CN210803281U - Special detection equipment for lateral flow immunochromatography based on near-infrared two-zone fluorescence imaging - Google Patents
Special detection equipment for lateral flow immunochromatography based on near-infrared two-zone fluorescence imaging Download PDFInfo
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- CN210803281U CN210803281U CN201921466072.XU CN201921466072U CN210803281U CN 210803281 U CN210803281 U CN 210803281U CN 201921466072 U CN201921466072 U CN 201921466072U CN 210803281 U CN210803281 U CN 210803281U
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Abstract
The utility model provides a special lateral flow immunochromatography detection device based on near-infrared two-zone fluorescence imaging, which comprises a frame, a test strip transmission and fixing device and a fluorescence excitation and imaging device; the frame is used for integrating the test strip transmission and fixing device and the fluorescence excitation and imaging device; the test strip transmission and fixing device is used for transmitting the test strip to the observation position of the fluorescence excitation and imaging device; the fluorescence excitation and imaging device is used for emitting infrared excitation light to the test strip and capturing the near infrared two-region fluorescence generated by the infrared excitation light for imaging; the fluorescence excitation and imaging device comprises an infrared light source, a near-infrared camera and a dichroic mirror; the light emitting direction of the infrared light source is vertical to the light sensing direction of the near-infrared camera and is positioned in the same light path plane; the dichroic mirror is arranged in the light path plane and is positioned at the intersection point of the light emitting direction and the light sensing direction. The utility model discloses a special check out test set can effectively utilize two district fluorescence imaging principles of near-infrared to improve the sensitivity that the lateral flow immunochromatography detected, has extensive application prospect.
Description
Technical Field
The utility model relates to a side direction flows immunochromatography check out test set based on two district fluorescence imaging of near-infrared.
Background
The lateral flow fluorescence immunochromatography technology is a novel detection technology developed and innovated by combining the immunofluorescence technology and the traditional immunochromatography technology, has the advantages of simple and convenient operation, rapid detection, strong portability and high sensitivity, is suitable for quantitative detection, and is widely applied to the important fields of clinical diagnosis, environmental monitoring, food safety and the like of infectious diseases, cardiovascular diseases, infection and other diseases. The markers for lateral flow fluorescence immunochromatography detection mainly comprise fluorescent protein, fluorescent compounds, fluorescent microspheres, quantum dots and the like, and at present, most of the markers are excited by ultraviolet light and detected by red light. However, blood samples, nitrocellulose membranes, paper strip back plates, and the like are prone to generate background fluorescence near the wavelength of the emitted light of the markers under excitation of excitation light, and certain interference is generated in detection. Therefore, in the current lateral flow fluorescence immunochromatography technology, the detection sensitivity reaches the upper limit, and is difficult to further improve.
Fluorescence imaging is an important biomedical imaging means, and has high imaging speed and high sensitivity. A common fluorescence imaging method is near-infrared one-zone imaging (with emission wavelength of 750-900 nanometers), but has the problems of high background interference (tissue autofluorescence), high tissue self-absorption and high scattering, small penetration depth, incapability of deep-layer tissue imaging and the like. The near-infrared two-region fluorescent probe (NIR-II, 1000-1700 nm) has higher spatial-temporal resolution and deeper imaging depth in biological tissue imaging due to longer emission wavelength and less interference of light scattering and tissue autofluorescence, is a research hotspot in the field of molecular imaging at present, and may have wide application prospects in the aspects of in-vivo surgical navigation, in-vivo deep tissue high-resolution fluorescence imaging, lymph node imaging, tumor optical imaging and the like, but the application of the near-infrared two-region fluorescent probe in lateral flow fluorescence immunochromatography detection is not reported.
Therefore, in order to further improve the detection sensitivity of lateral flow immunofluorescence chromatography in the prior art, it is necessary to combine the near infrared two-zone fluorescence imaging with the lateral flow immunochromatography detection, and a new special detection device is developed to promote the application of the near infrared two-zone imaging in the lateral flow immunochromatography detection.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a special check out test set of side direction flow immunochromatography based on two district fluorescence imaging of near-infrared, this equipment can effectively utilize two district fluorescence imaging principles of near-infrared to improve the sensitivity that side direction flow immunochromatography detected.
The above object of the utility model is realized through following technical scheme:
providing a special lateral flow immunochromatography detection device based on near-infrared two-region fluorescence imaging, wherein the device at least comprises a frame, a test strip transmission and fixing device and a fluorescence excitation and imaging device;
the frame is used for integrating the test strip transmission and fixing device and the fluorescence excitation and imaging device;
the test strip conveying and fixing device is used for conveying the lateral flow immunochromatographic test strip to the observation position of the fluorescence excitation and imaging device and fixing the lateral flow immunochromatographic test strip;
the fluorescence excitation and imaging device is used for emitting infrared excitation light to the lateral flow immunochromatographic test strip which is conveyed and fixed and capturing the near infrared two-region fluorescence generated thereby for imaging; the fluorescence excitation and imaging device at least comprises an infrared light source, a near-infrared camera and a dichroic mirror; the light emitting direction of the infrared light source is perpendicular to the light sensing direction of the near-infrared camera and is positioned in the same light path plane; the dichroic mirror is arranged in the light path plane and is positioned at the intersection point of the light emitting direction and the light sensing direction; the light path plane is vertical to the plane where the lateral flow immunochromatographic strip is fixed, and the light emitting direction or the light sensing direction is in the same straight line with the chromatographic membrane on the lateral flow immunochromatographic strip.
Special check out test set in, the light source be the LED light source of near infrared light of wavelength about can launching 800 nm.
In the scheme of the utility model, the test strip which can be used for the special detection equipment is a lateral flow immunochromatography test strip which comprises a bottom lining plate, and a sample pad, a marker pad, a chromatographic membrane and a water absorption pad which are sequentially arranged on the bottom lining plate along the length of the bottom lining plate, wherein the chromatographic membrane is provided with detection lines and quality control lines at intervals; wherein, a near-infrared two-region fluorescent probe is fixed on the marker pad, and the near-infrared two-region fluorescent probe is an antigen A or an antibody A marked by a near-infrared two-region fluorescent substance; the detection line is coated with an antigen B or an antibody B which is different from the recognition site of the antigen A or the antibody A; and the quality control line is coated with a calibration antigen C or an antibody C. The lateral flow immunochromatographic strip can be prepared by a conventional method and then fixed by a strip fixing plate with a dosing hole and a chromatographic membrane window for later use.
In the special detection device of the utility model, the specific structure of the frame is not limited; the test strip conveying and fixing device and the fluorescence excitation and imaging device can be used for the detection equipment of the utility model as long as the test strip conveying and fixing device and the fluorescence excitation and imaging device can be reasonably and integrally installed; the reasonable meaning is that the positions of the test strip transmission and fixing device and the fluorescence excitation and imaging device can be properly arranged, so that the transmitted and fixed test strip can be accurately excited by the fluorescence excitation and imaging device and can be observed and imaged. For example, after the fluorescence excitation and imaging device and the test strip transmission and fixing device are integrally mounted on the frame, they may be vertically stacked or horizontally stacked.
The concrete structure of examination strip conveying and fixing device also is not restricted, as long as can carry the examination strip and be fixed in fluorescence arouses and imaging device's suitable observation position's structure, all can be used for the check out test set, for example examination strip conveying and fixing device can be installed the frame with the fluorescence arouses the mechanism that slide and slider are constituteed in the semi-open space that imaging device constitutes, also can be by embedded in spout in the frame and can be in the mechanism that gliding examination strip mounting panel is constituteed in the spout.
In a preferred embodiment of the present invention, the special detecting device comprises a frame, a test strip transmitting and fixing device, and a fluorescence exciting and imaging device; the frame comprises a bottom plate arranged horizontally and a vertical wall vertically arranged at one end of the bottom plate; the fluorescence excitation and imaging device is arranged at the top end of the vertical wall and is suspended above the bottom plate, and the fluorescence excitation and imaging device, the vertical wall and the bottom plate form a detection cabin together; the test strip transmission and fixing device is arranged between the bottom plate and the fluorescence excitation and imaging device and comprises a pair of slide ways which are horizontally arranged, a slide block which is arranged on the slide ways and a test strip fixing plate which is fixedly arranged on the upper surface of the slide block; the slide way penetrates through the inside and the outside of the detection cabin, and the test strip fixing plate can slide back and forth on the slide way through the slide block, so that the test strip can enter and exit from the detection cabin; the fluorescence excitation and imaging device at least comprises an infrared light source, a near-infrared camera and a dichroic mirror; the light emitting direction of the infrared light source is set to be horizontal, the light sensing direction of the near-infrared camera is vertical and upward, and the dichroic mirror is arranged at the intersection of the light emitting direction and the light sensing direction; the slide way is provided with a limiting device, so that a chromatographic film on the test strip is positioned under the dichroic mirror after the test strip fixing plate enters the detection cabin and is positioned on the same vertical line with the near-infrared camera and the dichroic mirror.
Adopt special check out test set examines time measuring, gets the examination strip fixed plate of examination strip after being fixed with the reaction, promotes through manpower or automatic actuating mechanism the examination strip fixed plate follow the slide slides in the detection cabin. After the chromatographic membrane part of the test strip enters the observation position of the fluorescence excitation and imaging device, starting the light source to emit infrared excitation light with the wavelength of about 800nm, and reflecting the excitation light by the dichroic mirror and vertically transmitting the excitation light downwards to reach the chromatographic membrane of the test strip; the antigen A marked by the near-infrared two-region fluorescent substance captured on the detection line and/or the quality control line on the chromatographic membrane emits a near-infrared two-region fluorescent signal under excitation of excitation light, and the near-infrared two-region fluorescent signal vertically upwards propagates through the dichroic mirror to reach the near-infrared camera photosensitive position, namely is captured and imaged by the near-infrared camera.
In another preferred embodiment of the present invention, the special detecting device comprises a frame, a test strip transmitting and fixing device, and a fluorescence exciting and imaging device; the frame comprises a bottom plate, and a test strip conveying cabin and a detection equipment cabin which are stacked on the bottom plate from bottom to top; the middle part of any side surface of the test strip conveying cabin is provided with an inward sunken slot as a test strip conveying and fixing device, the inner side wall of the slot is provided with a pair of slideways for inserting the test strip from an inlet of the slot through a test strip fixing plate and sliding along the slideways, so that the test strip can pass in and out of the test strip conveying cabin, and the far end of the slideway is provided with a limiting device; the fluorescence excitation and imaging device is arranged in the detection equipment cabin and at least comprises an infrared light source, a near-infrared camera and a dichroic mirror; the light emitting direction of the infrared light source is set to be horizontal, the light sensing direction of the near-infrared camera is vertical and upward, and the dichroic mirror is arranged at the intersection of the light emitting direction and the light sensing direction; the limiting device of the slideway ensures that the chromatographic film on the test strip is positioned under the dichroic mirror after the test strip fixing plate enters the test strip delivery cabin and is positioned on the same vertical line with the near-infrared camera and the dichroic mirror.
In order to control the wavelength of the exciting light that reachs the examination strip more accurately and prevent to collect the long wave the near-infrared camera produces the interference, the utility model discloses in the preferred scheme the light source with the dichroic mirror between further be equipped with the short wave pass filter along the light path direction to reject the exciting light of 1000nm above wavelength.
In order to more accurately control the wavelength of the light captured by the infrared camera and improve the imaging quality, in the preferred scheme of the utility model, a long-wave pass filter is further arranged between the dichroic mirror and the near-infrared camera to eliminate the interference generated by the near-infrared fluorescence with short wavelength; more preferably, a pair of plano-convex lenses are arranged between the long-wave pass filter and the near-infrared camera at intervals along the light path direction, the plano-convex lenses are opposite in convex surface and respectively used as a condenser lens and a collimator lens to focus the visual field of the test strip on the near-infrared camera, and the near-infrared two-zone fluorescence is guaranteed to be captured by the near-infrared camera as far as possible.
In a more preferred embodiment of the present invention, the dichroic mirror and the test strip further have a plano-convex lens between them, the plano-convex lens having a convex surface facing the test strip, and the plano-convex lens is used for gathering the exciting light onto the chromatographic membrane of the test strip, and simultaneously transmitting the fluorescent light to the dichroic mirror along a straight line.
In an implementation mode of the special detection equipment, the special detection equipment is further provided with a display screen with a power supply component, the display screen pass through a data line and the near-infrared camera is electrically connected for receiving and displaying a fluorescence imaging result from the near-infrared camera. The display screen can be arranged at any position of the outer surface of the special detection equipment.
In another embodiment of special check out test set, fluorescence arouse and imaging device still be equipped with wireless transmission module for transmit fluorescence imaging result to outside receiving terminal through wireless mode, outside receiving terminal can be mobile terminal, for example cell-phone, mobile PC and so on.
In the preferred special detection device of the utility model, the near infrared camera is a near infrared camera with a sensitive wave band of 1000-1700 nm; most preferably an indium gallium arsenide camera with a sensitive band of 1000-1700 nm.
In the special check out test set, the parameter of long wave pass filter can be according to the wavelength of the fluorescent material transmission of mark on the examination strip selects, the utility model discloses in the preferred scheme, long wave pass filter be accessible wavelength and be greater than 1100 nanometers or 1500 nanometers's long wave pass filter.
In the existing fluorescence immunochromatography technology, the wave band of the emitted light of the used fluorescence marker is generally red light, the wavelength is not more than 900 nanometers, the fluorescence penetrability is not strong, the background fluorescence of samples and the like interferes the detection, and the detection sensitivity is difficult to improve. The utility model discloses an usable near-infrared two district fluorescence imaging of equipment, carry out the side direction flow immunodetection to the determinand, because the emission optical wavelength of near-infrared two district fluorescence probes is longer, the penetrating power is strong, simultaneously because the side direction flows material for immunochromatography detection, detect the sample etc. and do not produce background fluorescence basically more than 1000nm wavelength, make the detection background extremely low, thereby use near-infrared two district fluorescence probes as the sensitivity that the promotion that the side direction flows fluorescence immunochromatography detection can be very big to detect, can realize the high sensitive external detection of determinand, and the device has important meaning.
Drawings
Fig. 1 is a schematic view of the overall structure of the dedicated device according to embodiment 1 of the present invention.
Fig. 2 is a schematic side sectional structure view of the special device according to embodiment 1 of the present invention.
Detailed Description
The present invention will be further explained with reference to the following examples.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be implemented in other ways different from the specific details set forth herein, and one skilled in the art may similarly generalize the present invention without departing from the spirit of the present invention, and therefore the present invention is not limited to the specific embodiments disclosed below.
Next, the present invention will be described in detail with reference to the schematic drawings, and in the detailed description of the embodiments of the present invention, for convenience of illustration, the sectional views showing the structure of the device will not be enlarged partially according to the general scale, and the schematic drawings are only examples, and should not limit the scope of the present invention. In addition, the three-dimensional dimensions of length, width and depth should be included in the actual fabrication.
Example 1.
The special equipment for lateral flow immunochromatography detection by utilizing near infrared two-region fluorescence imaging structurally comprises a bottom plate 10, a test strip conveying cabin 20, a detection equipment cabin 30 and a display screen 40. As shown in fig. 1 and 2, a test strip transfer chamber 20 is fixedly mounted on the bottom plate 10, a detection device chamber 30 is mounted at one end of the top of the test strip transfer chamber 20, and a display screen 40 with a power supply component is fixedly mounted at the other end; the middle part of one side of the test strip transfer chamber 20 is provided with an inward concave slot 21, the inner side wall of the slot 21 is provided with a pair of slide ways 22, a test strip fixing plate 23 with a test strip fixed inside can be inserted from the inlet of the slot 21 and slides along the slide ways 22, so that the test strip can pass in and out of the test strip transfer chamber 20, and the far end of each slide way 22 is provided with a limiting device for fixing the test strip fixing plate 23 at a proper position. The detection chamber 30 is internally provided with a light path channel, and the light path channel is internally provided with a plurality of optical components to form a light path structure, specifically comprising an LED lamp 31 with the light-emitting wavelength being more than or equal to 800nm, an InGaAs camera 32 with the sensitive wave band being 1000-5 nm and a dichroic mirror 33; the light emitting direction of the LED lamp 31 is set to be horizontal, the light sensing direction of the indium gallium arsenic camera 32 is vertical and upward, and the dichroic mirror 33 is arranged at the intersection of the light emitting direction and the light sensing direction; a short-wave pass filter 34 is further arranged between the LED lamp 31 and the dichroic mirror 33 along the light path direction, and a long-wave pass filter 35, a first plano-convex lens 36 and a second plano-convex lens 37 are further sequentially arranged between the dichroic mirror 33 and the indium gallium arsenic camera 32 along the light path direction; the first plano-convex lens 36 and the second plano-convex lens 37 have convex surfaces facing each other and function as a condenser lens and a collimator lens on the optical path, respectively.
The limiting device of the slide way 22 can ensure that the nitrocellulose membrane 4 on the test strip is positioned right below the dichroic mirror 33 and is positioned on the same vertical line with the indium gallium arsenic camera 32 and the dichroic mirror 33, a third plano-convex lens 38 is arranged between the dichroic mirror 33 and the test strip fixing plate 23, the convex surface of the third plano-convex lens 38 is arranged downwards, and the third plano-convex lens is used for focusing the light propagating downwards onto the nitrocellulose membrane 4 and collimating the light propagating upwards.
The display screen 40 is electrically connected to the indium gallium arsenide camera 32 through a data line, and is used for receiving and displaying the fluorescence imaging result from the indium gallium arsenide camera 32. The detection device chamber 30 is further provided with a wireless transmission module (not shown in the drawings) for wirelessly transmitting the fluorescence imaging result to an external receiving end, which may be a mobile terminal, such as a mobile phone, a mobile PC, and the like.
When the special detection device of this embodiment is used for detection, the test strip fixing plate 23 on which the test strip after reaction is fixed is taken, and the test strip fixing plate 23 is pushed by a manual or automatic driving mechanism to slide into a proper position below the detection device chamber 30 along the slide way 22. After the nitrocellulose membrane 4 of the test strip enters a position right below the optical path of the detection equipment compartment 30, the LED lamp 31 is started to emit infrared excitation light with a wavelength of about 800nm, the excitation light is transmitted along the horizontal direction, the short-wave pass filter 34 eliminates the light with a long wavelength, the light is reflected by the dichroic mirror 33, and the light is vertically condensed downwards by the third plano-convex lens 38 and then is concentrated to the nitrocellulose membrane 4 of the test strip; the SAA monoclonal antibody marked by PbS captured on the detection line and/or the quality control line on the nitrocellulose membrane 4 can emit a near-infrared two-zone fluorescence signal under the excitation of excitation light, the near-infrared two-zone fluorescence signal is vertically and upwards collimated by a third plano-convex lens 38, then passes through a dichroic mirror 33, eliminates short-wavelength near-infrared fluorescence by a long-wave pass optical filter 35, and sequentially passes through the condensation and collimation treatment of a first plano-convex lens 36 and a second plano-convex lens 37, so that the test strip visual field is focused to an indium gallium arsenic camera 32, and the near-infrared two-zone fluorescence is captured and imaged by the indium gallium arsenic camera 32 as far as possible.
Claims (9)
1. A special detection equipment of lateral flow immunochromatography based on near-infrared two-zone fluorescence imaging is characterized in that: the device at least comprises a frame, a test strip transmission and fixing device and a fluorescence excitation and imaging device; the frame is used for integrating the test strip transmission and fixing device and the fluorescence excitation and imaging device; the test strip transmission and fixing device is used for transmitting the lateral flow immunochromatographic test strip to the observation position of the fluorescence excitation and imaging device and fixing the lateral flow immunochromatographic test strip; the fluorescence excitation and imaging device is used for emitting infrared excitation light to the lateral flow immunochromatographic test strip which is conveyed and fixed and capturing the near infrared two-region fluorescence generated thereby for imaging; the fluorescence excitation and imaging device at least comprises an infrared light source, a near-infrared camera and a dichroic mirror; the light emitting direction of the infrared light source is perpendicular to the light sensing direction of the near-infrared camera and is positioned in the same light path plane; the dichroic mirror is arranged in the light path plane and is positioned at the intersection point of the light emitting direction and the light sensing direction; the light path plane is vertical to the plane where the lateral flow immunochromatographic strip is fixed, and the light emitting direction or the light sensing direction is in the same straight line with the chromatographic membrane on the lateral flow immunochromatographic strip.
2. A special detection equipment of lateral flow immunochromatography based on near-infrared two-zone fluorescence imaging is characterized in that: the special detection equipment comprises a frame, a test strip transmission and fixing device and a fluorescence excitation and imaging device; the frame comprises a bottom plate, and a test strip conveying cabin and a detection equipment cabin which are stacked on the bottom plate from bottom to top; the middle part of any side surface of the test strip conveying cabin is provided with an inward sunken slot as a test strip conveying and fixing device, the inner side wall of the slot is provided with a pair of slideways for inserting the lateral flow immunochromatographic test strip from the inlet of the slot through the test strip fixing plate and sliding along the slideways, so that the lateral flow immunochromatographic test strip can pass in and out of the test strip conveying cabin, and the far end of each slideway is provided with a limiting device; the fluorescence excitation and imaging device is arranged in the detection equipment cabin and at least comprises an infrared light source, a near-infrared camera and a dichroic mirror; the light emitting direction of the infrared light source is set to be horizontal, the light sensing direction of the near-infrared camera is vertical and upward, and the dichroic mirror is arranged at the intersection of the light emitting direction and the light sensing direction; the limiting device of the slideway ensures that the chromatographic film on the test strip is positioned under the dichroic mirror after the test strip fixing plate enters the test strip delivery cabin and is positioned on the same vertical line with the near-infrared camera and the dichroic mirror.
3. The dedicated detection device according to any one of claims 1 or 2, characterized in that: and a short-wave pass filter is further arranged between the light source and the dichroic mirror along the direction of the light path.
4. The dedicated detection device according to any one of claims 1 or 2, characterized in that: and a long-wave pass filter, a condenser and a collimator are further sequentially arranged between the dichroic mirror and the near-infrared camera along the direction of the light path.
5. The dedicated detection device according to any one of claims 1 or 2, characterized in that: the special detection equipment is also provided with a display screen with a power supply component, and the display screen is electrically connected with the near-infrared camera through a data line and is used for receiving and displaying a fluorescence imaging result from the near-infrared camera.
6. The dedicated detection device according to any one of claims 1 or 2, characterized in that: the fluorescence excitation and imaging device is also provided with a wireless transmission module used for transmitting fluorescence imaging results to an external receiving end in a wireless mode, and the external receiving end is a movable terminal.
7. The dedicated detection device according to any one of claims 1 or 2, characterized in that: the light source is an LED light source capable of emitting near infrared light with the wavelength of 800 nm.
8. The dedicated detection device according to any one of claims 1 or 2, characterized in that: the near-infrared camera is a near-infrared camera with a sensitive waveband of 1000-1700 nm.
9. The dedicated detection device according to any one of claims 1 or 2, characterized in that: the near-infrared camera is an indium gallium arsenic camera with the sensitive wave band of 1000-1700 nanometers.
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| CN201921466072.XU CN210803281U (en) | 2019-09-03 | 2019-09-03 | Special detection equipment for lateral flow immunochromatography based on near-infrared two-zone fluorescence imaging |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110455766A (en) * | 2019-09-03 | 2019-11-15 | 莎穆(上海)生物科技有限公司 | Detection method based on two area's fluorescence imaging of near-infrared for the strip of lateral flow immune detection, detection device and non-diagnostic purpose |
| CN113049554A (en) * | 2021-03-11 | 2021-06-29 | 吉林大学第一医院 | Near-infrared two-region biological sample imaging device and biological sample imaging method |
-
2019
- 2019-09-03 CN CN201921466072.XU patent/CN210803281U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110455766A (en) * | 2019-09-03 | 2019-11-15 | 莎穆(上海)生物科技有限公司 | Detection method based on two area's fluorescence imaging of near-infrared for the strip of lateral flow immune detection, detection device and non-diagnostic purpose |
| CN113049554A (en) * | 2021-03-11 | 2021-06-29 | 吉林大学第一医院 | Near-infrared two-region biological sample imaging device and biological sample imaging method |
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