CN219039092U - Reagent supply device and sample analyzer - Google Patents

Abstract

The application provides a reagent supply device and sample analyzer, the reagent supply device includes: a reagent storage unit including a reagent storage container; the liquid adding unit comprises a liquid adding pipe and a first power element, wherein the liquid adding pipe is communicated with the reagent storage container; the liquid discharge unit comprises an exhaust pipe, a second power element and a liquid discharge pipe, wherein the liquid discharge pipe is communicated with the reagent storage container, the second power element is communicated with the exhaust pipe so as to provide positive pressure for the reagent storage container through the exhaust pipe, the liquid discharge pipe is communicated with the reagent storage container, so that reagents in the reagent storage container are discharged from the liquid discharge pipe under the action of the positive pressure, negative air pressure is not required to be formed, the injection and the discharge of the reagents in the reagent storage container can be performed simultaneously, the supply of the reagents can be continuously performed, the condition of discontinuous supply can not occur, and the efficiency of the reagent supply is improved.

Description

Reagent supply device and sample analyzer

Technical Field

The application relates to the technical field of medical instruments, in particular to a reagent supply device and a sample analyzer.

Background

In the detection of a sample, it is generally necessary to react a reagent with the sample in a reaction cell and then detect the reacted sample, and therefore, it is necessary to inject the reagent into the reaction cell.

In the prior art, the reagent is injected into the reaction tank in the following general mode: the negative air pressure is formed in the liquid storage tank through the low-pressure pump, so that the reagent in the reagent barrel is injected into the liquid storage tank under the action of the negative air pressure, then the positive air pressure is formed in the liquid storage tank through the high-pressure pump, so that the reagent in the liquid storage tank is discharged to the reaction tank under the action of the positive air pressure.

Disclosure of Invention

The application mainly provides a reagent supply device and a sample analyzer, which can improve the efficiency of reagent supply.

In order to solve the technical problems, one technical scheme adopted by the application is as follows: there is provided a reagent supply device including: a reagent storage unit including a reagent storage container; the liquid adding unit comprises a liquid adding pipe and a first power element, wherein the liquid adding pipe is communicated with the reagent storage container, and the first power element is communicated with the liquid adding pipe so as to extract the reagent through the liquid adding pipe and inject the reagent into the reagent storage container; the liquid draining unit comprises an exhaust pipe, a second power element and a liquid draining pipe, wherein the liquid draining pipe is communicated with the reagent storage container, the second power element is communicated with the exhaust pipe so as to provide positive pressure for the reagent storage container through the exhaust pipe, and the liquid draining pipe is communicated with the reagent storage container so that reagents in the reagent storage container are discharged from the liquid draining pipe under the action of the positive pressure.

In one embodiment, the liquid discharge unit further includes a liquid discharge control member mounted on the liquid discharge pipe to block or communicate the liquid discharge pipe.

In a specific embodiment, the reagent storage unit further comprises a first detector for detecting the amount of reagent in the reagent storage container.

In a specific embodiment, the liquid discharge unit further includes a second detector for detecting a liquid discharge amount or a liquid discharge speed of the liquid discharge pipe.

In a specific embodiment, the reagent supply device further comprises a controller, the controller is electrically connected with the first detector or the second detector, and the first power element is electrically connected with the controller, so that the controller sends a corresponding control signal to the first power element according to the detection signal of the first detector or the second detector.

In a specific embodiment, the number of the reagent storage units, the liquid adding units and the liquid draining units is multiple, and the reagent supply device further comprises liquid inlet pipes, wherein the liquid inlet pipes are respectively communicated with the liquid adding pipes, so that the multiple first power elements respectively extract the reagent to the multiple liquid adding pipes through the liquid inlet pipes.

In a specific embodiment, the reagent supply device further includes a liquid pumping unit, the liquid pumping unit includes a third power element and a liquid pumping tube, the liquid pumping tube is communicated with the liquid inlet tube, and the third power element is communicated with the liquid pumping tube, so that the reagent is pumped to the liquid inlet tube through the liquid pumping tube.

In a specific embodiment, the liquid pumping unit further comprises a waste liquid storage container, the liquid pumping pipe comprises a first pipeline and a second pipeline, the first pipeline is respectively communicated with the liquid inlet pipe and the waste liquid storage container, the second pipeline is respectively communicated with the waste liquid storage container and the third power element, and the third power element is used for providing negative pressure for the waste liquid storage container through the second pipeline so that the reagent is pumped to the liquid inlet pipe under the action of the negative pressure.

In a specific embodiment, the liquid inlet pipe is provided with a first opening and a second opening, the liquid inlet pipe is used for extracting the reagent through the first opening, the second opening is communicated with the first pipeline, and the liquid adding pipe is communicated between the first opening and the second opening.

In order to solve the technical problems, another technical scheme adopted by the application is as follows: the sample analyzer comprises the reagent supply device and the detection device, wherein the detection device is used for detecting a sample reacted with the reagent.

The beneficial effects of this application are: unlike the prior art, the reagent supplying apparatus provided in the embodiment of the present application includes: a reagent storage unit including a reagent storage container; the liquid adding unit comprises a liquid adding pipe and a first power element, wherein the liquid adding pipe is communicated with the reagent storage container, and the first power element is communicated with the liquid adding pipe so as to extract the reagent through the liquid adding pipe and inject the reagent into the reagent storage container; the liquid discharge unit comprises an exhaust pipe, a second power element and a liquid discharge pipe, wherein the liquid discharge pipe is communicated with the reagent storage container, the second power element is communicated with the exhaust pipe so as to provide positive pressure for the reagent storage container through the exhaust pipe, the liquid discharge pipe is communicated with the reagent storage container so that reagents in the reagent storage container are discharged from the liquid discharge pipe under the action of the positive pressure.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the description of the embodiments will be briefly introduced below, it being obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of the principle structure of an embodiment of a reagent supplying apparatus provided in the present application;

FIG. 2 is a schematic diagram of the reagent storage unit of FIG. 1;

FIG. 3 is a schematic diagram of another embodiment of the drain control element of FIG. 1;

FIG. 4 is a schematic diagram of another embodiment of the liquid discharge unit of FIG. 1;

FIG. 5 is a schematic control diagram of the reagent supply device of FIG. 1;

fig. 6 is a schematic diagram of another embodiment of the reagent supplying apparatus provided in the present application.

Detailed Description

The present application is described in further detail below with reference to the drawings and the embodiments. It is specifically noted that the following embodiments are merely for illustrating the present application, but do not limit the scope of the present application. Likewise, the following embodiments are only some, but not all, of the embodiments of the present application, and all other embodiments obtained by one of ordinary skill in the art without inventive effort are within the scope of the present application.

The terms "first," "second," "third," and the like in this application are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second", and "a third" may explicitly or implicitly include at least one such feature. In the description of the present application, the meaning of "plurality" means at least two, such as two, three, etc., unless explicitly specified otherwise. All directional indications (such as up, down, left, right, front, back … …) in this embodiment are merely used to explain the relative positional relationship, movement, etc. between the components in a particular gesture (as shown in the drawings), and if the particular gesture changes, the directional indication changes accordingly. Furthermore, the terms "comprise" and "have," as well as any variations thereof, are intended to cover a non-exclusive inclusion. A process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those listed but may optionally include other steps or elements not listed or inherent to such process, method, article, or apparatus.

Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the present application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those skilled in the art will explicitly and implicitly understand that the embodiments described herein may be combined with other embodiments.

Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a reagent supplying apparatus 10 provided in the present application, where the reagent supplying apparatus 10 in the present embodiment includes a reagent storage unit 11, a liquid adding unit 12 and a liquid draining unit 13.

In the present embodiment, the reagent storage unit 11 includes a reagent storage container 111, and it is understood that the reagent storage container 111 is used to store a reagent, and the reagent may be a reagent such as a hemolyzing agent for hemoglobin measurement, a hemolyzing agent for white blood cell analysis, a hemolyzing agent for nucleated red blood cell analysis, or a diluent for reticulocyte analysis, and the type of the specific reagent may be selected according to the actual detection requirements, and is not limited thereto.

Referring to fig. 2, fig. 2 is a schematic structural diagram of the reagent storage unit 11 in fig. 1, the reagent storage container 111 is formed with a liquid storage space 101, a reagent inlet 102, an air inlet 103 and a liquid outlet 104, the reagent inlet 102 is communicated with the liquid storage space 101, the air inlet 103 is communicated with the liquid storage space 101, and the liquid outlet 104 is communicated with the liquid storage space 101.

The filling unit 12 includes a filling tube 121 and a first power element 122, the filling tube 121 is in communication with the reagent storage container 111, the first power element 122 is in communication with the filling tube 121 to draw out a reagent through the filling tube 121 and inject the reagent into the reagent storage container 111, in this embodiment, the filling tube 121 is in communication with the liquid storage space 101 of the reagent storage container 111 through the reagent inlet 102 of the reagent storage container 111, and the first power element 122 injects the drawn reagent into the liquid storage space 101 of the reagent storage container 111 through the filling tube 121.

In practical applications, the first power element 122 may draw the reagent from the reagent tank M1 through the liquid drawing tube 121, and the first power element 122 may be a peristaltic pump.

The liquid discharging unit 13 includes the exhaust pipe 131, the second power element 132 and the liquid discharging pipe 133, the exhaust pipe 131 is communicated with the reagent storage container 111, in this embodiment, the exhaust pipe 131 is communicated with the liquid storage space 101 of the reagent storage container 111 through the air inlet 103 of the reagent storage container 111, the second power element 132 is communicated with the exhaust pipe 131 to supply positive pressure to the reagent storage container 111 through the exhaust pipe 131, in this embodiment, the second power element 132 injects air to the liquid storage space 101 of the reagent storage container 111 through the exhaust pipe 131 to form positive pressure in the reagent storage container 111, the liquid discharging pipe 133 is communicated with the reagent storage container 111 to enable the reagent in the reagent storage container 111 to be discharged from the liquid discharging pipe 133 under the positive pressure, in this embodiment, the liquid discharging pipe 133 is communicated with the liquid storage space 101 of the reagent storage container 111 through the liquid discharging port 104 of the reagent storage container 111, and thus the supply of the reagent in the liquid storage space 101 is completed under the positive pressure.

Optionally, the reagent storage unit 11 in the present embodiment further includes a first detector 112, and the first detector 112 is configured to detect the amount of the reagent in the reagent storage container 111.

Specifically, in actual application, the first power element 122 injects the reagent into the reagent storage container 111 through the liquid feeding pipe 121, the first detector 112 detects the amount of the reagent in the reagent storage container 111 during the injection of the reagent, when the amount of the reagent reaches the preset amount of the reagent, the first power element 122 stops the injection, and then the second power element 132 injects the gas into the reagent storage container 111 through the gas discharging pipe 131, so that the reagent in the reagent storage container 111 is discharged from the liquid discharging pipe 133, and during the discharge of the reagent, the first power element 122 continues to inject the reagent into the reagent storage container 111 through the liquid feeding pipe 121, so that the supply of the reagent is continuously performed as described above.

The type of the first detector 112 may be selected according to the actual requirement, and the comparison is not limited, for example, the first detector 112 may be a liquid level detector that detects the amount of the reagent in the reagent storage container 111 by detecting the liquid level of the reagent in the reagent storage container 111, or for example, the first detector 112 may be a flow detector that detects the amount of the reagent in the reagent storage container 111 by detecting the liquid injection amount of the liquid injection tube 121.

Optionally, the liquid discharge unit 13 in this embodiment further includes a liquid discharge control element 134, and the liquid discharge control element 134 is mounted on the liquid discharge tube 133 to block or communicate the liquid discharge tube 133, that is, when the reagent in the reagent storage container 111 needs to be discharged through the liquid discharge tube 133, the liquid discharge control element 134 communicates with the liquid discharge tube 133 so that the liquid discharge tube 133 is in a conductive state, and when the reagent in the reagent storage container 111 does not need to be discharged through the liquid discharge tube 133, the liquid discharge control element 134 blocks the liquid discharge tube 133 so that the liquid discharge tube 133 is in a non-conductive state.

Referring to fig. 1 and 3 together, fig. 3 is a schematic diagram of another embodiment of the drain control element 134 in fig. 1.

In the embodiment shown in fig. 1, the drain control element 134 is an on-off valve, by which the conduction or non-conduction state of the drain pipe 133 is controlled.

In the embodiment shown in fig. 3, the liquid discharge control element 134 is a switching valve, the liquid discharge tube 133 includes a first branch 1331 and a second branch 1332, the first branch 1331 communicates with the common port of the reagent storage container 111 and the switching valve, the second branch 1332 communicates with the first branch of the switching valve, the first branch 1331 and the second branch 1332 are in a conductive state when the switching valve is switched to the common port and the first branch, and the first branch 1331 and the second branch 1332 are in a non-conductive state when the switching valve is switched to the common port and the second branch.

Referring to fig. 4, fig. 4 is a schematic diagram of another embodiment of the liquid discharge unit 13 in fig. 1, in which the liquid discharge unit 13 further includes a second detector 135, and the second detector 135 is configured to detect a liquid discharge amount or a liquid discharge speed of the liquid discharge pipe 133.

Specifically, the second detector 135 may be a flow detector or a flow velocity detector, and when the reagent in the reagent storage container 111 is discharged through the liquid discharge tube 133, the second detector 135 detects the liquid discharge amount or the liquid discharge velocity of the liquid discharge tube 133, so as to avoid that the liquid discharge amount or the liquid discharge velocity of the liquid discharge tube 133 is too large or the liquid discharge amount or the liquid discharge velocity of the liquid discharge tube 133 is too small, thereby affecting the supply of the reagent.

Referring to fig. 5, fig. 5 is a control schematic diagram of the reagent supplying apparatus 10 in fig. 1, the reagent supplying apparatus 10 in this embodiment further includes a controller 14, the controller 14 is electrically connected to the first detector 112 and/or the second detector 135, the first power element 122 is electrically connected to the controller 14, so that the controller 14 sends a corresponding control signal to the first power element 122 according to the detection signal of the first detector 112 and/or the second detector 135, so that the amount of the reagent discharged from the liquid discharge tube 133 is the same as the amount of the reagent injected from the liquid filling tube 121, or the difference between the two amounts is within a preset range, and the pressure in the reagent storage container 111 is in an equilibrium state, so that no obvious pressure fluctuation occurs, and the reagent storage container 111 can be continuously used for a long time.

For example, the first detector 112 is a liquid level detector, when the liquid discharge pipe 133 discharges the reagent in the reagent storage container 111, the liquid level detector detects the liquid level of the reagent in the reagent storage container 111 and sends a detection signal to the controller 14, then the controller 14 sends a corresponding control signal to the first power element 122 according to the detection signal, and the first power element 122 injects the reagent into the reagent storage container 111 through the liquid feeding pipe 121 according to the control signal, so that the liquid level of the reagent in the reagent storage container 111 is kept unchanged or is changed within a preset range; for another example, the second detector 135 is a flow detector, and when the liquid discharge tube 133 discharges the reagent in the reagent storage container 111, the flow detector detects the liquid discharge amount of the liquid discharge tube 133 and sends a detection signal to the controller 14, then the controller 14 sends a corresponding control signal to the first power element 122 according to the detection signal, and the first power element 122 injects the reagent into the reagent storage container 111 through the liquid adding tube 121 according to the control signal, so that the amount of the reagent injected into the reagent storage container 111 by the liquid adding tube 121 is the same as the liquid discharge amount of the liquid discharge tube 133, and the difference value between the two is within a preset range.

Referring to fig. 6, fig. 6 is a schematic diagram of another embodiment of the reagent supplying apparatus 20 provided in the present application, in which the number of reagent storage units 11, liquid adding units 12 and liquid draining units 13 is plural.

The plurality of reagent storage units 11, the plurality of liquid adding units 12 and the plurality of liquid discharging units 13 can simultaneously extract and discharge the reagent, so that the supply efficiency of the reagent is improved, and the plurality of liquid adding units 12 can simultaneously extract the reagent from the reagent bucket M1 in practical application.

It will be appreciated that the number of the reagent storage units 11, the filling units 12 and the draining units 13 may be set according to actual needs, which is not limited.

Further, the reagent supplying apparatus 20 of the present embodiment further includes a liquid inlet pipe 21, wherein the liquid inlet pipe 21 is respectively connected to the plurality of liquid adding pipes 121, so that the plurality of first power elements 122 respectively extract the reagent into the plurality of liquid adding pipes 122 through the liquid inlet pipe 21, and then inject the reagent into the plurality of reagent storage containers 111.

Further, the reagent supplying apparatus 20 in the present embodiment further includes a liquid pumping unit 22, the liquid pumping unit 22 includes a third power element 221 and a liquid pumping tube 222, the liquid pumping tube 222 is communicated with the liquid inlet tube 21, and the third power element 221 is communicated with the liquid pumping tube 222 to pump the reagent to the liquid inlet tube 21 through the liquid pumping tube 222.

Specifically, during practical application, the third power element 221 extracts the reagent to the liquid inlet tube 21 through the liquid suction tube 222, then the plurality of first power elements 122 extract the reagent in the liquid inlet tube 21 to the plurality of liquid adding tubes 122 respectively, and finally the plurality of reagent storage containers 111 are injected respectively, so that the extraction efficiency of the reagent is improved, and the supply efficiency of the reagent is further improved.

In this embodiment, the liquid extraction tube 222 includes a first tube 2221 and a second tube 2222, the liquid extraction unit 22 further includes a waste liquid storage container 223, the first tube 2221 is respectively communicated with the liquid inlet tube 21 and the waste liquid storage container 223, the second tube 2222 is respectively communicated with the waste liquid storage container 223 and the third power element 221, the third power element 221 is used for providing a negative pressure to the waste liquid storage container 223 through the second tube 2222, so that the reagent is extracted to the liquid inlet tube 21 under the action of the negative pressure, that is, the third power element 221 is extracted from the waste liquid storage container 223 through the second tube 2222, so that the negative pressure is formed in the waste liquid storage container 223, and then the reagent is extracted to the liquid inlet tube 21 under the action of the negative pressure.

The liquid inlet tube 21 has a first opening 21a and a second opening 21b, the liquid inlet tube 21 is used for extracting the reagent through the first opening 21a, in this embodiment, the liquid inlet tube 21 is used for extracting the reagent from the reagent bucket M1 through the first opening 21a, the second opening 21b is communicated with the first pipeline 2221, and the liquid adding tube 121 is communicated between the first opening 21a and the second opening 21 b.

It will be appreciated that in practical applications, it may not be guaranteed that the reagent is drawn only to the inlet tube 21 and also to the outlet tube 222, and therefore the waste liquid storage container 223 in this embodiment is also capable of storing the reagent drawn into the outlet tube 222.

The pumping tube 222 is connected to a pumping control element 224, and the pumping control element 224 is connected to the pumping tube 222, so that the pumping tube 222 is in a conductive or non-conductive state, and in this embodiment, the pumping control element 224 is connected to a first pipeline 2221.

It is understood that the liquid sucking control element 224 may be an on-off valve or an electromagnetic valve, and the principle thereof is the same as that of the liquid discharging control element 134, which is not described herein.

The embodiment of the application also provides a sample analyzer, which comprises the reagent supply device and the detection device in any embodiment, wherein the detection device is used for detecting the sample after the reaction with the reagent.

Unlike the prior art, the reagent supplying apparatus provided in the embodiment of the present application includes: a reagent storage unit including a reagent storage container; the liquid adding unit comprises a liquid adding pipe and a first power element, wherein the liquid adding pipe is communicated with the reagent storage container, and the first power element is communicated with the liquid adding pipe so as to extract the reagent through the liquid adding pipe and inject the reagent into the reagent storage container; the liquid discharge unit comprises an exhaust pipe, a second power element and a liquid discharge pipe, wherein the liquid discharge pipe is communicated with the reagent storage container, the second power element is communicated with the exhaust pipe so as to provide positive pressure for the reagent storage container through the exhaust pipe, the liquid discharge pipe is communicated with the reagent storage container so that reagents in the reagent storage container are discharged from the liquid discharge pipe under the action of the positive pressure.

The foregoing is only a part of the embodiments of the present application, and is not intended to limit the scope of the present application, and all equivalent devices or equivalent process transformations made by using the descriptions and the contents of the present application, or direct or indirect application to other related technical fields, are included in the scope of patent protection of the present application.

Claims (10)

1. A reagent supply device, characterized in that the reagent supply device comprises:

a reagent storage unit including a reagent storage container;

the liquid adding unit comprises a liquid adding pipe and a first power element, wherein the liquid adding pipe is communicated with the reagent storage container, and the first power element is communicated with the liquid adding pipe so as to extract the reagent through the liquid adding pipe and inject the reagent into the reagent storage container;

the liquid draining unit comprises an exhaust pipe, a second power element and a liquid draining pipe, wherein the liquid draining pipe is communicated with the reagent storage container, the second power element is communicated with the exhaust pipe so as to provide positive pressure for the reagent storage container through the exhaust pipe, and the liquid draining pipe is communicated with the reagent storage container so that reagents in the reagent storage container are discharged from the liquid draining pipe under the action of the positive pressure.

2. The reagent supply device according to claim 1, wherein the liquid discharge unit further comprises a liquid discharge control member mounted on the liquid discharge pipe to shut off or communicate the liquid discharge pipe.

3. The reagent supply device according to claim 1, wherein the reagent storage unit further comprises a first detector for detecting the amount of reagent in the reagent storage container.

4. A reagent supplying apparatus according to claim 3, wherein the liquid discharge unit further includes a second detector for detecting a liquid discharge amount or a liquid discharge speed of the liquid discharge pipe.

5. The reagent supplying apparatus according to claim 4, further comprising a controller electrically connected to the first detector or the second detector, the first power element being electrically connected to the controller such that the controller sends a corresponding control signal to the first power element according to a detection signal of the first detector or the second detector.

6. The reagent supplying apparatus according to claim 1, wherein the number of the reagent storage unit, the liquid charging unit and the liquid discharging unit is plural, respectively, and the reagent supplying apparatus further comprises liquid feeding pipes which are respectively communicated with the plural liquid charging pipes, so that the plural first power elements extract the reagent to the plural liquid charging pipes through the liquid feeding pipes, respectively.

7. The reagent supply of claim 6, further comprising a pumping unit comprising a third power element and a pumping tube, the pumping tube in communication with the feed tube, the third power element in communication with the pumping tube to pump the reagent through the pumping tube to the feed tube.

8. The reagent supply device according to claim 7, wherein the liquid extracting unit further comprises a waste liquid storage container, the liquid extracting tube comprises a first pipeline and a second pipeline, the first pipeline is respectively communicated with the liquid inlet tube and the waste liquid storage container, the second pipeline is respectively communicated with the waste liquid storage container and the third power element, and the third power element is used for providing negative pressure to the waste liquid storage container through the second pipeline so that the reagent is extracted to the liquid inlet tube under the action of the negative pressure.

9. The reagent supplying apparatus according to claim 8, wherein the liquid inlet pipe has a first opening through which the reagent is drawn and a second opening communicating with the first pipe, and the liquid charging pipe communicates between the first opening and the second opening.

10. A sample analyzer comprising the reagent supply device according to any one of claims 1 to 9 and a detection device for detecting a sample after reaction with the reagent.

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