CN218980536U

CN218980536U - Preparation chromatographic column

Info

Publication number: CN218980536U
Application number: CN202222736295.1U
Authority: CN
Inventors: 方兴胜; 孙洪康; 方兴利
Original assignee: Jiangsu Zhirun Technology Co ltd
Current assignee: Jiangsu Zhirun Technology Co ltd
Priority date: 2022-10-18
Filing date: 2022-10-18
Publication date: 2023-05-09
Anticipated expiration: 2032-10-18

Abstract

The utility model relates to a preparation chromatographic column, which comprises a tank body, a split snap ring, an intermediate flange, a piston upper part, a piston lower part, a piston sealing ring, a hollow pipe, a packing, a belleville spring, a conical column, a locking bolt and the like, wherein the hollow pipe is connected with the piston upper part through internal and external threads and penetrates through a top cover, the belleville spring is arranged between the piston upper part and the top cover in the tank body, the piston upper part and the piston lower part are connected into a whole through the internal and external threads, the piston sealing ring is sleeved outside the piston lower part, the conical column is placed in a conical hole in the piston lower part, the locking bolt is connected with a threaded hole in the piston lower part and is pressed on the conical column upper part, the lower part of the tank body is matched with the bottom flange, a plane of the lower part of the tank body is connected with a sieve plate, and the packing is positioned in an inner space between the piston lower part and the sieve plate in the tank body. The preparation chromatographic column has the advantages of high efficiency, short separation and purification time, good separation effect and the like.

Description

Preparation chromatographic column

Technical Field

The utility model relates to the technical field of compression columns, in particular to a preparation chromatographic column.

Background

The purpose of analytical chromatography is to analyze the content of a pure substance (or substances) in a mixture. The purpose of preparative chromatography is to obtain pure material from a mixture. In order to accelerate the separation time and improve the separation efficiency, the sample injection amount of the preparation chromatograph is large, so that the separation load of the preparation chromatograph column is correspondingly increased, the filling of the chromatograph column is also required to be increased, the diameter and the length of the preparation chromatograph are increased, and relatively more mobile phases are used. However, when the sample load on the column is increased, the column efficiency tends to be drastically reduced, and a pure product is not obtained. The preparation of the chromatograph is to solve the contradiction between capacity and column effect, and the reproducibility is also considered. Economically, the preparation chromatography strives for less packing, less solvent and as much product as possible. The existing preparation chromatographic column has the characteristics of complex time structure, low efficiency and long separation and purification time.

Disclosure of Invention

Aiming at the defects of the prior art, the utility model provides a preparation chromatographic column which has the advantages of high efficiency, short separation and purification time, good separation effect and the like, and solves the problems of the existing preparation chromatographic column.

In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides a preparation chromatographic column, includes jar body, split snap ring, intermediate flange, sealing washer, top lid, sieve, bottom flange, stand, cup, piston upper portion, piston lower part, piston sealing washer, hollow tube, filler, belleville spring, toper post, locking bolt etc. hollow tube and piston upper portion are through inside and outside threaded connection together and pass the top lid, install belleville spring in jar body inside between piston upper portion and top lid, and belleville spring passes through the hollow tube external diameter, the intermediate flange is connected respectively in jar body upper portion, jar body lower part's position through split snap ring, piston upper portion, piston lower part adopt inside and outside threaded connection to be an integer, and piston upper portion, piston lower part all are in jar body central inner space, piston lower part outside cover has the piston sealing washer, the toper post is placed in the conical hole in the piston lower part, locking bolt is through the inside threaded connection with the piston lower part and is pressed in toper post upper portion, jar body lower part and bottom flange cooperation, and jar body lower part and bottom flange joint face's excircle have one, the flat surface is located the sieve in the inside the hollow flange, the hollow flange is located the inside the space between the stand, the stand is located at the inside and outside of the hollow flange.

Furthermore, cup sockets are sleeved on the three upright posts, so that noise is reduced in the moving, placing or using process of the preparation chromatographic column, and the purpose of protection is achieved;

further, the cup nest is made of nylon or rubber.

Further, the three upright posts are 120 degrees to each other, so that the chromatographic column is more stable and is not easy to topple.

Further, the central hole C at the lower part of the piston is gradually reduced in a stepped shape, at least three steps are formed in a stepped shape, the separation of the separated matters is more thorough, the efficiency is higher, and the quality is better.

Further, the central hole on the upper part of the piston is a through hole, and threads with different sizes are respectively arranged at two ends of the inside of the through hole so as to be better connected with the hollow tube and the lower part of the piston respectively, and a sufficient gap is reserved between the lower plane of the hollow tube and the upper plane of the lower part of the piston, so that the chromatographic column can be better maintained and maintained.

Further, plane A of the junction of bottom flange inside center and sieve is the center concave from the center to both sides, and the centre is protruding, and outside concave fluctuation step is formed again to it is steady to better place the sieve, and the separator separation is more thorough, and efficiency is higher, the quality is better.

Further, the center hole B on the plane of the joint of the inner center of the bottom flange and the sieve plate is amplified stepwise, at least stepwise three stages are formed, the separation of the separated matters is more thorough, the efficiency is higher, and the quality is better.

Further, the filler is a silica gel matrix or a polymer matrix or graphitized carbon or neutral alumina.

Compared with the prior art, the technical scheme of the application has the following beneficial effects:

1. the separation of the separated matters is more thorough, and the efficiency and the quality are higher.

2. Simple structure, and is convenient for better maintenance and maintenance to prepare the chromatographic column.

Drawings

FIG. 1 is a schematic diagram of the structure of the present utility model;

FIG. 2 is a top view of the present utility model;

FIG. 3 is an enlarged schematic view of the present utility model at I;

FIG. 4 is an enlarged schematic view of the utility model at II;

FIG. 5 is a schematic view of the internal structure of the bottom flange of the present utility model;

in the figure: the device comprises a tank body 1, a split snap ring 2, a middle flange 3, a sealing ring 4, a top cover 5, a sieve plate 6, a bottom flange 7, an upright post 8, a cup nest 9, a piston upper part 10, a piston lower part 11, a piston sealing ring 12, a hollow pipe 13, a packing 14, a belleville spring 15, a conical column 16 and a locking bolt 17.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

Referring to fig. 1, 2, 3 and 4, in this embodiment, a preparation chromatographic column is provided, and the present utility model provides the following technical scheme: a preparation chromatographic column comprises a tank body 1, a split snap ring 2, an intermediate flange 3, a sealing ring 4, a top cover 5, a screen plate 6, a bottom flange 7, a column 8, a cup 9, a piston upper part 10, a piston lower part 11, a piston sealing ring 12, a hollow tube 13, a packing 14, a belleville spring 15, a conical column 16, a locking bolt 17 and the like, wherein the hollow tube 13 is connected with the piston upper part 10 through internal and external threads and penetrates through the top cover 5, a belleville spring 15 is arranged between the piston upper part 10 and the top cover 5 in the tank body 1, the belleville spring 15 passes through the outer diameter of the hollow tube 13, the intermediate flange 3 is respectively connected to the upper part of the tank body 1 and the lower part of the tank body 1 through the split snap ring 2, the piston upper part 10 and the piston lower part 11 are connected into a whole through internal and external threads, the piston upper part 10 and the piston lower part 11 are both positioned in the central inner space of the tank body 1, the piston lower part 11 is sleeved with the piston sealing ring 12, the conical column 16 is placed in the conical hole in the piston lower part 11, the locking bolt 17 is connected with the inner side of the piston upper part 11 through the hollow tube 13 through the internal and external threads and the external threads, the hollow tube 15 is connected with the bottom flange 7 at the bottom of the column 7 and the bottom flange 7 in the bottom of the tank body 1 through the column 7, and the bottom flange 7 is connected to the bottom flange 7 in the bottom part of the tank body 1 through the upper part 6 and the bottom flange 7; cup sockets 9 are sleeved on the three upright posts 8, so that noise is reduced in the process of moving, placing or using the preparation chromatographic column, and the purpose of protection is achieved; the cup nest 9 is made of nylon or rubber; the three upright posts 8 are 120 degrees mutually, so that the chromatographic column is more stable and is not easy to fall down; the central hole C of the lower part 11 of the piston is gradually reduced in a stepped manner, at least three steps are formed in a stepped manner, and the separation of the separated matters is more thorough, and the efficiency and the quality are higher; the central hole of the upper part 10 of the piston is a through hole, and threads with different sizes are arranged at two ends of the inside of the through hole so as to be better connected with the hollow tube 13 and the lower part 11 of the piston respectively, and a sufficient gap is reserved between the lower plane of the hollow tube 13 and the upper plane of the lower part 11 of the piston so as to be convenient for better maintenance and preparation of the chromatographic column; the plane A at the joint of the inner center of the bottom flange 7 and the sieve plate 6 is concave from the center to two sides, the middle is convex, and the outer part is concave again to form a step shape, so that the sieve plate 6 can be placed stably better, the separation of the separated matters is more thorough, the efficiency is higher, and the quality is better; the center hole B on the plane where the inner center of the bottom flange 7 is connected with the sieve plate 6 is amplified stepwise, at least three steps are formed, the separation of the separated matters is more thorough, the efficiency is higher, and the quality is better; further, the filler 14 is a silica gel matrix or a polymer matrix or graphitized carbon or neutral alumina. .

The working principle of the embodiment is as follows: the mixed component sample to be separated is dissolved in the mobile phase, then the sample mixed liquid flows in through the hollow tube 13, and different component flow rates are different, so that the sample mixed liquid sequentially passes through the upper part 10 of the piston, the lower part 11 of the piston, the tank body 1 and the sieve plate 6 at different speeds, and finally flows out through the stepped central hole of the bottom flange 7, thereby achieving the purpose of separating the mixed component sample.

Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a preparation chromatographic column, includes jar body (1), split snap ring (2), intermediate flange (3), sealing washer (4), top lid (5), sieve (6), bottom flange (7), stand (8), cup (9), piston upper portion (10), piston lower part (11), piston sealing washer (12), hollow tube (13), packing (14), belleville spring (15), toper post (16), lock bolt (17), its characterized in that: the hollow tube (13) and the upper part (10) of the piston are connected together through internal and external threads and penetrate through the top cover (5), a belleville spring (15) is arranged between the upper part (10) of the piston and the top cover (5) in the tank body (1), the belleville spring (15) passes through the outer diameter of the hollow tube (13), the middle flange (3) is respectively connected to the upper part of the tank body (1) and the lower part of the tank body (1) through a split snap ring (2), the upper part (10) of the piston and the lower part (11) of the piston are connected into a whole through internal and external threads, the upper part (10) of the piston and the lower part (11) of the piston are both positioned in the central inner space of the tank body (1), a piston sealing ring (12) is sleeved outside the lower part (11) of the piston, a conical column (16) is arranged in a conical hole in the lower part (11), a locking bolt (17) is connected with a threaded hole in the lower part of the piston (11) and is pressed on the upper part of the conical column (16), the lower part (1) of the tank body is matched with the lower part (7) of the tank body and the lower part (7) of the tank body, the lower part (7) of the tank body is combined with the lower part (6) of the flange (7) of the tank body, the lower part is combined with the lower part (7) of the flange (6), the three upright posts (8) are uniformly distributed and connected in the bottom flange (7) through internal and external threads, and the filler (14) is positioned in an inner space between the lower part (11) of the piston in the tank body (1) and the sieve plate (6).

2. A preparative chromatography column according to claim 1, wherein: cup sockets (9) are sleeved on the three upright posts (8).

3. A preparative chromatography column according to claim 1, wherein: the cup nest (9) is made of nylon or rubber.

4. A preparative chromatography column according to claim 2, wherein: the three columns (8) are 120 DEG to each other.

5. A preparative chromatography column according to claim 1, wherein: the central hole C of the lower part (11) of the piston is reduced stepwise and gradually in a step shape, and the step shape is three-stage.

6. A preparative chromatography column according to claim 1, wherein: the central hole of the upper part (10) of the piston is a through hole, threads with different sizes are arranged at two ends of the inside of the through hole, the through hole is respectively connected with the hollow pipe (13) and the lower part (11) of the piston, and a gap is reserved between the lower plane of the hollow pipe (13) and the upper plane of the lower part (11) of the piston.

7. A preparative chromatography column according to claim 1, wherein: the plane A at the joint of the inner center of the bottom flange (7) and the sieve plate (6) is concave from the center to the two sides, the middle is convex, and the outer part is concave again and is in a step shape.

8. A preparative chromatography column according to claim 1, wherein: the center hole B on the plane of the joint of the inner center of the bottom flange (7) and the sieve plate (6) is amplified in a stepped manner, and the stepped manner is three-stage.

9. A preparative chromatography column according to claim 1, wherein: the filler (14) is a silica gel matrix or a polymer matrix or graphitized carbon or neutral alumina.