CN217140757U

CN217140757U - Plasma separator

Info

Publication number: CN217140757U
Application number: CN202123077795.0U
Authority: CN
Inventors: 傅云毅; 汤耀辉; 韩翔; 邓莉君; 顾凌巍; 方邦江
Original assignee: Shanghai Jiangxia Blood Technology Co Ltd
Current assignee: Shanghai Jiangxia Blood Technology Co Ltd
Priority date: 2021-12-09
Filing date: 2021-12-09
Publication date: 2022-08-09
Anticipated expiration: 2031-12-09

Abstract

The application discloses plasma separator includes: first liquid storage cylinder, first push rod, second liquid storage cylinder and second push rod. The front end part of the first liquid storage cylinder is provided with a blood sampling hole which is communicated with the liquid storage space of the first liquid storage cylinder; the first push rod is inserted into the rear end part of the first liquid storage cylinder and slides along the inner wall of the first liquid storage cylinder in a sealing manner, and the front end part of the first push rod is provided with a first through hole which is communicated with the liquid storage space of the first liquid storage cylinder; the second liquid storage cylinder is inserted into the rear end part of the first push rod, and a second through hole is formed in the front end part of the second liquid storage cylinder and is communicated with the first through hole of the first push rod in a sealing mode; the second push rod is inserted into the rear end part of the second liquid storage cylinder and slides along the inner wall of the second liquid storage cylinder in a sealing manner; and the second push rod is pulled to suck the centrifuged plasma on the upper layer of the first liquid storage cylinder into the second liquid storage cylinder. The plasma separation device can separate plasma and blood cells in a sealed environment, is convenient to operate, and reduces the possibility of pollution.

Description

Plasma separator

Technical Field

The application relates to the technical field of medical equipment, in particular to a plasma separation device.

Background

The whole blood consists of blood cells such as red blood cells, white blood cells and platelets and blood plasma, wherein the blood cells account for 40% -45% of the whole blood, and the blood plasma accounts for 55% -60%. The plasma components are complex and mainly comprise proteins, lipids, inorganic salts, sugars and the like, and many components are directly related to various life activities of the human body. Therefore, the removal of blood cells and the detection and analysis of plasma components are of great significance to both basic biomedical research and clinical detection. Meanwhile, clinical plasma infusion is also an important auxiliary treatment means for clinically curing patients. At present, the most common way to separate plasma is to centrifuge whole blood and obtain plasma by taking the upper layer. However, the current process of collecting the blood plasma inevitably contacts the external environment, thereby causing pollution and influencing the subsequent use.

Disclosure of Invention

The application provides a plasma separator, has reduced the possibility of pollution when carrying out plasma separation, and the simple operation.

The present application provides a plasma separation device comprising: first liquid storage cylinder, first push rod, second liquid storage cylinder and second push rod. The front end part of the first liquid storage cylinder is provided with a blood sampling hole which is communicated with the liquid storage space of the first liquid storage cylinder; the first push rod is in a hollow cylinder shape, is inserted into the rear end part of the first liquid storage cylinder and slides along the inner wall of the first liquid storage cylinder in a sealing way, and is provided with a first through hole at the front end part and communicated with the liquid storage space of the first liquid storage cylinder; the second liquid storage cylinder is inserted into the rear end part of the first push rod, and a second through hole is formed in the front end part of the second liquid storage cylinder, is communicated with the first through hole of the first push rod in a sealing mode and is communicated with a liquid storage space of the second liquid storage cylinder; the second push rod is inserted into the rear end part of the second liquid storage cylinder and slides along the inner wall of the second liquid storage cylinder in a sealing manner; drawing the first push rod, sucking blood into the liquid storage space in the first liquid storage cylinder through the blood sampling hole and storing the blood; after centrifugal treatment, the blood in the liquid storage space of the first liquid storage cylinder forms an upper layer and a lower layer, wherein the upper layer is plasma, and the lower layer is red blood cells; and drawing the second push rod, and sucking the plasma on the upper layer into the liquid storage space of the second liquid storage cylinder.

Optionally, in some embodiments of the present application, a first fixing portion is disposed at a front end portion of the first push rod, the first fixing portion protrudes toward an inside of the first push rod, and the first through hole passes through the first fixing portion and communicates with an inner cavity of the first push rod.

Optionally, in some embodiments of the present application, a second fixing portion is disposed at a front end of the second liquid storage barrel, the second fixing portion protrudes toward an outside of the second liquid storage barrel, and the second through hole passes through the second fixing portion and is communicated with the liquid storage space of the second liquid storage barrel.

Optionally, in some embodiments of the present application, the first fixing portion and the second fixing portion are connected by a screw or a snap.

Optionally, in some embodiments of the present application, the plasma separation device further comprises a plug for sealing the blood collection hole.

Optionally, in some embodiments of the present application, a protruding portion is disposed at a front end of the first liquid storage barrel, the blood sampling hole penetrates through the protruding portion, and the plug is in matching connection with the protruding portion. For example, the plug and the projection may be connected by threads.

Optionally, in some embodiments of the present application, a first groove is provided around a front end of the outer side wall of the first push rod, and a first sealing ring is provided in the first groove.

Optionally, in some embodiments of the present application, a first piston is disposed at a front end of the first push rod, the first piston is integrally connected with the first push rod, a third through hole is disposed on the first piston, and a position of the third through hole corresponds to a position of the first through hole and is communicated with the liquid storage space of the first liquid storage barrel.

Optionally, in some embodiments of the present application, at least one opening is disposed on a side wall of the first push rod; for example, an opening may be disposed on the sidewall of the first push rod, or two opposite openings may be disposed on the sidewall of the first push rod, and the two openings may have the same shape.

Optionally, in some embodiments of the present application, the rear end portion of the first pushing rod is provided with a first holding portion.

Optionally, in some embodiments of the present application, a second groove is provided around a front end of the outer side wall of the second push rod, and a second sealing ring is provided in the second groove.

Optionally, in some embodiments of the present application, a front end portion of the second push rod is provided with a second piston, and the second piston is integrally connected with the second push rod.

Optionally, in some embodiments of the present application, a rear end portion of the second pushing rod is provided with a second holding portion.

The plasma separation device of the application has the following beneficial effects:

the separation of blood cells and plasma is realized through the first push rod of pull and second push rod, and whole operation process all goes on in airtight environment, has completely cut off effectively with the contact of external environment such as air, has avoided the pollution of bacterium and virus to blood, and operation process is simple, and the plasma that follow-up separation is accomplished can directly link to each other with the filter and carries out the filtration of impurity, and need not to shift to other containers, and is high-efficient convenient.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a schematic view of the overall structure of a plasma separation device according to a first embodiment;

FIG. 2 is a schematic structural view of a first liquid storage cylinder according to the first embodiment;

FIG. 3 is a schematic view of a first push rod according to the first embodiment;

FIG. 4 is a schematic structural view of a second liquid storage cylinder according to the first embodiment;

FIG. 5 is a schematic view of a second push rod according to the first embodiment;

FIG. 6 is a schematic view showing a first push rod according to the second embodiment;

FIG. 7 is a schematic view showing a second push rod according to the second embodiment;

FIG. 8 is a schematic view of the plasma separation device after centrifugation;

FIG. 9 is a schematic of blood cell packaging;

figure 10 is a schematic of plasma split charging.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application. Furthermore, it should be understood that the detailed description and specific examples, while indicating exemplary embodiments of the invention, are given by way of illustration and explanation only, and are not intended to limit the scope of the invention. In the present application, unless indicated to the contrary, the use of the directional terms "upper" and "lower" generally refer to the upper and lower positions of the device in actual use or operation, and more particularly to the orientation of the figures of the drawings; while "inner" and "outer" are with respect to the outline of the device.

The embodiment of the application provides a plasma separation device. The following are detailed below. It should be noted that the following description of the embodiments is not intended to limit the preferred order of the embodiments.

The first embodiment,

The plasma separation device provided in this example is as follows:

as shown in fig. 1, the overall view of the plasma separator includes a first reservoir 10, a first push rod 20, a second reservoir 30, and a second push rod 40. The first push rod 20 is inserted into the rear end portion of the first liquid storage cylinder 10 and slides along the inner wall of the first liquid storage cylinder 10 in a sealing manner, the second liquid storage cylinder 30 is inserted into the rear end portion of the first push rod 20, and the second push rod 20 is inserted into the rear end portion of the second liquid storage cylinder 30 and slides along the inner wall of the second liquid storage cylinder 30 in a sealing manner. The plasma separation device may be placed in a centrifuge bowl 60 for centrifugation to separate blood cells from plasma. The plasma separation device further comprises a stopper 50 for sealing the first reservoir 10.

Fig. 2 is a schematic structural diagram of the first liquid storage cylinder 10. The front end of the first liquid storage cylinder 10 is provided with a blood sampling hole 11 which is communicated with the liquid storage space of the first liquid storage cylinder 10, a bulge 12 is arranged around the blood sampling hole 11, and the blood sampling hole 11 penetrates through the bulge 12. The inner peripheral wall of the protruding portion 12 is threaded to be coupled with the plug 50. Alternatively, the projections 12 may be connected to a matching filter or needle.

Fig. 3 is a schematic structural diagram of the first push rod 20. The first push rod 20 is hollow cylinder, and the front end of the first push rod 20 is provided with a first through hole 21 communicated with the liquid storage space of the first liquid storage cylinder 10. The periphery around first through-hole 21 is equipped with first fixed part 22, and first fixed part 22 is protruding towards the inside of first push rod 20, and first through-hole 21 passes first fixed part 22 and communicates with the inner chamber of first push rod 20. A first groove 23 is arranged around the front end of the outer side wall of the first push rod 20, and a first sealing ring 24 is arranged in the first groove 23. The first push rod 20 is provided with a rectangular opening 25 in a side wall thereof. In addition, the rear end of the first push rod is provided with a first grip 26 for facilitating operations such as pushing and pulling.

Fig. 4 is a schematic structural view of the second liquid storage cylinder 30. The front end of the second liquid storage cylinder 30 is provided with a second through hole 31 which is communicated with the first through hole 21 of the first push rod 20 in a sealing manner, and communicated with the liquid storage space of the second liquid storage cylinder 30, a second fixing part 32 is arranged around the periphery of the second through hole 31, the second fixing part 32 protrudes towards the outside of the second liquid storage cylinder 30, the second through hole 31 penetrates through the second fixing part 32 and is communicated with the liquid storage cavity of the second liquid storage cylinder 30, and the first fixing part 22 and the second fixing part 32 are connected through threads. In addition, the second liquid storage cylinder 30 can also be connected with a matched filter or a needle through the second fixing part 32, so as to facilitate the subsequent filtering and back-feeding operation of bacteria, viruses or other impurities.

Fig. 5 is a schematic structural view of the second push rod 40. A second groove 41 is arranged around the front end of the outer side wall of the second push rod 40, and a second sealing ring 42 is arranged in the second groove 41. The second push rod 40 has a second grip 43 at the rear end thereof for easy pushing and pulling.

Example II,

This embodiment provides a plasma separation device as follows:

the difference between the first embodiment and the first embodiment is that the first push rod and the second push rod of the present embodiment replace the sealing ring with the piston, so that the first push rod and the second push rod are more convenient to move and have stronger sealing performance.

Fig. 6 is a schematic structural diagram of the first push rod 20. The first push rod 20 is a hollow cylinder, and a first through hole 21 is formed in the front end of the first push rod 20 and is communicated with the liquid storage space of the first liquid storage cylinder 10. The periphery around first through-hole 21 is equipped with first fixed part 22, and first fixed part 22 is protruding towards the inside of first push rod 20, and first through-hole 21 passes first fixed part 22 and communicates with the inner chamber of first push rod 20. A rectangular opening 25 is provided in the side wall of the first push rod. In addition, the rear end of the first push rod is provided with a first grip 26 for facilitating operations such as pushing and pulling. The front end of the first push rod is provided with a first piston 27, the first piston 27 is integrally connected with the first push rod 20, the first piston 27 is provided with a third through hole, and the position of the third through hole corresponds to the position of the first through hole 21.

Fig. 7 is a schematic structural view of the second push rod 40. The rear end of the second push rod is provided with a second holding part 43 for facilitating push-pull operation and the like. The front end of the second push rod is provided with a second piston 44, and the second piston 44 is integrally connected with the second push rod 40.

The rest of the components of the plasma separation device are the same as those of the first embodiment, and are not described in detail herein.

EXAMPLE III plasma separation protocol

In this embodiment, the plasma separation device is used to separate blood cells from plasma, and includes the following steps:

1) blood collection: connecting a blood sampling hole with an external blood sampling needle, drawing a first push rod to collect blood, taking down the blood sampling needle after the collection is finished, and screwing a plug;

2) centrifugal separation: placing the plasma separation device in a centrifugal cylinder of a centrifuge along the vertical direction, wherein a blood sampling hole is downward, adding physiological saline with corresponding weight by using a balance tube for balancing, and performing centrifugal separation until blood is separated into layers, wherein the centrifuged plasma separation device is shown in figure 8, the upper layer is plasma and the lower layer is blood cells after centrifugation;

3) subpackaging plasma blood cells: get out plasma separator from centrifuge, through pull second push rod, will be located the plasma suction second liquid storage cylinder of first liquid storage cylinder upper strata after the centrifugation in, what stayed at this moment in the first liquid storage cylinder is the blood cell, what inhaled the second liquid storage cylinder is plasma. Unscrewing the second liquid storage cylinder from the first push rod, thereby completing the subpackaging of the plasma and the blood cells, as shown in fig. 9 and fig. 10, the blood cells are in the first liquid storage cylinder, and the plasma is in the second liquid storage cylinder;

4) blood cells can be subsequently transfused after the blood sampling hole of the first liquid storage cylinder is externally connected with the needle head, and the second fixing part of the second liquid storage cylinder is connected with the matched filter to filter viruses or bacteria.

The application provides a plasma separator, follow blood collection, centrifugal separation, plasma blood cell partial shipment follow-up operation and all go on in airtight environment, prevent the emergence of pollution, and the operation process is convenient, has avoided shifting blood in a plurality of containers.

The present invention provides a plasma separation device, which is described in detail above, and the principle and the embodiments of the present invention are described herein by using specific examples, and the description of the above examples is only used to help understand the method and the core concept of the present invention; meanwhile, for those skilled in the art, according to the idea of the present application, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present application.

Claims

1. A plasma separation device, comprising:

the blood sampling device comprises a first liquid storage cylinder, a second liquid storage cylinder and a blood sampling device, wherein the front end part of the first liquid storage cylinder is provided with a blood sampling hole and is communicated with a liquid storage space of the first liquid storage cylinder;

the first push rod is in a hollow cylindrical shape, the first push rod is inserted into the rear end portion of the first liquid storage cylinder and slides in a sealing mode along the inner wall of the first liquid storage cylinder, a first through hole is formed in the front end portion of the first push rod and is communicated with the liquid storage space of the first liquid storage cylinder, a first fixing portion is arranged at the front end portion of the first push rod and protrudes towards the interior of the first push rod, and the first through hole penetrates through the first fixing portion and is communicated with the inner cavity of the first push rod;

the second liquid storage cylinder is inserted into the rear end part of the first push rod, a second through hole is formed in the front end part of the second liquid storage cylinder, the second through hole is communicated with the first through hole of the first push rod in a sealing mode and is communicated with a liquid storage space of the second liquid storage cylinder, a second fixing part is arranged at the front end part of the second liquid storage cylinder, the second fixing part protrudes towards the outside of the second liquid storage cylinder, and the second through hole penetrates through the second fixing part and is communicated with the liquid storage space of the second liquid storage cylinder; and

and the second push rod is inserted into the rear end part of the second liquid storage cylinder and slides along the inner wall of the second liquid storage cylinder in a sealing manner.

2. The plasma separation device of claim 1, wherein the first and second securing portions are threaded or snap-fit.

3. The plasma separator device according to claim 1, further comprising a stopper sealing the blood collection hole.

4. The plasma separator according to claim 3, wherein the front end of the first reservoir is provided with a protrusion, the blood sampling hole passes through the protrusion, and the plug is connected with the protrusion in a matching manner.

5. The plasma separator device according to claim 1, wherein a first groove is formed around the front end of the outer side wall of the first push rod, and a first sealing ring is arranged in the first groove.

6. The plasma separation device according to claim 1, wherein a first piston is arranged at the front end of the first push rod, the first piston is integrally connected with the first push rod, a third through hole is arranged on the first piston, and the position of the third through hole corresponds to the position of the first through hole and is communicated with the liquid storage space of the first liquid storage cylinder.

7. The plasma separator device according to claim 1, wherein the first push rod is provided with at least one opening on a side wall thereof.

8. The plasma separator according to claim 1, wherein the rear end of the first push rod is provided with a first grip portion.

9. The plasma separator device according to claim 1, wherein a second groove is formed around the front end of the outer side wall of the second push rod, and a second sealing ring is arranged in the second groove.

10. The plasma separating device according to claim 1, wherein the front end of the second push rod is provided with a second piston, and the second piston is integrally connected with the second push rod.

11. The plasma separator according to claim 1, wherein the rear end of the second push rod is provided with a second grip portion.