CN217212404U - Biochemical analyzer - Google Patents

Biochemical analyzer Download PDF

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Publication number
CN217212404U
CN217212404U CN202221631012.0U CN202221631012U CN217212404U CN 217212404 U CN217212404 U CN 217212404U CN 202221631012 U CN202221631012 U CN 202221631012U CN 217212404 U CN217212404 U CN 217212404U
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China
Prior art keywords
pump
liquid
sample
cup
cleaning
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CN202221631012.0U
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Chinese (zh)
Inventor
张海英
徐海明
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Shenzhen Xierman Technology Co ltd
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Shenzhen Xierman Technology Co ltd
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Abstract

The application provides a biochemical analyzer, including the biochemical analyzer includes: a body; a sample holder; the sample adding system comprises a sampling needle and a driving mechanism for driving the sampling needle to move; the device comprises a plurality of reaction detection systems, a plurality of detection units and a control unit, wherein each reaction detection system comprises a reactor with a reaction cavity, and a detector for detecting and analyzing a sample is arranged on the side edge of each reactor; the ion detection system comprises a sample adding cup for adding a sample and an ion concentration testing module; and the cleaning system comprises a cleaning cup for the sampling needle to extend into for cleaning. The application provides a biochemical analyzer, through integrated a plurality of reaction detecting system and ion detection system in the organism, through the content of a plurality of components of a plurality of reaction detecting system detection analysis sample, through ion concentration in the ion detection system detection sample to realize the detection and analysis of the multiple components of sample, with reduce analysis appearance kind quantity, reduce cost need not the partial shipment sample, and is efficient, can reduce the quantity of sample moreover.

Description

Biochemical analyzer
Technical Field
The application belongs to the technical field of biochemical analysis, and particularly relates to a biochemical analyzer.
Background
In biochemical analysis, such as analysis of samples, e.g., blood, cell culture fluids, etc., it is often necessary to detect the amount of a particular component in a sample. Most of the current biochemical analyzers can only carry out biochemical analysis on one or two specific components. However, in the biochemical analysis, a plurality of components of the sample need to be detected and analyzed, which requires a plurality of types of biochemical analyzers, the cost is high, the sample needs to be divided into a plurality of parts, and the parts are respectively placed in different types of biochemical analyzers for detection, the efficiency is low, and the sample amount in each biochemical analyzer is enough, and each part of the sample also needs to have certain redundancy, and the sample amount is large.
SUMMERY OF THE UTILITY MODEL
An object of the embodiment of the application is to provide a biochemical analyzer, so that the problems that in the prior art, when a plurality of components of a sample are subjected to biochemical analysis, the biochemical analyzer is required to be of multiple types, the required sample amount is large, and the detection efficiency is low are solved.
In order to achieve the above purpose, the embodiment of the present application adopts the following technical solutions: provided is a biochemical analyzer including:
a body;
a sample holder configured to store a reagent tube, the sample holder being mounted on the body;
the sample adding system comprises a sampling needle and a driving mechanism for driving the sampling needle to move, and the driving mechanism is arranged on the machine body;
a plurality of reaction detection systems, each reaction detection system comprising a reactor having a reaction chamber, a detector mounted to a side of each reactor for detecting an analyte sample, each reactor being mounted in the body;
the ion detection system comprises a sample adding cup and an ion concentration testing module, wherein the sample adding cup is used for adding a sample, the ion concentration testing module is used for detecting the ion concentration in the sample, the sample adding cup is communicated with the ion concentration testing module, and the sample adding cup and the ion concentration testing module are installed in the machine body; and the number of the first and second groups,
the cleaning system is configured to clean the sampling needle and comprises a cleaning cup used for enabling the sampling needle to extend into the body for cleaning, and the cleaning cup is installed in the body.
In an optional embodiment, the biochemical analyzer further comprises a dilution system for diluting the sample, the dilution system comprising a dilution cup, and a dilution pump set for supplying a dilution liquid into the dilution cup and for evacuating a liquid in the dilution cup, the dilution cup being mounted in the body.
In an optional embodiment, a dilution chamber is arranged in the dilution cup, and an overflow channel for discharging excess liquid in the dilution chamber, an emptying channel for emptying liquid in the dilution chamber and a liquid filling channel for filling diluent into the dilution chamber are arranged on the dilution cup.
In an optional embodiment, the driving mechanism comprises a bracket mounted in the machine body, a swing arm supporting the sampling needle, a support rod supporting the swing arm, a lifting driving module driving the support rod to lift and a rotating driving module driving the support rod to rotate, the lifting driving module and the rotating driving module are both mounted on the bracket, and the support rod is movably mounted on the bracket; the sample frame, the plurality of reactors, the sample adding cup and the cleaning cup are arranged around the support rod.
In an alternative embodiment, the biochemical analyzer further comprises:
a standard liquid supply system configured to supply a standard liquid for calibrating each of the detectors; the standard liquid supply system comprises a standard liquid cup used for collecting the standard liquid by the sampling needle, and the standard liquid cup is arranged in the machine body.
In an optional embodiment, the standard solution cup is provided with a plurality of standard solution cavities and a recovery cavity for collecting liquid overflowing from each standard solution cavity, the standard solution cavities correspond to the reactors one by one, and the standard solution supply system further comprises a standard solution pump set for pumping standard solution into each standard solution cavity and for emptying the liquid in the recovery cavity.
In an optional embodiment, a cleaning cavity is arranged in the cleaning cup, and the cleaning system further comprises a cleaning pump group for pumping cleaning liquid into the cleaning cavity and for emptying the liquid in the cleaning cavity.
In an optional embodiment, the sample adding system comprises a plunger pump for controlling sample adding of the sampling needle, and a washing pump for pumping washing liquid to the sampling needle; the inlet of the flushing pump is used for being connected with a cleaning liquid source, the outlet of the flushing pump is communicated with the inlet of the plunger pump, and the outlet of the plunger pump is communicated with the sampling needle.
In an optional embodiment, each of the reaction detection systems further comprises a reaction detection pump set for pumping a substrate solution into the reaction chamber and for evacuating the reaction chamber.
In an optional embodiment, the ion detection system further includes a discharge pump for discharging liquid in the sample cup, a bidirectional driving pump, and a flow path distribution module for controlling the multiple media sources to be respectively communicated with the bidirectional driving pump, and two ends of the bidirectional driving pump are respectively communicated with the flow path distribution module and the ion concentration testing module.
The biochemical analyzer provided by the embodiment of the application has the beneficial effects that: compared with the prior art, the biochemical analyzer of the embodiment of the application, through integrated a plurality of reaction detecting systems and ion detecting system in the organism, through the content of a plurality of components of a plurality of reaction detecting system detection analysis samples, through ion concentration in the ion detecting system detection sample to realize the detection and analysis of a plurality of components of sample, with reduce analyzer kind quantity, reduce cost, need not partial shipment sample, it is efficient, and can reduce the quantity of sample moreover.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the embodiments or exemplary technical descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a biochemical analyzer provided in an embodiment of the present application;
FIG. 2 is a schematic side view of a biochemical analyzer according to an embodiment of the present disclosure;
FIG. 3 is a schematic rear view of a biochemical analyzer according to an embodiment of the present application;
FIG. 4 is a schematic view of a flow path structure of a biochemical analyzer according to an embodiment of the present disclosure;
fig. 5 is a schematic view of a flow path structure of a sample adding system provided in an embodiment of the present application;
fig. 6 is a schematic view of a flow path structure of an ion detection system according to an embodiment of the present disclosure;
FIG. 7 is a schematic view of a flow path structure of a reaction detection system according to an embodiment of the present disclosure;
fig. 8 is a schematic view of a flow path structure of a dilution system according to an embodiment of the present application.
Wherein, in the drawings, the reference numerals are mainly as follows:
100-a biochemical analyzer;
11-body; 12-a sample holder; 13-a reagent tube; 14-an interface board; 141-base fluid interface; 141 a-first base fluid interface; 141 b-second base fluid interface; 142-a waste interface; 143-pure water interface; 144-standard liquid interface; 144 a-first standard fluid interface; 144 b-a second label fluid interface; 15-multi-way pipe;
20-a sample application system; 21-a sampling needle; 22-a drive mechanism; 221-swing arm; 222-a strut; 223-a scaffold; 224-a lift drive module; 225-a rotation drive module; 23-a plunger pump; 24-a flush pump; 25-a shut-off valve;
30-a cleaning system; 31-a cleaning cup; 311-a washing chamber; 32-a purge pump set; 321-a cleaning liquid supply pump; 322-cleaning fluid evacuation pump;
40-ion detection system; 41-sample adding cup; 411-sample application cavity; 42-ion concentration test module; 421-a detection electrode; 422-a first liquid detector; 423-second liquid detector; 43-a bi-directional drive pump; 44-a flow path distribution module; 441-a flow plate; 4411-a primary flow path; 4412-a branch flow path; 44121-air branch; 44122-a first standard sample branch; 44123-a second standard sample branch; 44124-rinsing branch; 442-a control valve; 45-a discharge pump; 46-a kit; 461-first standard reagent package; 462-a second standard reagent package; 463-flush reagent pack;
50-a reaction detection system; 51-a reactor; 51 a-a first reactor; 51 b-a second reactor; 511-a reaction chamber; 512-overflow pipe; 513-liquid injection pipe; 514-evacuation pipe; 52-a detector; 53-a first stirrer; 531-first stirring member; 532-a first magnetic attachment; 533-a first motor; 54-a reaction detection pump set; 541-double peristaltic pumps; 5411-first pump tube; 5412-a second pump tube; 542-single peristaltic pump; 5421-third pump tube;
60-a dilution system; 61-dilution cup; 611-a dilution chamber; 612-an overflow channel; 613-liquid injection channel; 614-evacuation channel; 62-a second stirrer; 621-a second stirring member; 622-a second magnetically attractive element; 623-a second motor; 63-a dilution pump group; 631-double peristaltic dilution pump; 6311-first dilution pump tube; 6312-second dilution pump tube; 632-single peristaltic dilution pump; 6321-third dilution pump tube;
70-standard liquid supply system; 71-standard liquid cup; 711-standard liquid chamber; 711 a-first label chamber; 711 b-second label chamber; 712-a recovery chamber; 72-standard liquid pump set; 721-standard liquid supply pump; 7211-a first standard liquid pump tube; 7212-a second marker liquid pump tube; 722-standard liquid emptying pump;
81-a source of base liquid; 81 a-a first source of substrate liquid; 81 b-a second source of substrate liquid; 82-a waste liquid collection container; 83-pure water source; 84-standard liquid source; 84 a-a first source of standard liquid; 84 b-second standard liquid source.
Detailed Description
In order to make the technical problems, technical solutions and advantageous effects to be solved by the present application clearer, the present application is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.
It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless specifically limited otherwise. The meaning of "a number" is one or more unless specifically limited otherwise.
In the description of the present application, it is to be understood that the terms "center", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present application and for simplicity in description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present application.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
Reference throughout this specification to "one embodiment," "some embodiments," or "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in one or more embodiments of the present application. Thus, appearances of the phrases "in one embodiment," "in some embodiments," "in other embodiments," or the like, in various places throughout this specification are not necessarily all referring to the same embodiment, but rather "one or more but not all embodiments" unless specifically stated otherwise. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
Referring to fig. 1, 2 and 4, a biochemical analyzer 100 provided herein will now be described. The biochemical analyzer 100 includes a body 11, a sample holder 12, a sample application system 20, a plurality of reaction detection systems 50, an ion detection system 40, and a cleaning system 30. Sample frame 12, application of sample system 20, a plurality of reaction detecting system 50, ion detecting system 40 and cleaning system 30 are installed on organism 11, support sample frame 12, application of sample system 20, a plurality of reaction detecting system 50, ion detecting system 40 and cleaning system 30 through organism 11 to convenient transportation and use.
The sample holder 12 is configured to store the reagent vessel 13, that is, the reagent vessel 13 may be mounted on the sample holder 12. For example, the sample may be placed in the reagent tube 13, and the reagent tube 13 may be placed in the sample holder 12, so that the sample is placed in the sample holder 12 for detection and analysis.
Each reaction detection system 50 includes a reactor 51 and a detector 52, the reactor 51 has a reaction chamber 511 formed therein, and the top of the reaction chamber 511 is open so that a liquid such as a sample is filled into the reaction chamber 511. The detector 52 is installed at the side of the reactor 51, and the detector 52 extends into the reaction chamber 511, so that the specific component in the liquid in the reaction chamber 511 can be directly detected, the biochemical analysis can be realized, and the efficiency is high. A plurality of reaction detection systems 50 are provided to detect the amount of various components in a sample. It is understood that a mounting hole may be provided at a side of the reactor 51, the mounting hole communicating with the reaction chamber 511, and the detector 52 is mounted in the mounting hole so as to mount the detector 52.
The sample application system 20 includes a sampling needle 21 and a driving mechanism 22, and the sampling needle 21 is mainly used to suck a sample and apply the sample to a predetermined position, such as the reaction chamber 511. The driving mechanism 22 is mounted on the machine body 11, the sampling needle 21 is mounted on the driving mechanism 22, and the driving mechanism 22 drives the sampling needle 21 to move so as to sample.
The ion detection system 40 is configured to detect the ion concentration in the sample, and the ion detection system 40 includes a sample cup 41 and an ion concentration testing module 42, and the sample cup 41 and the ion concentration testing module 42 are installed in the body 11. The sample adding cup 41 is used for adding a sample, the ion concentration testing module 42 is used for detecting the ion concentration in the sample, the sample adding cup 41 is communicated with the ion concentration testing module 42, so that the sample is added into the sample adding cup 41, and the sample can flow to the ion concentration testing module 42, so that the ion concentration testing module 42 can detect the ion concentration in the sample.
The cleaning system 30 is configured to clean the sampling needle 21, and the cleaning system 30 includes a cleaning cup 31, and the cleaning cup 31 is installed in the body 11. In use, the sampling needle 21 is inserted into the cleaning cup 31 to clean the sampling needle 21. Of course, the sampling needle 21 may suck the cleaning liquid into the sample cup 41 to clean the sample cup 41. The sampling needle 21 may also suck a cleaning solution into the reaction chamber 511 to clean the reaction chamber 511.
In use, the sampling needle 21 needs to be inserted into the cleaning cup 31 for cleaning every time sampling. The sampling needle 21 of the sample application system 20 applies a sample to the reaction chambers 511 of the plurality of reactors 51, and the content of the plurality of components in the sample is detected by the detectors 52 provided in the plurality of reactors 51. The sampling needle 21 takes a sample into the sample application cup 41 to detect the ion concentration in the sample by the ion concentration test module 42. Therefore, the detection of various components and ion concentrations in the sample can be realized, the efficiency is high, and the cost is low.
The biochemical analyzer 100 provided by the embodiment of the application, compared with the prior art, through integrating a plurality of reaction detecting systems 50 and ion detecting system 40 in organism 11, detect the content of the multiple components of the analysis sample through a plurality of reaction detecting systems 50, detect ion concentration in the sample through ion detecting system 40, thereby realize the detection and analysis of the multiple components of the sample, in order to reduce the analyzer kind quantity, reduce cost, need not the partial shipment sample, high efficiency, and can reduce the quantity of the sample.
In one embodiment, referring to fig. 1, 4 and 5, the driving mechanism 22 includes a bracket 223, a swing arm 221, a support rod 222, a lifting driving module 224 and a rotation driving module 225. The bracket 223 is installed in the machine body 11, and the bracket 223 mainly plays a role in installation and support. The sampling needle 21 is mounted on the swing arm 221, and the sampling needle 21 is supported by the swing arm 221. The swing arm 221 is mounted on the support rod 222, and the swing arm 221 is supported by the support rod 222, thereby supporting the sampling needle 21. The rod 222 is movably mounted on the bracket 223 so that the rod 222 can move up and down and rotate on the bracket 223. The lifting driving module 224 is installed on the bracket 223, and the lifting driving module 224 is connected to the supporting rod 222 to drive the supporting rod 222 to move up and down, so as to drive the swing arm 221 and the sampling needle 21 to move up and down. The rotation driving module 225 is installed on the bracket 223, and the rotation driving module 225 is connected to the rod 222 to drive the rod 222 to rotate, so as to drive the swing arm 221 and the sampling needle 21 to rotate. The sample rack 12, the plurality of reactors 51, the sample adding cup 41 and the cleaning cup 31 are disposed around the supporting rod 222, so that when the driving module 225 is rotated to drive the supporting rod 222 to rotate, and further drive the swing arm 221 and the sampling needle 21 to rotate, the sampling needle 21 can be inserted into each reagent tube 13 of the sample rack 12, the reaction chamber 511 of each reactor 51, the sample adding cup 41 and the cleaning cup 31. It will be appreciated that the drive mechanism 22 may also use a three-axis motion stage to drive the movement of the sampling needle 21.
In one embodiment, referring to fig. 1, 4 and 5, the rod 222 may be rotatably connected to the lifting driving module 224, and the rod 222 is supported on the lifting driving module 224, and the rod 222 is slidably connected to the rotating driving module 225. For example, the lifting driving module 224 may be connected to the supporting rod 222 through a rotating base, and the rotating driving module 225 is slidably connected to the supporting rod 222 through a sliding sleeve, so that the rotating driving module 225 drives the sliding sleeve to rotate to drive the supporting rod 222 to rotate, and the lifting driving module 224 drives the rotating base to lift to drive the supporting rod 222 to lift, so that the lifting driving module 224 drives the supporting rod 222 to lift, and the rotating driving module 225 can drive the supporting rod 222 to rotate. The elevation drive module 224 may use a linear motor, a synchronous belt drive assembly, a lead screw and nut mechanism, a rack and pinion mechanism, etc. The rotary drive module 225 may use a belt drive assembly, a gear drive assembly, or the like.
It is understood that the rod 222 may also be mounted on the rotation driving module 225, and the rotation driving module 225 supports and drives the rod 222 to rotate. The rotation driving module 225 is installed on the lifting driving module 224, and the lifting driving module 224 drives the rotation driving module 225 to lift, so as to drive the supporting rod 222 to move up and down. Of course, the lifting driving module 224 can also be used to support and drive the supporting rod 222 to lift, and the rotation driving module 225 drives the lifting driving module 224 to rotate, so as to drive the supporting rod 222 to rotate.
In one embodiment, referring to fig. 1, 4 and 5, the sample application system 20 includes a plunger pump 23 and a flush pump 24. The flush pump 24 has an inlet and an outlet, and when the flush pump 24 is in operation, fluid enters the flush pump 24 from the inlet of the flush pump 24, is pressurized, and then exits the outlet of the flush pump 24.
The plunger pump 23 has a cylinder (not shown) in which a plunger is movably installed and a plunger (not shown) which moves in the cylinder to vary a volume of the cylinder enclosed with the plunger to achieve pumping of the liquid and to precisely control an amount of the pumped liquid. For example, when the plunger moves away from the outlet of the plunger pump 23, the volume of the enclosed portion of the cylinder with the plunger increases to suck the liquid, and when the plunger moves close to the outlet of the plunger pump 23, the volume of the enclosed portion of the cylinder with the plunger decreases to pump the liquid, so as to realize the precise control of the liquid pumping amount.
The inlet of the flush pump 24 is adapted to be connected to a source of cleaning fluid so that the flush pump 24 can pump cleaning fluid when in operation. The outlet of the flushing pump 24 is communicated with the inlet of the plunger pump 23, and the outlet of the plunger pump 23 is communicated with the sampling needle 21, so that when the flushing pump 24 works, cleaning liquid is pressurized by the flushing pump 24, enters the plunger pump 23 from the inlet of the plunger pump 23, and then enters the sampling needle 21 from the outlet of the plunger pump 23, so as to flush the inside of the sampling needle 21. After the flushing is completed, the flushing pump 24 stops working, and the plunger pump 23 works to control the sampling needle 21 to sample and sample.
In one embodiment, referring to fig. 1, fig. 4 and fig. 5, the sample adding system 20 further includes a shut-off valve 25, the shut-off valve 25 is located between the flushing pump 24 and the plunger pump 23, one end of the shut-off valve 25 is connected to the inlet of the plunger pump 23, the other end of the shut-off valve 25 is connected to the outlet of the flushing pump 24, the inlet of the plunger pump 23 is controlled to be opened or closed by the shut-off valve 25, so that when the flushing pump 24 stops working, the shut-off valve 25 is closed, and when the plunger pump 23 works, only liquid can be sucked in and discharged from the sampling needle 21, so as to precisely control the sampling and sample adding of the sampling needle 21. It will be appreciated that a valve may also be integrated within the plunger pump 23 so that only liquid can be drawn in and out of the sampling needle 21 when the plunger pump 23 is in operation. It is understood that when the pump body such as a diaphragm pump or a peristaltic pump is used as the flushing pump 24, and when the flushing pump 24 is stopped, the outlet of the flushing pump 24 can be ensured to be closed, the closing valve 25 may not be provided, and when the plunger pump 23 is operated, it can be ensured that only the liquid is sucked and discharged from the sampling needle 21.
In one embodiment, the shut-off valve 25 is an electromagnetic valve to realize automatic control of the on-off of the inlet of the plunger pump 23, so that the control is quick and convenient, and the efficiency is improved. It is understood that the shut-off valve 25 may be an electric valve or a pneumatic valve, and that the opening and closing of the inlet of the plunger pump 23 can be automatically controlled. Of course, other valve configurations for the shut-off valve 25 may be used.
In one embodiment, when the shut-off valve 25 is provided, or when the flushing pump 24 is stopped, it is ensured that the outlet of the flushing pump 24 is shut off, the inlet of the plunger pump 23 and the outlet of the plunger pump 23 can be always communicated, which facilitates the processing and manufacturing of the plunger pump 23.
In one embodiment, an outlet and an inlet may be respectively disposed at two ends of a cylinder of the plunger pump 23, the inlet of the plunger pump 23 is communicated with the inlet of the cylinder, and the outlet of the plunger pump 23 is communicated with the outlet of the cylinder, so that when the plunger is located between the outlet of the cylinder and the inlet of the cylinder, the inlet of the plunger pump 23 can be closed by the plunger, and when the plunger is located at an end of the cylinder away from the outlet, the inlet of the cylinder can be communicated with the outlet of the cylinder, and further the inlet of the plunger pump 23 is communicated with the outlet of the plunger pump 23, so that when flushing, the plunger is moved to an end away from the outlet of the cylinder first, and the flushing pump 24 is operated to flush the sampling needle 21; after the flushing is completed, the plunger moves towards the outlet of the cylinder body, the inlet of the plunger pump 23 is closed, then the plunger moves in the cylinder body, and the plunger is enabled to always separate the inlet and the outlet of the cylinder body, so that liquid can be sucked and discharged only from the sampling needle 21. Then, the shut-off valve 25 may not be provided in this structure, and accordingly, the impeller pump may be used as the flush pump 24.
In one embodiment, the flush pump 24 is a diaphragm pump to prevent other parts of the pump body from contacting the cleaning fluid to better flush the sampling needle 21. It will be appreciated that peristaltic pumps may also be used for the flush pump 24.
In one embodiment, when the shut-off valve 25 is provided, the outlet of the flush pump 24 is connected to the shut-off valve 25 via a conduit for ease of connection. It will be appreciated that the outlet of the flush pump 24 may also be connected directly to the shut-off valve 25. It will be appreciated that when the shut-off valve 25 is not provided, the outlet of the flush pump 24 may be connected to the inlet of the plunger pump 23 by a conduit, which is convenient. Of course, the outlet of the flush pump 24 may be directly connected to the inlet of the plunger pump 23 without providing the shut-off valve 25.
In the above embodiment, the connection among the sampling needle 21, the plunger pump 23 and the flushing pump 24 can be realized by using pipe fittings, so that the connection is convenient, the position arrangement of the plunger pump 23 and the flushing pump 24 is convenient, and the connection of the cleaning liquid source is also convenient. In addition, pure water can be used as the cleaning liquid, and the cost is low.
In one embodiment, referring to fig. 1, 4 and 6, the ion detection system 40 further includes a discharge pump 45, a bidirectional driving pump 43 and a flow path distribution module 44, wherein two ends of the bidirectional driving pump 43 are respectively communicated with the flow path distribution module 44 and the ion concentration testing module 42. The flow path distribution module 44 is used for controlling various media sources to be respectively communicated with the bidirectional driving pump 43, for example, when the bidirectional driving pump is used, the flow path distribution module 44 can be connected with media such as flushing liquid, pure water, various standards, buffer liquid, curing liquid, air and the like, the flow path distribution module 44 is communicated with the bidirectional driving pump 43, the bidirectional driving pump 43 is communicated with the ion concentration testing module 42, when the bidirectional driving pump 43 rotates forwards, the flushing liquid can be pumped through the control of the flow path distribution module 44, the flushing liquid passes through the flow path distribution module 44, is pressurized to the bidirectional driving pump 43, then flows to the ion concentration testing module 42 to clean the ion concentration testing module 42, and then flows to the sample adding cup 41 to clean the sample adding cup 41. Of course, the cleaning may be performed using pure water. Similarly, when the bidirectional driving pump 43 is driven to rotate forward, the flow path distribution module 44 can be controlled to pump the reagent such as pure water or standard sample to the ion concentration measuring module 42, or even to the sample cup 41. Because the volume of the whole flow path is large, when the bidirectional driving pump 43 rotates forwards, particularly when reagents such as flushing liquid, various standards and the like are extracted, only the amount of the reagents which can be filled in the ion concentration testing module 42 can be extracted, and then the air source (such as the outside) is switched to be communicated with the bidirectional driving pump 43 through the flow path distribution module 44, so that the use of the reagents can be reduced. The drain pump 45 is used to drain the liquid in the loading cup 41 to a designated position, such as the waste liquid collection container 82.
It is understood that the flow path distribution block 44 may be connected to the waste liquid collection container 82 through a pipe, so that the liquid in the flow path from the sample cup 41 to the flow path distribution block 44 can be discharged to the waste liquid collection container 82 through the control of the flow path distribution block 44 by driving the pump 43 in both directions, thereby eliminating the need for the discharge pump 45.
In one embodiment, tubing may be used for communication between the sample cup 41, the ion concentration testing module 42, the drain pump 45, the bi-directional drive pump 43, and the flow path distribution module 44 to facilitate the placement of the sample cup 41, the ion concentration testing module 42, the drain pump 45, the bi-directional drive pump 43, and the flow path distribution module 44.
In one embodiment, referring to fig. 1, 4 and 6, the ion concentration testing module 42 includes a detection electrode 421, a first liquid detector 422 and a second liquid detector 423. The detection electrode 421 of the ion concentration testing module 42 is used to detect the concentration of ions in a liquid such as a sample and a reagent. The detection electrode 421 of the ion concentration testing module 42 is used to detect the concentration of ions in a liquid such as a sample and a reagent. When a liquid such as a sample, a reagent, or the like enters the detection electrode 421, it can be detected by the detection electrode 421 to determine the ion concentration of the liquid in the detection electrode 421. The first liquid detector 422 is used to detect whether a liquid such as a sample or a reagent is present. When a liquid such as a sample or a reagent enters the first liquid detector 422, it can be detected by the first liquid detector 422. The second liquid detector 423 detects whether a liquid such as a sample or a reagent is present. When a liquid such as a sample, a reagent, etc. enters the second liquid detector 423, it can be detected by the second liquid detector 423. The first liquid detector 422 and the second liquid detector 423 are connected to opposite ends of the detection electrode 421, respectively; thus, when a liquid such as a reagent or a sample flows through the detection electrode 421 and both the first liquid detector 422 and the second liquid detector 423 detect the liquid, it can be determined that the liquid has filled the detection electrode 421, so that the usage amount of the sample and the reagent can be reduced, thereby reducing the detection cost and reducing the waste. The loading cup 41 communicates with an end of the first liquid detector 422 remote from the detection electrode 421, so that after the sample is loaded into the loading cup 41, the sample can flow into the first liquid detector 422, the detection electrode 421 and the second liquid detector 423.
In one embodiment, the detecting electrode 421 is plural, the plural detecting electrodes 421 are connected in sequence, and the plural detecting electrodes 421 are located between the first liquid detector 422 and the second liquid detector 423. By using the plurality of detection electrodes 421, the concentration of various ions in the sample can be detected, and the detection efficiency can be improved.
In one embodiment, the plurality of detection electrodes 421 includes at least one reference electrode and a plurality of ion electrodes for more accurate detection.
In one embodiment, the plurality of ion electrodes may be the same electrode to improve the detection accuracy of one ion concentration. Of course, the ion electrodes may be different electrodes to detect different ion concentrations, so as to improve the detection efficiency.
In one embodiment, the ion electrode may be one or more of a pH electrode, a Na electrode, a K electrode, a Cl electrode, a Ca electrode, and the like.
In one embodiment, the first liquid detector 422 may be a light-sensitive sensor to detect whether liquid flows through the first liquid detector 422 by sensing light. It is understood that other sensors, such as ultrasonic sensors, etc., may be used for the first liquid detector 422.
In one embodiment, the second liquid detector 423 may be a light-sensitive sensor to detect whether liquid flows through the second liquid detector 423 by sensing light. It is understood that other sensors, such as ultrasonic sensors, may be used with the second liquid detector 423.
In one embodiment, the sample adding cup 41 is provided with a sample adding cavity 411, and the bottom of the sample adding cavity 411 is communicated with the ion concentration testing module 42, so that a sample in the sample adding cavity 411 enters the ion concentration testing module 42. Of course, when the ion detection system 40 includes the drain pump 45, the bottom of the sample addition chamber 411 is in communication with the drain pump 45 to drain the sample addition chamber 411.
In one embodiment, the discharge pump 45 may be a peristaltic pump to facilitate quantitative control and avoid the discharge liquid from affecting other components of the pump. It is to be understood that the drain pump 45 may also use a pump member such as the plunger pump 23, the diaphragm pump, or the like.
In one embodiment, the bi-directional drive pump 43 is a peristaltic pump to facilitate quantitative control, avoid discharged fluid from affecting other components of the pump, and simplify construction. It is to be understood that the bidirectional driving pump 43 may also use a pump member such as a piston pump having electromagnetic valves at both ends thereof, which can realize bidirectional quantitative control.
In one embodiment, referring to fig. 1, 4 and 6, the flow path distribution module 44 includes a flow path plate 441 and a plurality of control valves 442, the flow path plate 441 has a main flow path 4411 and a plurality of branch flow paths 4412 respectively connected to each media source, the control valves 442 are in one-to-one correspondence with the branch flow paths 4412, each control valve 442 is mounted on the flow path plate 441, each control valve 442 is connected to the corresponding branch flow path 4412 and the main flow path 4411, each control valve 442 is used for controlling the corresponding branch flow path 4412 to communicate with the main flow path 4411, and the main flow path 4411 communicates with the bidirectional driving pump 43. The plurality of branch flow paths 4412 may be respectively connected to different media sources, such as a rinse solution source, a pure water source, a standard sample source, a buffer solution source, a maintenance solution source, and an air source, and the control valves 442 control the different media sources to communicate with the main flow path 4411, so as to draw different media to the detection electrode 421 or the sample cup 41 when the bidirectional driving pump 43 operates. It is understood that the flow path distribution module 44 may also use a multi-way valve.
Of course, it is also possible to connect a branch flow path 4412 to the waste liquid collecting container 82, that is, one branch flow path 4412 is a waste liquid discharge branch, so that the liquid from the sample cup 41 to the main flow path 4411 can be discharged to a waste liquid bottle by the operation of the bidirectional driving pump 43, and thus the above-mentioned discharge pump 45 is not required, so as to simplify the structure and reduce the cost.
In one embodiment, referring to fig. 1, 4 and 6, the plurality of branch flow paths 4412 include an air branch 44121, a first standard sample branch 44122, a second standard sample branch 44123 and a rinse branch 44124, the air branch 44121 is configured to be connected to outside air to provide a connection to an air source. The first sample branch 44122 is used to connect the first sample, i.e., the first sample branch 44122 is connected to a first sample source. The second sample branch 44123 is used for connecting a second sample, that is, the second sample branch 44123 is connected to a second sample source. The rinse branch 44124 is used to connect rinse solution, i.e., the rinse branch 44124 is connected to a source of rinse solution. In this way, the detection electrode 421 can be calibrated by the first standard sample and the second standard sample to ensure the accuracy of detection. In addition, the washing branch 44124 is provided, so that when the ion detection system 40 is used for a long time or is not used for a long time, the detection electrode 421 can be washed by using a washing liquid, so as to ensure the detection accuracy.
In one embodiment, the flow path distribution module 44 includes four branch flow paths 4412. It is to be understood that the number of the branch flow paths 4412 may be three, five, six, or the like, and may be specifically set as needed. The plurality of branch flow paths 4412 may further include a pure water branch line to connect a pure water source, for example.
In one embodiment, the control valve 442 may be a solenoid valve to facilitate automatic control. It is to be understood that the control valve 442 may also be an electrically operated valve, a pneumatically operated valve, or the like.
In one embodiment, referring to fig. 1, fig. 4 and fig. 6, the ion detection system 40 further includes a reagent kit 46, the reagent kit 46 is provided with a first standard reagent packet 461, a second standard reagent packet 462 and a washing reagent packet 463, and the first standard reagent packet 461, the second standard reagent packet 462 and the washing reagent packet 463 are respectively communicated with the flow path distribution module 44. Such as a first standard reagent pack 461, in communication with the first standard branch 44122. The second standard reagent pack 462 is in communication with the second standard branch 44123. The rinse reagent pack 463 is in communication with the rinse branch 44124 for connected use. The first standard reagent pack 461 stores a first standard such that the first standard reagent pack 461 forms a first standard source such that the detection electrode 421 can be calibrated using the first standard. Of course, the first standard sample may be used to clean the channel between the detection electrode 421 and the flow channel distribution block 44. The second standard reagent pack 462 stores a second standard such that the second standard reagent pack 462 forms a second standard source such that the first and second standards can be used to calibrate the sensing electrode 421 to ensure accuracy of the sensing. The rinse reagent pack 463 stores a rinse liquid so that the rinse reagent pack 463 forms a source of the rinse liquid, and thus when the ion detection system 40 is used for a long time or is not used for a long time, the rinse liquid can be used to rinse the detection electrode 421 to ensure the accuracy of detection. The kit 46 is used to facilitate installation. It will be appreciated that the flow distribution modules 44 may also be connected directly to the respective media sources.
In one embodiment, referring to fig. 1, 4 and 7, each reaction detecting system 50 further includes a reaction detecting pump unit 54, and the reaction detecting pump unit 54 is used for pumping a substrate solution into the reaction chamber 511 to be mixed with the sample in the reaction chamber 511, or cleaning the reaction chamber 511 with the substrate solution, and after cleaning, the substrate solution can be filled into the reaction chamber 511 to react with the sample to facilitate detection of the sample. The reaction detection pump unit 54 is also used to evacuate the reaction chamber 511 of liquid so that the reaction chamber 511 of liquid can be evacuated. It is understood that the sampling needle 21 may be used to fill the reaction chamber 511 with the substrate solution or to draw the reaction chamber 511.
In one embodiment, referring to fig. 1, 4 and 7, the overflow pipe 512, the liquid injection pipe 513 and the emptying pipe 514 are disposed on the reactor 51, and the overflow pipe 512, the liquid injection pipe 513 and the emptying pipe 514 are all communicated with the reaction chamber 511. The liquid injection pipe 513 is used for injecting liquid into the reaction chamber 511, for example, injecting a base liquid into the reaction chamber 511 to clean the reaction chamber 511 by the base liquid, and in addition, the base liquid can be injected into the reaction chamber 511 after cleaning so as to react with the sample and facilitate detection of the sample. The overflow pipe 512 is used to drain the excess liquid in the reaction chamber 511, so that the excess liquid in the reaction chamber 511 can be quantified through the overflow pipe 512, for example, when the excess substrate liquid is filled into the reaction chamber 511, the excess substrate liquid will be drained through the overflow pipe 512, so as to ensure the quantification of the substrate liquid in the reaction chamber 511. The evacuation tube 514 is used to evacuate the reaction chamber 511, such as to evacuate the reaction chamber 511 through the evacuation tube 514 after the reaction chamber 511 is cleaned, and to evacuate the reaction chamber 511 through the evacuation tube 514 after the detection. By arranging the liquid injection pipe 513 to inject the base liquid, a sampling gun is not needed, and the efficiency is high. The overflow pipe 512 is used to quantify the liquid in the reaction chamber 511, so that the efficiency can be further improved.
In one embodiment, the set of reaction detection pumps 54 includes a dual peristaltic pump 541 and a single peristaltic pump 542. The double peristaltic pump 541 is a peristaltic pump having two pump tubes. The single peristaltic pump 542 refers to a peristaltic pump having one pump tube. The dual peristaltic pump 541 has a first pump tube 5411 and a second pump tube 5412. One end of the first pump conduit 5411 is communicated with the liquid injection conduit 513, and the other end of the first pump conduit 5411 is used for connecting the substrate liquid source 81. One end of the second pump tube 5412 is communicated with the overflow tube 512, and the other end of the second pump tube 5412 is used for connecting the waste liquid collection container 82. Thus, when the double peristaltic pump 541 is operated, the first pump tube 5411 pumps the substrate liquid to fill the reaction chamber 511, and the second pump tube 5412 generates a negative pressure at the overflow tube 512 to timely pump out the liquid overflowing from the reaction chamber 511. The single peristaltic pump 542 has a third pump tube 5421, one end of the third pump tube 5421 is in communication with the evacuation tube 514, and the other end of the third pump tube 5421 is for connecting to the waste collection container 82. So that the reaction chamber 511 can be better evacuated when the single peristaltic pump 542 is operated. Use two peristaltic pumps 541 and single peristaltic pump 542, simple structure, it is efficient, in addition, can conveniently control, use two peristaltic pumps 541 to also promote the integrated level, reduce the volume. It will be appreciated that other pumping elements may be used, such as a vane pump, centrifugal pump, plunger pump 23, etc. In addition, three pumping elements may be provided, one pumping element has two ends connected to the substrate liquid source 81 and the liquid injection pipe 513, one pumping element has two ends connected to the waste liquid collecting container 82 and the overflow pipe 512, and the third pumping element has two ends connected to the waste liquid collecting container 82 and the emptying pipe 514, respectively, so as to realize automatic substrate liquid filling, overflow liquid draining and reaction chamber 511 emptying in the reaction chamber 511.
In one embodiment, the detector 52 may use an electrode biosensor. The electrode type biosensor is based on a mildew membrane method, a sample to be detected (hereinafter referred to as a sample to be detected) reacts with a mildew membrane to generate an electric signal, and the concentration of a detected item is analyzed through the recognition of the electric signal by the electrode of the electrode type biosensor. The electrode life and accuracy based on the mildew film method can be attenuated to different degrees due to the increase of the number of samples, the concentration of the samples, the working time and other factors. Wherein the sample concentration directly affects the accuracy and the service life of the electrode. Without being limited thereto, the electrode type biosensor cannot directly measure the sample stock solution. At this time, the substrate solution may be a buffer solution, and the reaction chamber 511 is filled with the buffer solution until the excess overflows. And then the sample to be measured (namely the sample to be measured) is added into the reaction cavity 511 and is uniformly stirred by the stirrer, and the sample is diluted by a certain multiple, so that the accuracy and the service life of the electrode type biosensor are guaranteed to a certain extent. It will be appreciated that other biosensors may be used for the detector 52, such as light sensitive sensors, etc.
In one embodiment, referring to fig. 1, 4 and 7, two detectors 52 can be installed on the reactor 51, and the two detectors 52 can be the same to detect the same component at the same time, so as to ensure the accuracy of the detection. Of course, the two detectors 52 may also be different to detect different components. It will be appreciated that only one detector 52 may be mounted on the reactor 51. Of course, three, four, etc. detectors 52 may be provided on the reactor 51. The detectors 52 on the multiple reactors 51 are of different types to detect different components of the sample. Since the types of the detectors 52 on the plurality of reactors 51 are different, the base solutions added into the corresponding reaction chambers 511 are also different, for example, in this embodiment, two reactors 51 are provided, which are a first reactor 51a and a second reactor 51b, respectively, and two corresponding base solution sources 81 are provided, which are a first base solution source 81a and a second base solution source 81b, respectively. The first substrate liquid source 81a raises the first substrate liquid toward the first reactor 51 a; the second substrate liquid source 81b raises the second substrate liquid toward the second reactor 51 a.
In one embodiment, the reactor 51 further includes a first stirrer 53, the first stirrer 53 includes a first magnetic attraction member 532, a first stirring member 531 and a first motor 533, the first magnetic attraction member 532 is disposed at the bottom of the reactor 51, the first magnetic attraction member 532 is spaced apart from the reaction chamber 511, and the first motor 533 is connected to the first magnetic attraction member 532, so as to drive the first magnetic attraction member 532 to rotate through the first motor 533. First stirring piece 531 is arranged in reaction chamber 511, and first stirring piece 531 is connected with first magnetism piece 532 in an adsorption manner, that is to say, first magnetism piece 532 adsorbs first stirring piece 531 in a magnetic adsorption manner, so that when first magnetism piece 532 rotates, first stirring piece 531 can be driven to rotate in reaction chamber 511, and liquid in reaction chamber 511 is stirred, which is convenient for liquid in reaction chamber 511 to mix rapidly.
In one embodiment, referring to fig. 1, 4 and 8, the biochemical analyzer 100 further comprises a dilution system 60, the dilution system 60 being used to dilute the sample. The dilution system 60 includes a dilution cup 61 and a dilution pump group 63, the dilution cup 61 being mounted in the machine body 11. A dilution pump unit 63 for supplying a dilution liquid into the dilution cup 61 to dilute the sample; in addition, the dilution pump unit 63 is also used to evacuate the dilution cup 61. It will be appreciated that the sampling needle 21 may also be used to fill the dilution cup 61 with dilution liquid or to withdraw the dilution cup 61. Some samples have large concentration, and the dilution directly in the reaction chamber 511 is often difficult to reach the optimal detection concentration of the detector 52, so that the sample needs to be diluted again. The dilution system 60 is arranged, so that the detection sample can reach the optimal concentration for detection, and the detection is more accurate.
In one embodiment, pure water may be used as the diluent. It will be appreciated that other diluting agents may be used.
In an embodiment, referring to fig. 1, fig. 4 and fig. 8, a dilution chamber 611 is disposed in the dilution cup 61, an overflow channel 612, a filling channel 613 and an emptying channel 614 are disposed on the dilution cup 61, and the overflow channel 612, the filling channel 613 and the emptying channel 614 are all communicated with the dilution chamber 611. The liquid injection channel 613 is used to inject a diluting liquid into the dilution chamber 611 to wash the dilution chamber 611 with the diluting liquid, and in addition, the diluting liquid may be injected into the dilution chamber 611 after the washing so as to mix the diluted sample with the sample. The overflow passage 612 is used for discharging the excess liquid in the dilution chamber 611, so that the liquid in the dilution chamber 611 can be quantified through the overflow passage 612, for example, when the excess dilution liquid is filled into the dilution chamber 611, the excess dilution liquid is discharged through the overflow passage 612, so as to ensure the quantification of the dilution liquid in the dilution chamber 611. The drain channel 614 is used for draining the liquid in the dilution chamber 611, such as after the dilution chamber 611 is cleaned, draining the liquid in the dilution chamber 611 through the drain channel 614, and after the detection is finished, draining the liquid in the dilution chamber 611 through the drain channel 614. By arranging the liquid injection channel 613, diluent is injected, a sampling gun is not needed, and the efficiency is high. The use of the overflow channel 612 to quantify the amount of liquid in the dilution chamber 611 further improves efficiency.
In one embodiment, dilution pump set 63 includes dual peristaltic dilution pumps 631 and a single peristaltic dilution pump 632. The dual peristaltic dilution pump 631 is a peristaltic pump having two pump tubes. The single peristaltic dilution pump 632 refers to a peristaltic pump having one pump tube. The dual peristaltic dilution pump 631 has a first dilution pump tube 6311 and a second dilution pump tube 6312. One end of the first dilution pump pipe 6311 is communicated with the liquid injection passage 613, and the other end of the first dilution pump pipe 6311 is used for connecting a diluent source. One end of the second dilution pump pipe 6312 is communicated with the overflow passage 612, and the other end of the second dilution pump pipe 6312 is used to connect the waste liquid collection container 82. Thus, when the double peristaltic dilution pump 631 is operated, the first dilution pump tube 6311 pumps the diluent to fill the dilution chamber 611, and the second dilution pump tube 6312 generates a negative pressure at the overflow passage 612 to timely pump out the liquid overflowing from the dilution chamber 611. The single peristaltic dilution pump 632 has a third dilution pump tube 6321, one end of the third dilution pump tube 6321 is connected to the evacuation channel 614, and the other end of the third dilution pump tube 6321 is used to connect to the waste liquid collection container 82. So that the dilution chamber 611 can be better evacuated when the single peristaltic dilution pump 632 is operating. Use two peristaltic dilution pumps 631 and single peristaltic dilution pump 632, simple structure, it is efficient, in addition, can conveniently control, use two peristaltic dilution pumps 631 and also can promote the integrated level, reduce the volume. It will be appreciated that other pumping elements may be used, such as a vane pump, centrifugal pump, plunger pump 23, etc. In addition, three pumping elements may be provided, one pumping element has two ends connected to the diluent source and the liquid injection channel 613, one pumping element has two ends connected to the waste liquid collecting container 82 and the overflow channel 612, and the third pumping element has two ends connected to the waste liquid collecting container 82 and the emptying channel 614, respectively, so as to automatically fill the diluent into the dilution cavity 611, discharge the overflow liquid and empty the dilution cavity 611.
In one embodiment, the dilution cup 61 further includes a second stirrer 62, the second stirrer 62 includes a second magnetic attraction member 622, a second stirring member 621, and a second motor 623, the second magnetic attraction member 622 is disposed at the bottom of the dilution cup 61, the second magnetic attraction member 622 is spaced apart from the dilution cavity 611, and the second motor 623 is connected to the second magnetic attraction member 622 to drive the second magnetic attraction member 622 to rotate via the second motor 623. The second stirring part 621 is disposed in the dilution cavity 611, and the second stirring part 621 and the second magnetic attraction part 622 are connected, that is, the second magnetic attraction part 622 magnetically attracts the second stirring part 621, so that when the second magnetic attraction part 622 rotates, the second stirring part 621 can be driven to rotate in the dilution cavity 611 to stir the liquid in the dilution cavity 611, thereby facilitating the rapid mixing of the liquid in the dilution cavity 611.
In one embodiment, referring to fig. 1 and 4, the biochemical analyzer 100 further includes a standard solution supply system 70, the standard solution supply system 70 configured to supply a standard solution for calibrating each detector 52 so that each detector 52 detects accurately. The standard liquid supply system 70 includes a standard liquid cup 71, and the standard liquid cup 71 is installed in the body 11 so that, in use, the standard liquid can be filled into the standard liquid cup 71 for use.
In one embodiment, referring to fig. 1 and 4, a plurality of sample solution cavities 711 and recycling cavities 712 are formed in the sample solution cup 71, and the recycling cavities 712 are communicated with the sample solution cavities 711 to collect liquid overflowing from the sample solution cavities 711. The standard solution chambers 711 correspond to the reactors 51 one by one. The standard liquid supply system 70 further comprises a standard liquid pump unit 72, and the standard liquid pump unit 72 is used for pumping the standard liquid into each standard liquid cavity 711 and for emptying the recovery cavity 712, so as to realize automatic supply of the standard liquid and automatic emptying of the recovery cavity 712.
In one embodiment, the target liquid pump set 72 includes a target liquid supply pump 721 and a target liquid evacuation pump 722, one end of the target liquid evacuation pump 722 is connected to the recovery chamber 712, and the other end of the target liquid evacuation pump 722 is connected to the waste liquid collection container 82 to evacuate the recovery chamber 712. The standard solution supply pumps 721 are in one-to-one correspondence with the standard solution chambers 711. One end of the standard liquid supply pump 721 is communicated with the corresponding standard liquid chamber 711, the other end of the standard liquid supply pump 721 is used for connecting standard liquid sources, the types of the standard liquid sources are in one-to-one correspondence with the standard liquid chambers 711, that is, different reactors 51 provide different standard liquid sources to supply standard liquid into the corresponding standard liquid chambers 711.
In one embodiment, the target liquid emptying pump 722 is a peristaltic pump, and has the advantages of simple structure, high efficiency and convenience in control. It will be appreciated that other pumping elements may be used with the subject liquid evacuation pump 722, such as a vane pump, centrifugal pump, plunger pump 23, etc. Similarly, the standard liquid supply pump 721 may use a peristaltic pump, a vane pump, a centrifugal pump, a plunger pump 23, or the like.
In one embodiment, there are two reaction detection systems 50 and two corresponding label chambers 711. It is understood that the reaction detection system 50 can be three, four, etc. in number, and the corresponding standard solution chamber 711 can be three, four, etc. Taking two reaction detecting systems 50 as an example, the number of the corresponding standard liquid cavities 711 is two, and the corresponding standard liquid cavities 711 are respectively a first standard liquid cavity 711a and a second standard liquid cavity 711b, and the number of the standard liquid sources 84 is two, and the corresponding standard liquid sources are respectively a first standard liquid source 84a and a second standard liquid source 84 b.
The standard liquid supply pump 721 is one, the standard liquid supply pump 721 is a double peristaltic standard liquid pump, and the double peristaltic standard liquid pump is a peristaltic pump having two pump tubes. The dual peristaltic standard pump has a first standard pump tube 7211 and a second standard pump tube 7212. One end of the first standard liquid pump tube 7211 communicates with the first standard liquid chamber 711a, and the other end of the first standard liquid pump tube 7211 is adapted to be connected to the first standard liquid source 84 a. One end of the second standard solution pump tube 7212 is connected to the second standard solution chamber 711b, and the other end of the second standard solution pump tube 7212 is connected to the second standard solution source 84 b. Thus, when the double peristaltic standard liquid pump works, the first standard liquid pump pipe 7211 pumps the first standard liquid to be filled into the first standard liquid cavity 711a, so that the automatic supply of the first standard liquid is realized; the second standard liquid pump pipe 7212 pumps the second standard liquid to be filled into the second standard liquid chamber 711b, thereby automatically supplying the second standard liquid. The double peristaltic liquid marking pump is used, the structure is simple, the efficiency is high, the control is convenient, the integration level is improved, and the size is reduced.
In one embodiment, the cleaning cup 31 is provided with a cleaning cavity 311, the cleaning system 30 further comprises a cleaning pump set 32, the cleaning pump set 32 is used for pumping cleaning liquid into the cleaning cavity 311, and the cleaning pump set 32 is also used for emptying the cleaning cavity 311 to supply cleaning liquid into the cleaning cavity 311 and empty the cleaning cavity 311.
In one embodiment, the cleaning pump group 32 includes a cleaning liquid supply pump 321 and a cleaning liquid evacuation pump 322, one end of the cleaning liquid supply pump 321 is communicated with the cleaning chamber 311, and the other end of the cleaning liquid supply pump 321 is used for connecting a cleaning liquid source to supply the cleaning liquid into the cleaning chamber 311. One end of the cleaning liquid emptying pump 322 is communicated with the cleaning cavity 311, and the other end of the cleaning liquid emptying pump 322 is used for connecting the waste liquid collecting container 82 so as to empty the liquid in the cleaning cavity 311.
In one embodiment, the cleaning solution supply pump 321 is a peristaltic pump, which is simple in structure, high in efficiency and convenient to control. It is understood that other pumping means such as a vane pump, a centrifugal pump, a plunger pump 23, etc. may be used as the cleaning liquid supply pump 321. Similarly, the cleaning liquid drain pump 322 may use a peristaltic pump, a vane pump, a centrifugal pump, the plunger pump 23, or the like.
In an embodiment, referring to fig. 4, a multi-way pipe 15 may be disposed in the body 11, and the pump units that need to be discharged to the waste liquid collecting container 82 are all connected to the multi-way pipe 15, such as the discharge pump 45, the second pump pipe 5412, the third pump pipe 5421, the second dilution pump pipe 6312, the third dilution pump pipe 6321, the standard liquid emptying pump 722, and the cleaning liquid emptying pump 322 are all connected to the multi-way pipe 15, and then connected to the waste liquid collecting container 82 through the multi-way pipe 15, so as to achieve the centralized recycling of waste liquid.
In one embodiment, referring to fig. 2 and 4, the discharge pump 45, the dual peristaltic pumps 541, the single peristaltic pumps 542, the dual peristaltic dilution pump 631, the single peristaltic dilution pump 632, the standard solution supply pump 721, the standard solution evacuation pump 722, and the cleaning solution evacuation pump 322 are installed on the same side of the machine body 11 to facilitate the connection of the pipelines and the layout.
In one embodiment, referring to fig. 3 and 4, the interface board 14 is installed on the body 11, a plurality of interfaces can be installed on the interface board 14 to connect each media source, and each system of the biochemical analyzer 100 can be connected to the corresponding interface to facilitate the connection and use of the pipeline.
In one embodiment, referring to fig. 3 and 4, the interface board 14 can be provided with a plurality of standard solution ports 144, the standard solution ports 144 correspond to the standard solution chambers 711 one by one, and the inlet of each standard solution supply pump 721 is connected to the corresponding standard solution port 144. In this embodiment, the number of the standard solution chambers 711 is two, the standard solution supply pump 721 is a double peristaltic standard solution pump, the number of the standard solution interfaces 144 is two, and the standard solution interfaces are respectively a first standard solution interface 144a and a second standard solution interface 144b, the first standard solution pump pipe 7211 is connected to the first standard solution interface 144a, and the second standard solution pump pipe 7212 is connected to the second standard solution interface 144b, so that when the device is used, the first standard solution source 84a can be connected to the first standard solution interface 144a, and the second standard solution source 84b can be connected to the second standard solution interface 144b, so that the device is convenient to connect and use.
In one embodiment, referring to fig. 3 and 4, the interface board 14 may be provided with a waste liquid interface 142, the multi-way tube 15 may be connected to the waste liquid interface 142, and the waste liquid interface 142 is connected to the waste liquid collecting container 82 to realize the centralized recycling of waste liquid.
In one embodiment, referring to fig. 3 and 4, the cleaning solution and the dilution solution can use pure water, the interface board 14 can be provided with a pure water interface 143, the cleaning solution supply pump 321, the first dilution pump pipe 6311 of the dual peristaltic dilution pump 631, and the rinse pump 24 are connected to the pure water interface 143, and the pure water interface 143 is connected to the pure water source 83 to supply pure water. It is understood that a cleaning interface and a dilution interface can also be provided on the interface board 14, the cleaning interface being coupled to a source of cleaning fluid, the dilution interface being coupled to a source of diluent, and both the cleaning fluid supply pump 321 and the flush pump 24 being coupled to the cleaning interface, and the first dilution pump tube 6311 of the dual peristaltic dilution pump 631 being coupled to the dilution interface to supply the cleaning fluid and the diluent.
In an embodiment, please refer to fig. 3 and 4, a plurality of substrate liquid interfaces 141 may be disposed on the interface board 14, where the substrate liquid interfaces 141 correspond to the reactors 51 one by one, for example, in this embodiment, two reactors 51 are provided, the two reactors 51 are a first reactor 51a and a second reactor 51b respectively, the two substrate liquid interfaces 141 are two, the two substrate liquid interfaces 141 are a first substrate liquid interface 141a and a second substrate liquid interface 141b respectively, correspondingly, the two substrate liquid sources 81 are a first substrate liquid source 81a and a second substrate liquid source 81b respectively, the first substrate liquid interface 141a is connected to the first substrate liquid source 81a, and the first pump tube 5411 of the dual peristaltic pump 541 corresponding to the first reactor 51a is connected to the first substrate liquid interface 141 a; the second base solution interface 141b is connected to a second base solution source 81b, and a first pump tube 5411 of the double peristaltic pump 541 corresponding to the second reactor 51b is connected to the second base solution interface 141 b; to facilitate the connection.
In one embodiment, the washing cup 31 and the sample adding cup 41 are integrated to form a combined cup, that is, the washing cavity 311 and the sample adding cavity 411 are formed in one cup body to form a combined cup having functions of the washing cup 31 and the sample adding cup 41, so as to reduce the volume and improve the integration level.
The biochemical analyzer 100 of the embodiment of the application can carry out biochemical analysis to a plurality of components of the sample to detect the ion concentration of the sample, and can accurately control the sampling volume, the used sample volume is less, the used reagent is less, the detection accuracy is high, the detection cost is low, and the efficiency is high.
The above description is only exemplary of the present application and should not be taken as limiting the present application, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims (10)

1. A biochemical analyzer, comprising:
a body;
a sample holder configured to store a reagent tube, the sample holder being mounted on the body;
the sample adding system comprises a sampling needle and a driving mechanism for driving the sampling needle to move, and the driving mechanism is arranged on the machine body;
a plurality of reaction detection systems, each reaction detection system comprising a reactor having a reaction chamber, a detector mounted to a side of each reactor for detecting an analyte sample, each reactor being mounted in the body;
the ion detection system comprises a sample adding cup and an ion concentration testing module, wherein the sample adding cup is used for adding a sample, the ion concentration testing module is used for detecting the ion concentration in the sample, the sample adding cup is communicated with the ion concentration testing module, and the sample adding cup and the ion concentration testing module are installed in the machine body; and the number of the first and second groups,
the cleaning system is configured to clean the sampling needle and comprises a cleaning cup used for enabling the sampling needle to extend into the body for cleaning, and the cleaning cup is installed in the body.
2. The biochemical analyzer of claim 1, wherein: the biochemical analyzer further comprises a dilution system for diluting the sample, the dilution system comprises a dilution cup and a dilution pump set for supplying dilution liquid to the dilution cup and emptying liquid in the dilution cup, and the dilution cup is mounted in the body.
3. The biochemical analyzer of claim 2, wherein: the diluting cup is provided with a diluting cavity, and the diluting cup is provided with an overflow channel for discharging redundant liquid in the diluting cavity, an emptying channel for emptying liquid in the diluting cavity and a liquid injection channel for injecting diluent into the diluting cavity.
4. The biochemical analyzer of any one of claims 1-3, wherein: the driving mechanism comprises a bracket arranged in the machine body, a swing arm supporting the sampling needle, a support rod supporting the swing arm, a lifting driving module driving the support rod to lift and a rotating driving module driving the support rod to rotate, the lifting driving module and the rotating driving module are both arranged on the bracket, and the support rod is movably arranged on the bracket; the sample frame, the plurality of reactors, the sample adding cup and the cleaning cup are arranged around the support rod.
5. The biochemical analyzer of any one of claims 1-3, further comprising:
a standard liquid supply system configured to supply a standard liquid for calibrating each of the detectors; the standard liquid supply system comprises a standard liquid cup used for collecting the standard liquid by the sampling needle, and the standard liquid cup is arranged in the machine body.
6. The biochemical analyzer of claim 5, wherein: the standard liquid supply system also comprises standard liquid pump sets which are used for pumping standard liquid into the standard liquid cavities and emptying the liquid in the recovery cavities.
7. The biochemical analyzer of any one of claims 1-3, wherein: the cleaning system also comprises a cleaning pump set used for pumping cleaning liquid into the cleaning cavity and emptying the liquid in the cleaning cavity.
8. The biochemical analyzer of any one of claims 1-3, wherein: the sample adding system comprises a plunger pump for controlling sample adding of the sampling needle and a washing pump for pumping cleaning liquid to the sampling needle; the inlet of the flushing pump is used for being connected with a cleaning liquid source, the outlet of the flushing pump is communicated with the inlet of the plunger pump, and the outlet of the plunger pump is communicated with the sampling needle.
9. The biochemical analyzer of any one of claims 1-3, wherein: each reaction detection system also comprises a reaction detection pump group used for pumping substrate liquid into the reaction cavity and used for emptying the liquid in the reaction cavity.
10. The biochemical analyzer of any one of claims 1-3, wherein: the ion detection system also comprises a discharge pump for discharging liquid in the sample adding cup, a bidirectional driving pump and a flow path distribution module for controlling various medium sources to be respectively communicated with the bidirectional driving pump, wherein two ends of the bidirectional driving pump are respectively communicated with the flow path distribution module and the ion concentration testing module.
CN202221631012.0U 2022-06-28 2022-06-28 Biochemical analyzer Active CN217212404U (en)

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