state, detect in cell culture or biological reaction in-process in the lump.
While the invention has been particularly shown and described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. The utility model provides a determine module convenient to real-time supervision biological cultivation parameter, state which characterized in that: but including measuring pump, pipe and real-time supervision biological cultivation parameter, the test table of state, the measuring pump includes pump line and the pump body, the pump line passes the pump body, and one of them pipe sealing connects the pump line of pump body one side and the one side of examining the test table, another pipe sealing connects in the opposite side of examining the test table.
2. A sensing assembly for facilitating real-time monitoring of biological growth parameters and conditions as defined in claim 1, wherein: the detection table comprises a plurality of detection units which are sequentially connected in series and are mutually and hermetically connected.
3. A sensing assembly for facilitating real-time monitoring of biological growth parameters and conditions as defined in claim 2, wherein: the detection unit is a sheet-shaped platform with a hollow interior.
4. A sensing assembly for facilitating real-time monitoring of biological growth parameters and conditions as defined in claim 3, wherein: the detection unit is made of transparent materials.
5. The detection assembly for facilitating real-time monitoring of parameters and conditions of a biological culture of claim 4, wherein: the transparent material is a glass sheet and/or a transparent plastic sheet.
6. A sensing assembly for facilitating real-time monitoring of biological growth parameters and conditions as defined in claim 1, wherein: the metering pump is a metering peristaltic pump.
7. A sensing assembly for facilitating real-time monitoring of biological growth parameters and conditions as defined in claim 1, wherein: the conduit is a hose.
8. The detection assembly for facilitating real-time monitoring of parameters and conditions of a biological culture of claim 7, wherein: one guide pipe and the pump pipe on one side of the pump body are in integral sealing connection or detachable sealing connection.
9. A sensing assembly for facilitating real-time monitoring of biological growth parameters and conditions as claimed in any one of claims 1 to 8, wherein: the cross sections of all positions in an internal pipeline formed by the pump pipe, the guide pipe and the detection table are equal in area.
10. The utility model provides a biological reaction detecting system convenient to real-time supervision biological cultivation parameter, state which characterized in that: comprises a detection assembly as claimed in any one of claims 1 to 9, a connecting pipe and a bioreactor/cell culture device, wherein another conduit is integrally and hermetically connected or detachably and hermetically connected with the bioreactor/cell culture device, and the connecting pipe is integrally and hermetically connected or detachably and hermetically connected with a pump pipe on the other side of the pump body and the bioreactor/cell culture device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221607636.9U CN218026104U (en) | 2022-06-24 | 2022-06-24 | Detection assembly and biological reaction detection system convenient for real-time monitoring of biological culture parameters and states |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221607636.9U CN218026104U (en) | 2022-06-24 | 2022-06-24 | Detection assembly and biological reaction detection system convenient for real-time monitoring of biological culture parameters and states |
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| Publication Number | Publication Date |
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| CN218026104U true CN218026104U (en) | 2022-12-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202221607636.9U Active CN218026104U (en) | 2022-06-24 | 2022-06-24 | Detection assembly and biological reaction detection system convenient for real-time monitoring of biological culture parameters and states |
Country Status (1)
| Country | Link |
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| CN (1) | CN218026104U (en) |
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2022
- 2022-06-24 CN CN202221607636.9U patent/CN218026104U/en active Active
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