CN206583869U - A kind of chromatographic column with adapter - Google Patents
A kind of chromatographic column with adapter Download PDFInfo
- Publication number
- CN206583869U CN206583869U CN201621061939.XU CN201621061939U CN206583869U CN 206583869 U CN206583869 U CN 206583869U CN 201621061939 U CN201621061939 U CN 201621061939U CN 206583869 U CN206583869 U CN 206583869U
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- CN
- China
- Prior art keywords
- pipe
- seal
- adjustable pipe
- nipple
- chromatographic column
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The utility model discloses a kind of chromatographic column with adapter, including chromatography vial wall, the chromatographic column tube wall top is provided with column cap block, and the chromatography vial wall bottom is provided with lower end cap, the lower end cap is provided with lower film in chromatography vial wall；The thick plastic flexible pipe is fixedly connected with extra heavy pipe seal nipple, and the extra heavy pipe seal nipple head end is provided with the first nipple, and the extra heavy pipe seal nipple is connected by the first nipple with threaded sleeve one end；The threaded sleeve other end is connected by the second nipple with tubule seal nipple, and the tubule seal nipple is fixedly connected with thin plastic flexible pipe.The utility model can not only improve the sealing of chromatographic column, improve separating-purifying effect, and the height of adjustable pipe can be adjusted in time according to pressure in liquid level in chromatographic column and chromatographic column, the plastic flexible pipe for causing caliber different simultaneously is sealedly connected, and solves the connectivity problem of different pressures, different tube diameters.
Description
Technical field
The utility model is related to a kind of chromatographic column of bio-separation purifying, more particularly, to a kind of layer with adapter
Analyse post.
Background technology
Chromatographic column is the main body in gel chromatography technology, general to use glass tube or lucite tube.According to sample mixture
Middle each component is different with distribution coefficient in mobile phase in stationary phase, so that a kind of chromatography of separation.Chromatographic column is in biological products
Had a wide range of applications in isolating and purifying.At present, simple in construction, cheap chromatographic column sealing is not fine, it may occur that
The phenomenon of leakage；Existing chromatographic column is when carrying out sample separating-purifying, and poor sealing, chromatographic column content is also easy to produce bubble, shadow
Ring separating effect；In chromatographic column and auto injection instrument pipeline connection procedure, because connector caliber is different, it is under pressure big
Small difference, thus the connectivity problem of different tube diameters must be solved.
Utility model content
The purpose of this utility model is that there is provided a kind of chromatographic column with adapter.It can not only improve chromatographic column
Sealing, improves separating-purifying effect, and can adjust work in time according to pressure in liquid level in chromatographic column and chromatographic column
The height of dynamic pipe, while so that the different plastic flexible pipe of caliber is sealedly connected, solving the company of different pressures, different tube diameters
Connect problem.
The technical solution of the utility model：A kind of chromatographic column with adapter, including chromatography vial wall, the chromatographic column
Tube wall top is provided with column cap block, and the chromatography vial wall bottom is provided with lower end cap, the lower end cap in chromatography vial wall
Provided with lower film；The adjustable pipe of column cap block is provided through in the chromatography vial wall, the activity pipe outer wall is provided with movable pipe sleeve
Pipe, is provided with sealing gasket between the adjustable pipe sleeve pipe and column cap block；The head end of adjustable pipe in the insertion chromatography vial wall
Provided with seal head, the seal head and chromatography vial wall inwall junction be sequentially provided with the first sealing gasket from top to bottom, second close
Packing and the 3rd sealing gasket；The adjustable pipe is fixed through seal head and with adjustable pipe head end seal；The adjustable pipe passes through
Bobbin seal joint is connected with thick plastic flexible pipe；The thick plastic flexible pipe is fixedly connected with extra heavy pipe seal nipple, and the extra heavy pipe is close
Sealing joint head end is provided with the first nipple, and the extra heavy pipe seal nipple is connected by the first nipple and threaded sleeve one end
Connect；The threaded sleeve other end is connected by the second nipple with tubule seal nipple, the tubule seal nipple with it is thin
Plastic flexible pipe is fixedly connected.
Using this structure, the seal head is sequentially provided with the first sealing from top to bottom with chromatography vial wall inwall junction
Pad, the second sealing gasket and the 3rd sealing gasket, the setting of three-layer sealed pad, can effectively improve seal head and chromatography vial wall junction
Sealing；When the chromatographic column with adapter is carrying out sample separating-purifying, the sealing of chromatographic column can be improved so that layer
Separating liquid is not allowed to be also easy to produce bubble in analysis post, improves separating-purifying effect；The utility model carries the chromatographic column of adapter, in layer
Analyse in post and auto injection instrument pipeline connection procedure so that the different plastic flexible pipe of caliber is sealedly connected, and solves not
The connectivity problem of same pressure, different tube diameters.
As the preferred embodiment of above-mentioned technical proposal, it is a kind of with adapter that the utility model embodiment is provided
Chromatographic column further comprises the part or all of of following technical characteristic：
As the improvement of above-mentioned technical proposal, in one embodiment of the present utility model, the adjustable pipe sleeve pipe and work
Dynamic pipe is flexibly connected.
Using this structure, adjustable pipe sleeve pipe is flexibly connected with adjustable pipe, adjustable pipe can in adjustable pipe sleeve pipe on move down
It is dynamic, so as to adjust the height of adjustable pipe in time according to pressure in liquid level in chromatographic column and chromatographic column.
As the improvement of above-mentioned technical proposal, in one embodiment of the present utility model, the adjustable pipe sleeve pipe and work
Dynamic pipe junction is provided with adjustable pipe seal head on the top of adjustable pipe sleeve pipe.
Using this structure, the sealing of adjustable pipe sleeve pipe and adjustable pipe junction can be improved, so as to improve on the whole
The sealing of chromatographic column.
As the improvement of above-mentioned technical proposal, in one embodiment of the present utility model, the adjustable pipe head end sealing
End face of the part towards lower end cap direction is in curved surface.
Using this structure, end face of the adjustable pipe head end seal towards lower end cap direction is in curved surface, can reduce adjustable pipe
The contact area of head end seal and liquid in chromatographic column, it is to avoid liquid is contaminated in chromatographic column.
As the improvement of above-mentioned technical proposal, in one embodiment of the present utility model, the lower film is using high pressure resistant
The ultrahigh molecular weight polyethylene of hydrophilic nontoxic high-purity pharmaceutical grade into.
Described above is only the general introduction of technical solutions of the utility model, in order to better understand skill of the present utility model
Art means, and being practiced according to the content of specification, and in order to allow above and other purpose of the present utility model, feature
It can be become apparent with advantage, below in conjunction with preferred embodiment, and coordinate accompanying drawing, describe in detail as follows.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model；
Fig. 2 is the mplifying structure schematic diagram at A in Fig. 1 of the present utility model.
Mark in accompanying drawing for：1- chromatographs vial wall, 2- column cap blocks, 3- adjustable pipes, 4- sealing gaskets, 5- movable pipe sleeves
Pipe, 6- seal heads, the sealing gaskets of 7- first, the sealing gaskets of 8- the 3rd, the sealing gaskets of 9- second, 10- adjustable pipe seal heads, 11- lower films,
12- lower end caps, 13- adjustable pipe head end seals, the thick plastic flexible pipes of 14-, 15- bobbin seal joints, 16- extra heavy pipe seal nipples,
The nipples of 17- first, 18- threaded sleeves, 19- tubule seal nipples, the nipples of 20- second, the thin plastic flexible pipes of 21-.
Embodiment
The utility model is further described with reference to the accompanying drawings and examples, but is not intended as to the utility model
The foundation of limitation.
Embodiment.A kind of chromatographic column with adapter, is constituted as shown in Figure 1-2, including chromatography vial wall 1, the layer
Analyse the top of vial wall 1 and be provided with column cap block 2, chromatography vial wall 1 bottom is provided with lower end cap 12, the lower end cap 12 in layer
Analyse and lower film 11 is provided with vial wall 1；The adjustable pipe 3 of column cap block 2, the adjustable pipe 3 are provided through in the chromatography vial wall 1
Outer wall is provided with adjustable pipe sleeve pipe 5, and sealing gasket 4 is provided between the adjustable pipe sleeve pipe 5 and column cap block 2；The insertion chromatographic column
The head end of adjustable pipe 3 in tube wall 1 is provided with seal head 6, and the seal head 6 is with chromatographing the inwall junction of vial wall 1 from top to bottom
It is sequentially provided with the first sealing gasket 7, the second sealing gasket 9 and the 3rd sealing gasket 8；The adjustable pipe 3 is through seal head 6 and uses adjustable pipe
Head end seal 13 is fixed；The adjustable pipe 3 is connected by bobbin seal joint 15 with thick plastic flexible pipe 14；The thick plastics are soft
Pipe 14 is fixedly connected with extra heavy pipe seal nipple 16, and the head end of extra heavy pipe seal nipple 16 is provided with the first nipple 17, described thick
Seal of tube joint 16 is connected by the first nipple 17 with the one end of threaded sleeve 18；The other end of threaded sleeve 18 passes through
Two nipples 20 are connected with tubule seal nipple 19, and the tubule seal nipple 19 is fixedly connected with thin plastic flexible pipe 21.
The adjustable pipe sleeve pipe 5 is flexibly connected with adjustable pipe 3.The adjustable pipe sleeve pipe 5 is with the junction of adjustable pipe 3 in activity
The top of pipe-in-pipe 5 is provided with adjustable pipe seal head 10.
End face of the adjustable pipe head end seal 13 towards the direction of lower end cap 12 is in curved surface.The lower film 11 uses resistance to height
Press the ultrahigh molecular weight polyethylene of hydrophilic nontoxic high-purity pharmaceutical grade into.
Adjustable pipe 3 is passed through bobbin seal joint 15 and thick modeling by the utility model when carrying out bioproduct separation purifying
Material flexible pipe 14 is connected, and thick plastic flexible pipe 14 is fixedly connected with extra heavy pipe seal nipple 16, passes through the head end of extra heavy pipe seal nipple 16
The first nipple 17 being provided with, thick plastic flexible pipe 14 and threaded sleeve 18 are connected；Thin plastic flexible pipe 21 and tubule are close
Sealing joint 19 is fixedly connected, the second nipple 20 being provided with by the head end of tubule seal nipple 19, by thin plastic flexible pipe 21 with
Threaded sleeve 18 is connected, and realizes the connection of different tube diameters pipeline, and entering sampling instrument with outside by thin plastic flexible pipe 21 is connected
Get up, sample introduction is carried out by adjustable pipe 3, lower end cap 12 is connected by plastic tube with collected outside device, collect separation
Liquid after purification, so as to form the system of a circulation, reaches and isolates and purifies purpose.
Adjustable pipe sleeve pipe 5 is flexibly connected with adjustable pipe 3, and adjustable pipe 3 can be moved up and down in adjustable pipe sleeve pipe 5, so as to
Adjust the height of adjustable pipe in time according to pressure in liquid level in chromatographic column and chromatographic column.
It is close that the seal head 6 is sequentially provided with the first sealing gasket 7, second from top to bottom with chromatography vial wall 1 inwall junction
The sealing gasket 8 of packing 9 and the 3rd, the setting of three-layer sealed pad can effectively improve seal head 6 with chromatographing the close of the junction of vial wall 1
Feng Xing.
Described above is preferred embodiment of the present utility model, can not be limited certainly with this utility model it
Interest field, it is noted that for those skilled in the art, before the utility model principle is not departed from
Put, some improvement and variation can also be made, these are improved and variation is also considered as protection domain of the present utility model.
Claims (1)
1. a kind of chromatographic column with adapter, it is characterised in that：Including chromatography vial wall (1), chromatography vial wall (1) top
End is provided with column cap block (2), and described chromatography vial wall (1) bottom is provided with lower end cap (12), the lower end cap (12) in chromatography
Lower film (11) is provided with vial wall (1)；The adjustable pipe (3) of column cap block (2), institute are provided through in the chromatography vial wall (1)
Adjustable pipe (3) outer wall is stated provided with adjustable pipe sleeve pipe (5), sealing gasket is provided between the adjustable pipe sleeve pipe (5) and column cap block (2)
(4)；The head end of adjustable pipe (3) in insertion chromatography vial wall (1) is provided with seal head (6), the seal head (6) and chromatography column jecket
Wall (1) inwall junction is sequentially provided with the first sealing gasket (7), the second sealing gasket (9) and the 3rd sealing gasket (8) from top to bottom；Institute
State adjustable pipe (3) through seal head (6) and fixed with adjustable pipe head end seal (13)；The adjustable pipe (3) is close by sleeve pipe
Sealing joint (15) is connected with thick plastic flexible pipe (14)；The thick plastic flexible pipe (14) is fixedly connected with extra heavy pipe seal nipple (16),
Extra heavy pipe seal nipple (16) head end is provided with the first nipple (17), and the extra heavy pipe seal nipple (16) passes through the first screw thread
Joint (17) is connected with threaded sleeve (18) one end；Threaded sleeve (18) other end is by the second nipple (20) and carefully
Seal of tube joint (19) is connected, and the tubule seal nipple (19) is fixedly connected with thin plastic flexible pipe (21)；
The adjustable pipe sleeve pipe (5) is flexibly connected with adjustable pipe (3)；
The adjustable pipe sleeve pipe (5) is provided with adjustable pipe seal head with adjustable pipe (3) junction on the top of adjustable pipe sleeve pipe (5)
(10)；
End face of the adjustable pipe head end seal (13) towards lower end cap (12) direction is in curved surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621061939.XU CN206583869U (en) | 2016-09-18 | 2016-09-18 | A kind of chromatographic column with adapter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621061939.XU CN206583869U (en) | 2016-09-18 | 2016-09-18 | A kind of chromatographic column with adapter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206583869U true CN206583869U (en) | 2017-10-24 |
Family
ID=60108658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621061939.XU Expired - Fee Related CN206583869U (en) | 2016-09-18 | 2016-09-18 | A kind of chromatographic column with adapter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206583869U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116585752A (en) * | 2023-07-18 | 2023-08-15 | 成都百泉生物医药科技有限公司 | Chromatographic column and oscillating device for chromatographic column |
-
2016
- 2016-09-18 CN CN201621061939.XU patent/CN206583869U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116585752A (en) * | 2023-07-18 | 2023-08-15 | 成都百泉生物医药科技有限公司 | Chromatographic column and oscillating device for chromatographic column |
| CN116585752B (en) * | 2023-07-18 | 2023-10-20 | 成都百泉生物医药科技有限公司 | Chromatographic column and oscillating device for chromatographic column |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171024 Termination date: 20180918 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |