CN219758166U

CN219758166U - Online enrichment treatment system

Info

Publication number: CN219758166U
Application number: CN202223435501.1U
Authority: CN
Inventors: 刘艳; 王建凤; 冯月超; 祖文川; 吴赞; 陈婷; 姜其立
Original assignee: Analysis And Testing Institute Of Beijing Academy Of Science And Technology Beijing Physical And Chemical Analysis And Testing Center
Current assignee: Analysis And Testing Institute Of Beijing Academy Of Science And Technology Beijing Physical And Chemical Analysis And Testing Center
Priority date: 2022-12-21
Filing date: 2022-12-21
Publication date: 2023-09-26
Anticipated expiration: 2032-12-21

Abstract

The utility model relates to the technical field of pollutant detection and provides an online enrichment treatment system which comprises two pump bodies, a first six-way valve, a second six-way valve and an enrichment column, wherein the first six-way valve is connected with the pump bodies; the first six-way valve is in fluid communication with the second six-way valve, one pump body is in fluid communication with the first six-way valve, the other pump body is in fluid communication with the second six-way valve, and both the inlet end and the outlet end of the enrichment column are in fluid communication with the second six-way valve; a quantitative ring is arranged between two interfaces of the first six-way valve, the first six-way valve is switched to a first state, the second six-way valve is correspondingly positioned at a first position, and samples are injected into the quantitative ring; the first six-way valve is switched to a second state, the second six-way valve is correspondingly positioned at a second position, and a pump body conveys a mobile phase to wash the quantitative ring so as to enrich the sample to the enrichment column; the state of the first six-way valve is kept unchanged, the second six-way valve is correspondingly positioned at the first position, and the other pump body is used for conveying eluent to elute the enrichment column so as to perform on-line measurement, so that small sample quantity detection is realized.

Description

Online enrichment treatment system

Technical Field

The utility model relates to the technical field of pollutant detection, in particular to an online enrichment treatment system

Background

With the development of industries such as mining, metallurgy and the like, a large amount of industrial wastewater related to pollutants is discharged into a water environment, and regional environmental water bodies are polluted by pollutants. And the pollutants can be remarkably enriched in human tissues and organs through a food chain, and when the intake of the human pollutants exceeds a certain limit value, the intake of the human pollutants can cause great harm to life and health. Therefore, the development of daily monitoring of pollutants in environmental water bodies is significant.

Because the pollutant content in the environmental water is lower, in order to meet the requirement of detection limit, the detection is carried out after the concentration of the low-concentration pollutant solution is enriched, generally, an adsorption material with a pollutant adsorption function is filled into a column to form an enrichment column, when the low-concentration pollutant solution flows through the enrichment column, the pollutant is adsorbed by the adsorption material, and then a small amount of eluent is used for eluting the pollutant element on the adsorption material, so that the pollutant solution with higher concentration is obtained, and the detection is realized.

However, the existing device of the online enrichment system has more components and complex structure, does not form an integrated controllable device, and cannot accurately detect small sample quantity.

In view of this, the present utility model has been proposed.

Disclosure of Invention

The utility model provides an online enrichment treatment system which is used for solving the defects that the device structure of the online enrichment system is complex and the detection accuracy of small sample size is low in the prior art and realizing the online enrichment accurate detection of the small sample size.

The utility model provides an on-line enrichment treatment system which comprises two pump bodies, a first six-way valve, a second six-way valve and an enrichment column;

the first six-way valve and the second six-way valve are in fluid communication, one pump body is in fluid communication with the first six-way valve, the other pump body is in fluid communication with the second six-way valve, and both the inlet end and the outlet end of the enrichment column are in fluid communication with the second six-way valve;

a quantitative ring is arranged between two interfaces of the first six-way valve, and when the first six-way valve is switched to a first state and the second six-way valve is correspondingly positioned at a first position, a sample is injected to the quantitative ring; when the first six-way valve is switched to a second state, and the second six-way valve is correspondingly positioned at a second position, a pump body in fluid communication with the first six-way valve conveys a mobile phase to flush the quantifying ring, so that a sample is enriched to the enriching column; and when the state of the first six-way valve is kept unchanged and the second six-way valve is correspondingly positioned at the first position, a pump body in fluid communication with the second six-way valve conveys eluent to elute the enrichment column for online measurement.

According to the on-line enrichment treatment system provided by the utility model, the 1# interface of the first six-way valve is connected with the sample injection equipment, and the 2# interface is connected with the waste liquid;

when the first six-way valve is switched to a first state, a 6# interface of the first six-way valve is communicated with a 1# interface, a 3# interface is communicated with a 2# interface, the quantitative ring is arranged between the 3# interface and the 6# interface, a 5# interface is communicated with one pump body, and a 4# interface is communicated with the second six-way valve;

when the first six-way valve is switched to a second state, a 6# interface of the first six-way valve is communicated with a 5# interface, a 3# interface is communicated with a 4# interface, a 1# interface is communicated with a 2# interface, the quantitative ring is arranged between the 3# interface and the 6# interface, the 5# interface is communicated with one of the pump bodies, and the 4# interface is communicated with the second six-way valve.

According to the on-line enrichment treatment system provided by the utility model, the 6# interface of the second six-way valve is communicated with the first six-way valve, the 5# interface is connected with the waste liquid, and the 2# interface is connected with the detection equipment;

when the second six-way valve is switched to a first state, a 1# interface of the second six-way valve is communicated with a 6# interface, a 4# interface is communicated with a 5# interface, the enrichment column is arranged between the 1# interface and the 4# interface, a 3# interface is communicated with the other pump body, and a 2# interface is communicated with the 3# interface;

When the second six-way valve is switched to a second state, a 1# interface of the second six-way valve is communicated with a 2# interface, a 3# interface is communicated with a 4# interface, the enrichment column is arranged between the 1# interface and the 4# interface, the 3# interface is communicated with the other pump body, and the 5# interface is communicated with the 6# interface.

The utility model also provides an online enrichment treatment system which comprises two pump bodies, a first six-way valve, a second six-way valve, a third six-way valve, a first enrichment column and a second enrichment column;

the first six-way valve and the second six-way valve, wherein one pump body is in fluid communication with the first six-way valve, wherein the other pump body is in fluid communication with the third six-way valve, the inlet end of the first enrichment column is in fluid communication with the third six-way valve, the outlet end of the first enrichment column is in fluid communication with the second six-way valve, the inlet end of the second enrichment column is in fluid communication with the second six-way valve, and the outlet end of the second enrichment column is in fluid communication with the third six-way valve;

when the second six-way valve is positioned at a first position and the third six-way valve is positioned at a third position, a pump body in fluid communication with the first six-way valve conveys a second sample to be enriched to the second enrichment column, and a pump body in fluid communication with the third six-way valve conveys an eluent to elute a first sample of the first enrichment column for on-line measurement;

And when the second six-way valve is positioned at the second position and the third six-way valve is positioned at the fourth position, the pump body in fluid communication with the first six-way valve conveys a first sample to be enriched to the first enrichment column, and the pump body in fluid communication with the third six-way valve conveys an eluent to elute a second sample of the second enrichment column for on-line measurement.

According to the online enrichment treatment system provided by the utility model, a quantitative ring is arranged between two interfaces of the first six-way valve;

when the first six-way valve is switched to a first state, the second six-way valve is correspondingly positioned at a first position, and the third six-way valve is correspondingly positioned at a third position, sample is injected to the quantitative ring;

when the first six-way valve is switched to a second state, and the second six-way valve is correspondingly positioned at a second position, and the third six-way valve is correspondingly positioned at a fourth position, a pump body in fluid communication with the first six-way valve conveys a mobile phase to wash the quantitative ring, so that a sample is enriched to the first enrichment column;

when the first six-way valve is switched to a first state, the second six-way valve is correspondingly positioned at a first position, and when the third six-way valve is correspondingly positioned at a third position, a pump body which is in fluid communication with the second six-way valve conveys eluent to elute the first enrichment column so as to perform online measurement, and meanwhile, a second sample is injected into a quantitative ring;

When the first six-way valve is switched to a second state, and the second six-way valve is correspondingly positioned at a first position, and the third six-way valve is correspondingly positioned at a third position, a pump body in fluid communication with the first six-way valve conveys a mobile phase to wash the quantitative ring, so that a second sample is enriched to the second enrichment column;

and when the state of the first six-way valve is kept unchanged and the second six-way valve is correspondingly positioned at the second position, and when the third six-way valve is correspondingly positioned at the fourth position, the pump body conveying mobile phase in fluid communication with the first six-way valve washes the quantitative ring, so that the first sample is enriched to the first enrichment column, and the pump body conveying eluent in fluid communication with the third six-way valve elutes the second enrichment column for online measurement.

According to the on-line enrichment treatment system provided by the utility model, the No. 5 interface of the two six-way valve is communicated with the first six-way valve, and the No. 2 interface is connected with the detection equipment;

when the second six-way valve is positioned at the first position, a 6# interface of the second six-way valve is communicated with a 5# interface, a 4# interface is communicated with a 6# interface, a 3# interface is communicated with a 4# interface, a 2# interface is communicated with a 1# interface, an inlet end of the second enrichment column is communicated with the 3# interface of the second six-way valve, an outlet end of the second enrichment column is communicated with the third six-way valve, and the 1# interface is communicated with an outlet end of the first enrichment column;

when the second six-way valve is positioned at the second position, a 1# interface of the second six-way valve is communicated with a 6# interface, the 6# interface is communicated with a 4# interface, the 4# interface is communicated with a 5# interface, the 2# interface is communicated with a 3# interface, the outlet end of the second enrichment column is communicated with the 3# interface of the second six-way valve, the inlet end of the second enrichment column is communicated with the third six-way valve, and the 1# interface is communicated with the inlet end of the first enrichment column.

According to the on-line enrichment treatment system provided by the utility model, the No. 2 interface of the third six-way valve is communicated with one pump body, and the No. 5 interface is connected with waste liquid;

when the third six-way valve is positioned at a third position, a 1# interface of the third six-way valve is communicated with a 2# interface, a 3# interface is communicated with a 4# interface, the 4# interface is communicated with a 6# interface, the 6# interface is communicated with a 5# interface, an outlet end of the second enrichment column is communicated with the 3# interface, and an inlet end of the first enrichment column is communicated with the 1# interface;

when the third six-way valve is positioned at the fourth position, a 2# interface of the third six-way valve is communicated with a 3# interface, a 1# interface is communicated with a 6# interface, a 6# interface is communicated with a 4# interface, a 4# interface is communicated with a 5# interface, an inlet end of the second enrichment column is communicated with the 3# interface, and an outlet end of the first enrichment column is communicated with the 1# interface.

According to the online enrichment treatment system provided by the utility model, the quantitative ring is arranged between the two interfaces of the first six-way valve, when the first six-way valve is switched to the first state and the second six-way valve is correspondingly positioned at the first position, the sample is injected into the quantitative ring, the quantitative ring can accurately quantify the sample quantity, and the accurate quantity is realized, so that the online enrichment treatment system can accurately detect the online enrichment of the small sample quantity.

Compared with the prior art, the on-line enrichment treatment system provided by the utility model also switches the first state and the second state of the first six-way valve, switches the first position and the second position of the second six-way valve, and realizes on-line elution and enrichment detection by communicating the two six-way valves, and has a simple structure.

Drawings

In order to more clearly illustrate the utility model or the technical solutions of the prior art, the following description will briefly explain the drawings used in the embodiments or the description of the prior art, and it is obvious that the drawings in the following description are some embodiments of the utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of the on-line enrichment processing system according to embodiment 1 of the present utility model in a first state;

FIG. 2 is a schematic diagram of the on-line enrichment processing system according to embodiment 1 of the present utility model in a second state;

FIG. 3 is a schematic diagram of the on-line enrichment processing system according to embodiment 1 of the present utility model in a third state;

FIG. 4 is a schematic diagram of a second six-way valve of the on-line enrichment processing system according to embodiment 2 of the present utility model in a first position;

FIG. 5 is a schematic diagram of a second six-way valve of the on-line enrichment processing system according to embodiment 2 of the present utility model in a second position;

FIG. 6 is a schematic diagram of the structure of the second six-way valve and the third six-way valve of the on-line enrichment treatment system according to embodiment 3 of the present utility model in the first position and the third position respectively;

FIG. 7 is a schematic diagram of the on-line enrichment processing system according to embodiment 3 of the present utility model, wherein the second six-way valve is located at the second position and the third six-way valve is located at the fourth position;

FIG. 8 is a schematic diagram of the configuration of the first six-way valve in the first position, the second six-way valve in the third position, and the third six-way valve in the fifth position of the on-line enrichment processing system provided in example 4 of the present utility model;

FIG. 9 is a schematic diagram of the on-line enrichment treatment system according to embodiment 4 of the present utility model, wherein the first six-way valve is located at the second position, the second six-way valve is located at the fourth position, and the third six-way valve is located at the sixth position;

FIG. 10 is a schematic diagram of the configuration of the first six-way valve in the first position, the second six-way valve in the third position, and the third six-way valve in the fifth position of the on-line enrichment processing system provided in example 4 of the present utility model;

FIG. 11 is a schematic diagram showing the structure of the on-line enrichment treatment system according to embodiment 4 of the present utility model, wherein the first six-way valve is located at the second position, the second six-way valve is located at the third position, and the third six-way valve is located at the fifth position;

FIG. 12 is a schematic diagram showing the structure of the on-line enrichment treatment system according to embodiment 4 of the present utility model, wherein the first six-way valve is located at the second position, the second six-way valve is located at the fourth position, and the third six-way valve is located at the sixth position;

FIG. 13 is one of the schematic block diagrams of the controller of the on-line enrichment processing system provided by the present utility model;

FIG. 14 is a diagram of a second embodiment of the controller principle of the on-line enrichment processing system provided by the present utility model.

Reference numerals:

100. a first pump body; 200. a second pump body; 300. a first six-way valve;

400. a second six-way valve; 500. a first enrichment column; 600. a dosing ring;

700. a third six-way valve; 800. a second enrichment column;

11. a programmable logic controller; 111. a power module; 112. a central processing unit; 113. a storage module; 114. an input module; 115. an output module; 116. and a peripheral interface module.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the present utility model more apparent, the technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present utility model, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

In describing embodiments of the present utility model, it should be noted that, unless explicitly stated and limited otherwise, the terms "coupled," "coupled," and "connected" should be construed broadly, and may be either a fixed connection, a removable connection, or an integral connection, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium. The specific meaning of the above terms in embodiments of the present utility model will be understood in detail by those of ordinary skill in the art.

In embodiments of the utility model, unless expressly specified and limited otherwise, a first feature "up" or "down" on a second feature may be that the first and second features are in direct contact, or that the first and second features are in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.

In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the embodiments of the present utility model. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.

Embodiments of the present utility model are described below with reference to fig. 1 to 14. It should be understood that the following description is only illustrative of embodiments of the utility model and is not intended to limit the utility model in any way.

Example 1

Referring to fig. 1 to 3, the on-line enrichment processing system includes a first pump body 100, a second pump body 200, a first six-way valve 300, a second six-way valve 400, and a first enrichment column 500, wherein the first pump body 100 and the second pump body 200 are high-pressure pumps;

The first pump body 100 is in fluid communication with the first six-way valve 300, the second pump body 200 is in fluid communication with the second six-way valve 400, the first six-way valve 300 is in fluid communication with the second six-way valve 400, and both the inlet end and the outlet end of the first enrichment column 500 are in fluid communication with the second six-way valve 400;

wherein a dosing ring 600 is provided between two interfaces of the first six-way valve 300, the first six-way valve 300 being adapted to switch between a first state and a second state, the second six-way valve 400 being adapted to switch between a first position and a second position.

In the first state, as shown in fig. 1, the 1# port of the first six-way valve 300 is connected to the 6# port, the 2# port is connected to the 3# port, the 4# port is connected to the 5# port, and the dosing ring 600 is connected between the 3# port and the 6# port.

At this time, the second six-way valve 400 is correspondingly at the first position, the 1# interface of the second six-way valve 400 is communicated with the 2# interface, the 3# interface is communicated with the 4# interface, and the 5# interface is communicated with the 6# interface.

In the second state, as shown in fig. 2, the 1# port of the first six-way valve 300 communicates with the 2# port, the 3# port communicates with the 4# port, the 5# port communicates with the 6# port, and the dosing ring 600 is connected between the 3# port and the 6# port.

At this time, the second six-way valve 400 is correspondingly in the second position, the 1# interface of the second six-way valve 400 is communicated with the 6# interface, the 2# interface is communicated with the 3# interface, and the 4# interface is communicated with the 5# interface.

Referring to fig. 1, specifically, when the first six-way valve 300 switches to the first state, the 1# interface of the first six-way valve 300 is connected to the sample injection device, and the 2# interface of the first six-way valve 300 is connected to the waste liquid; the 6# interface of the first six-way valve 300 is communicated with the 1# interface of the first six-way valve 300, and the 5# interface of the first six-way valve 300 is communicated with the first pump body 100; the 3# interface of the first six-way valve 300 is communicated with the 2# interface of the first six-way valve 300, the quantitative ring 600 is arranged between the 3# interface of the first six-way valve 300 and the 6# interface of the first six-way valve 300, samples can enter from the 1# interface of the first six-way valve 300 and enter the quantitative ring 600 through the 6# interface for quantitative sample injection, the quantitative ring 600 can accurately sample, and the quantitative ring is suitable for sample sampling with the sample volume smaller than 15 ml.

Correspondingly, the second six-way valve 400 is located at the first position, the 6# interface of the second six-way valve 400 is communicated with the 5# interface of the second six-way valve 400, the 5# interface of the second six-way valve 400 is connected with the waste liquid, and the 6# interface of the second six-way valve 400 is communicated with the 4# interface of the first six-way valve 300. In the first state, neither the first pump body 100 nor the second pump body 200 is operated.

Referring to fig. 2, the first six-way valve 300 is switched to be in the second state, the second pump body 200 is not operated, the 1# interface of the first six-way valve 300 is connected with the sample injection device, the 2# interface of the first six-way valve 300 is connected with the waste liquid, the 1# interface of the first six-way valve 300 is communicated with the 2# interface of the first six-way valve 300, the 6# interface of the first six-way valve 300 is communicated with the 5# interface of the first six-way valve 300, the 3# interface of the first six-way valve 300 is communicated with the 4# interface of the first six-way valve 300, the dosing ring 600 is arranged between the 3# interface of the first six-way valve 300 and the 6# interface of the first six-way valve 300, the 5# interface of the first six-way valve 300 is communicated with the first pump body 100, and the 4# interface of the first six-way valve 300 is communicated with the 6# interface of the second six-way valve 400, so that the first pump body 100 can deliver the mobile phase to flush the dosing ring 600, and enrich the sample to the first enriching column 500.

Correspondingly, the second six-way valve 400 is located at the second position, the 1# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 is communicated with the 5# interface of the second six-way valve 400, the first enriching column 500 is arranged between the 1# interface of the second six-way valve 400 and the 4# interface of the second six-way valve 400, the 3# interface of the second six-way valve 400 is communicated with the second pump body 200, the 2# interface of the second six-way valve 400 is communicated with the 3# interface of the second six-way valve 400, and the 2# interface of the second six-way valve 400 is connected with the detection equipment.

In the second state, after the first pump body 100 conveys the mobile phase to flush the dosing ring 600, fluid flows into the inflow end of the first enrichment column 500 through the 6# interface of the second six-way valve 400 and the 1# interface of the second six-way valve 400, is enriched through the first enrichment column 500, flows into the 4# interface of the second six-way valve 400 from the outflow end of the first enrichment column 500, and finally discharges waste liquid through the 5# interface of the second six-way valve 400, thereby completing enrichment of the sample.

Referring to fig. 3, the first six-way valve 300 is maintained in the second state, and accordingly, the second six-way valve 400 is located in the first position. The first pump body 100 does not work, the 1# interface of the second six-way valve 400 is communicated with the 2# interface of the second six-way valve 400, the 3# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, the first enriching column 500 is arranged between the 1# interface of the second six-way valve 400 and the 4# interface of the second six-way valve 400, the 3# interface of the second six-way valve 400 is communicated with the second pump body 200, the 2# interface of the second six-way valve 400 is connected with a detection device, and the 5# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400.

In the second state, the second pump body 200 delivers the eluent to flush the first enrichment column 500, the fluid flows into the inflow end of the first enrichment column 500 through the 3# interface of the second six-way valve 400 and the 4# interface of the second six-way valve 400, after eluting the sample enriched in the first enrichment column 500, the fluid flows into the 1# interface of the second six-way valve 400 from the outflow end of the first enrichment column 500, and finally flows into the detection device through the 2# interface of the second six-way valve 400, so that the elution and the on-line detection of the sample are completed.

Based on the online enrichment processing system, the utility model also provides an application method of the online enrichment processing system, which comprises the following steps:

sample is introduced into the dosing ring 600 through the first six-way valve 300;

actuating a pump body in fluid communication with the first six-way valve 300 to deliver a mobile phase to flush the dosing ring 600 to enrich the sample to the enrichment column 500;

a pump body in fluid communication with the second six-way valve 400 is actuated to deliver an eluent to elute the enrichment column 500 and perform an on-line test suitable for on-line testing of samples having a sample size of less than 15 ml.

Compared with the online enrichment processing system in the prior art, the online enrichment processing system structure disclosed by the utility model has the advantages that the first six-way valve 300 is switched between the first state and the second state, the second six-way valve 400 is switched between the first position and the second position, and three states of the online enrichment processing system are formed, so that accurate quantitative sample injection of a small sample is realized, online enrichment and elution detection are realized, and the structure is simple.

Example 2

Referring to fig. 4-5, in some embodiments of the present utility model, an in-line enrichment processing system includes a first pump body 100, a second pump body 200, a first six-way valve 300, a second six-way valve 400, a third six-way valve 700, a first enrichment column 500;

referring to fig. 4, when the first and third six-way valves 300 and 700 are not operated, the 5# interface of the second six-way valve 400 is connected to the waste liquid, the first pump body 100 is connected to the 6# interface of the second six-way valve 400, the 1# interface of the second six-way valve 400 is connected to the 6# interface of the second six-way valve 400, the 2# interface of the second six-way valve 400 is connected to the 3# interface of the second six-way valve 400, the second pump body 200 is connected to the 3# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 is connected to the 5# interface of the second six-way valve 400, one end of the first enriching column 500 is connected to the 1# interface of the second six-way valve 400, the other end of the first enriching column 500 is connected to the 4# interface of the second six-way valve 400, the first pump body 100 is started, and the sample flows out to the first enriching column 500 through the 6# interface and the 1# interface of the second six-way valve 400, and the waste liquid flows out through the 4# interface of the second six-way valve 400.

Referring to fig. 5, when the first six-way valve 300 and the third six-way valve 700 do not operate, the second six-way valve 400 is located at the second position, the 1# interface of the second six-way valve 400 is communicated with the 2# interface of the second six-way valve 400, the 3# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, the 5# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, the first pump body 100 is connected with the 6# interface of the second six-way valve 400, the 5# interface of the second six-way valve 400 is connected with waste liquid, the 2# interface of the second six-way valve 400 is connected with the detection device, the second pump body 200 is connected with the 3# interface of the second six-way valve 400, one end of the first enriching column 500 is connected with the 4# interface of the second six-way valve 400, the other end of the first enriching column 500 is connected with the 1# interface of the second six-way valve 400, the second pump body 200 is started, the pumped eluent flows into the first enriching column 500 through the 3# interface of the second six-way valve 400 and the 4# interface of the first enriching column 500, and the second eluting column 1 is detected through the detection device. The embodiment can complete on-line detection by using one six-way valve, is suitable for enrichment of a single sample and is suitable for a large-volume sample.

Example 3

Referring to fig. 6 to 7, the on-line enrichment treatment system includes a first pump body 100, a second pump body 200, a first six-way valve 300, a second six-way valve 400, a third six-way valve 700, a first enrichment column 500, and a second enrichment column 800;

the first pump body 100 is in fluid communication with the first six-way valve 300, the second pump body 200 is in fluid communication with the third six-way valve 700, the first six-way valve 300 is in fluid communication with the second six-way valve 400, the two ends of the first enrichment column 500 are in fluid communication with the second six-way valve 400 and the third six-way valve 700, respectively, and the two ends of the second enrichment column 800 are in fluid communication with the second six-way valve 400 and the third six-way valve 700, respectively;

wherein the first six-way valve 300 is position invariant, the second six-way valve 400 is adapted to switch between a first position and a second position, and the third six-way valve 700 is adapted to switch between a third position and a fourth position;

referring to fig. 6, the position of the first six-way valve 300 is unchanged, the second six-way valve 400 is located at the first position, the third six-way valve 700 is located at the third position, the first pump body 100 delivers the mobile phase to pass through the first six-way valve 300 and the second six-way valve 400 and then washes the second enrichment column 800, so that the sample is enriched in the second enrichment column 800, and simultaneously, the second pump body 200 delivers the eluent to pass through the third six-way valve 700 and then elutes the eluted first enrichment column 500, so as to complete the on-line detection.

Referring to fig. 7, the position of the first six-way valve 300 is unchanged, the second six-way valve 400 is located at the second position, the third six-way valve 700 is located at the fourth position, the first pump body 100 delivers the mobile phase to pass through the first six-way valve 300 and the second six-way valve 400 and then washes the first enrichment column 500, so that the sample is enriched in the first enrichment column 500, and simultaneously, the second pump body 200 delivers the eluent to pass through the third six-way valve 700 and then elutes the eluted second enrichment column 800, so as to complete the on-line detection.

In this embodiment, the positions of the first six-way valve 300 are unchanged, the positions of the second six-way valve 400 and the third six-way valve 700 are variable, so that online enrichment detection of two samples can be realized, quantitative loop sample injection is not required, and the method is suitable for large-volume samples.

It will be appreciated that referring to fig. 6, the position of the first six-way valve 300 is unchanged, the second six-way valve 400 is located at the first position, the 1# interface of the first six-way valve 300 is communicated with the 6# interface of the first six-way valve 300, the 2# interface of the first six-way valve 300 is communicated with the 3# interface of the first six-way valve 300, the two ends of the dosing ring 600 are respectively connected with the 3# interface and the 6# interface of the first six-way valve 300, the 4# interface of the first six-way valve 300 is communicated with the 5# interface of the first six-way valve 300, the 5# interface of the first six-way valve 300 is communicated with the first pump body 100, the 4# interface of the first six-way valve 300 is communicated with the 5# interface of the second six-way valve 400, the 6# interface of the second six-way valve 400 is communicated with the 5# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, the 3# of the second six-way valve 400 is communicated with the 4# of the second six-way valve 400, the 3# interface of the second six-way valve 400 is connected with the inlet end of the second enriching column 800, the outlet end of the second enriching column 800 is connected with the 3# interface of the third six-way valve 700, the 4# interface of the third six-way valve 700 is communicated with the 3# interface of the third six-way valve 700, the 6# interface of the third six-way valve 700 is communicated with the 4# interface of the third six-way valve 700, the 5# interface of the third six-way valve 700 is communicated with the 6# interface of the third six-way valve 700, the 5# interface of the third six-way valve 700 is connected with the waste liquid, the 2# interface of the third six-way valve 700 is connected with the second pump body 200, the 1# interface of the third six-way valve 700 is communicated with the 2# interface of the third six-way valve 700, the inlet end of the first enriching column 500 is connected with the 1# interface of the third six-way valve 700, the outlet end of the first enriching column 500 is connected with the 1# interface of the second six-way valve 400, the 2# interface of the second six-way valve 400 is communicated with the 1# interface of the second six-way valve 400, and the 2# interface of the second six-way valve 400 is connected with a detection device.

The mobile phase is conveyed by the first pump body 100, flows into the 5# interface of the second six-way valve 400 through the 5# interface of the first six-way valve 300 and the 4# interface of the first six-way valve 300, flows into the second enriching column 800 after flowing into the 6# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 and the 3# interface of the second six-way valve 400, so that the sample is enriched to the second enriching column 800, and the waste liquid flows into the 3# interface of the third six-way valve 700, the 4# interface of the third six-way valve 700, the 6# interface of the third six-way valve 700 and the 5# interface of the third six-way valve 700 through the outlet end of the second enriching column 800, and finally flows into the waste liquid treatment.

The second pump body 200 conveys the eluent to flow into the first enrichment column 500 through the No. 2 interface of the third six-way valve 700 and the No. 1 interface of the third six-way valve 700, elutes the first enrichment column 500, and the eluent flows to the No. 1 interface of the second six-way valve 400 and the No. 2 interface of the second six-way valve 400 to finish online detection.

Referring to fig. 7, the position of the first six-way valve 300 is unchanged, the second six-way valve 400 is located at the second position, the third six-way valve 700 is located at the fourth position, the 1# interface of the first six-way valve 300 is communicated with the 6# interface of the first six-way valve 300, the 2# interface of the first six-way valve 300 is communicated with the 3# interface of the first six-way valve 300, the two ends of the dosing ring 600 are respectively connected with the 3# interface and the 6# interface of the first six-way valve 300, the 4# interface of the first six-way valve 300 is communicated with the 5# interface of the first six-way valve 300, the 5# interface of the first six-way valve 300 is communicated with the first pump body 100, the 4# interface of the first six-way valve 300 is communicated with the 5# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 is communicated with the 5# interface of the second six-way valve 400, the 6# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, the 1# of the second six-way valve 400 is communicated with the 6# of the second six-way valve 400, the 2# interface of the second six-way valve 400 is communicated with the 3# interface of the second six-way valve 400, the 1# interface of the second six-way valve 400 is connected with the inlet end of the first enriching column 500, the outlet end of the first enriching column 500 is connected with the 1# interface of the third six-way valve 700, the 6# interface of the third six-way valve 700 is communicated with the 1# interface of the third six-way valve 700, the 4# interface of the third six-way valve 700 is communicated with the 6# interface of the third six-way valve 700, the 5# interface of the third six-way valve 700 is communicated with the 4# interface of the third six-way valve 700, the 5# interface of the third six-way valve 700 is connected with the waste liquid, the 2# interface of the third six-way valve 700 is connected with the second pump body 200, the 3# interface of the third six-way valve 700 is communicated with the 2# interface of the third six-way valve 700, the inlet end of the second enriching column is connected with the 3# interface of the third six-way valve 700, the outlet end of the second enrichment column 800 is connected with the 3# interface of the second six-way valve 400, and the 2# interface of the second six-way valve 400 is connected with a detection device.

The mobile phase is conveyed by the first pump body 100, flows into the 5# interface of the second six-way valve 400 through the 5# interface of the first six-way valve 300 and the 4# interface of the first six-way valve 300, flows into the first enriching column 500 after flowing into the 4# interface of the second six-way valve 400, the 6# interface of the second six-way valve 400 and the 1# interface of the second six-way valve 400, so that the sample is enriched to the first enriching column 500, and the waste liquid flows into the 1# interface of the third six-way valve 700, the 6# interface of the third six-way valve 700, the 4# interface of the third six-way valve 700 and the 5# interface of the third six-way valve 700 through the outlet end of the first enriching column 500, and finally flows into the waste liquid treatment.

The second pump body 200 conveys the eluent to flow into the second enrichment column 800 through the No. 2 interface of the third six-way valve 700 and the No. 3 interface of the third six-way valve 700, elutes the second enrichment column 800, and the eluent flows to the No. 3 interface of the second six-way valve 400 and the No. 2 interface of the second six-way valve 400 to finish online detection.

Example 4

Referring to fig. 8 to 12, the on-line enrichment treatment system includes a first pump body 100, a second pump body 200, a first six-way valve 300, a second six-way valve 400, a third six-way valve 700, a first enrichment column 500, and a second enrichment column 800;

the first pump body 100 is in fluid communication with the first six-way valve 300, the second pump body 200 is in fluid communication with the third six-way valve 700, the first six-way valve 300 is in fluid communication with the second six-way valve 400, the inlet end of the first enrichment column 500 is in fluid communication with the third six-way valve 700, the outlet end of the first enrichment column 500 is in fluid communication with the second six-way valve 400, the inlet end of the second enrichment column 800 is in fluid communication with the second six-way valve 400, and the outlet end of the second enrichment column 800 is in fluid communication with the third six-way valve 700;

Wherein a dosing ring 600 is provided between the two interfaces of the first six-way valve 300, the first six-way valve 300 being adapted to switch between a first position and a second position, the second six-way valve 400 being adapted to switch between a third position and a fourth position, the third six-way valve 700 being adapted to switch between a fifth position and a sixth position;

referring to fig. 8, the first six-way valve 300 is located at the first position, the second six-way valve 400 is located at the third position, the third six-way valve 700 is located at the fifth position, the 1# interface of the first six-way valve 300 is communicated with the 6# interface of the first six-way valve 300, the 2# interface of the first six-way valve 300 is communicated with the 3# interface of the first six-way valve 300, the 4# interface of the first six-way valve 300 is communicated with the 5# interface of the first six-way valve 300, and both ends of the dosing ring 600 are respectively connected with the 3# interface and the 6# interface of the first six-way valve 300; the 1# interface of the second six-way valve 400 is communicated with the 2# interface of the second six-way valve 400, the 3# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, and the 6# interface of the second six-way valve 400 is communicated with the 5# interface of the second six-way valve 400; the 1# interface of the third six-way valve 700 is communicated with the 2# interface of the third six-way valve 700, the 3# interface of the third six-way valve 700 is communicated with the 4# interface of the third six-way valve 700, the 4# interface of the third six-way valve 700 is communicated with the 6# interface of the third six-way valve 700, the 6# interface of the third six-way valve 700 is communicated with the 5# interface of the third six-way valve 700, and the first sample is injected into the dosing ring 600;

Referring to fig. 9, the first six-way valve 300 is located at the second position, the second six-way valve 400 is located at the fourth position, the third six-way valve 700 is located at the sixth position, the 1# interface of the first six-way valve 300 is communicated with the 2# interface of the first six-way valve 300, the 3# interface of the first six-way valve 300 is communicated with the 4# interface of the first six-way valve 300, the 6# interface of the first six-way valve 300 is communicated with the 5# interface of the first six-way valve 300, and both ends of the dosing ring 600 are respectively connected with the 3# interface and the 6# interface of the first six-way valve 300; the 1# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, the 5# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, and the 3# interface of the second six-way valve 400 is communicated with the 2# interface of the second six-way valve 400; the 1# interface of the third six-way valve 700 is communicated with the 6# interface of the third six-way valve 700, the 6# interface of the third six-way valve 700 is communicated with the 4# interface of the third six-way valve 700, the 4# interface of the third six-way valve 700 is communicated with the 5# interface of the third six-way valve 700, the 3# interface of the third six-way valve 700 is communicated with the 2# interface of the third six-way valve 700, and the first pump body 100 conveys the mobile phase flushing dosing ring 600 to enrich the first sample to the first enrichment column 500;

Referring to fig. 10, the first six-way valve 300 is located at the first position, the second six-way valve 400 is located at the third position, the third six-way valve 700 is located at the fifth position, the 1# interface of the first six-way valve 300 is communicated with the 6# interface of the first six-way valve 300, the 2# interface of the first six-way valve 300 is communicated with the 3# interface of the first six-way valve 300, the 4# interface of the first six-way valve 300 is communicated with the 5# interface of the first six-way valve 300, and both ends of the dosing ring 600 are respectively connected with the 3# interface and the 6# interface of the first six-way valve 300; the 1# interface of the second six-way valve 400 is communicated with the 2# interface of the second six-way valve 400, the 3# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, and the 6# interface of the second six-way valve 400 is communicated with the 5# interface of the second six-way valve 400; the 1# interface of the third six-way valve 700 is communicated with the 2# interface of the third six-way valve 700, the 3# interface of the third six-way valve 700 is communicated with the 4# interface of the third six-way valve 700, the 4# interface of the third six-way valve 700 is communicated with the 6# interface of the third six-way valve 700, the 6# interface of the third six-way valve 700 is communicated with the 5# interface of the third six-way valve 700, the second pump body 200 conveys eluent to elute the first enrichment column 500 to realize online measurement, and meanwhile, the second sample is injected into the quantitative ring 600;

Referring to fig. 11, the first six-way valve 300 is located at the second position, the second six-way valve 400 is located at the third position, the third six-way valve 700 is located at the fifth position, the 1# interface of the first six-way valve 300 is communicated with the 2# interface of the first six-way valve 300, the 3# interface of the first six-way valve 300 is communicated with the 4# interface of the first six-way valve 300, the 5# interface of the first six-way valve 300 is communicated with the 6# interface of the first six-way valve 300, and both ends of the dosing ring 600 are respectively connected with the 3# interface and the 6# interface of the first six-way valve 300; the 1# interface of the second six-way valve 400 is communicated with the 2# interface of the second six-way valve 400, the 3# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, and the 6# interface of the second six-way valve 400 is communicated with the 5# interface of the second six-way valve 400; the 1# interface of the third six-way valve 700 is communicated with the 2# interface of the third six-way valve 700, the 3# interface of the third six-way valve 700 is communicated with the 4# interface of the third six-way valve 700, the 4# interface of the third six-way valve 700 is communicated with the 6# interface of the third six-way valve 700, the 6# interface of the third six-way valve 700 is communicated with the 5# interface of the third six-way valve 700, and the first pump body 100 conveys the mobile phase flushing dosing ring 600 to enrich the second sample to the second enrichment column 800;

Referring to fig. 12, the first six-way valve 300 is located at the second position, the second six-way valve 400 is located at the fourth position, the third six-way valve 700 is located at the sixth position, the 1# interface of the first six-way valve 300 is communicated with the 2# interface of the first six-way valve 300, the 3# interface of the first six-way valve 300 is communicated with the 4# interface of the first six-way valve 300, the 6# interface of the first six-way valve 300 is communicated with the 5# interface of the first six-way valve 300, and both ends of the dosing ring 600 are respectively connected with the 3# interface and the 6# interface of the first six-way valve 300; the 1# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, the 5# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, and the 3# interface of the second six-way valve 400 is communicated with the 2# interface of the second six-way valve 400; the port # 1 of the third six-way valve 700 is communicated with the port # 6 of the third six-way valve 700, the port # 6 of the third six-way valve 700 is communicated with the port # 4 of the third six-way valve 700, the port # 4 of the third six-way valve 700 is communicated with the port # 5 of the third six-way valve 700, the port # 3 of the third six-way valve 700 is communicated with the port # 2 of the third six-way valve 700, the second pump body 200 conveys eluent to elute the second enrichment column 800 to achieve on-line measurement, and simultaneously, the first pump body 100 conveys the mobile phase flushing dosing ring 600 to enrich the first sample to the first enrichment column 500.

As can be appreciated, referring to fig. 8 or 10, when the first six-way valve 300 is located at the first position, the 6# interface of the first six-way valve 300 is communicated with the 1# interface of the first six-way valve 300, the 3# interface of the first six-way valve 300 is communicated with the 2# interface of the first six-way valve 300, the dosing ring 600 is arranged between the 3# interface of the first six-way valve 300 and the 6# interface of the first six-way valve 300, the 5# interface of the first six-way valve 300 is communicated with the first pump body 100, the 4# interface of the first six-way valve 300 is communicated with the second six-way valve 400, and the sample is introduced into the dosing ring 600, in this embodiment, the sample can be suitable for a sample with a sample size of less than 15 ml;

referring to fig. 10, when the first six-way valve 300 is in the first position, the second six-way valve 400 is in the third position, and the third six-way valve 700 is in the fifth position; the 5# interface of the second six-way valve 400 is communicated with the 4# interface of the first six-way valve 300, the 6# interface of the second six-way valve 400 is communicated with the 5# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, the 3# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, the 1# interface of the second six-way valve 400 is communicated with the 2# interface of the second six-way valve 400, the 1# interface of the second six-way valve 400 is connected with the outlet end of the first enrichment column 500, the 2# interface of the second six-way valve 400 is connected with a detection device, and the 3# interface of the second six-way valve 400 is connected with the inlet end of the second enrichment column 800; the 1# interface of the third six-way valve 700 is connected with the inlet end of the first enrichment column 500, the 2# interface of the third six-way valve 700 is communicated with the 1# interface of the third six-way valve 700, the 2# interface of the third six-way valve 700 is connected with the second pump body 200, the 3# interface of the third six-way valve 700 is connected with the outlet end of the second enrichment column 800, the 4# interface of the third six-way valve 700 is communicated with the 3# interface of the third six-way valve 700, the 6# interface of the third six-way valve 700 is communicated with the 4# interface of the third six-way valve 700, the 5# interface of the third six-way valve 700 is communicated with the 6# interface of the third six-way valve 700, and the 5# interface of the third six-way valve 700 is connected with waste liquid. The second pump body 200 delivers an eluent to elute the first enrichment column 500 for on-line measurement while the second sample is injected into the dosing ring 600.

Referring to fig. 9 or 11 or 12, when the first six-way valve 300 is located at the second position, the 6# interface of the first six-way valve 300 is communicated with the 5# interface of the first six-way valve 300, the 3# interface of the first six-way valve 300 is communicated with the 4# interface of the first six-way valve 300, the 1# interface of the first six-way valve 300 is communicated with the 2# interface of the first six-way valve 300, the dosing ring 600 is arranged between the 3# interface of the first six-way valve 300 and the 6# interface of the first six-way valve 300, the 5# interface of the first six-way valve 300 is connected with the first pump body 100, and the 4# interface of the first six-way valve 300 is communicated with the second six-way valve 400 to convey the mobile phase flushing dosing ring 600.

Referring to fig. 9, when the first six-way valve 300 is located at the second position, the second six-way valve 400 is located at the fourth position, and the third six-way valve 700 is located at the sixth position; the 5# interface of the second six-way valve 400 is communicated with the 4# interface of the first six-way valve 300, the 4# interface of the second six-way valve 400 is communicated with the 5# interface of the second six-way valve 400, the 6# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, the 1# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, the 2# interface of the second six-way valve 400 is communicated with the 3# interface of the second six-way valve 400, the 1# interface of the second six-way valve 400 is connected with the inlet end of the first enrichment column 500, the 2# interface of the second six-way valve 400 is connected with a detection device, and the 3# interface of the second six-way valve 400 is connected with the outlet end of the second enrichment column 800; the 1# interface of the third six-way valve 700 is connected with the outlet end of the first enrichment column 500, the 6# interface of the third six-way valve 700 is communicated with the 1# interface of the third six-way valve 700, the 4# interface of the third six-way valve 700 is communicated with the 6# interface of the third six-way valve 700, the 5# interface of the third six-way valve 700 is communicated with the 4# interface of the third six-way valve 700, the 2# interface of the third six-way valve 700 is connected with the second pump body 200, the 3# interface of the third six-way valve 700 is connected with the inlet end of the second enrichment column 800, and the 5# interface of the third six-way valve 700 is connected with waste liquid. The first pump body 100 delivers the mobile phase to flush the dosing ring 600, enriching the first sample to the first enrichment column 500.

Referring to fig. 11, when the first six-way valve 300 is located at the second position, the second six-way valve 400 is located at the third position, and the third six-way valve 700 is located at the fifth position; the 5# interface of the second six-way valve 400 is communicated with the 4# interface of the first six-way valve 300, the 6# interface of the second six-way valve 400 is communicated with the 5# interface of the second six-way valve 400, the 4# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, the 3# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, the 1# interface of the second six-way valve 400 is communicated with the 2# interface of the second six-way valve 400, the 1# interface of the second six-way valve 400 is connected with the outlet end of the first enrichment column 500, the 2# interface of the second six-way valve 400 is connected with a detection device, and the 3# interface of the second six-way valve 400 is connected with the inlet end of the second enrichment column 800; the 1# interface of the third six-way valve 700 is connected with the inlet end of the first enrichment column 500, the 2# interface of the third six-way valve 700 is communicated with the 1# interface of the third six-way valve 700, the 2# interface of the third six-way valve 700 is connected with the second pump body 200, the 3# interface of the third six-way valve 700 is connected with the outlet end of the second enrichment column 800, the 4# interface of the third six-way valve 700 is communicated with the 3# interface of the third six-way valve 700, the 6# interface of the third six-way valve 700 is communicated with the 4# interface of the third six-way valve 700, the 5# interface of the third six-way valve 700 is communicated with the 6# interface of the third six-way valve 700, and the 5# interface of the third six-way valve 700 is connected with waste liquid. The second pump body 200 delivers an eluent to elute the first enrichment column 500 for on-line measurement while the second sample is injected into the dosing ring 600. The first pump body 100 delivers the mobile phase to flush the dosing ring 600, enriching the second sample to the second enrichment column 800.

Referring to fig. 12, when the first six-way valve 300 is located at the second position, the second six-way valve 400 is located at the fourth position, and the third six-way valve 700 is located at the sixth position; the 5# interface of the second six-way valve 400 is communicated with the 4# interface of the first six-way valve 300, the 4# interface of the second six-way valve 400 is communicated with the 5# interface of the second six-way valve 400, the 6# interface of the second six-way valve 400 is communicated with the 4# interface of the second six-way valve 400, the 1# interface of the second six-way valve 400 is communicated with the 6# interface of the second six-way valve 400, the 2# interface of the second six-way valve 400 is communicated with the 3# interface of the second six-way valve 400, the 1# interface of the second six-way valve 400 is connected with the inlet end of the first enrichment column 500, the 2# interface of the second six-way valve 400 is connected with a detection device, and the 3# interface of the second six-way valve 400 is connected with the outlet end of the second enrichment column 800; the 1# interface of the third six-way valve 700 is connected with the outlet end of the first enrichment column 500, the 6# interface of the third six-way valve 700 is communicated with the 1# interface of the third six-way valve 700, the 4# interface of the third six-way valve 700 is communicated with the 6# interface of the third six-way valve 700, the 5# interface of the third six-way valve 700 is communicated with the 4# interface of the third six-way valve 700, the 2# interface of the third six-way valve 700 is connected with the second pump body 200, the 3# interface of the third six-way valve 700 is connected with the inlet end of the second enrichment column 800, and the 5# interface of the third six-way valve 700 is connected with waste liquid. The second pump body 200 delivers the eluent to elute the second enrichment column 800 for on-line measurement while the first pump body 100 delivers the mobile phase to flush the dosing ring 600 to enrich the first sample to the first enrichment column 500. The embodiment of the utility model also provides an application method of the online enrichment treatment system, which is based on any one of the online enrichment treatment systems and comprises the following steps:

The first sample is fed to the dosing ring 600;

activating the first pump body 100 to deliver the mobile phase to flush the dosing ring 600 to enrich the first sample to the first enrichment column 500;

starting the second pump body 200 to deliver eluent to elute the first enrichment column 500, realizing online measurement, and simultaneously, injecting a second sample into the quantitative loop 600;

activating the first pump body 100 to deliver the mobile phase to flush the dosing ring 600 to enrich the second sample to the second enrichment column 800;

starting the second pump body 200 to deliver eluent to elute the second enrichment column 800, so as to realize online measurement, and simultaneously, introducing a first sample into the quantitative loop 600;

the above steps are cycled.

The embodiment can realize accurate sample injection through the quantitative ring, is also suitable for samples with the sample quantity smaller than 15ml, and can realize on-line enrichment of two samples by arranging three six-way valves to realize the switching between the states of the six-way valves.

Referring to FIG. 13, in some embodiments of the present utility model, the on-line enrichment processing system further includes a programmable logic controller 11, and the status and position switching of the various components in the on-line enrichment processing system are automatically controlled by the programmable logic controller 11.

The first pump body 100, the second pump body 200, the first six-way valve 300, the second six-way valve 400 and the third six-way valve 700 are respectively electrically connected with the programmable logic controller 11, the programmable logic controller 11 can control the start and stop of the first pump body 100 and the second pump body 200, and can control the switching of the first six-way valve 300 between the first position and the second position, the switching of the second six-way valve 400 between the third position and the fourth position, the switching of the third six-way valve 700 between the fifth position and the sixth position, and under a preset program, a plurality of different control programs can be combined to meet the detection requirement of the on-line enrichment processing system.

Referring to fig. 14, in particular, in some embodiments of the present utility model, the programmable logic controller 11 includes a power module 111, a central processor 112, a storage module 113, an input module 114, an output module 115, and a peripheral interface module 116; the power module 111, the storage module 113, the input module 114, the output module 115, and the peripheral interface module 116 are electrically connected to the central processor 112, respectively, and the first pump body 100, the second pump body 200, the first six-way valve 300, the second six-way valve 400, and the third six-way valve 700 are electrically connected to the output module 115, respectively.

The peripheral interface module 116 may be connected to a computer, etc. to write the online enrichment process program into the programmable logic controller 11, and store the online enrichment process program written into the programmable logic controller 11 in the storage module 113, and when the peripheral interface module is started, the central processor 112 invokes the online enrichment process program, and outputs a signal from the output module 115 to drive the first pump body 100, the second pump body 200, the first six-way valve 300, the second six-way valve 400, and the third six-way valve 700 to operate.

In some embodiments of the utility model, the output module 115 may be a pulse output unit. That is, the programmable logic controller 11 may drive the first pump body 100, the second pump body 200, the first six-way valve 300, the second six-way valve 400, and the third six-way valve 700 to operate using the pulse signal.

In some embodiments of the present utility model, the output module 115 may also be a digital output unit. That is, the programmable logic controller 11 may drive the first pump body 100, the second pump body 200, the first six-way valve 300, the second six-way valve 400, and the third six-way valve 700 to operate using digital signals.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present utility model, and are not limiting; although the utility model has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present utility model.

Claims

1. The on-line enrichment treatment system is characterized by comprising two pump bodies, a first six-way valve, a second six-way valve, a third six-way valve, a first enrichment column and a second enrichment column;

2. The on-line enrichment processing system according to claim 1, wherein a dosing ring is provided between the two interfaces of the first six-way valve;

When the first six-way valve is switched to a first state, the second six-way valve is correspondingly positioned at a first position, and when the third six-way valve is correspondingly positioned at a third position, a pump body which is in fluid communication with the third six-way valve conveys eluent to elute the first enrichment column so as to perform online measurement, and meanwhile, a second sample is injected into a quantitative ring;

3. The on-line enrichment processing system according to claim 2, wherein the 1# interface of the first six-way valve is connected with a sample injection device, and the 2# interface is connected with a waste liquid;

4. The on-line enrichment processing system according to claim 2, wherein the No. 5 interface of the two-six-way valve is in communication with the first six-way valve, and the No. 2 interface is connected with a detection device;

5. The on-line enrichment processing system according to claim 2, wherein the port 2 of the third six-way valve is in communication with one of the pump bodies, and the port 5 is in communication with the waste liquid;