CN215265253U - Gastric antrum simulation assembly and gastric motility simulation device - Google Patents

Abstract

The utility model discloses a gastric antrum simulation subassembly and stomach dynamic simulation device. The antrum gastric simulation subassembly includes urceolus and grinding portion, grinding portion activity is located the inside of urceolus, be provided with the grinding hole in the grinding portion, grinding portion follows the extending direction of urceolus for urceolus reciprocating motion is possible, so that the grinding hole passes and is located the inside material of urceolus. In the process that grinding portion moved for the urceolus, the grinding hole can pass the material, and the edge in grinding hole can grind the shearing to the medicine to through the reciprocating motion of grinding portion, make the high-efficient mixture of material. This antrum of stomach simulation subassembly can provide the environment of high shear force and high-efficient mixture for the material to can simulate the comparatively violent wriggling process of antrum of stomach, thereby perfect the simulation to whole stomach, improved the accuracy of experimental result.

Description

Gastric antrum simulation assembly and gastric motility simulation device

Technical Field

The utility model relates to a human gastrointestinal tract drug absorption experiment field, in particular to gastric antrum simulation subassembly and stomach dynamic simulation device.

Background

Oral administration is the most common, convenient and safe route of administration, and oral drugs are first absorbed from the gastrointestinal tract to take effect, which is very complicated. Factors influencing the oral absorption of the medicine mainly include pharmaceutical physicochemical factors, such as crystal form, particle size, solubility, permeability, preparation size and shape, preparation process and the like; and gastrointestinal physiological factors such as changes in the pH of the gastrointestinal tract, gastric emptying, food effects, intestinal metabolic enzymes, gastrointestinal kinetics, and the like.

The human stomach is divided into two major regions, the proximal (upper) end being a milder, non-uniform mixing region and the distal (lower) end being a mixing region of the stomach with high shear forces, i.e., the antrum. The peristaltic contraction of the stomach is caused by the tonic contraction of the upper surface of the stomach and continues to the pyloric valve, the peristaltic wave moves towards the pylorus in a continuous manner, the contraction is performed 2-3 times at any time, the contraction frequency is about 3 times/min, the propagation speed is about 2.5mm/s, and the contraction is gradually accelerated from the proximal end to the distal end. Gastric emptying refers to the process by which food is expelled from the stomach into the duodenum, the gastric emptying being dependent on the pressure difference across the pylorus (direct kinetics), the rate of gastric emptying also being related to the nature and chemical composition of the food, the liquid and small particles flowing from the stomach through the pylorus into the duodenum, while the larger particles flow back into the stomach, and this repeated propelling, grinding, mixing and back-flow reduces the size of the food particles, which are converted into an emulsion-like digest, called "chyme", which is expelled into the duodenum.

The human stomach is a very complex dynamic system, especially after eating, and therefore the usual, simple, static in vitro evaluation techniques or models are not sufficient to simulate the release and absorption of drugs in a solid oral formulation over a period of hours.

With existing devices for simulating the intestines and stomach, which generally comprise a stomach simulation chamber and a stirrer extending into the stomach simulation chamber, the simulation of the digestive process of the stomach is achieved by the rotation of the stirrer. However, the above device is only directed to a mild digestive process of a stomach body, and it is difficult to simulate the peristalsis of the whole stomach, especially a digestive process having a high shear force in a antrum portion of the stomach, resulting in a large influence on the accuracy of the simulation result.

SUMMERY OF THE UTILITY MODEL

The to-be-solved technical problem of the utility model is that the device that is used for simulating stomach developments among the overcoming prior art is difficult to simulate the stomach sinus part, leads to influencing the defect of experimental result accuracy, provides a stomach sinus simulation subassembly and stomach dynamic simulation device.

The utility model discloses an above-mentioned technical problem is solved through following technical scheme:

the utility model provides a gastric antrum simulation subassembly for stomach dynamic simulation device, its characterized in that, gastric antrum simulation subassembly includes urceolus and grinding portion, grinding portion's activity is located the inside of urceolus, be provided with the grinding hole in the grinding portion, the grinding portion is followed the extending direction of urceolus for but urceolus reciprocating motion, so that the grinding hole passes and is located the inside material of urceolus.

In this scheme, the capacity of human stomach sinus part can be simulated to the volume in holding chamber, and the material is located the holding intracavity, grinds the in-process of portion for the urceolus motion at the grinding, and the grinding hole can pass the material, and the edge in grinding the hole can grind the shearing to the medicine to reciprocating motion through grinding the portion makes the high-efficient mixture of material. This antrum of stomach simulation subassembly can provide the environment of high shear force and high-efficient mixture for the material to can simulate the comparatively violent wriggling process of antrum of stomach, thereby perfect the simulation to whole stomach, improved the accuracy of experimental result.

Preferably, the grinding part is an inner cylinder, the grinding hole is located at the top of the inner cylinder, the outer cylinder is sleeved outside the inner cylinder, and the outer side wall of the inner cylinder is tightly attached to the inner side wall of the outer cylinder.

In the scheme, the grinding part is arranged in a cylindrical shape, so that the grinding part can conveniently move along the outer cylinder, and the grinding hole is prevented from generating offset in the moving process; the inner cylinder is closely matched with the outer cylinder, so that the materials are only positioned in the inner cylinder and the outer cylinder on the upper side of the inner cylinder, the materials are prevented from falling between the outer side wall of the inner cylinder and the inner side wall of the outer cylinder, and all the materials can be cut and mixed.

Preferably, the inner tube includes barrel and bush, the bush can dismantle connect in the top of barrel, the middle part of bush has been seted up the grinding hole, the lateral wall of bush with the inside wall of urceolus, the lateral wall of barrel with the inside wall of urceolus closely laminates respectively.

In this scheme, the bush is connected for dismantling with the barrel, and operating personnel can independently change the bush that has the grinding hole in different apertures according to actual need (for example, diameter, the size of medicine) to improve the suitability of this stomach sinus simulation subassembly, make things convenient for the automatic unloading of tablet and the material of different specifications.

Preferably, the gastric sinus simulation subassembly still includes the piston, the piston is located the inside of inner tube, the piston include the piston rod with connect in the stopper of piston rod, the periphery wall of stopper with the inside wall of inner tube is closely laminated.

In this scheme, the piston can be used to inject the volume of holding chamber, and the back is fixed to the piston position promptly, and the material is located in the space of injecing between piston and the inner tube and in the urceolus of inner tube upside.

Preferably, the antrum simulation assembly has a first motion state in which the outer cylinder and the piston are relatively stationary and the inner cylinder undergoes the reciprocating motion relative to the outer cylinder and the piston;

the inner barrel is provided with a first limit position and a second limit position, and when the inner barrel is located at the first limit position, the top surface of the inner barrel is close to or abutted against the top of the outer barrel; when the inner cylinder is positioned at the second limit position, the lower end surface of the grinding hole of the inner cylinder is close to the top surface of the piston.

In the scheme, in the first motion state, the simulation of the peristalsis of the gastric antrum part is realized through the reciprocating motion of the inner cylinder.

Preferably, the antrum simulation assembly has a second motion state in which the piston moves upwardly to push the material out of the outer cylinder.

In this scheme, under the second motion state, through piston upward movement, promote the material rebound and discharge urceolus to the process of gastric antrum evacuation has been simulated, the operating personnel of being convenient for observe the grinding state of medicine in the mixed materials.

Preferably, the antrum gastric simulator assembly is provided with a transmission mechanism and a driving mechanism, the transmission mechanism is connected to the inner cylinder, and the driving mechanism drives the transmission mechanism to drive the inner cylinder to reciprocate;

the antrum gastric simulation assembly further comprises a control mechanism electrically connected to the drive mechanism and used for controlling the opening and closing of the drive mechanism.

Preferably, the transmission mechanism comprises a guide part, a sliding part and a connecting bracket, the guide part extends along the movement direction of the inner cylinder, the sliding part can slide on the guide part, and two ends of the connecting bracket are respectively connected to the inner cylinder and the sliding part;

the driving mechanism comprises a stepping motor, and the output end of the stepping motor is connected to the sliding part.

In this scheme, the guide part is used for restricting the reciprocating motion of sliding part along the preset direction of motion of inner tube, and step motor is used for exporting linear displacement to sliding part, and sliding part passes through linking bridge and drives inner tube reciprocating motion.

Preferably, the antrum gastric simulator assembly further comprises a limit sensor, the limit sensor is arranged on the piston and/or the inner cylinder and used for detecting the distance between the lower end surface of the inner cylinder at the grinding hole and the top surface of the piston, and the limit sensor is in signal connection with the control mechanism.

In this scheme, through setting up spacing sensor, can detect the lower terminal surface of the department of grinding hole of inner tube with the distance between the top surface of piston, when this distance is less than predetermined minimum interval, spacing sensor sends the signal to control mechanism, and control mechanism received signal controls inner tube stop motion or reverse motion to prevent mechanical grinding medicine.

Preferably, the movement speed of the inner cylinder is adjustable within the range of 5mm/s to 50 mm/s;

and/or a preset minimum distance is formed between the lower end surface of the grinding hole of the inner cylinder and the top surface of the piston, and the minimum distance is 20 mm;

and/or the inner cylinder is detachably connected with the outer cylinder;

and/or the diameter of the grinding holes ranges between 8mm and 16 mm;

and/or the antrum simulation assembly further comprises a first sealing element for sealing between the outer wall surface of the piston and the inner wall surface of the inner barrel;

and/or the antrum simulation assembly further comprises a second sealing element for sealing between the outer wall surface of the inner cylinder and the inner wall surface of the outer cylinder.

In the scheme, the movement speed of the inner cylinder is adjustable, and different grinding forces or shearing forces can be simulated according to requirements; the minimum distance is 20mm, and the distance can avoid excessive grinding of materials; the inner cylinder and the outer cylinder are detachably connected, so that the inner cylinder and the outer cylinder are convenient to install and maintain; the diameter of the grinding hole is between 8mm and 16mm, and the grinding hole is suitable for medicines with different sizes; the first sealing element and the second sealing element are used for sealing between the piston and the inner cylinder and between the inner cylinder and the outer cylinder.

A gastric motility simulator device, characterized in that it comprises the antrum simulator assembly described above.

In this scheme, adopt above-mentioned antrum of stomach simulation subassembly in stomach dynamic analogue means for correspondingly, make stomach dynamic analogue means can simulate the comparatively violent wriggling process of antrum of stomach, thereby perfect the simulation to whole stomach, improved the accuracy of experimental result.

Preferably, stomach dynamic simulation device still includes the stirring subassembly, the stirring subassembly includes agitator and hopper, the output of agitator stretches into the inside of hopper, the hopper has the discharge gate, the discharge gate be used for to stomach sinus simulation subassembly transported substance material.

In the scheme, the hopper is used for containing initial materials, the purpose of mixing and dissolving media is achieved through the stirring of the output end of the stirrer, and the hopper is used for simulating the process of mixing food through stomach peristalsis at the upper part of the gastric antrum; the mixed material enters the antrum simulation assembly through the discharge hole.

Preferably, the gastric antrum simulation subassembly still includes the three-way valve, the first opening of three-way valve communicate in the hopper, the second opening of three-way valve communicate in the gastric antrum simulation subassembly, the third opening of three-way valve communicates in the take-up (stock) pan, the take-up (stock) pan is arranged in placing the follow discharged material in the gastric antrum simulation subassembly.

In the scheme, a passage between a first opening and a second opening of a three-way valve is used for allowing materials in a feeding hopper to enter a gastric antrum simulation assembly; and a passage between the second opening and the third opening is used for discharging the materials in the gastric antrum simulation assembly to the receiving tray. The three-way valve is adopted, so that the structure is simple, and the operation and the installation are convenient.

Preferably, the gastric motility simulator further comprises an electric heating and heat preservation system, the electric heating and heat preservation system comprises a heater and a temperature control system, the heater is annularly arranged outside the outer cylinder, and the temperature control system controls the power of the heater according to the temperature in the outer cylinder;

and/or the gastric motility simulation device also comprises a safety protection system, wherein the safety protection system comprises a leakage protector and a buzzer which are connected with the electric heating and heat preservation system;

and/or, the stomach dynamic simulation device still includes PLC control system, PLC control system's output electricity connect in the actuating mechanism of stomach sinus simulation subassembly, electrical heating heat preservation system with the safety protection system.

In the scheme, the heater is used for heating materials or the inside of the outer barrel, and when the temperature reaches a set temperature, the temperature control system controls the heating power of the heater according to the temperature return difference; the safety protection system is used for providing overload and short-circuit protection functions when the equipment has electric leakage faults, and the buzzer is mainly based on the piezoelectric effect of piezoelectric ceramics to drive the metal sheet to vibrate and sound; the PLC control system is used for controlling the overall operation, executing instructions facing users, such as logic operation, sequence control, timing and the like, and controlling an operation program through digital input and output.

Preferably, the gastric motility simulator further comprises an outer shell, the antrum simulation assembly is located inside the outer shell, and the stirring assembly is located above the outer shell;

and/or the gastric motility simulating device further comprises a rolling piece, the rolling piece is arranged at the bottom of an outer shell, the gastric antrum simulating assembly is positioned in the outer shell, and the stirring assembly is positioned above the outer shell;

and/or the gastric motility simulator also comprises a human-computer interaction interface which is electrically connected with the input end and the output end of the PLC control system;

and/or, the stomach dynamic simulation device still includes the baffle, the baffle connect in the top surface and the bottom surface of shell body, PLC control system with the stomach sinus simulation subassembly is located respectively the both sides of baffle.

In the scheme, the gastric antrum simulation assembly is positioned inside the outer shell, and the outer shell plays a role in protecting the gastric antrum simulation assembly; the stirring assembly is positioned above the outer shell, so that an operator can conveniently pour materials into the stirring assembly and observe the mixing condition of the materials; the rolling piece is arranged at the bottom of the box body to facilitate movement; an operator can input instructions such as volume parameters, running speed and the like to the PLC control system through a human-computer interaction interface, and the human-computer interaction interface can display various information such as real-time positions, running speeds and the like of the inner cylinder and the piston rod through graphs; the baffle is used for separating the antrum simulation assembly and the PLC control system.

On the basis of the common knowledge in the field, the above preferred conditions can be combined at will to obtain the preferred embodiments of the present invention.

The utility model discloses an actively advance the effect and lie in:

to this stomach sinus simulation subassembly, the human stomach sinus part of simulation of stomach sinus simulation subassembly, the material is located the urceolus, and at the in-process of grinding portion for the urceolus motion, the grinding hole can pass the material, and the edge in grinding hole can grind the shearing to the medicine to reciprocating motion through grinding portion makes the high-efficient mixture of material. This antrum of stomach simulation subassembly can provide the environment of high shear force and high-efficient mixture for the material to can simulate the comparatively violent wriggling process of antrum of stomach, thereby perfect the simulation to whole stomach, improved the accuracy of experimental result. Accordingly, the gastric motility simulating device comprising the antrum simulating assembly has the advantages of simulating the peristalsis process of the antrum and perfectly simulating the whole stomach.

Drawings

Fig. 1 is a cross-sectional view of a gastric motility simulator according to a preferred embodiment of the invention, with the piston and inner barrel in initial positions.

Figure 2 is an enlarged partial view of a antrum simulation assembly according to a preferred embodiment of the present invention, wherein the antrum simulation assembly is in a first motion state.

Fig. 3 is a front view of the gastric motility simulator according to the preferred embodiment of the present invention, wherein the piston and the inner cylinder are in the initial position.

Description of reference numerals:

antrum gastric simulator assembly 1

Outer cylinder 11

Accommodating chamber 10

Inner barrel 12

Grinding hole 121

Barrel 122

Bushing 123

Piston 13

Piston rod 131

Blocking part 132

First transmission mechanism 14

First drive mechanism 15

First stepping motor 151

First guide part 141

First sliding part 142

First connecting bracket 143

Second transmission mechanism 16

Second drive mechanism 17

Second stepping motor 171

Second guide 161

Second sliding part 162

Second connecting bracket 163

First seal 18

Second seal 19

Gastric motility simulator 100

Stirring assembly 2

Stirrer 21

Hopper 22

Paddle shaft 222

Stirring motor 23

Three-way valve 24

Outer casing 25

Touch screen 26

Solenoid valve 27

Operating button 28

Detailed Description

The present invention is further illustrated by way of the following examples, which are not intended to limit the scope of the invention.

The present embodiment provides a antrum simulator assembly 1 for a gastric motility simulator. As shown in fig. 1 to 3, the antrum gastric simulator assembly 1 includes an outer tube 11 and a grinding part, wherein an accommodating cavity 10 for accommodating materials is formed inside the outer tube 11, the grinding part is movably arranged inside the accommodating cavity 10 inside the outer tube 11, a grinding hole 121 is arranged on the grinding part, and the grinding part can reciprocate relative to the outer tube 11 along the extending direction of the outer tube 11 so that the grinding hole 121 passes through the materials.

Human stomach sinus part can be simulated to stomach sinus simulation subassembly 1, and the capacity of human stomach sinus part can be simulated to the volume of holding chamber 10, and the material is located holding chamber 10, and at the in-process of grinding portion for the 11 motion of urceolus, grinding hole 121 can pass the material, and the edge of grinding hole 121 can grind the shearing to the medicine, through the reciprocating motion of grinding portion for the high-efficient mixture of material. This antrum of stomach simulation subassembly 1 can provide the environment of high shear force and high-efficient mixture for the material to can simulate the comparatively violent wriggling process of antrum of stomach, thereby perfect the simulation to whole stomach, improved the accuracy of experimental result.

In the present embodiment, the term "the grinding part is reciprocally movable with respect to the outer cylinder 11" means that the outer cylinder 11 is kept stationary and the grinding part is reciprocally moved, and means that the grinding part is kept stationary and the outer cylinder 11 is reciprocally moved, as long as relative movement between the grinding part and the outer cylinder 11 can be achieved. The material can be understood as a test substance such as a drug, food or a mixture thereof.

In a preferred embodiment, the polishing portion is an inner cylinder 12, the polishing holes 121 are located at the top of the inner cylinder 12, the outer cylinder 11 is sleeved outside the inner cylinder 12, and the outer sidewall of the inner cylinder 12 is tightly attached to the inner sidewall of the outer cylinder 11. The grinding part is cylindrical, so that the grinding part can move along the outer cylinder 11 conveniently, and the grinding hole 121 is prevented from being biased in the moving process; the inner barrel 12 is tightly matched with the outer barrel 11, so that the materials are only positioned in the inner barrel 12 and the outer barrel 11 on the upper side of the inner barrel 12, the materials are prevented from falling between the outer side wall of the inner barrel 12 and the inner side wall of the outer barrel 11, and all the materials can be cut and mixed.

The inner cylinder 12 comprises a cylinder 122 and a bushing 123, the bushing 123 is detachably connected to the top of the cylinder 122, a grinding hole 121 is formed in the middle of the bushing 123, and the outer side wall of the bushing 123 is tightly attached to the inner side wall of the outer cylinder 11, the outer side wall of the cylinder 122 is tightly attached to the inner side wall of the outer cylinder 11 respectively. Wherein, bush 123 is connected for dismantling with barrel 122, and operating personnel can independently change the bush 123 that has the grinding hole 121 in different apertures according to actual need (for example, diameter, the size of medicine) to improve this antrum gastric simulation subassembly 1's suitability, make things convenient for the automatic unloading of tablet or the material of different specifications.

In a preferred embodiment, the antrum simulator 1 further comprises a piston 13, the piston 13 is disposed inside the inner cylinder 12, the piston 13 comprises a piston rod 131 and a blocking portion 132 connected to the piston rod 131, and the outer peripheral wall of the blocking portion 132 is closely attached to the inner side wall of the inner cylinder 12. After the piston 13 is fixed, the material is located in the accommodating cavity 10, i.e. the space defined between the piston 13 and the inner cylinder 12 and the outer cylinder 11 on the upper side of the inner cylinder 12.

The antrum gastric simulation assembly 1 is provided with a first transmission mechanism 14 and a first driving mechanism 15, the first transmission mechanism 14 is connected to the inner cylinder 12, and the first driving mechanism 15 drives the first transmission mechanism 14 to drive the inner cylinder 12 to reciprocate; the antrum simulation assembly 1 further comprises a control mechanism electrically connected to the first drive mechanism 15 and configured to control the opening and closing of the first drive mechanism 15. It should be noted that, in the present embodiment, the first transmission mechanism 14 is connected to the inner cylinder 12, and in other alternative embodiments, the first transmission mechanism 14 may also be connected to the outer cylinder 11 and the piston 13, so that the inner cylinder 12 is kept stationary and the outer cylinder 11 and the piston 13 reciprocate relative to the inner cylinder 12.

As a preferred embodiment, the first transmission mechanism 14 includes a first guide portion 141, a first sliding portion 142 and a first connecting bracket 143, the first guide portion 141 extends along the moving direction of the inner cylinder 12, the first sliding portion 142 is slidable on the first guide portion 141, and both ends of the first connecting bracket 143 are connected to the inner cylinder 12 and the first sliding portion 142, respectively; the first driving mechanism 15 includes a first stepping motor 151, and an output end of the first stepping motor 151 is connected to the first sliding portion 142. The first guiding portion 141 is configured to limit the first sliding portion 142 to reciprocate along a preset movement direction of the inner cylinder 12, the first stepping motor 151 is configured to output linear displacement to the first sliding portion 142, and the first sliding portion 142 drives the inner cylinder 12 to reciprocate through the first connecting bracket 143.

In the preferred embodiment, the first transmission mechanism includes a first guide portion and a first slide portion, the first drive mechanism is connected to the first slide portion, and the first slide portion slides with respect to the first guide portion. In other alternative embodiments, the first transmission mechanism may also adopt other transmission modes, for example, the first transmission mechanism may also include a transmission belt, a driving wheel and a driven wheel which are matched with each other, the driving wheel is connected to the output end of the first driving mechanism, and the transmission belt drives the first connecting bracket to reciprocate so as to drive the inner cylinder to reciprocate.

In a preferred embodiment, the first guiding portion 141 is a ball sliding table, the first sliding portion 142 is a sliding block disposed on the ball sliding table, and the inner cylinder 12 is vertically disposed and the moving direction is a vertical direction.

Antrum simulation assembly 1 may have a first motion state that simulates the process of antral peristalsis. In the first state of motion, the outer cylinder 11 and the piston 13 are relatively stationary and the inner cylinder 12 reciprocates relative to the outer cylinder 11 and the piston 13. Wherein, the inner cylinder 12 has a first limit position and a second limit position, when the inner cylinder 12 is located at the first limit position, the top surface of the inner cylinder 12 is close to or abutted against the top of the outer cylinder 11; when the inner cylinder 12 is located at the second limit position, the lower end surface of the grinding hole of the inner cylinder 12 is close to the top surface of the piston 13. The simulation of the peristalsis of the gastric antrum part is realized through the reciprocating motion of the inner cylinder 12. When the inner drum 12 is in the first extreme position, the top surface of the inner drum 12 is close to but not in contact with the top of the outer drum 11, so that the arrangement can prevent the top surface of the inner drum and the top of the outer drum from scraping to generate debris and pollute materials. In the present embodiment, the outer cylinder 11 and the piston 13 may be kept stationary and the inner cylinder 12 may reciprocate, or the inner cylinder 12 may be kept stationary and the outer cylinder 11 and the piston 13 may reciprocate synchronously as long as relative movement between the inner cylinder 12 and the outer cylinder 11 and the piston 13 can be maintained.

The antrum simulation assembly 1 may also have a second state of motion that expels material from the receiving cavity 10. In the second movement state, the piston 13 moves upward to push the material out of the accommodation chamber 10. The piston 13 moves upwards to push the materials to move upwards and discharge the materials out of the accommodating cavity 10, so that the emptying process of the gastric antrum is simulated, and an operator can observe the grinding state of the medicines in the mixed materials conveniently. The second movement state can also be understood as a reset state, in which the piston 13 and the inner cylinder 12 are in the initial position after completion of the second movement state.

In this embodiment, the antrum simulator assembly 1 further comprises a second transmission mechanism 16 and a second driving mechanism 17, wherein the second transmission mechanism 16 is connected to the piston 13, and the second driving mechanism 17 drives the second transmission mechanism 16 to drive the piston 13 to move upwards; the control mechanism is electrically connected to the second drive mechanism 17 and is configured to control the opening and closing of the second drive mechanism 17. The second transmission mechanism 16 includes a second guide portion 161, a second sliding portion 162, and a second connecting bracket 163, the second guide portion 161 is disposed to extend along the moving direction of the piston 13, the second sliding portion 162 is slidable on the second guide portion 161, and both ends of the second connecting bracket 163 are connected to the piston 13 and the second sliding portion 162, respectively; the second driving mechanism 17 includes a second stepping motor 171, and an output end of the second stepping motor 171 is connected to the second sliding portion 162. The second guide portion 161 is configured to limit the second sliding portion 162 to reciprocate along a preset movement direction of the piston 13, the second stepping motor 171 is configured to output a linear displacement to the second sliding portion 162, and the second sliding portion 162 drives the piston 13 to move upward through the second connecting bracket 163.

It should be noted that, in other alternative embodiments, the second transmission mechanism may also adopt other transmission modes, for example, the second transmission mechanism may also include a transmission belt, a driving wheel and a driven wheel which are mutually matched, the driving wheel is connected to the output end of the second driving mechanism, and the transmission belt drives the second connecting bracket to reciprocate, so as to drive the inner cylinder to reciprocate.

The antrum gastric simulator assembly 1 can also have a cleaning state, water is injected into the accommodating cavity 10 in the cleaning state, and the inside of the accommodating cavity 10 is cleaned through the reciprocating motion of the inner cylinder 12.

As a preferred embodiment, a predetermined minimum distance is provided between the lower end surface of the inner cylinder 12 at the grinding hole 121 and the top surface of the piston 13, and the minimum distance is 20mm, which can avoid over-grinding the material. The antrum simulator assembly 1 further comprises a limit sensor (not shown) disposed on the piston 13 and/or the inner cylinder 12 and adapted to detect a distance between a lower end surface of the inner cylinder 12 at the grinding hole 121 and a top surface of the piston 13, the limit sensor being in signal connection with the control mechanism. Wherein, through setting up spacing sensor, can detect the distance between the top surface of the lower terminal surface of the grinding hole 121 department of inner tube 12 and piston 13, when this distance is less than preset minimum interval, spacing sensor sends the signal to control mechanism, and control mechanism received signal controls inner tube 12 stop motion or reverse motion to prevent mechanical ground medicine.

The moving speed range of the inner barrel 12 is adjustable from 5mm/s to 50mm/s, the moving speed of the inner barrel 12 is adjustable, and different grinding forces or shearing forces can be simulated according to requirements. The inner cylinder 12 is detachably connected with the outer cylinder 11, and the inner cylinder 12 is detachably connected with the outer cylinder 11, so that the inner cylinder 12 and the outer cylinder 11 can be conveniently installed and maintained. The diameter of the grinding hole 121 ranges from 8mm to 16mm, and specifically may be 8mm, 10mm, 12mm, 16mm, or the like. The diameter of the grinding holes 121 is between 8mm and 16mm, and the grinding holes are suitable for medicines with different sizes.

The antrum simulation assembly 1 further comprises a first sealing member 18 for sealing between the outer wall surface of the piston 13 and the inner wall surface of the inner cylinder 12, and the antrum simulation assembly 1 further comprises a second sealing member 19 for sealing between the outer wall surface of the inner cylinder 12 and the inner wall surface of the outer cylinder 11. The first and second seals 18 and 19 are used to seal between the piston 13 and the inner cylinder 12 and between the inner cylinder 12 and the outer cylinder 11. Specifically, the first seal 18 and the second seal 19 are O-rings or soft gaskets.

In the present embodiment, the inner tube 12, the outer tube 11, and the piston 13 are made of stainless steel, and it is necessary to seal them using a seal such as a soft gasket. In other alternative embodiments, the inner cylinder 12, the outer cylinder 11 and the piston 13 may also be made of ceramic and processed by integral molding, and the ceramic integral molding does not need to be provided with a sealing ring, and has the advantages of acid resistance, alkali resistance, wear resistance, long service life and the like.

The present embodiment also provides a gastric motility simulator 100 comprising the antrum simulator assembly 1 described above. The gastric antrum simulation assembly 1 is adopted in the gastric motility simulation device 100, so that the gastric motility simulation device 100 can simulate the violent peristalsis process of the gastric antrum correspondingly, the simulation of the whole stomach is perfected, and the accuracy of the experimental result is improved.

The gastric motility simulator 100 further comprises a stirring assembly 2, the stirring assembly 2 comprises a stirrer 21 and a hopper 22, the output end of the stirrer 21 extends into the hopper 22, and the hopper 22 is provided with a discharge hole used for conveying materials to the accommodating cavity 10. The hopper 22 is used for containing initial materials, and the purpose of mixing and dissolving media is achieved through stirring at the output end of the stirrer 21, so that the process of mixing food by stomach peristalsis at the upper part of the gastric antrum is simulated; the mixed material enters the accommodating cavity 10 through the discharge hole.

The discharge port is positioned at the bottom of the hopper 22, the aperture of the discharge port is consistent with the outer diameter of the outer cylinder 11, the hopper 22 is sleeved on the outer cylinder 11 and is connected with a sealing ring through a stainless steel hoop, and the electromagnetic valve 27 is installed at the discharge port to control the feeding amount of the mixture to the inner cylinder 12.

The stirrer 21 adopts propeller type stirring, the stirrer 21 comprises two propeller blades and a propeller shaft 222, the stirring assembly 2 further comprises a stirring motor 23, the stirring motor 23 is arranged at the top of the stirrer 21, and the output end of the stirring motor 23 is connected to the propeller shaft 222. The working rotating speed is higher, and the highest adjustable control rotating speed is 200 r/min. The paddle extends into the bottom position of the central shaft of the hopper 22, and the purpose of mixing and dissolving the medium is achieved through bottom stirring, so that the process of mixing the food by the peristaltic action of the stomach main body is simulated. The outer edge of the propeller blade is close to the inner wall of the hopper but is not in contact with the inner wall of the hopper, so that on one hand, the stirring material can be fully stirred without dead volume, and on the other hand, the blade and the hopper can be prevented from scraping to generate scraps to pollute the material.

The stirring assembly 2 may further include a PH probe (not shown) extending into the hopper 22 for on-line checking of PH of the material to facilitate PH adjustment. Through setting up the PH probe, can directly go on in the hopper to the allotment of waiting to cut the material.

The antrum gastric simulator assembly 1 may further include a three-way valve 24, a first opening of the three-way valve 24 is communicated with a discharge port of the hopper 22, a second opening of the three-way valve 24 is communicated with the accommodating chamber 10, a third opening of the three-way valve 24 is communicated with a receiving tray, and the receiving tray is used for placing materials discharged from the accommodating chamber 10. A path between the first opening and the second opening of the three-way valve 24 is used for the material in the feeding hopper 22 to enter the accommodating cavity 10; the passage between the second opening and the third opening is used for discharging the material in the accommodating cavity 10 to the receiving tray. The three-way valve 24 is adopted, so that the structure is simple, and the operation and the installation are convenient. The small holes are formed in the material receiving disc, after the medicine enters the material receiving disc, an operator can observe the state of the medicine, and the liquid material can leak out through the small holes in the material receiving disc.

In the present embodiment, as shown in fig. 1 to 3, the inner cylinder 12, the outer cylinder 11, and the piston 13 are vertically disposed, the inner cylinder 12 moves up and down, the first opening is located at the top of the three-way valve 24, the second opening is located at the bottom of the three-way valve 24, and the third opening is located at the side of the three-way valve 24. When discharging material, the piston 13 moves upwards, pushing material from the bottom of the three-way valve 24 into the side of the three-way valve 24, however this configuration will cause a portion of material to remain in the three-way valve 24 when discharging material. In other alternative embodiments, the inner cylinder 12, the outer cylinder 11 and the piston 13 may be arranged horizontally, the inner cylinder moves horizontally inside the outer cylinder, the first opening is located at the top of the three-way valve, and the second opening and the third opening are located at two opposite sides of the three-way valve.

The gastric motility simulator 100 further comprises an electric heating and heat insulating system, the electric heating and heat insulating system comprises a heater and a temperature control system, the heater is annularly arranged outside the outer barrel 11, and the temperature control system controls the power of the heater according to the temperature in the accommodating cavity 10. The heater is used for heating the accommodating cavity 10, and when the temperature reaches the set temperature, the temperature control system controls the heating power of the heater according to the temperature return difference.

The gastric motility simulator 100 also includes a safety protection system including a leakage protector and a buzzer connected to the electrical heating and insulation system. The safety protection system is used for providing overload and short-circuit protection functions when electric leakage faults occur to equipment, and the buzzer is mainly based on the piezoelectric effect of piezoelectric ceramics to drive the metal sheet to vibrate and sound.

The gastric motility simulator 100 further comprises a PLC control system, and the output end of the PLC control system is electrically connected to the driving mechanism, the electric heating and heat preservation system and the safety protection system of the gastric antrum simulation assembly 1. The PLC control system is used for controlling the overall operation, executing instructions facing users, such as logic operation, sequence control, timing and the like, and controlling an operation program through digital input and output.

The gastric motility simulator 100 further comprises an outer shell 25, the antrum simulator assembly 1 is located inside the outer shell 25, and the stirring assembly 2 is located above the outer shell 25. The antrum gastric simulation assembly 1 is positioned in the outer shell 25, and the outer shell 25 plays a role in protecting the antrum gastric simulation assembly 1; the stirring assembly 2 is positioned above the outer shell 25, so that an operator can conveniently pour materials into the stirring assembly 2 and observe the mixing condition of the materials. The outer housing 25 may have dimensions of a total height of 1.6m, a width of 0.45m and a length of 0.45 m.

The gastric motility simulator 100 may also include rolling elements disposed at the bottom of the outer housing 25. The bottom is provided with a rolling piece for convenient movement.

The gastric motility simulator 100 can also include a human-machine interface electrically connected to the input and output of the PLC control system. An operator can input instructions such as volume parameters and running speed to the PLC control system through a human-computer interaction interface, and the human-computer interaction interface can display various information such as real-time positions and running speeds of the inner barrel 12 and the piston rod 131 through graphs. The human-computer interaction interface may specifically comprise a touch screen 26.

The gastric motility simulator 100 may also include baffles attached to the top and bottom surfaces of the outer shell 25. The baffle is used to separate the antrum simulation assembly 1 from the PLC control system, i.e. to isolate the electrical and mechanical parts. Specifically, the baffle is arranged in parallel with the front and rear side plates of the housing, separating the inner space of the housing body 25 into a front side and a rear side, the antrum simulation module 1 is located at the front side, and the PLC control system is located at the rear side.

In other alternative embodiments, baffles are also provided parallel to the left and right side plates of outer housing 25, dividing the interior space of outer housing 25 into left and right sides, with antrum simulation assembly 1 on the left side and the PLC control system on the right side, or vice versa. The device is smaller and more compact due to the arrangement, and can be placed on a laboratory bench for use.

The following information may be displayed on the touch screen 26: the volume of the accommodating cavity 10, the running speed of the inner cylinder 12, the temperature of the accommodating cavity 10, the cycle time, the number of cycles per hour, and the real-time positions of the inner cylinder 12 and the piston 13.

An operating button 28 is also provided below the touch screen 26 to input instructions to the PLC control system. The operation buttons 28 may include a volume adjusting slide switch of the receiving chamber 10, an operation speed slide switch of the inner cylinder 12, a temperature adjusting switch of the receiving chamber 10, a cycle time adjusting switch, and a number of cycles per hour adjusting switch.

In this embodiment, the operation of the gastric motility simulator 100 may comprise the steps of:

s1, inserting a power supply to supply power to the gastric motility simulation device 100 and turning on the heater.

And S2, starting the stirrer 21, setting the stirring time by an operator, and starting stirring by the stirrer 21 according to an instruction after the prepared medium and the medicines are filled into the hopper 22.

S3, the stomach dynamic simulation device 100 loads the mixture into the inner cylinder 12 according to the instruction.

S4, an operator clicks the touch screen 26 to set the peristaltic volume, the running speed and the peristaltic time to start running, the inner cylinder 12 controls the travel track according to the set peristaltic volume, and the dead volume of 20mm above the top of the piston rod 131 is kept at the lowest running point to prevent mechanical grinding of the medicine.

And S5, when the operation is finished, the piston rod 131 is operated upwards according to the instruction to push out the mixture, and the grinding state of the medicines in the mixture is observed.

And S6, setting the cleaning time by an operator, operating the device in a cleaning mode, and after the program is finished, operating the piston rod 131 upwards according to the instruction to remove the waste liquid.

In this embodiment, the PLC control system may include the following functions:

the volume of the inner cylinder 12 can be selected within 250 ml, the control method is that volume parameters are selected through the touch screen 26 before feeding, the PLC sends out an instruction, the inner cylinder 12 runs to a certain position, and the piston 13 runs to the top of the inner cylinder 12;

the continuous operation speed parameter of the inner cylinder 12 is selected through the touch screen 26, and the PLC control system automatically calculates the reverse compensation operation speed of the piston 13, so that the total volume of the inner cylinder 12 and the outer cylinder 11 can be kept unchanged during continuous operation;

when discharging, the PLC control system sends an instruction, and the piston 13 slowly runs to the top of the inner cylinder 12 and upwards runs to the top at the same speed as the inner cylinder 12;

when the circulation operation times and the intermittent time per hour are selected for cleaning or intermittent operation, the PLC control system automatically calculates the operation speed of the inner cylinder 12 and the piston rod 131;

after the total operation time is selected through the touch screen 26, the PLC control system stops sending instructions after finishing the operation cycle of the last inner cylinder 12 and the piston rod 131 after reaching the selected time, rings and flickers the red light;

if the resistance of the inner cylinder 12 and the piston 13 exceeds the limit, the PLC control system sends out an instruction to stop running and give an alarm;

when the PLC control system continuously or intermittently operates, the PLC control system sends an instruction to stop operating or recover operating, and the stop time does not account for the total operating time;

the temperature in the cylinder can be selected through a touch switch, the temperature sensor in the cylinder senses the temperature in the cylinder through an analog-digital input module of a PLC control system, a heater in the thermal insulation box is instructed to work when the temperature is too low, and the heater in the thermal insulation box is instructed to stop working or a fan is started to cool when the temperature is too high;

the PLC control system can graphically display various information such as real-time positions and operation information of the inner cylinder 12 and the piston 13 on the touch screen 26.

Although specific embodiments of the present invention have been described above, it will be understood by those skilled in the art that this is by way of example only and that the scope of the invention is defined by the appended claims. Various changes and modifications to these embodiments may be made by those skilled in the art without departing from the spirit and the principles of the present invention, and these changes and modifications are all within the scope of the present invention.

Claims (15)

1. The utility model provides a gastric antrum simulation subassembly for stomach dynamic simulation device, a serial communication port, gastric antrum simulation subassembly includes urceolus and grinding portion, grinding portion activity is located the inside of urceolus, be provided with the grinding hole in the grinding portion, the grinding portion is followed the extending direction of urceolus for but urceolus reciprocating motion, so that the grinding hole passes and is located the inside material of urceolus.

2. The antrum simulator of claim 1, wherein the polishing portion is an inner tube, the polishing hole is located at the top of the inner tube, the outer tube is sleeved outside the inner tube, and the outer wall of the inner tube is closely attached to the inner wall of the outer tube.

3. The antrum gastric simulator assembly of claim 2, wherein the inner cylinder comprises a cylinder body and a bushing, the bushing is detachably connected to the top of the cylinder body, the middle of the bushing is provided with the grinding hole, and the outer side wall of the bushing is closely attached to the inner side wall of the outer cylinder and/or the outer side wall of the cylinder body is closely attached to the inner side wall of the outer cylinder.

4. The antrum gastric simulator assembly of claim 2, further comprising a piston disposed within the inner barrel, the piston including a piston rod and a barrier connected to the piston rod, the barrier having a peripheral wall that conforms closely to the inner sidewall of the inner barrel.

5. The antrum simulator assembly of claim 4, wherein the antrum simulator assembly has a first motion state in which the outer cylinder and the piston are relatively stationary and the inner cylinder undergoes the reciprocating motion relative to the outer cylinder and the piston;

the inner barrel is provided with a first limit position and a second limit position, and when the inner barrel is located at the first limit position, the top surface of the inner barrel is close to or abutted against the top of the outer barrel; when the inner cylinder is positioned at the second limit position, the lower end surface of the grinding hole of the inner cylinder is close to the top surface of the piston.

6. The antrum simulation assembly of claim 4, wherein the antrum simulation assembly has a second motion state in which the piston moves upward to push the material out of the outer cylinder.

7. The antrum simulation assembly of claim 4, wherein the antrum simulation assembly has a transmission mechanism coupled to the inner barrel and a drive mechanism that drives the transmission mechanism to reciprocate the inner barrel;

the antrum gastric simulation assembly further comprises a control mechanism electrically connected to the drive mechanism and used for controlling the opening and closing of the drive mechanism.

8. The antrum simulator assembly according to claim 7, wherein the transmission mechanism includes a guide portion extending in a movement direction of the inner cylinder, a sliding portion slidable on the guide portion, and a connection bracket having both ends connected to the inner cylinder and the sliding portion, respectively;

the driving mechanism comprises a stepping motor, and the output end of the stepping motor is connected to the sliding part.

9. The antrum simulation assembly of claim 7, further comprising a position limit sensor disposed on the piston and/or the inner barrel for detecting a distance between a lower end surface at the grinding aperture of the inner barrel and a top surface of the piston, the position limit sensor being in signal communication with the control mechanism.

10. The antrum simulation assembly of any of claims 4-9, wherein the inner barrel has a speed of movement that is adjustable in a range between 5mm/s and 50 mm/s;

and/or a preset minimum distance is reserved between the lower end surface of the grinding hole and the top surface of the piston, and the minimum distance is 20 mm;

and/or the inner cylinder is detachably connected with the outer cylinder;

and/or the diameter of the grinding holes ranges between 8mm and 16 mm;

and/or the antrum simulation assembly further comprises a first sealing element for sealing between the outer wall surface of the piston and the inner wall surface of the inner barrel;

and/or the antrum simulation assembly further comprises a second sealing element for sealing between the outer wall surface of the inner cylinder and the inner wall surface of the outer cylinder.

11. Gastric motility simulation device comprising a antrum simulation assembly according to any of claims 1 to 10.

12. The gastric motility simulator of claim 11, further comprising a stirring assembly, said stirring assembly comprising a stirrer and a hopper, an output of said stirrer extending into an interior of said hopper, said hopper having a discharge port for delivering material to said antrum simulation assembly.

13. The gastric motility simulator of claim 12, wherein the antrum simulator assembly further comprises a three-way valve, a first opening of the three-way valve being in communication with the hopper, a second opening of the three-way valve being in communication with the outer barrel, and a third opening of the three-way valve being in communication with a receiving tray for receiving material discharged from the antrum simulator assembly.

14. The gastric motility simulator according to claim 12, further comprising an electrical heating and warming system, said electrical heating and warming system comprising a heater disposed around the exterior of the outer barrel and a temperature control system for controlling the power of said heater in response to the temperature within the outer barrel;

and/or the gastric motility simulation device also comprises a safety protection system, wherein the safety protection system comprises a leakage protector and a buzzer which are connected with the electric heating and heat preservation system;

and/or, the stomach dynamic simulation device still includes PLC control system, PLC control system's output electricity connect in the actuating mechanism of stomach sinus simulation subassembly, electrical heating heat preservation system with the safety protection system.

15. The gastric motility simulator of claim 14, further comprising an outer housing, the antrum simulation assembly being located inside the outer housing, the agitation assembly being located above the outer housing;

and/or the gastric motility simulating device further comprises a rolling piece, the rolling piece is arranged at the bottom of an outer shell, the gastric antrum simulating assembly is positioned in the outer shell, and the stirring assembly is positioned above the outer shell;

and/or the gastric motility simulator also comprises a human-computer interaction interface which is electrically connected with the input end and the output end of the PLC control system;

and/or, the stomach dynamic simulation device still includes the baffle, the baffle connect in the top surface and the bottom surface of shell body, PLC control system with the stomach sinus simulation subassembly is located respectively the both sides of baffle.

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