CN220376646U - Cross-linked sodium hyaluronate gel incubator for injection - Google Patents
Cross-linked sodium hyaluronate gel incubator for injection Download PDFInfo
- Publication number
- CN220376646U CN220376646U CN202321863176.0U CN202321863176U CN220376646U CN 220376646 U CN220376646 U CN 220376646U CN 202321863176 U CN202321863176 U CN 202321863176U CN 220376646 U CN220376646 U CN 220376646U
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- box
- fixed
- incubator
- sodium hyaluronate
- driving motor
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- 229920002385 Sodium hyaluronate Polymers 0.000 title claims abstract description 30
- 229940010747 sodium hyaluronate Drugs 0.000 title claims abstract description 30
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 title claims abstract description 30
- 238000002347 injection Methods 0.000 title claims abstract description 24
- 239000007924 injection Substances 0.000 title claims abstract description 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 56
- 239000007788 liquid Substances 0.000 claims abstract description 48
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 28
- 238000001816 cooling Methods 0.000 claims abstract description 25
- 230000005540 biological transmission Effects 0.000 claims abstract description 19
- 238000009423 ventilation Methods 0.000 claims abstract description 16
- 238000007789 sealing Methods 0.000 claims description 4
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 description 5
- 244000005700 microbiome Species 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model relates to the technical field of sodium hyaluronate gel processing equipment, in particular to a cross-linked sodium hyaluronate gel incubator for injection. Its technical scheme includes the box, is fixed in the driving motor of box bottom surface one end, rotates the drive carousel of connecting in the inside both sides of box, drive carousel bottom is connected with the driving motor transmission, drive carousel top is connected with the culture dish, still includes: the cooling box is arranged on one side of the inner part of the box body, the middle part of the inner side of the cooling box is rotationally connected with a ventilation blade, and the ventilation blade is in transmission connection with the driving motor; the cover plate is covered on the top surface of the box body, a liquid nitrogen box is fixed in the cover plate, a control valve is fixed on one side of the liquid nitrogen box, a liquid outlet pipe penetrates through the inner side of the control valve, and two ends of the liquid outlet pipe are respectively communicated with the liquid nitrogen box and the inner side of the cooling box; the utility model can keep the culture temperature of the strain at any time, thereby improving the culture quality of the strain and leading the practicability of the device to be stronger.
Description
Technical Field
The utility model relates to the technical field of sodium hyaluronate gel processing equipment, in particular to a cross-linked sodium hyaluronate gel incubator for injection.
Background
The sodium hyaluronate gel is also called hyaluronic acid, and mainly comprises sodium hyaluronate, and auxiliary materials of disodium hydrogen phosphate and monopotassium phosphate, wherein the sodium hyaluronate can be used for medical auxiliary use, can be smeared on the surface of an operation opening for recovering wound in ophthalmic operation, orthopedic operation and gynecological operation, the production of the sodium hyaluronate gel is divided into natural and artificial modes, the artificial production is divided into a microorganism fermentation method and an animal tissue extraction method, and the microorganism fermentation method needs to use a culture vessel for fermenting and culturing microorganisms in an environment of 2-8 degrees.
The Chinese patent of 201921328929.1 discloses a sodium hyaluronate strain incubator, which is internally provided with a shaking placing tray, so that the applicability of strain culture is improved, but a low-temperature device is not arranged in the incubator, and the incubator cannot keep the culture temperature of sodium hyaluronate gel strain in the incubator only by adopting a constant temperature blown by a fan from the outside.
Therefore, there is a need for improvements in cross-linked sodium hyaluronate gel incubators for injection.
Disclosure of Invention
The utility model aims at solving the problems in the background technology, and provides a cross-linked sodium hyaluronate gel incubator for injection, which is used for solving the problem that the interior of the incubator cannot be cooled, so that the incubator can keep the applicable temperature of low temperature for culturing sodium hyaluronate strains.
The technical scheme of the utility model is as follows: the utility model provides a cross-linked sodium hyaluronate gel incubator for injection, includes the box, is fixed in the driving motor of box bottom surface one end, rotates the drive carousel of connecting in the inside both sides of box, the drive carousel bottom is connected with the driving motor transmission, the drive carousel top is connected with the culture dish, still includes:
the cooling box is arranged on one side of the inner part of the box body, the middle part of the inner side of the cooling box is rotationally connected with a ventilation blade, and the ventilation blade is in transmission connection with the driving motor;
the liquid nitrogen box is characterized by comprising a cover plate, wherein the cover plate covers the top surface of the box body, a liquid nitrogen box is fixed inside the cover plate, a control valve is fixed on one side of the liquid nitrogen box, a liquid outlet pipe is arranged on the inner side of the control valve in a penetrating mode, and two ends of the liquid outlet pipe are respectively communicated with the liquid nitrogen box and the inner side of the cooling box.
Preferably, the driving motor driving end is fixed with the pivot, the position fixing that driving turntable and driving motor transmission are connected has bevel gear and driving motor meshing transmission to be connected, the one end that driving motor was kept away from to the pivot is fixed with the belt pulley, the belt pulley outside cover is fit with the drive belt, the drive belt other end cover is fit with in ventilation vane one end outer wall.
Preferably, one side of the top surface of the cover plate is fixed with a thermometer, and the bottom of the thermometer is communicated with the inner side of the box body.
Preferably, one end of the thermometer connected with the inside of the box body is fixed with a temperature detector, and the temperature detector is electrically connected with the thermometer.
Preferably, the top surface of the control valve is fixed with an adjusting rotating wheel, and the other end of the adjusting rotating wheel is positioned outside the top surface of the cover plate.
Preferably, a liquid injection port is formed in one side of the outer wall of the liquid nitrogen box, and a sealing cover is screwed on the outer side of the liquid injection port.
Preferably, a second bevel gear is fixed at the position where the rotating shaft is connected with the bevel gear, and the second bevel gear is in transmission connection with the bevel gear.
Compared with the prior art, the utility model has the following beneficial technical effects:
according to the utility model, the cooling box is arranged on one side of the box body and is communicated with the interior of the box body, and the ventilation blades are arranged in the cooling box to convey air to the interior of the box body, so that liquid nitrogen at the top of the cover plate can convey low temperature generated in the cooling box to the interior of the box body, and therefore, when the device is used for culturing the sodium hyaluronate gel strain, the culture temperature of the strain can be kept at any time, the culture quality of the strain is improved, and the device is higher in practicability.
Drawings
FIG. 1 shows a schematic diagram of a cross-linked sodium hyaluronate gel incubator for injection according to the present utility model;
FIG. 2 is a schematic view of the middle section structure of FIG. 1;
FIG. 3 is an exploded view of the internal structure of FIG. 1;
fig. 4 is an enlarged schematic view of the internal structure of the cover plate of fig. 3.
Reference numerals: 1. a case; 2. a driving motor; 3. driving a turntable; 4. a culture tray; 5. a belt pulley; 6. a ventilation blade; 7. a cooling box; 8. a cover plate; 9. a liquid nitrogen box; 10. a control valve; 11. a liquid outlet pipe; 12. a thermometer; 13. a temperature detector; 14. adjusting the rotating wheel; 15. a liquid injection port; 16. sealing cover.
Detailed Description
The technical scheme of the utility model is further described below with reference to the attached drawings and specific embodiments.
Example 1
As shown in fig. 1-4, the cross-linked sodium hyaluronate gel incubator for injection provided by the utility model comprises a case body 1, a driving motor 2 fixed at one end of the bottom surface of the case body 1, and a driving turntable 3 rotatably connected to two sides inside the case body 1, wherein the bottom end of the driving turntable 3 is in transmission connection with the driving motor 2, and the top of the driving turntable 3 is connected with a culture dish 4, and the cross-linked sodium hyaluronate gel incubator further comprises:
the cooling box 7 is arranged on one side of the inside of the box body 1, the middle part of the inner side of the cooling box 7 is rotationally connected with a ventilation blade 6, and the ventilation blade 6 is in transmission connection with the driving motor 2;
the cover plate 8 is covered on the top surface of the box body 1, a liquid nitrogen box 9 is fixed in the cover plate 8, a control valve 10 is fixed on one side of the liquid nitrogen box 9, a liquid outlet pipe 11 penetrates through the inner side of the control valve 10, and two ends of the liquid outlet pipe 11 are respectively communicated with the liquid nitrogen box 9 and the inner side of the cooling box 7;
a rotating shaft is fixed at the transmission end of the driving motor 2, a bevel gear is fixed at the transmission connection position of the driving turntable 3 and the driving motor 2 and is in meshed transmission connection with the driving motor 2, a belt pulley 5 is fixed at one end of the rotating shaft far away from the driving motor 2, a transmission belt is sleeved outside the belt pulley 5, and the other end of the transmission belt is sleeved on the outer wall of one end of the ventilation blade 6;
an adjusting rotating wheel 14 is fixed on the top surface of the control valve 10, and the other end of the adjusting rotating wheel 14 is positioned outside the top surface of the cover plate 8;
a second bevel gear is fixed at the position of the rotating shaft connected with the bevel gear, and the second bevel gear is in transmission connection with the bevel gear;
the use flow is as follows: when the cross-linked sodium hyaluronate gel strain culturing device works, the regulating rotating wheel 14 connected with the control valve 10 is rotated, the liquid nitrogen box 9 and the liquid outlet pipe 11 of the cooling box 7 are communicated with the inside of the control valve 10, then liquid nitrogen flows to the inner side of the cooling box 7 through the liquid outlet pipe 11, at the moment, the driving motor 2 is started to drive the ventilation blades 6 to rotate, so that air in the box body 1 and air in the cooling box 7 can be circularly blown, cold air generated by volatilizing the liquid nitrogen in the cooling box 7 is conveyed into the box body 1, the inside of the box body 1 is cooled to a temperature required by the culture of the cross-linked sodium hyaluronate gel strain for injection, and then the strain to be cultured is placed into the inner side of the culture tray 4 for culturing;
it should be noted that: the opening of the adjusting rotary wheel 14 can be larger at the earlier stage of adjusting the control valve 10, when the internal temperature of the tank body 1 is stable, the adjusting rotary wheel 14 can be adjusted to stably provide quantitative liquid nitrogen to enter the cooling tank 7, the internal temperature of the tank body 1 is kept, and the saving and the use of the liquid nitrogen can be facilitated;
it should be noted that: according to the utility model, the circulation ports are formed on the two sides of the cooling box 7 and can be used for circulating air in the box body 1, so that the blowing efficiency of the ventilation blades 6 on the air in the box body 1 is ensured.
In this embodiment, the cooling box 7 is arranged on one side of the box body 1 and is communicated with the interior of the box body 1, and the ventilation blades 6 are arranged in the cooling box 7 to convey air to the interior of the box body 1, so that the liquid nitrogen at the top of the cover plate 8 can convey the low temperature generated in the cooling box 7 to the interior of the box body 1, and therefore, when the device cultures the sodium hyaluronate gel strain, the culture temperature of the strain can be kept at all times, the culture quality of the strain is improved, and the practicability of the device is stronger.
Example two
1-4, based on the embodiment 1, a thermometer 12 is fixed on one side of the top surface of the cover plate 8, and the bottom of the thermometer 12 is communicated with the inner side of the box body 1;
one end of the thermometer 12 connected with the inside of the box body 1 is fixedly provided with a temperature detector 13, and the temperature detector 13 is electrically connected with the thermometer 12;
the liquid nitrogen box 9 outer wall one side has seted up annotates liquid mouth 15, annotate liquid mouth 15 outside screw thread and connect soon and have sealed lid 16.
In the embodiment, the temperature measuring meter 12 can be arranged to observe the temperature inside the box body 1 by adopting the temperature detector 13 at any time, so that the culture temperature inside the box body 1 is ensured to be more accurate;
the liquid injection port 15 and the sealing cover 16 connected with the outer side of the liquid injection port 15 are convenient for adding liquid nitrogen in the liquid nitrogen box 9, and the service life of the liquid nitrogen box 9 is prolonged.
The above-described embodiments are merely a few preferred embodiments of the present utility model, and many alternative modifications and combinations of the above-described embodiments will be apparent to those skilled in the art based on the technical solutions of the present utility model and the related teachings of the above-described embodiments.
Claims (7)
1. The utility model provides a cross-linked sodium hyaluronate gel incubator for injection, includes box (1), is fixed in driving motor (2) of box (1) bottom surface one end, rotates and connects in driving turntable (3) of the inside both sides of box (1), driving turntable (3) bottom is connected with driving motor (2) transmission, driving turntable (3) top is connected with cultivates dish (4), its characterized in that still includes:
the cooling box (7) is arranged on one side of the inside of the box body (1), the middle part of the inner side of the cooling box (7) is rotationally connected with a ventilation blade (6), and the ventilation blade (6) is in transmission connection with the driving motor (2);
the liquid nitrogen box comprises a cover plate (8), wherein the cover plate (8) is covered on the top surface of the box body (1), a liquid nitrogen box (9) is fixed inside the cover plate (8), a control valve (10) is fixed on one side of the liquid nitrogen box (9), a liquid outlet pipe (11) is arranged on the inner side of the control valve (10) in a penetrating mode, and two ends of the liquid outlet pipe (11) are respectively communicated with the inner sides of the liquid nitrogen box (9) and the cooling box (7).
2. The cross-linked sodium hyaluronate gel incubator for injection according to claim 1, wherein a rotating shaft is fixed at the driving end of the driving motor (2), a bevel gear is fixed at the driving connection position of the driving turntable (3) and the driving motor (2) and is in meshed transmission connection with the driving motor (2), a belt pulley (5) is fixed at one end of the rotating shaft far away from the driving motor (2), a driving belt is sleeved outside the belt pulley (5), and the other end of the driving belt is sleeved on the outer wall of one end of the ventilation blade (6).
3. The cross-linked sodium hyaluronate gel incubator for injection according to claim 1, wherein a thermometer (12) is fixed on one side of the top surface of the cover plate (8), and the bottom of the thermometer (12) is communicated with the inner side of the incubator body (1).
4. The cross-linked sodium hyaluronate gel incubator for injection according to claim 3, wherein one end of the thermometer (12) connected with the inside of the incubator body (1) is fixed with a temperature detector (13), and the temperature detector (13) is electrically connected with the thermometer (12).
5. The cross-linked sodium hyaluronate gel incubator for injection according to claim 1, wherein the control valve (10) has a top surface fixed with an adjusting wheel (14), and the other end of the adjusting wheel (14) is located outside the top surface of the cover plate (8).
6. The cross-linked sodium hyaluronate gel incubator for injection according to claim 1, wherein a liquid injection port (15) is formed on one side of the outer wall of the liquid nitrogen box (9), and a sealing cover (16) is screwed on the outer side of the liquid injection port (15).
7. The cross-linked sodium hyaluronate gel incubator for injection according to claim 2, wherein the position of the rotating shaft connected with the bevel gear is fixed with a second bevel gear, and the second bevel gear is in transmission connection with the bevel gear.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321863176.0U CN220376646U (en) | 2023-07-17 | 2023-07-17 | Cross-linked sodium hyaluronate gel incubator for injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321863176.0U CN220376646U (en) | 2023-07-17 | 2023-07-17 | Cross-linked sodium hyaluronate gel incubator for injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220376646U true CN220376646U (en) | 2024-01-23 |
Family
ID=89561190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321863176.0U Active CN220376646U (en) | 2023-07-17 | 2023-07-17 | Cross-linked sodium hyaluronate gel incubator for injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220376646U (en) |
-
2023
- 2023-07-17 CN CN202321863176.0U patent/CN220376646U/en active Active
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