CN216192370U - Nucleic acid extraction device of magnetic bead method liquid separation extraction instrument - Google Patents
Nucleic acid extraction device of magnetic bead method liquid separation extraction instrument Download PDFInfo
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- CN216192370U CN216192370U CN202121950799.2U CN202121950799U CN216192370U CN 216192370 U CN216192370 U CN 216192370U CN 202121950799 U CN202121950799 U CN 202121950799U CN 216192370 U CN216192370 U CN 216192370U
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Abstract
The utility model relates to a nucleic acid extraction device of a magnetic bead method liquid separation extraction instrument, which comprises a magnetic rod linear motion mechanism, wherein the magnetic rod linear motion mechanism is arranged on a ball screw linear module, a magnetic sleeve is arranged below the magnetic rod linear motion mechanism on the ball screw linear module, the magnetic rod linear motion mechanism and the magnetic sleeve can move up and down relative to the ball screw linear module, a magnetic rod is fixedly arranged on the magnetic rod linear motion mechanism, the magnetic rod can be inserted into the magnetic sleeve, and the magnetic rod linear motion mechanism drives the magnetic rod to move up and down relative to the magnetic sleeve; the magnetic rod is provided with a plurality of rod bodies along the width direction of the kit, and the magnetic sleeves and the rod bodies of the magnetic rod are in the same number and are arranged in one-to-one correspondence.
Description
Technical Field
The utility model belongs to the technical field of magnetic bead extraction and purification, and particularly relates to a nucleic acid extraction device of a magnetic bead method liquid separation extraction instrument.
Background
The automation part of the existing magnetic bead extraction and purification technology mainly focuses on the extraction stage, namely, an extraction reagent is manually added into a deep-well plate, and after the addition of the extraction reagent is completed each time, the deep-well plate with the reagent is placed into a (nucleic acid) extractor for cracking, washing, vulcanizing, eluting and the like. When the working properties of the reagents are different, (such as adding new reagents in the midway), the operation needs to be interrupted in the automatic extraction process, and manual intervention is carried out, so that personnel need to pay attention to the working process at any time, the normal extraction process cannot be influenced by artificial participation, otherwise, the smoothness of the extraction process is insufficient, and result deviation is easy to generate, and even extraction failure is easy to occur.
In addition, the existing (nucleic acid) extractor in the market is mainly divided into two specifications, namely a small-flux (nucleic acid) extractor and a large-flux (nucleic acid) extractor; the small-flux (nucleic acid) extractor is used under the condition of small number of samples per day, when the number of the samples is small, the extraction operation can be carried out at any time without accumulating enough samples and then carrying out the operation, and the result can be conveniently and quickly obtained. When the number of samples per day is too large, the small-flux (nucleic acid) extractor cannot meet the requirement of extraction detection, so that a large-flux (nucleic acid) extractor is needed, but when the number of samples is not fixed, the large-flux (nucleic acid) extractor cannot meet the requirement of small-flux test, so that reagent waste is generated, and the small-flux or large-flux (nucleic acid) extractor cannot be used under the condition that the number of samples per day is not fixed. Meanwhile, due to different use conditions of the reagents, the extraction process of some reagents is very long, and several samples cannot be extracted in one day when the flux is too small, so that a (nucleic acid) extractor with large flux is also needed in the condition.
For the analysis of the above situations, the following problems need to be solved in the magnetic bead extraction and purification technology: firstly, the situation that manual liquid adding is carried out when the reagent is stopped halfway due to the requirement of the working condition of the reagent needs to be reduced. Secondly, the (nucleic acid) extractor with the largest flux is selected as much as possible, so that the situation that the sample extraction is insufficient and the working efficiency is low due to the fact that the sample amount is too large or the reagent extraction time is too long is prevented. Thirdly, the situation that a large amount of samples must be extracted at one time by a large-flux (nucleic acid) extractor in the market needs to be improved, and the situation that reagents are excessively wasted when the amount of the samples is insufficient is prevented. Fourthly, a follow-up detection function scheme is required to be added, so that the next round of nucleic acid extraction process can be conveniently carried out by utilizing the rest non-working flux in the nucleic acid extraction process.
Especially, for nucleic acid extraction of a magnetic bead method liquid separation extractor, a nucleic acid extraction device with wide applicability and convenient extraction needs to be designed.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a nucleic acid extraction device of a magnetic bead method liquid separation extraction instrument, which has the advantages of ingenious structure, convenient action, smoothness and effectiveness.
In order to achieve the above purpose, the utility model adopts the technical scheme that: a nucleic acid extraction device of a magnetic bead method liquid separation extraction instrument comprises a magnetic rod linear motion mechanism, wherein the magnetic rod linear motion mechanism is arranged on a ball screw linear module, a magnetic sleeve is arranged below the magnetic rod linear motion mechanism on the ball screw linear module, the magnetic rod linear motion mechanism and the magnetic sleeve can move up and down relative to the ball screw linear module, a magnetic rod is fixedly arranged on the magnetic rod linear motion mechanism, the magnetic rod can be inserted into the magnetic sleeve, and the magnetic rod linear motion mechanism drives the magnetic rod to move up and down relative to the magnetic sleeve; the magnetic rod is provided with a plurality of rod bodies along the width direction of the kit, and the magnetic sleeves and the rod bodies of the magnetic rod are in the same number and are arranged in one-to-one correspondence.
Furthermore, the magnetic bar linear motion mechanism and the magnetic sleeve are relatively fixedly arranged, and the magnetic bar linear motion mechanism and the magnetic sleeve move up and down synchronously relative to the ball screw linear module.
Still further, the ball screw linear module comprises a vertical frame arranged above the kit, a ball screw linear module motor is arranged above the vertical frame, a ball screw mechanism is arranged on the vertical frame, the magnetic rod linear motion mechanism and the magnetic sleeve are arranged on a sliding seat of the ball screw mechanism, and the ball screw linear module motor rotates to drive the magnetic rod linear motion mechanism and the magnetic sleeve on the sliding seat to move up and down synchronously along the height direction of the vertical frame; the magnetic rod linear motion mechanism comprises a sub-sliding assembly arranged above the magnetic sleeve, the magnetic rod is arranged on a sub-sliding block of the sub-sliding assembly, and a linear motor arranged above the magnetic rod linear motion mechanism drives the sub-sliding block to move up and down relative to the magnetic sleeve.
Still further, the sub-sliding assembly comprises an upper connecting base block which is arranged in parallel relative to the reagent kit, the sub-sliding block is fixedly arranged on the outer side of the lower part of the upper connecting base block, the sub-sliding block and the upper connecting base block are arranged in parallel, a plurality of magnetic rods are arranged in parallel along the block length direction of the sub-sliding block, the upper ends of the magnetic rods are fixedly connected with the sub-sliding block, and the lower ends of the magnetic rods are inserted into the magnetic sleeve.
Still further, the sliding seat on be located sub-slider under and set up down and connect the base block, vertically run through on the lower connection base block and be provided with the bar hole, the magnetic sleeve set up in the below in bar hole, the bar magnet pass the bar hole and insert and arrange in the magnetic sleeve in.
Still further, the linear motor is a screw motor.
Still further, a set of nucleic acid extraction devices are arranged at equal intervals in the width direction of the kit.
The utility model has the technical effects that: the magnetic rods and the magnetic sleeves can synchronously move and can relatively move. The structure is ingenious like this, and the subassembly mutually noninterfere stroke, and the action is convenient, and is smooth and effective.
Drawings
FIG. 1 is a three-dimensional structure diagram of the present invention assembled on a magnetic bead method liquid separation extractor;
FIG. 2 is a perspective view of the present invention;
FIG. 3 is a perspective view of another aspect of the present invention;
FIG. 4 is a perspective view of one perspective of a kit to which the present invention is applied;
fig. 5 is a perspective view showing one view of another set of reagent cartridges to which the present invention is applied.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1, the liquid separating and extracting instrument using the magnetic bead method of the present invention is assembled, and includes an automatic liquid adding device 100, and automatic liquid adding of reagents in a plurality of regions can be simultaneously performed by the automatic liquid adding device 100; a nucleic acid extraction device 200 for performing nucleic acid extraction by the nucleic acid extraction device 200; the kit conveying device 300 is matched with the nucleic acid extracting device 200 through the kit conveying device 300 to perform accurate movement of each hole position, so that the nucleic acid extracting device 200 can work accurately; heating device 400 through heating device 400 to reagent needs accurate temperature control in the course of the work, improves the result detection accuracy who draws reagent.
The empty reagent box is placed on the reagent box clamping seat and is directly conveyed to the position below the automatic liquid adding device 100 under the control of the motor, the liquid adding needle moves downwards to be inserted into the reagent box, the corresponding reagent is automatically added into the reagent box by the liquid adding pump, the position of the reagent box below the liquid adding needle can be changed by continuously executing the motor of the reagent box conveying device, and therefore different reagents can be added into the reagent box to prepare for nucleic acid extraction in the next step. After the liquid in the kit is filled, the kit with the added reagent is moved to the lower part of the automatic extraction module 200 by the kit transportation device, the process of uniformly mixing the magnetic rod 205 and the magnetic sleeve 206 in the kit and transferring the magnetic beads is controlled according to the flow specified by the reagent specification, and the kit is automatically output after the nucleic acid extraction process is finished and is taken out for subsequent detection.
Specifically, the liquid separation extractor adopting the magnetic bead method comprises an automatic liquid adding device 100, a nucleic acid extracting device 200 and a kit conveying device 300, wherein the automatic liquid adding device 100 and the nucleic acid extracting device 200 are respectively arranged above the kit conveying device 300;
the automatic liquid adding device 100 comprises a liquid adding needle arranged above a reagent plate of the reagent box conveying device 300, the liquid adding needle is communicated with the output end of a liquid adding pump, the input end of the liquid adding pump is connected with a liquid suction tube, and the liquid adding needle can move in the upper, lower, left and right directions relative to the reagent box conveying device 300;
the nucleic acid extraction device 200 comprises a magnetic rod linear motion mechanism 204, wherein the magnetic rod linear motion mechanism 204 is arranged on a ball screw linear module, a magnetic sleeve 206 is arranged below the magnetic rod linear motion mechanism 204 on the ball screw linear module, the magnetic rod linear motion mechanism 204 and the magnetic sleeve 206 can move up and down relative to the ball screw linear module, a magnetic rod 205 is fixedly arranged on the magnetic rod linear motion mechanism 204, the magnetic rod 205 can be inserted into the magnetic sleeve 206, and the magnetic rod linear motion mechanism 204 drives the magnetic rod 205 to move up and down relative to the magnetic sleeve 206;
the reagent box conveying device 300 comprises a supporting platform, the automatic liquid adding device 100 and the nucleic acid extracting device 200 are both arranged on the supporting platform, a reagent plate is arranged on the supporting platform, a reagent box clamping seat is arranged on the reagent plate, a reagent box is arranged on the reagent box clamping seat, and the reagent plate can freely move between the automatic liquid adding device 100 and the nucleic acid extracting device 200;
the liquid adding needle and nucleic acid extracting device 200 is provided with a plurality of groups, and a corresponding reagent plate is arranged below each group of liquid adding needle and nucleic acid extracting device 200.
Further, every group reagent board department of kit conveyer 300 correspond and set up heating device 400, heating device 400 be located the below of kit, heating device 400 including set firmly the heating base on the supporting platform of kit conveyer 300, set up the heating piece on the heating base, the heating piece is inside including heating the original paper, heating lead screw motor drives heating piece, heating base can move from top to bottom.
Assembling the magnetic bead method liquid separation extractor of the utility model:
1. extracting reagent is automatically added before and during the extraction process of nucleic acid, so that the problem of manually adding reagent in advance or during the process is avoided.
2. The instrument is sized using a high throughput nucleic acid extraction design.
3. Distinguish a plurality of reagent and draw the workspace, every reagent draws the workspace mutually independent, and mutual noninterference solves the interconversion of little flux and big flux extraction, can also solve simultaneously that there is the sample to advance at any time, can carry out extraction work at any time the condition.
Further specifically, the nucleic acid extraction device of the magnetic bead method liquid separation extractor comprises a magnetic rod linear motion mechanism 204, wherein the magnetic rod linear motion mechanism 204 is arranged on a ball screw linear module 202, a magnetic sleeve 206 is arranged below the magnetic rod linear motion mechanism 204 on the ball screw linear module 202, the magnetic rod linear motion mechanism 204 and the magnetic sleeve 206 can move up and down relative to the ball screw linear module 202, a magnetic rod 205 is fixedly arranged on the magnetic rod linear motion mechanism 204, the magnetic rod 205 can be inserted into the magnetic sleeve 206, and the magnetic rod linear motion mechanism 204 drives the magnetic rod 205 to move up and down relative to the magnetic sleeve 206; the magnetic rods 205 are provided with a plurality of rod bodies along the width direction of the kit, and the magnetic sleeves 206 are arranged in a one-to-one correspondence manner and the number of the rod bodies of the magnetic rods 205 is consistent.
Further, the magnetic rod linear motion mechanism 204 and the magnetic sleeve 206 are relatively fixedly arranged, and the magnetic rod linear motion mechanism 204 and the magnetic sleeve 206 move up and down synchronously relative to the ball screw linear module 202.
Still further, the ball screw linear module 202 comprises a vertical frame arranged above the kit, a ball screw linear module motor 201 is arranged above the vertical frame, a ball screw mechanism is arranged on the vertical frame, the magnetic rod linear motion mechanism 204 and the magnetic sleeve 206 are arranged on a sliding seat of the ball screw mechanism, and the rotation of the ball screw linear module motor 201 drives the magnetic rod linear motion mechanism 204 and the magnetic sleeve 206 on the sliding seat to move up and down synchronously along the height direction of the vertical frame; the magnetic rod linear motion mechanism 204 comprises a sub-sliding assembly arranged above the magnetic sleeve 206, the magnetic rod 205 is arranged on a sub-sliding block of the sub-sliding assembly, and the linear motor 203 arranged above the magnetic rod linear motion mechanism 204 drives the sub-sliding block to move up and down relative to the magnetic sleeve 206.
Still further, the sub-sliding assembly comprises an upper connection base block arranged in parallel relative to the reagent kit, the sub-sliding block is fixedly arranged on the outer side of the lower portion of the upper connection base block, the sub-sliding block and the upper connection base block are arranged in parallel, a plurality of magnetic rods 205 are arranged in parallel along the block length direction of the sub-sliding block, the upper ends of the magnetic rods 205 are fixedly connected with the sub-sliding block, and the lower ends of the magnetic rods 205 are inserted into the magnetic sleeves 206.
Still further, the sliding seat on be located sub-slider under and set up down and connect the base block, vertically run through on the lower connection base block and be provided with the bar hole, magnetic sleeve 206 set up in the below in bar hole, bar magnet 205 pass the bar hole and insert and arrange in magnetic sleeve 206.
Still further, the linear motor 203 is a screw motor.
The upper and lower parts of the sliding seat are provided with an upper connecting base block and a lower connecting base block, so that when the linear motor 203 does not work, the plurality of magnetic rods 205 fixed relative to the upper connecting base block and the magnetic sleeve 206 fixed relative to the lower connecting base block are driven by the ball screw linear module motor 201 to drive the ball screw mechanism to move so as to drive the plurality of magnetic rods 205 and the magnetic sleeve 206 on the sliding seat to synchronously move; when the linear motor 203 works, because the linear motor 203 is also a lead screw motor, the linear motor 203 drives a plurality of magnetic rods 205 fixed on the sub-sliding block of the upper connecting base block to move up and down, and the magnetic sleeve 206 is relatively fixedly arranged on the lower connecting base block. The structure is ingenious, the two groups of screw rod assemblies do not interfere with the stroke, and the action is convenient, smooth and effective.
Still further, 3 sets of nucleic acid extracting devices 200 are provided at equal intervals in the width direction of the kit.
Still further, the supporting platform of the reagent box transporting device 300 is provided with 3 groups of nucleic acid extracting devices 200 at equal intervals along the width direction of the reagent box transporting device 300, 3 groups of reagent plates are correspondingly arranged below the 3 groups of nucleic acid extracting devices 200, liquid adding needles are arranged above the second synchronous belts of the 3 groups of reagent plates, and 3 groups of heating devices 400 are respectively arranged at the other ends above the second synchronous belts of the 3 groups of reagent plates.
The nucleic acid isolation apparatus 200 thus configured is widely applicable.
Still further, kit conveyer 300 still include the cotton stick guide holder that absorbs water, the cotton stick guide holder that absorbs water be located heating device 400's avoidance position, the cotton stick guide holder that absorbs water arrange along the length direction of kit conveyer 300's kit, set up the cotton stick that absorbs water on the cotton stick guide holder that absorbs water, the liquid feeding needle can move to cotton stick guide holder department that absorbs water downwards.
The nucleic acid extraction apparatus 200 comprises the following specific mechanisms: the ball screw linear module motor 201 controls the rotation of the ball screw mechanism to drive the magnetic rod linear motion mechanism 204 to move up and down, and the magnetic sleeve 206 is fixed below the magnetic rod linear motion mechanism 204 (i.e. the magnetic rod linear motion mechanism 204 and the magnetic sleeve 206 are fixed on the sliding seat of the ball screw mechanism). Thus, the magnetic rod linear motion mechanism 204 moves up and down and drives the magnetic sleeve 206 to move up and down linearly. The linear motor 203 above the magnetic rod linear motion mechanism 204 is a screw motor, the linear motor 203 rotates to drive the magnetic rod linear motion mechanism 204 to move up and down, and the magnetic rod 205 is fixed on the magnetic rod linear motion mechanism 204, so that the magnetic rod 205 can move relatively (up and down) relative to the magnetic sleeve 206, and the magnetic rod 205 is conveniently inserted into or lifted out of the magnetic sleeve 206. As shown in FIG. 4, the nucleic acid isolation apparatus 200 is mainly composed of a ball screw linear module (including a ball screw linear module motor 201) and a magnetic rod linear motion mechanism 204, wherein the ball screw linear module motor 201 drives the magnetic rod linear motion mechanism 204 to move up and down, and the magnetic sleeve 206 is fixed below the magnetic rod linear motion mechanism 204, so that when the ball screw moves up and down, the ball screw linear motion mechanism 204 is driven to move up and down and the magnetic sleeve 206 is driven to move up and down synchronously. The magnetic rod 205 in the magnetic rod linear motion mechanism 204 can independently control the lifting motion by the magnetic rod linear motion mechanism 204, so that the linear motor 203 can control the magnetic rod 205 and the magnetic sleeve 206 to simultaneously lift and move and the magnetic rod 205 and the magnetic sleeve 206 to relatively (up and down) move. Just so for the effect of magnetic sleeve 205 in the nucleic acid extraction process, namely in the deep hole board (set up on the reagent board of kit conveyer 300, can be the same board with the reagent board in this scheme, of course, can also be set up in different boards on the reagent board as required) the high-speed up-and-down motion plays the effect of stirring liquid in the deep hole board, and then more efficient carries out the mixing. Specifically, when the magnetic rod 205 is lowered and inserted into the magnetic sleeve 206, the bottom of the magnetic sleeve 206 can generate a strong magnetic field due to the magnetic rod 205 at the bottom of the magnetic sleeve 206, therefore, magnetic particles suspended in the reagent box can be conveniently adsorbed, the completely adsorbed magnetic particles are lifted out of the upper part of the reagent box by the ball screw linear module motor 201 and then are conveniently transferred into the next hole position of the reagent box 301 by matching with the motion of the reagent box conveying device 300, and then the magnetic rod 205 is controlled to be lifted out of the magnetic sleeve 206 by the lifting of the magnetic rod linear motion mechanism 204, thus, the magnetism at the bottom of the magnetic sleeve 206 disappears, the ball screw linear module motor 201 controls the up-and-down motion of the magnetic sleeve 206 to break up the uniformly mixed magnetic beads, and carrying out uniform mixing operation at the next kit hole position, thereby achieving a series of steps of magnetic bead adsorption, transportation, scattering and uniform mixing, and completing the work flow of nucleic acid extraction.
In summary, the beneficial effects of the utility model include: comprises a plurality of (3 in the example) free extraction stations, and a plurality of (3 in the example) nucleic acid extraction apparatuses 200, a plurality of (3 in the example) reagent cartridge transport apparatuses 300, and a plurality of (3 in the example) heating apparatuses 400. This facilitates the extraction of nucleic acids from a plurality of (3 in the examples) regions, respectively, without directly interfering with each other. Thus, when the sample volume is small, one group of extraction can be carried out, when the sample volume is large, three groups of extraction can be carried out to realize the requirement that the small flux and the large flux simultaneously meet, and in addition, the other two groups of nucleic acid extraction can be inserted into one group of independent extraction modules (three groups are provided in the embodiment) at any time when one group of nucleic acid extraction modules carries out extraction, so that the requirement that the extraction work can be carried out at any time is realized.
It will be evident to those skilled in the art that the utility model is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof.
Claims (7)
1. The utility model provides a magnetic bead method divides liquid extraction appearance's nucleic acid extraction element which characterized in that: the magnetic rod linear motion mechanism (204) is arranged on a ball screw linear module (202), a magnetic sleeve (206) is arranged below the magnetic rod linear motion mechanism (204) on the ball screw linear module (202), the magnetic rod linear motion mechanism (204) and the magnetic sleeve (206) can move up and down relative to the ball screw linear module (202), a magnetic rod (205) is fixedly arranged on the magnetic rod linear motion mechanism (204), the magnetic rod (205) can be inserted into the magnetic sleeve (206), and the magnetic rod linear motion mechanism (204) drives the magnetic rod (205) to move up and down relative to the magnetic sleeve (206); the magnetic rods (205) are provided with a plurality of rod bodies along the width direction of the kit, and the magnetic sleeves (206) are in one-to-one correspondence with the rod bodies of the magnetic rods (205) in number.
2. The nucleic acid extraction device of the magnetic bead method separation extractor according to claim 1, characterized in that: the magnetic rod linear motion mechanism (204) and the magnetic sleeve (206) are relatively fixedly arranged, and the magnetic rod linear motion mechanism (204) and the magnetic sleeve (206) move up and down synchronously relative to the ball screw linear module (202).
3. The nucleic acid extraction device of the magnetic bead method separation extractor according to claim 1 or 2, characterized in that: the ball screw linear module (202) comprises a vertical frame arranged above the kit, a ball screw linear module motor (201) is arranged above the vertical frame, a ball screw mechanism is arranged on the vertical frame, the magnetic rod linear motion mechanism (204) and the magnetic sleeve (206) are arranged on a sliding seat of the ball screw mechanism, and the rotation of the ball screw linear module motor (201) drives the magnetic rod linear motion mechanism (204) and the magnetic sleeve (206) on the sliding seat to move up and down synchronously along the height direction of the vertical frame; the magnetic rod linear motion mechanism (204) comprises a sub-sliding assembly arranged above the magnetic sleeve (206), the magnetic rod (205) is arranged on a sub-sliding block of the sub-sliding assembly, and a linear motor (203) above the magnetic rod linear motion mechanism (204) drives the sub-sliding block to move up and down relative to the magnetic sleeve (206).
4. The nucleic acid extraction device of the magnetic bead method separation extractor according to claim 3, characterized in that: the sub-sliding assembly comprises an upper connecting base block which is arranged in parallel relative to the kit, the sub-sliding block is fixedly arranged on the outer side of the lower part of the upper connecting base block, the sub-sliding block and the upper connecting base block are arranged in parallel, a plurality of magnetic rods (205) are arranged in parallel along the block length direction of the sub-sliding block, the upper ends of the magnetic rods (205) are fixedly connected with the sub-sliding block, and the lower ends of the magnetic rods (205) are inserted into the magnetic sleeves (206).
5. The nucleic acid extraction device of the magnetic bead method separation extractor according to claim 4, wherein: the slider on be located the sub-slider under set up and connect the base block, connect the vertical strip hole that runs through on the base block down, magnetic sleeve (206) set up in the below in strip hole, magnetic rod (205) pass the strip hole and insert and arrange in magnetic sleeve (206).
6. The nucleic acid extraction device of the magnetic bead method separation extractor according to claim 3, characterized in that: the linear motor (203) is a screw motor.
7. The nucleic acid extraction device of the magnetic bead method separation extractor according to claim 1 or 2, characterized in that: 3 sets of nucleic acid extraction devices (200) are arranged at equal intervals in the width direction of the kit.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202121950799.2U CN216192370U (en) | 2021-08-19 | 2021-08-19 | Nucleic acid extraction device of magnetic bead method liquid separation extraction instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121950799.2U CN216192370U (en) | 2021-08-19 | 2021-08-19 | Nucleic acid extraction device of magnetic bead method liquid separation extraction instrument |
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| CN216192370U true CN216192370U (en) | 2022-04-05 |
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| CN202121950799.2U Active CN216192370U (en) | 2021-08-19 | 2021-08-19 | Nucleic acid extraction device of magnetic bead method liquid separation extraction instrument |
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- 2021-08-19 CN CN202121950799.2U patent/CN216192370U/en active Active
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