CN220685084U - Device for separating and purifying exosomes from supernatant - Google Patents
Device for separating and purifying exosomes from supernatant Download PDFInfo
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- CN220685084U CN220685084U CN202322294450.3U CN202322294450U CN220685084U CN 220685084 U CN220685084 U CN 220685084U CN 202322294450 U CN202322294450 U CN 202322294450U CN 220685084 U CN220685084 U CN 220685084U
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- 239000006228 supernatant Substances 0.000 title claims abstract description 49
- 210000001808 exosome Anatomy 0.000 title claims abstract description 40
- 238000005119 centrifugation Methods 0.000 claims abstract description 21
- 210000004027 cell Anatomy 0.000 claims abstract description 12
- 239000012530 fluid Substances 0.000 claims abstract description 8
- 239000012528 membrane Substances 0.000 claims description 14
- 239000012535 impurity Substances 0.000 claims description 7
- 238000000926 separation method Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 4
- 230000006978 adaptation Effects 0.000 claims 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 abstract description 4
- 235000017491 Bambusa tulda Nutrition 0.000 abstract description 4
- 241001330002 Bambuseae Species 0.000 abstract description 4
- 235000015334 Phyllostachys viridis Nutrition 0.000 abstract description 4
- 239000011425 bamboo Substances 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 238000000605 extraction Methods 0.000 abstract description 2
- 238000009434 installation Methods 0.000 description 6
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000000746 purification Methods 0.000 description 3
- 238000005199 ultracentrifugation Methods 0.000 description 3
- 230000004075 alteration Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000023402 cell communication Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
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- Centrifugal Separators (AREA)
Abstract
The utility model provides a device for separating and purifying exosomes from supernatant fluid, and belongs to the technical field of exosome extraction. Including the mount table, the rotation is provided with first centrifugal tube on the mount table, first centrifugal tube top is equipped with the opening, the bottom is provided with a plurality of first filters, first centrifugal tube bottom still is connected with the collection box, be equipped with the second centrifugal tube in the first centrifugal tube, be equipped with the mounting bracket on the mount table, vertical sliding connection has the installing frame on the mounting bracket, and second driving motor fixed connection is on the installing frame, be equipped with in the mounting bracket and be used for driving the lifting unit that the installing frame slided along vertical direction, the position that is close to the bottom on the second centrifugal tube lateral wall is equipped with a plurality of second filters along circumference. In this application embodiment, cell supernatant can separate the exosome after the centrifugation of second centrifugation section of thick bamboo and first centrifugation section of thick bamboo in proper order, has convenient operation, improves production efficiency's effect.
Description
Technical Field
The utility model relates to the technical field of exosome extraction, in particular to a device for separating and purifying exosomes from supernatant.
Background
Exosomes refer to small vesicles comprising complex RNAs and proteins, which nowadays are in particular disc vesicles 40-100nm in diameter. The exosomes can be secreted by various cells under normal and pathological states, and the exosomes have wide application prospects in the aspects of cell communication, cell migration, tissue repair promotion or immune response regulation, etc., and the exosomes are separated and purified from supernatant, which is always a precondition for development and application research.
The ultracentrifugation method is a common way for separating and purifying exosomes, and the current separation and purification way mainly depends on manual operation, cell supernatant is poured into a centrifuge tube, the centrifuge tube is placed into the centrifuge for centrifugal separation, supernatant in the centrifuge tube is transferred into another centrifuge tube for ultracentrifugation after separation is completed, and the supernatant is poured out after ultracentrifugation is completed, so that the separated exosomes can be obtained. However, the operation mode needs frequent taking and placing of the centrifuge tube by a worker, and the exosome can be taken out only by manually pouring the supernatant, so that the problems of more operation steps and low production efficiency exist.
Disclosure of Invention
In view of the above, the present utility model provides a device for separating and purifying exosomes from a supernatant.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
the utility model provides a separate and purification exosome's device from supernatant, including the mount table, the rotation is provided with first centrifugal tube on the mount table, be equipped with in the mount table and be used for driving first centrifugal tube axial pivoted first driving motor, first centrifugal tube top is equipped with the opening, the bottom is provided with a plurality of first filters, first filter is used for filtering the exosome that separates in the supernatant after first centrifugal tube centrifugation, first centrifugal tube bottom still is connected with the collecting box that is used for collecting the supernatant after the centrifugation, be equipped with the second centrifugal tube in the first centrifugal tube, second centrifugal tube top is equipped with and is used for driving self pivoted second driving motor, be equipped with the mounting bracket on the mount table, vertical sliding connection has the installing frame on the installing frame, and second driving motor fixed connection is on the installing frame, be equipped with the lifting unit who is used for driving the installing frame to slide along vertical direction in the mounting bracket, the position that is close to the bottom on the second centrifugal tube lateral wall is equipped with a plurality of second filters along circumference, the second filter is used for filtering the sediment impurity that separates in the cell supernatant after the centrifugation of second centrifugal tube.
Further, the lifting assembly comprises a screw rod, the screw rod is vertically arranged in the installation frame in a rotating mode, a third driving motor for driving the screw rod to axially rotate is arranged on the installation frame, screw nuts are connected to the screw rod in a threaded mode, the outer wall of each screw nut is fixedly connected with the installation frame, and a limiting assembly for limiting the installation frame to horizontally rotate is further arranged on the installation frame.
Further, the limiting assembly comprises at least two limiting plates, the two limiting plates are vertically and symmetrically arranged on two sides of the screw rod, the limiting plates are fixedly connected with the mounting frame, the mounting frame is located between the two limiting plates, and the side wall of the mounting frame is in sliding contact with the two limiting plates.
Further, the end cover is detachably connected to the top of the first centrifugal barrel, one side, close to the first centrifugal barrel, of the end cover is provided with a limiting ring with the inner diameter and the first centrifugal barrel, the end cover comprises two symmetrically arranged sub-covers, and a driving assembly used for driving the two sub-covers to horizontally slide and splice to seal the top of the first centrifugal barrel is arranged on the mounting table.
Further, the driving assembly comprises two mounting plates and two air cylinders, the two mounting plates are symmetrically arranged on two sides of the first centrifugal cylinder and fixedly connected with the mounting table, the air cylinders are fixedly arranged on one side, close to the first centrifugal cylinder, of the mounting plates, the piston rods of the air cylinders face the first centrifugal cylinder, and the piston rods of the air cylinders are fixedly connected with the corresponding sub-covers.
Further, the first filter includes first filter membrane and first sleeve, and first filter membrane inlays and establishes in first sleeve, and first sleeve can dismantle the connection in first centrifugal section of thick bamboo bottom, and the second filter includes second filter membrane and second sleeve, and the second filter membrane inlays and establishes in the second sleeve, and the second sleeve can dismantle with the second centrifugal section of thick bamboo and be connected.
The beneficial effects of the utility model are as follows: the second centrifugal barrel is driven to rotate by the second driving motor to centrifuge cell supernatant once and separate out precipitated impurities, the centrifuged supernatant is discharged into the first centrifugal barrel, the first centrifugal barrel is driven to rotate by the first driving motor to perform secondary centrifugation on the supernatant after primary centrifugation and separate exosomes, the supernatant after secondary centrifugation is discharged into a collecting box below, and the exosomes separated by secondary centrifugation are remained at the inner bottom wall of the first centrifugal barrel, so that the centrifugal device has the effects of convenient operation and high production efficiency.
Drawings
FIG. 1 is a schematic diagram showing the overall structure of an apparatus for separating and purifying exosomes from a supernatant according to an embodiment of the present application.
FIG. 2 is a schematic diagram of the operation of a first centrifuge bowl for separating and purifying exosomes from supernatant according to an embodiment of the present application.
FIG. 3 is an exploded view of a first centrifuge bowl and collection box for separating and purifying exosomes from supernatant according to one embodiment of the present application.
Fig. 4 is an enlarged partial schematic view of the portion a in fig. 2.
FIG. 5 is a schematic cross-sectional view of a first filter and a second filter for separating and purifying exosomes from the supernatant according to an embodiment of the present application.
1, an installation table; 2. a first centrifuge bowl; 21. a first driving motor; 22. a first filter; 221. a first filter membrane; 222. a first sleeve; 23. a collection box; 3. a second centrifuge bowl; 31. a second driving motor; 32. a bearing bracket; 33. a second filter; 331. a second filter membrane; 332. a second sleeve; 4. a mounting frame; 5. a mounting frame; 6. a lifting assembly; 61. a screw rod; 62. a third driving motor; 7. a limit component; 71. a limiting plate; 8. an end cap; 81. a limiting ring; 82. dividing the cover; 9. a drive assembly; 91. a mounting plate; 92. and (3) a cylinder.
Detailed Description
In order to better understand the above technical solutions, the following detailed description will refer to the accompanying drawings and specific embodiments.
The embodiment of the application discloses device of separation and purification exosome in follow supernatant, refer to fig. 1, fig. 2 and fig. 3, including mount table 1, rotate on the mount table 1 and be provided with first centrifugal tube 2, first centrifugal tube 2 top is equipped with the opening, bottom installs a plurality of first filters 22, and first centrifugal tube 2 bottom still bolted connection has collection box 23. The first driving motor 21 is connected with the inside of the mounting table 1 through bolts, and the rotating shaft of the first driving motor 21 vertically upwards penetrates out of the top of the mounting table 1 and is connected with the collecting box 23 above through bolts. A second centrifugal cylinder 3 is arranged in the first centrifugal cylinder 2, and a second driving motor 31 for driving the second centrifugal cylinder 3 to rotate and a feeding pipe for injecting cell supernatant are arranged at the top of the second centrifugal cylinder. The mounting frame 4 is connected to the mounting table 1 through bolts, the mounting frame 5 is connected to the mounting frame 4 through vertical sliding connection, and the second driving motor 31 is connected to the mounting frame 5 through bolts. A lifting assembly 6 for driving the mounting frame 5 to slide along the vertical direction is arranged in the mounting frame 4. A plurality of second filters 33 are circumferentially mounted on the side wall of the second centrifugal cylinder 3 at a position near the bottom.
In the embodiment of the application, the lifting assembly 6 drives the mounting frame 5 to descend so as to drive the second centrifugal barrel 3 to descend into the first centrifugal barrel 2; then, the second driving motor 31 is started to drive the second centrifugal cylinder 3 to rotate so as to separate out precipitated impurities after the cell supernatant is subjected to one-time centrifugation, the separated supernatant is discharged into the first centrifugal cylinder 2 through the second filter 33, and the precipitated impurities are remained in the second centrifugal cylinder 3; finally, the first driving motor 21 is started to drive the first centrifugal barrel 2 to rotate, so that the supernatant fluid after the primary centrifugation is subjected to secondary centrifugation and the exosomes are separated, the supernatant fluid after the secondary centrifugation can be discharged into the collecting box 23 through the first filter 22, and the separated exosomes are reserved in the first centrifugal barrel 2.
In order to avoid the second centrifugal barrel from being too heavy to influence the rotation of the second driving motor 31, the mounting frame 5 is also connected with a bearing bracket 32 for supporting the second centrifugal barrel 3 by bolts. The central position of the bottom of the second centrifugal barrel 3 is provided with a groove, and one end of the bearing bracket 32 far away from the mounting frame 5 is inserted into the groove and enables the second centrifugal barrel 3 to rotate relative to the bearing bracket 32.
The lifting assembly 6 comprises a screw rod 61, the screw rod 61 is vertically and rotatably arranged in the mounting frame 4, a third driving motor 62 is connected to the mounting frame 4 through bolts, and a rotating shaft of the third driving motor 62 is connected with one end of the screw rod 61 through bolts. A screw nut (not shown in the figure) is screwed to the screw 61, and the outer wall of the screw nut is welded to the mounting frame 5. The third driving motor 62 drives the screw rod 61 to rotate so that the mounting frame 5 on the screw rod nut vertically slides, and the second centrifugal barrel 3 is driven to vertically lift and fall to enter and exit the first centrifugal barrel 2. The mounting frame 4 is also provided with a limiting component 7 for limiting the horizontal rotation of the mounting frame 5.
Referring to fig. 4, the limiting assembly 7 includes at least two limiting plates 71, the two limiting plates 71 are vertically and symmetrically disposed at both sides of the screw 61, and the limiting plates 71 are welded with the mounting frame 4. The mounting frame 5 is located between the two limiting plates 71, and the mounting frame 5 is in sliding contact with the limiting plates 71. When the third driving motor 62 drives the screw 61 to rotate to lift the screw nut, the mounting frame 5 on the screw nut is in sliding contact with the limiting plate 71 to limit the horizontal rotation of the mounting frame 5.
The top of the first centrifugal barrel 2 is detachably connected with an end cover 8, and one side of the end cover 8 close to the first centrifugal barrel 2 is integrally fixedly provided with a limiting ring 81 with an inner diameter size matched with the first centrifugal barrel 2. The end cover 8 comprises two symmetrically arranged sub covers 82, and the mounting table 1 is provided with a driving assembly 9 for driving the two sub covers 82 to slide horizontally and splice to seal the top of the first centrifugal barrel 2. After the second centrifugal barrel 3 completes centrifugal separation of cell supernatant, the second centrifugal barrel 3 can be driven to ascend and move out of the first centrifugal barrel 2 through the lifting assembly 6, then the driving assembly 9 is started to enable the sub-cover 82 at the top of the first centrifugal barrel 2 to horizontally slide and splice to form an integral end cover 8, and meanwhile the inner side wall of the limiting ring 81 is abutted with the outer side wall of the first centrifugal barrel 2.
The driving assembly 9 comprises two mounting plates 91 and two air cylinders 92, wherein the two mounting plates 91 are symmetrically arranged on two sides of the first centrifugal barrel 2 and are connected with the mounting table 1 through bolts. The cylinder 92 is bolted to the side of the mounting plate 91 near the first centrifugal cylinder 2, and the piston rod of the cylinder 92 faces the first centrifugal cylinder 2, and the piston rod of the cylinder 92 is also bolted to the corresponding sub-cover 82. The corresponding partial caps 82 are simultaneously urged toward the first centrifuge bowl 2 in the middle by two air cylinders 92 so that the partial caps 82 are combined to form the integral end cap 8.
Referring to fig. 5, the first filter 22 includes a first filter membrane 221 and a first sleeve 222, the first filter membrane 221 is embedded in the first sleeve 222, a plurality of first threaded holes with the diameter matching with the first sleeve 222 are formed in the bottom of the first centrifugal barrel 2, and the first sleeve 222 is in threaded connection with the first threaded holes. The second filter 33 comprises a second filter membrane 331 and a second sleeve 332, the second filter membrane 331 is embedded in the second sleeve 332, a plurality of second threaded holes matched with the diameter of the second sleeve 332 are formed in the position, close to the bottom, of the side wall of the second centrifugal barrel 3, and the second sleeve 332 is in threaded connection with the second threaded holes. The cell supernatant centrifuged in the second centrifuge tube 3 is discharged into the first centrifuge tube 2 through the second filter 331, and the separated precipitated impurities are blocked in the second centrifuge tube 3 by the second filter 331. The supernatant after the secondary centrifugation in the first centrifuge bowl 2 is discharged to the lower collection box 23 through the first filter 221, and the exosomes separated after the secondary centrifugation are blocked in the second centrifuge bowl 2 by the first filter 221.
The device for separating and purifying exosomes from the supernatant according to the embodiment of the application is implemented by the following principle: in the use process of a device for separating and purifying exosomes from supernatant, cell supernatant is poured into a second centrifugal cylinder 3, the second centrifugal cylinder 3 is driven to rotate by a second driving motor 31 to perform primary centrifugation on the cell supernatant and separate sediment impurities, the centrifuged supernatant is discharged into a first centrifugal cylinder 2 through a second filter 33, then the second centrifugal cylinder 3 is driven to ascend and move out of the first centrifugal cylinder 2 through a lifting assembly 6, a separating cover 82 is combined into an integral end cover 8 by starting the driving assembly 9 to seal an opening at the top of the first centrifugal cylinder 2, then the first driving motor 21 is started to drive the first centrifugal cylinder 2 to perform secondary centrifugation on the supernatant discharged into the first centrifugal cylinder 2 and separate exosomes, the supernatant after the secondary centrifugation is discharged into a collecting box 23 below through the first filter 22, and the exosomes separated by the secondary centrifugation are reserved in the bottom wall of the first centrifugal cylinder 2. Compared with the traditional way of separating and purifying exosomes, the device for separating and purifying exosomes from supernatant in the embodiment of the application reduces the steps of manual operation and has the effects of convenient operation and high production efficiency.
It will be apparent to those skilled in the art that while preferred embodiments of the present utility model have been described, additional variations and modifications may be made to these embodiments once the basic inventive concepts are known to those skilled in the art. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the utility model. It will be apparent to those skilled in the art that various modifications and variations can be made to the present utility model without departing from the spirit or scope of the utility model. Thus, it is intended that the present utility model also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (6)
1. A device for separating and purifying exosomes from a supernatant fluid, characterized in that: including mount table (1), rotate on mount table (1) and be provided with first centrifugal tube (2), be equipped with in mount table (1) and be used for driving first centrifugal tube (2) axial pivoted first driving motor (21), first centrifugal tube (2) top is equipped with the opening, the bottom is provided with a plurality of first filters (22), first filter (22) are arranged in filtering the exosome that separates in the supernatant after first centrifugal tube (2) centrifugation, first centrifugal tube (2) bottom still is connected with collection box (23) that are used for collecting the supernatant after the centrifugal separation, be equipped with second centrifugal tube (3) in first centrifugal tube (2), second centrifugal tube (3) top is equipped with second driving motor (31) that are used for driving self pivoted, be equipped with mounting bracket (4) on mount table (1), vertical sliding connection has installing frame (5) on mounting bracket (4), and second driving motor (31) fixed connection is on installing frame (5), be equipped with in installing frame (4) and be used for driving down the second filter (6) along the vertical slip of circumference of a plurality of filter (6) and be equipped with along second lateral wall (33) of circumference direction of the filter (6), the second filter (33) is used for filtering the precipitated impurities separated from the cell supernatant after being centrifuged by the second centrifugal barrel (3).
2. An apparatus for separating and purifying exosomes from supernatant fluid according to claim 1, characterized in that: lifting assembly (6) are including lead screw (61), the vertical rotation setting of lead screw (61) is in mounting bracket (4), be equipped with on mounting bracket (4) and be used for driving lead screw (61) axial pivoted third driving motor (62), threaded connection has screw-nut on lead screw (61), and screw-nut's outer wall and installing frame (5) fixed connection, still be equipped with on mounting bracket (4) and be used for restricting installing frame (5) horizontal pivoted spacing subassembly (7).
3. An apparatus for separating and purifying exosomes from supernatant fluid according to claim 2, characterized in that: the limiting assembly (7) comprises at least two limiting plates (71), the two limiting plates (71) are vertically symmetrically arranged on two sides of the screw rod (61), the limiting plates (71) are fixedly connected with the mounting frame (4), the mounting frame (5) is located between the two limiting plates (71), and the side wall of the mounting frame (5) is in sliding contact with the two limiting plates (71).
4. An apparatus for separating and purifying exosomes from supernatant fluid according to claim 1, characterized in that: the utility model discloses a centrifugal machine, including a centrifugal barrel (2), an end cover (8) is detachably connected with at the top of the centrifugal barrel (2), and one side that the end cover (8) is close to the centrifugal barrel (2) is equipped with spacing ring (81) of internal diameter size and the adaptation of the centrifugal barrel (2), the end cover (8) includes two branch covers (82) that the symmetry set up, be equipped with on mount table (1) and be used for driving two branch covers (82) level to slide and splice in order to seal drive assembly (9) at the top of the centrifugal barrel (2).
5. The apparatus for separating and purifying exosomes from the supernatant of claim 4, wherein: the driving assembly (9) comprises two mounting plates (91) and two air cylinders (92), the two mounting plates (91) are symmetrically arranged on two sides of the first centrifugal cylinder (2) and fixedly connected with the mounting table (1), the air cylinders (92) are fixedly arranged on one side, close to the first centrifugal cylinder (2), of the mounting plates (91), piston rods of the air cylinders (92) face the first centrifugal cylinder (2), and piston rods of the air cylinders (92) are fixedly connected with corresponding sub-covers (82).
6. An apparatus for separating and purifying exosomes from supernatant fluid according to any one of claims 1-5, characterized in that: the first filter (22) comprises a first filter membrane (221) and a first sleeve (222), the first filter membrane (221) is embedded in the first sleeve (222), the first sleeve (222) is detachably connected to the bottom of the first centrifugal barrel (2), the second filter (33) comprises a second filter membrane (331) and a second sleeve (332), the second filter membrane (331) is embedded in the second sleeve (332), and the second sleeve (332) is detachably connected with the second centrifugal barrel (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322294450.3U CN220685084U (en) | 2023-08-25 | 2023-08-25 | Device for separating and purifying exosomes from supernatant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322294450.3U CN220685084U (en) | 2023-08-25 | 2023-08-25 | Device for separating and purifying exosomes from supernatant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220685084U true CN220685084U (en) | 2024-03-29 |
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ID=90405558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322294450.3U Active CN220685084U (en) | 2023-08-25 | 2023-08-25 | Device for separating and purifying exosomes from supernatant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220685084U (en) |
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2023
- 2023-08-25 CN CN202322294450.3U patent/CN220685084U/en active Active
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