CN219128023U - Tumor electric field treatment system for laboratory mice - Google Patents

Abstract

The utility model provides a tumor electric field treatment system for an experimental mouse, which comprises an electric field generator and a plurality of electrode patch assemblies, wherein the electric field generator generates at least one pair of alternating electric signals with opposite polarities, the electrode patch assemblies are provided with a plurality of electrode patches which are arranged in pairs, the tumor electric field treatment system also comprises an adapter plate, the adapter plate comprises a printed circuit board, a plurality of input connectors and a plurality of output connectors, the input connectors are electrically connected with the electric field generator and are respectively connected with different alternating electric signals, the output connectors are electrically connected with the electrode patch assemblies, a plurality of conductive traces connected between the input connectors and the output connectors are embedded in the printed circuit board, and the input connectors are respectively connected with the output connectors in parallel through corresponding conductive traces. The system can simultaneously carry out experiments on a plurality of experimental mice under the condition of completely identical alternating electric signals so as to carry out control experiments, improve the accuracy and the effectiveness of the experiments, adopt the adapter plate for switching, and have a simpler structure.

Description

Tumor electric field treatment system for laboratory mice

Technical Field

The utility model relates to a tumor electric field treatment system, in particular to a tumor electric field treatment system for an experimental mouse.

Background

Tumor therapeutic electric fields (TTFields) can affect tubulin aggregation, inhibit spindle formation, inhibit mitotic progression, and induce apoptosis in cancer cells. The low-intensity, medium-frequency and alternating electric field is used for intervention treatment of various tumor diseases, and is a clinically effective cancer treatment method. Many basic studies have been made at home and abroad to demonstrate the biological effects of TTFields. The research results in animal experiments show that TTFields can effectively inhibit tumor angiogenesis in tumor-bearing mice and inhibit the growth of tumors in the mice. At present, the clinical research results at home and abroad also prove the positive effect of TTFields on tumor treatment. CANCER RESEARCH 64,3288, 3288-3295 in Disruption of Cancer Cell Replication by Alternating Electric Fields published 5/1 2004, basic studies have demonstrated in vitro experiments that electric fields can interfere with mitosis.

In order to study the therapeutic effect of TTFields on head tumors, a large number of animal experiments are required to conduct basic studies on head tumors. The existing tumor electric field treatment system for the laboratory mice comprises an electric field generator and a pair of electrode patches, wherein the electrode patches are attached to the head of the laboratory mice in a squirrel cage, and alternating electric signals applied to the electrode patches by the electric field generator form an alternating electric field acting on the head of the laboratory mice. However, the system only has one pair of electrode patches, and a control experiment cannot be performed on a plurality of experimental mice at the same time. If multiple rats are used for control experiments, multiple electric field generators are required. It is difficult to keep the alternating electric signals generated by different electric field generators completely consistent, resulting in inaccurate results of control experiments performed simultaneously for a plurality of experimental mice.

Thus, there is a need for improvements to existing tumor electric field therapy systems for laboratory mice.

Disclosure of Invention

The utility model provides a tumor electric field treatment system for an experimental mouse, which has a simple structure and can simultaneously carry out a plurality of groups of control experiments.

The tumor electric field treatment for the experimental mice is realized by the following technical scheme: the utility model provides a tumour electric field treatment system for laboratory mouse, includes electric field generator and a plurality of electrode patch subassembly, electric field generator produces at least a pair of polarity opposite alternating electric signal, electrode patch subassembly is equipped with a plurality of electrode patches that set up in pairs, still includes the keysets, the keysets includes printed circuit board, a plurality of input connector and a plurality of output connector, a plurality of input connector with electric field generator electric connection and access respectively different alternating electric signal, output connector with electrode patch subassembly electric connection, the printed circuit board is embedded to be equipped with a plurality of conductive trace that connect between input connector and output connector, a plurality of input connector are connected a plurality of output connectors through corresponding conductive trace parallel respectively.

Further, the output connector is provided with at least one output terminal, and the input connector is connected with one output terminal of a part of the output connectors in parallel through the corresponding conductive trace or is connected with a plurality of output terminals of all the output connectors in parallel through the corresponding conductive trace.

Further, the number of the input connectors is the same as the kind of the alternating electric signal.

Further, the logarithm of the electrode patches of the electrode patch assembly is the same as the logarithm of the alternating electrical signal.

Further, the electric field generator generates a pair of alternating electric signals with opposite polarities, the adapter plate is provided with a pair of input connectors, and the electrode patch assembly is provided with a pair of electrode patches.

Further, the adapter plate further comprises a bracket for supporting the printed circuit board.

Further, the adapter plate is provided with a plurality of layers of printed circuit boards.

Further, the output connector is further provided with a reserved terminal.

Further, the electrode patch includes the electrode patch, a docking connector, and a wire connecting the electrode patch and the docking connector, and the docking connector is docked with the output connector.

Further, the wires comprise a plurality of first wires, a plurality of second wires and a conductive slip ring which is electrically connected with the first wires and the second wires in a rotatable manner, the other ends of the first wires are electrically connected with the butt connector, and the other ends of the second wires are electrically connected with the electrode patches.

Further, the electrode patch comprises a backing, an electrical functional component adhered on the backing and an adhesive piece covering the electrical functional component, wherein the backing is provided with a circular body part and a plurality of strip parts, and the strip parts uniformly and outwards extend in an emission shape along the periphery of the body part.

Further, the electrical functional component comprises a flexible circuit board, a dielectric element and an insulating board, wherein the flexible circuit board comprises a main body part and a wiring part which is laterally extended from the main body part, the main body part is provided with a conductive electric core on one side face of the main body part facing the adhesive piece, the dielectric element and the conductive electric core are welded and fixed on the main body part, and the insulating board is fixed on the other side face of the main body part facing the back lining; the wiring portion is provided with a conducting strip electrically connected with the conducting cell, the conducting strip is connected with the second wire in a welded mode, and a heat sealing sleeve is arranged at the welding position in a coating mode.

Further, a metal layer is arranged on one surface of the dielectric element facing the main body part, and the metal layer is connected with the conductive electric core in a welding way.

Further, the electrical functional assembly further comprises a supporting plate, and the supporting portion corresponds to the conductive sheet and is arranged on two opposite sides of the wiring portion respectively.

The tumor electric field treatment system for animal experiments converts at least one pair of alternating electric signals with opposite polarities generated by the electric field generator into parallel multiple groups of outputs by the adapter plate, and can synchronously perform control experiments so as to improve the accuracy and the effectiveness of basic research data and conclusions of animal experiments.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the utility model as claimed.

Drawings

Fig. 1 is a block diagram of a tumor electric field therapy system for laboratory mice according to one embodiment of the present utility model.

Fig. 2 is a perspective view of the patch panel of the tumor electric field therapy system for laboratory mice of fig. 1.

Fig. 3 is another angular perspective view of the adapter plate of fig. 2.

Fig. 4 is a perspective view of the electrode patch assembly of the tumor electric field treatment system for laboratory mice of fig. 1.

Fig. 5 is a plan view of the electrode patch assembly of fig. 4.

Fig. 6 is a partially exploded perspective view of the electrode patch assembly of fig. 4.

Fig. 7 is an exploded perspective view of the electrode patch of fig. 6.

Fig. 8 is a block diagram of a tumor electric field therapy system for laboratory mice according to another embodiment of the present utility model.

Fig. 9 is a perspective view of the patch panel of the tumor electric field therapy system for laboratory mice of fig. 8.

Fig. 10 is another angular perspective view of the adapter plate of fig. 9.

Reference numerals illustrate:

tumor electric field treatment systems 1000, 1000'; electrode patch assemblies 100, 100'; an electrode patch 1; a backing 11; a main body 111; a strap portion 112; an electrical functional component 12; a flexible wiring board 121; a dielectric element 122; an insulating plate 123; a main body 124; a wiring portion 125; a conductive cell 126; a conductive sheet 127; a support plate 128; an adhesive member 13; a mating connector 2; a wire 3; a first wire 31; a second wire 32; a conductive slip ring 33; a heat-shrinkable sleeve 4; an adapter plate 200; a printed circuit board 201; an input connector 202; an output connector 203; a bracket 204; an input terminal 205; an output terminal 206; reserved terminals 207; electric field generators 300, 300'; adapters 400, 400'.

Detailed Description

Reference will now be made in detail to exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, the same numbers in different drawings refer to the same or similar elements, unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present utility model. Rather, they are merely examples of apparatus, systems, devices, and methods that are consistent with aspects of the utility model.

Referring to fig. 1 to 7, the present utility model relates to a tumor electric field treatment system 1000 for laboratory mice, which includes an electric field generator 300, an adapter 400, a plurality of electrode patch assemblies 100, and an adapter plate 200. The electrode patch assembly 100 is provided with a pair of electrode patches 1 attached to the head of a laboratory mouse, and the electric field generator 300 applies an alternating electric field between each pair of electrode patches 1 through the adapter 400 and the adapter plate 200, and acts on the head of the laboratory mouse, thereby being capable of being used for performing a brain tumor treatment experiment. In this embodiment, the adaptor board 200 is electrically connected to the electric field generator 300 through the adaptor 400, and as a simple alternative, the adaptor 400 may be omitted, i.e. the electric field generator 300 is directly electrically connected to the adaptor board 200.

The electric field generator 300 produces a set of alternating electrical signals of opposite polarity. In the present embodiment, the electric field generator 300 generates a pair of alternating electric signals X1 and X2 with opposite polarities and continuously applied. The frequency range of the alternating electric signal is between 150kHz and 300kHz, the intensity of the alternating electric signal is not less than 20Vpp, and the application time of the alternating electric signal is not less than 72H. The alternating electric signals X1 and X2 of the electric field generator 300 are separately output according to polarities, the adapter plate 200 converts the alternating electric signals X1 and X2 into a plurality of groups of alternating electric signals, each group of alternating electric signals comprises alternating electric signals X1 and X2 with opposite polarities, and experiments under the same condition can be simultaneously carried out on a plurality of experimental mice, so that control experiments can be carried out, and the accuracy and the effectiveness of basic research data and conclusions of animal experiments are improved.

Referring to fig. 2 and 3, the interposer 200 includes a printed circuit board 201, a plurality of input connectors 202, a plurality of output connectors 203, and a bracket 204 supporting the printed circuit board 201. The input connector 202 and the output connector 203 are respectively located on two opposite sides of the printed circuit board 201, and conductive traces (not shown) connecting the input connector 202 and the output connector 203 are embedded in the printed circuit board 201. The plurality of input connectors 202 are connected in parallel to the plurality of output connectors 203 by respective conductive traces (not shown). The input connector 202 is electrically connected to the adapter 400 through connector plug, and the output connector 203 is electrically connected to the electrode patch assembly 100 through connector plug, so as to realize transmission of alternating electric signals. In the present embodiment, the patch panel 200 includes a printed circuit board 201, and the printed circuit board 201 is provided with two input connectors 202, each input connector 202 includes 10 input terminals 205, and the patch panel 400 inputs an alternating electrical signal X1 through one input connector 202 and an alternating electrical signal X2 through the other input connector 202. The printed circuit board 201 is provided with 10 output connectors 203, each output connector 203 is provided with two output terminals 206 and one reserved terminal 207, the two output terminals 206 are respectively electrically connected with a corresponding one of the input terminals 205 of the two input connectors 202 through two conductive traces (not shown), and the corresponding input terminals 205 of the two input connectors 202 are electrically connected with the adapter 400 to respectively transmit alternating electric signals X1 and X2. In this embodiment, each input connector 202 is connected in parallel to a corresponding output terminal 206 of all output connectors 203 through a corresponding conductive trace (not shown). Reserved terminal 207 may not be energized by a signal or may be used to configure a temperature monitoring circuit. The input terminal 205 of the input connector 202, which does not pass the alternating electrical signal X1 or X2, is adaptable to the reserved terminal 207 for configuring the temperature monitoring circuit. The adapter plate 200 converts the mutually independent alternating electric signals X1 and X2 into a plurality of groups of alternating electric signals, wherein each group comprises alternating electric signals X1 and X2, and each group of alternating electric signals are in parallel connection and mutually independent. The electrode patch assembly 100 includes a pair of electrode patches 1, and the two electrode patches 1 receive alternating electric signals x1, x2, respectively, and then an alternating electric field of a first direction is generated between the pair of electrode patches 1. The patch panel 200 converts a pair of alternating electrical signals with opposite polarities provided by the electric field generator 300 into a plurality of sets of parallel alternating electrical signals through the input connector 202 and the output connector 203, and each set includes the pair of alternating electrical signals with opposite polarities and transmits the alternating electrical signals to each electrode patch assembly 100. The tumor electric field treatment system 1000 for the experimental mice can simultaneously perform experiments under the same condition aiming at a plurality of experimental mice so as to perform control experiments and improve the accuracy and the effectiveness of basic research data and conclusions of animal experiments; and the adapter plate 200 is adopted for switching, so that the structure is simpler than a complex cable type connecting structure. In other embodiments, each output connector 203 of the printed circuit board 201 is provided with 1 output terminal 206 and two reserved terminals 207. Each output connector 203 connects in parallel 1 output terminal 206 of a part of the output connectors 203. For example: two opposite sides of the printed circuit board 201 are respectively provided with 2 input connectors 202 and 10 output connectors 203. The output terminals 206 of the 5 output connectors 203 are electrically connected to a corresponding one of the input terminals 205 of the same input connector 202 through one conductive trace (not shown), and the output terminals 206 of the remaining 5 output connectors 203 are electrically connected to a corresponding one of the input terminals 205 of the other input connector 202 through one conductive trace (not shown), respectively, and a pair of alternating electrical signals X1, X2 of opposite polarities transmitted from the adapter 400 to the adapter board 200 are transmitted through the 5 output connectors 203 in parallel by 5 paths, respectively.

It should be understood that each input connector 202 is connected to a different alternating signal, so the number of input connectors 202 is the same as the type of alternating signals, the number of input connectors 202 can be set corresponding to the number of alternating signals, in this embodiment, the electric field generator 300 generates a pair of alternating signals with opposite polarities, so the number of input connectors 202 is 2; the number of the output connectors 203 is more than 2, and more than 2 electrode patch assemblies 100 are correspondingly connected, so that a plurality of groups of control experiments can be performed. The number of input terminals 205 of the input connector 202 is the same as the kind of alternating electrical signals so as to output a complete set of alternating electrical signals. The logarithm of the electrode patches 1 in the electrode patch assembly 100 is the same as the logarithm of the alternating electrical signal.

The number of input terminals 205 and the number of output terminals 206 do not need to be the same, and one input terminal 205 may be connected to a plurality of output terminals 206 by a plurality of conductive traces (not shown).

Referring to fig. 4 and 5, the electrode patch assembly 100 includes the electrode patch 1, the mating connector 2, and the lead 3 connecting the electrode patch 1 and the mating connector 2. The electric field generator 300 inputs alternating electric signals of opposite polarities to each pair of electrode patches 1 through the adapter 400, the adapter plate 200 and the docking connector 2, respectively, to form an alternating electric field between the pair of electrode patches 1. In the present embodiment, the electrode patch assembly 100 is provided with only a pair of electrode patches 1.

The lead 3 includes a plurality of first leads 31, a plurality of second leads 32, and a rotatable conductive slip ring 33 electrically connected to the first leads 31 and the second leads 32, wherein the other end of the first leads 31 is electrically connected to the mating connector 2, and the other end of the second leads 32 is electrically connected to the electrode patch 1. The conductive slip ring 33 is fixedly arranged on a mouse cage (not shown), and the first wire 31 and the second wire 32 can rotate around the central axis of the conductive slip ring 33 without interlacing the second wire 32, so that the influence of normal movement caused by interlacing the second wire 32 when the experimental mouse moves in the mouse cage can be prevented. The first wires 31 and the second wires 32 are arranged in one-to-one correspondence, the number of the first wires 31 and the second wires 32 corresponds to the number of the electrode patches 1, in this embodiment, the electrode patch assembly 100 is provided with a pair of electrode patches 1, and each of the first wires 31 and the second wires 32 has two wires for respectively transmitting a pair of alternating electric signals X1 and X2 with opposite polarities. In this embodiment, the first conductive wires 31 are two side-by-side wires.

The butt connector 2 is plugged with the output connector 203 of the adapter board 200 to realize electrical connection, the butt connector 2 is provided with conductive terminals (not shown) arranged in pairs, the number of the conductive terminals is identical to that of the electrode patches 1 in the electrode patch assembly 100, in this embodiment, two conductive terminals of the butt connector 2 are respectively connected with two output terminals 206 of the output connector 203 correspondingly, and alternating electrical signals x1 and x2 are respectively transmitted. In other embodiments, the mating connector 2 comprises two separate mating connectors 2 each having one conductive terminal, each of which is plugged into a respective one of the two output terminals 206 that carry two alternating electrical signals X1, X2 of opposite polarity.

The other end of the second wire 32 is welded with the electrode patch 1, and the periphery of the welding part is coated by the heat shrinkage sleeve 4, so that the welding part of the second wire 32 and the electrode patch 1 can be insulated and protected, and the welding part is prevented from being exposed and being contacted with other conductive substances to be short-circuited. The heat shrinkage bush 4 also provides strength support for the welding part, avoids the fracture of the welding part, and can play a role in dust prevention and water prevention.

As shown in fig. 6, the electrode patch 1 includes a backing 11, an electrical functional component 12 attached to the backing 11, and an adhesive member 13 covering the electrical functional component 12. The adhesive member 13 has double-sided adhesive properties, and when in use, is applied as an adhesive layer to a corresponding portion of a mouse head, the backing 11 further firmly positions the corresponding electrical functional component 12 on the mouse head, and applies an alternating electric field to the mouse head to treat tumors. The adhesive means 13 is adapted to keep the skin surface moist and to relieve local pressure, preferably the adhesive means 13 is a conductive hydrogel and may act as a conductive medium.

The backing 11 is a mesh fabric, preferably a nonwoven fabric. The front face of the backing 11 has a biocompatible adhesive by which the electrical functional component 12 is adhered to the body portion 111. The backing 11 has a circular body portion 111 and a plurality of strip portions 112, the plurality of strip portions 112 extending uniformly and radially outwardly along the periphery of the body portion 111, the strip portions 112 having a length to be windable and fixable so as to better fix the electrode patch 1 to the head of the laboratory mouse. In this embodiment, the backing 11 is provided with 4 strip portions 112 arranged in a cross-like shape.

Referring to fig. 7, the electrical function assembly 12 includes a flexible circuit board 121, and dielectric elements 122 and insulating plates 123 respectively disposed on opposite sides of the flexible circuit board 121. The flexible circuit board 121 includes a main body 124 and a wiring portion 125 extending laterally from the main body 124. The main body 124 is horizontally flat, and the dielectric element 122 and the insulating plate 123 are disposed in one-to-one correspondence with the main body 124. The dielectric element 122 is provided on the front surface of the main body 124, and the insulating plate 123 is provided on the rear surface of the main body 124. The centers of the main body 124, the insulating plate 123, and the dielectric element 122 are positioned on the same straight line. In the present embodiment, the main body 124, the insulating plate 123, and the dielectric element 122 are all circular sheet-like structures. The body 111 of the backing 11 has a larger diameter than the body 124, and the electrical function module 12 is attached to the body 111 of the backing 11 with the body 124 centered, and the connection portions 125 are offset from the strip portions 112 of the backing 11. The upper surface of the main body 124 is provided with a circular conductive cell 126; the wiring portion 125 has a bar shape, and the upper surface of the end of the wiring portion 125 remote from the main body portion 124 is provided with a conductive sheet 127, and the conductive cell 126 and the conductive sheet 127 are connected in series by a conductive trace (not shown) embedded in the flexible wiring board 121. The aforementioned welding connection between the electrode patch 1 and the second wire 32, that is, the welding connection between the conductive sheet 127 of the connection portion 125 and the second wire 32, can realize the electrical connection between the electrode patch 1 and the wire 3.

The dielectric element 122 is electrically connected to the conductive core 126 of the main body 124 through the conductive adhesive material, so that the pair of electrode patches 1 respectively transmit the alternating electric signals x1 and x2 generated by the electric field generator 300 to the head of the mouse through the dielectric element 122, and an alternating electric field for tumor electric field therapy is formed between the two electrode patches 1. The conductive bonding material is soldering tin material or conductive adhesive. The dielectric element 122 is made of a high dielectric constant material, and has a conductive property of blocking the conduction of direct current and allowing the alternating current to pass through, so as to ensure the safety of the laboratory mice. In the present embodiment, the dielectric element 122 is a dielectric ceramic sheet. The dielectric element 122 is attached with an annular metal layer (not shown) on the bottom surface of the main body 124 facing the flexible circuit board 121, and the metal layer (not shown) is connected with the conductive core 126 of the main body 124 by soldering, so that high soldering alignment precision is not required, and soldering is more convenient. The space is left between the edge of the metal layer and the edge of the dielectric element 122, that is, the diameter of the metal layer (not shown) is smaller than the diameter of the dielectric element 122, so that the solder between the dielectric element 122 and the main body 124 overflows to the outside of the main body 124 when being heated and melted, and the direct current which is not blocked by the dielectric element 122 passes through and acts on the body surface of a patient when the electrode patch 1 is applied to the body surface of a tumor part of an experimental mouse, thereby causing discomfort.

The insulating plate 123 is adhered to the back surface of the main body 124 facing the backing 11 by an adhesive, so that the strength of the main body 124 can be enhanced, a flat welding plane is provided for the welding operation between the main body 124 and the dielectric element 122, and the product yield is improved. Meanwhile, the insulating plate 123 can also isolate the moisture in the air of the electrode patch 1 far away from the skin from contacting with the solder (not shown) between the main body 124 and the dielectric element 122, so as to avoid the moisture from corroding the solder (not shown) between the main body 124 and the dielectric element 122 and affecting the electrical connection between the main body 124 and the dielectric element 122. The thickness of the insulating plate 123 is 0.1-0.5 mm, in this embodiment, the thickness of the insulating plate 123 is 0.15mm, so that the electrical functional component 12 can be thinned, and the electrode patch 1 is applied in a manner suitable for animal experiments. The insulating plate 123 may be made of polyimide material, and has excellent mechanical properties and flexibility.

The electrical functional assembly 12 further comprises a supporting plate 128 arranged on the bottom surface of the wiring portion 125, the center of the supporting plate 128 is approximately aligned with the center of the conductive sheet 127, and the bottom side supports the wiring portion 125 to be provided with the conductive sheet 127, so that the strength of the wiring portion 125 can be improved, and the welding operation of the wiring portion 125 and the second conducting wire 32 is facilitated. The support plate 128 may be as wide as the wiring portion 125, and the length of the support plate 128 is greater than the length of the conductive sheet 127. The supporting plate 128 and the insulating plate 123 are both used for supporting, so that the local mechanical strength of the flexible circuit board is improved, and the material of the supporting plate 128 and the material of the insulating plate 123 can be the same, and the thickness can also be the same.

The diameter of the main body 124 is in the range of 6 to 12mm, preferably 6.7mm, and the diameter of the insulating plate 123 is substantially the same as the diameter of the main body 124. The diameter of the dielectric element 122 is slightly smaller than the diameter of the body portion 124, and the diameter of the dielectric element 122 is in the range of 4 to 10mm, preferably 6mm. The arrangement can make the electric functional component 12 light and thin, so as to adapt to animal experiments and be beneficial to the application of the electrode patch 1. The length of the wiring portion 125 is 20 to 100mm, preferably 38mm; the width of the wiring portion 125 is 1 to 5mm, preferably 2mm. The size of the wiring portion 125 may be set according to the size of an experimental mouse in order to better fix the electrode patch 1 to the head of the mouse.

Referring to fig. 8 to 10, another embodiment is a frame diagram of a tumor electric field therapy system 1000 'for a laboratory mouse, wherein the tumor electric field therapy system 1000' for a laboratory mouse includes an electric field generator 300 'alternately generating at least two sets of alternating electric signals with opposite polarities, an adapter 400' electrically connected to the electric field generator 300', an adapter plate 200' electrically connected to the adapter 400', and a plurality of sets of electrode patch assemblies 100'. In this embodiment, the electric field generator 300' generates a pair of alternating electric signals X1 and X2 with opposite electrical characteristics in a first period of time, and generates another pair of alternating electric signals Y1 and Y2 with opposite electrical characteristics in a second period of time, wherein the first period of time and the second period of time both last for 0.5-5s, and the switching interval between the first period of time and the second period of time is not more than 10ms. Accordingly, the four alternating electrical signals X1, X2, Y1, Y2 are respectively input to the adapter board 200 'by the adapter 400', the adapter board 200 'converts the alternating electrical signals X1, X2, Y1, Y2 into a plurality of groups by four input connectors (not shown), each group comprises the four alternating electrical signals X1, X2, Y1, Y2, the group of alternating electrical signals X1, X2, Y1, Y2 is transmitted to the electrode patch assembly 100' comprising at least two pairs of electrode patches (not shown) by a plurality of output connectors (not shown), one pair of electrode patches (not shown) respectively receives the alternating electrical signals X1, X2, then an electric field in a first direction is generated between the pair of electrode patches (not shown), the other pair of electrode patches (not shown) respectively receives the alternating electrical signals Y1, Y2, and an electric field in a second direction is generated between the pair of electrode patches (not shown). Preferably, the second direction is perpendicular to the first direction.

The electrode patch (not shown) in the present embodiment is the same as the electrode patch 1 in the first embodiment. The electrode patch assembly 100 'in the present embodiment has two pairs of electrode patches (not shown) and 4 conductive terminals (not shown) respectively connected to the interposer 200' and transmitting alternating electrical signals x1, x2, y1, y2. Referring to fig. 9 and 10, in the present embodiment, the interposer 200' includes at least two layers of printed circuit boards 201, a plurality of input connectors 202 and a plurality of output connectors 203 respectively located on each layer of printed circuit boards 201, and a bracket 204 supporting the printed circuit boards 201. In this embodiment, a total of 4 input connectors 202 transmit alternating electrical signals X1, X2, Y1, Y2. The plurality of output connectors 203 on each layer of the printed circuit board 201 multiplex and output the alternating electrical signals transmitted on the same printed circuit board 201 to the corresponding electrode patch assemblies 100' in parallel.

In other embodiments, the electric field generator 300' also generates three or more sets of alternating electric signals with opposite polarities, which are not described herein.

The tumor electric field treatment system 1000, 1000' for animal experiments converts at least one pair of alternating electric signals with opposite polarities generated by the electric field generators 300, 300' into parallel multi-group output by the adapter plates 200, 200', and can synchronously perform control experiments so as to improve the accuracy and the effectiveness of basic research data and conclusions of animal experiments; the electrode patch assemblies 100 and 100' of the tumor electric field treatment system are lighter, thinner and miniaturized and can adapt to animal experiments, and the electrode patch assembly is favorable for the application of the electrode patch 1.

The foregoing description of the preferred embodiments of the utility model is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the utility model.

Claims (14)

1. The utility model provides a tumour electric field treatment system for laboratory mouse, includes electric field generator and a plurality of electrode patch subassembly, electric field generator produces at least a pair of polarity opposite alternating electric signal, electrode patch subassembly is equipped with a plurality of electrode patches that set up in pairs, its characterized in that: the electric field generator comprises an electric field generator, and is characterized by further comprising an adapter plate, wherein the adapter plate comprises a printed circuit board, a plurality of input connectors and a plurality of output connectors, the input connectors are electrically connected with the electric field generator and are respectively connected with different alternating electric signals, the output connectors are electrically connected with the electrode patch assembly, a plurality of conductive traces connected between the input connectors and the output connectors are embedded in the printed circuit board, and the input connectors are respectively connected with the output connectors in parallel through corresponding conductive traces.

2. The oncological electric field treatment system for laboratory mice of claim 1, wherein: the output connector is provided with at least one output terminal, and the input connector is connected with one output terminal of part of the output connectors in parallel through corresponding conductive traces or is connected with a plurality of output terminals of all the output connectors in parallel through corresponding conductive traces.

3. The oncological electric field treatment system for laboratory mice of claim 1, wherein: the number of the input connectors is the same as the kind of the alternating electric signal.

4. A tumor electric field therapy system for laboratory mice as claimed in claim 3, wherein: the logarithm of the electrode patches of the electrode patch assembly is the same as the logarithm of the alternating electrical signal.

5. The oncological electric field treatment system for laboratory mice of claim 1, wherein: the electric field generator generates a pair of alternating electric signals with opposite polarities, the adapter plate is provided with a pair of input connectors, and the electrode patch assembly is provided with a pair of electrode patches.

6. The oncological electric field treatment system for laboratory mice of claim 1, wherein: the interposer further includes a support that supports the printed circuit board.

7. The oncological electric field treatment system for laboratory mice of claim 1, wherein: the adapter plate is provided with a plurality of layers of printed circuit boards.

8. The oncological electric field treatment system for laboratory mice of claim 1, wherein: the output connector is also provided with a reserved terminal.

9. The oncological electric field treatment system for laboratory mice of claim 1, wherein: the electrode patch comprises the electrode patch, a butt connector and a wire for connecting the electrode patch and the butt connector, and the butt connector is in butt joint with the output connector.

10. The oncological electric field treatment system for laboratory mice of claim 9, wherein: the lead comprises a plurality of first leads, a plurality of second leads and a conductive slip ring which is rotationally and electrically connected with the first leads and the second leads, the other ends of the first leads are electrically connected with the butt connector, and the other ends of the second leads are electrically connected with the electrode patches.

11. The oncological electric field treatment system for laboratory mice of claim 10, wherein: the electrode patch comprises a back lining, an electric functional component and an adhesive piece, wherein the electric functional component is adhered to the back lining, the adhesive piece covers the electric functional component, the back lining is provided with a circular body part and a plurality of strip parts, and the strip parts uniformly and outwards extend in an emission mode along the periphery of the body part.

12. The oncological electric field treatment system for laboratory mice of claim 11, wherein: the electric functional component comprises a flexible circuit board, a dielectric element and an insulating plate, wherein the flexible circuit board comprises a main body part and a wiring part which is laterally extended from the main body part, a conductive electric core is arranged on one side surface of the main body part facing the adhesive piece, the dielectric element and the conductive electric core are welded and fixed on the main body part, and the insulating plate is fixed on the other side surface of the main body part facing the back lining; the wiring portion is provided with a conducting strip electrically connected with the conducting cell, the conducting strip is connected with the second wire in a welded mode, and a heat sealing sleeve is arranged at the welding position in a coating mode.

13. The oncological electric field treatment system for laboratory mice of claim 12, wherein: a metal layer is arranged on one surface of the dielectric element, which faces the main body part, and the metal layer is connected with the conductive electric core in a welding way.

14. The oncological electric field treatment system for laboratory mice of claim 12, wherein: the electric functional component further comprises a supporting plate, wherein the supporting plate corresponds to the conductive sheet, and the supporting plate and the conductive sheet are respectively arranged on two opposite sides of the wiring part.

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