CN218853701U

CN218853701U - Downward-pressing filtering type purifying column

Info

Publication number: CN218853701U
Application number: CN202222963192.9U
Authority: CN
Inventors: 李晋成; 周锐东; 刘欢; 孙慧武
Original assignee: Chinese Academy Of Fishery Science
Current assignee: Chinese Academy Of Fishery Science
Priority date: 2022-11-08
Filing date: 2022-11-08
Publication date: 2023-04-14
Anticipated expiration: 2032-11-08

Abstract

The utility model relates to a type of filtering purifies post pushes down, include: the liquid storage pipe is used for accommodating a sample extracting solution to be purified; the upper end of the hollow column tube is an open end, and the lower end of the hollow column tube is a closed end; the liquid inlet pipe is integrally connected with the closed end of the hollow column pipe, and the liquid inlet pipe is communicated with the inner cavity of the hollow column pipe; the purification component is arranged in the hollow column tube close to the closed end of the hollow column tube and is suitable for adsorbing impurities in the sample extracting solution flowing from the liquid inlet tube; and the piston piece is arranged on the hollow column tube, can be inserted into the liquid storage tube and forms a sliding sealing structure with the liquid storage tube. The utility model discloses when using, treat to purify the manual empty column pipe that compresses down of sample extract accessible and realize one step of filtration edulcoration through purifying the filler, can realize directly going up the appearance, need not to use solid phase extraction device, improved work efficiency, and have simple structure, set up reasonable, convenient to use, cost of manufacture low grade advantage.

Description

Downward-pressing filtering type purifying column

Technical Field

The utility model relates to a purifier, concretely relates to type of filtering purification post pushes down belongs to solid-phase extraction technical field.

Background

The QuEChERS (Quick, easy, cheap, effective, rugged, safe) technology is a rapid sample pretreatment technology for food detection of grains, vegetables and the like which is developed internationally in recent years, is developed by American Ministry of agriculture, professor Anastasiades equal to 2003, is already widely used in the field of food detection at present, and has relevant detection standards in the United states, european Union and China.

The purification step of the QuEChERS technology mainly comprises two steps of purifying an extracting solution by adopting dispersed solid phase extraction and purification filler and concentrating and redissolving. However, in the purification step based on the QuEChERS sample pretreatment technology, acetonitrile, a matrix to be detected and a purification filler are generally mixed and violently vibrated, and then the mixture is placed in a centrifuge and centrifuged to obtain an upper layer extract, so that the operation is complicated.

SUMMERY OF THE UTILITY MODEL

The utility model discloses aim at solving one of the technical problem that exists among the prior art at least. Therefore, the utility model provides a simple structure, reasonable in design, convenient to use's a type of pushing down filters purification post waits to purify the manual purification post that pushes down of sample extract accessible and realizes the edulcoration through purifying the packing layer, has improved work efficiency.

In order to achieve the purpose, the utility model adopts the following technical proposal: a down-pressure filtration purification column comprising: the liquid storage pipe is used for accommodating a sample extracting solution to be purified; the upper end of the hollow column tube is an open end, and the lower end of the hollow column tube is a closed end; the liquid inlet pipe is integrally connected to the closed end of the hollow column pipe, and the liquid inlet pipe is communicated with the inner cavity of the hollow column pipe; the purification component is arranged in the hollow column tube close to the closed end of the hollow column tube and is suitable for adsorbing impurities in the sample extracting solution flowing from the liquid inlet tube; the piston piece is arranged on the hollow column tube, and the piston piece can be inserted into the liquid storage tube and forms a sliding sealing structure between the liquid storage tubes.

The filter-down purification column preferably comprises: at least one pair of porous sieve plates are fixed in the hollow column pipe at intervals; and the purification filler is filled between the porous sieve plates arranged in pairs.

Preferably, the piston member is a rubber plug fixed to the outer portion of the closed end of the hollow column tube, and the rubber plug is provided with a through hole through which the liquid inlet tube penetrates.

Preferably, the piston member is a sealing ring fixed to the hollow column tube.

The downward-pressing filter type purification column is preferably provided with a sealing cover at the open end of the hollow column tube.

Preferably, the pipe wall near the open end of the hollow column pipe is provided with an exhaust hole, and the exhaust hole is used for communicating the inner cavity of the hollow column pipe with the outside.

Preferably, the closed end of the hollow column tube is downward formed with a conical recess, and the liquid inlet tube is integrally connected to the central position of the conical recess.

Preferably, the purification packing is QuECHERS purification packing with different specifications.

Preferably, the purification filler is a mixture of anhydrous magnesium sulfate, ethylenediamine-N-propyl silanized silica gel filler and graphitized carbon black.

The utility model discloses owing to take above technical scheme, it has following advantage:

the utility model provides a type of filtering purifies post pushes down, treat to purify the manual empty column pipe that pushes down of sample extract accessible and realize one step of filtration edulcoration through purifying the filler, can realize directly getting on the appearance, need not to use the solid phase extraction device, improved work efficiency, and have simple structure, set up reasonable, convenient to use, cost of manufacture low grade advantage.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive exercise.

Fig. 1 is a schematic sectional view of a downward-pressure filtration type purification column provided in embodiment 1 of the present invention;

fig. 2 is a schematic cross-sectional view of a downward-pressure filtration type purification column provided in embodiment 2 of the present invention;

fig. 3 is a schematic cross-sectional view of a downward-pressure filtration-type purification column provided in embodiment 3 of the present invention;

fig. 4 is a schematic cross-sectional view of a downward-pressure filtration-type purification column provided in embodiment 4 of the present invention.

The various reference numbers in the figures:

1-a liquid storage pipe; 2-empty column tube; 3-a liquid inlet pipe; 4-a purification component; 5-a piston member; 21-exhaust hole; 22-a sealing cover; 23-a sealing ring; 41-porous sieve plate; 42-purifying the filler.

Detailed Description

To make the objects, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings. It is to be understood that the embodiments described are only some of the embodiments of the present invention, and not all of them. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "upper", "lower", "front", "rear", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the system or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "assembled", "disposed" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.

The utility model provides a type purifying column is filtered to push down formula, include: the liquid storage tube is used for accommodating a sample extracting solution to be purified; the upper end of the hollow column tube is an open end, and the lower end of the hollow column tube is a closed end; the liquid inlet pipe is integrally connected with the closed end of the hollow column pipe, and the liquid inlet pipe is communicated with the inner cavity of the hollow column pipe; the purification component is arranged in the hollow column tube close to the closed end of the hollow column tube and is suitable for adsorbing impurities in the sample extracting solution flowing from the liquid inlet tube; and the piston piece is arranged on the hollow column tube, can be inserted into the liquid storage tube and forms a sliding sealing structure with the liquid storage tube. The utility model discloses when using, treat to purify the manual empty column pipe that compresses down of sample extract accessible and realize one step of filtration edulcoration through purifying the filler, can realize directly going up the appearance, need not to use solid phase extraction device, improved work efficiency, and have simple structure, set up reasonable, convenient to use, cost of manufacture low grade advantage.

The following describes a down-flow filter column according to an embodiment of the present invention in detail with reference to the accompanying drawings.

Example 1:

as shown in fig. 1, the downward-pressure filtration type purification column provided in this embodiment includes: the liquid storage tube 1 is used for containing a sample extracting solution to be purified; the upper end of the hollow column tube 2 is an open end, and the lower end of the hollow column tube 2 is a closed end; the liquid inlet pipe 3 is integrally connected to the closed end of the hollow column pipe 2, and the liquid inlet pipe 3 is communicated with the inner cavity of the hollow column pipe 2; the purification component 4 is arranged inside the hollow column tube 2 close to the closed end of the hollow column tube 1, and the purification component 4 is suitable for adsorbing impurities in the sample extracting solution flowing from the liquid inlet tube 3; the rubber plug 5 is fixed outside the closed end of the hollow column tube 2, a through hole for the liquid inlet tube 3 to penetrate out is formed in the rubber plug 5, and the rubber plug 5 can be inserted into the liquid storage tube 1 and forms a sliding sealing structure with the liquid storage tube 1.

In the above embodiment, preferably, the purification assembly 4 includes: at least one pair of porous sieve plates 41 are fixed in the hollow column tube 2 at intervals; and a purification filler 42 filled between the pair of porous sieve plates 41.

In the above embodiment, preferably, the tube wall near the open end of the hollow column tube 2 is provided with the vent hole 21, and the vent hole 21 is used for communicating the inner cavity of the hollow column tube 2 with the outside so as to adjust the pressure in the hollow column tube 2.

In the above embodiment, preferably, the closed end of the hollow column tube 2 is formed downward into a conical recess, and the liquid inlet tube 3 is integrally connected to the central position of the conical recess.

In the above embodiment, the purifying filler 42 is preferably QuECHERS purifying filler with different specifications, such as anhydrous magnesium sulfate, a mixture of ethylenediamine-N-propyl silanized silica gel filler (PSA) and Graphitized Carbon Black (GCB) recommended in gas chromatography-mass spectrometry combined method for measuring the residual amount of 208 pesticides and their metabolites in plant-derived food in national standard for food safety, and the like.

When the downward-pressing filtering type purifying column provided by the embodiment is used, the specific operation steps are as follows:

1. sleeving a rubber plug 5 at the closed end of the hollow column tube 2 through a liquid inlet tube 3;

2. adding a mixture of anhydrous magnesium sulfate, PSA and GCB or a QuECHERS purification filler consisting of the same into the hollow column tube 2, and respectively arranging a porous sieve plate 41 at the upper part and the lower part of the purification filler 42;

3. loading: inserting a rubber plug 5 into a liquid storage pipe 1 filled with a sample extracting solution to be purified, sealing the open end of an empty column pipe 2, then pushing the empty column pipe 2 downwards, pressing the sample extracting solution to be purified into the empty column pipe 2 through a liquid inlet pipe 3 under the pressure action of downward pushing of a piston piece 5, and enabling the sample extracting solution to be purified to sequentially pass through a porous sieve plate 41 and a purifying filler 42, wherein the purifying filler 42 adsorbs impurities in the sample extracting solution;

4. solid-liquid separation: and directly transferring the purified sample extracting solution in the hollow column tube 2 into a sample bottle, and performing instrument analysis such as liquid chromatography-tandem mass spectrometry.

Example 2:

as shown in fig. 2, this embodiment is different from embodiment 1 in that the open end of the hollow cylindrical tube 2 is not sealed when the hollow cylindrical tube 2 placed in the liquid storage tube 1 is pressed down, and the upper side wall of the hollow cylindrical tube 3 is not provided with the air vent 21.

Example 3:

as shown in fig. 3, the present embodiment is different from embodiment 1 in that a sealing cover 22 is provided at an open end of an empty cylinder 2 placed in a liquid storage tube 1 when the empty cylinder 2 is pressed down to prevent liquid from splashing.

Example 4:

as shown in fig. 4, the present embodiment is different from embodiment 3 in that, when the hollow column tube 2 in the liquid storage tube 1 is pressed down, a sealing ring 23 may be disposed on the outer circumference of the hollow column tube 2, and at this time, the rubber plug 5 at the bottom may be replaced, and the liquid may be prevented from splashing.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention in its corresponding aspects.

Claims

1. A push down filter purification column comprising:

the liquid storage pipe is used for accommodating a sample extracting solution to be purified;

the upper end of the hollow column tube is an open end, and the lower end of the hollow column tube is a closed end;

the liquid inlet pipe is integrally connected to the closed end of the hollow column pipe, and the liquid inlet pipe is communicated with the inner cavity of the hollow column pipe;

the purification component is arranged in the hollow column tube close to the closed end of the hollow column tube and is suitable for adsorbing impurities in the sample extracting solution flowing from the liquid inlet tube;

the piston piece is arranged on the hollow column tube, and the piston piece can be inserted into the liquid storage tube and forms a sliding sealing structure between the liquid storage tubes.

2. The push down filter purification column of claim 1, wherein the purification assembly comprises:

at least one pair of porous sieve plates are fixed in the hollow column pipe at intervals;

and the purification filler is filled between the porous sieve plates arranged in pairs.

3. The downward-pressing filter type purification column according to claim 1, wherein the piston member is a rubber plug fixed to the outside of the closed end of the hollow column tube, and the rubber plug is provided with a through hole for the liquid inlet tube to pass through.

4. The filter down-pressure purification column of claim 1, wherein the piston member is a sealing ring secured to the hollow column tube.

5. The push down filter purification column of claim 1, wherein a sealing cap is provided at the open end of the hollow column tube.

6. The downward-pressure filter type purification column as claimed in claim 5, wherein a gas vent is provided on the wall of the column tube near the open end of the column tube, the gas vent being used to connect the inner cavity of the column tube with the outside.

7. The downward-pressure filter type purification column according to claim 1, wherein the closed end of the hollow column tube is formed with a tapered recess downward, and the liquid inlet tube is integrally connected to a central position of the tapered recess.

8. The push down filter purification column of claim 2, wherein the purification packing is QuECHERS purification packing of different specifications.