CN219915383U

CN219915383U - Fluorescence module for fluorescence microscopy equipment and fluorescence microscopy equipment

Info

Publication number: CN219915383U
Application number: CN202321118753.3U
Authority: CN
Inventors: 朱宁; 陈锦清
Original assignee: Hunan Pinxin Bioengineering Co ltd
Current assignee: Hunan Pinxin Bioengineering Co ltd
Priority date: 2023-05-11
Filing date: 2023-05-11
Publication date: 2023-10-27
Anticipated expiration: 2033-05-11

Abstract

The utility model provides a fluorescence module for fluorescence microscopy equipment and the fluorescence microscopy equipment, wherein the fluorescence module comprises a bottom plate, a fluorescence unit mounting plate is movably arranged on one side of the bottom plate, a plurality of fluorescence units are arranged side by side on one end, far away from the bottom plate, of the fluorescence unit mounting plate, and the fluorescence units and the fluorescence unit mounting plate are in a detachable connection mode; according to the fluorescent module for the fluorescent microscopic equipment and the fluorescent microscopic equipment provided by the utility model, each fluorescent module and the LED light source inside the fluorescent module can adopt different sizes and optical parameters according to different biological slices, so that the fluorescent module and the LED light source for the fluorescent microscopic equipment are rapidly switched among a plurality of fluorescent modules by driving the fluorescent unit mounting plate along the sliding rail through the motor, and the requirements of observation of various biological slices are met.

Description

Fluorescence module for fluorescence microscopy equipment and fluorescence microscopy equipment

Technical Field

The utility model relates to the technical field of medical equipment, in particular to a fluorescence module for fluorescence microscopy equipment, and further provides the fluorescence microscopy equipment.

Background

With the development of laser technology, more and more modern microscopy techniques are rapidly developed. The fluorescence microscopic imaging technology is increasingly widely applied in the biomedical research field, and the technical development is also rapidly advanced, so that the fluorescence microscopic imaging technology becomes a popular research field. Fluorescence microscopy can be used to obtain high resolution imaging by exciting fluorescence or nonlinear optical phenomena of the object under test with a laser source.

The single-channel fluorescent module part can only carry out pathological analysis aiming at a certain biological slice, and has single functionality. The multichannel fluorescent modules exist in the market at present, but the positioning accuracy is lower when the fluorescent modules are switched, so that the edge of a biological slice sampling area is affected to have an unoccupied part; and the switching time between different fluorescent modules is long, which affects the observation efficiency.

Disclosure of Invention

Aiming at the problems in the prior art, the utility model provides a fluorescence module for fluorescence microscopy equipment, which solves the problems in the background art.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

a fluorescence module for fluorescence microscopy equipment, includes the bottom plate, mobilizable fluorescent unit mounting panel that is provided with on one side of bottom plate, keep away from on the fluorescent unit mounting panel one end of bottom plate is last to be provided with several fluorescent unit side by side, fluorescent unit with be detachable connected mode between the fluorescent unit mounting panel.

In one embodiment, a sliding rail is arranged on the bottom plate, a sliding block is arranged on the sliding rail, one end, far away from the fluorescent unit, of the fluorescent unit mounting plate is connected with the sliding block, a connecting plate is arranged on the fluorescent unit mounting plate, a motor is arranged on the bottom plate, and a main shaft of the motor penetrates through the connecting plate and is in threaded connection with the connecting plate.

In one embodiment, the base plate is provided with a motor support and a bearing seat, the motor is arranged on the motor support, and a main shaft of the motor sequentially penetrates through the motor support and the connecting plate and is inserted into the bearing seat.

In one embodiment, a photoelectric sensor is arranged on the motor support, an induction notch is formed in the upper end of the photoelectric sensor, an induction plate is arranged on the connecting plate, and a limit screw is arranged on one side, close to the connecting plate, of the bearing seat.

In one embodiment, the longitudinal section of the fluorescent unit mounting plate is in an L shape, a plurality of clamping grooves are formed in the lower end face of the fluorescent unit mounting plate side by side, and a plurality of fluorescent units are correspondingly installed in the clamping grooves through screws.

In one embodiment, the fluorescent unit comprises a fluorescent filter sleeve, a convex lens sleeve, a lamp source sleeve and a shell, wherein a first transverse through hole is formed in the right end of the shell, a second longitudinal through hole is formed in the left end of the shell, the first through hole and the second through hole are communicated with each other, the lamp source sleeve is movably arranged in the right end of the first through hole, the convex lens sleeve is arranged in the left end of the first through hole, and the fluorescent filter sleeve is arranged in the second through hole.

In one embodiment, an inner thread is disposed on the inner wall of the right end of the first through hole, an outer thread is disposed on the outer side wall of the light source sleeve, and the light source sleeve is screwed into the first through hole.

In one embodiment, the convex lens kit includes a plurality of convex lenses spaced apart inside the first through hole.

In one embodiment, the fluorescent filter set comprises a first filter, a second filter and a reflecting mirror, wherein the first filter is arranged inside the first through hole and is positioned on the left side of the convex lens set, the second filter is positioned inside the upper end of the second through hole, and the reflecting mirror is inclined by 45 degrees and is arranged inside the second through hole and is positioned on the left side of the first filter.

The utility model also provides fluorescence microscopy equipment, which is characterized by comprising the fluorescence module for fluorescence microscopy equipment, a camera, a lens and a slide seat, wherein the slide seat is provided with a slide, the camera, the fluorescence module, the lens and the slide are sequentially arranged from top to bottom, and the central lines of the reflector and the lens are positioned on the same straight line along the longitudinal direction.

Compared with the prior art, each fluorescent module and the LED light source inside the fluorescent module for the fluorescent microscopic equipment adopt different sizes and optical parameters according to different biological slices, so that the fluorescent module for the fluorescent microscopic equipment drives the fluorescent unit mounting plate to move along the slide rail through the motor, and further, the rapid switching among the fluorescent modules is realized, different biological slices can be imaged, and the observation requirement of multiple biological slices is met; the fluorescent module for fluorescent microscopy equipment provided by the utility model has the advantages of side-by-side layout, compact structure, rapid and convenient switching, consistent independent unit reference, and convenience in installation and precision guarantee.

Drawings

FIG. 1 is a schematic view of a partial perspective structure of a fluorescence microscopy apparatus according to the present utility model;

FIG. 2 is a schematic perspective view of a fluorescent unit mounting plate according to the present utility model;

FIG. 3 is a schematic perspective view of a fluorescent unit according to the present utility model;

fig. 4 is a schematic view showing an internal structure of a fluorescent unit in the present utility model.

Detailed Description

In the description of the present utility model, it should be understood that the terms "center," "longitudinal," "transverse," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "axial," "radial," and the like indicate an orientation or positional relationship based on that shown in the drawings, merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present utility model, the meaning of "plurality" is two or more unless specifically defined otherwise.

In the present utility model, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.

In the present utility model, unless expressly stated or limited otherwise, a first feature "up" or "down" a second feature may be the first and second features in direct contact, or the first and second features in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.

In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present utility model. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.

As shown in figures 1-4 of the drawings,

a fluorescence module for fluorescence microscopy equipment, including bottom plate 1, mobilizable fluorescent unit mounting panel 2 that is provided with on one side of bottom plate 1 is provided with a plurality of fluorescent units 3 side by side on the one end that keeps away from bottom plate 1 on the fluorescent unit mounting panel 2, is detachable connected mode between fluorescent unit 3 and the fluorescent unit mounting panel 2.

Specifically, be provided with slide rail 4 on the bottom plate 1, be provided with the slider on the slide rail 4, the one end that keeps away from fluorescence unit 3 on the fluorescence unit mounting panel 2 is connected with the slider, is provided with connecting plate 6 on the fluorescence unit mounting panel 2, is provided with motor 7 on the bottom plate 1, and motor 7's main shaft runs through connecting plate 6, and with the spiro union between connecting plate 6.

Further, a motor support 8 and a bearing seat 9 are arranged on the bottom plate 1, a motor 7 is arranged on the motor support 8, and a main shaft of the motor 7 sequentially penetrates through the motor support 8 and the connecting plate 6 and is inserted into the bearing seat 9.

The structure can be seen from the above: the fluorescent unit mounting plate 2 is driven to move along the sliding rail 4 by the control motor 7, so that the purpose of rapid switching among the fluorescent modules 3 is achieved.

In the embodiment, a photoelectric sensor 10 is arranged on a motor support 8, an induction notch is arranged at the upper end of the photoelectric sensor 10, an induction plate 11 is arranged on a connecting plate 6, and a limit screw 12 is arranged on one side, close to the connecting plate 6, of a bearing seat 9;

when the connecting plate 6 moves to one side of the photoelectric sensor 10 to a certain distance, one end of the sensing plate 11 is inserted into a groove on the photoelectric sensor 10, the photoelectric sensor 10 transmits sensing signals to a control system of a background, the control system controls the motor 7 to stop running, collision between the connecting plate 6 and the motor support 8 is avoided, correspondingly, when the connecting plate 6 moves to one side of the bearing seat 9 to a certain distance, the connecting plate 6 touches the limit screw 12, and the phenomenon of collision between the connecting plate 6 and the bearing seat 9 is avoided under the action of the limit screw 12.

In this embodiment, the longitudinal section of the fluorescent unit mounting plate 2 is in an "L" shape, a plurality of clamping grooves 13 are arranged side by side on the lower end face of the fluorescent unit mounting plate 2, a plurality of fluorescent units 3 are correspondingly installed in the clamping grooves 13 through screws, and each fluorescent unit 3 is conveniently positioned by arranging the clamping grooves 13 so as to be convenient for installation, and meanwhile, the fluorescent units 3 are conveniently assembled and disassembled by matching with the screws.

In this embodiment, the fluorescent unit 3 includes a fluorescent filter set 14, a convex lens set 15, a lamp source set 16 and a housing 17, wherein a first through hole is provided in the right end of the housing 17, a second through hole is provided in the left end of the housing, the first through hole and the second through hole are mutually communicated, the lamp source set 16 is movably disposed in the right end of the first through hole, the convex lens set 15 is disposed in the left end of the first through hole, and the fluorescent filter set 14 is disposed in the second through hole.

Specifically, the right-hand member inner wall of first through-hole is provided with the internal thread, is provided with the external screw thread on the lateral wall of lamp source external member 16, and lamp source external member 16 spiro union is in order to realize the regulatory function of position between the two in the inside of first through-hole.

Specifically, the 15 convex lens suite includes a plurality of convex lenses arranged at intervals inside the first through hole.

Specifically, the fluorescence filter set 14 includes a first filter 20, a second filter 21 and a reflecting mirror 22, the first filter 20 is disposed inside the first through hole and is located at the left side of the convex lens set 15, the second filter 21 is located inside the upper end of the second through hole, and the reflecting mirror 22 is disposed inside the second through hole in an inclined 45 degree manner and is located at the left side of the first filter 20;

the lamp source external member 16 can be at the inside removal of first through-hole, lamp source external member 16 is responsible for producing the light source, convex lens external member 15 is responsible for spotlight, fluorescence filter external member 14 is responsible for filtering the unnecessary light source, through special 45 degrees speculum 22, with light reflection by the lower extreme of second through-hole, when the below reflection comes the light, the light that the reflection comes directly sees through speculum 22, vertically upwards by the upper end of second through-hole, realize the turning to the light path, the fluorescence unit 3 of different independence, inside fluorescence filter external member 14, convex lens external member 15, the main function piece selection type parameter of lamp source external member 16 is inconsistent, thereby reach the purpose that realizes producing the light of different wave bands.

The utility model also provides fluorescence microscopy equipment, which is characterized by comprising the fluorescence module for fluorescence microscopy equipment, further comprising a camera 23, a lens 24 and a slide seat 25, wherein a slide 26 is arranged on the slide seat 25, the camera 23, the fluorescence module, the lens 24 and the slide 26 are sequentially arranged from top to bottom, and the central lines of the reflecting mirror 22 and the lens 24 are positioned on the same straight line along the longitudinal direction.

When the fluorescence microscopy equipment works, a patient sample slide is placed under the lens 24, the slide seat 25 can move in the X and Y directions, the lens 24 can move in the Z axis, the fluorescence unit 3 is driven by the motor 7, the physical center of the reflecting mirror 22 and the center of the lens 24 are collinear, light reflected by the slide sample vertically passes through the reflecting mirror 22 and directly returns to the camera assembly, the camera assembly realizes light path steering through the internal 45-degree reflecting mirror, and the physical center of the reflecting mirror in the camera and the center of the reflecting mirror 24 in the lens and the center of the reflecting mirror 22 in the fluorescence unit 3 are arranged in a collinear manner, so that images can be transmitted to the camera 23, sample and retrograde photographing operation can be realized, and an effective slice image can be provided for the following diagnostic analysis.

The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

The foregoing examples illustrate only a few embodiments of the utility model and are described in detail herein without thereby limiting the scope of the utility model. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the utility model, which are all within the scope of the utility model. Accordingly, the scope of protection of the present utility model is to be determined by the appended claims.

Claims

1. The fluorescent module for the fluorescent microscopic equipment is characterized by comprising a bottom plate, wherein a fluorescent unit mounting plate is movably arranged on one side of the bottom plate, a plurality of fluorescent units are arranged side by side on one end of the fluorescent unit mounting plate, which is far away from the bottom plate, and the fluorescent units are connected with the fluorescent unit mounting plate in a detachable mode.

2. The fluorescence module for fluorescence microscopy equipment according to claim 1, wherein a slide rail is provided on the base plate, a slide block is provided on the slide rail, one end of the fluorescence unit mounting plate, which is far away from the fluorescence unit, is connected with the slide block, a connecting plate is provided on the fluorescence unit mounting plate, a motor is provided on the base plate, and a main shaft of the motor penetrates through the connecting plate and is in threaded connection with the connecting plate.

3. The fluorescence module for fluorescence microscopy equipment according to claim 2, wherein a motor support and a bearing seat are arranged on the bottom plate, the motor is arranged on the motor support, and a main shaft of the motor sequentially penetrates through the motor support and the connecting plate and is inserted into the bearing seat.

4. The fluorescence module for fluorescence microscopy equipment according to claim 3, wherein a photoelectric sensor is arranged on the motor support, an induction notch is arranged at the upper end of the photoelectric sensor, an induction plate is arranged on the connecting plate, and a limit screw is arranged on one side, close to the connecting plate, of the bearing seat.

5. The fluorescence module for fluorescence microscopy equipment according to claim 1, wherein the longitudinal section of the fluorescence unit mounting plate is in an L shape, a plurality of clamping grooves are arranged side by side on the lower end face of the fluorescence unit mounting plate, and a plurality of fluorescence units are correspondingly installed in the clamping grooves through screws.

6. The fluorescence module for a fluorescence microscopy apparatus according to claim 1, wherein the fluorescence unit comprises a fluorescence filter kit, a convex lens kit, a lamp source kit and a housing, wherein a first transverse through hole is provided in the right end of the housing, a second longitudinal through hole is provided in the left end of the housing, the first through hole and the second through hole are communicated with each other, the lamp source kit is movably provided in the right end of the first through hole, the convex lens kit is provided in the left end of the first through hole, and the fluorescence filter kit is provided in the second through hole.

7. The fluorescence module for a fluorescence microscopy apparatus according to claim 6, wherein the right end inner wall of the first through hole is provided with an internal thread, the outer side wall of the lamp source kit is provided with an external thread, and the lamp source kit is screwed inside the first through hole.

8. The fluorescence module for a fluorescence microscopy device of claim 7, wherein the convex lens kit comprises a plurality of convex lenses spaced apart inside the first through hole.

9. The fluorescence module for a fluorescence microscopy apparatus according to claim 8, wherein the fluorescence filter kit comprises a first filter, a second filter and a mirror, the first filter is disposed inside the first through hole and is located at the left side of the convex lens kit, the second filter is located inside the upper end of the second through hole, and the mirror is disposed inside the second through hole with an inclination of 45 degrees and is located at the left side of the first filter.

10. A fluorescence microscopy apparatus comprising a fluorescence module for a fluorescence microscopy apparatus according to claim 9, further comprising a camera, a lens and a slide holder, wherein a slide is arranged on the slide holder, the camera, the fluorescence module, the lens and the slide are arranged in sequence from top to bottom, and the central lines of the reflector and the lens are positioned on the same straight line along the longitudinal direction.