CN217138809U

CN217138809U - Plasma filters external member

Info

Publication number: CN217138809U
Application number: CN202123077988.6U
Authority: CN
Inventors: 汤耀辉; 董强; 陈豪; 陆雪峰; 李飒
Original assignee: Shanghai Jiangxia Blood Technology Co Ltd
Current assignee: Shanghai Jiangxia Blood Technology Co Ltd
Priority date: 2021-12-09
Filing date: 2021-12-09
Publication date: 2022-08-09
Anticipated expiration: 2031-12-09

Abstract

The application discloses a plasma filters external member, includes plasma extraction element and filter. The plasma extraction device includes: a first syringe, a first ram, a second syringe, and a second ram. The front end part of the first needle cylinder is provided with a first connecting part; the first push rod is inserted into the rear end part of the first needle cylinder and slides along the inner wall of the first needle cylinder in a sealing way, and the front end part of the first push rod is provided with a first through hole; the front end part of the second needle cylinder is provided with a second connecting part, a second through hole penetrates through the second connecting part, and the second through hole is communicated with the first through hole of the first push rod in a sealing way; the second push rod is inserted in the back end of the second needle cylinder and slides along the inner wall of the second needle cylinder in a sealing way. The filter has into blood mouth, advances blood mouth and first connecting portion and/or second connecting portion accordant connection, filters the blood in first syringe and the second syringe. The plasma filter kit can separate and filter plasma in a closed environment, is convenient to operate, and reduces the possibility of pollution.

Description

Plasma filters external member

Technical Field

The application relates to the technical field of medical equipment, in particular to a plasma filtering kit.

Background

At present, the transfusion after blood filtration is a quite common treatment mode, and in a laboratory, the blood plasma is often filtered and then further research is carried out. However, the extraction and separation of the plasma and the filtration are usually performed separately, and the plasma is often transferred to another container for filtration after the extraction, so the operation process is complicated, and the pollution is easily introduced.

Disclosure of Invention

The application provides a plasma filters external member, can separate and filter plasma in airtight environment, has reduced the possibility of pollution, and the simple operation.

The present application provides a plasma filtration kit comprising a plasma extraction device and a filter. The plasma extraction device includes: a first syringe, a first ram, a second syringe, and a second ram. The front end part of the first needle cylinder is provided with a first connecting part, the first connecting part protrudes towards the outer part of the first needle cylinder, a liquid outlet hole is arranged through the first connecting part, and the liquid outlet hole is communicated with the inner cavity of the first needle cylinder; the first push rod is hollow and cylindrical, is inserted into the rear end part of the first needle cylinder and slides along the inner wall of the first needle cylinder in a sealing way, and is provided with a first through hole at the front end part and communicated with the inner cavity of the first needle cylinder; the second needle cylinder is inserted into the rear end part of the first push rod, the front end part of the second needle cylinder is provided with a second connecting part, the second connecting part protrudes towards the outside of the second needle cylinder, a second through hole penetrates through the second connecting part, and the second through hole is communicated with the first through hole of the first push rod in a sealing manner and is communicated with an inner cavity of the second needle cylinder; the second push rod is inserted in the back end of the second needle cylinder and slides along the inner wall of the second needle cylinder in a sealing way. The filter is provided with a blood inlet which is matched and connected with the first connecting part and/or the second connecting part. Drawing the first push rod, sucking blood into the inner cavity of the first syringe through the liquid outlet hole and storing the blood; after centrifugal treatment, the blood in the inner cavity of the first needle cylinder forms an upper layer and a lower layer, wherein the upper layer is blood plasma, and the lower layer is red blood cells; the second push rod is pulled, and the plasma on the upper layer is sucked into the inner cavity of the second syringe. The plasma extraction device is directly connected with the filter, and the whole blood in the first needle cylinder is pushed into the filter by pushing the first push rod, so that the whole blood can be filtered; the plasma after centrifugation can be sucked into the second syringe by drawing the second push rod, the second connecting part of the second syringe is connected with the filter, and the plasma in the second syringe is pushed into the filter by pushing the second push rod, so that the plasma is filtered.

Optionally, in some embodiments of the present application, the filter includes a first housing and a second housing. The first shell is provided with a blood inlet and an opening part, and the blood inlet is communicated with the opening part; the second shell and the first shell form an accommodating space, and a bleeding opening is formed in the second shell and on the surface opposite to the first shell. In the receiving space, a filter membrane is placed on the bottom surface of the second housing, and filtration of bacteria, viruses, or other impurities can be performed by providing the corresponding filter membrane.

Optionally, in some embodiments of the present application, the first connection portion is threadedly connected to the blood inlet port.

Optionally, in some embodiments of the present application, the second connection portion is threadedly connected to the blood inlet.

Optionally, in some embodiments of the present application, the opening size of the opening portion decreases toward the place where the blood inlet port communicates. The opening part is in a shape with a small upper part and a big lower part so as to uniformly drain the blood to the filter membrane.

Optionally, in some embodiments of the present application, the second housing has a plurality of divergent drainage grooves on an inner surface thereof opposite to the first housing for introducing the filtered plasma into the bleeding ports.

Optionally, in some embodiments of the present application, the filter further includes a casing surrounding and covering the sides of the first casing and the second casing to fixedly connect the first casing and the second casing.

Optionally, in some embodiments of the present application, the inner side of the shell is threadedly connected with the outer side of the second shell.

Optionally, in some embodiments of the present application, a fixing portion is disposed at a front end portion of the first push rod, the fixing portion protrudes toward an inside of the first push rod, and the first through hole penetrates through the fixing portion and is communicated with an inner cavity of the first push rod.

Alternatively, in some embodiments of the present application, the fixing portion and the second connecting portion may be connected by a screw or a snap, so that the second syringe can be detachably fixed to the first push rod.

Optionally, in some embodiments of the present application, a first groove is disposed around a front end of an outer side wall of the first push rod, and a first sealing ring is disposed in the first groove to seal an internal environment of the first syringe.

Optionally, in some embodiments of the present application, at least one opening is disposed on a side wall of the first push rod; for example, an opening may be disposed on the sidewall of the first push rod, or two opposite openings may be disposed on the sidewall of the first push rod, and the two openings may have the same shape.

Optionally, in some embodiments of the present application, a second groove is provided around the front end of the outer sidewall of the second plunger, and a second sealing ring is provided in the second groove to seal the internal environment of the second syringe.

The plasma filter kit of the present application has the following beneficial effects:

the plasma extraction device is directly connected with the filter, and the whole blood can be filtered by pushing the first push rod; meanwhile, the second push rod is pulled, the centrifuged plasma on the upper layer of the first syringe is sucked into the second syringe, the second connecting part of the second syringe is connected with the filter, and the plasma is filtered by pushing the second push rod. This plasma filters external member can realize that the separation of plasma draws and filterable link up fast, has avoided still needing to carry out operations such as a series of shifts after having drawed plasma, and whole operation process all goes on in airtight environment, has completely cut off effectively with the contact of external environment such as air, has reduced the emergence of pollution, and operation process is simple.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a schematic view of the whole structure of a plasma extraction device;

FIG. 2 is a schematic view of a first syringe configuration;

FIG. 3 is a schematic view of a first push rod structure;

FIG. 4 is a schematic view of a second syringe structure;

FIG. 5 is a schematic view of a second pushrod configuration;

FIG. 6 is a schematic view of a filter construction;

FIG. 7 is a schematic view of a first syringe and filter connection;

fig. 8 is a schematic view of the second syringe and filter connection.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application. Furthermore, it should be understood that the detailed description and specific examples, while indicating exemplary embodiments of the invention, are given by way of illustration and explanation only, and are not intended to limit the scope of the invention. In the present application, unless indicated to the contrary, the use of the directional terms "upper" and "lower" generally refer to the upper and lower positions of the device in actual use or operation, and more particularly to the orientation of the figures of the drawings; while "inner" and "outer" are with respect to the outline of the device.

The embodiment of the application provides a plasma filtering kit. The following are detailed below. It should be noted that the following description of the embodiments is not intended to limit the preferred order of the embodiments.

The first embodiment,

The present embodiment provides a preferred embodiment of a plasma filtration kit.

The plasma filtration kit includes a plasma extraction device and a filter.

Referring to fig. 1, the overall view of the plasma extraction device 10 is shown, and the plasma extraction device includes a first syringe 20, a first push rod 30, a second syringe 40, and a second push rod 50. The first push rod 30 is inserted into the rear end portion of the first cylinder 20 and sealingly slides along the inner wall of the first cylinder 20, the second cylinder 40 is inserted into the rear end portion of the first push rod 30, and the second push rod 50 is inserted into the rear end portion of the second cylinder 40 and sealingly slides along the inner wall of the second cylinder 40. The plasma extraction device may be placed in a centrifuge bowl 70 for centrifugation to separate blood cells from plasma. The plasma extraction device 10 may further include a stopper 60 that seals the first syringe 20.

Fig. 2 is a schematic structural view of the first syringe 20. The front end of the first syringe 20 is provided with a first connecting part 21, the first connecting part 21 protrudes towards the outside of the first syringe 20, a liquid outlet 22 is arranged through the first connecting part 21, and the liquid outlet 22 is communicated with the inner cavity of the first syringe 20. The inner peripheral side wall of the first connecting portion 21 is provided with threads, and can be connected with the filter in a matched mode, and the first connecting portion 21 can also be connected with the plug in a matched mode.

Fig. 3 is a schematic structural diagram of the first push rod 30. The first push rod 30 is hollow and cylindrical, a fixing portion 31 is arranged at the front end portion of the first push rod, the fixing portion 31 protrudes towards the inside of the first push rod 30, and the first through hole 32 penetrates through the fixing portion 31 and is communicated with the inner cavities of the first push rod 30 and the first syringe 20. A first groove 34 is arranged around the front end of the outer side wall of the first push rod 30, and a first sealing ring 35 is arranged in the first groove 34. The first push rod 30 is provided with a rectangular opening 33 in a side wall thereof.

Fig. 4 shows a schematic structure of the second syringe 40. The front end of the second needle cylinder 40 is provided with a second connecting part 41, the second connecting part 41 protrudes towards the outside of the second needle cylinder 40, the second through hole 42 passes through the second connecting part 41 and is communicated with the inner cavity of the second needle cylinder 40, and the second through hole 42 is communicated with the first through hole 32 of the first push rod 30 in a sealing way. The second connecting portion 41 is threadedly coupled to the fixing portion 31 of the first ram 30 so that the second syringe 40 is detachably fixed to the first ram 30. In addition, the second syringe 40 can also be connected with the filter of the present application through the screw thread of the inner peripheral sidewall of the second connecting portion 41, so as to facilitate the subsequent filtering operation of bacteria, viruses or other impurities.

Fig. 5 is a schematic structural view of the second push rod 50. A second groove 51 is arranged around the front end of the outer side wall of the second push rod 50, and a second sealing ring 52 is arranged in the second groove 51.

Fig. 6 shows a schematic structure of the filter 80. The filter 80 includes a first housing 81 and a second housing 82. The first housing 81 is provided with a blood inlet 84 and an opening 85, the blood inlet 84 and the opening 85 are communicated, and the opening 85 is reduced in size toward the communication portion with the blood inlet 84. The second housing 82 and the first housing 81 form an accommodating space, a bleeding opening 86 is formed on the second housing 82 opposite to the first housing 81, and a plurality of divergent drainage grooves 87 are formed on the inner surface of the second housing 82 opposite to the first housing 81, so that the filtered plasma is introduced into the bleeding opening 86. In the accommodating space formed by the first housing 81 and the second housing 82, a filter membrane is placed on the bottom surface of the second housing 82, and filtration of bacteria, viruses, or other impurities can be performed by providing the respective filter membranes. The filter further comprises a shell 83, the shell 83 surrounds and covers the side surfaces of the first shell 81 and the second shell 82 so as to fixedly connect the first shell 81 and the second shell 82, and the inner side surface of the shell 83 is in threaded connection with the outer side surface of the second shell 82.

The peripheral side wall of the blood inlet 84 of the filter is provided with threads which can be in threaded connection with the first connecting part 21 or the second connecting part 41 of the plasma extracting device 10 to form a plasma filtering kit for extracting and filtering blood or plasma.

Example two procedure for plasma filtration

This embodiment uses a plasma filtration kit for blood and plasma filtration, comprising the steps of:

1) blood collection: connecting the first connecting part with an external blood taking needle, drawing the first push rod to collect blood, taking down the blood taking needle after the collection is finished, connecting the first connecting part of the first syringe with the blood inlet of the filter, and pushing the first push rod 30 to filter as shown in fig. 7; or connecting the first connecting part with the plug for subsequent centrifugal separation;

2) centrifugal separation: placing the plasma extraction device in a centrifugal cylinder of a centrifugal machine along the vertical direction, wherein a liquid outlet hole is downward, adding physiological saline with corresponding weight by using a balance tube for balance, and performing centrifugal separation until blood is separated into layers, wherein the upper layer is plasma and the lower layer is blood cells;

3) subpackaging plasma blood cells: and taking the plasma extraction device out of the centrifuge, drawing the second push rod, sucking the centrifuged plasma on the upper layer of the first syringe into the second syringe, wherein blood cells are remained in the first syringe at the moment, and the plasma is sucked into the second syringe. Unscrewing the second syringe from the first push rod, thereby completing the subpackaging of the plasma and the blood cells;

4) subsequently, the first connection part of the first syringe is externally connected with a needle and then blood cells are returned, the second connection part of the second syringe is connected with a matched filter, as shown in fig. 8, the second push rod 50 is pushed, the blood plasma in the second syringe 40 is pushed into the filter 80, and viruses or bacteria are filtered after passing through the filter membrane.

The application provides a plasma filters external member, can link up the collection, the extraction and the filtration of blood fast, above operation all goes on in airtight environment, prevents the emergence of pollution, and the operation process is convenient, has avoided shifting blood in a plurality of containers.

The present application provides a plasma filtration kit, and the principle and embodiments of the present application are described herein by using specific examples, and the description of the examples is only used to help understand the method and the core concept of the present application; meanwhile, for those skilled in the art, according to the idea of the present application, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present application.

Claims

1. A plasma filtration kit comprising a plasma extraction device and a filter;

the plasma extraction device comprises:

the front end part of the first needle cylinder is provided with a first connecting part, the first connecting part protrudes towards the outer part of the first needle cylinder, a liquid outlet hole penetrates through the first connecting part, and the liquid outlet hole is communicated with an inner cavity of the first needle cylinder;

the first push rod is hollow and cylindrical, is inserted into the rear end part of the first needle cylinder and slides along the inner wall of the first needle cylinder in a sealing manner, and is provided with a first through hole at the front end part and communicated with the inner cavity of the first needle cylinder;

the second needle cylinder is inserted into the rear end part of the first push rod, a second connecting part is arranged at the front end part of the second needle cylinder, the second connecting part protrudes towards the outside of the second needle cylinder, a second through hole penetrates through the second connecting part, and the second through hole is hermetically communicated with the first through hole of the first push rod and is communicated with an inner cavity of the second needle cylinder; and

the second push rod is inserted into the rear end part of the second needle cylinder and slides along the inner wall of the second needle cylinder in a sealing manner;

the filter is provided with a blood inlet which is matched and connected with the first connecting part and/or the second connecting part.

2. The plasma filtration kit of claim 1, wherein the filter comprises:

a first housing provided with the blood inlet and an opening portion, the blood inlet and the opening portion being communicated; and

the second shell and the first shell form an accommodating space, and a blood outlet is formed in the surface, opposite to the first shell, of the second shell.

3. The plasma filtration kit of claim 1, wherein the first connection portion is threadably connected to the blood inlet port.

4. The plasma filtration kit of claim 1, wherein the second connection portion is threadably connected to the blood inlet port.

5. The plasma filtration kit of claim 2, wherein the opening size of the opening portion decreases toward a place where it communicates with the blood inlet port.

6. The plasma filtration kit of claim 2, wherein the second housing has a plurality of diverging drainage slots on an inner surface thereof opposite the first housing for introducing filtered plasma into the bleeding port.

7. The plasma filtration kit of claim 2, wherein the filter further comprises a shell that surrounds sides of the first and second housings to fixedly connect the first and second housings.

8. The plasma filtration kit of claim 7, wherein an inner side of the shell is threadably connected with an outer side of the second housing.

9. The plasma filter kit according to claim 1, wherein the front end of the first push rod is provided with a fixing portion protruding toward the inside of the first push rod, and the first through hole passes through the fixing portion and communicates with the inner cavity of the first push rod.

10. The plasma filtration kit of claim 9, wherein the fixation portion and the second connection portion are connected by a threaded connection or a snap connection.

11. The plasma filter kit of claim 1, wherein a first groove is disposed around a front end of an outer sidewall of the first push rod, and a first sealing ring is disposed in the first groove.

12. The plasma filtration kit of claim 1, wherein the first pushrod has at least one opening in a sidewall thereof.

13. The plasma filter kit of claim 1, wherein a second groove is provided around the front end of the outer sidewall of the second push rod, and a second sealing ring is provided in the second groove.