CN218630340U - Object carrying platform for portable micro scanner - Google Patents

Abstract

The utility model provides a loading platform for portable micro-scanner, the base is fixedly connected with the z-axis seat, the top of the base is provided with a groove in the x direction, the x-direction seat is arranged in the groove in the x direction, the base is provided with an x-axis motor seat extending to one side in the y direction, the x-axis motor seat is used for being fixedly connected with an x-axis stepping motor, one side of the x-direction seat is provided with an extending x arm, a nut is fixedly arranged on the x arm, the x-axis stepping motor is fixedly connected with an x-axis screw rod, and the x-axis screw rod is in threaded connection with the nut; be equipped with y to the recess at x to the top of seat, y sets up in y to the recess to the seat, is equipped with the y axle motor cabinet to one side extension to x to the seat at x, y axle motor cabinet and y axle step motor fixed connection, is equipped with the y arm of extension to one side that the seat corresponds at y, has set firmly the nut on the y arm, y axle step motor and y axle screw rod fixed connection, y axle screw rod and nut threaded connection. The utility model discloses simplify the structure of objective table, and be convenient for improve walking speed.

Description

Object carrying platform for portable micro scanner

Technical Field

The utility model relates to a microscopic image gathers the field, especially a cargo platform for portable micro scanner.

Background

The cell and tissue pathology image identification technology is considered as an authoritative and definite diagnosis means, but the cell and tissue pathology image identification technology has a long detection process, and comprises the processes of sampling, sheet making, sample microscopic image acquisition, image splicing, image identification and the like. In the fully artificial age, only one single-digit diagnosis can be completed by one pathologist a day. This is far from satisfying the user's needs. The existing diagnostic procedure has a bottleneck that the equipment for microscopic image scanning is expensive and time-consuming. In foreign technology, dr, weinstein, in cooperation with D Metrix research and development team in the united states, developed a set of pathological diagnosis product rapid digital slice micro-scanner DX-40. The scheme of integrating 80 microscopes for scanning simultaneously can realize the processing speed of 40 sheets per hour. But the structure is very complicated, resulting in high price. The applicant has previously developed a series of miniature microscopic image acquisition devices, such as those described in CN110794569A cell miniature microscopic image acquisition devices and image recognition methods. The mobile phone is used as the image acquisition equipment, so that the cost of the equipment is greatly reduced. However, the structure of the loading platform of the device is still complex, which is not beneficial to reducing the volume of the whole device, and the occupied space of the equipment is larger when the array type scanning center is arranged.

SUMMERY OF THE UTILITY MODEL

The utility model aims to solve the technical problem that a cargo platform for portable micro-scanner is provided, can make micro-scanner have compacter structure to constitute the cluster with more micro-scanner, improve scanning efficiency.

In order to solve the technical problem, the utility model discloses the technical scheme who adopts is: an object carrying platform for a portable micro scanner comprises a base, a z-axis seat, an x-axis seat and a y-axis seat;

the X-axis stepping motor is fixedly connected with an X-axis screw rod, and the X-axis screw rod is in threaded connection with a nut;

be equipped with y to the recess at x to the top of seat, y sets up in y to the recess to the seat to slide along y, be equipped with to x to the seat to the y axle motor cabinet of one side extension at x, y axle motor cabinet and y axle step motor fixed connection, be equipped with the y arm of extension to one side that corresponds at y to the seat, the nut has set firmly on the y arm, y axle step motor and y axle screw rod fixed connection, y axle screw rod and nut threaded connection.

In a preferable scheme, a groove body facing to the outer side is arranged at the top of the y-direction seat, and the slide frame is arranged in the groove body.

In a preferable scheme, a plurality of screw holes are formed in the x-direction seat and the y-direction seat, and the lubricating block is fixedly connected with the screw holes through screws so as to lubricate among the base, the x-direction seat and the y-direction seat.

In the preferred scheme, the base, the z-axis seat, the x-axis seat and the y-axis seat are made of aluminum alloy materials.

In the preferred scheme, an x-axis stroke sensor is arranged between an x-axis motor base and an x-axis arm and used for verifying the relative displacement between stroboflash and a base in the x direction;

a y-axis stroke sensor is arranged between the y-axis motor base and the y arm and used for verifying the relative displacement between stroboflash and the x-direction base;

the x-axis stroke sensor and the y-axis stroke sensor adopt laser displacement sensors.

In the preferred scheme, the z shaft seat is connected with a lens barrel seat, the lens barrel seat is provided with a vertical through hole, one side of the lens barrel seat is provided with a slit opening, the microscope lens barrel and the industrial camera are arranged in the vertical through hole, and a screw penetrating through the slit opening is arranged at the position of the slit opening.

In the preferred scheme, the shaft seat is connected with the lens barrel seat in a sliding manner, a z-axis stepping motor is further arranged on the z-axis seat, a screw hole is formed in the lens barrel seat, the z-axis stepping motor is fixedly connected with a z-axis screw rod, the z-axis screw rod is in threaded connection with the screw hole, and the z-axis stepping motor is used for finely adjusting the focus of the lens barrel seat.

In the preferred scheme, the microscope tube is coaxial or one side still is equipped with the stroboscopic head, and the stroboscopic head is used for according to the continuous travel of step-by-step objective table, sends the flash of light according to the frequency of setting for, and the flash of light frequency that industry camera followed the stroboscopic head carries out image acquisition.

In a preferred scheme, one side of the microscope tube is also provided with an optical compensation sensor.

In a preferred scheme, a panoramic lens is further arranged on one side of the microscope tube, and the field of view of the panoramic lens covers the whole slide frame or slide.

The utility model provides a pair of a cargo platform for portable micro-scanner compares with prior art, has following beneficial effect:

1. the utility model discloses a scheme that has the guide holder of self-steering and self-driven structure has simplified the structure of objective table by a wide margin, and is convenient for improve walking speed.

2. By using the continuous walking + stroboscopic scheme, a smaller numerical aperture can be used in the microscope tube. Therefore, the acquired image has a deeper view field, the diffraction limit image precision is improved, and the edge deformation and the chromatic dispersion are smaller.

3. The light compensation sensor that sets up can realize the luminance between each field of vision unified through luminance compensation in the later stage to the technological problem that stroboscopic working method newly produced has been overcome.

4. The utility model discloses a prior art's ripe component carries out optimal design and accurate control, has reduced equipment cost by a wide margin, more does benefit to the micro-scanner and promotes at basic unit's medical institution to benefit to more users, will be for example malignant tumor such as cervical carcinoma intercepts at the initial stage, improves the cure rate of tumour by a wide margin.

Drawings

The invention will be further described with reference to the following drawings and examples:

fig. 1 is a perspective view of the objective table support of the present invention.

Fig. 2 is a schematic view of the overall structure of the present invention.

Fig. 3 is a schematic view of the field of view and path of the present invention.

Fig. 4 is a schematic structural view of the stroboscopic head of the present invention.

Fig. 5 is a schematic view of the slide structure of the present invention.

In the figure: the device comprises a display device 1, an industrial personal computer 2, a controller 3, a memory 4, a z-axis seat 5, a z-axis stepping motor 6, a z-axis screw 7, a z-axis sliding chute 8, a lens barrel seat 9, a microscope tube 10, an optical compensation sensor 11, a panoramic lens 12, a slide frame 13, a y-axis seat 14, an x-axis seat 15, an x-arm 16, a y-axis motor seat 17, a y-axis stepping motor 18, a y-axis screw 19, a y-arm 20, a y-axis stroke sensor 21, an x-axis motor seat 22, an x-axis stroke sensor 23, an x-axis stepping motor 24, an x-axis screw 25, a base 26, a switch element 27, a switch control signal 28, a power supply 29, a coded image 30, a slide 31, a tissue sample 32, an industrial camera 33, a stroboscopic head 34, an LED light source 35, a slit opening 36, a visual field 100 and a scanning path 200.

Detailed Description

Example 1:

as shown in fig. 1 to 2, a carrier platform for a portable micro scanner includes a base 26, a z-axis seat 5, an x-axis seat 15, and a y-axis seat 14;

the base 26 is fixedly connected with the z-axis seat 5, the top of the base 26 is provided with an x-direction groove, the x-direction seat 15 is arranged in the x-direction groove and slides along the x direction, the base 26 is provided with an x-axis motor seat 22 extending towards one side of the y direction, the x-axis motor seat 22 is used for being fixedly connected with an x-axis stepping motor 24, one side, corresponding to the x-direction seat 15, of the x-axis motor seat is provided with an extending x-arm 16, the x-arm 16 is fixedly provided with a nut, the x-axis stepping motor 24 is fixedly connected with an x-axis screw 25, and the x-axis screw 25 is in threaded connection with the nut;

the top of the x-direction seat 15 is provided with a y-direction groove, the y-direction seat 14 is arranged in the y-direction groove and slides along the y direction, the x-direction seat 15 is provided with a y-axis motor seat 17 extending towards one side of the x direction, the y-axis motor seat 17 is fixedly connected with a y-axis stepping motor 18, one side of the y-direction seat 15 corresponding to the y-direction seat is provided with an extending y arm 20, a nut is fixedly arranged on the y arm 20, the y-axis stepping motor 18 is fixedly connected with a y-axis screw rod 19, and the y-axis screw rod 19 is in threaded connection with the nut.

In a preferred embodiment, as shown in FIG. 1, a groove is provided on the top of the y-seat 14, facing outward, and the slide rack 13 is disposed in the groove.

In a preferred embodiment, a plurality of screw holes are formed in the x-direction seat and the y-direction seat 14, and the lubricating block is fixedly connected with the screw holes through screws so as to realize the lubrication among the base 26, the x-direction seat 15 and the y-direction seat 14. Not shown in the figures.

In a preferred scheme, the base 26, the z-axis seat 5, the x-direction seat 15 and the y-direction seat 14 are made of aluminum alloy. One is to facilitate machining into complex shapes. Secondly, the dead weight is greatly reduced, and the friction force is reduced. Thirdly, the self-lubricating effect after work hardening is achieved. The utility model discloses a spare part is made with guide structure, drive arrangement's fixed knot to step-by-step objective table, and size precision improves by a wide margin, and the structure is very compact moreover, has reduced micro-scanner's size by a wide margin.

In a preferred scheme, as shown in fig. 2, an x-axis stroke sensor 23 is arranged between an x-axis motor base 22 and an x-axis arm 16 and used for verifying relative displacement between stroboflash between a base 26 and an x-direction base 15;

a y-axis stroke sensor 21 is arranged between the y-axis motor base 17 and the y-arm 20 and used for verifying the relative displacement between stroboflash and the stroboflash between the x-axis base 15 and the y-axis base 14;

the x-axis stroke sensor 23 and the y-axis stroke sensor 21 are laser displacement sensors. If an error is detected, the error value is sent to the memory 4 for storage, preferably the memory 4 uses a combination of ram and ssd. And taking the error value as a correction value in the subsequent image splicing process. With this configuration, the image accuracy is ensured by the post correction while the high efficiency of the open loop control is obtained. I.e. an optimization of efficiency and accuracy is achieved. Preferably, the x-axis stroke sensor 23 and the y-axis stroke sensor 21 use light sources of different wavelengths to avoid interference.

In a preferred scheme, as shown in fig. 1, the z-axis seat 5 is connected with a barrel seat 9, the barrel seat 9 is provided with a vertical through hole, one side of the barrel seat 9 is provided with a slit opening 36, the microscope tube 10 and the industrial camera 33 are arranged in the vertical through hole, and a screw passing through the slit opening 36 is arranged at the position of the slit opening 36.

In a preferred scheme, as shown in fig. 2, a shaft seat 5 is slidably connected with a lens barrel seat 9, a z-axis stepping motor 6 is further arranged on the z-axis seat 5, a screw hole is formed in the lens barrel seat 9, the z-axis stepping motor 6 is fixedly connected with a z-axis screw 7, the z-axis screw 7 is in threaded connection with the screw hole, and the z-axis stepping motor 6 is used for finely adjusting a focus of the lens barrel seat 9. The scheme can focus images among different layers by finely adjusting the focus of the lens barrel seat 9 for pathological tissue images with multilayer structures.

In a preferred scheme, a strobe head 34 is further disposed on the same axis or one side of the microscope tube 10, the strobe head 34 is used for emitting a flash light according to a set frequency according to a continuous walking stroke of the stepping object stage, and the industrial camera 33 collects an image along with the flash frequency of the strobe head 15. The strobe head 34 is configured such that the LED light source 35 is electrically connected to an output terminal of the switching element 27, a control terminal of the switching element 27 is electrically connected to the controller, and an input terminal of the switching element 27 is electrically connected to the power supply 29; the switching element 27 in this example is a PMOS transistor.

Preferably, as shown in fig. 2, an optical compensation sensor 11 is further disposed on one side of the microscope tube 10.

Preferably, as shown in fig. 2, a panoramic lens 12 is further disposed on one side of the microscope tube 10, and the field of view of the panoramic lens 12 covers the entire slide rack 13 or the slide 31. As shown in fig. 5, the panoramic lens 12 is used for acquiring a panoramic image of the encoded image 30 and the tissue sample 32, for obtaining information of the current slide, such as an ID code of the current slide 31, and for guiding a subsequent continuous-walking stroboscopic image acquisition operation, such as may assist the stage in pre-positioning according to the tissue sample 32.

Example 2:

to further understand the present invention, the application scenario of the present invention is further introduced, as shown in fig. 2, a portable full-automatic high-speed micro-scanner using the above-mentioned objective platform, which includes a stepping objective table, a microscope tube 10 and a stroboscopic head 15;

the maximum brightness of the stroboscopic head 15 is 50000lx to 100000 lx, the stepping speed of the stepping object stage is 17 to 20ms/visual field, the numerical aperture of the microscope tube 10 is 0.5 to 0.75, and the exposure time of the industrial camera 33 is 10 to 25 microseconds.

The preferred scheme is as shown in fig. 2, wherein an x-axis stepping motor 24 and a y-axis stepping motor 18 are connected with a controller 3, and the controller 3 adopts open-loop control; with this structure, high work efficiency is obtained. As shown in fig. 3, the apparatus of the present invention, field of view 100 is 16: and 9, the time for completing 1392 views, namely 48 × 29 array scanning is 71 seconds, and after the scanning is completed, the panoramic image is spliced, so that the efficiency is greatly improved compared with the prior art. An artificial intelligence image recognition program is integrated in the industrial personal computer 2, and the range of the tissue sample 32 is recognized through the panoramic image, so that in the subsequent scanning process, the walking path is optimized, unnecessary content-free visual fields are removed in advance, and the scanning speed is further improved.

The controller 3 is connected with the industrial personal computer 2, the industrial personal computer 2 sends a stepping signal to the controller 3, and the industrial personal computer 2 also sends a stroboscopic signal to the stroboscopic head 34 according to the stepping signal and the position corresponding to the visual field 100; the industrial personal computer 2 adopts the same system as the computer to improve the compatibility of control software, splicing software, identification software and other environment software. The industrial personal computer 2 starts the industrial camera 33 to collect images according to the stroboscopic signal and transmits the images to the memory 4. The controller 3 preferably employs a controller of the STM32F series.

In a preferred embodiment, as shown in fig. 2, a display device 1 is further provided, and the display device 1 is integrated on a housing of the micro scanner, so that real-time interaction can be realized. Preferably, the display device 1 is a touch screen. The display device 1 is connected with the industrial personal computer 2, and after the industrial personal computer 2 receives the collected images, the collected images are spliced according to the scanning path 200 and the corresponding coordinates of the field of view 100; i.e., the scanned image, is first cut through the target surface. During the calibration process, the coordinates of each visual field are calibrated, namely, only the first visual field in the first row and the second visual field in the first row are spliced manually or based on an image recognition algorithm to obtain the relative coordinates between the first visual field and the second visual field, the subsequent images are spliced in a coordinate positioning mode according to the relative coordinates, and edge image recognition is not needed in the splicing process. During line changing, the relative coordinates of the inter-line view images are obtained through one-time splicing based on manual work or an image recognition algorithm, subsequent line changing is spliced in a coordinate positioning mode, and edge image recognition is not needed in the splicing process. And introducing an x-direction correction value and a y-direction correction value for correction in the splicing process. Because errors may be generated on the stepping stage due to missing steps, gaps and the like, the accuracy can be ensured by adopting a subsequent correction mode. During calibration, a single pixel under the resolution ratio during splicing corresponds to a real-world size value, and the x-direction correction value and the y-direction correction value can be converted into the number of pixels for compensation and correction, so that the splicing precision of the visual field images is improved. The detection time of the light compensation sensor 11 corresponds to the exposure time of the industrial camera 33. The light intensity values for each field of view are averaged and the difference between the intensity value of the strobe light for each field of view and the average is then determined. And when the difference value exceeds a preset range, performing compensation adjustment on the brightness of the current visual field. By this scheme, the luminance values between the respective fields of view are kept averaged.

The above embodiments are merely preferred technical solutions of the present invention, and should not be considered as limitations of the present invention, and the features in the embodiments and the examples in the present application may be arbitrarily combined with each other without conflict. The protection scope of the present invention shall be defined by the claims and the technical solutions described in the claims, including the technical features of the equivalent alternatives as the protection scope. I.e., equivalent alterations and modifications within the scope of the invention, are also intended to be covered by the scope of this invention.

Claims (10)

1. A kind of objective table used for portable microscopic scanner, its characteristic is: comprises a base (26), a z-axis seat (5), an x-direction seat (15) and a y-direction seat (14);

the X-axis motor base (22) is used for being fixedly connected with an X-axis stepping motor (24), an extending X-axis arm (16) is arranged on one side, corresponding to the X-axis base (15), and a nut is fixedly arranged on the X-axis arm (16), the X-axis stepping motor (24) is fixedly connected with an X-axis screw rod (25), and the X-axis screw rod (25) is in threaded connection with the nut;

be equipped with the recess of y to at the top of x to seat (15), y sets up in the recess of y to seat (14), and slide along y to, be equipped with y axle motor cabinet (17) to x to one side extension to x to seat (15) at x, y axle motor cabinet (17) and y axle step motor (18) fixed connection, be equipped with y arm (20) of extension on y to the corresponding one side of seat (14), the nut has set firmly on y arm (20), y axle step motor (18) and y axle screw rod (19) fixed connection, y axle screw rod (19) and nut threaded connection.

2. The carrier platform of claim 1, wherein: the top of the y-direction seat (14) is provided with a groove body facing to the outside, and the slide rack (13) is arranged in the groove body.

3. A carrier platform for a portable microscopy scanner according to claim 1 wherein: a plurality of screw holes are arranged on the x-direction seat and the y-direction seat (14), and the lubricating block is fixedly connected with the screw holes through screws so as to realize the lubrication among the base (26), the x-direction seat (15) and the y-direction seat (14).

4. The carrier platform of claim 1, wherein: the base (26), the z-axis seat (5), the x-direction seat (15) and the y-direction seat (14) are made of aluminum alloy.

5. The carrier platform of claim 1, wherein: an x-axis stroke sensor (23) is arranged between the x-axis motor base (22) and the x-axis arm (16) and used for verifying the relative displacement between stroboflash between the base (26) and the x-direction base (15);

a y-axis stroke sensor (21) is arranged between the y-axis motor base (17) and the y-axis arm (20) and used for verifying the relative displacement between stroboflash of the x-direction base (15) and the y-direction base (14);

the x-axis stroke sensor (23) and the y-axis stroke sensor (21) adopt laser displacement sensors.

6. The carrier platform of claim 1, wherein: the Z-axis seat (5) is connected with the microscope barrel seat (9), the microscope barrel seat (9) is provided with a vertical through hole, one side of the microscope barrel seat (9) is provided with a slit opening (36), the microscope tube (10) and the industrial camera (33) are arranged in the vertical through hole, and a screw penetrating through the slit opening (36) is arranged at the position of the slit opening (36).

7. The carrier platform for a portable microscopy scanner according to claim 6, wherein: the shaft seat (5) is connected with the lens barrel seat (9) in a sliding mode, the z-axis seat (5) is further provided with a z-axis stepping motor (6), a screw hole is formed in the lens barrel seat (9), the z-axis stepping motor (6) is fixedly connected with a z-axis screw rod (7), the z-axis screw rod (7) is connected with the screw hole in a threaded mode, and the z-axis stepping motor (6) is used for fine adjustment of the focus of the lens barrel seat (9).

8. The carrier platform for a portable microscopy scanner according to claim 6, wherein: the microscope lens cone (10) is coaxial or one side of the microscope lens cone is also provided with a stroboscopic head (34), the stroboscopic head (34) is used for emitting flash light according to a set frequency according to the continuous walking stroke of the stepping object stage, and the industrial camera (33) collects images along with the flash frequency of the stroboscopic head (34).

9. The carrier platform for a portable microscopy scanner according to claim 6, wherein: one side of the microscope tube (10) is also provided with an optical compensation sensor (11).

10. The carrier platform of claim 6, wherein: a panoramic lens (12) is arranged on one side of the microscope tube (10), and the visual field of the panoramic lens (12) covers the whole slide rack (13) or the slide (31).

Images