CN114272513A - Tumor electric field treatment system and electrode plate thereof - Google Patents
Tumor electric field treatment system and electrode plate thereof Download PDFInfo
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- CN114272513A CN114272513A CN202111578521.1A CN202111578521A CN114272513A CN 114272513 A CN114272513 A CN 114272513A CN 202111578521 A CN202111578521 A CN 202111578521A CN 114272513 A CN114272513 A CN 114272513A
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Abstract
The invention provides a tumor electric field treatment system and an electrode plate thereof, which are used for carrying out electric field treatment on a trunk tumor part of a patient during tumor electric field treatment and comprise a plurality of electrode units which are arranged in an array, a plurality of connecting parts for connecting two adjacent electrode units and leads which are electrically connected with the electrode units, wherein at least 10 electrode units are distributed in a matrix which is at least three rows and four columns, the electrode units are all connected with at least two adjacent electrode units, and at least one two adjacent electrode units in the electrode units are arranged in a spaced row or spaced column shape. The electrode slice applies the alternating electric field to the tumor part of the patient through at least 10 electrode units to carry out tumor treatment, can avoid the influence of insufficient electric field treatment on the treatment effect caused by the difference of the size, the position and the position of the tumor, increases the coverage area of the electrode slice, enhances the electric field intensity applied to the tumor part and improves the treatment effect.
Description
Technical Field
The invention relates to an electric field tumor treatment system and an electrode plate thereof, belonging to the technical field of medical instruments.
Background
At present, the treatment modes of tumors mainly comprise operations, radiotherapy, chemotherapy and the like, but the methods have corresponding defects, for example, radiotherapy and chemotherapy can generate side effects and kill normal cells. The electric field for Treating Tumor is also one of the current development fronts, and the electric field for Treating Tumor (TTF) is a method for applying an alternating electric field with low intensity and medium frequency to cancer cells, thereby interfering the mitosis process of the cancer cells, inhibiting the mitosis of the cancer cells, inducing the apoptosis of the cancer cells and achieving the treatment effect. Research shows that the electric field treatment has obvious effect in treating diseases such as glioblastoma, non-small cell lung cancer, malignant pleural mesothelioma and the like, and the electric field applied by the method can influence the aggregation of tubulin of the dividing cancer cells, prevent the formation of spindles of the dividing cancer cells, inhibit the mitotic process of the cancer cells and induce the apoptosis of the cancer cells.
The tumor electric field treatment system mainly comprises an electric field generator and an electrode plate electrically connected with the electric field generator. The electrode sheet is pasted on the skin of the corresponding part of the human body with the tumor so as to apply an alternating electric field to the tumor part for electric field tumor treatment. Because of the difference of the patients' bodies, the difference of the tumor positions, the tumor positions and the sizes of the tumors, when the electrode plate disclosed in the prior Chinese patent publication No. 112717272 is used for treatment, the electric field intensity applied to the tumor position through the electrode plate for treatment is insufficient, or the electric field does not cover the tumor part area, thereby affecting the treatment effect.
Therefore, there is a need to provide an improved electrode plate and tumor electric field treatment system to solve the problems in the background art.
Disclosure of Invention
The invention provides an electrode plate suitable for electric field treatment of trunk tumors and an electric field treatment system for tumors.
The electrode plate is realized by the following technical scheme: an electrode slice is used for carrying out electric field treatment on a trunk tumor part of a patient during electric field treatment of tumors and comprises a plurality of electrode units which are arranged in an array mode, a plurality of connecting parts for connecting two adjacent electrode units and wires which are electrically connected with the electrode units, wherein the electrode units are at least 10 and are distributed in an area which is at least three rows and four columns, each electrode unit is connected with at least two adjacent electrode units, and at least one adjacent two electrode units in the electrode units are arranged in a spaced row or spaced column mode.
Furthermore, at least one adjacent two electrode units in the plurality of electrode units are arranged in a disconnected state, and an interval between the two adjacent electrode units arranged in the disconnected state is formed.
And the wire connecting part is electrically connected with the connecting part or the electrode unit, penetrates through the interval and is welded with the lead.
Furthermore, the two adjacent electrode units arranged in rows are arranged in a spaced row, and at least two adjacent electrode units arranged in a same row in the plurality of electrode units arranged in rows are arranged in a spaced row.
Further, the spacing between two adjacent electrode units arranged in a row is the same, and the spacing between two adjacent electrode units arranged in a column is different.
Further, the connecting parts between two adjacent electrode units in the same row have the same length, and the connecting parts between two adjacent electrode units in the same column have different lengths.
Furthermore, the number of the electrode units is 13, and the electrode units are distributed in an area which is arranged in five rows and five columns.
Furthermore, at least one adjacent two electrode units in the plurality of electrode units arranged in rows are arranged in a spaced row, and the plurality of electrode units arranged in rows are all arranged in adjacent rows.
Further, the spacing between two adjacent electrode units arranged in a row is different, and the spacing between two adjacent electrode units arranged in a column is the same.
Further, the connecting parts between two adjacent electrode units in the same row have different lengths, and the connecting parts between two adjacent electrode units in the same column have the same length.
Furthermore, the number of the electrode units is 13, and the electrode units are distributed in an area which is arranged in three rows and five columns.
Furthermore, the connecting part comprises a first connecting part for connecting two adjacent electrode units in the same row and a second connecting part for connecting two adjacent electrode units in the same column.
Furthermore, the connecting part also comprises a third connecting part which is connected between two adjacent electrode units which are positioned in adjacent rows and adjacent columns and arranged in a diagonal shape.
Further, the third connecting portion has a length greater than that of the first connecting portion.
Further, the length of the third connecting portion is greater than half of the length of the first connecting portion.
Further, the length of the third connecting portion is greater than the length of the second connecting portion.
The invention also provides a tumor electric field treatment system which comprises an electric field generator and the electrode plate electrically connected with the electric field generator.
The electrode slice applies the alternating electric field to the tumor part of the patient through at least 10 electrode units to carry out tumor treatment, can avoid the influence of insufficient electric field treatment on the treatment effect caused by the difference of the size, the position and the position of the tumor, increases the coverage area of the electrode slice, enhances the electric field intensity applied to the tumor part and improves the treatment effect.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed.
Drawings
Fig. 1 is a perspective view of the electrode sheet of the first embodiment of the tumor electric field treatment system of the present invention.
Fig. 2 is an exploded perspective view of the electrode sheet of fig. 1.
Fig. 3 is an exploded perspective view of the electrical functional components of the electrode sheet of fig. 2.
Figure 4 is a plan view of the high dielectric sheet of the electrical functional assembly of figure 3.
Fig. 5 is a plan view of a flexible circuit board of the electrode pad in fig. 2.
Fig. 6 is a perspective view of the electrode sheet of the second embodiment of the electric field tumor treatment system of the present invention.
Fig. 7 is an exploded perspective view of an electrical functional component of the electrode sheet of fig. 6.
Fig. 8 is a perspective view of the electrode sheet of the tumor electric field treatment system according to the third embodiment of the present invention.
Fig. 9 is a perspective view of the flexible circuit board and the lead of the electrode pad in fig. 8.
Description of reference numerals:
Detailed Description
Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, like numbers in different drawings represent the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present invention. Rather, they are merely examples of devices, systems, apparatus, and methods consistent with certain aspects of the invention.
The tumor electric field treatment system of the present invention comprises an electric field generator (not shown) and electrode sheets 100, 100', 100 ″ connected to the electric field generator (not shown). The electrode pieces 100, 100' are attached to the body surface of a patient, and a therapeutic electric field generated by an electric field generator (not shown) is applied to the human body. The electrode sheet 100 of the tumor electric field treatment system of the invention is applied to the body, such as the chest, the abdomen, etc., for tumor treatment.
Fig. 1 to 5 show an electrode sheet 100 according to a first embodiment of the present invention, the electrode sheet 100 can be applied to the body surface of a patient corresponding to a tumor region of a trunk to perform an electric field therapy on the tumor region, and includes a flexible backing 2, an electrical functional component 1 adhered to the backing 2, a support member 3 adhered to the backing 2, an adhesive member 4 adhered to the support member 3, and a lead 5 electrically connected to the electrical functional component 1. The electrode plate 100 of the invention is attached to the corresponding body surface of the tumor part of the patient through the backing 2, and applies an alternating electric field to the tumor part of the patient through the electric functional component 1 to interfere or prevent the mitosis of the tumor cells of the patient, thereby realizing the purpose of treating the tumor.
Referring to fig. 3, the electrical function assembly 1 includes a flexible circuit board 11, a plurality of insulating plates 12 and a plurality of high dielectric sheets 13 respectively disposed on opposite sides of the flexible circuit board 11, and a plurality of temperature sensors 14 fixed on the flexible circuit board 11. The temperature sensor 14 is located on the same side of the flexible circuit board 11 as the high dielectric sheet 13. The plurality of high dielectric sheets 13 are arranged on one side of the flexible circuit board 11 close to the body surface of the patient, and the plurality of insulating plates 12 are arranged on one side of the flexible circuit board 11 far away from the body surface of the patient. The electric functional assembly 1 is respectively adhered to the back lining 2 through the insulating plate 12 and the corresponding part of the flexible circuit board 11 and is closely attached to the back lining 2. The electrode sheet 100 applies an alternating electric signal generated by an electric field generator (not shown) to a tumor site of a patient through a plurality of high dielectric sheets 13 provided on a flexible circuit board 11, thereby performing electric field treatment on the tumor site of the patient.
The flexible circuit board 11 includes a plurality of main body portions 111 arranged in an array, a plurality of connecting portions 112 located between adjacent main body portions 111, and a wiring portion 113 electrically connected to the wires 5. The wire connecting portion 113 may be extended laterally from the connecting portion 112, or may be extended laterally from the main body portion 111, which is free at one end. The plurality of high dielectric sheets 13 are provided in one-to-one correspondence with the plurality of body portions 111, respectively. The high dielectric sheets 13 are welded to the respective body portions 111. The body 111 is provided at the end of the connecting portion 112. The main body 111 is extended from the end of the connecting part 112. Each main body portion 111 is connected to at least two main body portions 111 adjacent thereto through a connecting portion 112. The main body 111 is provided in a substantially circular sheet shape. Alternatively, the main body 111 may be formed in a strip or belt-like configuration and integrally formed with the connecting portion 112. The side of the main body 111 facing the high dielectric sheet 13 is provided with a conductive pad 114 for soldering with the high dielectric sheet 13 by solder (not shown) to assemble the high dielectric sheet 13 on the main body 111 of the flexible circuit board 11. The center of the conductive pad 114 coincides with the center of the body portion 111. Each conductive pad 114 has 4 conductive cores 115 protruding or exposed from the main body 111. The conductive core 115 is disposed in a central symmetrical manner, so that the position of the high dielectric sheet 13 can be effectively prevented from being shifted due to stacking of solder (not shown) during the soldering process. The 4 conductive cores 115 are arranged at intervals, so that the using amount of copper foil for manufacturing the conductive cores 115 can be reduced, and the material cost is reduced; meanwhile, the amount of solder (not shown) used for welding the conductive core 115 and the high dielectric sheet 13 can be saved, thereby further reducing the material cost.
The 4 conductive cores 115 of the same conductive disc 114 are all in a petal configuration. Each of the conductive cores 115 includes an inner arc (not numbered) and an outer arc (not numbered) that are connected end to end. The inner arc (not numbered) and the outer arc (not numbered) of the conductive core 115 are arranged in an axisymmetric manner. The inner arcs (not numbered) of the 4 conductive cores 115 of the same conductive pad 114 are all recessed toward the center of the conductive pad 114. The outer arcs (not numbered) of the 4 conductive cores 115 of the same conductive pad 114 all project away from the center of the conductive pad 114. The 4 conductive cores 115 forming the conductive disc 114 are arranged in a centrosymmetric manner and in an axisymmetric manner, and each conductive core 115 is also arranged in an axisymmetric manner, so that when the 4 conductive cores 115 of the conductive disc 114 of the main body portion 111 are welded with the high dielectric sheet 13, the stress balance of each welding point is ensured, the overall welding balance of the high dielectric sheet 13 is ensured, the welding quality is improved, and the situation that the welding part on the side with a larger interval between the high dielectric sheet 13 and the main body portion 111 is weak in strength and easy to break due to the fact that the welding stress is unbalanced and the high dielectric sheet 13 tilts is avoided; meanwhile, the fitting degree of the electrode plate 100 can be prevented from being affected. The outer arcs (not numbered) of the 4 conductive cores 115 of the same conductive disk 114 are located substantially on the same circumference.
The number of the main body parts 111 is at least 10, and the main body parts are distributed in an array area which is at least arranged in three rows and four columns. The number of the high dielectric sheets 13 is at least 10, and the arrangement mode of the high dielectric sheets is consistent with that of the main body part 111, so that the coverage area of the electrode sheet 100 can be increased, the electric field intensity applied to a tumor part for tumor electric field treatment is enhanced, the range of the alternating electric field covering the tumor part is enlarged, and the treatment effect is improved. Preferably, the number of the main body 111 and the number of the high dielectric sheets 13 are 13, and both of them may be distributed in a matrix area with five rows and three columns, or may be distributed in a matrix area with five rows and five columns. From the line arrangement perspective, each of the first and last lines is provided with 2 main body portions 111, and each of the middle three lines is provided with 3 main body portions 111. In the present embodiment, the main body portions 111 are distributed in an array region arranged in five rows and five columns, and from the column arrangement perspective, 3 main body portions 111 are disposed in each of the first column, the third column, and the fifth column, and 2 main body portions 111 are disposed in each of the second column and the fourth column. Specifically, the 2 main body portions 111 in the first row are respectively located in the second column and the fourth column, the 3 main body portions 111 in each row in the middle three rows are respectively located in the first column, the third column and the fifth column, and the 2 main body portions 111 in the last row are respectively located in the second column and the fourth column. Two adjacent main body portions 111 in each row are arranged in a spaced row. The adjacent two main body portions 111 in the same row have the same pitch. The distance between two adjacent main body portions 111 in the same column is equal. The two main bodies 111 located in the last row are separated from each other, and a space C is formed between the two main bodies 111. The wire connecting portion 113 is extended laterally from the main body portion 111 located in the fourth row and the third column. The wire portion 113 passes through the space C formed between the two last-row main body portions 111.
The connecting portion 112 connects two adjacent main body portions 111, and the conductive pad 114 is disposed on the main body portion 111 at the end of the connecting portion 112. The connecting portion 112 includes a first connecting portion 112A connecting two adjacent main body portions 111 located in the same row and spaced column, a second connecting portion 112B connecting two adjacent main body portions 111 located in the same column and adjacent row, and a third connecting portion 112C connecting two main body portions 111 located in adjacent row and adjacent column and distributed diagonally. The first connecting portions 112A are located between two adjacent main body portions 111 in every row and every column, and have the same length. The second connecting portion 112B is located between two adjacent main body portions 111 in each of the first, third, and fifth rows, and has the same length. The length of the third connection portion 112C is greater than half the length of the first connection portion 112A. The length of the third connection portion 112C is greater than the length of the second connection portion 112B. The first connection portion 112A and the second connection portion 112B are both disposed in a substantially "straight" shape. The third connecting portion 112C is substantially L-shaped or inclined. The number of the third connecting portions 112C is 8, and the third connecting portions are respectively located between the two main body portions 111 in the first second row and the first second row, between the two main body portions 111 in the first second row and the second third row, between the two main body portions 111 in the second third row and the first fourth row, between the two main body portions 111 in the first fourth row and the second fifth row, between the two main body portions 111 in the last second row and the first fourth row, between the two main body portions 111 in the last second row and the fourth third row, between the two main body portions 111 in the fourth row and the last fourth row, and between the two main body portions 111 in the last fourth row and the fourth row. Preferably, the length of the first connection portion 112A is greater than the diameter of the main body portion 111. The length of the second connection portion 112B is smaller than the diameter of the body portion 111. The first connecting portion 112A and the second connecting portion 112B are disposed vertically, the third connecting portion 112C and the first connecting portion 112A adjacent thereto are disposed in an acute angle shape, and the second connecting portion 112B and the third connecting portion 112C adjacent thereto are also disposed in an acute angle shape.
The main body portion 111 may be divided into a peripheral main body portion 111A located at the periphery of the array and a central main body portion 111B surrounded by the peripheral main body portion 111A and located at an inner layer of the array according to the distribution position of the main body portion in the array. Specifically, the number of the peripheral main body portions 111A is 10, and the number of the central main body portions 111B is 3 and is located in the same column. The peripheral main body portion 111A and the central main body portion 111B are connected to each other two by two via connecting portions 112. The two adjacent peripheral main body portions 111A are electrically connected through either a first connection portion 112A, a second connection portion 112B, or a third connection portion 112C. Specifically, the two adjacent peripheral main body portions 111A in the same column are connected by a second connecting portion 112B, the two adjacent peripheral main body portions 111A in the same row are connected by a first connecting portion 112A, and the two adjacent peripheral main body portions 111A in the adjacent rows and columns and arranged diagonally are connected by a third connecting portion 112C. The peripheral main body portions 111A and the first connecting portion 112A, the second connecting portion 112B, and the third connecting portion 112C located between two adjacent peripheral main body portions 111A are arranged in an approximately octagonal shape with one end open. The peripheral main body 111A is disposed in an axisymmetric manner, and the symmetry axis thereof coincides with the straight line on which the 3 central main bodies 111B are located.
The central body 111B is 3 bodies 111 located in the third row. Each of the central main body portions 111B and the peripheral main body portions 111A adjacent thereto are connected with each other by a first connecting portion 112A or a third connecting portion 112C. The two adjacent central main body portions 111B are electrically connected by a second connecting portion 112B. Specifically, the central main body portion 111B and the adjacent peripheral main body portions 111A located in the same row are electrically connected through the first connecting portion 112A, and the central main body portion 111B and the adjacent peripheral main body portions 111A located in the adjacent row and arranged diagonally are electrically connected through the third connecting portion 112C, so that the central main body portion 111B and the adjacent peripheral main body portions 111A are connected through at least two connecting portions 112, and the positions between the peripheral main body portions 111A and the central main body portions 111B are ensured to be relatively fixed, the connection is stable, and the high dielectric sheets 13 are conveniently soldered on the flexible circuit board 11. That is, the central body portion 111B located in the third row is connected to the peripheral body portion 111A located in the same row thereof only by the first connecting portion 112A, and is disposed in a disconnected state between the adjacent peripheral body portions 111A located in adjacent rows and adjacent columns and arranged diagonally. Each of the remaining two central main body portions 111B is connected not only to the peripheral main body portions 111A located in adjacent rows and columns and diagonally arranged thereto through the third connecting portion 112C, but also to the peripheral main body portions 111A located in the same row therewith through the first connecting portion 112A.
The wire connecting portion 113 is extended laterally from one of the two main body portions 111 located at the end of the 3 main body portions 111 located at the third row. Specifically, the wire connecting portion 113 is laterally extended from the main body 111 of the fourth row and the third column. The wire connecting portion 113 is extended from the central main body portion 111B located at the end portion toward a region distant from the array of the main body portions 111. The wire connecting portion 113 is located between the two third connecting portions 112C, and connects the central body portion 111B located at the end portion simultaneously with the two third connecting portions 112C. The wire connecting portion 113 and two third connecting portions 112C, which are connected to the same central body portion 111B in common, are provided substantially in an arrow shape. The wire connecting portion 113 extends between two peripheral main body portions 111A arranged in the same row and in a disconnected state. The wire connecting portion 113 is disposed substantially perpendicular to the first connecting portion 112A. The wire connecting portion 113 is provided substantially in parallel with the second connecting portion 112B. The wire connecting portion 113 is substantially in a line shape. The angle between the wire connecting portion 113 and the third connecting portion 112C, which are simultaneously connected to the same main body portion 111, is an acute angle. In other embodiments, the wire connecting portion 113 may also be laterally extended from the main body portion 111 located in the second row and the third column or the central main body portion 111B; the two main bodies 111 positioned in the leading row are separated from each other, and the wire connecting portion 113 passes through the space between the two main bodies 111. In other embodiments, the wire connecting portion 113 may also be laterally extended from a second connecting portion 112B located between two adjacent central main body portions 111B, and the wire connecting portion 113 is perpendicular to the second connecting portion 112B; the wire connecting portion 113 is provided substantially in a T-shape with the second connecting portion 112B extending the wire connecting portion 113.
The insulating plate 12 is arranged in a substantially circular sheet shape. The insulating plate 12 is made of an insulating material, and is adhered to a side surface of the main body 111 of the flexible circuit board 11 away from the body surface of the patient by a sealant (not shown), so that the strength of the flexible circuit board 11 is enhanced, and a flat welding plane can be provided for the welding operation between the conductive plate 114 and the high dielectric sheet 13, thereby improving the product yield. The insulating plate 12 can prevent moisture in the air on the side of the electrical functional assembly 1 away from the body surface of the patient from entering the electrical functional assembly 1, so as to prevent the moisture from contacting with a solder (not shown) between the high dielectric sheet 13 and the main body portion 111 to affect the electrical connection between the main body portion 111 and the high dielectric sheet 13. The insulating plates 12 are disposed in one-to-one correspondence with the main body 111, and the arrangement of the insulating plates is consistent with that of the main body 111.
The high dielectric sheet 13 is arranged in a circular sheet shape. The high dielectric sheet 13 is made of a high dielectric constant material, and has a characteristic of blocking direct current and alternating current, so that the safety of a human body can be ensured. The high dielectric sheet 13 has a dielectric constant of at least more than 1000. The high dielectric sheet 13 has a ring-shaped metal layer 131 attached to the side facing the main body 111, and is soldered to the conductive pad 114 on the main body 111 by solder (not shown). A gap (not shown) formed between the high dielectric sheet 13 and the main body 111 by welding is filled with a sealant (not shown) to protect a solder (not shown) between the high dielectric sheet 13 and the main body 111, so as to prevent the welding part from being broken due to the influence of an external force on the high dielectric sheet 13, and further prevent an alternating electric field from being applied to a tumor part of a patient through the high dielectric sheet 13; meanwhile, it is avoided that moisture in the air enters the gap (not shown) to erode solder (not shown) between the high dielectric sheet 13 and the main body 111, thereby affecting the electrical connection between the high dielectric sheet 13 and the main body 111. The outer ring of the metal layer 131 and the outer edge of the high dielectric sheet 13 are spaced from each other, so that solder (not shown) between the metal layer 131 of the high dielectric sheet 13 and the main body 111 is prevented from overflowing the main body 111 when being melted by heat, and direct current which is not blocked by the high dielectric sheet 13 is prevented from directly acting on the body surface of the patient when the electrode sheet 100 is applied to the body surface corresponding to the tumor part of the patient. The high dielectric sheet 13 has an opening 132 provided therethrough for receiving the temperature sensor 14. The edge of the opening 132 of the high dielectric sheet 13 is spaced from the inner ring of the metal layer 131 of the high dielectric sheet 13, so that it is possible to prevent the solder (not shown) between the metal layer 131 of the high dielectric sheet 13 and the main body 111 from diffusing in the direction of the opening 132 of the high dielectric sheet 13 when melted by heat and causing a short circuit of the temperature sensor 14. The main body 111, the insulating plate 12, and the high dielectric sheet 13 are disposed in one-to-one correspondence, and centers of the three are located on the same straight line. The arrangement of the insulating plates 12 and the high dielectric plates 13 is consistent with that of the main body 111, and the insulating plates and the high dielectric plates are distributed in an array area arranged in five rows and five columns.
The main body 111 of the flexible circuit board 11, the insulating plate 12 disposed on the side of the main body 111 of the flexible circuit board 11 away from the surface of the patient, and the high dielectric sheet 13 disposed on the side of the main body 111 of the flexible circuit board 11 facing the epidermis of the patient together constitute the electrode unit 10 of the electrical functional assembly 1. The arrangement of the electrode units 10 of the electrical functional assembly 1 is identical to that of the main body portion 111 of the flexible circuit board 11. The connecting portion 112 is located between two adjacent electrode units 10.
The temperature sensor 14 is fixed to the body portion 111 for monitoring the temperature of the adhesive member 4, thereby monitoring the temperature of the skin of the human body applied with the adhesive member 4. When the temperature monitored by the temperature sensor 14 exceeds the upper limit of the human body safety temperature, the electric field generator (not shown) can timely reduce or close the alternating current transmitted to the electrode plate 100, so as to avoid low-temperature scald of the human body. The temperature sensor 14 is soldered to the body portion 111 and then sealed with a sealant (not shown) to prevent moisture from attacking the temperature sensor 14 and causing the temperature sensor 14 to fail. The temperature sensor 14 is disposed on the peripheral main body 111 among the plurality of main bodies 111 arranged in an array. That is, the temperature sensor 14 is provided on the peripheral body portion 111A.
One end of the lead 5 is welded to the wiring portion 113 of the electrical functional assembly 1, and the other end is provided with a plug (not numbered) electrically connected to an electric field generator (not shown). The plug (not numbered) of the lead 5 can be directly inserted into the electric field generator (not shown) or inserted into an adapter (not shown) of the tumor electric field treatment system, and then the electric connection between the lead 5 and the electric field generator (not shown) is realized by electrically connecting the adapter (not shown) and the electric field generator (not shown). The junction cladding of wiring portion 113 has heat shrinkage bush 51 on wire 5 and the flexible circuit board 11 for the junction of wiring portion 113 is sealed, insulation protection on wire 5 and the flexible circuit board 11, and the improvement intensity supports, avoids wire 5 and electric function component 1 junction to break off, simultaneously can also dustproof and waterproof.
The support 3 is a sheet-like arrangement. The support 3 is provided in plurality. The support 3 is adhered to the backing 2 in a manner surrounding the electrode units 10 arranged in rows. The plurality of supports 3 are arranged at intervals. The support 3 has a plurality of through-holes 31 provided corresponding to the respective electrode units 10. The plurality of through holes 31 are arranged at intervals. The thickness of the support member 3 is substantially consistent with that of the electrode unit 10, the plane where the top end of the support member 3 is located and the surface of the electrode unit 10 facing the patient body surface are at the same vertical height, that is, the surface of the support member 3 close to the patient body surface is flush with the surface of the high dielectric sheet 13 close to the patient body surface, so that the pasting member 4 can be flatly covered on the support member 3 and the electrode unit 10, and the comfort of pasting the electrode sheet 100 is improved. The supporting member 3 can be made of Polyethylene (PE) material, PET material, heat conductive silica gel sheet, or soft, chemically stable, light, non-deformable and non-toxic insulating material compounded by polyurethane, polyethylene, dispersant, flame retardant, carbon fiber, etc. Preferably, the support 3 is a flexible foam.
The adhesive member 4 is arranged in a sheet shape, one side of which is attached to the support member 3 and the high dielectric sheet 13, and the other side is attached to the body surface of the patient. The adhesive member 4 is a conductive hydrogel which acts as a conductive medium to conduct alternating current through the high dielectric sheet 13 to the tumor site of the patient. The number of the adhesive members 4 is the same as the number of the supporting members 3. The size of the adhesive member 4 is substantially the same as the size of the support member 3.
As shown in fig. 2, the backing 2 is in the form of a sheet, which is made mainly of a material compatible with flexibility, breathability, insulation, sterilization. The back lining 2 is provided with a plurality of air holes (not shown) which are arranged in a penetrating way, so that when the back lining 2 is pasted on the surface of a patient, the hair follicles and sweat glands of the skin of the patient covered by the back lining 2 can freely breathe, and the skin inflammation caused by the damage to the superficial layer of the skin of the patient due to the blockage of the sweat glands and hair follicles of the surface of the patient covered by the back lining 2 is avoided. The backing 2 is a mesh fabric. Specifically, the backing 2 is a mesh nonwoven fabric. The side of the backing 2 facing the patient's body surface is also coated with a compatible adhesive (not shown) for adhering the backing 2 to the patient's body surface in the desired area.
Fig. 6 to 7 show an electrode sheet 100' according to a second embodiment of the present invention, which is also applied to the body surface of the trunk of a patient for performing the tumor electric field treatment on the tumor site located on the trunk, and includes a flexible backing 2', an electrical functional component 1' adhered to the backing 2', a support 3' adhered to the backing 2', an adhesive member (not shown) adhered to the support 3', and a lead 5' electrically connected to the electrical functional component 1 '. The electrical functional assembly 1 'also includes a flexible circuit board 11', a plurality of insulating plates 12 'and a plurality of high dielectric sheets 13' respectively disposed on opposite sides of the flexible circuit board, and a plurality of temperature sensors 14 'fixed on the flexible circuit board 11'. The main body portions 111', the high dielectric sheets 13' and the insulating plates 12' are disposed in one-to-one correspondence, and constitute the electrode units 10' of the electrical functional assembly 1 '. The main body portions 111 'are also arranged in five rows and five columns, and the positions of the main body portions 111' distributed in the array region of the five rows and five columns are consistent with the arrangement of the main body portions 111 of the first embodiment.
The electrode sheet 100 'in the present embodiment is different from the electrode sheet 100' described in the first embodiment in that: the peripheral main body portions 111A ' of the flexible circuit board 11' of the electrical functional assembly 1' of the electrode sheet 100' are connected two by the connecting portions 112', and the central main body portions 111B ' are connected only with the peripheral main body portions 111A ' adjacent to each other in the same row. Specifically, the two adjacent peripheral main body portions 111A 'are connected two by two either by the first connection portion 112A', the second connection portion 112B ', or the third connection portion 112C'. The peripheral body portions 111A ' and the first, second, and third connecting portions 112A ', 112B ', 112C ' between two adjacent peripheral body portions 111A ' have a substantially racetrack-like configuration. The central main body portion 111B ' and the peripheral main body portions 111A ' located in the same row are connected by a first connection portion 112A '. The central main body portion 111B 'is disposed in a disconnected manner with the peripheral main body portions 111A' located in adjacent rows and columns and arranged diagonally. Two adjacent central main body portions 111B 'of the 3 central main body portions 111B' are provided in a disconnected shape. The second connecting portion 112 'is not provided between the two adjacent central body portions 111B' provided in the disconnected state. The third connecting portion 112C' is disposed in an arc shape. The number of the third connecting portions 112C ' is set to 4, and the three third connecting portions are respectively located between the two peripheral main body portions 111A ' of the first row second column and the first column second row, between the two peripheral main body portions 111A ' of the first row fourth column and the second row fifth column, between the two peripheral main body portions 111A ' of the last row second column and the first column fourth row, and between the two peripheral main body portions 111A ' of the last row fourth column and the fourth row fifth column. The third connecting portion 112C 'and the adjacent first connecting portion 112A' are both disposed substantially in an obtuse angle or an acute angle. The third connecting portion 112C 'and the adjacent second connecting portion 112B' are both disposed substantially at an obtuse angle. The peripheral main body portion 111A 'has the same diameter as the central main body portion 111B', and the length of the second connecting portion 112B 'is slightly greater than the diameter of the peripheral main body portion 111A'.
The wire connecting portion 113 'is laterally extended from a second connecting portion 112B'. Specifically, the wire connecting portion 113' is laterally extended by a second connecting portion 112B ' located between two adjacent central body portions 111B '. The wire connecting portion 113' is substantially T-shaped with the second connecting portion 112B ' of the extended wire connecting portion 113 '. The wire connecting portion 113 'is perpendicular to the second connecting portion 112B'. The wire connecting portion 113 'is substantially parallel to the first connecting portion 112A'.
The flexible circuit board 11 'is also provided with a reinforcing part 116' which is arranged opposite to the wiring part 113 'and can provide traction for the wiring part 113', so that the electrode plate 100 'is prevented from being affected by uneven stress when the electrode plate 100' is pasted on the body surface of the tumor part of the patient. Specifically, the reinforcing portion 116' is extended from the second connecting portion 112B ' of the laterally extended wire connecting portion 113 '. The reinforcing portion 116 'and the wire connecting portion 113' are located on opposite sides of the second connecting portion 112B 'connected to the wire connecting portion 113', respectively. The reinforcing portion 116 'has one end connected to the second connecting portion 112B' connected to the wire connecting portion 113 'and the other end connected to the second connecting portion 112B' adjacent to the second connecting portion 112B 'and located between the two adjacent peripheral main body portions 111A'. The reinforcing portion 116 'is bridged between two adjacent and parallel second connecting portions 112B'. The reinforcing portion 116', the wire connecting portion 113', and the second connecting portion 112B 'connected to the wire connecting portion 113' are arranged substantially in a cross shape.
The backing 2 'is provided with a threading hole 21' corresponding to the wiring portion 113 'of the flexible circuit board 11'. One end of the lead wire 5' passes through the threading hole 21' and is electrically connected to the wiring portion 113 '. The leads 5 'extend into the flexible circuit board 11' from one side of the back lining 2 'to be connected with the wiring part 113', so that the problem that the comfort is reduced when the electrode plate 100 'is applied due to the fact that a large number of leads 5' are directly pressed on the skin of a patient is avoided.
Fig. 8 to 9 show an electrode sheet 100 "according to a third embodiment of the present invention, which is also applied to the body surface of a patient's trunk for tumor electric field therapy of a tumor region located on the trunk, and includes a flexible backing 2", an electrical functional component 1 "adhered to the backing 2", a support 3 "adhered to the backing 2", an adhesive member (not shown) adhered to the support 3 ", and a lead 5" electrically connected to the electrical functional component 1 ".
The electrode sheet 100 "in the present embodiment is different from the electrode sheet 100" described in the first embodiment in that: the high dielectric sheets 13 "of the electrical functional components 1 of the electrode sheet 100" and the main body portions 111 "on the flexible circuit board 11, which are arranged in one-to-one correspondence with the high dielectric sheets 13", are all distributed in an array region of five rows and three columns. From the column arrangement perspective, the first and third columns each have 5 body portions 111 ", and the second column has 3 body portions 111". Specifically, the 2 main body portions 111 ″ located in the top row are located in the first column and the third column, respectively. The 2 body parts 111 "in the last row are also located in the first and third columns, respectively. The 3 body portions 111 "of each row of the middle three rows are located in the first column, the second column, and the third column, respectively. The main body parts 111 ″ in the first and last rows are arranged in a spaced array, and the main body parts 111 ″ in the first and last rows are arranged in a disconnected array. The distance between two adjacent main bodies 111 ″ in the same row is different. The two adjacent main body portions 111 ″ in the same column have the same pitch. The 13 main body parts 111 "are arranged in an axisymmetric shape, one symmetry axis of the axisymmetric shape coincides with a straight line where the 3 main body parts 111" located in the third row are located, and the other symmetry axis of the axisymmetric shape coincides with a straight line where the 3 main body parts 111 "located in the second row are located. The 13 main body parts 111 ″ are also arranged in a centrosymmetric manner, and the symmetric center thereof coincides with the center of the main body part 111 ″ located in the third row and the third column. The electrode unit 10 ″ is arranged in the same manner as the main body 111 ″ and is located in the array region of five rows and three columns.
The main body portion 111 "may be divided into 12 peripheral main body portions 111A" located at the periphery of the array and 1 central main body portion 111B "surrounded by the peripheral main body portions 111A" and located at an inner layer of the array according to the distribution position of the main body portions 111 "in the array. Specifically, the 1 central body portion 111B ″ is located at the body portion 111 ″ at the third row and second column position. The 12 peripheral body portions 111A ″ are all the body portions 111 ″ except the body portion 111 ″ located in the third row and the second column. The peripheral body portions 111A "are connected either by the second connection portion 112B" or by the third connection portion 112C ". The two adjacent peripheral body portions 111A ″ in the same column are connected by the second connection portion 112B ″. The two peripheral main body portions 111A ″ located in adjacent rows and adjacent columns and arranged diagonally are connected by a third connecting portion 112C ″. The two adjacent peripheral main body portions 111A ″ arranged in the same row and at intervals are arranged in a disconnected state. The peripheral main body portion 111A "and the central main body portion 111B" are connected by either a first connection portion 112A "or a second connection portion 112B". Specifically, the peripheral main body portions 111A ″ and the central main body portions 111B ″ adjacent to each other in the same row are connected by the first connection portion 112A ″. The peripheral main body portion 111A ″ and the central main body portion 111B ″ adjacent to each other in the same column are connected to each other by a second connection portion 112B ″. The first connecting portion 112A ″ is located between the two main body portions 111 ″ in the adjacent columns and rows, and has the same length. The second connecting portion 112B "is located between the two main body portions 111" in adjacent rows in the same column, and has the same length. The length of the third connection portion 112C "is greater than the length of the first connection portion 112A". The number of the third connecting portions 112C "is 4, and the third connecting portions are respectively located between the two peripheral main body portions 111A" of the first row and the second row, between the two peripheral main body portions 111A "of the second row and the first row and the third row, between the two peripheral main body portions 111A" of the fifth row and the fourth row and the second row, and between the two peripheral main body portions 111A "of the fourth row and the third row. The peripheral main body portions 111A ″ are disposed in an axisymmetric manner, one of the axes of symmetry coincides with the extending direction of the row in which the central main body portion 111B ″ is disposed, and the other axis of symmetry coincides with the extending direction of the column in which the central main body portion 111B ″ is disposed. The wiring portion 113 "is extended by the peripheral main body portion 111A" located in the fourth row and the second column. The wire connecting portion 113 "is located between two adjacent third connecting portions 112C" to which the same peripheral main body portion 111A "is commonly connected.
The backing 2 "is provided with threading holes 21" corresponding to the wiring portions 113 "of the flexible circuit board 11". One end of the lead 5 "passes through the threading hole 21" and is electrically connected to the wiring portion 113 ". The lead 5 'extends into the flexible circuit board 11' from one side of the back lining 2 'to be connected with the wiring part 113', so that the problem that the comfort is reduced when the electrode plate 100 'is applied due to the fact that a large number of leads 5' are directly pressed on the skin of a patient is avoided.
The electrode plates 100, 100 'of the invention are inserted with an electric field generator (not shown) through the plugs (not numbered) of the leads 5, 5' of the electrode plates, and are electrically connected with the electrode units 10, 10 'through one ends of the leads 5, 5' to realize that alternating electric signals generated by the electric field generator (not shown) are transmitted to the electrode units 10, 10', and further realize the purpose of applying an alternating electric field to the tumor part of a patient to treat tumors through the electrode units 10, 10'. The electrode plates 100, 100 'and 100' of the invention apply alternating electric field to the tumor part of the patient for tumor treatment through at least 10 electrode units 10, 10 'and 10' distributed in at least four rows and three columns of array areas, thus increasing the area of the electrode plates 100, 100 'and 100' covering the tumor part, enhancing the electric field intensity for tumor electric field treatment and further ensuring the tumor electric field treatment effect. The electrode pieces 100, 100 'and 100' of the tumor electric field treatment system are suitable for being pasted on the trunk of a patient for use. For example, when the electrode sheet 100, 100', 100 ″ is applied to the front side and the rear side of the waist of a patient, one electrode sheet 100, 100', 100 ″ is applied to each of the front side and the rear side of the waist of the patient, and one electrode sheet 100, 100', 100 ″ is applied to each of the two sides of the waist of the patient.
The present invention is not limited to the above preferred embodiments, but rather should be construed as broadly within the spirit and scope of the invention as defined in the appended claims.
Claims (17)
1. The electrode slice is used for carrying out electric field treatment on a trunk tumor part of a patient during electric field treatment of tumors and comprises a plurality of electrode units which are arranged in an array mode, a plurality of connecting parts for connecting two adjacent electrode units and wires which are electrically connected with the electrode units.
2. The electrode sheet according to claim 1, wherein at least two adjacent electrode units among the plurality of electrode units are arranged in a disconnected state and are formed with a space between the two adjacent electrode units arranged in the disconnected state.
3. The electrode sheet according to claim 2, further comprising a wire connecting portion electrically connected to the connecting portion or the electrode unit, the wire connecting portion passing through the space and being welded to the wire.
4. The electrode sheet of claim 3, wherein two adjacent electrode units arranged in a row are arranged in a spaced row, and at least two adjacent electrode units in a same row in the electrode units arranged in a row are arranged in a spaced row.
5. The electrode sheet according to claim 4, wherein the spacing between two adjacent electrode units arranged in a row is the same, and the spacing between two adjacent electrode units arranged in a column is different.
6. The electrode sheet according to claim 4, wherein a plurality of connecting portions between two adjacent electrode units in the same row have the same length, and a plurality of connecting portions between two adjacent electrode units in the same column have different lengths.
7. The electrode sheet of claim 4, wherein the number of the plurality of electrode units is 13, and the electrode units are distributed in an area arranged in five rows and five columns.
8. The electrode sheet of claim 3, wherein at least two adjacent electrode units of the plurality of electrode units arranged in a row are arranged in a spaced row, and the plurality of electrode units arranged in a row are arranged in an adjacent row.
9. The electrode sheet according to claim 8, wherein the spacing between two adjacent electrode units arranged in a row is different, and the spacing between two adjacent electrode units arranged in a column is the same.
10. The electrode sheet according to claim 8, wherein a plurality of connecting portions between two adjacent electrode units in the same row have different lengths, and a plurality of connecting portions between two adjacent electrode units in the same column have the same length.
11. The electrode sheet of claim 7, wherein the plurality of electrode units is 13, and is distributed in an area arranged in three rows and five columns.
12. The electrode sheet according to claim 3, wherein the connection parts include a first connection part connecting adjacent two electrode units located in the same row and a second connection part connecting adjacent two electrode units located in the same column.
13. The electrode sheet according to claim 12, wherein the connecting portion further comprises a third connecting portion connecting two adjacent electrode units located in adjacent rows and adjacent columns and arranged diagonally.
14. The electrode sheet of claim 13, wherein the third connection portion has a length greater than a length of the first connection portion.
15. The electrode sheet of claim 13, wherein the length of the third connection portion is greater than half the length of the first connection portion.
16. The electrode sheet according to claim 13, wherein the length of the third connection portion is greater than the length of the second connection portion.
17. An electric field tumor treatment system, comprising an electric field generator and an electrode pad according to any one of claims 1 to 16 electrically connected to the electric field generator.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111578521.1A CN114272513A (en) | 2021-12-22 | 2021-12-22 | Tumor electric field treatment system and electrode plate thereof |
| PCT/CN2022/134677 WO2023051845A1 (en) | 2021-09-28 | 2022-11-28 | Tumor electric field treatment system |
| PCT/CN2022/134717 WO2023051846A1 (en) | 2021-09-28 | 2022-11-28 | Tumor electric field treatment system |
| PCT/CN2022/137451 WO2023116448A1 (en) | 2021-12-22 | 2022-12-08 | Insulation electrode for electric field-based tumor treatment, and manufacturing method therefor |
| PCT/CN2022/138105 WO2023116473A1 (en) | 2021-12-22 | 2022-12-09 | Electrode slice air tightness test device, system and method |
| PCT/CN2022/140141 WO2023116644A1 (en) | 2021-12-22 | 2022-12-19 | Tumor treating fields system and alternating current electrical signal application method thereof |
| PCT/CN2022/140432 WO2023116714A1 (en) | 2021-12-22 | 2022-12-20 | Method for manufacturing electrode patch for tumor-treating fields |
| PCT/CN2022/140412 WO2023116708A1 (en) | 2021-12-22 | 2022-12-20 | Electrode array detection device, system and method for tumor electric field therapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111578521.1A CN114272513A (en) | 2021-12-22 | 2021-12-22 | Tumor electric field treatment system and electrode plate thereof |
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| Publication Number | Publication Date |
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| CN114272513A true CN114272513A (en) | 2022-04-05 |
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| CN202111578521.1A Pending CN114272513A (en) | 2021-09-28 | 2021-12-22 | Tumor electric field treatment system and electrode plate thereof |
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| WO2023116448A1 (en) * | 2021-12-22 | 2023-06-29 | 江苏海莱新创医疗科技有限公司 | Insulation electrode for electric field-based tumor treatment, and manufacturing method therefor |
| WO2023116714A1 (en) * | 2021-12-22 | 2023-06-29 | 江苏海莱新创医疗科技有限公司 | Method for manufacturing electrode patch for tumor-treating fields |
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