CN217605874U - Quantitative interpretation device for immunochromatographic test paper - Google Patents
Quantitative interpretation device for immunochromatographic test paper Download PDFInfo
- Publication number
- CN217605874U CN217605874U CN202221292015.6U CN202221292015U CN217605874U CN 217605874 U CN217605874 U CN 217605874U CN 202221292015 U CN202221292015 U CN 202221292015U CN 217605874 U CN217605874 U CN 217605874U
- Authority
- CN
- China
- Prior art keywords
- immunochromatographic test
- light source
- light
- test strip
- test paper
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The utility model relates to an immunoassay technical field specifically discloses a device is explained to immunochromatography test paper ration. The device includes: the immunochromatographic test paper test device comprises an immunochromatographic test paper slot, a light source transmitting module, a receiving module, a driving mechanism and a main control unit; the light source emission module includes: the device comprises a light source generator with variable intensity and a slit, wherein exciting light forms a rectangular light spot through the slit, the rectangular light spot is emitted to the immunochromatography test strip and is reflected to a receiving module; the receiving module converts the exciting light into a digital signal; the driving mechanism is connected with the immunochromatographic test strip slot and drives the immunochromatographic test strip slot to move; and the main control unit is connected with the light source transmitting module, the receiving module and the driving mechanism, and realizes the adjustment of the intensity of the light source, the interpretation of the digital signal and the action control of the driving mechanism. The utility model discloses optical signal scanning based on rectangle facula and dichroscope can be very big reduces light field background light and disturbs, and coupling capacitance's application can effectively eliminate the temperature drift of the signal of telecommunication, and variable light intensity's light source has promoted the signal and has explained the ability.
Description
Technical Field
The utility model relates to an immunoassay technical field especially relates to immunochromatography test paper detection technology field.
Background
As one of the most successful immunodetection platforms for commercial application, the lateral immunochromatographic test strip has the unique advantages of easiness in storage, convenience in carrying, intuitive signal response and easiness in field development, and is increasingly applied to the fields of forbidden drug monitoring, biological safety, food additive monitoring, disease diagnosis, agricultural production and the like.
With the application and development of the mechanical processing and software programming technology in the immunochromatography detection technical field, the research and development of a device for realizing the quantitative interpretation of response signals become one of the important contents of the development of the field, and the development is towards miniaturization, portability and intellectualization.
The common quantitative interpretation device for the miniaturized immunochromatographic test paper collects the surface images of the test paper under the excitation of a single light source, and realizes quantitative interpretation based on gray level analysis. The defects of the detection platform in practical application mainly include the following aspects:
1. a joint inspection test paper for simultaneously carrying out signal quantitative analysis on multiple targets does not have a matched interpretation device;
2. the collected optical signals are easily interfered by stray light of an optical field and the temperature drift of the electric signals of the photodiode is easily caused at different working temperatures;
3. the constant light source intensity limits the appropriate light source intensity required by different detection targets and further limits the signal interpretation range.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is: aiming at the defects of the existing signal interpretation technology, the scanning type multi-channel immunochromatographic test paper signal interpretation device with the variable light source intensity is provided. The device has the characteristics that the number of light sources is matched with the number of channels, signal scanning is carried out based on rectangular light spots, different excitation light intensities are adopted in different signal acquisition regions, and coupling capacitors are matched behind photodiodes so as to eliminate temperature drift.
In order to solve the technical problem, the utility model discloses the technical scheme who adopts is: an immunochromatographic test strip quantitative interpretation device, comprising: the immunochromatographic test paper test device comprises an immunochromatographic test paper slot, a light source transmitting module, a receiving module, a driving mechanism and a main control unit;
the immunochromatographic test paper slot is used for accommodating an immunochromatographic test paper strip;
a light source emission module comprising: the device comprises a light source generator with variable intensity and a slit, wherein excitation light emitted by the light source generator with variable intensity can form a rectangular light spot through the slit to irradiate the immunochromatography test strip, and the immunochromatography test strip reflects the excitation light to the receiving module;
the receiving module is used for converting the received exciting light into a digital signal corresponding to the light intensity;
the driving mechanism is connected with the immunochromatographic test strip slot and can drive the immunochromatographic test strip slot to move in the signal acquisition region of the light source emission module;
and the main control unit is connected with the light source emitting module, the receiving module and the driving mechanism, and realizes the light source intensity adjustment of the light source generator with variable intensity, the interpretation of the digital signals obtained by the receiving module and the action control of the driving mechanism.
Preferably, the light source emitting module is further provided with a dichroic mirror, excitation light emitted by the light source generator with variable intensity is emitted to the immunochromatographic test strip through reflection of the dichroic mirror after passing through the slit, the immunochromatographic test strip reflects the excitation light to the dichroic mirror, and the excitation light reflected by the immunochromatographic test strip is transmitted to the receiving module through transmission of the dichroic mirror.
Preferably, a first lens and a first optical filter are further arranged between the slit and the dichroscope, and the excitation light emitted by the light source generator with variable intensity forms a first rectangular light spot through the slit, the first lens and the first optical filter;
a third lens is arranged between the dichroic mirror and the immunochromatographic test strip, and the rectangular light spot is reflected by the dichroic mirror and then is focused by the third lens to be converted into a second rectangular light spot irradiated on the immunochromatographic test strip;
and a second optical filter and a second lens are also arranged between the dichromatic mirror and the receiving module, and the rectangular light spot II is reflected by the immunochromatography test strip, focused by the third lens, transmitted by the dichromatic mirror, and then passes through the second optical filter and the second lens to generate a rectangular light spot III which is then transmitted to the receiving module.
Preferably, the receiving module includes: the photodiode is used for receiving the exciting light reflected by the immunochromatographic test strip, and the coupling capacitor is arranged behind the photodiode.
Preferably, the variable intensity light source generator employs an LED lamp.
Preferably, the immunochromatographic test strip slot is a two-channel immunochromatographic test strip slot and is used for accommodating two immunochromatographic test strips; the variable intensity light source generator is a dual channel variable intensity light source generator.
The utility model has the advantages that:
1. a matched interpretation device is provided for joint inspection test paper which needs to perform signal quantitative analysis on multiple targets simultaneously;
2. optical signal scanning based on the rectangular light spots and the dichroscope can greatly reduce light field background light interference and can effectively eliminate temperature drift of an electric signal by using a coupling capacitor;
3. the light source with variable light intensity improves the signal interpretation capability of the device.
Drawings
Fig. 1 is a schematic diagram of an embodiment of the quantitative interpretation device for immunochromatographic test paper according to the present invention.
Description of the labeling:
1 … dual-channel immunochromatographic test strip slot, 2 … immunochromatographic test strip, 3 … signal acquisition zone, 4 … light source emission module, 5 … light source generator, 6 … slit, 7 … receiving module, 8 … rectangular spot one, 9 … driving mechanism, 10 … main control unit, 11 … two-phase, 12 … photodiode, 13 … coupling capacitor, 14 … lens one, 15 … optical filter one, 16 … lens three, 17 rectangular 34 zxft 3734 rectangular spot two, 18 … optical filter two, 5819 zxft 3552, 3575 three optical filter 35xft 3575.
Detailed Description
Preferred embodiments of the present invention will be described in more detail below. While the following describes preferred embodiments of the present invention, it should be understood that the present invention may be embodied in various forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
As shown in fig. 1, an embodiment of the quantitative interpretation device for immunochromatographic test paper provided by the present invention includes: the device comprises a double-channel immunochromatographic test paper slot 1, a light source emitting module 4, a receiving module 7, a driving mechanism 9 and a main control unit 10.
The double-channel immunochromatographic test strip slot 1 is used for accommodating two immunochromatographic test strips 2 and is arranged in a signal acquisition area 3 of the light source emission module 4 during signal acquisition.
Light source emission module 4, comprising: the light source generator 5 with the variable intensity and the slit 6 are provided with two channels, exciting light emitted by the light source generator 5 with the variable intensity can form a rectangular light spot I8 through the slit 6 and shoot to the immunochromatographic test strip 2, and the exciting light reflected by the immunochromatographic test strip 2 is transmitted to the receiving module 7.
The receiving module 7 is used for converting the received exciting light into a digital signal corresponding to the light intensity.
The driving mechanism 9 is connected with the dual-channel immunochromatographic test strip slot 1 and is used for driving the dual-channel immunochromatographic test strip slot 1 to move in the signal acquisition region 3 of the light source emission module 4;
and the main control unit 10 is connected with the light source emitting module 4, the receiving module 7 and the driving mechanism 9, and is used for realizing light source intensity adjustment of the light source generator 5 with variable intensity, interpretation of the digital signals obtained by the receiving module 7 and action control of the driving mechanism 9.
Specifically, two immunochromatographic test strips 2 are accommodated in a double-channel immunochromatographic test strip slot 1, and are arranged in a signal acquisition region 3 of a light source emission module 4 during signal acquisition; setting the intensity change modes of the two light sources through the main control unit 10 according to the specific conditions of the test strip, and performing scanning detection on the immunochromatographic test strip 2 by using the appropriate light source intensity; in the detection process, the two light source generators 5 can respectively form a rectangular light spot I8 through the slit 6 to emit exciting light to the immunochromatographic test strip 2, the exciting light reflected by the immunochromatographic test strip 2 is respectively received by the two receiving modules 7, and is analyzed and detected by the main control unit 10. Meanwhile, the driving mechanism 9 can drive the dual-channel immunochromatographic test paper slot 1 to move in the signal acquisition region 3, so that scanning detection of the dual-channel immunochromatographic test paper 2 is realized.
In some embodiments, the light source may be any light source capable of exciting the immunochromatographic test strip to generate reflected light, such as visible light, fluorescence, laser, etc., so as to achieve high-sensitivity detection.
In some embodiments, the light source emitting module 4 is further provided with a dichroic mirror, two light paths generated by the two light source generators 5 with variable intensities pass through the slit 6 and then are reflected by the two dichroic mirrors 11 to the immunochromatographic test strip 2, and then excitation light reflected by the immunochromatographic test strip 2 is transmitted to the receiving module 7 through transmission of the dichroic mirror 11, so that interference of stray light is reduced, and detection sensitivity is improved.
As shown in fig. 1, in some embodiments, a first lens 14 and a first filter 15 are further disposed between the slit 6 and the dichroic mirror 11 in the light path portion of the light source emitting module 4, and the excitation light emitted by the variable-intensity light source generator 5 forms a rectangular light spot first 8 through the slit 6, the first lens 14 and the first filter 15;
a lens III 16 is further arranged between the dichromatic mirror 11 and the immunochromatographic test strip 2, and the rectangular light spot I8 is reflected by the dichromatic mirror 11 and then is focused by the lens III 16 to be converted into a rectangular light spot II 17 with the diameter of 1.5 x 3mm irradiated on the immunochromatographic test strip;
a second optical filter 18 and a second lens 19 are further arranged between the dichromatic mirror 11 and the receiving module 7, and excitation light reflected by the immunochromatographic test strip 2 is focused by a third lens 16, transmitted by the dichromatic mirror 11, passes through the second optical filter 18 and the second lens 19 to generate a 2 x 2mm rectangular light spot three 20 and is transmitted to the receiving module 7.
In some embodiments, the receiving module 7 includes a photodiode 12 and a coupling capacitor 13, the photodiode 12 is used for receiving the excitation light reflected by the immunochromatographic strip, and the photodiode 12 and the coupling capacitor 13 are electrically connected. The coupling capacitor 13 is arranged behind the photodiode 12. The coupling capacitor 13 is used to isolate the dc signal and let the ac signal pass through, so as to solve the problem of signal temperature drift (i.e. the change of the leakage current of the photodiode due to the change of the ambient temperature). The instrument detects the magnitude of the alternating current signal, and even if the leakage current of the photodiode is increased due to the change of the external environment, the direct current voltage is increased, so that the accuracy of detected data cannot be influenced.
In some embodiments, the variable intensity light source generator employs an LED lamp.
While various embodiments of the present invention have been described above, the above description is intended to be illustrative, not exhaustive, and not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments.
Claims (6)
1. The utility model provides an immunity chromatography test paper ration interpretation device which characterized in that, it includes: the immunochromatographic test paper test device comprises an immunochromatographic test paper slot, a light source transmitting module, a receiving module, a driving mechanism and a main control unit;
the immunochromatographic test paper slot is used for accommodating an immunochromatographic test paper strip;
the light source emission module includes: the device comprises a light source generator with variable intensity and a slit, wherein excitation light emitted by the light source generator with variable intensity can form a rectangular light spot through the slit to irradiate the immunochromatography test strip, and the immunochromatography test strip reflects the excitation light to the receiving module;
the receiving module is used for converting the received exciting light into a digital signal corresponding to the light intensity;
the driving mechanism is connected with the immunochromatographic test strip slot and can drive the immunochromatographic test strip slot to move in the signal acquisition area of the light source emission module;
the main control unit is connected with the light source emitting module, the receiving module and the driving mechanism, and realizes the light source intensity adjustment of the light source generator with variable intensity, the interpretation of the digital signals obtained by the receiving module and the action control of the driving mechanism.
2. The quantitative interpretation device for immunochromatographic test paper according to claim 1, wherein a dichroic mirror is further provided in the light source emission module, excitation light emitted by the light source generator with variable intensity is emitted to the immunochromatographic test paper strip through reflection of the dichroic mirror after passing through the slit, the immunochromatographic test paper strip reflects the excitation light to the dichroic mirror, and the excitation light reflected by the immunochromatographic test paper strip is transmitted to the receiving module through transmission of the dichroic mirror.
3. The quantitative identification device of immunochromatographic test strip according to claim 1,
a first lens and a first optical filter are arranged between the slit and the dichroic mirror, and the exciting light emitted by the light source generator with variable intensity forms a first rectangular light spot through the slit, the first lens and the first optical filter;
a third lens is further arranged between the dichroic mirror and the immunochromatographic test strip, and the rectangular light spot is reflected by the dichroic mirror and then is focused by the third lens to be converted into a second rectangular light spot irradiated onto the immunochromatographic test strip;
and a second optical filter and a second lens are also arranged between the dichroscope and the receiving module, and the second rectangular light spot is reflected by the immunochromatography test strip, focused by the third lens, transmitted by the dichroscope, and then generated by the second optical filter and the second lens to be transmitted to the receiving module.
4. The quantitative interpretation apparatus for immunochromatographic test strip according to claim 1, 2 or 3, wherein said receiving means comprises: the photoelectric diode is used for receiving the exciting light reflected by the immunochromatographic test strip, and the coupling capacitor is arranged behind the photoelectric diode.
5. The quantitative interpretation apparatus for immunochromatographic test strip according to claim 1, 2 or 3, wherein said light source generator with variable intensity is an LED lamp.
6. The quantitative identification device of immunochromatographic test strip according to claim 1, 2 or 3,
the immunochromatographic test paper slot is a two-channel immunochromatographic test paper slot and is used for accommodating two immunochromatographic test paper strips;
the variable intensity light source generator is a dual channel variable intensity light source generator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221292015.6U CN217605874U (en) | 2022-05-23 | 2022-05-23 | Quantitative interpretation device for immunochromatographic test paper |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221292015.6U CN217605874U (en) | 2022-05-23 | 2022-05-23 | Quantitative interpretation device for immunochromatographic test paper |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217605874U true CN217605874U (en) | 2022-10-18 |
Family
ID=83587159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202221292015.6U Active CN217605874U (en) | 2022-05-23 | 2022-05-23 | Quantitative interpretation device for immunochromatographic test paper |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN217605874U (en) |
-
2022
- 2022-05-23 CN CN202221292015.6U patent/CN217605874U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2173014C (en) | Fiber optic diffuse light reflectance sensor | |
| US5780857A (en) | Apparatus for imaging biochemical samples on substrates | |
| JP3515646B2 (en) | Multi-capillary electrophoresis device | |
| CA1291345C (en) | Fluorescence detection apparatus for immunoassay | |
| CN108181290B (en) | Fluorescent quantitative analyzer | |
| US8605147B2 (en) | Device for recording images of an object scene | |
| CN100526883C (en) | Reflection photometer of gold-labeled immunity test paper strip | |
| JP2008536092A (en) | Fluorescence detection system | |
| KR20180041688A (en) | Multi-excitation-multi-emission fluorescence spectrometer for multi-parameter water quality monitoring | |
| CN110487767B (en) | Portable up-conversion fluorescence detector | |
| JP6703215B1 (en) | Optical measuring device and optical measuring method | |
| CN112748245A (en) | Multi-channel fluorescence immunochromatography quantitative detector and detection method thereof | |
| CN217605874U (en) | Quantitative interpretation device for immunochromatographic test paper | |
| CN105866075A (en) | Fluorescence detection apparatus | |
| CN2938080Y (en) | Reflection photometer of gold-labeled immunity test paper strip | |
| CN210803281U (en) | Special detection equipment for lateral flow immunochromatography based on near-infrared two-zone fluorescence imaging | |
| CN116602617A (en) | Optical fiber recording system | |
| US20080144009A1 (en) | System and method for removing auto-fluorescence through the use of multiple detection channels | |
| CN211061419U (en) | Optical system and detector | |
| CN108982431B (en) | On-line fluorescence detection device | |
| CN112630204A (en) | Hand-held fluorescence detector | |
| WO2022026053A1 (en) | Multiplexed sensor network using swept source raman spectroscopy | |
| CN214408690U (en) | Hand-held fluorescence detector | |
| CN215115886U (en) | Optical measuring device | |
| WO2020005430A1 (en) | Integrated pre-amplification light detection systems and methods of use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder |
Address after: Room 1402, Unit 2, Floor 14, Building 1, No. 20, Yong'an Road, Shilong Economic Development Zone, Mentougou District, Beijing 102300 DXF395 Patentee after: Beijing Nordhuakang Medical Technology Co.,Ltd. Address before: 100067 Room 207, Building 14, Jiayuan Yili, Fengtai District, Beijing Patentee before: Beijing Nordhuakang Medical Technology Co.,Ltd. |
|
| CP02 | Change in the address of a patent holder |