CN220685085U - Exosome separator - Google Patents
Exosome separator Download PDFInfo
- Publication number
- CN220685085U CN220685085U CN202322294667.4U CN202322294667U CN220685085U CN 220685085 U CN220685085 U CN 220685085U CN 202322294667 U CN202322294667 U CN 202322294667U CN 220685085 U CN220685085 U CN 220685085U
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- centrifugal barrel
- pipe
- annular baffle
- exosome
- centrifugation bucket
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- 210000001808 exosome Anatomy 0.000 title claims abstract description 45
- 239000006228 supernatant Substances 0.000 claims abstract description 34
- 238000005119 centrifugation Methods 0.000 claims abstract description 26
- 238000000926 separation method Methods 0.000 claims abstract description 15
- 210000004027 cell Anatomy 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 238000005086 pumping Methods 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 12
- 238000013329 compounding Methods 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 2
- 238000010168 coupling process Methods 0.000 claims description 2
- 238000005859 coupling reaction Methods 0.000 claims description 2
- 239000013049 sediment Substances 0.000 claims description 2
- 238000000605 extraction Methods 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 9
- 239000002953 phosphate buffered saline Substances 0.000 description 9
- 239000012535 impurity Substances 0.000 description 5
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 3
- 238000005199 ultracentrifugation Methods 0.000 description 3
- 230000004075 alteration Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 206010064390 Tumour invasion Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000030741 antigen processing and presentation Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000009400 cancer invasion Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Abstract
The utility model provides an exosome separation device, and belongs to the technical field of exosome extraction. Including the mount pad, rotate on the mount pad and be connected with first centrifugal barrel and second centrifugal barrel, first centrifugal barrel top is equipped with the connecting pipe, the connecting pipe is kept away from the top of second centrifugal barrel of one end connection of first centrifugal barrel, the connecting pipe is close to first centrifugal barrel one end and is established to vertical section, and be connected with flexible pipe in the vertical section, be equipped with on the mount pad and be used for driving flexible pipe bottom to stretch into/stretch out first lifting assembly of first centrifugal barrel, second centrifugal barrel top still is equipped with material extraction pipe and inlet pipe, be equipped with the mounting bracket on the mount pad, and be equipped with on the mounting bracket and be used for driving material extraction pipe along the gliding second lifting assembly of vertical direction. In this application embodiment, cell supernatant can separate the exosome in the supernatant after first centrifuge barrel and second centrifuge barrel centrifugation in proper order, has convenient operation, improves production efficiency's effect.
Description
Technical Field
The utility model relates to the technical field of exosome extraction, in particular to an exosome separation device.
Background
The exosomes refer to small membrane vesicles containing complex RNA and protein, and various cells can secrete the exosomes under normal and pathological states, and the extracted exosomes can be applied to medical researches such as organism immune response, antigen presentation, cell migration, cell differentiation, tumor invasion and the like.
Ultracentrifugation is a common exosome extraction method by first collecting the cultured cell supernatant into a centrifuge tube, then placing it into a centrifuge for centrifugation pretreatment, and transferring the separated cell supernatant to another centrifuge tube through a sterile filter after centrifugation is completed. After pretreatment is completed, the collected supernatant is placed into a centrifugal machine again for ultracentrifugation, the supernatant is poured out after ultracentrifugation is completed, exosomes are attached to the inner bottom wall of a centrifugal tube, finally, the centrifugal tube is opened, sterile PBS (phosphate buffered saline) liquid is added into the centrifugal tube to dissolve the exosomes, and heavy suspension containing the exosomes can be collected after dissolution is completed.
However, the traditional extraction method requires manual operation to open the centrifuge for many times and carry out treatments such as filtration, transfer and the like on cell supernatant in the centrifuge tube, so that the operation steps are more, and the extraction efficiency on exosomes is low.
Disclosure of Invention
In view of the above, the present utility model provides an exosome separation device.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
the utility model provides an exosome separator, including the mount pad, it is connected with first centrifugal barrel and second centrifugal barrel to rotate on the mount pad, be equipped with in the mount pad and be used for driving first centrifugal barrel pivoted first driving motor and be used for driving second centrifugal barrel pivoted second driving motor, first centrifugal barrel top is equipped with the connecting pipe, the one end that first centrifugal barrel was kept away from to the connecting pipe is connected with the top of second centrifugal barrel, the connecting pipe is close to first centrifugal barrel one end and establishes to vertical section, and coaxial coupling has flexible pipe on the vertical section, be equipped with on the mount pad and be used for driving flexible pipe bottom to stretch into/stretch out the first lifting assembly of first centrifugal barrel, be equipped with first water pump on the connecting pipe, first centrifugal barrel is used for once centrifuging the cell supernatant in the first centrifugal barrel and separates out the sediment impurity, second centrifugal barrel top still is equipped with the suction pipe that is used for extracting the supernatant that obtains through once centrifugation in the second centrifugal barrel, and be used for pouring sterile PBS liquid after extracting supernatant, the second centrifugal barrel is arranged in the supernatant in the second centrifugal barrel and separate exosome, be equipped with the second water pump on the suction pipe, and be equipped with on the suction pipe, and install the mounting bracket and be used for the second lifting assembly to slide along the direction.
Further, the first lifting assembly comprises a cylinder, the cylinder is fixedly connected to the mounting seat, a piston rod of the cylinder is vertically upwards, and the piston rod of the cylinder is fixedly connected with the outer wall of the telescopic pipe.
Further, the second lifting assembly comprises a screw rod, the screw rod is vertically and rotatably connected in the mounting frame, a third driving motor for driving the screw rod to rotate is arranged on the mounting frame, a screw nut is connected to the screw rod in a threaded mode, a mounting plate is fixedly connected to the outer wall of the screw nut, a second water pump is fixedly connected to the mounting plate, and the material pumping pipe is a hard pipe and is fixedly connected with the second water pump.
Further, still be equipped with the compounding device on the mount pad, the compounding device includes gas-supply pipe and air-blower, and the one end of gas-supply pipe extends to diapire in the second centrifugation bucket, the other end and air-blower fixed connection, carries gas in order to make aseptic PBS liquid roll in the second centrifugation bucket through the air-blower to accelerate the speed of dissolving the exosome.
Further, the position on the side wall of the first centrifugal barrel, which is close to the top, is detachably connected with a first annular baffle along the circumferential direction, the inner ring of the first annular baffle is close to the inner wall of the first centrifugal barrel, so that the outer ring side of the first annular baffle is higher than the inner ring side of the first annular baffle in the vertical direction, the inner ring of the first annular baffle is just opposite to the telescopic pipe above, the position on the side wall of the second centrifugal barrel, which is close to the top, is detachably connected with a second annular baffle along the circumferential direction, the inner ring of the second annular baffle is close to the inner wall of the second centrifugal barrel, so that the outer ring side of the second annular baffle is higher than the inner ring side of the second annular baffle in the vertical direction, and the connecting pipe, the feeding pipe, the pumping pipe and the gas pipe all penetrate through the inner ring of the second annular baffle.
Further, the side walls of the first centrifugal barrel and the second centrifugal barrel are provided with observation windows.
The beneficial effects of the utility model are as follows: the supernatant liquid of the primary centrifugal cell can be rotated through the first centrifugal barrel and precipitated impurities are separated, the supernatant liquid after primary centrifugal separation is conveyed to the second centrifugal barrel to be subjected to secondary centrifugation so as to separate exosomes, the supernatant liquid after secondary centrifugation can be discharged through the pumping pipe, the exosomes separated by secondary centrifugation are remained in the second centrifugal barrel, sterile PBS liquid is poured into the second centrifugal barrel through the feeding pipe so as to dissolve and extract the exosomes, and the method has the effects of being convenient to operate and production efficiency.
Drawings
Fig. 1 is a schematic overall structure of an exosome separation device according to an embodiment of the present application.
Fig. 2 is a schematic view of another view structure of an exosome separation apparatus according to an embodiment of the present application.
Fig. 3 is a schematic diagram of the internal structure of a first centrifugal barrel of an exosome separation apparatus according to an embodiment of the present application.
1, a mounting seat; 2. a first centrifuge bowl; 21. a first driving motor; 3. a second centrifuge bowl; 31. a second driving motor; 4. a connecting pipe; 5. a telescopic tube; 6. a first lifting assembly; 61. a cylinder; 7. a first water pump; 8. a feed pipe; 9. a material pumping pipe; 91. a second water pump; 10. a mounting frame; 11. a second lifting assembly; 111. a screw rod; 112. a third driving motor; 113. a mounting plate; 12. a mixing device; 121. a gas pipe; 122. a blower; 13. a first annular baffle; 14. a second annular baffle; 15. and an observation window.
Detailed Description
In order to better understand the above technical solutions, the following detailed description will refer to the accompanying drawings and specific embodiments.
The embodiment of the application discloses exosome separator, refer to fig. 1, fig. 2 and fig. 3, including mount pad 1, rotate on mount pad 1 and be connected with first centrifugal barrel 2 and second centrifugal barrel 3, bolted connection has first driving motor 21 and second driving motor 31 in the mount pad 1. The rotation shaft of the first driving motor 21 vertically passes through the top of the mounting seat 1 upwards and is connected with the bottom of the first centrifugal barrel 2 through bolts, and the rotation shaft of the second driving motor 31 vertically passes through the top of the mounting seat 1 upwards and is connected with the bottom of the second centrifugal barrel 3 through bolts. The connecting pipe 4 is installed at the top of the first centrifugal barrel 2, and one end of the connecting pipe 4 far away from the first centrifugal barrel 2 is connected to the top of the second centrifugal barrel 3. One end of the connecting pipe 4, which is close to the first centrifugal barrel 2, is arranged as a vertical section, the vertical section is coaxially connected with the telescopic pipe 5, a first lifting assembly 6 for driving the bottom end of the telescopic pipe 5 to extend into/out of the first centrifugal barrel 2 is arranged on the mounting seat 1, and a first water pump 7 is also arranged on the connecting pipe 4. The cell supernatant is poured into the first centrifugal barrel 2, and the cell supernatant in the first centrifugal barrel 2 can be centrifuged once and precipitated impurities can be separated out by driving the first centrifugal barrel 2 to rotate through the first driving motor 21. The telescopic pipe 5 is driven to descend and extend into the first centrifugal barrel 2 through the first lifting assembly 6, and then the supernatant separated from the first centrifugal barrel 2 can be transported into the second centrifugal barrel 3 by starting the first water pump 7. The top of the second centrifugal barrel 3 is also provided with a pumping pipe 9, and the pumping pipe 9 is provided with a second water pump 91. The mounting seat 1 is connected with a mounting frame 10 through bolts, and a second lifting assembly 11 for driving the pumping pipe 9 and the water pump to slide along the vertical direction is mounted in the mounting frame 10. After the second centrifugal barrel 3 secondarily centrifiges the supernatant in the second centrifugal barrel 3 and separates the exosome, the pumping pipe 9 and the second water pump 91 can be driven to vertically descend by the second lifting assembly 11 to pump the secondarily centrifuged supernatant, and the exosome remains at the bottom wall of the second centrifugal barrel 3. The top of the second centrifugal barrel 3 is also provided with a feed pipe 8, and when the supernatant in the second centrifugal barrel 3 is extracted through the extraction pipe 9, the second centrifugal barrel 3 is filled with sterile PBS liquid through the feed pipe 8 to dissolve and extract exosomes.
Specifically, the first lifting assembly 6 includes a cylinder 61, the cylinder 61 is bolted to the mounting base 1, and a piston rod of the cylinder 61 is vertically upward. The top of the piston rod of the air cylinder 61 is connected with a connecting plate through bolts, and the connecting plate is connected with the outer wall of the telescopic pipe 5 through welding. The cylinder 61 drives the piston rod to vertically descend so as to drive the telescopic pipe 5 to descend and extend into the first centrifugal barrel 2.
The second lifting assembly 11 comprises a screw rod 111, the screw rod 111 is vertically and rotatably connected in the mounting frame 10, and a third driving motor 112 for driving the screw rod 111 to rotate is arranged on the mounting frame 10. A screw nut (not shown) is screwed on the screw 111, and a mounting plate 113 is welded on the outer wall of the screw nut. The second water pump 91 is connected to the mounting plate 113 by bolts, and the pumping pipe 9 is a hard pipe, and can be made of PVC or other materials. The third driving motor 112 drives the screw rod 111 to rotate so as to enable the second water pump 91 on the mounting plate 113 to descend, and accordingly the pumping pipe 9 is driven to extend into the second centrifugal barrel 3. The supernatant after the secondary centrifugation in the second centrifuge basket 3 is then pumped out by activating the second water pump 91, and the separated exosomes remain in the bottom wall of the second centrifuge basket 3.
The mounting seat 1 is also provided with a mixing device 12, and the mixing device 12 comprises a gas pipe 121 and a blower 122. One end of the air pipe 121 extends to the inner bottom wall of the second centrifugal barrel 3, and the other end is mounted on the blower 122. The speed of dissolving and extracting the exosomes by the sterile PBS solution can be increased by feeding the air into the second centrifuge basket 3 by the blower 122 to tumble the sterile PBS solution.
The position on the side wall of the first centrifugal barrel 2, which is close to the top, is connected with a first annular baffle 13 along the circumferential thread, the inner ring side of the first annular baffle 13 is close to the inner bottom wall of the first centrifugal barrel 2, so that the outer ring side of the first annular baffle 13 is higher than the inner ring side of the first annular baffle 13 in the vertical direction, and the inner ring of the first annular baffle 13 is opposite to the upper telescopic pipe 5. When the first lifting assembly 6 drives the telescopic tube 5 into the first centrifugal barrel 2, the telescopic tube 5 may pass through the inner ring of the first annular barrier 13. The position on the side wall of the second centrifugal barrel 3, which is close to the top, is also in threaded connection with a second annular baffle plate 14 along the circumferential direction, the inner ring side of the second annular baffle plate 14 is close to the inner bottom wall of the second centrifugal barrel 3, so that the outer ring side of the second annular baffle plate 14 is higher than the inner ring side of the second annular baffle plate 14 in the vertical direction, and the connecting pipe 4, the feeding pipe 8, the pumping pipe 9 and the gas pipe 121 all penetrate through the inner ring of the second annular baffle plate 14.
Transparent observation windows 15 are formed in the side walls of the first centrifugal barrel 2 and the second centrifugal barrel 3, and the corresponding working conditions of centrifugal separation in the first centrifugal barrel 2 and the second centrifugal barrel 3 can be observed in real time through the observation windows 15. When the supernatant liquid in the first centrifugal barrel 2/the second centrifugal barrel 3 is extracted, the extraction condition of the supernatant liquid can be observed in real time through the observation window 15, so that the extraction of the precipitated impurities/exosomes is avoided.
The implementation principle of the exosome separation device in the embodiment of the application is as follows: in the use process of the exosome separating device, cell supernatant is poured into the first centrifugal barrel 2, the cell supernatant can be centrifuged once through the rotation of the first centrifugal barrel 2 and precipitated impurities are separated, then the telescopic pipe 5 can be stretched into the first centrifugal barrel 2 through the first lifting component 6, the supernatant after centrifugal separation in the first centrifugal barrel 2 can be conveyed to the second centrifugal barrel 3 by starting the first water pump 7, the supernatant after primary centrifugation can be centrifuged again by starting the second centrifugal barrel 3 to obtain exosomes, the supernatant after secondary centrifugation can be discharged through the pumping pipe 9, and the exosomes after secondary centrifugation can be dissolved through pouring sterile PBS liquid through the feeding pipe 8, so that staff can extract the exosomes. Not only reduces the steps of manual operation, but also has the effect of improving the production efficiency.
It will be apparent to those skilled in the art that while preferred embodiments of the present utility model have been described, additional variations and modifications may be made to these embodiments once the basic inventive concepts are known to those skilled in the art. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the utility model. It will be apparent to those skilled in the art that various modifications and variations can be made to the present utility model without departing from the spirit or scope of the utility model. Thus, it is intended that the present utility model also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (6)
1. An exosome separator, its characterized in that: including mount pad (1), it is connected with first centrifugation bucket (2) and second centrifugation bucket (3) to rotate on mount pad (1), be equipped with in mount pad (1) be used for driving first centrifugation bucket (2) pivoted first driving motor (21) and be used for driving second centrifugation bucket (3) pivoted second driving motor (31), first centrifugation bucket (2) top is equipped with connecting pipe (4), the one end that first centrifugation bucket (2) was kept away from to connecting pipe (4) is connected the top of second centrifugation bucket (3), connecting pipe (4) are close to first centrifugation bucket (2) one end and are established to vertical section, and coaxial coupling has flexible pipe (5) on the vertical section, be equipped with on mount pad (1) be used for driving flexible pipe (5) bottom to stretch into/stretch out first centrifugation bucket (2) first lifting assembly (6), be equipped with first water pump (7) on connecting pipe (4), first centrifugation bucket (2) are used for once centrifuging in first centrifugation bucket (2) cell supernatant and separating out, second centrifugation bucket (3) are equipped with the aseptic sediment supernatant that is used for extracting supernatant in second centrifugation bucket (3) and is equipped with in the top of supernatant (8) and is used for extracting supernatant (8), the second centrifugal barrel (3) is used for separating an exosome from supernatant in the second centrifugal barrel (3), a second water pump (91) is arranged on the pumping pipe (9), a mounting frame (10) is arranged on the mounting seat (1), and a second lifting assembly (11) for driving the pumping pipe (9) and the water pump to slide along the vertical direction is arranged on the mounting frame (10).
2. An exosome separation apparatus according to claim 1, wherein: the first lifting assembly (6) comprises an air cylinder (61), the air cylinder (61) is fixedly connected to the mounting seat (1), a piston rod of the air cylinder (61) is vertically upwards, and the piston rod of the air cylinder (61) is fixedly connected with the outer wall of the telescopic pipe (5).
3. An exosome separation apparatus according to claim 1, wherein: the second lifting assembly (11) comprises a screw rod (111), the screw rod (111) is vertically and rotatably connected in the mounting frame (10), a third driving motor (112) for driving the screw rod (111) to rotate is arranged on the mounting frame (10), a screw nut is connected to the screw rod (111) in a threaded mode, a mounting plate (113) is fixedly connected to the outer wall of the screw nut, a second water pump (91) is fixedly connected to the mounting plate (113), and the material pumping pipe (9) is a hard pipe and is fixedly connected with the second water pump (91).
4. An exosome separation apparatus according to claim 1, wherein: still be equipped with compounding device (12) on mount pad (1), compounding device (12) are including gas-supply pipe (121) and air-blower (122), the one end of gas-supply pipe (121) extends to diapire in second centrifugal barrel (3), the other end and air-blower (122) fixed connection, through air-blower (122) are gaseous in to second centrifugal barrel (3) in order to make aseptic PBS liquid roll to accelerate the speed of dissolving the exosome.
5. An exosome separation apparatus according to claim 4, wherein: the utility model discloses a centrifugal barrel, including centrifugal barrel, first centrifugal barrel (2), second centrifugal barrel (3), first annular baffle (13) are connected with along circumference dismantlement in the position that is close to the top on first centrifugal barrel (2) lateral wall, the inner ring side of first annular baffle (13) is close to first centrifugal barrel (2) inner wall for the outer loop side of first annular baffle (13) is higher than first annular baffle (13) inner ring side in the vertical direction, the inner ring of first annular baffle (13) just is to flexible pipe (5) above, be close to top on second centrifugal barrel (3) lateral wall and be connected with second annular baffle (14) along circumference dismantlement, the inner ring side of second annular baffle (14) is close to second centrifugal barrel (3) inner wall for the outer loop side of second annular baffle (14) is higher than second annular baffle (14) inner ring side in the vertical direction, connecting pipe (4), inlet pipe (8), pump material pipe (9) and gas-supply pipe (121) all pass second annular baffle (14) inner ring.
6. An exosome separation apparatus according to any one of claims 1 to 5, wherein: the side walls of the first centrifugal barrel (2) and the second centrifugal barrel (3) are provided with observation windows (15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322294667.4U CN220685085U (en) | 2023-08-25 | 2023-08-25 | Exosome separator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322294667.4U CN220685085U (en) | 2023-08-25 | 2023-08-25 | Exosome separator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220685085U true CN220685085U (en) | 2024-03-29 |
Family
ID=90376540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322294667.4U Active CN220685085U (en) | 2023-08-25 | 2023-08-25 | Exosome separator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220685085U (en) |
-
2023
- 2023-08-25 CN CN202322294667.4U patent/CN220685085U/en active Active
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