CN219400209U - Small-sized micro-fluid chip - Google Patents
Small-sized micro-fluid chip Download PDFInfo
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- CN219400209U CN219400209U CN202320280190.1U CN202320280190U CN219400209U CN 219400209 U CN219400209 U CN 219400209U CN 202320280190 U CN202320280190 U CN 202320280190U CN 219400209 U CN219400209 U CN 219400209U
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The utility model relates to the technical field of microfluidic chips, in particular to a small microfluidic chip, which comprises a chip main body and a heat sealing film, wherein a micro-channel is formed in the front side of the chip main body, a liquid separation channel is arranged at the lower end of the micro-channel, a reaction tank is arranged at the lower end of the liquid separation channel, a sample injection channel is arranged at one end of the micro-channel, a sample injection port is arranged at the outer end of the sample injection channel, a connecting channel is arranged at the other end of the micro-channel, a sample outlet is arranged at one end of the micro-channel, a sample outlet sealing plug is arranged at the position, corresponding to the sample injection port, of the rear side of the chip main body. The utility model adopts a centrifugal mode to guide the sample in the micro-channel into the reaction tank, the reaction tank is injection molded by a die, the volume of fluid entering the reaction tank is accurately controlled, and the quantity and the distribution positions of the reaction tank can be designed according to different micro-fluid chips.
Description
Technical Field
The utility model relates to the technical field of microfluidic chips, in particular to a small microfluidic chip.
Background
Microfluidic chips, also known as "lab-on-a-chip", are a multi-disciplinary crossover technique that has emerged in the late twentieth century, and are generally composed of reaction tanks and interconnected microchannels, and by precisely controlling the flow of liquid, the maximum utilization efficiency of reagent consumables is achieved, and the functions of the whole laboratory, including reaction, detection, etc., are integrated on the chip.
The utility model discloses a microfluidic chip, (issued publication number CN 212284074U), which is provided with a heat insulation groove structure, and can realize rapid temperature rise and fall, so that the PCR reaction time is greatly shortened, the microfluidic chip can realize high-precision integration, especially chipification, through a silicon-based microfluidic chip technology, thereby realizing portability and miniaturization of equipment, and large-scale mass production, and being beneficial to reducing equipment cost. Accordingly, one skilled in the art would provide a compact microfluidic chip to address the problems set forth in the background above.
Disclosure of Invention
The present utility model is directed to a small microfluidic chip for solving the above-mentioned problems.
In order to achieve the above purpose, the present utility model provides the following technical solutions:
the utility model provides a small-size microfluid chip, includes chip main part and heat-seal membrane, the heat-seal membrane is located the front side position department of chip main part, the microchannel has been seted up to the front side of chip main part, the lower extreme of microchannel is provided with the branch liquid passageway, the lower extreme of dividing the liquid passageway is provided with the reaction tank, the one end of microchannel is provided with the introduction channel, the outer end of introduction channel is provided with the inlet, the other end of microchannel is provided with connecting channel, the one end of microchannel is provided with out the appearance passageway, the outer end of going out the appearance passageway is provided with out the appearance mouth.
As still further aspects of the utility model: the position department that the rear side of chip main part corresponds the sample inlet is provided with the sample inlet sealing plug, the position department that the rear side of chip main part corresponds the sample outlet passageway is provided with the sample outlet sealing plug, the fluid valve is all installed to the both ends position department of micro channel.
As still further aspects of the utility model: the output end of the sample inlet is communicated with the input end of the sample inlet channel, the output end of the sample inlet channel is communicated with the input end of the micro-channel, the lower end of the micro-channel is communicated with the upper end of the liquid separation channel, the lower end of the liquid separation channel is communicated with the reaction tank, the output end of the micro-channel is communicated with the input end of the sample outlet channel, and the output end of the sample outlet channel is communicated with the input end of the sample outlet.
As still further aspects of the utility model: four groups of micro-channels, liquid separation channels and reaction tanks are arranged, seven micro-channels, liquid separation channels and reaction tanks are arranged in each group, and two groups of micro-channels are communicated through connecting channels.
As still further aspects of the utility model: the volume of the micro flow channel is 1.2mm 3 The volume of the reaction tank is 1mm 3 。
As still further aspects of the utility model: the micro-flow channel is communicated through the fluid valve, the sample inlet sealing plug is clamped at the inner position of the sample inlet, and the sample outlet sealing plug is clamped at the inner position of the sample outlet channel.
Compared with the prior art, the utility model has the beneficial effects that: the small microfluidic chip of the utility model guides the sample in the microfluidic channel into the reaction tank in a centrifugal way, the reaction tank is injection molded by a die, the volume and the size are accurate, the volume of fluid entering the reaction tank is accurately controlled, the number and the distribution positions of the reaction tank can be designed according to different microfluidic chips, and the microfluidic channel of the microfluidic chip can be designed into S-shaped and U-shaped chips with various shapes.
Drawings
FIG. 1 is a schematic diagram of a small microfluidic chip;
FIG. 2 is a rear view of a miniature microfluidic chip;
FIG. 3 is a schematic diagram of the structure of a chip body in a small microfluidic chip;
fig. 4 is a schematic structural diagram of a portion a of fig. 3 of a small microfluidic chip.
In the figure: 1. a chip main body; 2. a heat sealing film; 3. a microchannel; 4. a reaction tank; 5. a connection channel; 6. a sample introduction channel; 7. a sample inlet; 8. a sample outlet channel; 9. a sample outlet; 10. a fluid valve; 11. a liquid separation channel; 12. a sample inlet sealing plug; 13. and sealing plug of sample outlet.
Detailed Description
Referring to fig. 1 to 4, in an embodiment of the present utility model, a small microfluidic chip includes a chip main body 1 and a heat sealing film 2, the heat sealing film 2 is located at a front side position of the chip main body 1, a micro-channel 3 is provided at a front side of the chip main body 1, a liquid separation channel 11 is provided at a lower end of the micro-channel 3, a reaction tank 4 is provided at a lower end of the liquid separation channel 11, a sample introduction channel 6 is provided at one end of the micro-channel 3, a sample introduction port 7 is provided at an outer end of the sample introduction channel 6, a connecting channel 5 is provided at the other end of the micro-channel 3, a sample discharge channel 8 is provided at one end of the micro-channel 3, a sample discharge port 9 is provided at an outer end of the sample discharge channel 8, an output end of the sample introduction port 7 is communicated with an input end of the sample introduction channel 6, an output end of the sample introduction channel 6 is communicated with an input end of the micro-channel 3, a lower end of the micro-channel 3 is communicated with an upper end of the liquid separation channel 11, a lower end of the liquid separation channel 11 is communicated with a reaction tank 4, an output end of the micro-channel 3 is communicated with a sample discharge portThe input end of the channel 8 is communicated, the output end of the sample outlet channel 8 is communicated with the input end of the sample outlet 9, four groups of micro-channels 3, liquid separation channels 11 and reaction tanks 4 are arranged, seven groups of micro-channels 3, liquid separation channels 11 and reaction tanks 4 are arranged, two groups of micro-channels 3 are communicated through the connecting channel 5, and the volume of the micro-channels 3 is 1.2mm 3 The volume of the reaction tank 4 was 1mm 3 Firstly, taking out a small microfluidic chip, then adding a sample into the micro-channels 3 through the sample inlet 7 and the sample inlet channel 6, circulating the samples in the two adjacent micro-channels 3 through the connecting channel 5, stopping the liquid adding operation when the sample overflows from the sample outlet 9, plugging the sample inlet sealing plug 12 into the sample inlet 7, plugging the sample outlet sealing plug 13 into the sample outlet channel 8, placing the small microfluidic chip filled with the sample into a centrifuge, and rotating clockwise at a rotating speed of about 7000 rpm for 60 seconds, wherein the samples in the micro-channels 3 enter the reaction tank 4 through the liquid separating channel 11.
In fig. 2, 3, 4: the back side of the chip main body 1 is provided with a sample inlet sealing plug 12 corresponding to the position of the sample inlet 7, the back side of the chip main body 1 is provided with a sample outlet sealing plug 13 corresponding to the position of the sample outlet channel 8, the two ends of the micro-channel 3 are provided with fluid valves 10, the micro-channel 3 is communicated through the fluid valves 10, the sample outlet sealing plug 12 is clamped at the inner position of the sample inlet 7, the sample outlet sealing plug 13 is clamped at the inner position of the sample outlet channel 8, the small micro-fluid chip is taken out, the sample inlet sealing plug 12 in the sample inlet 7 is taken out, the sample is taken out from the sample outlet sealing plug 13 in the sample outlet channel 8, then, the sample is added into the micro-channel 3 through the sample inlet 7 and the sample inlet channel 6, the samples in two adjacent micro-channels 3 circulate through the fluid valves 10, and the samples in the adjacent two rows of micro-channels 3 circulate through the connecting channel 5.
The working principle of the utility model is as follows: firstly, taking out a small microfluidic chip, taking out a sample inlet sealing plug 12 in the sample inlet 7, taking out a sample outlet sealing plug 13 in the sample outlet channel 8, then adding a sample into the micro-channel 3 through the sample inlet 7 and the sample inlet channel 6, circulating the samples in the two adjacent micro-channels 3 through a fluid valve 10, circulating the samples in the micro-channels 3 adjacent to each other through a connecting channel 5, stopping the liquid adding operation when the sample outlet 9 overflows the samples, plugging the sample inlet sealing plug 12 into the sample inlet 7, plugging the sample outlet sealing plug 13 into the sample outlet channel 8, putting the small microfluidic chip filled with the samples into a centrifuge, and rotating clockwise for about 7000 revolutions per minute for 60 seconds, wherein the samples in the micro-channels 3 enter the reaction tank 4 through the liquid separating channel 11.
The foregoing description is only a preferred embodiment of the present utility model, but the scope of the present utility model is not limited thereto, and any person skilled in the art, who is within the scope of the present utility model, should make equivalent substitutions or modifications according to the technical solution of the present utility model and the inventive concept thereof, and should be covered by the scope of the present utility model.
Claims (6)
1. The utility model provides a small-size micro-fluidic chip, includes chip main part (1) and heat-seal membrane (2), heat-seal membrane (2) are located the front side position department of chip main part (1), a serial communication port, micro-channel (3) have been seted up to the front side of chip main part (1), the lower extreme of micro-channel (3) is provided with branch liquid passageway (11), the lower extreme of branch liquid passageway (11) is provided with reaction tank (4), the one end of micro-channel (3) is provided with sampling channel (6), the outer end of sampling channel (6) is provided with inlet (7), the other end of micro-channel (3) is provided with connecting channel (5), the one end of micro-channel (3) is provided with out appearance passageway (8), the outer end of going out appearance passageway (8) is provided with out appearance mouth (9).
2. The miniature microfluidic chip according to claim 1, wherein a sample inlet sealing plug (12) is arranged at a position of the rear side of the chip main body (1) corresponding to the sample inlet (7), a sample outlet sealing plug (13) is arranged at a position of the rear side of the chip main body (1) corresponding to the sample outlet channel (8), and fluid valves (10) are arranged at two end positions of the micro flow channel (3).
3. The small-sized micro fluidic chip according to claim 1, wherein the output end of the sample inlet (7) is communicated with the input end of the sample inlet channel (6), the output end of the sample inlet channel (6) is communicated with the input end of the micro flow channel (3), the lower end of the micro flow channel (3) is communicated with the upper end of the liquid separation channel (11), the lower end of the liquid separation channel (11) is communicated with the reaction tank (4), the output end of the micro flow channel (3) is communicated with the input end of the sample outlet channel (8), and the output end of the sample outlet channel (8) is communicated with the input end of the sample outlet (9).
4. The miniature microfluidic chip according to claim 1, wherein four groups of the micro flow channels (3), the liquid separation channels (11) and the reaction tank (4) are arranged, seven groups of the micro flow channels (3), the liquid separation channels (11) and the reaction tank (4) are arranged, and two groups of the micro flow channels (3) are communicated through the connecting channel (5).
5. A miniaturized microfluidic chip according to claim 1, wherein the volume of the microchannel (3) is 1.2mm 3 The volume of the reaction tank (4) is 1mm 3 。
6. A small microfluidic chip according to claim 2, characterized in that the micro flow channels (3) are communicated with each other by means of fluid valves (10), the sample inlet sealing plugs (12) are clamped at the inner positions of the sample inlet (7), and the sample outlet sealing plugs (13) are clamped at the inner positions of the sample outlet channels (8).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320280190.1U CN219400209U (en) | 2023-02-22 | 2023-02-22 | Small-sized micro-fluid chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320280190.1U CN219400209U (en) | 2023-02-22 | 2023-02-22 | Small-sized micro-fluid chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219400209U true CN219400209U (en) | 2023-07-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320280190.1U Active CN219400209U (en) | 2023-02-22 | 2023-02-22 | Small-sized micro-fluid chip |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219400209U (en) |
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2023
- 2023-02-22 CN CN202320280190.1U patent/CN219400209U/en active Active
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