CN213633134U - Pathological section scanner - Google Patents

Abstract

The utility model discloses a pathological section scanner, which comprises a moving device, a positioning device, a scanning device, a light source and an objective table for placing pathological sections; the moving device can drive the object stage to move in the horizontal direction, and when the object stage moves to the position below the positioning device, the positioning device can acquire images of pathological sections so as to identify an initial position; when the objective table moves to the lower part of the scanning device, the scanning device can carry out image acquisition and scanning on the pathological section. The utility model discloses can remove to positioner and scanning device through mobile device with the slide glass that has pathological section, thereby positioner can carry out image acquisition to pathological section and discern initial position, and scanning device can carry out image acquisition scanning to pathological section to the form of machine simulates the observation of people's eye and the microscopical perspective and reads pathological section.

Description

Pathological section scanner

Technical Field

The utility model relates to a pathological section scanner.

Background

Pathological examination is a pathomorphological method for examining pathological changes in organs, tissues or cells of the body. In order to study the disease process of organs, tissues or cells, some kind of pathological morphological examination method can be used to examine the pathological changes of them, study the cause, pathogenesis and the process of pathological changes, and finally make pathological diagnosis. The pathological morphological examination method is that the pathological change of the general specimen is observed, then the pathological tissue with certain size is cut out, the pathological section is made by the pathological histological method, and the pathological change is further examined by a microscope.

The digital section system can rapidly scan the whole glass slide in a full-information and all-round way, so that the traditional materialized glass slide becomes a new generation of digital pathological section, and the digital section system is an epoch-making revolution for realizing pathological diagnosis technology. The system can separate a pathologist from a microscope, solve pathological diagnosis through a network at any time and any place, realize global online synchronous remote consultation or offline remote consultation, and has great significance for time and space alternation and transmission advantages of diagnosis value equal to that of microscope observation due to the fact that full-section information is provided. And multilayer three-dimensional reconstruction of pathological sections and management digitization of the pathological sections are also realized. The system can be widely used for pathological clinical diagnosis, pathological teaching, histological cell imaging, fluorescence analysis and immunohistochemical digital imaging. The glass slice is scanned into a digital slice, so that the storage and the circulation are convenient; just like scanning the common developed photo into a digital photo, the photo can be read and examined on a computer without singly observing the photo by using a microscope.

The existing digital pathological section scanner is internally provided with a section scanning part and a section replacing part, but the existing digital pathological section scanner basically adopts a mode of controlling the scanner to work by a computer, so that the following defects are caused: 1. when the worker finishes loading the slices at the scanner end, the worker needs to go to the computer to operate and know the working state of the scanner, and if the worker operates for multiple times, the worker needs to go back and forth between the scanner and the computer for multiple times, so that the time of the worker is wasted, and the working efficiency is also reduced. 2. The working state of the scanner cannot be known in real time, and if the working state of the scanner needs to be known, the scanner needs to be checked in front of a computer. 3. Because the loading and the scanning are carried out on the two machines, the workers cannot directly operate at the scanner after loading. Meanwhile, the section is made of glass and has the characteristics of fragility, smoothness and thinness, so that the section is difficult to take and place safely, and the flatness of the section is easy to influence when the section is arranged in a section replacement part.

For example, the scanning device of Japanese Komatsushi Kogyo, Kohamamatsu, for example, with patent number TW108124608, it is known to use a full scan of the stage for the acquisition. For example, corresponding equipment designed by domestic Jiangsu Disceter medical science and technology Limited also only adopts full-automatic design as far as possible, but does not have a better mode for improving the scanning efficiency.

SUMMERY OF THE UTILITY MODEL

The utility model discloses an overcome prior art not enough, provide a pathological section scanner.

In order to achieve the above purpose, the utility model adopts the following technical scheme: a pathological section scanner comprises a moving device, a positioning device, a scanning device, a light source and an object stage for placing pathological sections; the moving device can drive the object stage to move in the horizontal direction, and when the object stage moves to the position below the positioning device, the positioning device can acquire images of pathological sections so as to identify an initial position; when the objective table moves to the lower part of the scanning device, the scanning device can carry out image acquisition and scanning on the pathological section.

Further, the method comprises the following steps of; the light source comprises a positioning light source and a scanning light source, and the area of the positioning light source is larger than that of the scanning light source.

Further, the method comprises the following steps of; the device also comprises a base; the moving device comprises an X-axis moving device and a Y-axis moving device, the moving tracks of the Y-axis moving device and the moving tracks of the X-axis moving device are mutually vertical, the X-axis moving device is installed on the base, and the Y-axis moving device is connected with the X-axis moving device through a connecting plate.

Further, the method comprises the following steps of; the objective table includes the installation department, and the installation department is provided with the installation position that can place the slide glass and can restricts the spacing piece of slide glass activity, and installation position bottom surface is for supplying the logical groove that the light source pierces through.

Further, the method comprises the following steps of; the glass slide rack is characterized by further comprising a rack, wherein an opening capable of placing or taking out a glass slide is formed in the rack, and the opening and the installation position are located on the same horizontal plane.

Further, the method comprises the following steps of; the scanning device comprises a scanning acquisition device and a Z-axis lifting device; the Z-axis lifting device can control the scanning and collecting device to ascend or descend in the vertical direction.

Further, the method comprises the following steps of; the X-axis moving device comprises an X-axis guide rail, an X-axis sensor, an X-axis power part, an X-axis moving part and an X-axis switch fixed on the X-axis moving part; the X-axis power part can control the X-axis moving part to move along the X-axis guide rail, and the X-axis sensor and the X-axis switch can control the X-axis moving part to start or stop.

Further, the method comprises the following steps of; the Y-axis moving device comprises a Y-axis guide rail, a Y-axis sensor, a Y-axis power part, a Y-axis moving part, a Y-axis mounting plate and a Y-axis switch fixed on the Y-axis moving part; the Y-axis power part can control the Y-axis moving part to move along the Y-axis guide rail, the Y-axis sensor and the Y-axis switch can control the Y-axis moving part to start or stop, and the Y-axis sensor is fixed on the connecting plate through the Y-axis mounting plate.

Further, the method comprises the following steps of; the Z-axis lifting device comprises a Z-axis driving part and a Z-axis mounting part, the Z-axis mounting part is used for mounting the scanning and collecting device, and the Z-axis driving part can move the Z-axis mounting part in the vertical direction.

Further, the method comprises the following steps of; positioning a light source to be an LED light plate; the scanning light source is an LED lamp.

To sum up, the utility model discloses can remove to positioner and scanning device through mobile device with the slide glass that has pathological section, thereby positioner can carry out image acquisition to pathological section and discern initial position, and scanning device can carry out image acquisition scanning to pathological section to the form of machine simulates the observation of people's eye and microscopical perspective and reads pathological section.

Drawings

Fig. 1 is a schematic front structural view of the present invention.

Fig. 2 is a schematic structural diagram of the X-axis moving device of the present invention.

Fig. 3 is the schematic view of the split structure of the X-axis moving device of the present invention.

Fig. 4 is a schematic structural view of the Y-axis moving device of the present invention.

Fig. 5 is a schematic view of the split structure of the Y-axis moving device of the present invention.

Fig. 6 is a schematic structural view of the objective table of the present invention.

Fig. 7 is a schematic structural diagram of the positioning device of the present invention.

Fig. 8 is a schematic structural diagram of the scanning device of the present invention.

Fig. 9 is a schematic structural view of the Z-axis lifting device of the present invention.

Detailed Description

In order to make the technical field personnel understand the utility model discloses the scheme, will combine the drawing in the embodiment of the utility model below, to the technical scheme in the embodiment of the utility model carries out clear, complete description.

The utility model relates to an equipment that can carry out the detection scanning to the histopathology section, main step will be earlier put into the objective table of this equipment with the slide glass that has the histopathology section, and the histopathology section of placing on the slide glass contains the pathological tissue who gathers from the patient on one's body usually, need carry out certain order's observation to the case tissue in the section through modes such as microscope through the people's eye among the prior art to whether the discovery has pathological change abnormal form, through the utility model discloses an equipment can convert manual observation into machine scanning to the observation of the form simulation people's eye of machine and microscopic perspective, specific course of work is: the objective table is moved to the positioning device firstly, the positioning device carries out preliminary scanning and positioning on pathological sections on the glass slide, the initial position of an image of the pathological sections is determined by identifying the initial position marks preset on the glass slide (the initial position marks can be marked on the glass slide by adopting crossed or similar marks and can be identified), then the objective table is moved to the scanning device, the scanning device can further scan the pathological sections, meanwhile, the objective table can be moved under the driving of the driving part and can be moved and scanned in different areas, so that the aim of carrying out regional scanning on the glass slide by the scanning device is fulfilled, the whole image of the glass slide with infinite size (or more than the lens range) can be completely read by utilizing the scanning lens with finite size through regional scanning, and the whole section state can be completely observed, after all pathological sections are scanned, the objective table can move the glass slide with the pathological sections out of the equipment, so that the glass slide can be conveniently taken back.

As shown in fig. 1-6, a precise feeding device for pathological section; comprises a moving device for placing a pathological section object stage 1, a light source 2 and controlling the object stage 1 to move; the moving means can move the stage 1 above the light source 2. The moving device comprises an X-axis moving device 3 and a Y-axis moving device 4, the moving tracks of the Y-axis moving device 4 and the X-axis moving device 3 are mutually vertical, the X-axis moving device 3 and the light source 2 are both arranged on the base 10, and the Y-axis moving device 4 is connected with the X-axis moving device 3 through a connecting plate 49.

In short, the Y-axis moving device 4 and the X-axis moving device 3 mainly realize the movement of the stage 1 in the horizontal direction, and the movement is mainly to move the slide 9 with the pathological section to each station at present. Of course, the moving tracks of the Y-axis moving device 4 and the X-axis moving device 3 are both straight lines and perpendicular to each other. The Y-axis moving device 4, the X-axis moving device 3, and the stage 1 are disposed one by one, the X-axis moving device 3 is disposed at the bottommost portion, the Y-axis moving device 4 is disposed on the upper portion of the X-axis moving device 3, and the stage 1 is disposed on the upper portion of the Y-axis moving device 4, that is, when the X-axis moving device 3 moves, the Y-axis moving device 4 and the stage 1 can be linked with each other, and when the Y-axis moving device 4 moves, only the stage 1 is linked with each other.

The X-axis moving device 3 comprises an X-axis guide rail 31, an X-axis sensor 32, an X-axis power part 33, an X-axis moving part 34 and an X-axis switch 35 fixed on the X-axis moving part 34; the X-axis power unit 33 can control the X-axis moving unit 34 to move along the X-axis guide rail 31, and the X-axis sensor 32 and the X-axis switch 35 can control the X-axis moving unit 34 to start or stop. The X-axis sensor 32 includes a first X-axis sensor 321, a second X-axis sensor 322, and a third X-axis sensor 323; the three sensors are positioned on the same straight line and can be matched with an X-axis switch 35 for position detection, taking a photoelectric sensor as an example, the X-axis sensor 32 is a photoelectric sensor, and the X-axis switch 35 is a photoelectric sensor switch; the X-axis power section 33 includes a first motor 331 and a first lead screw 332; the X-axis moving part 34 includes a first slider 341 and a first moving member 342, the first slider 341 is slidable along the X-axis guide rail 31, one end of the first moving member 342 is connected to the first lead screw 332, the other end is connected to the first slider 341, and the connecting plate 49 and the X-axis switch 35 are both mounted on the first moving member 342.

The Y-axis moving device 4 includes a Y-axis guide rail 41, a Y-axis sensor 42, a Y-axis power unit 43, a Y-axis moving unit 44, a Y-axis mounting plate 46, and a Y-axis switch 45 fixed to the Y-axis moving unit 44; the Y-axis power part 43 can control the Y-axis moving part 44 to move along the Y-axis guide rail 41, the Y-axis sensor 42 and the Y-axis switch 45 can control the Y-axis moving part 44 to start or stop, and the Y-axis sensor 42 is fixed on the connecting plate 49 through the Y-axis mounting plate 46; the Y-axis sensor 42 includes a first Y-axis sensor 421, a second Y-axis sensor 422, and a third Y-axis sensor 423; the three sensors are positioned on the same straight line and can be matched with the Y-axis switch 45 for position detection; taking a photoelectric sensor as an example, the Y-axis sensor 42 is a photoelectric sensor, and the Y-axis switch 45 is a photoelectric sensor switch; the Y-axis power section 43 includes a second motor 431 and a second lead screw 432; the Y-axis moving part 34 includes a second slider 441 and a second moving member 442, the second slider 441 is slidable along the Y-axis guide rail 41, one end of the second moving member 442 is connected to the second lead screw 432, the other end is connected to the second slider 441, and the Y-axis switch 45 is mounted on the first moving member 342; the Y-axis rail 41 is mounted on the connecting plate 49.

Specifically, when the slide glass 9 is mounted on the stage 1 or removed from the stage 1, it is determined as the initial position of the stage 1, at this time, the X-axis switch 35 is located at the foremost end of the X-axis sensor 32, the Y-axis switch 45 is also located at the foremost end of the Y-axis sensor 42, and then the X-axis power portion 33 is activated, so as to drive the stage 1 to move to the first station, i.e., below the positioning and collecting device 6, along the X-axis guide rail 31, and when the X-axis switch 35 is operated to the position of the first X-axis sensor 321, the stage 1 is determined as being already located below the positioning and collecting device 6 in the X-axis direction, and the X-axis power portion 33 can be turned off; the Y-axis power portion 43 is activated to drive the object stage 1 to move to the first station, i.e. below the positioning and collecting device 6, along the Y-axis guide rail 41, when the Y-axis switch 45 is operated to the position of the first Y-axis sensor 421, the object stage 1 is determined to be already below the positioning and collecting device 6 in the Y-axis direction, and the Y-axis power portion 43 can be closed; in brief, when the Y-axis switch 45 is operated to the position of the first Y-axis sensor 421, and the X-axis switch 35 is operated to the position of the first X-axis sensor 321, the stage 1 is determined to be under the positioning and collecting device 6, and the stage 1 can stop moving, at this time, the positioning and collecting device 6 can perform preliminary image scanning on the slide glass 9 under the positioning and collecting device to determine the initial position of the pathological section image.

It should be noted that the X-axis moving device 3 and the Y-axis moving device 4 may move simultaneously or may move separately and sequentially, and when the Y-axis switch 45 and the X-axis switch 35 are operated to the first Y-axis sensor 421 and the first X-axis sensor 321, respectively, the stage 1 may stop moving in the X-axis direction and the Y-axis direction simultaneously. After the scanning is completed, the Y-axis power portion 43 and the X-axis power portion 33 can be activated to move the object stage 1 continuously, when the X-axis switch 35 runs to the second X-axis sensor 322 and the Y-axis switch 45 runs to the second Y-axis sensor 422, the object stage 1 can be moved to the second station, i.e. below the scanning and collecting device 7, at this time, the scanning and collecting device 7 can scan the slide glass 9 with pathological section below, and the moving mode and principle are the same as those of moving to the positioning and collecting device 6, so the description is not repeated. While the third Y-axis sensor 423 and the third X-axis sensor 323 can be considered as the extreme positions of the stage 1, when the Y-axis switch 45 and the X-axis switch 35 are operated to the third Y-axis sensor 423 and the third X-axis sensor 323, the stage 1 cannot move any further.

The utility model discloses a slide glass that location collection device 6 and scanning collection device 7 gathered and pathological section's image can be through data line transmission to the PC on, carries out image concatenation and contrast on the PC, and the image after the concatenation can let the doctor carry out audio-visual observation very simply to carry out pathological analysis, wherein, location collection device 6 can only play the effect of shooting collection image, need not enlarge and refine the discernment, and scanning collection device 7 can adopt the combination of high power microscope + high definition digtal camera, comes the meticulous detail image of shooting pathological section, also can adopt ordinary high definition digtal camera to scanning collection device 7 and install microscopical mode and realize, the utility model discloses a slide glass that location collection device 6 and scanning collection device 7 gathered and pathological section's image can pass through data line transmission to the PC. To data transmission and figure concatenation and contrast etc, can adopt prior art in the scheme of this embodiment, the utility model discloses the improved machinery and the drive structure of mainly in the equipment.

As shown in fig. 7, when the object stage 1 is moved to the first station, the positioning device starts to work, and a positioning device for pathological section comprises the object stage 1, a positioning light source 21 and a positioning acquisition device 6; the positioning and collecting device 6 is located above the positioning light source 21, the objective table 1 is located between the positioning light source 21 and the positioning and collecting device 6, the objective table 1 is provided with an installation part 11 for placing pathological sections, the installation part 11 can drive the pathological sections to move synchronously, and the positioning and collecting device 6 can carry out image acquisition on the pathological sections to identify the initial position. The pathological section is placed on the slide glass 9, the area of the positioning light source 21 is larger than that of the slide glass 9, and preferably, the positioning light source 21 is an LED light plate. The positioning and collecting device 6 can identify and position an initial position of the slide glass 9 with pathological sections, and when the images are collected in a positioning mode, the images of the whole pathological sections need to be collected, so that the area of the positioning light source 21 is set to be larger than that of the slide glass 9, the slide glass 9 can be integrally illuminated, and the pattern of the whole pathological section can be collected conveniently. In order to ensure the brightness of the positioning light source 21, the positioning light source 21 is arranged on a mounting table 23, and the mounting table 23 is fixed on the base 10, so that the positioning light source 21 can be closer to the object stage 1, and the illumination intensity of the slide glass 9 is improved.

The object stage 1 comprises a mounting part 11, the mounting part 11 is provided with a mounting position 14 for placing the glass slide 9 and a limiting sheet 13 for limiting the movement of the glass slide 9, preferably, the limiting sheets 13 are arranged on two sides of the mounting position 14 in pairs, the bottom surface of the mounting position 14 is a through groove 12 for the positioning light source 21 to penetrate through, the utility model also comprises a base 10 and a frame 15, an opening 16 for placing or taking out the slide glass 9 is arranged on the frame 15, the opening 16 is on the same horizontal plane with the mounting position 14, specifically, the opening 16 is arranged in parallel with the mounting part 11, so as to facilitate the slide glass to be placed in or taken out from the object stage, the height of the mounting position 14 is matched with that of the glass slide 9, and the limiting piece 13 is arranged to ensure that the glass slide 9 does not displace in the moving process, so that the glass slide 9 is firmly fixed on the mounting position 14, and the accuracy of the detection result is ensured. The through grooves 12 can ensure that the pathological section on the glass slide 9 can obtain enough light source, and the area of the through grooves 12 is certainly larger than that of the pathological section, so that the pathological section can obtain enough light source. The scanning is completed at this station of the device to be positioned, an initial position of the pathological section is obtained from the scanned image, and the stage 1 with the slide 9 is then moved to the second station, i.e. below the scanning device.

As shown in fig. 8-9, when the object stage 1 is moved to the second station, the scanning device starts to work, and a pathological section scanning device comprises an object stage 1, a scanning light source 22, a scanning acquisition device 7 and a Z-axis lifting device 5; the scanning and collecting device 7 is positioned above the scanning light source 22, the object stage 1 is provided with a mounting part 11 for placing pathological sections, the Z-axis lifting device 5 can control the scanning and collecting device 7 to ascend or descend in the vertical direction, namely, the distance from a camera of the scanning and collecting device 7 to a case section can be controlled, and when the mounting part 11 is positioned right below the scanning and collecting device 7, the scanning and collecting device 7 can carry out image collecting and scanning on the pathological sections; preferably, the area of the scanning light source 22 is smaller than that of the slide glass 9, and the scanning light source 22 is an LED lamp; the scanning device needs to scan the patient's section precisely, so the scanning light source 22 is set to irradiate the patient's section in a point-like manner, thereby achieving precise and precise scanning. The scanning and collecting device 7 comprises a microscope and can carry out magnification scanning on the section of the case.

The Z-axis lifting device 5 comprises a Z-axis driving part 51 and a Z-axis mounting part 52, the Z-axis mounting part 52 is used for mounting the scanning acquisition device 7, and the Z-axis driving part 51 can enable the Z-axis mounting part 52 to move in the vertical direction; the Z-axis driving part 51 includes a third motor 511, a Z-axis guide rail 512, and a Z-axis slider 513; the Z-axis slider 513 is fixed to the Z-axis mounting portion 52 and is movable along the Z-axis guide rail 512; the Z-axis mounting portion 52 is L-shaped, and includes a Z-axis moving member 521 and a Z-axis supporting member 522, the Z-axis moving member 521 is fixed to the Z-axis sliding block 513, and the Z-axis supporting member 522 is used for fixing the scanning and collecting device 7; a U-shaped opening 523 is arranged on the Z-axis supporting piece 522, and the scanning acquisition device 7 is arranged at the U-shaped opening 523; therefore, the scanning and collecting device 7 can be installed more firmly, and the scanning and collecting device 7 is ensured not to move in the scanning process. The Z-axis lifting device 5 can control the distance from the scanning and collecting device 7 to the glass slide 9 with pathological sections, and can further ensure that the scanning and collecting device 7 can accurately and omnidirectionally scan the pathological sections.

In addition, when the object stage 1 moves to the second station, that is, directly under the scanning and collecting device 7, in order to ensure the omnidirectionality and accuracy of the scanning, the scanning and collecting device 7 can perform regional scanning on pathological sections. And also the scanning acquisition device 7, during the scanning process, the X-axis moving device 3 can drive the pathological section to move along a straight line, and the movement is very small, and the first screw rod 332 can perform a small adjusting movement.

A partition scanning device for pathological sections further comprises a moving device on the basis of the scanning device; specifically speaking, scanning collection system 7 is located scanning light source 22's top, and objective table 1 sets up between scanning light source 22 and scanning collection system 7, is provided with the installation department 11 that is used for placing pathological section on objective table 1, and installation department 11 can drive pathological section horizontal linear motion under mobile device's control, and Z axle elevating gear 5 can control scanning collection system 7 and rise or descend in vertical direction, and scanning collection system 7 can carry out image partition scanning to pathological section. That is, the scanning light source 22 is located under the scanning and collecting device 7, when the scanning light source 22 irradiates on a pathological section region, the scanning and collecting device 7 can collect and scan pathological sections on the region, and when the moving device drives the slide glass 9 with pathological sections to move for a certain distance, the scanning light source 22 irradiates on another pathological section region, which is very small in movement, and the scanning light source 22 also irradiates in a point shape, therefore, the scanning and collecting device 7 can realize accurate image collection of pathological sections in a certain region, that is, the scanning and collecting device 7 only collects pathological sections in a point irradiation range region of the scanning light source 22.

It should be noted that the distance moved in each scanning operation is such that the same portion of the photographed picture at the moment is 1/4 or more as that of the previous picture, and the same portion of the same-position portion is 1/4 or more as that of the previous picture every time the scanning area is changed. Wherein the adjustment distance of each up-and-down movement is related to the distance of each rotation of the motor of the moving device. After all the scans are finished, the final imaging can be carried out in an image splicing mode; the image information that will shoot is transmitted the host computer by central processing unit, carries out image data's analysis processes by the host computer, splices into complete scanogram with the image, and image analysis is carried out to rethread neural network, and the manual work carries out the sign of testee pathological tissue earlier, forms the model training set, scans new pathological tissue again and carries out the sign, and the sign result must reach hundreds of pathological structures part sign, and the sign probably contains the tissue of no pathological structure part, and follow-up is judged by the doctor.

To sum up, the utility model comprises a moving device, a positioning device, a scanning device, a light source 2 and an objective table 1 for placing pathological sections; a central processing unit, an upper computer and the like are also configured for reading the result of scanning the pathological section; the upper computer is electrically connected with the central processing unit or transmits data through a wireless transmission protocol. The positioning device is used for confirming the position of the slide glass 9 with the histopathology on the object stage 1, confirming the position of the slide glass with the corresponding histopathology and providing control information of corresponding coordinate conversion; namely, determining the initial position of the image, connecting the scanning device with the central processing unit, and scanning and collecting the histopathology information; the central processing unit processes the information collected by the scanning device and the positioning device and transmits the information to the upper computer for image analysis and processing; and the upper computer performs image generation and data analysis processing on the information sent by the central processing unit.

The mobile device forms the adjustment of each station in the whole instrument, ensures that the object stage 1 with pathological sections is accurately conveyed to the scanning device and the positioning device, and realizes the initial positioning of the initial coordinate; meanwhile, the purpose of regional scanning of pathological sections by the scanning device is also achieved, and the pathological sections can be presented in an image form more comprehensively; the positioning device forms a basis for coordinate conversion in the whole instrument, converts the entity position into a digital coordinate and confirms the coordinate of the position of the pathological section; and providing data selection/reference basis for the scanning adjustment path of the final adjustment instrument.

The specific scan path operation is as follows: 1) the preparation method comprises the following steps: the pathological section is placed on a glass slide 9, the glass slide 9 is placed on an object stage 1, a scanning device and a positioning device are adjusted to be proper in height, whether the equipment normally operates or not is detected, and the follow-up operation is carried out after all the equipment is normal. 2) Image positioning: the photo of the objective table 1 is shot through the positioning device, the information is transmitted to the central processing unit, and the central processing unit adjusts the shooting range and selects a coordinate reference object through instructions to confirm the establishment of the origin of the coordinates, the x axis and the y axis. The z-axis coordinate is established by the up-down adjustment structure therein in combination with the position of the microscope. Determining the specific coordinate position of the pathological section by a positioning device, and dividing a scanning area; the scanning area is preferably rectangular or parallelogram in shape after positioning. 3) A focus searching step: adjusting the pathological section and the microscope position according to the scanning area obtained in the step 2). Specifically, in the z-axis direction, the scanning and collecting device 7 preliminarily obtains a first picture obtained through the microscope, controls a third motor on the z-axis to drive the microscope to move up by one unit, shoots a second picture observed by the microscope through the scanning and collecting device 7 again, transmits picture information to the central processing unit, and compares the definition of the two pictures through the central processing unit. If the definition of the first picture is larger than that of the second picture, the third motor drives the microscope to move downwards by one unit; if the definition of the second picture is equal to that of the first picture, the third motor drives the microscope to move one unit in the moving direction of one step of previous operation; if the definition of the second picture is larger than that of the first picture, the third motor drives the microscope to move upwards one unit continuously; taking the second picture as the first picture, taking the picture after shifting as the second picture, continuously comparing until the interval times with the same definition in two continuous times or the same definition in image contrast is one time, and judging to find the best shooting focus; 4) analyzing and confirming the scanning path: and selecting a scanning path according to the scanning area and the focus location obtained in the step 2) and the step 3). The path scan includes two paths, the first is a top-down scan as a whole, and each time the scan from left to right is completed before moving down. The second is that scanning is performed from left to right as a whole, and before each right scanning, it is necessary to ensure that scanning from top to bottom is completed. The device is used for shooting high-definition image information of a measured object in the direction of a z axis. And acquiring images of the measured object at different heights of each position. And the central processing unit sequences different definitions of the measured object at the same shooting position, and selects the clearest image information to perform subsequent image splicing. Wherein, the scanning camera is connected with the central processing unit and is used for collecting the histopathology information images. Conventional scanning, such as kohamamatsu photonics corporation, japan, such as patent No. TW108124608, is known to use a full scan of the stage for acquisition. 4) Scanning and shooting: the specific distance moved by each scanning ensures that the same part of the shot picture and the previous picture is more than 1/4, and the same part of the part at the same position is more than 1/4 during each line-feed or column-feed scanning. 5) Image splicing: the shot image information is transmitted to an upper computer by a central processing unit, the upper computer analyzes and processes image data, and the images are spliced into a complete scanning image. The information is transmitted to the ship-to terminal, and the image storage recording can be carried out by using a block chain technology (or a technology with a similar effect), so that the accuracy of the data is ensured. 6) An image analysis step: the image analysis is carried out through a neural network, the pathological tissues of the object to be detected are identified manually to form a model training set, then new pathological tissues are scanned and identified, the identification result is required to reach the identification of hundreds of pathological parts, the identification possibly comprises tissues without pathological parts, and the judgment is carried out subsequently by doctors. When the identification is carried out manually, corresponding operation data can be formed in each operation, the operation data and the image information after operation processing are stored in a database or stored in a block chain technology, the traceability and high accuracy of the data are ensured, and the positioning tracking can be effectively carried out when errors and problems occur, particularly which link has errors. The scanning collection of this equipment can be accomplished in 5 minutes, has greatly promoted scanning speed and efficiency, and traditional scanning scheme adopts and carries out comprehensive scanning to whole objective table compared, and its time-consuming far exceeds this scheme.

It is obvious that the described embodiments are only some of the embodiments of the present invention, and not all of them. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts shall belong to the protection scope of the present invention.

Claims (10)

1. A pathological section scanner which characterized in that: comprises a moving device, a positioning device, a scanning device, a light source (2) and an object stage (1) for placing pathological sections; the moving device can drive the object stage (1) to move in the horizontal direction, and when the object stage (1) moves to the position below the positioning device, the positioning device can acquire images of pathological sections so as to identify an initial position; when the objective table (1) moves to the lower part of the scanning device, the scanning device can carry out image acquisition and scanning on the pathological section.

2. The pathological section scanner according to claim 1, wherein: the light source (2) comprises a positioning light source (21) and a scanning light source (22), and the area of the positioning light source (21) is larger than that of the scanning light source (22).

3. The pathological section scanner according to claim 1, wherein: also comprises a base (10); the moving device comprises an X-axis moving device (3) and a Y-axis moving device (4), moving tracks of the Y-axis moving device (4) and the X-axis moving device (3) are perpendicular to each other, the X-axis moving device (3) is installed on the base (10), and the Y-axis moving device (4) is connected with the X-axis moving device (3) through a connecting plate (49).

4. The pathological section scanner according to claim 1, wherein: the objective table (1) comprises a mounting part (11), the mounting part (11) is provided with a mounting position (14) capable of placing the glass slide (9) and a limiting sheet (13) capable of limiting the movement of the glass slide (9), and the bottom surface of the mounting position (14) is a through groove (12) which can be penetrated by the light source (2).

5. The pathological section scanner according to claim 4, wherein: the glass slide rack is characterized by further comprising a rack (15), wherein an opening (16) capable of placing or taking out the glass slide (9) is formed in the rack (15), and the opening (16) and the mounting position (14) are on the same horizontal plane.

6. The pathological section scanner according to claim 1, wherein: the scanning device comprises a scanning acquisition device (7) and a Z-axis lifting device (5); the Z-axis lifting device (5) can control the scanning and collecting device (7) to ascend or descend in the vertical direction.

7. A pathological section scanner according to claim 3, wherein: the X-axis moving device (3) comprises an X-axis guide rail (31), an X-axis sensor (32), an X-axis power part (33), an X-axis moving part (34) and an X-axis switch (35) fixed on the X-axis moving part (34); the X-axis power part (33) can control the X-axis moving part (34) to move along the X-axis guide rail (31), and the X-axis sensor (32) and the X-axis switch (35) can control the X-axis moving part (34) to start or stop.

8. A pathological section scanner according to claim 3, wherein: the Y-axis moving device (4) comprises a Y-axis guide rail (41), a Y-axis sensor (42), a Y-axis power part (43), a Y-axis moving part (44), a Y-axis mounting plate (46) and a Y-axis switch (45) fixed on the Y-axis moving part (44); the Y-axis power part (43) can control the Y-axis moving part (44) to move along the Y-axis guide rail (41), the Y-axis sensor (42) and the Y-axis switch (45) can control the Y-axis moving part (44) to start or stop, and the Y-axis sensor (42) is fixed on the connecting plate (49) through the Y-axis mounting plate (46).

9. The pathological section scanner according to claim 6, wherein: the Z-axis lifting device (5) comprises a Z-axis driving part (51) and a Z-axis mounting part (52), the Z-axis mounting part (52) is used for mounting the scanning and collecting device (7), and the Z-axis driving part (51) can move in the vertical direction through the Z-axis mounting part (52).

10. The pathological section scanner according to claim 2, wherein: the positioning light source (21) is an LED light plate; the scanning light source (22) is an LED lamp.

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