CN219224816U

CN219224816U - Reagent tube sample-adding pre-processing assembly

Info

Publication number: CN219224816U
Application number: CN202221772065.4U
Authority: CN
Inventors: 贾秀伟; 章月凯; 莫亚聪; 蔡宁
Original assignee: Tuling Hangzhou Biomedical Co ltd
Current assignee: Tuling Hangzhou Biomedical Co ltd
Priority date: 2022-07-11
Filing date: 2022-07-11
Publication date: 2023-06-20
Anticipated expiration: 2032-07-11

Abstract

The utility model discloses a reagent tube sample adding pre-processing component, which aims to overcome the defects of an automatic slide processing instrument in the prior art in the aspect of automatic treatment of reagent tubes, can automatically process reagent tubes sealed by a rotary cover, and automatically complete mixing, uncovering and covering of the reagent tubes so as to facilitate sampling processing of a subsequent sample adding needle device, thereby being capable of allowing the reagent storage quantity of the reagent tubes to be improved and being more suitable for long-time multi-batch automatic experimental treatment. The component comprises a mechanical grabbing arm, a reagent tube storage module, a mixing module and a cover opening module; the reagent tube storage module is internally provided with a reagent tube, the mechanical gripper arm is suspended above the reagent tube storage module, and the cover opening module comprises a rotating mechanism and a clamping mechanism arranged above the rotating mechanism and used for clamping the reagent tube.

Description

Reagent tube sample-adding pre-processing assembly

Technical Field

The utility model relates to the field of experimental instruments, in particular to an automatic device assembly capable of pre-processing sample addition of a reagent tube.

Background

In the process of slide sample treatment and other similar experimental operations, corresponding reagents are required to be added to sample slides for reaction experiments, and the slide sample adding treatment instrument adopts an automatic instrument to replace manual work to complete complicated sample adding operation. In the prior art, the instrument and the equipment are used for processing an automatic sample adding link, a special reagent tube is adopted, a cover which is easy to puncture is arranged on a reagent bottle, and a sampling needle is directly inserted through the cover for sampling. In the technical scheme, the sealing cover on the reagent tube cannot be reused, so that great waste is caused. Moreover, since the sealability of the pierced cap is lowered, the sample-adding reagent in the reagent tube cannot be stored for a long time, and only the amount of one sampling by the sampling needle is usually stored, so that a large number of reagent tubes need to be arranged to perform a long-time multi-sampling sample-adding work. Therefore, in view of practical application demands, if an automation device for carrying out cover opening treatment before sample loading by adopting a reagent tube sealed by a rotary cover can be designed, the automation degree of a slide treatment instrument can be greatly improved.

Disclosure of Invention

The utility model aims to overcome the defects of an automatic slide processing instrument in the prior art in the aspect of automatic treatment of reagent tubes, and provides a reagent tube sample adding pre-processing assembly which can automatically process reagent tubes sealed by a screw cap, and automatically complete mixing, uncovering and covering of the reagent tubes so as to facilitate sampling processing of a subsequent sample adding needle device, thereby allowing the reagent storage quantity of the reagent tubes to be improved and being more suitable for long-time multi-batch automatic experimental processing.

In order to achieve the above purpose, the present utility model adopts the following technical scheme:

the utility model relates to a reagent tube sample adding pre-processing assembly which comprises a mechanical grabbing arm, a reagent tube storage module, a mixing module and a cover opening module; the reagent tube storage module is internally provided with a reagent tube, the mechanical gripper arm is suspended above the reagent tube storage module, and the cover opening module comprises a rotating mechanism and a clamping mechanism arranged above the rotating mechanism and used for clamping the reagent tube.

Preferably, the cover opening module comprises a rotating mechanism and a clamping mechanism arranged above the rotating mechanism, the rotating mechanism comprises a first control motor and a rotating bracket driven by the first control motor, the clamping mechanism comprises a pair of clamping blocks, a control screw rod and a second control motor which are arranged on the rotating bracket, a guide block is arranged at the top of the rotating bracket, the middle parts of the clamping blocks are slidably connected with the guide block, a nut is arranged at the lower end of the clamping blocks, the nut is sleeved with the control screw rod, and the second control motor drives the control screw rod.

Preferably, the reagent tube storage module comprises at least one single-row reagent tube rack and a long strip-shaped slide way, the single-row reagent tube rack is in sliding connection with the slide way, and the mixing module and the cover opening module are arranged at one end of the base.

Preferably, the bottom of the single-row reagent pipe rack is provided with a chute extending along the passing direction of the single-row reagent pipe rack, the bottom of the inner side of the chute is provided with a strip-shaped protrusion matched with the chute, the single-row reagent pipe rack is arranged in the chute in parallel, and the chute is connected with the protrusion in a sliding way.

Preferably, the mechanical gripper arm comprises a three-coordinate driving device and a mechanical finger mechanism, wherein the three-coordinate driving device comprises a first translation module, a second translation module and a lifting module which are sequentially connected, the mechanical finger mechanism is arranged on the lifting module, and the direction of the first translation module is parallel to the through length direction of the single-row reagent tube rack.

Preferably, the first translation module, the second translation module and the lifting module all adopt synchronous belt linear driving modules.

Preferably, the mixing module comprises a motor support, a third driving motor, an eccentric wheel and an eccentric rotating seat, wherein the third driving motor is vertically arranged on the motor support, and the third driving motor, the eccentric wheel and the eccentric rotating seat are sequentially connected.

Preferably, the reagent tube top is equipped with the two-dimensional code, and the robotic arm is equipped with and is used for scanning the camera of two-dimensional code.

Therefore, the utility model has the following beneficial effects: (1) The reagent tube sealed by the spiral cover can be automatically processed, and the reagent tube is automatically mixed, uncapped and closed, so that the subsequent sample adding needle device can sample, the sealing effect of the reagent tube sealed by the spiral cover is better, the reagent storage amount is more, and the long-time multi-batch experiment is facilitated; (2) The scheme comprises a step of uniformly mixing the reagent tubes, and adopts a vibration uniform mixing scheme to ensure that the sample adding reagent is not layered to influence the use due to long-time placement before uncapping and sampling each time; (3) The reagent tube storage module realizes batch quick replacement of reagent tubes, and is favorable for linking preparation work among multiple batches of experiments.

Drawings

FIG. 1 is a top view block diagram of a reagent tube loading pre-processing assembly of the present application.

Fig. 2 is a diagram showing an example of application of the reagent tube loading pre-processing assembly of the present application to a slide automated processing apparatus.

Fig. 3 is a top view of the reagent tube loading pre-processing assembly of the present application with the single row of reagent tube racks replaced.

FIG. 4 is a cross-sectional view of a single row of reagent tube racks in a reagent tube loading pre-processing assembly of the present application.

Fig. 5 is a schematic structural view of the door module in the present application.

Fig. 6 is a schematic structural diagram of a blending module in the present application.

Fig. 7 is a schematic structural view of the mechanical arm in the present application.

In the figure: 1. a mechanical gripper arm; 101. a first translation module; 102. a second translation module; 103. a lifting module; 104. a mechanical finger mechanism; 201. a single row of reagent tube racks; 202. a chute; 203. a slideway; 204. a protrusion; 3. a reagent tube; 301. screwing the cover; 4. a cover opening module; 401. a first control motor; 402. a rotating bracket; 403. a clamping block; 404. a control screw rod; 405. a second control motor; 406. a guide block; 5. a mixing module; 501. a motor bracket; 502. a third driving motor; 503. an eccentric wheel; 504. an eccentric rotating seat.

Detailed Description

The utility model is further described below with reference to the drawings and detailed description.

As shown in fig. 1 and 2, the reagent tube 3 sample adding pre-processing assembly comprises a mechanical grabbing arm 1, a reagent tube storage module, a mixing module 5 and a cover opening module 4; the reagent tube 3 is stored in the reagent tube 3 storage module, the mechanical grabbing arm 1 is suspended above the reagent tube 3 storage module, and the cover opening module 4 comprises a rotating mechanism and a clamping mechanism arranged above the rotating mechanism and used for clamping the reagent tube 3. For convenience of description, fig. 2 is a schematic structural diagram of the reagent tube 3 sample-adding pre-processing assembly applied to the automatic slide processing apparatus according to the present embodiment, where the reagent tube 3 storage module, the mixing module 5, and the uncapping module 4 may be disposed at the bottom of the chassis, and the mechanical gripper arm 1 is disposed at the top of the chassis.

As shown in fig. 1, 3 and 4, the reagent tube storage module includes at least one single-row reagent tube 3 frame 201 and a long-strip-shaped slide 203, the single-row reagent tube 3 frame 201 and the slide 203 are slidably connected, and the mixing module 5 and the cover opening module 4 are disposed at one end of the base. The bottom of the single-row reagent tube 3 frame 201 is provided with a chute 202 extending along the passing direction of the single-row reagent tube 3 frame, the bottom of the inner side of the chute 203 is provided with a strip-shaped protrusion 204 matched with the chute 202, the single-row reagent tube 3 frame 201 is arranged in the chute 203 in parallel and in parallel, and the chute 202 is in sliding connection with the protrusion 204.

The reagent tube 3 top is equipped with the two-dimensional code, and mechanical arm 1 is equipped with and is used for scanning the camera of two-dimensional code. The two-dimensional code is used for marking the identity of the reagent tube 3, and the mechanical arm 1 can identify the type of the reagent in the reagent tube 3 through the control system by scanning and identifying through the camera, so that the requirement of automatic processing is met.

As shown in fig. 5, the cover opening module 4 includes a rotating mechanism and a clamping mechanism disposed above the rotating mechanism, the rotating mechanism includes a first control motor 401 and a rotating bracket 402 driven by the first control motor 401, the clamping mechanism includes a pair of clamping blocks 403 disposed on the rotating bracket 402, a control screw 404 and a second control motor 405, a guide block 406 is disposed on the top of the rotating bracket 402, the middle portions of the pair of clamping blocks 403 are slidably connected with the guide block 406, a nut is disposed at the lower end of the clamping blocks 403, the nut is sleeved with the control screw 404, and the second control motor 405 drives the control screw 404.

In the uncapping process, the clamping mechanism is used for clamping the body part of the reagent tube 3, the mechanical gripper arm 1 is used for grabbing the rotary cover 301 part, the mechanical gripper arm 1 is controlled to rotate through the rotary support 402, the mechanical gripper arm 1 is lifted synchronously, and the rotary cover 301 can be opened easily, so that reagents can be extracted from a subsequent sample adding needle.

As shown in fig. 6, the mixing module 5 includes a motor bracket 501, a third driving motor 502, an eccentric wheel 503, and an eccentric rotating seat 504, where the third driving motor 502 is vertically disposed on the motor bracket 501, and the third driving motor 502, the eccentric wheel 503, and the eccentric rotating seat 504 are sequentially connected.

The third driving motor 502 drives the eccentric wheel 503 and the eccentric rotating seat 504 to rotate, and the effect of shaking and evenly mixing the reagent is realized under the eccentric action. Before each uncapping sampling, the mechanical gripper arm 1 places the bottom of the reagent tube 3 above the eccentric rotating seat 504, so as to ensure that the sample adding reagent can not be layered to influence the use due to long-time placement

As shown in fig. 7, the mechanical gripper arm 1 includes a three-coordinate driving device and a mechanical finger mechanism 104, where the three-coordinate driving device includes a first translation module 101, a second translation module 102 and a lifting module 103 connected in sequence, the mechanical finger mechanism 104 is disposed on the lifting module 103, and the direction of the first translation module 101 is parallel to the through length direction of the single-row reagent tube 3 rack 201. The first translation module 101, the second translation module 102 and the lifting module 103 all adopt synchronous belt linear driving modules.

The layout mode of the reagent tube 3 storage module, the mixing module 5 and the cover opening module 4 can ensure that the working area of the mechanical arm 1 is concentrated and then the single row of reagent tube 3 frames 201 are communicated in the length direction, so that the translation distance requirement of the second translation module 102 is saved, the cost is reduced, and the control precision is improved.

Claims

1. The reagent tube sample adding pre-processing assembly is characterized by comprising a mechanical grabbing arm, a reagent tube storage module, a mixing module and a cover opening module; the reagent tube storage module is internally provided with a reagent tube, the reagent tube is provided with a spiral cover, the mechanical gripper arm is suspended above the reagent tube storage module, and the cover opening module comprises a rotating mechanism and a clamping mechanism arranged above the rotating mechanism and used for clamping the reagent tube.

2. The reagent tube sample loading pre-processing assembly according to claim 1, wherein the cover opening module comprises a rotating mechanism and a clamping mechanism arranged above the rotating mechanism, the rotating mechanism comprises a first control motor and a rotating bracket driven by the first control motor, the clamping mechanism comprises a pair of clamping blocks, a control screw rod and a second control motor which are arranged on the rotating bracket, a guide block is arranged at the top of the rotating bracket, the middle parts of the pair of clamping blocks are in sliding connection with the guide block, a nut is arranged at the lower end of the clamping block, the nut is sleeved with the control screw rod, and the second control motor drives the control screw rod.

3. The reagent tube sample application pre-processing assembly of claim 1, wherein the reagent tube storage module comprises at least one single-row reagent tube rack and an elongated slide, the single-row reagent tube rack is slidably connected to the slide, and the mixing module and the cover opening module are disposed at one end of the base.

4. The reagent tube sample-adding pre-processing assembly according to claim 3, wherein the bottom of the single-row reagent tube rack is provided with a chute extending along the direction of the passage of the single-row reagent tube rack, the bottom of the inner side of the chute is provided with a strip-shaped protrusion matched with the chute, the single-row reagent tube rack is arranged in the chute in parallel and in parallel, and the chute is connected with the protrusion in a sliding manner.

5. The reagent tube sample loading pre-processing assembly of claim 3, wherein the mechanical gripper arm comprises a three-coordinate driving device and a mechanical finger mechanism, the three-coordinate driving device comprises a first translation module, a second translation module and a lifting module which are sequentially connected, the mechanical finger mechanism is arranged on the lifting module, and the direction of the first translation module is parallel to the through length direction of the single-row reagent tube rack.

6. The reagent tube sample loading pre-processing assembly of claim 5, wherein the first translation module, the second translation module and the lifting module are all synchronous belt linear driving modules.

7. The reagent tube sample adding pre-processing assembly of claim 5, wherein the mixing module comprises a motor bracket, a third driving motor, an eccentric wheel and an eccentric rotating seat, the third driving motor is vertically arranged on the motor bracket, and the third driving motor, the eccentric wheel and the eccentric rotating seat are sequentially connected.

8. The reagent tube sample loading pre-processing assembly of claim 5, wherein the reagent tube top is provided with a two-dimensional code, and the mechanical gripper arm is provided with a camera for scanning the two-dimensional code.