CN217821368U - Temperature control device and bioreactor - Google Patents
Temperature control device and bioreactor Download PDFInfo
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- CN217821368U CN217821368U CN202222345801.4U CN202222345801U CN217821368U CN 217821368 U CN217821368 U CN 217821368U CN 202222345801 U CN202222345801 U CN 202222345801U CN 217821368 U CN217821368 U CN 217821368U
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Abstract
The utility model provides a temperature control device for the temperature of the control reactor jar body, its characterized in that: the temperature control device comprises a heat conduction cup used for accommodating the reactor tank body, a semiconductor piece in contact with the bottom of the heat conduction cup, a radiating fin connected with the semiconductor piece and a radiating fan used for radiating the radiating fin, wherein refrigerant liquid is filled between the heat conduction cup and the reactor tank body. The utility model discloses a temperature control device, through heat conduction cup with be equipped with refrigerant liquid between the reactor jar body to can improve temperature control device with the heat exchange efficiency of the reactor jar body.
Description
Technical Field
The utility model relates to a temperature control device and bioreactor.
Background
The bioreactor is an essential device for culturing microorganisms or cells, and can provide a suitable reaction environment for the growth and metabolism of the microorganisms or the cells and promote the proliferation or production of the cells. Temperature control is a very important factor in different bioprocess control processes, and different microorganisms or cells are greatly influenced by temperature during culture, so that the growth and the product yield are directly influenced.
The temperature control method of the conventional bioreactor is realized by adopting a sandwich type refrigerant exchange mode, auxiliary equipment such as a water cooler and the like needs to be additionally arranged in the using process, the occupied space of the equipment is larger, and the phenomena of leakage, leakage and the like of a circulating medium pipeline need to be noticed all the time in the culturing process, so that the time and the labor are wasted. For the micro-bioreactor, because of the limitation of the operation space, the traditional sandwich type coolant exchange mode is not very suitable.
There are also anhydrous (liquid) semiconductor temperature control devices for micro-bioreactor applications, relying on the contact surface between the tank and the cold cup for heat transfer. However, due to the problems of machining precision, surface finish, and the like, the contact area is insufficient, air exists between the two parts, the overall heat transfer coefficient is greatly reduced, the efficiency is low, and particularly, the problem is more serious because the tolerance of the glass tank body is generally large. To alleviate this, it is generally necessary to increase the height of the cold cup, which in turn affects the view of the interior of the can body.
In view of the above, there is a need for an improved temperature control device to solve the above problems.
Disclosure of Invention
An object of the utility model is to provide a temperature control device to solve the poor problem of current bioreactor heat conduction effect.
In order to achieve the above object, the present invention provides a temperature control device for controlling the temperature of the reactor tank, the temperature control device comprises a heat conducting cup for accommodating the reactor tank, a semiconductor member contacting with the bottom of the heat conducting cup, a heat radiating fin connected with the semiconductor member, a heat radiating fan for radiating the heat radiating fin, wherein a coolant liquid is filled between the heat conducting cup and the reactor tank.
As a further improvement of the utility model, the side wall of the heat conducting cup is provided with an opening extending downwards from the top.
As a further improvement of the utility model, the temperature control device further comprises a sealing element, the sealing element is arranged the heat conduction cup with between the reactor jar body, and encircle open-ended both sides and below to prevent refrigerant liquid from following the opening flows out.
As a further improvement of the present invention, the number of the openings and the sealing members is two, and the openings are disposed on two opposite sides of the heat conducting cup.
As a further improvement of the utility model, the opening is U-shaped.
As a further improvement of the present invention, the temperature control device further comprises a heat insulating pad surrounding the semiconductor member, the heat insulating pad is disposed between the heat conducting cup and the heat radiating fins.
As a further improvement of the utility model, the temperature control device further comprises a heat insulation sheath arranged outside the heat conduction cup.
As a further improvement of the present invention, the bottom of the heat conducting cup is provided with a heat conducting contact platform, the heat conducting contact platform contacts with the semiconductor member, so as to transfer heat in the heat conducting cup to the semiconductor member.
As a further improvement, the temperature control device further comprises a bracket base surrounding the cooling fan, and the cooling holes are formed in the two opposite sides of the horizontal direction of the bracket base.
The utility model also provides a bioreactor, the bioreactor includes the reactor jar body, as above-mentioned temperature control device.
The beneficial effects of the utility model are that: the utility model discloses a bioreactor and temperature control device through heat conduction cup with be equipped with refrigerant liquid between the reactor jar body to can improve temperature control device with the heat exchange efficiency of the reactor jar body.
Drawings
FIG. 1 is a schematic diagram of the structure of a bioreactor of the present invention;
FIG. 2 is a schematic view of the exploded structure of the bioreactor of the present invention;
FIG. 3 is a schematic view of the exploded structure of the bioreactor of the present invention;
FIG. 4 is a schematic structural view of a heat conducting cup of the temperature control device of the present invention;
FIG. 5 is a schematic structural view of the heat conducting cup of the temperature control device according to another direction of the present invention;
FIG. 6 is a schematic structural view of a heat conducting cup and a heat insulating sheath of the temperature control device of the present invention;
fig. 7 is a schematic structural diagram of a bracket base of the temperature control device of the present invention.
Detailed Description
The technical solution of the present invention will be described clearly and completely with reference to the accompanying drawings, and obviously, the described embodiments are some, but not all embodiments of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts all belong to the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art. Furthermore, the technical features mentioned in the different embodiments of the invention described below can be combined with each other as long as they do not conflict with each other.
As shown in fig. 1 to 7, the bioreactor 100 of the present invention includes a reactor tank 1 and a temperature control device 2. The temperature control device 2 is used for controlling the temperature of the reactor tank 1.
As shown in fig. 1 to 3, the temperature control device 2 includes a heat conducting cup 21 for receiving the reactor tank 1, a sealing member, a heat insulating sheath 23 disposed outside the heat conducting cup 21, a semiconductor member 24 contacting with the bottom of the heat conducting cup 21, a heat insulating pad 25 disposed around the semiconductor member 24, a heat sink 26 connected to the semiconductor member 24, a heat dissipating fan 27 for dissipating heat from the heat sink 26, and a support base 28 disposed around the heat dissipating fan 27.
And a refrigerant liquid is filled between the heat conducting cup 21 and the reactor tank body 1. The coolant liquid can improve the heat exchange coefficient, thereby fully transferring the heat in the reactor tank body 1 to the heat conducting cup 21. The refrigerant liquid can be one or two of water, sodium dodecyl sulfate solution and ethanol solution. The addition of the refrigerant liquid can remove the gas between the heat conducting cup 21 and the reactor tank body 1 and improve the mass transfer coefficient.
As shown in fig. 4 to 6, the heat conducting cup 21 is made of aluminum metal with better heat conducting property, so as to better transfer heat. The heat insulation sheath 23 is made of nylon polyester with excellent heat insulation performance, and the heat insulation sheath 23 can effectively prevent heat loss of the heat conduction cold cup.
The bottom of the heat conducting cup 21 is provided with a heat conducting contact platform 213, and the side wall of the heat conducting cup 21 is provided with an opening 211 extending from top to bottom.
The thermally conductive contact pad 213 is in contact with the semiconductor 24 to transfer heat from the thermally conductive cup 21 to the semiconductor 24 for heat dissipation. The heat conducting contact platform 213 can better transfer heat and improve heat exchange efficiency.
The opening 211 is U-shaped. The opening 211 can be used as a window for observing the reaction condition in the reactor tank 1.
The sealing member is disposed between the heat conducting cup 21 and the reactor tank 1 and surrounds both sides and below the opening 211 to prevent the refrigerant liquid from flowing out of the opening 211. In this embodiment, the inner wall of the heat conducting cup 21 is provided with a groove 212 for installing a sealing member. When the reactor tank 1 is housed in the heat-conducting cup 21, the seal member is held between the reactor tank 1 and the heat-conducting cup 21, thereby preventing the refrigerant liquid from flowing out through the opening 211.
When the reactor tank 1 is not placed in the heat-conducting cup 21, the coolant liquid is lower than the opening 211, so that the coolant liquid is prevented from overflowing, and when the reactor tank 1 is accommodated in the heat-conducting cup 21, the coolant liquid is higher than the lower end of the opening 211, so that the sealing piece can prevent the coolant liquid from flowing out.
In this embodiment, the number of the openings 211 and the sealing members is two, and two openings 211 are disposed on opposite sides of the heat conducting cup 21.
As shown in fig. 1 to 3, the semiconductor device 24 in this embodiment is a peltier element, and can perform cooling or heating control through circuit conduction.
The heat insulating pad 25 is disposed between the heat conducting cup 21 and the heat sink 26 to prevent heat from escaping from the side of the semiconductor element 24. The heat insulation pad 25 is made of nylon material with excellent heat insulation performance.
The heat sink 26 is made of aluminum with excellent heat conductivity to improve the heat exchange effect.
The top of the heat dissipation fan 27 is attached to the heat dissipation plate 26, so that heat obtained by heat exchange on the heat dissipation plate 26 can be quickly transferred and dissipated.
As shown in fig. 7, the holder base 28 is a rectangular three-dimensional hollow structure, and the upper end surface thereof is provided with a circular limiting groove 281 for limiting and fixing the heat insulating pad 25 and the heat conducting cup 21.
A rectangular hole 282 is formed in the middle of the circular limiting groove 281 in the bottom of the support, and the rectangular hole can be embedded into the heat-conducting contact platform 213 protruding from the bottom of the heat-conducting cup 21, so that the heat-conducting contact platform can perform effective heat exchange with the semiconductor component 24.
Heat dissipation holes 283 are opened on two opposite sides of the bracket base 28 in the horizontal direction. The heat dissipation hole 283 facilitates the heat dissipation fan 27 to quickly dissipate the exchanged heat.
The bioreactor 100 and the temperature control device 2 of the utility model can improve the heat exchange efficiency of the temperature control device 2 and the reactor tank body 1 by arranging the refrigerant liquid between the heat conducting cup 21 and the reactor tank body 1; the opening 211 is formed in the heat conducting cup 21, so that the state in the reactor tank 1 can be observed conveniently.
All possible combinations of the technical features of the above embodiments may not be described for the sake of brevity, but should be considered as within the scope of the present disclosure as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only represent some embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the concept of the present invention, several variations and modifications can be made, which all fall within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.
Claims (10)
1. The utility model provides a temperature control device for the temperature of control reactor jar body, its characterized in that: the temperature control device comprises a heat conduction cup used for accommodating the reactor tank body, a semiconductor piece in contact with the bottom of the heat conduction cup, a heat dissipation fin connected with the semiconductor piece and a heat dissipation fan used for dissipating heat of the heat dissipation fin, and refrigerant liquid is filled between the heat conduction cup and the reactor tank body.
2. The temperature control apparatus according to claim 1, characterized in that: the side wall of the heat conducting cup is provided with an opening extending from top to bottom.
3. The temperature control apparatus according to claim 2, characterized in that: the temperature control device also comprises a sealing piece which is arranged between the heat conducting cup and the reactor tank body and surrounds the two sides and the lower part of the opening so as to prevent the refrigerant liquid from flowing out of the opening.
4. The temperature control apparatus according to claim 3, wherein: the number of the openings and the sealing parts is two, and the two openings are arranged on two opposite sides of the heat conducting cup.
5. The temperature control apparatus according to claim 4, wherein: the opening is U-shaped.
6. The temperature control apparatus according to claim 1, characterized in that: the temperature control device also includes a thermal pad disposed around the semiconductor member, the thermal pad disposed between the thermally conductive cup and the heat sink.
7. The temperature control apparatus according to claim 1, characterized in that: the temperature control device also comprises a heat insulation sheath arranged on the outer side of the heat conduction cup.
8. The temperature control apparatus according to claim 1, characterized in that: and the bottom of the heat conducting cup is provided with a heat conducting contact platform, and the heat conducting contact platform is in contact with the semiconductor piece so as to transfer heat in the heat conducting cup to the semiconductor piece.
9. The temperature control apparatus according to claim 1, characterized in that: the temperature control device further comprises a support base surrounding the cooling fan, and cooling holes are formed in two opposite sides of the support base in the horizontal direction.
10. A bioreactor, characterized by: the bioreactor comprises a reactor tank, a temperature control device as claimed in any one of claims 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222345801.4U CN217821368U (en) | 2022-09-05 | 2022-09-05 | Temperature control device and bioreactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222345801.4U CN217821368U (en) | 2022-09-05 | 2022-09-05 | Temperature control device and bioreactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217821368U true CN217821368U (en) | 2022-11-15 |
Family
ID=83975951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222345801.4U Active CN217821368U (en) | 2022-09-05 | 2022-09-05 | Temperature control device and bioreactor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN217821368U (en) |
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2022
- 2022-09-05 CN CN202222345801.4U patent/CN217821368U/en active Active
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