CN116585752B - Chromatographic column and oscillating device for chromatographic column - Google Patents
Chromatographic column and oscillating device for chromatographic column Download PDFInfo
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- CN116585752B CN116585752B CN202310877816.1A CN202310877816A CN116585752B CN 116585752 B CN116585752 B CN 116585752B CN 202310877816 A CN202310877816 A CN 202310877816A CN 116585752 B CN116585752 B CN 116585752B
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- 230000010355 oscillation Effects 0.000 claims abstract description 21
- 239000000945 filler Substances 0.000 claims abstract description 12
- 230000007246 mechanism Effects 0.000 claims description 53
- 238000007789 sealing Methods 0.000 claims description 23
- 238000004587 chromatography analysis Methods 0.000 claims description 11
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 125000003003 spiro group Chemical group 0.000 claims description 3
- 229920001875 Ebonite Polymers 0.000 claims 1
- 238000012856 packing Methods 0.000 abstract description 13
- 238000010438 heat treatment Methods 0.000 abstract description 6
- 238000001816 cooling Methods 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 4
- 238000013375 chromatographic separation Methods 0.000 abstract 1
- 238000009434 installation Methods 0.000 description 15
- 230000033001 locomotion Effects 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 238000005491 wire drawing Methods 0.000 description 7
- 238000004440 column chromatography Methods 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000005526 G1 to G0 transition Effects 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
A chromatographic column and an oscillating device for the chromatographic column belong to the technical field of chromatographic separation, wherein the chromatographic column comprises an outer sleeve, an inner tube is arranged in the outer sleeve, two ends of the outer sleeve are respectively communicated with connectors, the outer sleeve is generally made of hard plastic, and the inner tube is a filling part of a filler. Simultaneously, the inner tube is conveniently heated or insulated in the mode, and the connector can be connected to cooling equipment or heating equipment when the inner tube is implemented, so that the inner tube is cooled or heated, and chromatographic operations are conveniently carried out on different substances in the cooling or heating mode. In addition, an oscillation device for a chromatographic column is used for eliminating gaps in a packing in the chromatographic column, thereby improving column efficiency.
Description
Technical Field
The present invention relates to a chromatographic column, and more particularly, to a chromatographic column and an oscillation device for the chromatographic column.
Background
The known technology reports that the column chromatography separation technology is widely used in the fields of pharmaceutical industry, biochemical industry, food engineering and the like at present, and is one of important means for separating chemical products and preparing high-purity substances. Column chromatography separation techniques, also known as column chromatography techniques, are performed by filling an insoluble granular adsorbent in a chromatography column, forming a stationary phase by the adsorbent, adding a sample to be separated to the chromatography column, eluting with an eluent, forming a mobile phase by the eluent, and repeatedly distributing the components in the sample for a plurality of times according to different distribution coefficients of the components in the sample in the stationary phase and the mobile phase during elution of the sample from the column.
The column efficiency of the chromatographic column is determined by the packing method of the packing and the length of the column, and to improve the column efficiency, a proper packing method is generally adopted, and the height of the column is shortened. However, when the column efficiency is improved, gaps exist among particles of the filler when the filler is filled, the existence of the gaps can lead to the length of the column to be high, convection and vortex phenomena are formed in the gaps by liquid when chromatography is performed, and meanwhile, samples can be fully diffused in the gaps, so that the problem of partial loss of the column efficiency is caused.
The existing chromatographic column also has the problem that the height of the column is inconvenient to adjust, and a certain space is reserved between the liquid inlet end and the upper end of the column after filling, so that when liquid inlet chromatography is carried out, the upper end of the filler is easy to loose due to flushing and other reasons, namely the upper end of the column is easy to generate the pore as described above, and the column efficiency is reduced. Meanwhile, the currently used assembled chromatographic column has the problem that the sealing effect is to be improved.
Disclosure of Invention
The invention provides a chromatographic column and an oscillating device for the chromatographic column, which solve the defects in the prior art, improve the column efficiency of the chromatographic column by adjusting the suitability of the height of the column, and further improve the column efficiency of the chromatographic column by eliminating pores in an oscillating mode.
In order to achieve the object of the present invention, the following techniques are proposed:
in one aspect, the invention provides a chromatographic column comprising an outer sleeve, an inner tube is arranged in the outer sleeve, two ends of the outer sleeve are respectively communicated with connectors, the outer sleeve is generally made of hard plastic, and the inner tube is a filling part of a filler. Simultaneously, the inner tube is conveniently heated or insulated in the mode, and the connector can be connected to cooling equipment or heating equipment when the inner tube is implemented, so that the inner tube is cooled or heated, and chromatographic operations are conveniently carried out on different substances in the cooling or heating mode.
The both ends of outer tube spiro union respectively have the end cap, and the outside end of end cap is equipped with the sealing washer, and the sealing washer is located between outer tube and the inner tube, when connecting the equipment, with the sealing washer snare in the tip of inner tube to the bore of sealing washer is about to be far away be less than the external diameter of inner tube, can ensure sealed effect through this kind of mode, avoids the medium of heating or the problem that cooling medium can not take place to leak. The inner ring end face of the sealing ring is provided with a first conical surface, the inner side end of the first conical surface is a small end, the outer side end of the end cap is provided with an extension sleeve, a first end pipe is connected in the extension sleeve in a screwed mode, the inner side end of the first end pipe is provided with a conical ring, the periphery of the conical ring is of a conical structure, the conical ring penetrates through the first conical surface, and a gap between the sealing ring and the inner pipe can be reinforced and sealed through the conical ring and the arrangement of the first conical surface, so that leakage of heating or cooling mediums is further avoided. Meanwhile, the inner side end of the first end pipe plays a limiting role on the end part of the inner pipe, so that the inner pipe is prevented from moving after being fixed or during oscillation. The inner side end of the first end pipe acts on the end part of the inner pipe, the outer side end of the first end pipe is provided with a first screwing ring, and the first screwing ring is positioned at the outer side end of the outer extension sleeve.
The inner end of the first end pipe is connected with a movable pipe in a screwed mode, the inner side end of the movable pipe is welded with a plastic hose, the inner side end of the plastic hose is provided with a ring groove, a sealing ring is arranged in the ring groove, the inner wall of the inner side end of the plastic hose is provided with a conical head, the inner side end of the conical head is a small end, the outer side end of the movable pipe is provided with a second screwing ring, the inner side end of the movable pipe is connected with an inner supporting pipe in a screwed mode, and the inner supporting pipe is made of hard materials. The inner side end outer wall of the inner supporting tube is formed with a second conical surface, the inner side end of the second conical surface is a small end, the outer wall of the second conical surface acts on the conical surface of the conical head to enable the sealing ring to act on the inner wall of the inner tube, after the position of the inner side end of the movable tube is locked, the inner supporting tube can be rotated, the outer wall of the second conical surface acts on the conical surface of the conical head to enable the plastic hose to be outwards spread and deformed, the sealing ring is tightly attached to the inner wall of the movable tube, sealing between the inner side end of the movable tube and the inner tube is further carried out, the leakage problem is avoided in the mode, and the height of the inner packing in the inner tube is also conveniently adjusted in the mode of convenient sealing.
The inner side end of the inner supporting tube is internally connected with a filter head in a threaded manner. Through the filter head of convenient dismantlement, can carry out the suitability according to the size of the granule of packing and change, this kind of mode that packs both ends all set up the filter head simultaneously on the one hand conveniently carries out the regulation of packing column height, on the other hand can also ensure that the packing can not loosen.
The outer side end of the inner supporting tube is provided with a third screwing ring, the inner wall of the outer side end of the third screwing ring is provided with a third conical surface, the inner side end of the third conical surface is a small end, the outer side end of the inner supporting tube is in threaded connection with a second end tube, the outer wall of the inner side end of the second end tube is provided with a fourth conical surface, the inner side end of the fourth conical surface is a small end, the conical surface of the fourth conical surface acts on the inner wall of the third conical surface, the outer side end of the second end tube is provided with a fourth screwing ring, and the fourth screwing ring is provided with a connecting tube head. Through the setting of third conical surface and fourth conical surface, conveniently seal the outside end of interior stay tube through the second end pipe, the connecting pipe head of here, convenient and feed liquor pipe or drain pipe connection, and detachable mode is convenient with the pipe connection above that.
On the other hand, the invention provides an oscillating device for a chromatographic column, which comprises an oscillating mechanism, wherein the oscillating mechanism is provided with a mounting frame, the mounting frame is provided with a connecting mechanism, the connecting mechanism is provided with a clamping mechanism, and the clamping mechanism is used for clamping the chromatographic column. Compared with the prior disclosed technical content, the chromatographic column is conveniently fixed by adopting the clamping mechanism, so that the safety is ensured in the oscillating process. The connecting mechanism is also convenient for fixing the position of the clamping mechanism, and a plurality of clamping mechanisms can be arranged on the mounting frame, so that the chromatographic column is clamped and fixed through the plurality of clamping mechanisms. The oscillation mechanism can drive the chromatographic column to oscillate front and back and up and down, so that the pores in the filler are eliminated.
The oscillating mechanism comprises a box body, one side of the box body is provided with an opening, one side of the box body is connected with a box cover through a hinge, and the box cover is convenient to maintain oscillating components in the box body. The top cover plate of the box body is provided with a movable hole.
The motor mounting plate is arranged on the bottom plate of the box body, the motor is arranged on the motor mounting plate, the output shaft of the motor is connected with a rotating shaft through a coupling, a pair of shaft seats are arranged on the rotating shaft, the shaft seats are arranged on the bottom plate of the box body, the rotating shaft is eccentrically provided with an eccentric wheel, two ends of the eccentric wheel are respectively provided with a limiting disc, the limiting disc is concentric with the eccentric wheel, and the other end of the rotating shaft is provided with a rotating arm. The arrangement of the two shaft seats ensures the stability of the rotating shaft when the eccentric wheel is driven to rotate.
A pair of installation curb plates are installed on the bottom plate of box, and the convex guide is installed to the inner wall of installation curb plate, and the activity is equipped with the fly leaf between the convex guide, has seted up waist type hole on the fly leaf, and the eccentric wheel wears in waist type downthehole, and the limiting disc is located the both sides of fly leaf to ensure that the eccentric wheel can be located waist type downthehole all the time, thereby improved the stability when oscillating. A plurality of concave seats are arranged at two ends of the movable plate, the concave seats are sleeved on the convex guide piece, guide wheels are rotatably arranged at two sides of the concave seats, and the peripheral sides of the guide wheels are tangent to the outer wall of the convex guide piece. The male guide element not only serves as a guide, but also ensures the flexibility of the lifting movement by means of the guide wheel.
The other end of the rotating arm rotates and is equipped with first swing arm, the other end of first swing arm articulates there is the second swing arm, the middle part of second swing arm rotates and is equipped with the rotation seat, the rotation seat is installed on the lateral wall of box, the upper end of second swing arm articulates there is the even board, the other end of even board articulates there is the boss, movable curb plate is installed to the root of boss, the guide rail is installed to the dorsal part of movable curb plate, be the guide rail that transversely sets up, can ensure that the movable curb plate carries out horizontal reciprocating motion, the cover is equipped with the sliding sleeve on the guide rail, install the mount pad on the sliding sleeve, install movable upper plate on the mount pad, the installation deckle is installed to the lower wall of movable upper plate, the installation frame is installed to the lower extreme of installation deckle, install the oscillating plate on the movable curb plate, the oscillating plate wears in the movable hole. The oscillating plate can move horizontally forwards and backwards under the drive of the movable side plate, and meanwhile, the oscillating plate moves up and down under the cooperation of the eccentric wheel and the movable plate.
The mounting bracket is including installing a pair of guided way on the lamina tecti of installing in the box, and the cover is equipped with the slip cap on the guided way, and the stability of following oscillation bottom plate motion can be ensured in the setting of guided way and slip cap to play the effect of direction to the motion of oscillation bottom plate. The upper extension piece is installed respectively at the both ends of slip cap, and the cavity has been seted up to the inner wall of upper extension piece, is equipped with the guide arm in the cavity, and the activity is equipped with the movable seat on the guide arm, and the upper and lower both ends of guide arm overlap respectively and are equipped with the spring, and the setting of spring can improve the flexible buffering when oscillating. The two sides of the upper extension piece are provided with vertical holes, the movable seat is provided with a pair of convex rods, and the arrangement of the convex rods plays a role in guiding vertical movement. The protruding rod penetrates through the vertical hole, and two ends of the oscillating bottom plate are arranged on the movable seat through a plurality of connecting arm plates.
The oscillating bottom plate is installed to the oscillating plate upper end, installs the installation base on the oscillating bottom plate, installs on the installation base and extends the round bar, goes up to extend the round bar and overlaps on the round bar and be equipped with the cover seat, and the spiro union has locking screw on the cover seat, and locking screw's outside end is equipped with the handle, and the setting of handle is convenient to rotate the screw to the convenience is adjusted the height of cover seat. A centering rod is arranged between the sleeve seats. The middle rod is generally fixed on the sleeve seat in a threaded connection mode.
The connecting mechanism comprises a rectangular sleeve sleeved on the middle rod, a concave shell is mounted on the rectangular sleeve, a guide block is arranged on the inner wall of the other end of the concave shell, a concave frame is mounted at the upper end of the concave shell, a pull-up screw rod is connected to the upper end of the concave frame in a threaded mode, a rotating cap is arranged at the upper end of the pull-up screw rod, a movable block is rotatably arranged at the lower end of the pull-up screw rod, a guide groove is formed in the movable block, the guide block penetrates through the guide groove, a diagonal groove is formed in the inner wall of the movable block, the diagonal groove is of a triangular structure, the vertical surface of the diagonal groove is an inclined surface, a top wheel is tangent to the inclined surface of the diagonal groove, when the movable block moves, the top wheel acts on the inclined surface of the diagonal groove, so that the top wheel moves, a pair of transverse holes are formed in the concave shell, two ends of the top wheel penetrate through the transverse holes, an inner plate is arranged in the concave shell, a pair of ejector rods are penetrated on the inner plate, the outer side ends of the ejector rods are of the hemispherical structure, and the outer side ends of the ejector rods are tangent to the outer wall of the top wheel, and the top wheel is arranged when the movable block moves, so that the other end of the ejector rods moves towards the middle rod, and the position of the rectangular sleeve is locked. The inner side end of the ejector rod is of a pointed cone structure, and the pointed cone structure is arranged, so that when the ejector rod is propped against the middle rod, the position of the rectangular sleeve is conveniently fixed. The inner side end of the ejector rod is connected with an inner ring through a first pin, and the inner ring is used for limiting the outward movement length of the ejector rod. The ejector rod is sleeved with a second spring, the second spring is located on the outer side of the inner plate, the outer side end of the second spring is provided with an outer ring, the second spring acts on the outer ring, and when fixation is canceled, the inner side end of the second spring can be far away from the middle rod through the elastic force of the second spring, so that positioning operation is canceled conveniently. The outer ring is arranged on the outer side end of the ejector rod through the second pin, the inner side end of the ejector rod penetrates through the rectangular sleeve, and the inner side end of the ejector rod acts on the middle rod. The connecting mechanism is convenient to connect by means of interaction of the ejector rod and the middle rod through the single upper wire drawing rod.
The clamping mechanism comprises a mounting backboard arranged on a rectangular sleeve, a clamping table is arranged on the mounting backboard, a V-shaped clamping groove is formed in the outer side end of the clamping table, a pair of side plates are arranged on the mounting backboard, a first concave piece is arranged on the side plates in a rotating mode, a clamping piece is arranged on the first concave piece, a second concave piece is arranged on the lower end of the side plates in a rotating mode, an inner top screw rod is connected to the second concave piece in a threaded mode, a transverse ejector rod is arranged at the inner side end of the inner top screw rod, a handle rod is arranged at the outer side end of the inner top screw rod, a clamping block is arranged on the inner wall of the lower end of the clamping piece, a clamping inclined wall is formed in the outer wall of the lower end of the clamping piece, the clamping inclined wall is inclined downwards, a V-shaped groove is formed in the upper portion of the clamping inclined wall, and the periphery of the transverse ejector rod acts on the clamping inclined wall when the clamping block acts on the outer wall of a chromatographic column. The setting of V-arrangement draw-in groove and holder conveniently carries out the centre gripping to the chromatographic column and fixes, can also avoid simultaneously causing the damage to the outer wall of chromatographic column in order to improve the centre gripping effect simultaneously. The clamping piece can enable the clamping piece to act on the outer wall of the chromatographic column under the action of the transverse ejector rod, so that the chromatographic column is clamped and fixed. The arrangement of the clamping inclined wall can gradually improve the clamping stability when the transverse ejector rod rotates upwards, and the arrangement of the V-shaped groove can enable the upper end of the second concave piece to act on the lower wall of the V-shaped groove when the second concave piece rotates upwards, so that the clamping operation can be conveniently canceled.
The technical scheme has the advantages that:
on one hand, the chromatographic column provided by the invention has good sealing effect and is convenient for adjusting the height of the packing, so that the column efficiency is improved to a certain extent. On the other hand, the oscillation device is provided for oscillating the packing, so that the pores of the packing are eliminated, and the column efficiency is further improved.
Drawings
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail with reference to the accompanying drawings.
Fig. 1 shows a perspective view of an oscillation device for a column and a column.
Fig. 2 shows a perspective view of the upper case of the oscillating mechanism.
Fig. 3 shows a perspective view of a first part of the interior of the oscillating mechanism.
Fig. 4 shows a perspective view of the second part of the interior of the oscillating mechanism.
Fig. 5 shows an overall structure diagram of the oscillation mechanism from a first view.
Fig. 6 shows an overall structure diagram of the oscillation mechanism from a second view angle.
Fig. 7 shows a perspective structural view of the lower portion of the mounting bracket.
Fig. 8 shows a partial representation of the lower part of the mounting bracket.
Fig. 9 shows a perspective structural view of the upper portion of the mounting bracket.
Fig. 10 shows a diagram of the connection relationship between the connection mechanism and the mount.
Fig. 11 shows a perspective view of the connection mechanism.
Fig. 12 shows a perspective view of the inside of the connection mechanism.
Fig. 13 shows a perspective view of the clamping mechanism.
Fig. 14 shows a perspective view of the holding table.
Fig. 15 shows a perspective view of the clip.
Fig. 16 shows a structural view and a sectional view of a column, wherein the left side is a sectional view of the column, and the right side is a structural view of the column.
Fig. 17 shows a disassembled view of the internal structure of the column.
Reference numerals illustrate:
the device comprises an oscillating mechanism 1, a mounting frame 2, a connecting mechanism 3, a clamping mechanism 4, a chromatographic column 5, a box body 100, a hinge 101, a box cover 102, a movable hole 103, a motor mounting plate 104, a motor 105, a rotating shaft 106, a shaft seat 107, an eccentric wheel 108, a limit plate 109, a rotating arm 110, a mounting side plate 111, a convex guide 112, a movable plate 113, a waist-shaped hole 114, a concave seat 115, a guide wheel 116, a first swing arm 117, a second swing arm 118, a rotating seat 119, a connecting plate 120, a convex seat 121, a movable side plate 122, an oscillating plate 123, a sliding sleeve 124, a mounting seat 125, a movable upper plate 126, a mounting frame plate 127, a mounting frame 128, a guide rail 200, a sliding sleeve 201, an upper extension piece 202, a cavity 203, a vertical hole 204, a movable seat 205, a guide rod 206, a spring 207, a convex rod 208, a connecting arm plate 209, an oscillating bottom plate 210, a mounting base 211, an upper extension rod 212, a sleeve seat 213, a middle rod 214, a locking screw 215, a rectangular sleeve 300, concave housing 301, guide block 302, concave frame 303, upper wire drawing rod 304, rotating cap 305, movable block 306, guide groove 307, angular groove 308, top wheel 309, top rod 310, inner ring 311, second spring 312, outer ring 313, inner plate 314, mounting back plate 400, side plate 401, first concave member 402, clamping table 403, v-shaped clamping groove 404, second concave member 405, inner wire drawing rod 406, handle rod 407, cross top rod 408, clamping member 409, clamping block 410, clamping inclined wall 411, v-shaped groove 412, outer sleeve 500, connector 501, inner tube 502, end cap 503, sealing ring 504, first tapered surface 505, outer sleeve 506, first end tube 507, first tapered ring 508, tapered ring 509, movable tube 510, tapered head 511, sealing ring 512, inner support tube 513, second tapered surface 514, third tapered surface 516, fourth tapered ring 515, fourth tapered ring 518, connecting tube 519, second tapered ring 520.
Description of the embodiments
Example 1
The embodiment provides a chromatographic column 5 as shown in fig. 16, which comprises an outer sleeve 500, wherein an inner tube 502 is arranged in the outer sleeve 500, and two ends of the outer sleeve 500 are respectively communicated with a connector 501.
As shown in fig. 17, both ends of the outer sleeve 500 are respectively screwed with end caps 503, the outer end of the end caps 503 is provided with a sealing ring 504, the sealing ring 504 is positioned between the outer sleeve 500 and the inner tube 502, a first conical surface 505 is formed on the inner end surface of the sealing ring 504, the inner end of the first conical surface 505 is a small end, the outer end of the end caps 503 is provided with an extension sleeve 506, a first end tube 507 is screwed in the extension sleeve 506, the inner end of the first end tube 507 is provided with a conical ring 509, the periphery of the conical ring 509 is in a conical structure, the conical ring 509 penetrates through the first conical surface 505, the inner end of the first end tube 507 acts on the end of the inner tube 502, the outer end of the first end tube 507 is provided with a first screwing ring 508, the first screwing ring 508 is positioned on the outer end of the extension sleeve 506, a movable tube 510 is screwed in the first end tube 507, the inner end of the movable tube 510 is welded with a plastic hose, the inner end of the plastic hose is provided with a ring groove, the ring groove 512 is arranged in the ring groove, the inner wall of the inner side end of the plastic hose is formed with a conical head 511, the inner side end of the conical head 511 is a small end, the outer side end of the movable tube 510 is provided with a second screwing ring 520, the inner outer side end of the movable tube 510 is screwed with an inner supporting tube 513, the outer wall of the inner side end of the inner supporting tube 513 is formed with a second conical surface 514, the inner side end of the second conical surface 514 is a small end, the outer wall of the second conical surface 514 acts on the conical surface of the conical head 511 so that the sealing ring 512 acts on the inner wall of the inner tube 502, the inner side end of the inner supporting tube 513 is screwed with a filter head, the outer side end of the inner supporting tube 513 is provided with a third screwing ring 515, the inner wall of the outer side end of the third screwing ring 515 is formed with a third conical surface, the inner side end of the third conical surface is a small end, the outer side end of the inner supporting tube 513 is screwed with a second end tube 516, the inner side end wall of the second conical surface 517 is formed with a fourth conical surface 517, the inner side end of the fourth conical surface 517 is a small end, and the conical surface 517 of the fourth conical surface acts on the inner wall of the third conical surface 517, the outer end of the second end tube 516 is provided with a fourth twist ring 518, and the fourth twist ring 518 is provided with a connecting tube head 519.
In this embodiment, end cap 503 at one end is unscrewed during the filling process. The filler is then sucked into the inner tube 502 by means of injection or suction under negative pressure, and the connection tube head 519 on the other end is connected to the suction device while sucking. In operation, the filter head is replaced with a proper specification according to the characteristic of the filler, so the filler is not discharged in the sucking process. And before filling, the position of the filter head at the other end needs to be adjusted according to the height of the filling. When the packing is filled to a certain height, end cap 503 is again attached to outer sleeve 500, and its extended length is adjusted according to the actual condition by rotation of movable tube 510 during operation, and movable tube 510 and inner tube 502 are sealed again by rotation of inner support tube 513 after adjustment, and then chromatography is performed. In the process, the filling column is limited and compacted by the two filter heads, so that the gap in the filling is reduced, and the column efficiency of the filling is improved.
Example 2
This example provides an oscillation device for a chromatographic column as shown in FIG. 1, which is used for fixing the chromatographic column 5 proposed in example 1 and for removing the packing cavities by oscillation. The chromatographic column chromatography column clamping device comprises an oscillating mechanism 1, wherein a mounting frame 2 is arranged on the oscillating mechanism 1, a connecting mechanism 3 is arranged on the mounting frame 2, a clamping mechanism 4 is arranged on the connecting mechanism 3, and the clamping mechanism 4 is used for clamping a chromatographic column 5.
In this embodiment, when eliminating the gap or when carrying out chromatography, the clamping mechanism 4 is used for clamping the chromatographic column 5, then the position of the chromatographic column 5 is adjusted, the oscillating mechanism is started to eliminate the gap after the adjustment, and the height of the filler column is adjusted after the elimination, so that the problem of loose upper end during chromatography is avoided. After completion, the oscillating mechanism 1 cancels the operation and then performs the oscillating operation.
As shown in fig. 2, the oscillating mechanism 1 includes a case 100, one side of the case 100 is opened, one side of the case 100 is connected to a case cover 102 via a hinge 101, and a movable hole 103 is formed in a top cover plate of the case 100.
As shown in fig. 3, a motor mounting plate 104 is mounted on a bottom plate of the box body 100, a motor 105 is mounted on the motor mounting plate 104, an output shaft of the motor 105 is connected with a rotating shaft 106 through a coupling, a pair of shaft seats 107 are arranged on the rotating shaft 106, the shaft seats 107 are mounted on the bottom plate of the box body 100, an eccentric wheel 108 is eccentrically arranged on the rotating shaft 106, two ends of the eccentric wheel 108 are respectively provided with a limiting disc 109, the limiting discs 109 are concentric with the eccentric wheel 108, and a rotating arm 110 is mounted at the other end of the rotating shaft 106.
As shown in fig. 4, a pair of mounting side plates 111 are mounted on the bottom plate of the box body 100, convex guide members 112 are mounted on the inner walls of the mounting side plates 111, movable plates 113 are movably arranged between the convex guide members 112, waist-shaped holes 114 are formed in the movable plates 113, eccentric wheels 108 penetrate through the waist-shaped holes 114, a plurality of concave seats 115 are mounted at two ends of the movable plates 113, the concave seats 115 are sleeved on the convex guide members 112, guide wheels 116 are rotatably arranged at two sides of the concave seats 115, and the peripheral sides of the guide wheels 116 are tangent to the outer walls of the convex guide members 112.
As shown in fig. 5 and 6, the other end of the rotating arm 110 is rotatably provided with a first swing arm 117, the other end of the first swing arm 117 is hinged with a second swing arm 118, the middle part of the second swing arm 118 is rotatably provided with a rotating seat 119, the rotating seat 119 is installed on the side wall of the box body 100, the upper end of the second swing arm 118 is hinged with a connecting plate 120, the other end of the connecting plate 120 is hinged with a boss 121, the root of the boss 121 is provided with a movable side plate 122, the back side of the movable side plate 122 is provided with a guide rail, the guide rail is sleeved with a sliding sleeve 124, the sliding sleeve 124 is provided with an installation seat 125, the installation seat 125 is provided with a movable upper plate 126, the lower wall of the movable upper plate 126 is provided with an installation frame 127, the lower end of the installation frame 127 is provided with an installation frame 128, the lower end of the installation frame 128 is installed on the movable plate 113, the movable side plate 122 is provided with an oscillating plate 123, and the oscillating plate 123 penetrates into the movable hole 103.
As shown in fig. 7 and 8, the mounting frame 2 includes a pair of guide rails 200 mounted on a top cover plate of the box body 100, a sliding sleeve 201 sleeved on the guide rails 200, two ends of the sliding sleeve 201 are respectively provided with an upper extension piece 202, a cavity 203 is formed in an inner wall of the upper extension piece 202, a guide rod 206 is arranged in the cavity 203, a movable seat 205 is movably arranged on the guide rod 206, springs 207 are respectively sleeved on upper and lower ends of the guide rod 206, two sides of the upper extension piece 202 are provided with vertical holes 204, a pair of protruding rods 208 are arranged on the movable seat 205, the protruding rods 208 penetrate through the vertical holes 204, two ends of an oscillating bottom plate 210 are mounted on the movable seat 205 through a plurality of connecting arm plates 209, and the oscillating bottom plate 210 is mounted on the upper end of the oscillating plate 123.
In this embodiment, when the vibration mechanism 1 shakes the filler, the motor 105 is started, the rotating shaft 106 is driven by the motor 105 to rotate, the eccentric wheel 108 is driven to rotate when the rotating shaft 106 rotates, the eccentric wheel 108 swings in the waist-shaped hole 114 when rotating, meanwhile, the movable plate 113 is driven to perform lifting movement, the movable plate 113 drives the vibration plate 123 to perform lifting movement when performing lifting movement, and the vibration bottom plate 210 is driven to perform reciprocating lifting movement on the upper extension piece 202. Meanwhile, the rotation of the rotating shaft 106 drives the rotating arm 110 to rotate, the rotating arm 110 drives the second swing arm 118 to swing around the rotating seat 119 through the first swing arm 117 when rotating, and then drives the movable side plate 122 to move back and forth through the connecting plate 120 through the swing of the second swing arm 118, so that the oscillating plate 123 arranged on the movable side plate moves back and forth at the moment, and in sum, the oscillating plate 123 simultaneously performs back and forth and lifting operations, and the clearance elimination operation is facilitated through the mode.
As shown in fig. 9, an installation base 211 is installed on the oscillation base 210, an upper round rod 212 is installed on the installation base 211, a sleeve seat 213 is sleeved on the upper round rod 212, a locking screw 215 is screwed on the sleeve seat 213, a handle is arranged at the outer side end of the locking screw 215, and a centering rod 214 is arranged between the sleeve seats 213. In actual operation, the locking operation of the locking screw 215 may be canceled first, and then the position height of the socket 213 may be adjusted.
As shown in fig. 10 and 11, the connection mechanism 3 comprises a rectangular sleeve 300 sleeved on a middle rod 214, a concave shell 301 is mounted on the rectangular sleeve 300, a guide block 302 is arranged on the inner wall of the other end of the concave shell 301, a concave frame 303 is mounted at the upper end of the concave shell 301, an upper wire drawing rod 304 is screwed at the upper end of the concave frame 303, a rotating cap 305 is arranged at the upper end of the upper wire drawing rod 304, a movable block 306 is rotatably arranged at the lower end of the upper wire drawing rod 304, a guide groove 307 is formed in the movable block 306, and the guide block 302 penetrates through the guide groove 307. As shown in fig. 12, a pair of corner slots 308 are formed on the inner wall of the movable block 306, the corner slots 308 are in a triangle structure, the vertical surfaces of the corner slots 308 are inclined surfaces, top wheels 309 are tangentially arranged on the inclined surfaces of the corner slots 308, a pair of transverse holes are formed on the concave shell 301, two ends of the top wheels 309 penetrate through the transverse holes, an inner plate 314 is arranged in the concave shell 301, a pair of ejector rods 310 penetrate through the inner plate 314, the outer side ends of the ejector rods 310 are in a hemispherical structure, the outer side ends of the ejector rods 310 are tangentially connected with the outer walls of the top wheels 309, the inner side ends of the ejector rods 310 are in a pointed cone structure, the inner side ends of the ejector rods 310 are connected with inner rings 311 through first pins, second springs 312 are sleeved on the ejector rods 310, the outer side ends of the second springs 312 are provided with outer rings 313, the outer rings 313 are arranged on the outer side ends of the ejector rods 310 through second pins, the inner side ends of the ejector rods 310 penetrate through the rectangular sleeves 300, and the inner side ends of the ejector rods 310 act on the middle rods 214.
When the connecting mechanism 3 fixes the position of the rectangular sleeve 300, an operator can rotate by rotating the cap 305, the rotation of the cap 305 can enable the upper wire drawing rod 304 to pull the movable block 306 to move upwards along the guide groove 307, and when the movable block 306 moves, the inclined surface of the angle groove 308 acts on the top wheel 309, so that the top wheel 309 pushes the top rod 310 to move inwards, the inner side end of the top rod 310 acts on the middle rod 214, and finally the position fixing of the rectangular sleeve 300 is completed.
As shown in fig. 13, the clamping mechanism 4 includes a mounting back plate 400 mounted on the rectangular sleeve 300, and a clamping table 403 is mounted on the mounting back plate 400. As shown in fig. 14, a V-shaped clamping groove 404 is formed at the outer end of the clamping table 403, a pair of side plates 401 are mounted on the mounting backboard 400, a first concave member 402 is rotatably mounted on the side plates 401, a clamping member 409 is mounted on the first concave member 402, a second concave member 405 is rotatably mounted at the lower end of the side plates 401, an inner top screw 406 is screwed on the second concave member 405, a transverse top rod 408 is disposed at the inner end of the inner top screw 406, and a handle rod 407 is disposed at the outer end of the inner top screw 406. As shown in fig. 15, a clamping block 410 is provided on the inner wall of the lower end of the clamping member 409, a clamping inclined wall 411 is formed on the outer wall of the lower end of the clamping member 409, the clamping inclined wall 411 is inclined downward, a V-shaped groove 412 is provided on the upper end of the clamping member 409, the V-shaped groove 412 is located above the clamping inclined wall 411, and when the clamping block 410 acts on the outer wall of the chromatographic column 5, the outer periphery of the lateral ejector rod 408 acts on the clamping inclined wall 411.
When the chromatographic column 5 is clamped by the clamping mechanism, an operator places the chromatographic column 5 on the V-shaped clamping groove 404, then rotates the second concave piece 405 downwards through the handle rod 407, so that the periphery of the transverse ejector rod 408 acts on the clamping inclined wall 411, and then the clamping block 410 acts on the outer wall of the chromatographic column 5, so that the chromatographic column 5 is clamped and fixed through the clamping block 410, and after the completion, the clamping effect of the clamping block 410 on the chromatographic column 5 is further improved through the rotation of the inner ejector rod 406.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the invention, and it will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit and scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (8)
1. The oscillating device for the chromatographic column is characterized by comprising the chromatographic column and an oscillating mechanism (1), wherein the oscillating mechanism (1) is used for eliminating a filler cavity in the chromatographic column;
the chromatographic column comprises an outer sleeve (500), an inner tube (502) is arranged in the outer sleeve (500), and connectors (501) are respectively communicated with two ends of the outer sleeve (500);
the two ends of the outer sleeve (500) are respectively in screwed connection with an end cap (503), the outer side end of the end cap (503) is provided with a sealing ring (504), the sealing ring (504) is positioned between the outer sleeve (500) and the inner tube (502), a first conical surface (505) is formed on the inner side end surface of the sealing ring (504), the inner side end of the first conical surface (505) is a small end, the outer side end of the end cap (503) is provided with an extension sleeve (506), the extension sleeve (506) is internally in screwed connection with a first end tube (507), the inner side end of the first end tube (507) is provided with a conical ring (509), the periphery of the conical ring (509) is of a conical structure, the conical ring (509) penetrates through the first conical surface (505), the inner side end of the first end tube (507) acts on the end part of the inner tube (502), the outer side end of the first end tube (507) is provided with a first screwing ring (508), the first screwing ring (508) is positioned at the outer side end of the extension sleeve (506), the inner side end of the first end tube (507) is in screwed connection with a movable tube (510), the inner side end of the movable tube (510) is welded with a plastic hose, the inner side end of the inner side of the movable tube (510) is provided with a conical ring groove (512), the inner side end of the plastic hose is provided with a conical ring groove (511), the inner side end of the second end of the movable tube (511) is provided with a conical ring groove (520), the inner outer side end of the movable tube (510) is in threaded connection with an inner supporting tube (513), the outer wall of the inner side end of the inner supporting tube (513) is provided with a second conical surface (514), the inner side end of the second conical surface (514) is a small end, the outer wall of the second conical surface (514) acts on the conical surface of the conical head (511) so that the sealing ring (512) acts on the inner wall of the inner tube (502), the inner side end of the inner supporting tube (513) is internally in threaded connection with a filter head, the outer side end of the inner supporting tube (513) is provided with a third screwing ring (515), the inner wall of the outer side end of the third screwing ring (515) is provided with a third conical surface, the inner side end of the third conical surface is a small end, the outer side end of the inner supporting tube (513) is in threaded connection with a second end tube (516), the inner side end of the second conical surface (516) is provided with a fourth conical surface (517), the inner side end of the fourth conical surface (517) acts on the inner wall of the third conical surface, the outer side end of the second end tube (516) is provided with a fourth screwing ring (518), and the fourth screwing ring (519) is provided with a connecting joint;
the oscillating mechanism (1) is provided with a mounting frame (2), the mounting frame (2) is provided with a connecting mechanism (3), the connecting mechanism (3) is provided with a clamping mechanism (4), and the clamping mechanism (4) is used for clamping an outer sleeve (500) on the chromatographic column (5);
the oscillating mechanism (1) comprises a box body (100), a movable hole (103) is formed in a top cover plate of the box body (100), a motor mounting plate (104) is mounted on a bottom plate of the box body (100), a motor (105) is mounted on the motor mounting plate (104), a rotating shaft (106) is connected to an output shaft of the motor (105) through a coupler, an eccentric wheel (108) is eccentrically arranged on the rotating shaft (106), and a rotating arm (110) is mounted at the other end of the rotating shaft (106);
the other end of the rotating arm (110) is rotatably provided with a first swing arm (117), the other end of the first swing arm (117) is hinged with a second swing arm (118), the middle part of the second swing arm (118) is rotatably provided with a rotating seat (119), the rotating seat (119) is arranged on the side wall of the box body (100), the upper end of the second swing arm (118) is hinged with a connecting plate (120), the other end of the connecting plate (120) is hinged with a convex seat (121), the convex seat (121) is connected with an oscillating plate (123) so as to enable the oscillating plate (123) to swing, the lower end of the oscillating plate (123) is also connected with a movable plate (113) capable of lifting, a waist-shaped hole (114) is formed in the movable plate (113), an eccentric wheel (108) penetrates into the waist-shaped hole (114), and the oscillating plate (123) penetrates into the movable hole (103);
the mounting frame (2) comprises a pair of guide rails (200) mounted on a top cover plate of the box body (100), a sliding sleeve (201) is sleeved on the guide rails (200), two ends of the sliding sleeve (201) are respectively provided with an upper extension piece (202), a cavity (203) is formed in the inner wall of the upper extension piece (202), a guide rod (206) is arranged in the cavity (203), a movable seat (205) is movably arranged on the guide rod (206), springs (207) are respectively sleeved at the upper end and the lower end of the guide rod (206), vertical holes (204) are formed in two sides of the upper extension piece (202), a pair of protruding rods (208) are arranged on the movable seat (205), the protruding rods (208) penetrate into the vertical holes (204), and two ends of an oscillating bottom plate (210) are mounted on the movable seat (205) through a plurality of connecting arm plates (209);
the oscillating base plate (210) is installed to oscillating plate (123) upper end, installs on oscillating base plate (210) mounting base (211), installs on mounting base (211) and extends round bar (212), and the cover is equipped with cover seat (213) on extending round bar (212), and the spiro union has locking screw (215) on cover seat (213), and the outside end of locking screw (215) is equipped with the handle, is equipped with a pair of centering rod (214) between cover seat (213).
2. The oscillation device for a chromatography column according to claim 1, wherein the limiting plates (109) are respectively mounted at both ends of the eccentric wheel (108), and the limiting plates (109) are concentric with the eccentric wheel (108).
3. The oscillation device for a chromatographic column according to claim 1, wherein a pair of mounting side plates (111) are mounted on a bottom plate of the case body (100), convex guide members (112) are mounted on inner walls of the mounting side plates (111), movable plates (113) are located between the convex guide members (112), a plurality of concave seats (115) are mounted at both ends of the movable plates (113), the concave seats (115) are sleeved on the convex guide members (112), guide wheels (116) are rotatably arranged at both sides of the concave seats (115), and peripheral sides of the guide wheels (116) are tangent to outer walls of the convex guide members (112).
4. The oscillation device for a chromatographic column according to claim 1, wherein the other end of the connecting plate (120) is hinged with a boss (121), a movable side plate (122) is installed at the root of the boss (121), a guide rail is installed at the back side of the movable side plate (122), the guide rail is transversely arranged, a sliding sleeve (124) is sleeved on the guide rail, a mounting seat (125) is installed on the sliding sleeve (124), a movable upper plate (126) is installed on the mounting seat (125), a mounting frame plate (127) is installed on the lower wall of the movable upper plate (126), a mounting frame (128) is installed at the lower end of the mounting frame plate (127), the lower end of the mounting frame (128) is installed on the movable side plate (113), and the oscillation plate (123) is installed on the movable side plate (122).
5. The oscillation device for a chromatographic column according to claim 1, wherein the connecting mechanism (3) comprises a rectangular sleeve (300) sleeved on the middle rod (214), a concave shell (301) is installed on the rectangular sleeve (300), a guide block (302) is arranged on the inner wall of the other end of the concave shell (301), a concave frame (303) is installed at the upper end of the concave shell (301), a pull-up screw rod (304) is screwed at the upper end of the concave frame (303), a rotating cap (305) is arranged at the upper end of the pull-up screw rod (304), a movable block (306) is rotatably arranged at the lower end of the pull-up screw rod (304), a guide groove (307) is formed in the movable block (306), the guide block (302) penetrates into the guide groove (307), a pair of corner grooves (308) are formed in the inner wall of the movable block (306), the corner grooves (308) are in a triangular structure, a vertical surface of the corner groove (308) is an inclined surface, a top wheel (309) is tangentially arranged on the inclined surface of the corner groove (308), a pair of transverse holes are formed in the concave shell (301), two ends of the top wheel (309) penetrate through the transverse holes, a pair of inner plate (314) are penetrated into the inner plate (301), a hemispherical top wheel (310) is tangentially arranged at the outer side of the inner plate (310), the inner side end of ejector rod (310) has inner ring (311) through first pin connection, and the cover is equipped with second spring (312) on ejector rod (310), and second spring (312) are located the outside of inner panel (314), and the outside end of second spring (312) is equipped with outer loop (313), and outer loop (313) are located on the outside end of ejector rod (310) through the second pin, and the inner side end of ejector rod (310) wears on rectangle cover (300), and the inner side end of ejector rod (310) acts on middle rod (214).
6. The oscillation device for a chromatography column according to claim 5, wherein the inner end of the ejector rod (310) has a pointed cone structure.
7. The oscillation device for a chromatography column according to claim 5, wherein the holding mechanism (4) comprises a mounting back plate (400) mounted on the rectangular sleeve (300), a pair of side plates (401) are mounted on the mounting back plate (400), a first concave member (402) is rotatably mounted on the side plates (401), a holding member (409) is mounted on the first concave member (402), a second concave member (405) is rotatably mounted at the lower end of the side plates (401), an inner top screw rod (406) is screwed on the second concave member (405), a horizontal top rod (408) is arranged at the inner side end of the inner top screw rod (406), a handle rod (407) is arranged at the outer side end of the inner top screw rod (406), a holding block (410) is arranged at the inner wall of the lower end of the holding member, a holding inclined wall (411) is formed at the outer wall of the lower end of the holding member (409), a V-shaped groove (412) is formed at the upper end of the holding member (409), and the V-shaped groove (412) is located above the inclined wall (411), and when the holding block (410) acts on the outer wall of the chromatography column (5), the outer circumference of the top rod (408) acts on the inclined wall.
8. The oscillation device for a chromatographic column according to claim 7, wherein a clamping table (403) is mounted on the mounting backboard (400), a V-shaped clamping groove (404) is formed in the outer side end of the clamping table (403), the clamping block (410) is made of hard rubber, and the inner wall of the clamping block (410) is of a concave arc structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310877816.1A CN116585752B (en) | 2023-07-18 | 2023-07-18 | Chromatographic column and oscillating device for chromatographic column |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310877816.1A CN116585752B (en) | 2023-07-18 | 2023-07-18 | Chromatographic column and oscillating device for chromatographic column |
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| CN116585752B true CN116585752B (en) | 2023-10-20 |
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| CN117723690B (en) * | 2024-02-01 | 2024-04-19 | 广州恒广复合材料有限公司 | Polyquaternium-51 detection equipment and detection method thereof |
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