CN219935865U - Sample liquid flow adjustable immunochromatography detection card - Google Patents
Sample liquid flow adjustable immunochromatography detection card Download PDFInfo
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- CN219935865U CN219935865U CN202321277782.4U CN202321277782U CN219935865U CN 219935865 U CN219935865 U CN 219935865U CN 202321277782 U CN202321277782 U CN 202321277782U CN 219935865 U CN219935865 U CN 219935865U
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- 238000001514 detection method Methods 0.000 title claims abstract description 112
- 239000007788 liquid Substances 0.000 title claims abstract description 30
- 238000003317 immunochromatography Methods 0.000 title abstract description 82
- 239000012295 chemical reaction liquid Substances 0.000 claims abstract description 90
- 238000012360 testing method Methods 0.000 claims abstract description 86
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 76
- 239000012528 membrane Substances 0.000 claims abstract description 19
- 230000008105 immune reaction Effects 0.000 claims abstract description 15
- 238000003556 assay Methods 0.000 claims description 14
- 238000003908 quality control method Methods 0.000 claims description 9
- 239000000758 substrate Substances 0.000 claims description 9
- 238000007789 sealing Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims 7
- 238000000034 method Methods 0.000 abstract description 9
- 238000004090 dissolution Methods 0.000 abstract description 2
- 239000002390 adhesive tape Substances 0.000 description 10
- 238000013461 design Methods 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 5
- 239000002250 absorbent Substances 0.000 description 3
- 230000002745 absorbent Effects 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
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Abstract
The utility model discloses a sample liquid flow adjustable immunochromatography detection card, which solves the technical problem that the detection procedure is complicated by adding a pretreatment step in the immunochromatography detection in the prior art. The utility model comprises an immunochromatography detection card main body, a reagent encapsulated in the immunochromatography detection card main body and a test strip for participating in immune reaction; the reagent is communicated with the test strip, and a shutoff film is arranged on a channel of the reagent and the test strip. According to the utility model, the intercepting membrane is arranged at the inlet of the reaction liquid, the liquid sample is intercepted by the intercepting membrane on the channels of the reagent and the test strip, after a certain time, the intercepting membrane is dissolved by the reaction liquid, and the liquid sample flows to the sample pad through the exposed inlet of the dissolution so as to continue the immunochromatography reaction. The reaction liquid can be trapped at the reaction liquid inlet of the detection card for 2-20min, so that the pretreatment process of the sample is fully carried out, and the advantage of rapidness and convenience in traditional immunochromatography detection is maintained.
Description
Technical Field
The utility model belongs to the technical field of immunochromatography detection, and particularly relates to a sample liquid flow adjustable immunochromatography detection card.
Background
The immunochromatography technology (ImmunochromatographicAssay, ICA) is an analysis method combining the immunochromatography technology and the immunochromatography technology developed at the end of the 20 th century, has the characteristics of specificity, simplicity and rapidness in operation and the like, and is widely applied to important fields such as clinical diagnosis, environmental monitoring, food safety and the like. The immunochromatography technology takes colloidal gold or fluorescent microspheres as markers, and the target is qualitatively detected or semi-quantitatively analyzed through strip color development or fluorescence intensity. The main part of the test card participating in immune reaction is a test strip or a test strip and sample diluent, and the test sample has insufficient combination with fluorescent substances due to shorter stay time of the test sample on the sample pad, so that the error of the test result is large.
In some immunochromatographic detection projects, a detection object usually exists in a form of forming a complex with a corresponding binding protein, and in order to accurately monitor the content of the substance in a sample, the sample needs to be subjected to pretreatment to convert the detection object from the complex form to a free form. However, since the pretreatment of the sample takes a certain time, the existing immunochromatographic assay card has no corresponding area to complete the reaction. The traditional method for solving the technical problems has two methods, one is that a customer automatically completes a pretreatment step before adopting an immunochromatography detection card for detection, so that the operation complexity and the time required by the whole detection reaction are greatly increased; secondly, a pretreatment step is added on the full-automatic immunity detector, so that the detection procedure is more complex and longer time is required to finish the immunity chromatography detection.
Therefore, it is necessary to design an immunochromatographic assay card with adjustable sample liquid flow.
Disclosure of Invention
The utility model aims to solve the technical problems that: provides an immunochromatography detection card with adjustable sample liquid flow, so as to at least solve the technical problems.
In order to achieve the above purpose, the technical scheme adopted by the utility model is as follows:
a sample liquid flow adjustable immunochromatography detection card comprises an immunochromatography detection card main body, a reagent encapsulated in the immunochromatography detection card main body and a test strip for participating in immune reaction; the reagent is communicated with the test strip, and a shutoff film is arranged on a channel of the reagent and the test strip.
Further, a reaction liquid inlet is arranged on the immunochromatography detection card main body, the reagent and the test strip are communicated through the reaction liquid inlet, and the intercepting membrane is positioned at the reaction liquid inlet.
Further, the immunochromatography detection card body comprises an upper card shell, a small card shell and a lower card shell which are respectively encapsulated on the top surface and the bottom surface of the upper card shell, and a reaction liquid inlet is formed in the upper card shell.
Further, a layer of double faced adhesive tape A is attached to the bottom surface of the upper clamping shell around the reaction liquid inlet, and the intercepting membrane is sealed at the reaction liquid inlet through the double faced adhesive tape A.
Further, the test strip is encapsulated between the upper and lower cartridge shells, and the reagent is encapsulated between the small and upper cartridge shells.
Further, a sample adding port and a reaction bin which are communicated with the reagent are arranged on the small card shell.
Further, the immunochromatographic assay card body further comprises a double-sided tape B for sealing the small card case and the upper card case.
Further, a detection window for observing the test strip is arranged on the upper card shell.
Further, the test strip comprises a substrate, and a sample pad, a reaction pad, a detection line, a quality control line and water absorbing paper which are sequentially distributed along the length direction of the substrate, wherein a reaction liquid inlet is opposite to the outer end of the sample pad, and a detection window is positioned right above the reaction pad, the detection line and the quality control line.
Further, the reagent is a lyophilized reagent pellet.
Compared with the prior art, the utility model has the following beneficial effects:
the utility model has simple structure, scientific and reasonable design and convenient use, the intercepting membrane is arranged at the inlet of the reaction liquid, the liquid sample is intercepted by the intercepting membrane on the channels of the reagent and the test paper strip, and after a certain time, the intercepting membrane is dissolved by the reaction liquid and flows to the sample pad through the exposed inlet to continue the immunochromatography reaction. The reaction liquid can be trapped at the reaction liquid inlet of the detection card for 2-20min, so that the pretreatment process of the sample is fully carried out, and the advantage of rapidness and convenience in traditional immunochromatography detection is maintained.
Drawings
FIG. 1 is a schematic diagram of the structure of the present utility model.
Fig. 2 is a schematic diagram of the external shape of the present utility model.
Wherein, the names corresponding to the reference numerals are:
1 to a small clamping shell; 1-1 to a sample adding port; 1-2 to a reaction bin; 2-reagent; 3-double faced adhesive tape B; 4-upper clamping shell; 4-1 to a reaction liquid inlet; 4-2 to a detection window; 5-test paper strips; 5-1 to a substrate; 5-2 to sample pad; 5-3 to a reaction pad; 5-4 to a detection line; 5-5 to a quality control line; 5-6 to absorbent paper; 6-lower clamping shell; 7-1 to double faced adhesive tape A;7-2 to a shutoff membrane; 8-immunity chromatography detection card main body.
Detailed Description
The present utility model will be described in further detail with reference to the accompanying drawings, in order to make the objects, technical solutions and advantages of the present utility model more apparent. It will be apparent that the described embodiments are only some, but not all, embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Example 1.
As shown in fig. 1-2, the sample liquid flow-adjustable immunochromatography detection card provided by the utility model comprises an immunochromatography detection card main body 8, a reagent 2 encapsulated in the immunochromatography detection card main body 8 and a test strip 5 for participating in immune reaction; the reagent 2 is communicated with the test strip 5, and a shutoff film 7-2 is arranged on the channel of the reagent 2 and the test strip 5.
The utility model has simple structure, scientific and reasonable design and convenient use, the liquid sample is intercepted by the intercepting membrane on the channel of the reagent and the test strip by arranging the intercepting membrane at the inlet of the reaction liquid, and after a certain time, the intercepting membrane is dissolved by the reaction liquid and flows to the sample pad through the inlet exposed by dissolution so as to continue the immunochromatography reaction. The reaction liquid can be trapped at the reaction liquid inlet of the detection card for 2-20min, so that the pretreatment process of the sample is fully carried out, and the advantage of rapidness and convenience in traditional immunochromatography detection is maintained. The intercepting film of the embodiment is a water-soluble polyvinyl alcohol film.
Example 2.
As shown in fig. 1-2, the sample liquid flow-adjustable immunochromatography detection card provided by the utility model comprises an immunochromatography detection card main body 8, a reagent 2 encapsulated in the immunochromatography detection card main body 8 and a test strip 5 for participating in immune reaction; the reagent 2 is communicated with the test strip 5, and a shutoff film 7-2 is arranged on the channel of the reagent 2 and the test strip 5. The immunochromatography detection card main body 8 is provided with a reaction liquid inlet 4-1, the reagent 2 and the test strip 5 are communicated through the reaction liquid inlet 4-1, and the interception film 7-2 is positioned at the reaction liquid inlet 4-1.
This embodiment 2 gives a more preferable structure of the immunochromatographic test card body 8 on the basis of embodiment 1, specifically: the immunochromatography detection card main body 8 is provided with a reaction liquid inlet 4-1, the reagent 2 and the test strip 5 are communicated through the reaction liquid inlet 4-1, and the interception film 7-2 is positioned at the reaction liquid inlet 4-1. By the design, the reaction liquid can smoothly flow to the test strip 5, and the interception film 7-2 ensures that the reaction liquid can be intercepted on a flow channel through which the reaction liquid flows.
Example 3.
As shown in fig. 1-2, the sample liquid flow-adjustable immunochromatography detection card provided by the utility model comprises an immunochromatography detection card main body 8, a reagent 2 encapsulated in the immunochromatography detection card main body 8 and a test strip 5 for participating in immune reaction; the reagent 2 is communicated with the test strip 5, and a shutoff film 7-2 is arranged on the channel of the reagent 2 and the test strip 5. The immunochromatography detection card main body 8 is provided with a reaction liquid inlet 4-1, the reagent 2 and the test strip 5 are communicated through the reaction liquid inlet 4-1, and the interception film 7-2 is positioned at the reaction liquid inlet 4-1. The immunochromatography detection card main body 8 comprises an upper card shell 4, a small card shell 1 and a lower card shell 6 which are respectively encapsulated on the top surface and the bottom surface of the upper card shell 4, and a reaction liquid inlet 4-1 is formed in the upper card shell 4.
This embodiment 3 gives a more preferable structure of the immunochromatographic test card body 8 on the basis of embodiment 2, specifically: the immunochromatography detection card main body 8 comprises an upper card shell 4, a small card shell 1 and a lower card shell 6 which are respectively encapsulated on the top surface and the bottom surface of the upper card shell 4, and a reaction liquid inlet 4-1 is formed in the upper card shell 4. The design makes the whole structure more compact and applicable.
Example 4.
As shown in fig. 1-2, the sample liquid flow-adjustable immunochromatography detection card provided by the utility model comprises an immunochromatography detection card main body 8, a reagent 2 encapsulated in the immunochromatography detection card main body 8 and a test strip 5 for participating in immune reaction; the reagent 2 is communicated with the test strip 5, and a shutoff film 7-2 is arranged on the channel of the reagent 2 and the test strip 5. The immunochromatography detection card main body 8 is provided with a reaction liquid inlet 4-1, the reagent 2 and the test strip 5 are communicated through the reaction liquid inlet 4-1, and the interception film 7-2 is positioned at the reaction liquid inlet 4-1. The immunochromatography detection card main body 8 comprises an upper card shell 4, a small card shell 1 and a lower card shell 6 which are respectively encapsulated on the top surface and the bottom surface of the upper card shell 4, and a reaction liquid inlet 4-1 is formed in the upper card shell 4. A layer of double faced adhesive tape A7-1 is attached to the bottom surface of the upper clamping shell 4 around the reaction liquid inlet 4-1, and the intercepting membrane 7-2 is sealed at the position of the reaction liquid inlet 4-1 through the double faced adhesive tape A7-1.
This example 4 gives a more preferable connection structure between the shut-off film 7-2 and the upper card case 4 on the basis of example 3, specifically: a layer of double faced adhesive tape A7-1 is attached to the bottom surface of the upper clamping shell 4 around the reaction liquid inlet 4-1, and the intercepting membrane 7-2 is sealed at the position of the reaction liquid inlet 4-1 through the double faced adhesive tape A7-1. The double-sided adhesive tape A7-1 surrounds the reaction liquid inlet 4-1 and is attached with the intercepting film 7-2, the intercepting film 7-2 can seal the whole reaction liquid inlet 4-1, so that when the reaction liquid flows through the reaction liquid inlet 4-1, all the intercepting film 7-2 is used for being caught and intercepted, until the intercepting film 7-2 is dissolved by the reaction liquid after the preset time, the reaction liquid can flow to a sample pad through an inlet exposed by the intercepting film 7-2 after the dissolving so as to continue the immunochromatography reaction, the reaction liquid can be intercepted at the position of the reaction liquid inlet of the detection card for 2-20min, and the advantages of rapidness and simplicity in traditional immunochromatography detection are reserved while the sample pretreatment process is fully ensured.
Example 5.
As shown in fig. 1-2, the sample liquid flow-adjustable immunochromatography detection card provided by the utility model comprises an immunochromatography detection card main body 8, a reagent 2 encapsulated in the immunochromatography detection card main body 8 and a test strip 5 for participating in immune reaction; the reagent 2 is communicated with the test strip 5, and a shutoff film 7-2 is arranged on the channel of the reagent 2 and the test strip 5. The immunochromatography detection card main body 8 is provided with a reaction liquid inlet 4-1, the reagent 2 and the test strip 5 are communicated through the reaction liquid inlet 4-1, and the interception film 7-2 is positioned at the reaction liquid inlet 4-1. The immunochromatography detection card main body 8 comprises an upper card shell 4, a small card shell 1 and a lower card shell 6 which are respectively encapsulated on the top surface and the bottom surface of the upper card shell 4, and a reaction liquid inlet 4-1 is formed in the upper card shell 4. The test strip 5 is encapsulated between the upper cartridge 4 and the lower cartridge 6, and the reagent 2 is encapsulated between the small cartridge 1 and the upper cartridge 4.
This example 5 gives a more preferable connection structure between the test strip 5, the reagent 2 and the immunochromatographic test card body 8 on the basis of example 3, specifically: the test strip 5 is encapsulated between the upper cartridge 4 and the lower cartridge 6, and the reagent 2 is encapsulated between the small cartridge 1 and the upper cartridge 4. The design makes the whole structure more compact and applicable.
Example 6.
As shown in fig. 1-2, the sample liquid flow-adjustable immunochromatography detection card provided by the utility model comprises an immunochromatography detection card main body 8, a reagent 2 encapsulated in the immunochromatography detection card main body 8 and a test strip 5 for participating in immune reaction; the reagent 2 is communicated with the test strip 5, and a shutoff film 7-2 is arranged on the channel of the reagent 2 and the test strip 5. The immunochromatography detection card main body 8 is provided with a reaction liquid inlet 4-1, the reagent 2 and the test strip 5 are communicated through the reaction liquid inlet 4-1, and the interception film 7-2 is positioned at the reaction liquid inlet 4-1. The immunochromatography detection card main body 8 comprises an upper card shell 4, a small card shell 1 and a lower card shell 6 which are respectively encapsulated on the top surface and the bottom surface of the upper card shell 4, and a reaction liquid inlet 4-1 is formed in the upper card shell 4. The test strip 5 is encapsulated between the upper cartridge 4 and the lower cartridge 6, and the reagent 2 is encapsulated between the small cartridge 1 and the upper cartridge 4. The small card shell 1 is provided with a sample adding port 1-1 and a reaction bin 1-2 which are communicated with a reagent 2.
This example 6 gives a more preferred construction of the small card housing 1 on the basis of example 5, in particular: the small card shell 1 is provided with a sample adding port 1-1 and a reaction bin 1-2 which are communicated with a reagent 2. The sample adding port 1-1 facilitates the addition of a sample into the immunochromatographic detection card body 8.
Example 7.
As shown in fig. 1-2, the sample liquid flow-adjustable immunochromatography detection card provided by the utility model comprises an immunochromatography detection card main body 8, a reagent 2 encapsulated in the immunochromatography detection card main body 8 and a test strip 5 for participating in immune reaction; the reagent 2 is communicated with the test strip 5, and a shutoff film 7-2 is arranged on the channel of the reagent 2 and the test strip 5. The immunochromatography detection card main body 8 is provided with a reaction liquid inlet 4-1, the reagent 2 and the test strip 5 are communicated through the reaction liquid inlet 4-1, and the interception film 7-2 is positioned at the reaction liquid inlet 4-1. The immunochromatography detection card main body 8 comprises an upper card shell 4, a small card shell 1 and a lower card shell 6 which are respectively encapsulated on the top surface and the bottom surface of the upper card shell 4, and a reaction liquid inlet 4-1 is formed in the upper card shell 4. The immunochromatographic assay card body 8 further comprises a double-sided tape B3 for sealing the small card case 1 and the upper card case 4.
This embodiment 7 gives a more preferable structure of the immunochromatographic test card body 8 on the basis of embodiment 3, specifically: the immunochromatographic assay card body 8 further comprises a double-sided tape B3 for sealing the small card case 1 and the upper card case 4. By the design, the sealing performance of the small clamping shell 1 and the upper clamping shell 4 can be effectively guaranteed, and meanwhile, the double-sided adhesive material is simple and easy to obtain and is suitable for large-scale production.
Example 8.
As shown in fig. 1-2, the sample liquid flow-adjustable immunochromatography detection card provided by the utility model comprises an immunochromatography detection card main body 8, a reagent 2 encapsulated in the immunochromatography detection card main body 8 and a test strip 5 for participating in immune reaction; the reagent 2 is communicated with the test strip 5, and a shutoff film 7-2 is arranged on the channel of the reagent 2 and the test strip 5. The immunochromatography detection card main body 8 is provided with a reaction liquid inlet 4-1, the reagent 2 and the test strip 5 are communicated through the reaction liquid inlet 4-1, and the interception film 7-2 is positioned at the reaction liquid inlet 4-1. The immunochromatography detection card main body 8 comprises an upper card shell 4, a small card shell 1 and a lower card shell 6 which are respectively encapsulated on the top surface and the bottom surface of the upper card shell 4, and a reaction liquid inlet 4-1 is formed in the upper card shell 4. The upper cartridge case 4 is provided with a detection window 4-2 for observing the test strip 5.
This embodiment 8 gives a more preferable structure of the upper shell 4 based on embodiment 3, specifically: the upper cartridge case 4 is provided with a detection window 4-2 for observing the test strip 5. By the design, the change generated by the test strip 5 can be observed conveniently during detection.
Example 9.
As shown in fig. 1-2, the sample liquid flow-adjustable immunochromatography detection card provided by the utility model comprises an immunochromatography detection card main body 8, a reagent 2 encapsulated in the immunochromatography detection card main body 8 and a test strip 5 for participating in immune reaction; the reagent 2 is communicated with the test strip 5, and a shutoff film 7-2 is arranged on the channel of the reagent 2 and the test strip 5. The immunochromatography detection card main body 8 is provided with a reaction liquid inlet 4-1, the reagent 2 and the test strip 5 are communicated through the reaction liquid inlet 4-1, and the interception film 7-2 is positioned at the reaction liquid inlet 4-1. The immunochromatography detection card main body 8 comprises an upper card shell 4, a small card shell 1 and a lower card shell 6 which are respectively encapsulated on the top surface and the bottom surface of the upper card shell 4, and a reaction liquid inlet 4-1 is formed in the upper card shell 4. The upper cartridge case 4 is provided with a detection window 4-2 for observing the test strip 5. The test strip 5 comprises a substrate 5-1, and a sample pad 5-2, a reaction pad 5-3, a detection line 5-4, a quality control line 5-5 and absorbent paper 5-6 which are sequentially distributed along the length direction of the substrate 5-1, wherein a reaction liquid inlet 4-1 is opposite to the outer end of the sample pad 5-2, and a detection window 4-2 is positioned right above the reaction pad 5-3, the detection line 5-4 and the quality control line 5-5.
In this embodiment 9, on the basis of embodiment 8, a more preferable structure of the test strip 5 is given, specifically: the test strip 5 comprises a substrate 5-1, and a sample pad 5-2, a reaction pad 5-3, a detection line 5-4, a quality control line 5-5 and absorbent paper 5-6 which are sequentially distributed along the length direction of the substrate 5-1, wherein a reaction liquid inlet 4-1 is opposite to the outer end of the sample pad 5-2, and a detection window 4-2 is positioned right above the reaction pad 5-3, the detection line 5-4 and the quality control line 5-5. The design makes the whole structure more compact and applicable. The reaction liquid inlet 4-1 is arranged at the forefront end of the sample pad 5-2, so that the residue of the reaction liquid is reduced, the background signal is reduced, and the strength and the repeatability of the detection signal are improved.
Example 10.
As shown in fig. 1-2, the sample liquid flow-adjustable immunochromatography detection card provided by the utility model comprises an immunochromatography detection card main body 8, a reagent 2 encapsulated in the immunochromatography detection card main body 8 and a test strip 5 for participating in immune reaction; the reagent 2 is communicated with the test strip 5, and a shutoff film 7-2 is arranged on the channel of the reagent 2 and the test strip 5. Reagent 2 is a freeze-dried reagent ball.
This example 10 gives a more preferred structure for reagent 2 on the basis of example 1, specifically: reagent 2 is a freeze-dried reagent ball. The freeze-dried reagent ball has small volume, is favorable for the whole miniaturization of the immunochromatography detection card, has stable whole structure and can be stored for a long time.
The utility model provides an immunochromatography detection card with a retaining film, which comprises an immunochromatography detection card main body, wherein the retaining film and a test strip for participating in immune reaction are attached to a reaction liquid inlet. The double faced adhesive tape is used for fixing the interception film below the reaction liquid inlet, the liquid can be intercepted above the reaction liquid inlet by the interception film, the interception film can be gradually dissolved by the reaction liquid in a few minutes, and the reaction liquid further flows to the sample pad through the exposed inlet, so that the subsequent immunochromatography detection step is completed.
The utility model relates to a specific packaging structure for packaging a freeze-dried reagent ball between a small card shell 1 and an upper card shell 4, which belongs to the prior art, and the specific connection and fixation among the small card shell 1, the upper card shell 4 and a lower card shell 6 belong to the prior art, and can refer to patent number CN201911279850.9, and patent technology of a microfluidic immunochromatography detection card packaged with the freeze-dried reagent ball is named.
When a user uses the immunochromatography reaction liquid, a liquid sample is injected from the sample injection port 1-1, the liquid sample is intercepted by the intercepting membrane 7-2 at the reaction liquid inlet 4-1, after a certain time, the intercepting membrane is dissolved by the liquid sample to expose the inlet and the outlet, and the liquid sample flows to the sample pad 5-2 through the exposed inlet after the intercepting membrane is dissolved to continue the immunochromatography reaction. The interception membrane can intercept the reaction liquid at the reaction liquid inlet of the detection card for 2-20min, so that the advantage of rapidness and convenience in traditional immunochromatography detection is maintained while the pretreatment process of the sample is fully carried out. The reaction liquid inlet 4-1 is arranged at the forefront end of the sample pad, so that the residue of the reaction liquid is reduced, the background signal is reduced, and the strength and the repeatability of the detection signal are improved.
Finally, it should be noted that: the above embodiments are merely preferred embodiments of the present utility model to illustrate the technical solution of the present utility model, but not to limit the scope of the present utility model. That is, even though the main design concept and spirit of the present utility model is modified or finished in an insubstantial manner, the technical problem solved by the present utility model is still consistent with the present utility model, and all the technical problems are included in the protection scope of the present utility model; in addition, the technical scheme of the utility model is directly or indirectly applied to other related technical fields, and the technical scheme is included in the scope of the utility model.
Claims (10)
1. The immunochromatographic detection card is characterized by comprising an immunochromatographic detection card main body (8), a reagent (2) and a test strip (5) which are encapsulated in the immunochromatographic detection card main body (8) and are used for participating in immune reaction; the reagent (2) is communicated with the test strip (5), and a shutoff film (7-2) is arranged on the channel of the reagent (2) and the test strip (5).
2. The immunochromatographic assay card with adjustable sample liquid flows according to claim 1, wherein a reaction liquid inlet (4-1) is arranged on the immunochromatographic assay card main body (8), the reagent (2) and the test strip (5) are communicated through the reaction liquid inlet (4-1), and the intercepting membrane (7-2) is positioned at the reaction liquid inlet (4-1).
3. The immunochromatographic assay card with adjustable sample liquid flows according to claim 2, wherein the immunochromatographic assay card body (8) comprises an upper card shell (4), and a small card shell (1) and a lower card shell (6) which are respectively encapsulated on the top surface and the bottom surface of the upper card shell (4), and the reaction liquid inlet (4-1) is formed in the upper card shell (4).
4. A sample fluid flow-adjustable immunochromatographic assay card according to claim 3, in which a layer of double-sided tape a (7-1) is attached to the bottom surface of the upper card housing (4) around the reaction fluid inlet (4-1), and the shut-off film (7-2) is sealed at the reaction fluid inlet (4-1) by the double-sided tape a (7-1).
5. A sample fluid flow-adjustable immunochromatographic assay card according to claim 3, in which the test strip (5) is enclosed between the upper cassette (4) and the lower cassette (6) and the reagent (2) is enclosed between the small cassette (1) and the upper cassette (4).
6. The immunochromatographic assay card with adjustable sample liquid flows according to claim 5, wherein a sample adding port (1-1) and a reaction bin (1-2) which are communicated with the reagent (2) are formed on the small card shell (1).
7. A sample fluid flow-adjustable immunochromatographic test card according to claim 3, in which the immunochromatographic test card body (8) further comprises a double-sided tape B (3) for sealing the small card case (1) and the upper card case (4).
8. A sample fluid flow-adjustable immunochromatographic test card according to claim 3, in which the upper cassette shell (4) is provided with a detection window (4-2) for observing the test strip (5).
9. The sample liquid flow-adjustable immunochromatographic assay card according to claim 8, wherein the test strip (5) comprises a substrate (5-1), and sample pads (5-2), a reaction pad (5-3), a detection line (5-4), a quality control line (5-5) and water absorbing paper (5-6) which are sequentially distributed along the length direction of the substrate (5-1), the reaction liquid inlet (4-1) is opposite to the outer end of the sample pad (5-2), and the detection window (4-2) is positioned right above the reaction pad (5-3), the detection line (5-4) and the quality control line (5-5).
10. The sample fluid flow-adjustable immunochromatographic assay card of claim 1, wherein the reagent (2) is a lyophilized reagent sphere.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321277782.4U CN219935865U (en) | 2023-05-24 | 2023-05-24 | Sample liquid flow adjustable immunochromatography detection card |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321277782.4U CN219935865U (en) | 2023-05-24 | 2023-05-24 | Sample liquid flow adjustable immunochromatography detection card |
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| Publication Number | Publication Date |
|---|---|
| CN219935865U true CN219935865U (en) | 2023-10-31 |
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|---|---|---|---|
| CN202321277782.4U Active CN219935865U (en) | 2023-05-24 | 2023-05-24 | Sample liquid flow adjustable immunochromatography detection card |
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| Country | Link |
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| CN (1) | CN219935865U (en) |
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2023
- 2023-05-24 CN CN202321277782.4U patent/CN219935865U/en active Active
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