CN218579990U - Cell factory culture sterility testing device and cell transfer device - Google Patents
Cell factory culture sterility testing device and cell transfer device Download PDFInfo
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- CN218579990U CN218579990U CN202222666951.5U CN202222666951U CN218579990U CN 218579990 U CN218579990 U CN 218579990U CN 202222666951 U CN202222666951 U CN 202222666951U CN 218579990 U CN218579990 U CN 218579990U
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- 238000013190 sterility testing Methods 0.000 title abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 46
- 238000001514 detection method Methods 0.000 claims abstract description 37
- 239000001963 growth medium Substances 0.000 claims abstract description 9
- 238000012360 testing method Methods 0.000 claims description 31
- 230000036512 infertility Effects 0.000 claims description 27
- 239000002609 medium Substances 0.000 claims description 12
- 239000012530 fluid Substances 0.000 claims description 8
- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 claims description 8
- 229940071127 thioglycolate Drugs 0.000 claims description 5
- 238000001125 extrusion Methods 0.000 claims description 4
- 239000002874 hemostatic agent Substances 0.000 claims description 3
- 238000005070 sampling Methods 0.000 description 14
- 239000000047 product Substances 0.000 description 12
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 11
- 208000015181 infectious disease Diseases 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 239000013067 intermediate product Substances 0.000 description 4
- 238000011065 in-situ storage Methods 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000004656 cell transport Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 238000012606 in vitro cell culture Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
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Abstract
The utility model discloses a sterile detection device for cell factory culture, which belongs to the field of medical instruments and comprises a liquid inlet pipe, a drip cup, a liquid outlet pipe and a culture bottle which are connected in sequence, wherein the sterile detection device can rapidly suck the culture in a cell factory into the drip cup by extruding the drip cup, extrude the culture in the drip cup into the culture bottle by extruding the drip cup again, and detect whether the culture is polluted by a sterile detection culture medium; the device novel structure is reasonable, links to each other with the liquid outlet of cell factory during the use, need not to carry the cell factory to detecting the place, can realize the normal position sample, and the aseptic detection device of cell factory culture passes through airtight pipeline and the inside intercommunication of cell factory moreover, need not to open the sample with the cell factory, and the security when having ensured the sample has effectively reduced because the sample of uncapping causes the risk that the culture infects in the cell factory. The utility model also provides a cell transfer device with above-mentioned cell factory culture sterility testing device.
Description
Technical Field
The utility model belongs to the field of medical equipment, relate to the cell detection technique, especially relate to a cell factory culture aseptic testing device and cell transfer device.
Background
The cell factory is a cell culture consumable with a multilayer structure and is mainly used for large-scale in-vitro cell culture. Cell factories are commonly used in the vaccine industry, and hundreds or thousands of cell factories are used in the same batch. The phenomenon that individual cell factories are polluted when cells are passaged or inoculated with viruses and harvested and combined occurs, once the cell factories which are polluted in the culture stage are combined into the same batch of products, the batch of products cannot pass through the sterility test, and finally the whole batch of products is discarded, so that great waste is caused.
At present, although sterility test can be performed on a culture in a cell factory during a culture stage, hundreds or thousands of cell factories need to be transported one by one to a test point, and after the test, the cell factories need to be transported back to a culture site one by one, so that a large number of the cell factories are transported back and forth, which consumes labor and wastes time. Moreover, when detecting the culture in each cell factory, the cover needs to be opened for sampling, the steps are complicated, and the culture in the cell factory is easily polluted during sampling, so that the hidden danger of product quality is caused.
Aiming at the defects of the existing cell factory sterile detection means, the utility model provides a novel device for carrying out sterile detection on cultures in cell factories.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a cell factory culture sterility testing device and cell transfer device, it need not to uncap, can carry out the normal position sample to the cell factory to reduce the transport number of times that the cell factory carried out sterility testing time and by uncapping the infection risk that the sample brought.
In order to achieve the above object, the utility model provides a following scheme:
the utility model provides a sterile detection device of cell factory culture, include:
the liquid inlet of the drip cup is connected with a liquid inlet pipe which is used for being connected with a liquid outlet of a cell factory, and the drip cup can suck the culture in the cell factory into the drip cup after being extruded;
the first switch controller is arranged on the liquid inlet pipe and used for controlling the opening and closing of the liquid inlet pipe;
the blake bottle, the blake bottle pass through the drain pipe with the liquid outlet of dripping the kettle links to each other, be provided with aseptic detection culture medium in the blake bottle, contain the culture drip kettle receive after the extrusion can with the culture is crowded into in the blake bottle, aseptic detection culture medium is used for detecting whether the culture is contaminated.
Optionally, the first switch controller is a valve or a flow controller.
Optionally, one end of the liquid outlet pipe is connected with the culture bottle, and the other end of the liquid outlet pipe is provided with a plastic plug which is connected with the drip cup in an inserting mode.
Optionally, the sterility test medium is a thioglycolate fluid medium.
And simultaneously, the utility model provides a cell transfer device, it includes the direct pipe of cell factory and as above arbitrary one the aseptic detection device of cell factory culture, the feed liquor pipe with the cell factory is directly established ties with a connecting line after the pipe is parallelly connected, the connecting line be used for with the liquid outlet of cell factory links to each other, the direct pipe of cell factory be used for with cell in the cell factory is transported and is merged to the product, be provided with the second switch controller that is used for controlling its switching on the direct pipe of cell factory, and works as when first switch controller is in the open mode, second switch controller is in the closed mode.
Optionally, the cell factory liquid feeding device further comprises a tee joint structure, two channels in the tee joint structure are respectively connected with the cell factory straight-through pipe and the liquid inlet pipe, and the remaining channel is connected with the connecting pipeline.
Optionally, the three-way structure is a three-way valve.
Optionally, the second switch controller is a hemostat or a valve.
The utility model discloses for prior art gain following technological effect:
the utility model provides a sterile detection device of cell factory culture, it links to each other through the liquid outlet of feed liquor pipe with the cell factory, makes the feed liquor pipe open through first switch controller, can inhale the drip cup rapidly through the culture of extrusion drip cup in with the cell factory in, then makes the feed liquor pipe close through first switch controller, extrudes the drip cup once more to in squeezing into the blake bottle with the inside culture of drip cup, detect whether the culture is contaminated through aseptic detection culture medium. The utility model has novel and reasonable structure, is connected with the liquid outlet of a cell factory during use, can realize in-situ sampling without carrying the cell factory to a detection place, and ensures the safety during sampling without opening the cell factory for sampling by communicating the sterile detection device of cell factory culture with the interior of the cell factory through a closed pipeline, thereby effectively reducing the risk of infection of the culture in the cell factory caused by uncapping sampling; in addition, owing to set up first on-off controller between drip chamber and cell factory, can keep apart cell factory inside and whole cell factory culture aseptic detection device when need not the sample after the drip chamber sample or, avoid cell factory inside to be polluted, improved the utility model discloses cell factory culture aseptic detection device's safety in utilization.
To sum up, the utility model discloses need not to uncap, can carry out the normal position sample to cell factory, reduced cell factory and carried the transport number of times that aseptic technique was surveyed to time measuring and the infection risk that brings by the sample of uncapping, be applicable to the aseptic technique of cell factory culture stage, can effectively avoid leading to merging the back wholesale intermediate product to be useless because of the contamination of individuality cell factory.
The utility model discloses the cell transfer device who has above-mentioned cell factory culture aseptic detection device who still provides, it specifically is a cell transfer device with cell aseptic detection function, wherein, feed liquor pipe among the cell factory culture aseptic detection device is parallelly connected with the direct pipe of cell factory that is used for merging the interior cell of transportation cell factory, and through the cooperation of second switch controller on the direct pipe of first switch controller on the feed liquor pipe and cell factory use, the switching of cell aseptic detection function and cell transfer function has been realized, can be before cell transportation merges, carry out aseptic detection to the culture in the cell factory through cell factory culture aseptic detection device, and need not to carry the cell factory among the testing process and open the lid to the cell factory and take a sample, wait to detect qualified back, can directly switch over to cell transfer function, merge the cell in the cell factory to the product. Above-mentioned cell transfer device novel structure is reasonable, and it can just carry out aseptic detection to the cell at cell factory culture stage to effectively avoid leading to merging back wholesale intermediate product to be useless because of cell factory infects the fungus.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a schematic structural view of a device for detecting sterility of a culture in a cell factory according to an embodiment of the present invention.
Wherein the reference numbers are: 1. a drip cup; 2. a liquid inlet pipe; 3. a cell factory; 4. a first switch controller; 5. a culture bottle; 6. a sterility test medium; 7. a liquid outlet pipe; 8. a plastic plug; 9. a cell factory straight tube; 10. connecting a pipeline; 11. a second switch controller; 12. an air filter.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
One of the purposes of the utility model is to provide a cell factory culture sterility testing device, it need not to uncap, can carry out the normal position sample to the cell factory to reduce the transport number of times that the cell factory carried out aseptic inspection time and the infection risk of bringing by the sample of uncapping.
The utility model also aims to provide a cell transfer device with the above cell factory culture sterility testing device.
In order to make the aforementioned objects, features and advantages of the present invention more comprehensible, the present invention is described in detail with reference to the accompanying drawings and the following detailed description.
Example one
As shown in fig. 1, this embodiment provides a cell factory culture sterility test apparatus, which mainly includes a liquid inlet tube 2, a drip cup 1, a liquid outlet tube 7 and a culture bottle 5, which are connected in sequence, wherein the liquid inlet tube 2 is used for connecting with the liquid outlet of a cell factory 3, and the drip cup 1 can be squeezed to suck the culture in the cell factory 3 into the drip cup 1; be provided with first switch controller 4 on feed liquor pipe 2, a switching for controlling feed liquor pipe 2, under the normal condition, when needing to carry out aseptic detection to the culture in the cell factory 3, first switch controller 4 opens feed liquor pipe 2, drip 1 and the inside intercommunication of cell factory 3, in order normally to take a sample to drip 1 in the cell factory 3, the sample finishes or need not carry out aseptic detection to the culture in the cell factory 3 during time measuring, first switch controller 4 closes feed liquor pipe 2, drip 1 and the inside non-intercommunication of cell factory 3 this moment. The sterile detection culture medium is arranged in the culture bottle 5, the squeezing drip cup 1 squeezes the culture in the culture bottle 5, and the sterile detection culture medium can detect whether the culture in the cell factory 3 is polluted.
In this embodiment, the drip cup 1 is a closed container made of rubber, is transparent, and can observe the amount of culture therein.
In this embodiment, the first switch controller 4 is a switch structure, which is preferably a valve or a flow controller. When the first switch controller 4 is a valve, it can be a manual valve or an electromagnetic valve; when the first switch controller 4 is a flow controller, a manually adjustable infusion flow controller or an electronic flow controller may be used.
In this embodiment, one end of the liquid outlet pipe 7 is connected with the culture bottle 5, and the other end is provided with a plastic plug 8 to be inserted into the drip cup 1, so that the drip cup 1 and the liquid outlet pipe 7 can be conveniently connected and detached.
In this embodiment, the sterility test medium 6 is preferably a thioglycolate fluid medium, and when the culture inside the chamber is squeezed into the culture bottle 5 by squeezing the drip cup 1, the culture is in contact with the thioglycolate fluid medium, and if the thioglycolate fluid medium generates a turbidity phenomenon, the culture is proved to be polluted, and the corresponding cell factory 3 should not be incorporated into the same batch of products; on the contrary, if the thioglycollate fluid medium does not produce turbidity, it is proved that the culture is not contaminated, and the corresponding cell factory 3 is safe and can be incorporated into the same batch of products according to the normal flow.
Therefore, the cell factory culture sterility testing device that this technical scheme provided, it links to each other through the liquid outlet of feed liquor pipe with the cell factory, makes the feed liquor pipe open through first on-off controller, can inhale the drip cup rapidly through the culture of extrusion drip cup in with the cell factory in, then makes the feed liquor pipe close through first on-off controller, extrudes the drip cup once more to in squeezing into the blake bottle with the inside culture of drip cup, detect whether the culture is contaminated through aseptic detection culture medium. The cell factory culture sterility test device is novel and reasonable in structure, is connected with a liquid outlet of a cell factory during use, can realize in-situ sampling without carrying the cell factory to a test site, is communicated with the interior of the cell factory through a closed pipeline, does not need to open the cell factory for sampling, ensures the safety during sampling, and effectively reduces the risk of infection of a culture in the cell factory due to uncapping sampling; in addition, because set up first on-off controller between drip chamber and cell factory, can be after the drip chamber sample or need not to keep apart the cell factory inside with whole cell factory culture aseptic detection device when taking a sample, avoid the cell factory inside to be polluted, improved cell factory culture aseptic detection device's safety in utilization.
In conclusion, the cell factory culture sterility test device provided by the technical scheme can be used for sampling the cell factory in situ without opening a cover, reduces the carrying times of the cell factory in sterility test and the infection risk caused by opening the cover for sampling, is suitable for sterility test in the cell factory culture stage, and can effectively avoid the waste of the whole batch of intermediate products after combination due to contamination of individual cell factories.
Example two
As shown in fig. 1, the present embodiment provides a cell transfer device, which includes a cell factory straight-through tube 9 and a cell factory culture sterility test device as in the first embodiment, a liquid inlet tube 2 of the cell factory culture sterility test device and the cell factory straight-through tube 9 are connected in parallel and then connected in series with a connecting tube 10, the connecting tube 10 is used for connecting with a liquid outlet of the cell factory 3, the cell factory straight-through tube 9 is used for transferring and combining cells in the cell factory 3 into a product, the cell factory straight-through tube 9 is provided with a second switch controller 11 for controlling the on-off of the cell factory straight-through tube, and when the first switch controller 4 is in an open state, the second switch controller 11 is in a closed state.
In this embodiment, the device further comprises a three-way structure, two channels of the three-way structure are respectively connected with the cell factory straight-through pipe 9 and the liquid inlet pipe 2, and the remaining channel is connected with the connecting pipeline 10. The three-way structure is a three-way valve.
In this embodiment, the second switch controller 11 is a switch structure, which can be a hemostat or a valve.
In this embodiment, an air filter 12 is further disposed on the cell factory 3 to provide a clean culture environment in the cell factory 3. The installation of the air filter 12 on the cell factory 3 is conventional in the art and will not be described in detail here.
The principle of the cell transport device of this embodiment will be described in detail below.
When in use, the cell factory straight-through pipe 9 is firstly connected into one channel of the three-way valve, and the other two channels of the three-way valve are respectively connected with the liquid inlet pipe 2 of the cell factory culture sterility detection device and the liquid outlet of the cell factory 3 in the embodiment I. When sampling detection is required in the cell factory 3, the cell factory straight-through pipe 9 is closed by the hemostatic forceps (namely, the second switch controller), the liquid inlet pipe 2 is opened by the first switch controller 4, the drip cup 1 is pinched flat to suck the culture (generally liquid) in the cell factory 3 into the drip cup 1, the liquid inlet pipe 2 is closed by the first switch controller 4, and the drip cup 1 is pressed again to press the culture into the culture bottle 5. The culture is contacted with a thioglycollate fluid medium, which if turbid results, it is established that the culture is contaminated and the corresponding cell factory 3 should not be incorporated into the same batch of product; on the contrary, if the thioglycollate fluid medium does not produce turbidity, it is proved that the culture is not contaminated, and the corresponding cell factory 3 is safe and can be incorporated into the same batch of products according to the normal flow.
Therefore, the cell transfer device with the cell factory culture sterility test device provided by the technical scheme is particularly a cell transfer device with a cell sterility test function, a liquid inlet pipe in the cell factory culture sterility test device is connected with a cell factory straight-through pipe for merging and transferring cells in a cell factory in parallel, the cell sterility test function and the cell transfer function are switched through the cooperation of a first switch controller on the liquid inlet pipe and a second switch controller on the cell factory straight-through pipe, the cell factory culture sterility test device can be used for carrying out sterility test on the cultures in the cell factory before cell transfer and combination, the cell factory does not need to be carried and the cell factory is uncovered for sampling in the test process, and the cell transfer function can be directly switched to after the cells in the cell factory are qualified to be tested, so that the cells in the cell factory are merged into a product. Above-mentioned cell transfer device novel structure is reasonable, and it can just carry out aseptic detection to the cell at cell factory culture stage to effectively avoid leading to merging back wholesale intermediate product to be useless because of cell factory infects the fungus.
In actual operation, the whole set of cell factory culture sterility test device can be irradiated and sterilized firstly, and then is connected with a three-way valve. The cell transfer device can be used for performing sterile detection on cell culture after passage and supernatant and seed virus, and is simple and convenient to operate.
It should be noted that, as is obvious to a person skilled in the art, the invention is not limited to details of the above-described exemplary embodiments, but can be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein, and any reference signs in the claims are not to be construed as limiting the claim concerned.
The utility model discloses a concrete example is applied to explain the principle and the implementation mode of the utility model, and the explanation of the above example is only used to help understand the method and the core idea of the utility model; meanwhile, for those skilled in the art, the idea of the present invention may be changed in the specific embodiments and the application range. In summary, the content of the present specification should not be construed as a limitation of the present invention.
Claims (8)
1. A cell factory culture sterility test device, comprising:
the liquid inlet of the drip cup is connected with a liquid inlet pipe which is used for being connected with a liquid outlet of a cell factory, and the drip cup can suck the culture in the cell factory into the drip cup after being extruded;
the first switch controller is arranged on the liquid inlet pipe and used for controlling the opening and closing of the liquid inlet pipe;
the blake bottle, the blake bottle pass through the drain pipe with the liquid outlet of dripping the kettle links to each other, be provided with aseptic detection culture medium in the blake bottle, contain the culture drip kettle receive after the extrusion can with the culture is crowded into in the blake bottle, aseptic detection culture medium is used for detecting whether the culture is contaminated.
2. The cell factory culture sterility test device according to claim 1, wherein the first switch controller is a valve or a flow controller.
3. The apparatus for testing sterility of cell factory culture according to claim 1, wherein one end of said liquid outlet tube is connected to said culture bottle, and the other end is provided with a plastic plug for plugging said drip cup.
4. The device for the sterility test of cell factory cultures according to claim 1, characterized in that the sterility test medium is a thioglycolate fluid medium.
5. A cell transfer device, comprising a cell factory flow-through tube and the cell factory culture sterility test device according to any one of claims 1 to 4, wherein the liquid inlet tube and the cell factory flow-through tube are connected in parallel and then connected in series with a connecting tube, the connecting tube is used for connecting with a liquid outlet of the cell factory, the cell factory flow-through tube is used for transferring and combining cells in the cell factory into a product, the cell factory flow-through tube is provided with a second switch controller for controlling the opening and closing of the cell factory flow-through tube, and when the first switch controller is in an open state, the second switch controller is in a closed state.
6. The cell transfer device according to claim 5, further comprising a tee structure, two channels of which are connected to the cell factory straight-through tube and the liquid inlet tube, respectively, and the remaining one channel is connected to the connecting line.
7. The cell transfer device of claim 6, wherein the three-way structure is a three-way valve.
8. The cell transfer device of claim 5, wherein the second switch controller is a hemostat or a valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222666951.5U CN218579990U (en) | 2022-10-10 | 2022-10-10 | Cell factory culture sterility testing device and cell transfer device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222666951.5U CN218579990U (en) | 2022-10-10 | 2022-10-10 | Cell factory culture sterility testing device and cell transfer device |
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| Publication Number | Publication Date |
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| CN218579990U true CN218579990U (en) | 2023-03-07 |
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| CN202222666951.5U Active CN218579990U (en) | 2022-10-10 | 2022-10-10 | Cell factory culture sterility testing device and cell transfer device |
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| CN (1) | CN218579990U (en) |
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- 2022-10-10 CN CN202222666951.5U patent/CN218579990U/en active Active
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| GR01 | Patent grant | ||
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Address after: No. 819, drug City Avenue, Taizhou, Jiangsu Province, Jiangsu Patentee after: Aimei Action Biopharmaceutical Co.,Ltd. Address before: No. 819, drug City Avenue, Taizhou, Jiangsu Province, Jiangsu Patentee before: AIMEI CONVAC BIO-PHARMACY (JIANGSU) Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder |