CN218896047U - Automatic blood smear scanning analysis device - Google Patents

Abstract

The utility model discloses an automatic blood smear scanning and analyzing device which comprises a frame, a storage mechanism arranged on the frame, a scanning carrying platform arranged on the frame, a feeding mechanism with a feeding end connected with the storage mechanism and an output end connected with the scanning carrying platform, and an imaging mechanism arranged on the frame and arranged in the same vertical direction of the scanning carrying platform; the scanning object carrying platform has two horizontal and vertical translational degrees of freedom, and the imaging functional structure of the imaging mechanism has two vertical translational degrees of freedom. The utility model can realize the high-speed movement of the nanometer level within 200 mu m by utilizing the automatic focusing component in the optical mechanism, so that the high-power lens can be used for direct focusing imaging during scanning.

Description

Automatic blood smear scanning analysis device

Technical Field

The utility model relates to the field of blood smear scanning analysis, in particular to an automatic blood smear scanning analysis device.

Background

The blood smear scanning analyzer can automatically load and unload blood smears, complete cell positioning and shooting, cell identification and pre-classification, and display the shot blood cell images to a user, and can replace the manual microscopic examination work to a certain extent. Compared with manual microscopic examination, the working efficiency of the blood smear scanning analyzer is greatly improved.

Current blood smear scanning analyzers consist essentially of a motor-driven XYZ three-axis motion stage and an optical imaging mechanism. The optical imaging mechanism is kept motionless in the shooting process, and the moving platform carries the blood smear for movement and shooting. The shooting mode is as follows: the horizontal motor drives the blood smear and the imaging mechanism to do relative motion in the horizontal direction, and stops for a period of time after reaching the target visual field, and waits for the mechanical device to be completely stationary, so that shake blur is eliminated. And then the motor in the vertical direction drives the blood smear and the imaging mechanism to do relative motion in the vertical direction, so as to focus and photograph. And then the process is repeated continuously, the horizontal motor is started and stopped to reach the adjacent photographing position, and the motor is kept stand for a period of time and focused and photographed. If the area to be scanned is large, the required time is greatly prolonged, and the overall working efficiency is greatly reduced.

There is a need for an automated blood smear scanning analysis apparatus that solves the above-described problems.

Disclosure of Invention

The utility model provides an automatic blood smear scanning and analyzing device, which aims to solve the problems that when the area to be scanned is large, the required time is greatly prolonged and the overall working efficiency is greatly reduced in the traditional blood smear scanning and analyzing device in the prior art.

The utility model provides an automatic blood smear scanning and analyzing device which comprises a frame, a storage mechanism arranged on the frame, a scanning carrying platform arranged on the frame, a feeding mechanism with a feeding end connected with the storage mechanism and an output end connected with the scanning carrying platform, and an imaging mechanism arranged on the frame and arranged in the same vertical direction of the scanning carrying platform;

the scanning object carrying platform has two horizontal and vertical translational degrees of freedom, and the imaging functional structure of the imaging mechanism has two vertical translational degrees of freedom;

the scanning carrying platform comprises a platform body, a light-transmitting window, a slide clamping mechanism, an X-direction moving mechanism and a Y-direction moving mechanism, wherein the platform body is of a square platy structure, the light-transmitting window is arranged in the middle of the platform body, the light-transmitting window is made of light-transmitting materials, the slide clamping mechanism is movably arranged at two sides of the light-transmitting window on the upper surface of the platform body, the moving direction of the slide clamping mechanism is towards the middle of the light-transmitting window, the X-direction moving mechanism and the Y-direction moving mechanism are all arranged at two sides of the platform body and are mutually perpendicular, the free ends of the X-direction moving mechanism and the free ends of the Y-direction moving mechanism are all connected with a frame, and the distance between the X-direction moving mechanism and the connecting end of the platform body and the connecting end of the Y-direction moving mechanism and the connecting end of the frame are adjustable.

The utility model relates to an automatic blood smear scanning analysis device, which is characterized in that an imaging mechanism comprises an imaging camera, an optical path adjusting mechanism, an imaging frame body and a Z-direction adjusting mechanism, wherein the imaging frame body is arranged on the upper surface of a frame, a light-passing hole is formed in the middle of the imaging frame body, the Z-direction adjusting mechanism is arranged on the imaging frame body above the light-passing hole, the imaging camera is vertically arranged on the Z-direction adjusting mechanism, the imaging direction of the imaging camera is vertically downward, the optical path adjusting mechanism is arranged on the frame below a scanning carrying platform, the output direction of the optical path adjusting mechanism passes through a light-passing window and a slide to be detected upwards and is mapped to the imaging end of the imaging camera, and the Z-direction adjusting mechanism has the freedom degree of carrying the imaging camera to vertically move.

The utility model relates to an automatic blood smear scanning and analyzing device, which is characterized in that a storage mechanism comprises a slide box and a pulling piece box clamping mechanism, wherein the slide box is a box-shaped device with front and rear openings for containing vertically stacked slides, the slide box is arranged on the upper surface of the slide box clamping mechanism, and the slide box clamping mechanism is arranged on the upper surface of a frame.

The utility model relates to an automatic blood smear scanning and analyzing device, which is characterized in that a feeding mechanism comprises a pushing rod, a return rod, a guide rail and a power device, wherein the pushing rod and the return rod are movably arranged on the guide rail in parallel, the power device is arranged at one end of the guide rail, an output end of the power device is connected with the pushing rod and the return rod, and the stepping positions of the pushing rod and the return rod penetrate through a slide box.

In the automatic blood smear scanning and analyzing device, the imaging mechanism also comprises an information reading camera fixed on the imaging frame body as an optimal mode.

The automatic blood smear scanning and analyzing device also comprises an oil dripping system which is arranged between the original position of the feeding mechanism and the scanning carrying platform.

The device is characterized in that a slide to be detected is placed in the slide box, then the slide box is inserted into a detection port of equipment, the slide box can descend to a certain height, the slide is pushed onto a scanning object carrying platform by a horizontal push rod, and in the process, a photographing imaging mechanism can detect the number and the position of the slide and complete the reading of information such as a slide two-dimensional code. After the slide reaches the appointed position of the scanning object carrying platform, the slide can be clamped by the clamping mechanism, and the automatic oil dripping mechanism can complete oil covering on the surface of the slide.

In the scanning process, firstly, pre-scanning is carried out, and the unevenness condition and the detailed focusing plane of the blood smear are measured. This is followed by a battlement fold-back motion scan. At the initial position of each row, the optical imaging mechanism directly moves to the focusing plane position measured in the previous step, and focusing positioning is not needed; then the mechanical scanning mechanism drives the slide to move at a uniform speed to reach the end position of the line, meanwhile, the optical imaging mechanism drives the motor to perform precise movement in the vertical direction, the motors in the two directions synchronously move and ensure that the lens is always positioned on a focusing plane, and in the process, a high-speed camera shoots and records images; after that, the motor drives the blood smear to move to the starting position of the next row, and the above process is repeated and the image data is saved.

And after the scanning is finished, the slide is pulled back to the slide box by the slide horizontal pull rod, then the next slide is scanned, the actions are repeated, and after all the slide scans are finished, the slide box returns to the initial position and waits for the next scanning.

The utility model has the following beneficial effects:

the optimization of the mechanical structure in terms of speed and precision is achieved. When the traditional scanning device scans, the movement of the scanning device is stopped every time when one scanning position is changed, and focusing and photographing are performed after the scanning device is stationary for a period of time. The mechanical structure can realize the high-speed movement of the nanometer level within 200 mu m by utilizing an automatic focusing component in the optical mechanism, so that the high-power lens can be used for directly focusing and imaging during scanning. And the focusing assembly can feed back in real time according to the imaging effect, the scanning platform automatically adjusts the position of the imaging mechanism in the motion process, and the lens is always kept on the focusing plane, so that the imaging definition of all areas is ensured. The mechanism and the matched research and development scanning method realize final full-automatic high-speed scanning, and have obvious technical advantages in the aspect of acquisition scanning speed compared with traditional or manual scanning acquisition.

Drawings

FIG. 1 is a schematic diagram of an automated blood smear scanning and analyzing apparatus;

FIG. 2 is a schematic view of a scanning object carrying platform of an automatic blood smear scanning and analyzing device;

FIG. 3 is a schematic diagram of an imaging mechanism of an automated blood smear scanning and analyzing apparatus;

FIG. 4 is a schematic view of a storage mechanism of an automatic blood smear scanning and analyzing device;

fig. 5 is a schematic diagram of a feeding mechanism of an automatic blood smear scanning and analyzing device.

Reference numerals:

1. a frame; 2. a storage mechanism; 21. a slide cassette; 22. a slide cassette clamping mechanism; 3. scanning an object carrying platform; 31. a platform body; 32. a light-transmitting window; 33. a slide clamping mechanism; 34. an X-direction moving mechanism; 35. a Y-direction moving mechanism; 4. a feeding mechanism; 41. a push rod; 42. a return rod; 43. a guide rail; 44. a power device; 5. an imaging mechanism; 51. an imaging camera; 52. an optical path adjusting mechanism; 53. an imaging frame; 54. and a Z-direction adjusting mechanism.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments.

Example 1

As shown in fig. 1, an automatic blood smear scanning and analyzing device comprises a frame 1, a storage mechanism 2 arranged on the frame 1, a scanning carrying platform 3 arranged on the frame 1, a feeding mechanism 4 with a feeding end connected with the output end of the storage mechanism 2 and connected with the scanning carrying platform 3, an imaging mechanism 5 arranged on the frame 1 and arranged in the same vertical direction of the scanning carrying platform 3, and an oil dripping system;

the scanning loading platform 3 has two horizontal and vertical translational degrees of freedom, the imaging functional structure of the imaging mechanism 5 has two vertical translational degrees of freedom, and the oil dripping system is arranged between the original position of the feeding mechanism 4 and the scanning loading platform 3.

The oil dripping system comprises an oil storage pot, an oil suction pump, a control electromagnetic valve, an oil pipe and a fixing mechanism thereof, and can automatically drip the mirror oil on the glass slide. And leakage and self-loss are effectively prevented.

The function of automatically scanning the blood morphology slide is effectively realized through the mechanical structure. It is difficult in the prior art to divide the individual structural and functional parts so clearly that our mechanism can be broken into individual component parts, each of which can perform its own mechanical function.

The design of the main frame is extremely simplified, the disassembly and the maintenance are convenient, all design data are obtained through finite element analysis and calculation, the maximum unification of static stress, dynamic stress and yield strength is theoretically realized, the optimization design is realized through the influence of displacement deformation and deflection, the reliability and the stability of the whole mechanical device are ensured, meanwhile, the whole strength analysis is also completed through computer simulation, and the existence of a strength short plate is eliminated.

As shown in fig. 2, the scanning carrying platform 3 includes a platform body 31, a transparent window 32, a slide clamping mechanism 33, an X-direction moving mechanism 34 and a Y-direction moving mechanism 35, the platform body 31 is in a square plate structure, the transparent window 32 is arranged in the middle of the platform body 31, the transparent window 32 is made of light-transmitting material, the slide clamping mechanism 33 is movably arranged at two sides of the transparent window 32 on the upper surface of the platform body 31, the slide clamping mechanism 33 is movably arranged at the middle of the transparent window 32, the X-direction moving mechanism 34 and the Y-direction moving mechanism 35 are respectively arranged at two sides of the platform body 31 and are mutually perpendicular, the free ends of the X-direction moving mechanism 34 and the Y-direction moving mechanism 35 are respectively connected with the frame 1, and the distance between the connection end of the X-direction moving mechanism 34 and the platform body 31 and the connection end of the X-direction moving mechanism 34 and the frame 1, and the connection end of the Y-direction moving mechanism 35 and the frame 1 are adjustable. After the slide pushing mechanism sends the slide to the scanning platform, the clamping mechanism clamps the slide, the mechanical scanning is responsible for the horizontal movement of the X axis and the Y axis, and the slide pushing mechanism sends the slide after the scanning is finished.

The scanning carrying platform 3 is a high-precision displacement platform, can realize working scanning and positioning at intervals of 100 microns, and the clamping mechanism can automatically clamp a slide to be scanned. When the scanning platform moves horizontally, the light path is kept still, the light source transmits the scanning slide through the light hole of the platform and then amplifies 1000 times through the microscope lens, and the camera is used for collecting and imaging.

As shown in fig. 3, the imaging mechanism 5 includes an imaging camera 51, an optical path adjusting mechanism 52, an imaging frame 53, a Z-direction adjusting mechanism 54 and an information reading camera, the imaging frame 53 is disposed on the upper surface of the frame 1, a light-passing hole is disposed in the middle of the imaging frame 53, the Z-direction adjusting mechanism 54 is disposed on the imaging frame 53 above the light-passing hole, the imaging camera 51 is vertically mounted on the Z-direction adjusting mechanism 54, the imaging direction of the imaging camera 51 is vertically downward, the optical path adjusting mechanism 52 is disposed on the frame 1 below the scanning carrier platform 3, the output direction of the optical path adjusting mechanism 52 passes through the light-passing window 32 and a slide to be detected upwards and is mapped to the imaging end of the imaging camera 51, and the Z-direction adjusting mechanism 54 has a degree of freedom for carrying the vertical movement of the imaging camera 51. The information reading camera is fixed to the imaging frame 53. And the light path imaging and light path adjustment of the scanning process are carried out.

The light path adjustment mechanism 52 can manually perform five-degree-of-freedom adjustment of the light source XYZ and XY small-angle rotation. The basic function is also applicable to other occasions.

The imaging mechanism 5 can realize blood cell morphology data scanning through a high-speed camera, and can feed back in real time according to imaging definition, adjust nanoscale high-precision distance control within 200 micrometers in the vertical direction (Z direction), and ensure definition of a scanned image. The response speed of the real-time feedback mechanism is less than 10ms, so that the camera can continuously collect in real time, repeated focusing is not required to be stopped, and the collection high-speed performance of the device is ensured.

The information reading camera can take a picture of the glass slide and recognize the head two-dimensional code information of the glass slide; the imaging camera 51 in this embodiment is a sample detection camera that recognizes the number and position of slides in the slide cassette and feeds the data back to the industrial personal computer for subsequent movement and scanning.

As shown in fig. 4, the storage mechanism 2 comprises a slide cassette 21 and a slide cassette clamping mechanism 22, the slide cassette 21 is a box-shaped device with front and rear openings for containing vertically stacked slides, the slide cassette 21 is mounted on the upper surface of the slide cassette clamping mechanism 22, and the slide cassette clamping mechanism 22 is mounted on the upper surface of the frame 1. The slide box 21 and the slide box clamping mechanism 22 are responsible for loading slides and clamping the slide box, and are provided with micro switches, after the slide box 21 is pushed in along the clamping groove, the micro switches are just triggered after the slide box 21 is pushed in place, so that the placement position of the slide box 21 is ensured to be fixed every time. And a lifting motor and a fixing mechanism thereof can realize the lifting of the slide box 21.

In this embodiment, the slide cassette 21 is lowered to a certain height, the slide is pushed onto the mechanical scanning platform by the slide horizontal pushing rod, and the subsequent scanning operation is performed, and after the scanning operation is completed, the slide is pulled back into the slide cassette by the slide horizontal pulling rod, and returns to the initial position.

The slide cassette 21 can be self-clamped, and the slide cassette clamping mechanism assembly 22 can automatically prevent foolproof positioning and clamping, thus completing initial positioning of the slide cassette 21.

As shown in fig. 5, the feeding mechanism 4 includes a pushing rod 41, a return rod 42, a guide rail 43 and a power device 44, where the pushing rod 41 and the return rod 42 are movably disposed on the guide rail 43 in parallel with each other, the power device 44 is disposed at one end of the guide rail 43, the output end of the power device is connected with the pushing rod 41 and the return rod 42, and the stepping positions of the pushing rod 41 and the return rod 42 pass through the slide box 21.

The whole mechanism can accurately realize that the slide is automatically pushed to the scanned position by the stepping motor and is fixed by the slide clamping device. The scanning platform precisely controls the slide to rapidly move to a scanning position and shoot imaging according to a scanning algorithm. After all the slides are scanned, the pushing rod is connected with the pull rod follower through the pull rod connector, and the slides are automatically returned to the original positions of the slide boxes. Then the slide box is switched to another slide position to be scanned, the instrument can repeatedly and automatically scan any slide in the slide box and automatically return to the original position, and the structure is an indispensable step in full automation and can be used for other occasions to complete the same function.

In this embodiment, specific parameters are as follows:

rated input power: 320W;

maximum size of the device: 700mm long, 350mm wide, 534.5mm high, tolerance + -5%;

scanning range: 15mm in the transverse direction and 25mm in the longitudinal direction, and the tolerance is +/-10%;

sheet feeding part transport distance: 500mm, tolerance + -10%;

each standard slide scan time: 10min, tolerance ± 10%;

scanning slide size: thickness 1mm, width 25mm, length 76mm, tolerance + -1%;

slide volume: 12 tablets;

fastest movement speed: 15mm/s.

The foregoing is only a preferred embodiment of the present utility model, but the scope of the present utility model is not limited thereto, and any person skilled in the art, who is within the scope of the present utility model, should make equivalent substitutions or modifications according to the technical scheme of the present utility model and the inventive concept thereof, and should be covered by the scope of the present utility model.

Claims (6)

1. An automatic blood smear scanning and analyzing device, which is characterized in that: the device comprises a frame (1), a storage mechanism (2) arranged on the frame (1), a scanning carrying platform (3) arranged on the frame (1), a feeding mechanism (4) with a feeding end connected with the output end of the storage mechanism (2) and connected with the scanning carrying platform (3), and an imaging mechanism (5) which is arranged on the frame (1) and arranged in the same vertical direction of the scanning carrying platform (3);

the scanning object carrying platform (3) has two horizontal and vertical translational degrees of freedom, and the imaging functional structure of the imaging mechanism (5) has two vertical translational degrees of freedom;

the scanning carrying platform (3) comprises a platform body (31), a light transmission window (32), a slide clamping mechanism (33), an X-direction moving mechanism (34) and a Y-direction moving mechanism (35), wherein the platform body (31) is of a square platy structure, the light transmission window (32) is arranged in the middle of the platform body (31), the light transmission window (32) is made of light-transmitting materials, the slide clamping mechanism (33) is movably arranged at two sides of the light transmission window (32) on the upper surface of the platform body (31), the slide clamping mechanism (33) is movably arranged at the middle of the light transmission window (32) in the direction, the X-direction moving mechanism (34) and the Y-direction moving mechanism (35) are arranged at two sides of the platform body (31) and are perpendicular to each other, the free end of the X-direction moving mechanism (34) and the free end of the Y-direction moving mechanism (35) are connected with the frame (1), and the connecting end of the platform body (31) and the Y-direction moving mechanism (34) are connected with the frame (35) in the direction adjustable distance between the connecting end of the frame (31) and the frame (35).

2. An automated blood smear scan analysis apparatus as claimed in claim 1 wherein: imaging mechanism (5) are including imaging camera (51), light path adjustment mechanism (52), imaging support body (53) and Z direction adjustment mechanism (54), imaging support body (53) set up in frame (1) upper surface, imaging support body (53) middle part sets up logical unthreaded hole, Z direction adjustment mechanism (54) set up in logical unthreaded hole top imaging support body (53) are last, imaging camera (51) are vertical to be installed on Z direction adjustment mechanism (54), imaging camera (51) imaging direction is vertical downwards, light path adjustment mechanism (52) set up in scanning carrier platform (3) below frame (1), light path adjustment mechanism (52) output direction upwards pass printing opacity window (32) and the slide that waits to detect map to imaging end of imaging camera (51), Z direction adjustment mechanism (54) have and carry imaging camera (51) vertical movement's degree of freedom.

3. An automated blood smear scan analysis apparatus as claimed in claim 1 wherein: the storage mechanism (2) comprises a slide box (21) and a slide box clamping mechanism (22), the slide box (21) is a box-shaped device with front and rear openings for containing vertically stacked slides, the slide box (21) is mounted on the upper surface of the slide box clamping mechanism (22), and the slide box clamping mechanism (22) is mounted on the upper surface of the frame (1).

4. An automated blood smear scan analysis apparatus as claimed in claim 3 wherein: feed mechanism (4) are including push rod (41), return pole (42), guide rail (43) and power device (44), push rod (41) with return pole (42) are parallel to each other movable the setting is in on guide rail (43), power device (44) set up in guide rail (43) one end and output are connected push rod (41) with return pole (42), push rod (41) with return pole (42) step position is passed slide casket (21).

5. An automated blood smear scan analysis apparatus as claimed in claim 2 wherein: the imaging mechanism (5) further comprises an information reading camera fixed on the imaging frame (53).

6. An automated blood smear scan analysis apparatus as claimed in claim 1 wherein: the automatic blood smear scanning analysis device further comprises an oil dripping system, wherein the oil dripping system is arranged between the original position of the feeding mechanism (4) and the scanning carrying platform (3).

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