CN219032135U - Nucleic acid extraction device and nucleic acid detection equipment - Google Patents
Nucleic acid extraction device and nucleic acid detection equipment Download PDFInfo
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- CN219032135U CN219032135U CN202223507524.9U CN202223507524U CN219032135U CN 219032135 U CN219032135 U CN 219032135U CN 202223507524 U CN202223507524 U CN 202223507524U CN 219032135 U CN219032135 U CN 219032135U
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- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 59
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 59
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 59
- 238000000605 extraction Methods 0.000 title claims abstract description 36
- 238000001514 detection method Methods 0.000 title abstract description 13
- 239000011148 porous material Substances 0.000 claims abstract description 83
- 238000002955 isolation Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 abstract description 11
- 230000000712 assembly Effects 0.000 abstract description 9
- 238000000429 assembly Methods 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 6
- 230000006978 adaptation Effects 0.000 abstract description 3
- 239000011324 bead Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000005484 gravity Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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Abstract
The utility model provides a nucleic acid extraction device and nucleic acid detection equipment, which belong to the technical field of detection equipment, and the nucleic acid extraction device comprises: a magnetic bar assembly; a magnetic rod sleeve assembly; a pore plate seat; a first moving assembly having a first driving motor and a second driving motor; the second moving assembly is provided with a third driving motor; the third moving assembly has a fourth drive motor. The magnetic rod assembly and the magnetic rod sleeve assembly are moved in the horizontal direction and the vertical direction through the first moving assembly and the second moving assembly, the nucleic acid extraction process of the magnetic rod assembly and the magnetic rod sleeve assembly is guaranteed, when the number of the magnetic rod assemblies is different from the number of holes of the pore plate, the magnetic rod assemblies use single-row holes in the use process, the pore plate seat is driven to move in the extending direction of the vertical pore plate seat through the third moving assembly, the magnetic rod assemblies can use double-row holes, the adaptation between the number of the magnetic rod assemblies and the magnetic rod sleeve assemblies and the number of the holes of the pore plate seat are different is realized, and the overall detection efficiency is improved.
Description
Technical Field
The utility model relates to the technical field of detection equipment, in particular to a nucleic acid extraction device and nucleic acid detection equipment.
Background
In the fields of biotechnology and chemical analysis, an automatic nucleic acid extraction process is used for automatically extracting sample nucleic acid, is an important pretreatment link in nucleic acid detection, and the working principle of the nucleic acid extraction process is that magnetic beads are used as carriers, and the nucleic acid extraction and purification process is realized by moving the magnetic beads or transferring liquid by utilizing the principle that the magnetic beads adsorb nucleic acid under high salt and low pH value and separate the nucleic acid under low salt and high pH value. In automatic nucleic acid extraction, magnetic beads are transferred by a magnetic rod method, wherein the magnetic rod method is to place a magnetic rod in a magnetic rod sleeve, then the magnetic rod sleeve is placed in a sample pore plate, the size of attractive force of the magnetic beads is adjusted by adjusting the position of the magnetic rod in the magnetic rod sleeve, and each sample pore uses one magnetic rod, so that the purpose of transferring nucleic acid is achieved.
In the automatic nucleic acid extraction process, the number of magnetic rods determines the number of samples which can be operated at a time, and the number of the magnetic rods and the number of holes of the magnetic rod sleeve are the same as the number of holes of a sample pore plate, and the prior art generally adopts a 96 pore plate or a 48 pore plate. In the actual use process, the 48-pore plate and the 96-pore plate are required to be switched according to the number of samples and the like, but the matched magnetic rod and the magnetic rod sleeve are required to be replaced together in each switching, the time and the labor are wasted, the whole detection efficiency is low,
in the prior art, the number of the magnetic bars is the same as the number of holes of the magnetic bar sleeves and the number of holes of the sample pore plates, the actual practice is generally 96 pore plates and 48 pore plates, the actual requirements can be switched between the 48 pore plates and the 96 pore plates, the matched magnetic bars and the magnetic bar sleeves need to be replaced together every time, the problems of time and labor waste exist, and even the overall detection efficiency can be influenced.
Disclosure of Invention
Therefore, the technical problem to be solved by the utility model is to overcome the defect that the matched magnetic rod and the magnetic rod sleeve are required to be replaced together in each switching in the prior art, so as to provide the nucleic acid extraction device and the nucleic acid detection equipment.
In order to solve the above problems, the present utility model provides a nucleic acid extraction device comprising:
a magnetic bar assembly having two or more magnetic bar rows having a plurality of magnetic bars;
the magnetic rod sleeve assembly is provided with a magnetic rod sleeve corresponding to the magnetic rod array;
the pore plate seat is provided with at least one pore plate groove for placing the pore plate, the pore plate is provided with a plurality of rows of reaction holes, and the number of each row of reaction holes is the same as that of each row of magnetic rod rows;
the first moving assembly is provided with a first driving motor and a second driving motor, and the first driving motor drives the magnetic rod assembly to move in the vertical direction; the second driving motor drives the magnetic rod sleeve assembly to move in the vertical direction;
the second moving assembly is provided with a third driving motor, and the third driving motor drives the magnetic rod assembly and the magnetic rod sleeve assembly to move in a horizontal first direction;
and the third moving assembly is provided with a fourth driving motor, the fourth driving motor drives the orifice plate seat to move in a horizontal second direction, and the horizontal second direction is perpendicular to the horizontal first direction.
Preferably, the number of the reaction holes of the pore plate is an integer multiple of the number of the magnetic rod rows.
As a preferable scheme, the orifice plate seat is provided with a first station in the horizontal second direction, and when the fourth driving motor drives the orifice plate seat to move to the first station, single-column reaction holes of the orifice plates on the orifice plate seat are in one-to-one correspondence with the magnetic bar rows.
As a preferable scheme, the orifice plate seat is further provided with a second station in the horizontal second direction, and when the fourth driving motor drives the orifice plate seat to move to the second station, the double-array reaction holes of the orifice plate on the orifice plate seat are in one-to-one correspondence with the magnetic bar arrays.
As a preferable scheme, the number of the hole plate reaction hole columns is the same as that of the magnetic bar columns, the hole plate seat is further provided with a third station in the horizontal second direction, and when the hole plate seat is driven by the fourth driving motor to move to the third station, the reaction holes of the hole plate on the hole plate seat are in one-to-one correspondence with the magnetic bar columns.
Preferably, the third station is located between the first station and the second station, and the distance from the third station to the first station is equal to the distance from the third station to the second station.
Preferably, the magnetic rod assembly has 6 magnetic rod rows, and each magnetic rod row has 8 magnetic rods.
Preferably, the well plate groove is used for placing a 48-well plate or a 96-well plate.
Preferably, the method further comprises: the anti-drip disc is arranged below the magnetic rod sleeve component in a sliding manner.
Preferably, the plurality of orifice plate slots are arranged in parallel along the horizontal first direction and are used for placing orifice plates with at least one specification.
According to another aspect of the present application, there is also provided a nucleic acid detecting apparatus including the above-described nucleic acid extracting device.
The technical scheme of the utility model has the following advantages:
1. the nucleic acid extraction device provided by the utility model comprises: a magnetic bar assembly having two or more magnetic bar rows having a plurality of magnetic bars; the magnetic rod sleeve assembly is provided with a magnetic rod sleeve corresponding to the magnetic rod array; the pore plate seat is provided with at least one pore plate groove for placing the pore plate, the pore plate is provided with a plurality of rows of reaction holes, and the number of each row of reaction holes is the same as that of each row of magnetic rod rows; the first moving assembly is provided with a first driving motor and a second driving motor, and the first driving motor drives the magnetic rod assembly to move in the vertical direction; the second driving motor drives the magnetic rod sleeve assembly to move in the vertical direction; the second moving assembly is provided with a third driving motor, and the third driving motor drives the magnetic rod assembly and the magnetic rod sleeve assembly to move along the extending direction of the pore plate seat in the horizontal direction; the third moving assembly is provided with a fourth driving motor, the fourth driving motor drives the orifice plate seat to move, and the moving direction is perpendicular to the extending direction of the orifice plate seat. The device realizes the movement of the magnetic rod assembly and the magnetic rod sleeve assembly in the horizontal direction and the vertical direction through the first moving assembly and the second moving assembly, ensures the nucleic acid extraction process of the magnetic rod assembly and the magnetic rod sleeve assembly, and when the number of the magnetic rod assemblies is smaller than the number of holes of the pore plate, the magnetic rod assembly only uses the single row of holes in the use process, and drives the pore plate seat to move in the vertical pore plate seat extending direction through the third moving assembly, so that the magnetic rod assembly can use the double rows of holes, and the adaptation between the different numbers of the magnetic rod assembly and the magnetic rod sleeve assembly and the hole number of the pore plate seat is realized, thereby increasing the overall detection efficiency.
2. According to the nucleic acid extraction device provided by the utility model, the drip-proof disc is arranged below the magnetic rod sleeve assembly, so that the magnetic rod sleeve assembly possibly carries excessive liquid on the surface of the magnetic beads in the process of transferring nucleic acid every time, the excessive liquid can fall down under the action of gravity, the falling liquid can be caught by the drip-proof disc, other pore plates are prevented from being polluted, and the practicability of the device is improved.
3. The nucleic acid extraction device provided by the utility model is provided with the fourth moving mechanism, the fourth moving mechanism is provided with the fifth driving motor, and the drip-preventing plate is driven by the fifth driving motor to move along the extending direction of the pore plate seat, so that the drip-preventing plate can synchronously move along with the magnetic rod sleeve component, the magnetic rod sleeve component is ensured not to pollute other pore plates in the whole process, and the practicability of the device is improved.
4. According to the nucleic acid extraction device provided by the utility model, the first conveyor belt is connected with the output end of the third driving motor, the first conveyor belt is fixedly connected with the first moving assembly, the third driving motor is connected with the first moving assembly through the first conveyor belt, the first moving assembly is fixedly connected with the conveyor belt and moves along with the movement of the first conveyor belt, and the practicability of the device is improved by utilizing the advantages of small noise and small friction of the conveyor belt.
5. According to the nucleic acid extraction device provided by the utility model, the first sliding rails are further arranged for further increasing the stability of the first conveyor belt, the first sliding rails are provided with two groups, the first sliding rails are distributed on two sides of the first conveyor belt, and the first moving assembly is arranged on the first sliding rails in a sliding manner, so that the first moving assembly moves more stably in the horizontal direction.
6. According to the nucleic acid extraction device provided by the utility model, the second conveyor belt is connected with the fifth driving motor, the second conveyor belt is fixedly connected with the drip-proof disc, the fifth driving motor is connected with the drip-proof disc through the second conveyor belt, the drip-proof disc is fixedly connected with the conveyor belt and moves along with the movement of the second conveyor belt, and the practicability of the device is improved by utilizing the advantages of small noise and small friction force of the conveyor belt.
7. According to the nucleic acid extraction device provided by the utility model, the second slide rails are further arranged for further increasing the stability of the second conveyor belt, the second slide rails are provided with two groups, the second slide rails are distributed on two sides of the second conveyor belt, and the drip-preventing disc is arranged on the second slide rails in a sliding manner, so that the drip-preventing disc is more stable in movement in the horizontal direction.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram showing the overall structure of a nucleic acid isolation apparatus according to the present utility model.
Fig. 2 is a schematic diagram of a first moving assembly of a nucleic acid isolation apparatus according to the present utility model.
FIG. 3 is a schematic diagram showing switching of different well plates of a nucleic acid extraction device according to the present utility model.
Reference numerals illustrate:
1. a magnetic bar assembly; 2. a magnetic rod sleeve assembly; 3. a pore plate seat; 4. a first driving motor; 5. a second driving motor; 6. a third driving motor; 7. a fourth driving motor; 8. an anti-drip tray; 9. a first conveyor belt; 10. a first slide rail; 11. a second conveyor belt; 12. a second slide rail; 13. and a fifth driving motor.
Detailed Description
The following description of the embodiments of the present utility model will be made apparent and fully in view of the accompanying drawings, in which some, but not all embodiments of the utility model are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
In addition, the technical features of the different embodiments of the present utility model described below may be combined with each other as long as they do not collide with each other.
Referring to fig. 1, 2 and 3, a nucleic acid extraction apparatus provided in one embodiment includes: the magnetic rod assembly 1 is provided with more than two magnetic rod rows, and each magnetic rod row is provided with a plurality of magnetic rods; the magnetic rod sleeve assemblies 2 are provided with the magnetic rod sleeves the same as the magnetic rods in number, and the arrangement of the magnetic rod sleeves corresponds to that of the magnetic rod columns; the orifice plate seat 3 is provided with at least one orifice plate slot for placing an orifice plate, the orifice plate is provided with a plurality of rows of reaction holes, and the number of the reaction holes in each row is the same as that of the magnetic rod rows in each row.
Preferably, the plurality of orifice plate slots are arranged in parallel along the horizontal first direction and are used for placing orifice plates with at least more than one specification. The size of the pore plate slot position can be customized according to the pore plate specification, and the same pore plate can be placed in the pore plate slot position, or pore plates with different specifications, such as 48 pore plates and 96 pore plates, can be placed in the pore plate slot position, and the number of the pore plates is a multiple of the number of magnetic bars; the first moving assembly is provided with a first driving motor 4 and a second driving motor 5, and the first driving motor 4 drives the magnetic rod assembly 1 to move in the vertical direction; the second driving motor 5 drives the magnetic rod sleeve assembly 2 to move in the vertical direction; the second moving assembly is provided with a third driving motor 6, and the third driving motor 6 drives the magnetic rod assembly 1 and the magnetic rod sleeve assembly 2 to move in a horizontal first direction, wherein the horizontal first direction moves along the extending direction of the orifice plate seat 3 in the scheme; the third moving assembly is provided with a fourth driving motor 7, the fourth driving motor 7 drives the orifice plate base 3 to move in a horizontal second direction, the horizontal second direction is perpendicular to the horizontal first direction, and the horizontal second direction is perpendicular to the extending direction of the orifice plate base 3 in the scheme.
According to the device, the magnetic rod assembly 1 and the magnetic rod sleeve assembly 2 are moved in the horizontal direction and the vertical direction through the first moving assembly and the second moving assembly, the nucleic acid extraction process of the magnetic rod assembly 1 and the magnetic rod sleeve assembly 2 is guaranteed, when the number of the magnetic rod assemblies 1 is smaller than that of holes of a pore plate, the magnetic rod assembly 1 only uses single-row holes in the using process, in the scheme, the magnetic rod weighing assembly 1 arranged in the second horizontal direction is defined as a row, the magnetic rod assembly arranged in the first horizontal direction is defined as a column, the pore plate seat 3 is driven to move in the extending direction of the vertical pore plate seat 3 through the third moving assembly, the magnetic rod assembly 1 can use double-row holes, and the adaptation between the number of the magnetic rod assemblies 1 and the magnetic rod sleeve assembly 2 and the number of the holes of the pore plate seat 3 are different is realized, so that the overall detection efficiency is increased.
In the nucleic acid extraction device provided in one embodiment, the number of reaction well columns of the well plate is an integer multiple of the number of the magnetic rod columns, the well plate groove is used for placing a 48-well plate or a 96-well plate, the magnetic rod assembly is provided with 6 magnetic rod columns, each magnetic rod column is provided with 8 magnetic rods, namely, the number of the magnetic rods is 48, the magnetic rods are arranged at 6X8, and the number of the wells of the well plate is 48 or 96. The orifice plate seat has first station, second station and third station in horizontal second direction, and when 96 orifice plates were placed to the orifice plate seat, fourth driving motor drive orifice plate seat moved to when first station, 96 orifice plates on the orifice plate seat the singular of orifice plate be listed as the reaction hole with a plurality of bar magnet are listed as one-to-one, later fourth driving motor removes first distance in horizontal second direction, reach the second station for 96 orifice plates on the orifice plate seat the double-column reaction hole with a plurality of bar magnet are listed as one-to-one. When the 48 pore plates are placed on the pore plate seat, it can be understood that the 48 pore plates can be replaced on the original pore plate groove after the nucleic acid extraction is completed by the 96 pore plates, and the 48 pore plates can also be moved above the other pore plate groove for placing the 48 pore plates on the pore plate seat in the horizontal first direction through the magnetic rod assembly. The fourth driving motor drives the orifice plate seat to move a second distance in the horizontal second direction to reach a third station, so that the reaction Kong Cibang columns of the 48 orifice plates on the orifice plate seat are in one-to-one correspondence, the first distance is twice the second distance, the third station is positioned between the first station and the second station, and the distance from the third station to the first station is equal to the distance from the third station to the second station.
It should be noted that, in this embodiment, the single-number columns and the double-number columns refer to magnetic bar columns that are arranged in the horizontal first direction and are numbered sequentially, for example, 1, 2, 3, 4, 5, 6, or 2, 3, 4, 5, 6, and 7, that is, the single-number columns and the double-number columns refer to No. 1 from the first column in the horizontal first direction of the well plate, and may also refer to No. 2 from the even number, so it should be understood that the single-number columns and the double-number columns in this embodiment are only for distinguishing adjacent positions of the well plate, and are not limited by the single-number columns and the double-number columns of the well plate reaction well columns themselves.
The present embodiment places 48-well plates and 96-well plates in the well plate holder 3 according to capacity requirements. When 48 pore plates and 96 pore plates are placed in the pore plate seat, 48 magnetic rods only need to correspond to the pore positions of the 48 pore plates when the 48 pore plates are used, when the 48 pore plates are switched to the 96 pore plates, only the third moving assembly is needed to drive the pore plate seat to move the distance of half pore positions in the 48 pore plates in the direction of the vertical pore plate seat 3, at the moment, the magnetic rods just correspond to the singular rows or the double rows in the 96 pore plates, and further, the singular rows and the double rows in the 96 pore plates are selected by changing the positive and negative directions of the pore plate seat 3 in the vertical pore plate seat. The 96 pore plates are divided into single lines and double lines, the position of the pore plate seat 3 is changed through the third moving assembly, the 96 pore plates are split into two 48 pore plates for use, and the magnetic bars are switched between the 48 pore plates and the 96 pore plates.
Alternatively to this, the method may comprise,
the embodiment of the utility model provides a nucleic acid extraction device, still include anti-drip tray 8, anti-drip tray 8 sets up in the below of bar magnet cover subassembly 2, bar magnet cover subassembly 2 is carrying on the nucleic acid transfer in-process at every turn, the magnetic bead surface is likely to carry too much liquid, too much liquid can be low under the effect of gravity at this moment, the liquid of low drop can be caught by anti-drip tray 8, the practicality of anti-drip tray 8 has been avoided polluting other orifice plates, further increase, be provided with fourth moving mechanism, fourth moving mechanism has fifth driving motor 13, drive anti-drip tray 8 through fifth driving motor 13 and remove along the extending direction of orifice plate seat 3, make anti-drip tray 8 can follow bar magnet cover subassembly 2 synchronous motion, guarantee that bar magnet cover subassembly 2 whole journey does not pollute other orifice plates, increase the practicality of this device.
The embodiment of the utility model provides a nucleic acid extraction device, still include first conveyer belt 9, first conveyer belt 9 is connected with the output of third driving motor 6, first conveyer belt 9 and first removal subassembly fixed connection, be connected with first removal subassembly with third driving motor 6 through first conveyer belt 9, first removal subassembly and conveyer belt fixed connection, and remove along with first conveyer belt 9 removal, utilize the conveyer belt noise little, the advantage that frictional force is little, in order to further increase the stability of first conveyer belt 9 still be provided with first slide rail 10, first slide rail 10 has two sets of, first slide rail 10 distributes in the both sides of first conveyer belt 9, with first removal subassembly slip setting at first slide rail 10, make the removal of first removal subassembly in the horizontal direction more stable.
The nucleic acid extraction device provided in the embodiment further comprises a second conveyor belt 11, the second conveyor belt 11 is connected with a fifth driving motor 13, the second conveyor belt 11 is fixedly connected with the drip tray 8, the fifth driving motor 13 is connected with the drip tray 8 through the second conveyor belt 11, the drip tray 8 is fixedly connected with the conveyor belt and moves along with the movement of the second conveyor belt 11, the advantage of small noise and small friction force of the conveyor belt is utilized, a second slide rail 12 is further arranged for further increasing the stability of the second conveyor belt 11, the second slide rail 12 is provided with two groups, the second slide rails 12 are distributed on two sides of the second conveyor belt 11, and the drip tray 8 is slidably arranged on the second slide rail 12, so that the movement of the drip tray 8 in the horizontal direction is more stable.
Based on the same inventive concept, the present application also provides a nucleic acid detecting apparatus including the nucleic acid extracting apparatus in any one of the above embodiments.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. While still being apparent from variations or modifications that may be made by those skilled in the art are within the scope of the utility model.
Claims (11)
1. A nucleic acid extraction device, comprising:
a magnetic bar assembly having two or more magnetic bar rows having a plurality of magnetic bars;
the magnetic rod sleeve assembly is provided with a magnetic rod sleeve corresponding to the magnetic rod array;
the pore plate seat is provided with at least one pore plate groove for placing the pore plate, the pore plate is provided with a plurality of rows of reaction holes, and the number of the reaction holes in each row is the same as that of the magnetic rod rows in each row;
the first moving assembly is provided with a first driving motor and a second driving motor, and the first driving motor (4) drives the magnetic rod assembly to move in the vertical direction; the second driving motor drives the magnetic rod sleeve assembly (2) to move in the vertical direction;
the second moving assembly is provided with a third driving motor, and the third driving motor drives the magnetic rod assembly and the magnetic rod sleeve assembly to move in a horizontal first direction;
and the third moving assembly is provided with a fourth driving motor, the fourth driving motor drives the orifice plate seat to move in a horizontal second direction, and the horizontal second direction is perpendicular to the horizontal first direction.
2. The nucleic acid extraction device according to claim 1, wherein the number of columns of the well plate reaction wells is an integer multiple of the number of columns of magnetic rods.
3. The nucleic acid extraction apparatus according to claim 2, wherein the orifice plate holder has a first station in a horizontal second direction, and when the fourth driving motor drives the orifice plate holder to move to the first station, single-column reaction holes of the orifice plate on the orifice plate holder are in one-to-one correspondence with the plurality of magnetic rod columns.
4. The nucleic acid isolation apparatus according to claim 3, wherein the orifice plate holder further has a second station in a horizontal second direction, and when the fourth driving motor drives the orifice plate holder to move to the second station, the double-row reaction holes of the orifice plate on the orifice plate holder correspond to the plurality of magnetic bar rows one by one.
5. The nucleic acid extraction apparatus according to claim 4, wherein the number of reaction wells of the well plate is equal to the number of magnetic bar rows, the well plate holder further has a third station in a horizontal second direction, and when the fourth driving motor drives the well plate holder to move to the third station, the reaction wells of the well plate on the well plate holder are in one-to-one correspondence with the plurality of magnetic bar rows.
6. The nucleic acid extraction apparatus of claim 5, wherein the third station is located intermediate the first station and the second station, and wherein the distance from the third station to the first station is equal to the distance from the third station to the second station.
7. The nucleic acid isolation device of claim 6, wherein the magnetic rod assembly has 6 magnetic rod rows of 8 magnetic rods each.
8. The nucleic acid extraction apparatus of claim 7, wherein the well plate is configured to hold a 48-well plate or a 96-well plate.
9. The nucleic acid extraction apparatus according to any one of claims 1 to 8, further comprising:
and the anti-dripping disc (8) is arranged below the magnetic rod sleeve assembly (2) in a sliding manner.
10. The nucleic acid isolation apparatus according to any one of claims 1 to 8, wherein a plurality of well plate wells are provided, and a plurality of well plate wells are arranged in parallel in a first horizontal direction for placing well plates of at least one specification or more.
11. A nucleic acid detecting apparatus comprising the nucleic acid extracting device according to any one of claims 1 to 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223507524.9U CN219032135U (en) | 2022-12-26 | 2022-12-26 | Nucleic acid extraction device and nucleic acid detection equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223507524.9U CN219032135U (en) | 2022-12-26 | 2022-12-26 | Nucleic acid extraction device and nucleic acid detection equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219032135U true CN219032135U (en) | 2023-05-16 |
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|---|---|---|---|
| CN202223507524.9U Active CN219032135U (en) | 2022-12-26 | 2022-12-26 | Nucleic acid extraction device and nucleic acid detection equipment |
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| Country | Link |
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| CN (1) | CN219032135U (en) |
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- 2022-12-26 CN CN202223507524.9U patent/CN219032135U/en active Active
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