CN219174491U - Nucleic acid purification column - Google Patents
Nucleic acid purification column Download PDFInfo
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- CN219174491U CN219174491U CN202223472510.8U CN202223472510U CN219174491U CN 219174491 U CN219174491 U CN 219174491U CN 202223472510 U CN202223472510 U CN 202223472510U CN 219174491 U CN219174491 U CN 219174491U
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
The utility model relates to the technical field and discloses a nucleic acid purification column which comprises a purification column body and a filter element, wherein the purification column body is provided with a liquid inlet and a liquid outlet which are oppositely arranged, the purification column body is provided with a filter cavity communicated with the liquid inlet and the liquid outlet, the position, close to the liquid outlet, of the filter cavity is provided with at least two bearing bulges, the two bearing bulges are arranged on the cavity wall of the filter cavity and protrude inwards, the upper surfaces of the bearing bulges are positioned on the same plane, and the filter element is arranged in the filter cavity and is propped against the bearing bulges. Based on the structure, the nucleic acid purification column replaces the column reinforcing ribs with the inward convex supporting bulges, the flow is smoother, and the nucleic acid purification column can still maintain higher filtration efficiency and has shorter liquid outlet time under the condition of higher liquid outlet speed when the centrifugal force is larger in the actual use process. In addition, the bearing bulge also plays a role of supporting and reinforcing ribs.
Description
Technical Field
The utility model relates to the technical field of biological detection, in particular to a nucleic acid purification column.
Background
In the field of biological detection, it is often necessary to filter and purify samples, especially in the field of molecular biology, it is often necessary to extract macromolecular substances such as DNA, RNA and the like from biological samples, and to separate and purify these macromolecular substances, so that efficient separation and purification of nucleic acid substances is a key technology in the field of molecular biology. Currently, in order to obtain a sufficient amount of nucleic acid sample, various nucleic acid isolation and enrichment methods such as phenol chloroform extraction, magnetic bead method, silica gel membrane method, etc. have been developed, and among them, the use of a silica gel membrane nucleic acid purification column is most widely used. The silica gel membrane nucleic acid purification column mainly uses a silica gel membrane as an adsorption column prepared by an adsorption material, when a nucleic acid sample passes through the silica gel membrane under the action of external force, the nucleic acid sample can be adsorbed by the silica gel membrane, then the nucleic acid is purified by washing with an organic solvent, and finally the nucleic acid sample is obtained by elution, so that the rapid separation and preparation of the nucleic acid sample are realized. The traditional silica gel membrane purifying column is of a circular tubular structure and comprises a circular tube column body, one end of the column body is provided with a sealing cover, the other end of the column body is filled with a porous sieve plate or a membrane, and materials capable of adsorbing biological substances such as nucleic acid are added on the porous sieve plate.
Chinese patent "nucleic acid purification column (patent number ZL 202021181674.3)" discloses a nucleic acid purification column which is provided with column reinforcing ribs with a net structure so as to improve the stability of the whole device, however, when the centrifugal force is large in the use process, the liquid outlet of the nucleic acid purification column can be blocked by the column reinforcing ribs, the filtration efficiency is low, and the liquid outlet time is long.
Disclosure of Invention
The utility model aims to provide a nucleic acid purification column with high filtration efficiency.
In order to achieve the above object, the present utility model provides a nucleic acid purification cartridge comprising:
the purification column comprises a purification column body, a liquid inlet and a liquid outlet, wherein the liquid inlet and the liquid outlet are oppositely arranged, and a filter cavity which is communicated with the liquid inlet and the liquid outlet is formed in the purification column body;
at least two bearing bulges are arranged at the position, close to the liquid outlet, of the filter cavity, the two bearing bulges are arranged on the cavity wall of the filter cavity and protrude inwards, and the upper surfaces of the bearing bulges are positioned on the same plane;
the filter piece is arranged in the filter cavity and is propped against the supporting bulge.
In some embodiments of the present application, the number of the supporting protrusions is at least three, and the supporting protrusions are uniformly arranged along the circumference of the inner peripheral wall of the filter cavity.
In some embodiments of the present application, any two of the bearing protrusions do not contact.
In some embodiments of the present application, the bearing protrusion is divided into a first protrusion and a second protrusion, the first protrusion and the second protrusion are all set to be a plurality of, a plurality of the first protrusions and a plurality of the second protrusions are alternately arranged, note that the first protrusion protrudes from the length of the filter cavity wall along the axial direction of the purification column body is M, note that the second protrusion protrudes from the length of the filter cavity wall along the axial direction of the purification column body is N, M > N.
In some embodiments of the present application, the area of the liquid inlet is larger than the area of the liquid outlet;
the filter cavity comprises a first cavity section and a second cavity section which are sequentially arranged, the first cavity section is communicated with the liquid inlet, the cross-sectional area of the first cavity section is unchanged, the second cavity section is communicated with the liquid outlet, and the cross-sectional area of the second cavity section is gradually reduced along the sample outlet direction.
In some embodiments of the present application, the bearing projection is disposed at the second cavity section.
In some embodiments of the present application, the filter cartridge further comprises a pressure ring disposed within the filter chamber and on a side of the filter facing away from the support protrusion, the pressure ring configured to limit further movement of the filter toward the liquid inlet.
In some embodiments of the present application, the outer peripheral wall of the pressure ring is provided with a plurality of abutting protrusions, the abutting protrusions are uniformly distributed along the outer peripheral wall of the pressure ring, a notch is formed between any two adjacent abutting protrusions, and the pressure ring is in interference fit with the cavity wall of the filter cavity through the abutting protrusions.
In some embodiments of the present application, further comprising a waste tube formed with a waste port into which the purification cartridge body can be inserted;
the periphery wall distribution of purification post body is provided with two at least ribs, the rib is followed purification post body radially outwards outstanding, purification post body passes through the rib with the inner wall interference fit of waste liquid pipe, the periphery wall of purification post body except the rib the position with be formed with the clearance between the inner wall of waste liquid pipe.
In some embodiments of the present application, the purification column is further provided with an end cap, which is connected to an edge of the liquid inlet in a reversible manner through a connection portion, and the end cap is used for opening and closing the liquid inlet.
The utility model provides a nucleic acid purification column, which has the beneficial effects that compared with the prior art:
the nucleic acid purification column comprises a purification column body and a filter element, wherein the purification column body is provided with a liquid inlet and a liquid outlet which are oppositely arranged, the purification column body is provided with a filter cavity which is communicated with the liquid inlet and the liquid outlet, at least two supporting bulges are arranged at positions, close to the liquid outlet, of the filter cavity, the two supporting bulges are arranged on the cavity wall of the filter cavity and protrude inwards, the upper surfaces of the supporting bulges are positioned on the same plane, and the filter element is arranged in the filter cavity and is propped against the supporting bulges. Based on the structure, the column body reinforcing rib of the reticular structure is replaced by the inward convex supporting bulge, waste liquid filtered by the filter disc is not blocked by the reticular structure, the flow is smoother, and the nucleic acid purification column can still maintain higher filtering efficiency and shorter liquid outlet time under the condition of higher liquid outlet speed when the centrifugal force is larger in the actual use process. In addition, the supporting bulge also plays a role of supporting and reinforcing ribs, so that the stability of the purification column body can be improved, and the purification column body cannot be deformed or broken even if the purification column body is subjected to strong acting force.
Drawings
FIG. 1 is a schematic diagram showing the split structure of a nucleic acid purification cartridge according to an embodiment of the present utility model;
FIG. 2 is a schematic diagram of a purification column body according to an embodiment of the present utility model;
FIG. 3 is a schematic diagram of a purification column body according to an embodiment of the present utility model;
FIG. 4 is a schematic top view of a purification column body according to an embodiment of the present utility model;
FIG. 5 is a schematic cross-sectional view of a nucleic acid purification cartridge according to an embodiment of the present utility model;
FIG. 6 is a partial schematic view of the area A in FIG. 5;
FIG. 7 is a partial schematic view of region B of FIG. 5;
fig. 8 is a schematic structural view of a pressure ring according to an embodiment of the present utility model.
In the figure: 1. purifying the column body; 11. a liquid inlet; 12. a liquid outlet; 13. a filter chamber; 131. a first chamber section; 132. a second chamber section; 14. a rib; 2. a supporting bulge; 21. a first boss; 22. a second protruding portion; 3. a filter; 4. a compression ring; 41. the abutting bulge; 42. a notch portion; 5. a waste liquid pipe; 51. a waste liquid port; 6. an end cap; 61. and a connecting part.
Detailed Description
The following description of the embodiments of the present application will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all, of the embodiments of the present application.
It should be understood that in the description of the present application, the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships based on the orientations or positional relationships illustrated in the drawings, merely to facilitate description of the present application and simplify the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present application. The terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated, i.e., features defining "first," "second," may explicitly or implicitly include one or more such features. Furthermore, unless otherwise indicated, the meaning of "a plurality" is two or more.
It should be noted that, in the description of the present application, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art in a specific context.
As shown in fig. 1 to 4, the embodiment of the present utility model provides a nucleic acid purification cartridge, which comprises a cartridge body 1 and a filter 3, wherein the cartridge body 1 is formed with a liquid inlet 11 and a liquid outlet 12 which are disposed opposite to each other, and the cartridge body 1 is formed with a filter chamber 13 communicating the liquid inlet 11 and the liquid outlet 12, that is, the cartridge body 1 is hollow.
FIG. 5 is a sectional view taken along a vertical plane passing through the axial center of the filter chamber 13 when the nucleic acid purification cartridge is arranged vertically. Referring to fig. 4, 5 and 6, at least two supporting protrusions 2 are disposed at positions of the filter cavity 13 near the liquid outlet 12, the two supporting protrusions 2 are disposed on the cavity wall of the filter cavity 13 and protrude inwards, and the upper surfaces of the supporting protrusions are located on the same plane.
The filter element 3 is arranged in the filter cavity 13 and is abutted against the supporting bulge 2. Specifically, the filter 3 may be in the form of a filter, or may be in other forms such as a filter membrane, and may be selected from a silica gel membrane, a glass fiber membrane, a silica nanomaterial filter, a graphene filter, and the like, depending on the actual application.
Based on the structure, the column reinforcing rib of the reticular structure is replaced by the inward convex supporting bulge 2, waste liquid filtered by the filter disc is not blocked by the reticular structure, the flow is smoother, and the nucleic acid purification column can still maintain higher filtering efficiency and shorter liquid outlet time under the condition of higher liquid outlet speed when the centrifugal force is larger in the actual use process. In addition, the supporting protrusions 2 also play a role of supporting and reinforcing ribs, so that the stability of the purification column body 1 can be increased, and the purification column body cannot be deformed or broken even if a strong force is applied.
Optionally, at least three supporting protrusions are provided, and the supporting protrusions are uniformly arranged along the circumferential direction of the inner peripheral wall of the filter cavity. As shown in fig. 4, in the present embodiment, the number of the holding projections 2 is eight, and the eight holding projections 2 are arranged circumferentially along the inner peripheral wall of the filter chamber 13. Therefore, the supporting bulges 2 can play a better role in supporting the filter element 3, and on the other hand, the stability of the purification column body 1 can be further improved, so that the purification column body is not easy to break.
Alternatively, as shown in fig. 4 and 6, in the present embodiment, any two of the holding projections 2 do not contact, that is, a gap exists between any two of the holding projections 2. Thus, the waste liquid filtered by the filter element 3 has larger flow area and higher filtering efficiency when flowing through the cavity section where the supporting bulge 2 is located. Of course, any two or more holding projections 2 can be provided in contact.
Alternatively, as shown in fig. 4, in this embodiment, the supporting protrusion 2 is divided into a first protrusion 21 and a second protrusion 22, where the first protrusion 21 and the second protrusion 22 are provided in plural, and the first protrusions 21 and the second protrusions 22 are arranged alternately, and the projection of the first protrusion 21 along the axial direction of the purification column body 1 protrudes from the wall of the filter cavity 13 by M, and it should be understood that the point M is the distance between the point of the first protrusion 21 farthest from the wall of the filter cavity 13 and the wall of the filter cavity 13, and the projection of the second protrusion 22 along the axial direction of the purification column body 1 protrudes from the wall of the filter cavity 13 by N, where the point N is the distance between the point of the second protrusion 22 farthest from the wall of the filter cavity 13 and the wall of the filter cavity 13; wherein M > N. Based on this, the longer first protruding portion 21 plays a main supporting role, and the shorter second protruding portion 22 plays an auxiliary supporting role, and simultaneously, can provide a larger flow area, and reduce interference to effluent.
Optionally, as shown in fig. 6, in this embodiment, the area of the liquid inlet 11 is larger than the area of the liquid outlet 12, the filter cavity 13 includes a first cavity segment 131 and a second cavity segment 132 that are sequentially disposed, the first cavity segment 131 is communicated with the liquid inlet 11, the cross-sectional area of the first cavity segment 131 along the radial direction of the filter cavity 13 is unchanged, the second cavity segment 132 is communicated with the liquid outlet 12, and the cross-sectional area of the second cavity segment 132 along the radial direction of the filter cavity 13 is gradually reduced along the sample outlet direction. It should be understood that the sample outlet direction is the direction from the liquid inlet 11 toward the liquid outlet 12. Preferably, the bearing projection 2 is provided at the second chamber section 132. Thus, the position and the structural arrangement of the supporting bulge 2 are reasonable.
Optionally, as shown in fig. 8, in the present embodiment, the nucleic acid purification cartridge further includes a pressure ring 4, where the pressure ring 4 is disposed in the filter cavity 13 and is located on a side of the filter 3 away from the support protrusion 2, and the pressure ring 4 is configured to limit the filter to further move toward the liquid inlet 11. Based on this, the pressing ring 4 plays a limiting role, and prevents the filter sheet from separating from the purification column body 1 during the centrifugation step.
Alternatively, as shown in fig. 8, in the present embodiment, the outer peripheral wall of the pressing ring 4 has a plurality of abutment projections 41, the plurality of abutment projections 41 are uniformly distributed along the outer peripheral wall of the pressing ring 4, a notch portion 42 is formed between any two adjacent abutment projections 41, and the pressing ring 4 is interference-fitted with the cavity wall of the filter cavity 13 through the abutment projections 41. In this way, the notch 42 can provide a certain installation margin, and the difficult assembly phenomenon caused by the dimensional deviation due to the injection molding error of the parts is avoided.
Alternatively, as shown in fig. 2, 3 and 7, in the present embodiment, the nucleic acid purification cartridge further comprises a waste liquid tube 5, the waste liquid tube 5 is formed with a waste liquid port 51 through which the purification cartridge body 1 is inserted, at least two ribs 14 are provided on the outer peripheral wall of the purification cartridge body 1, the ribs 14 protrude outward in the radial direction of the purification cartridge body 1, the purification cartridge body 1 is interference fit with the inner wall of the waste liquid tube 5 through the ribs 14, and a gap is formed between the outer peripheral wall of the purification cartridge body 1 except the ribs 14 and the inner wall of the waste liquid tube 5. On the one hand, the ribs 14 can provide a certain assembly margin, so that the difficult assembly phenomenon caused by dimensional deviation due to part injection molding errors is avoided; on the other hand, because the outer peripheral wall of the purifying column body 1 has a gap between the position except the rib 14 and the inner wall of the waste liquid pipe 5, when the filtered waste liquid flows into the waste liquid pipe 5 from the liquid outlet 12, the air in the waste liquid pipe 5 can be discharged through the gap to balance the pressure inside and outside the waste liquid pipe 5, so that the flow of the waste liquid after the filtration of the filter sheet is smoother, and the filtration efficiency is improved.
Optionally, in this embodiment, the purification cartridge body 1 and/or the outer wall of the waste liquid tube 5 is provided with a frosting. Because the nucleic acid purification post is small, the setting of frosting is more favorable to the operator to hold fixedly.
Optionally, as shown in fig. 2 and 3, in the present embodiment, the purification column is further provided with an end cap 6, the end cap 6 is connected to the edge of the liquid inlet 11 through a connection portion 61 in a reversible manner, and the end cap 6 is used to open and close the liquid inlet 11. Specifically, the connection portion 61 is a connection piece or a connection plate or the like.
The application method of the nucleic acid purification column provided by the embodiment of the utility model comprises the following steps: the purification column body 1 is inserted into the waste liquid pipe 5, the liquid inlet 11 is opened by turning the end cover 6, the sample liquid is injected from the liquid inlet 11 and centrifuged, and filtered waste liquid flows out from the liquid outlet 12 into the waste liquid pipe 5.
In summary, the embodiment of the utility model provides a nucleic acid purification column, which mainly comprises a purification column body 1 and a filter element 3, wherein the purification column body 1 is formed with a liquid inlet 11 and a liquid outlet 12 which are oppositely arranged, the purification column body 1 is formed with a filter cavity 13 which is communicated with the liquid inlet 11 and the liquid outlet 12, the position of the filter cavity 13, which is close to the liquid outlet 12, is provided with at least two supporting bulges 2, the two supporting bulges 2 are arranged on the cavity wall of the filter cavity 13 and protrude inwards, the upper surfaces of the supporting bulges 2 are positioned on the same plane, and the filter element 3 is arranged in the filter cavity 13 and is propped against the supporting bulges 2. Compared with the prior art, the nucleic acid purification column has the following advantages:
1. the column body reinforcing rib of the reticular structure is replaced by the inward convex supporting bulge of the nucleic acid purification column, waste liquid filtered by the filter disc is not blocked by the reticular structure, the flow is smoother, the liquid outlet speed is higher when the centrifugal force is higher in the actual use process, the nucleic acid purification column can still maintain higher filtering efficiency, and the liquid outlet time is shorter. In addition, the supporting bulge also plays a role of supporting and reinforcing ribs, so that the stability of the purification column body can be improved, and the purification column body cannot be deformed or broken even if the purification column body is subjected to strong acting force.
2. The compression ring plays a limiting role and prevents the filter disc from separating from the purification column body and falling off during the centrifugation process.
3. The arrangement of the notch part can provide a certain installation margin, and the difficult assembly phenomenon caused by dimensional deviation due to part injection molding errors is avoided.
4. The ribs can provide a certain assembly margin, so that the phenomenon of difficult assembly caused by dimensional deviation due to injection molding errors of parts is avoided; secondly, because the clearance has between the outer peripheral wall of purification post body and the inner wall of waste liquid pipe except the rib, when the waste liquid after the filtration flows into the waste liquid pipe from the liquid outlet, the air accessible clearance in the waste liquid pipe is discharged, balances the pressure inside and outside the waste liquid pipe to make the waste liquid flow after the filter piece filters more smooth and easy, thereby improve filtration efficiency.
5. The purification post body and/or waste liquid pipe outer wall set up to the frosting, and the setting of frosting is more favorable to the operator to hold fixedly.
The foregoing is merely a preferred embodiment of the present utility model, and it should be noted that modifications and substitutions can be made by those skilled in the art without departing from the technical principles of the present utility model, and these modifications and substitutions should also be considered as being within the scope of the present utility model.
Claims (10)
1. A nucleic acid purification cartridge comprising:
the purification column comprises a purification column body, a liquid inlet and a liquid outlet, wherein the liquid inlet and the liquid outlet are oppositely arranged, and a filter cavity which is communicated with the liquid inlet and the liquid outlet is formed in the purification column body;
at least two bearing bulges are arranged at the position, close to the liquid outlet, of the filter cavity, the bearing bulges are arranged on the cavity wall of the filter cavity and protrude inwards, and the upper surfaces of the bearing bulges are positioned on the same plane;
the filter piece is arranged in the filter cavity and is propped against the supporting bulge.
2. The nucleic acid purification cartridge of claim 1, wherein:
the bearing bulges are at least three, and the bearing bulges are uniformly arranged along the circumferential direction of the inner peripheral wall of the filter cavity.
3. The nucleic acid purification cartridge of claim 1, wherein:
any two bearing bulges are not contacted.
4. The nucleic acid purification cartridge of claim 2, wherein:
the bearing bulge is divided into a first bulge and a second bulge, the first bulge and the second bulge are all arranged in a plurality, the first bulge and the second bulge are alternately arranged, the length of the first bulge along the axial projection of the purification column body, which is M, is the length of the filter cavity wall, and the length of the second bulge along the axial projection of the purification column body, which is N, M > N.
5. The nucleic acid purification cartridge of claim 1, wherein:
the area of the liquid inlet is larger than that of the liquid outlet;
the filter cavity comprises a first cavity section and a second cavity section which are sequentially arranged, the first cavity section is communicated with the liquid inlet, the cross-sectional area of the first cavity section is unchanged, the second cavity section is communicated with the liquid outlet, and the cross-sectional area of the second cavity section is gradually reduced along the sample outlet direction.
6. The nucleic acid purification cartridge according to claim 5, wherein:
the bearing bulge is arranged at the second cavity section.
7. The nucleic acid purification cartridge of claim 1, wherein:
the filter device further comprises a pressure ring, wherein the pressure ring is arranged in the filter cavity and is positioned on one side, away from the bearing protrusion, of the filter element, and the pressure ring is configured to limit the filter element to move further towards the liquid inlet.
8. The nucleic acid purification cartridge of claim 7, wherein:
the periphery wall of clamping ring has a plurality of butt protruding, and is a plurality of the butt protruding edge the periphery wall evenly distributed of clamping ring is formed with the breach portion between the butt protruding of arbitrary two adjacency, the clamping ring passes through the butt protruding with the chamber wall interference fit of filter chamber.
9. The nucleic acid purification cartridge of claim 1, wherein:
the purification column further comprises a waste liquid pipe, wherein the waste liquid pipe is provided with a waste liquid port into which the purification column body can be inserted;
the periphery wall distribution of purification post body is provided with two at least ribs, the rib is followed purification post body radially outwards outstanding, purification post body passes through the rib with the inner wall interference fit of waste liquid pipe, the periphery wall of purification post body except the rib the position with be formed with the clearance between the inner wall of waste liquid pipe.
10. The nucleic acid purification cartridge of claim 1, wherein:
the purification column is also provided with an end cover, the end cover is connected with the edge of the liquid inlet in a turnover way through a connecting part, and the end cover is used for opening and closing the liquid inlet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223472510.8U CN219174491U (en) | 2022-12-23 | 2022-12-23 | Nucleic acid purification column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223472510.8U CN219174491U (en) | 2022-12-23 | 2022-12-23 | Nucleic acid purification column |
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| Publication Number | Publication Date |
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| CN219174491U true CN219174491U (en) | 2023-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202223472510.8U Active CN219174491U (en) | 2022-12-23 | 2022-12-23 | Nucleic acid purification column |
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| CN (1) | CN219174491U (en) |
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