CN217015066U

CN217015066U - Nano-chip

Info

Publication number: CN217015066U
Application number: CN202123309085.6U
Authority: CN
Inventors: 不公告发明人
Original assignee: Suzhou Nanomed Biomed Co ltd
Current assignee: Suzhou Nanomed Biomed Co ltd
Priority date: 2021-12-27
Filing date: 2021-12-27
Publication date: 2022-07-22
Anticipated expiration: 2031-12-27

Abstract

The utility model discloses a nano wafer, which comprises a substrate and a micro needle array positioned on the substrate, wherein the micro needle array comprises a plurality of micro needles, and the ratio of the maximum value to the minimum value of the height of the micro needles in the micro needle array is more than 1 and less than 1000. The beneficial effects of the utility model are as follows: the microneedles with various heights are integrated on one nano wafer, and the nano wafer can form channels with various depths after acting on the skin, so that the medicaments and the nutrient substances can reach skin tissues with different depths through the channels, and can simultaneously act on the skin tissues at the layers to achieve the effect of composite treatment or maintenance.

Description

Nano-chip

Technical Field

The utility model belongs to the technical field of microneedles, and particularly relates to a nano wafer.

Background

The nano-chip is a novel transdermal drug delivery device. The surface of the nanometer chip is integrated with micro needle arrays which can open the skin barrier and promote the absorption of medicines and nutrient substances, and the nanometer chip has the characteristics of no pain and no wound in the using process and is widely applied to the fields of medical treatment and beauty and skin care. For example, patent CN1562402A discloses a microneedle array chip made of metal material.

In the existing nano-chip, the tips of the microneedles in the microneedle array are generally in the same plane, and the nano-chip forms channels after acting on the skin, the depth of the channels is the same, and the drugs and nutrients enter the tissues of the skin with the same depth through the channels.

However, in some application scenarios, it is desirable that the drugs and nutrients can enter different depths of skin tissue, thereby acting simultaneously on multiple layers of skin tissue. The structure of the existing nano-chip can not realize the requirement.

Disclosure of Invention

The utility model aims to provide a nano chip which can act on multi-layer skin tissues simultaneously.

In order to solve the technical problems, the utility model adopts the technical scheme that: a nano wafer comprises a substrate and a micro needle array positioned on the substrate, wherein the micro needle array comprises a plurality of micro needles, and the ratio of the maximum value to the minimum value of the height of the micro needles in the micro needle array is more than 1 and less than 1000.

Preferably, the ratio of the maximum to minimum height of the microneedles in the microneedle array ranges from 1.1 to 500.

Preferably, the ratio of the maximum to minimum of the height of the microneedles in the microneedle array is in the range of 1.1 to 100.

Preferably, the ratio of the maximum to minimum height of the microneedles in the microneedle array ranges from 1.1 to 5.

Preferably, the height of the microneedles in the microneedle array is increased or decreased in no more than four directions from any position.

Preferably, the height of the microneedles in the microneedle array is changed in a stepwise manner along no more than four directions from any position.

Preferably, the height of the microneedles in the microneedle array varies periodically in one direction or two directions.

Preferably, the materials of the microneedle array and the substrate are monocrystalline silicon, metal materials or high molecular materials.

The utility model has the beneficial effects that: the microneedles with various heights are integrated on one nano wafer, and the nano wafer can form channels with various depths after acting on the skin, so that the medicaments and the nutrient substances can reach skin tissues with different depths through the channels, and can simultaneously act on the skin tissues at the layers to achieve the effect of composite treatment or maintenance.

Drawings

Fig. 1 is a schematic structural diagram of a first embodiment of the present invention.

Fig. 2 is a schematic structural diagram of a second embodiment of the present invention.

Fig. 3 is a schematic structural diagram of a third embodiment of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.

Example one

As shown in fig. 1, the nano-wafer includes a substrate 1 and a micro-needle array 2 disposed on the substrate 1, and the micro-needle array 2 and the substrate 1 are integrally formed of single crystal silicon or a metal material. The microneedle array 2 comprises a plurality of microneedles, the height of the microneedles in the microneedle array 2 is gradually reduced along the direction of two adjacent edges of the substrate by taking the first microneedle at the upper left in the figure as a starting point, and a blank area without the microneedles is formed at the lower right corner of the substrate. The maximum height of the microneedles in the microneedle array is 1mm, the minimum height of the microneedles is 0.01mm, and the ratio is 100.

The 1mm microneedle can reach deeper skin tissues, the 0.01mm microneedle hardly influences the skin, and the microneedle with the middle height can reach shallower skin tissues.

Example two

The height of the microneedles in the microneedle array 2 decreases in only one direction. The direction can be the direction of any side of the substrate of the nano-chip, the diagonal direction of the substrate of the nano-chip, or any other direction.

EXAMPLE III

As shown in fig. 2, the nano wafer comprises a substrate 1 and a microneedle array 2 located on the substrate 1, the microneedle array 2 comprises a plurality of microneedles, the height of the microneedles in the microneedle array 2 is decreased from left to right every three columns into a group, the height of the microneedles in the group is decreased, the height of the microneedles in the initial column of each group is the same, and the height of the microneedles in each column is the same. The maximum value of the height of the microneedles in the microneedle array is 1mm, the minimum value of the height of the microneedles is 0.2mm, and the ratio is 5.

Example four

Every two microneedles in the microneedle array 2 are in a group in two directions, the height of the microneedles in the group is gradually reduced, the height of the first microneedle in each group is the same, and the microneedles in each direction are in a zigzag shape.

EXAMPLE five

As shown in fig. 3, the nano-wafer includes a substrate 1 and a microneedle array 2 located on the substrate 1, the microneedle array 2 includes a plurality of microneedles, every three microneedles in the microneedle array 2 are in a group in the direction of two adjacent edges of the substrate, the height of the microneedles in each group is the same, and the height of the microneedles in each group is decreased progressively. The maximum height of the microneedles in the microneedle array is 1.5mm, the minimum height is 0.3mm, and the ratio is 5.

EXAMPLE six

Every three or four microneedles in the microneedle array 2 form a group along one direction, the height of the microneedles in each group is the same, and the height of the microneedles in each group is gradually reduced.

In the above embodiments, the microneedle arrays are all arranged at equal intervals, and in other embodiments, the microneedle arrays may have different intervals.

In the above embodiments, the widths of the microneedle bases are all the same, and in other embodiments, the widths of the microneedle bases may also be different.

The above embodiments show the number and distribution of microneedles of different heights in some nanocrystals, which may affect the absorption of the active ingredient, and the number and distribution of microneedles of different heights in the nanocrystals may be designed according to the ratio and expected effect of each component in the active ingredient.

In the above embodiments, the shape of the microneedles is quadrangular pyramid, and in other embodiments, the shape of the microneedles may be other shapes, such as conical, blade-shaped, octagonal pyramid, and the like. The surface of the micro-needle, such as the side surface, can also be provided with structures such as a liquid storage tank, a groove and the like so as to increase the capability of the micro-needle for carrying liquid medicine.

The nano wafer can be made of monocrystalline silicon, metal materials or high polymer materials, is applied to permeation promoting equipment such as a permeation promoting instrument, a water light machine and the like, is matched with products such as liquid medicine, essence and the like to be used for promoting the absorption of the products, and can also be made of high polymer materials such as hyaluronic acid.

When the ratio of the maximum value to the minimum value of the height of the microneedles in the microneedle array is 1000, the minimum height of the microneedles in the microneedle array is not more than 0.002mm because the height of the microneedles is not more than 2mm generally, and the thickness of the human skin stratum corneum is between 0.005 mm and 0.025mm generally, at this moment, the microneedles with the minimum height cannot open the skin stratum corneum to form a channel and cannot substantially affect the skin stratum corneum. For example, when treating pregnancy striae, the microneedle with the smallest height can be selected to act on a good skin, and the microneedle with the highest height can act on the skin, so that the effect of not affecting normal skin can be achieved when treating pregnancy striae.

Claims

1. A nano wafer comprises a substrate and a micro needle array positioned on the substrate, wherein the micro needle array comprises a plurality of micro needles, and the ratio of the maximum value to the minimum value of the height of the micro needles in the micro needle array is more than 1 and less than 1000.

2. The nanocrystal sheet of claim 1, wherein the ratio of the maximum to minimum height of the microneedles in the microneedle array ranges from 1.1 to 500.

3. The nanocrystal sheet of claim 1, wherein the ratio of the maximum to minimum height of the microneedles in the microneedle array ranges from 1.1 to 100.

4. The nanocrystal sheet of claim 1 wherein the microneedle array has a ratio of a maximum height to a minimum height of microneedles in the range of 1.1 to 5.

5. The nano-wafer according to claim 1, wherein the height of the micro-needle in the micro-needle array is increased or decreased along no more than four directions from any position as a starting point.

6. The nano-wafer according to claim 1, wherein the height of the micro-needle in the micro-needle array is changed stepwise in no more than four directions from any position as a starting point.

7. The nanocrystal wafer of claim 1, wherein the height of the microneedles in the microneedle array varies periodically in one or both directions.

8. The nano-wafer according to claim 1, wherein the materials of the micro-needle array and the substrate are single crystal silicon, metal materials or high molecular materials.