CN114527246B - Cardiovascular and cerebrovascular medicine research and development check out test set - Google Patents
Cardiovascular and cerebrovascular medicine research and development check out test set Download PDFInfo
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- CN114527246B CN114527246B CN202210147085.0A CN202210147085A CN114527246B CN 114527246 B CN114527246 B CN 114527246B CN 202210147085 A CN202210147085 A CN 202210147085A CN 114527246 B CN114527246 B CN 114527246B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a cardiovascular and cerebrovascular medicine research and development detection device, relates to the field of medicine detection, and aims at solving the problems that medicine detection does not have authenticity, is difficult to detect and the like. According to the invention, the supporting disc is influenced by the spiral tube to contact the winding part of the resin hose, so that the resin hose moves slowly and regularly along with the supporting disc, the peristaltic environment of the stomach intestinal tract is simulated, the tablet is dissolved in the resin hose in a reaction way with the acid solution, meanwhile, carbon dioxide and oxygen in the resin hose simulate the stomach environment of a human body under the action of the acid solution, and steam with temperature is filled into the two ventilation pipes, so that the temperature in the top shell is kept constant, the stomach environment of the human body is simulated to the greatest extent, and the detection has authenticity.
Description
Technical Field
The invention relates to the field of drug detection, in particular to a cardiovascular and cerebrovascular drug research and development detection device.
Background
The common drugs for cardiovascular and cerebrovascular diseases include aspirin, clopidogrel, ticagrelor and the like, and can inhibit the aggregation and release of platelets through different ways and prevent the formation of arterial thrombosis; atorvastatin, rosuvastatin, pitavastatin and the like have the effects of protecting vascular endothelium, resisting inflammation, stabilizing atherosclerosis plaques and the like while reducing blood fat, can effectively reduce cardiovascular and cerebrovascular dangerous events, calcium ion antagonists and the like, and often do a lot of detection on medicines in the research and development stage of medicines, wherein the detection of the existing means for simulating human body absorption and the reaction of the medicines in human bodies is complex and difficult, and is unfavorable for effective detection, so that the research and development detection equipment for the cardiovascular and cerebrovascular medicines is provided to cope with the defects of the prior art.
Disclosure of Invention
Object of the invention
In order to solve the technical problems in the background technology, the invention provides a cardiovascular and cerebrovascular medicine research and development detection device, wherein the output end of a driving servo motor in the invention rotates a reciprocating threaded rod, so that a coil starts to reciprocate up and down in an outer ring fiber area of the reciprocating threaded rod, and a support tray is contacted with a winding part of a resin hose under the influence of the coil, so that the resin hose moves up and down slowly and regularly along with the support tray, thereby simulating the peristaltic environment of stomach intestinal tracts, a tablet is reacted and dissolved with an acidic solution in the resin hose, carbon dioxide and oxygen in the resin hose simulate the environment of human stomach under the action of the acidic solution, and steam with temperature is filled into two ventilation pipes, so that the temperature in a top shell is kept constant, the stomach environment of the human body is simulated to the greatest extent, and the detection has authenticity.
(II) technical scheme
The invention provides a cardiovascular and cerebrovascular medicine research and development detection device, which comprises a bottom shell, wherein a top shell is welded at the top of the bottom shell, a sealing ring is welded around an inner ring of a top through hole of the top shell, a sleeve hole is formed in the sealing ring, a connecting pipe penetrating through and extending to the inside of the top shell is sleeved on an inner ring of the sleeve hole, a funnel is welded on an outer ring of the connecting pipe, a wedge-shaped sealing plug is arranged on the top through hole of the funnel, a resin hose is fixedly connected to one end of the connecting pipe, which is positioned in the top shell, one end of the resin hose, which is far away from the connecting pipe, penetrates through and extends to the outside of the top shell, a driving servo motor is fixedly arranged on the inner wall at the bottom of the bottom shell through a bolt, a reciprocating threaded rod is welded at the output end of the driving servo motor, a screw pipe is sleeved on an outer ring thread of the reciprocating threaded rod, and a bearing tray is welded on the outer ring of the screw pipe.
As a preferable scheme of the invention, a limiting block is welded at one end of the reciprocating threaded rod, which is far away from the driving servo motor, the diameter of the cross section of the limiting block is larger than that of the cross section of the screw tube, and the limiting block prevents the screw tube from being separated from the movement range of the outer ring of the reciprocating threaded rod.
As a preferable scheme of the invention, the periphery of the inner ring of the bottom shell is welded with the liquid retention groove, the top of the liquid retention groove is sleeved with four ventilation pipes penetrating through and extending out of the bottom shell, the ventilation pipes are distributed in an annular array with the center of the liquid retention groove, two ventilation pipes corresponding to each other in a crossing way are filled with steam with temperature, so that the temperature inside the top shell is kept constant, and meanwhile, condensed water vapor on the inner wall of the top shell slides down and is accumulated through the liquid retention groove while the steam is filled, and flows out of the top shell through another pair of ventilation pipes corresponding to each other.
As a preferable scheme of the invention, a bent column is welded on one side edge of the top shell, a placing table is welded on one end of the bent column far away from the top shell, and a storage groove is formed in the top of the placing table.
As a preferable scheme of the invention, one end of the resin hose, which is positioned outside the top shell, is provided with a valve, and the valve is provided with a valve switch.
As a preferable scheme of the invention, the inside of the resin hose is filled with the acid solution, the acid solution is filled with carbon dioxide and oxygen, the tablet reacts with the acid solution to be dissolved in the inside of the resin hose, and the carbon dioxide and the oxygen in the resin hose simulate the environment of human stomach under the action of the acid solution.
Compared with the prior art, the technical scheme provided by the invention has the following beneficial technical effects:
in summary, the output end of the driving servo motor in the invention rotates the reciprocating threaded rod, so that the spiral tube starts to reciprocate up and down in the outer ring fiber area of the reciprocating threaded rod, and meanwhile, the supporting tray is influenced by the spiral tube to contact the winding part of the resin hose, so that the resin hose moves up and down slowly and regularly along with the supporting tray, thereby simulating the peristaltic environment of stomach intestinal tracts, the tablet reacts with the acidic solution in the resin hose to dissolve, and simultaneously, carbon dioxide and oxygen in the resin hose simulate the stomach environment of a human body under the action of the acidic solution, and steam with temperature is filled into the two ventilation pipes, so that the temperature in the top shell is kept constant, the stomach environment of the human body is simulated to the greatest extent, and the detection has reality.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required to be used in the embodiments or the description of the prior art will be briefly described below, and it is obvious that the drawings in the following description are only embodiments of the present invention, and that other drawings can be obtained according to the provided drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural diagram of a cardiovascular and cerebrovascular drug research and development detection device according to the present invention.
Fig. 2 is a schematic diagram of a resin hose structure of a cardiovascular and cerebrovascular drug development and detection device according to the present invention.
Fig. 3 is a schematic diagram of a structure of a liquid sump of a cardiovascular and cerebrovascular drug development and detection device according to the present invention.
Fig. 4 is a schematic diagram of a seal ring structure of a cardiovascular and cerebrovascular drug development and detection device according to the present invention.
Fig. 5 is a schematic diagram of a driving servo motor of a cardiovascular and cerebrovascular drug research and development detection device according to the present invention.
Reference numerals: 1. a bottom case; 2. a top shell; 3. a placement table; 4. a connecting pipe; 5. a seal ring; 6. a resin hose; 7. a vent pipe; 8. a liquid retention tank; 9. driving a servo motor; 10. a reciprocating threaded rod; 11. a tray; 12. a solenoid; 13. a limiting block; 14. a funnel; 15. wedge-shaped sealing plug.
Detailed Description
The following description is merely exemplary in nature and is not intended to limit the present disclosure, application, or uses. It should be understood that throughout the drawings, the same or similar reference numerals indicate the same or similar parts and features. The drawings merely schematically illustrate the concepts and principles of embodiments of the disclosure and do not necessarily illustrate the specific dimensions and proportions of the various embodiments of the disclosure. Specific details or structures may be shown in exaggerated form in particular figures to illustrate related details or structures of embodiments of the present disclosure.
Embodiment one: referring to fig. 1-5, a cardiovascular and cerebrovascular medicine research and development detection device comprises a bottom shell 1, a top shell 2 is welded at the top of the bottom shell 1, a sealing ring 5 is welded around the inner ring of a top through hole of the top shell 2, a sleeve hole is formed in the inner part of the sealing ring 5, a connecting pipe 4 penetrating through and extending to the inside of the top shell 2 is sleeved in the inner ring of the sleeve hole, a funnel 14 is welded on the outer ring of the connecting pipe 4, a wedge-shaped sealing plug 15 is arranged at the top through hole of the funnel 14, a resin hose 6 is fixedly connected to one end of the connecting pipe 4 in the top shell 2, tablets or medicines for treating cardiovascular and cerebrovascular diseases are put into the funnel 14, the tablets are slid into the inside of the resin hose 6 under the guiding action of a curved surface with inclination of the funnel 14, one end of the resin hose 6 far away from the connecting pipe 4 penetrates and extends to the outside of the top shell 2, a driving servo motor 9 is fixedly mounted on the bottom inner wall of the bottom shell 1 through a bolt, a threaded rod 12 is welded at the output end of the driving servo motor 9, a threaded rod 12 is sleeved on the outer ring of the threaded rod 10 in a threaded sleeve of the threaded rod of the reciprocating mode, a supporting disk 11 is welded on the outer ring of the threaded rod 12, the output end of the driving servo motor 9 rotates the threaded rod 10, the threaded rod 12 is fixedly rotates, the threaded rod 12 is positioned at the threaded rod 12, the threaded rod 12 is positioned at the end of the outer ring of the threaded rod 12, the threaded rod 4 slides under the threaded rod 4, the end of the driving servo motor 4 is under the driving the threaded rod 4, the threaded rod 4 is wound on the inner ring 4 is under the threaded rod 6, and the inner ring 6 is contacted with the inner ring 12 and runs through the threaded rod 6 and runs through the driving rod 6 and runs through the threaded rod 6.
Embodiment two: referring to fig. 1-5, based on the first embodiment, a limiting block 13 is welded at one end of a reciprocating threaded rod 10 far away from a driving servo motor 9, the cross section diameter of the limiting block 13 is larger than that of a solenoid 12, a liquid-holding tank 8 is welded around the inner ring of a bottom shell 1, four ventilation pipes 7 penetrating through and extending out of the bottom shell 1 are sleeved at the top of the liquid-holding tank 8, the ventilation pipes 7 are distributed in an annular array with the center of the liquid-holding tank 8, a bent column is welded at one side edge of a top shell 2, a placing table 3 is welded at one end of the bent column far away from the top shell 2, a storage groove is formed at the top of the placing table 3, a valve is arranged at one end of the resin hose 6 located outside the top shell 2, a valve switch is arranged on the valve, an acidic solution is filled in the interior of the resin hose 6, carbon dioxide and oxygen are filled in the acidic solution, the valve at the tail end of the resin hose 6 is opened after the reaction is completed, the solution dissolved in the interior of the resin hose 6 and the gas inside the resin hose 6 is released, the steps above are repeated after the resin hose 6 is cleaned, and the average time is recorded by a timer.
The working principle and the concrete explanation of the invention:
firstly, the wedge-shaped sealing plug 15 is pulled out, the periphery of the inner ring of the funnel 14 is wiped through gauze soaked with alcohol, then tablets or medicines for treating cardiovascular and cerebrovascular diseases are thrown into the funnel 14, the tablets slide into the inside of the resin hose 6 through the connecting pipe 4 under the guiding action of a curved surface with inclination of the funnel 14, then the wedge-shaped sealing plug 15 is plugged again to the top of the funnel 14, the resin hose 6 which is not contacted with the inner wall of the top shell 2 forms a space with the top shell 2, the tablets at the moment react with an acidic solution in the inside of the resin hose 6 to be dissolved, carbon dioxide and oxygen in the resin hose 6 simulate the environment of human stomach under the action of the acidic solution, meanwhile, the power supply of the driving servo motor 9 is connected, so that the output end of the driving servo motor 9 rotates to reciprocate the threaded rod 10, then the threaded pipe 12 starts to reciprocate at the outer ring fiber area of the reciprocating threaded rod 10, and simultaneously the supporting disc 11 is contacted with the winding part of the resin hose 6 under the influence of the threaded pipe 12, so that the resin hose 6 slowly moves up and down along with the supporting disc 11, the intestinal peristalsis environment is simulated, and the time of the tablet is placed above the supporting disc 3 is recorded regularly.
The medicine reaction is carried out, two corresponding ventilation pipes 7 are filled with steam with temperature, the temperature inside the top shell 2 is kept constant, meanwhile, the steam condensed on the inner wall of the top shell 2 slides down and is gathered through a liquid storage tank 8 while the steam is filled, the steam flows out of the top shell 2 through the other pair of corresponding ventilation pipes 7, specifically, the top shell 2 is made of transparent materials such as acrylic, the reaction condition inside the resin hose 6 can be effectively and clearly seen, further, after the dissolution of the tablets is completed, a timer on the placing table 3 is pressed down to record the detection time, a driving servo motor 9 is closed, meanwhile, a valve at the tail end of the resin hose 6 is opened, the solution dissolved inside the resin hose 6 and the gas inside the resin hose 6 are released, the steps are carried out again after the resin hose 6 is repeatedly cleaned, and the average time recorded by the timer is obtained.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (7)
1. The utility model provides a cardiovascular and cerebrovascular medicine research and development check out test set, includes drain pan (1), a serial communication port, the top welding of drain pan (1) has top shell (2), the top through-hole inner circle welding of top shell (2) has sealing ring (5) all around, trepanning has been seted up to the inside of sealing ring (5), and the inner race cover of trepanning is equipped with and runs through and extends to inside connecting pipe (4) of top shell (2), the outer lane welding of connecting pipe (4) has funnel (14), the top through-hole of funnel (14) is provided with wedge sealing plug (15), one end fixedly connected with resin hose (6) that connecting pipe (4) are located the inside of top shell (2), the one end that connecting pipe (6) kept away from connecting pipe (4) runs through and extends to the outside of top shell (2), the bottom inner wall of drain pan (1) has drive servo motor (9) through bolt fixed mounting, the output welding of drive servo motor (9) has reciprocal threaded rod (10), the outer lane thread bush of threaded rod (10) is equipped with screwed pipe (12), bearing disc (11) are influenced by the resin hose (11) and the support disc is contacted with the hose (11) slowly along with the flexible carrier disc that the flexible disc is welded down.
2. The cardiovascular and cerebrovascular medicine research and development detection device according to claim 1, wherein a limiting block (13) is welded at one end of the reciprocating threaded rod (10) far away from the driving servo motor (9), and the cross section diameter of the limiting block (13) is larger than that of the solenoid (12).
3. The cardiovascular and cerebrovascular medicine research and development detection device according to claim 1, wherein the inner ring of the bottom shell (1) is welded with a liquid holding tank (8), four ventilation pipes (7) penetrating and extending out of the bottom shell (1) are sleeved at the top of the liquid holding tank (8), and the ventilation pipes (7) are distributed in an annular array with the center of the liquid holding tank (8).
4. The cardiovascular and cerebrovascular medicine research and development detection device according to claim 1, wherein a bent column is welded on one side edge of the top shell (2), a placement table (3) is welded on one end of the bent column far away from the top shell (2), and a placement groove is formed in the top of the placement table (3).
5. The cardiovascular and cerebrovascular medicine research and development detection device according to claim 1, wherein a valve is arranged at one end of the resin hose (6) outside the top shell (2), and a valve switch is arranged on the valve.
6. The cardiovascular and cerebrovascular medicine development detection device according to claim 1, wherein the resin hose (6) is internally filled with an acidic solution, and the acidic solution is filled with carbon dioxide and oxygen.
7. The cardiovascular and cerebrovascular drug development detection apparatus according to any one of claims 1-6, further comprising the following operational use procedures:
the method comprises the steps of pulling out a wedge-shaped sealing plug (15), wiping the periphery of the inner ring of a funnel (14) through gauze soaked with alcohol, then throwing tablets or medicines for treating cardiovascular and cerebrovascular diseases into the funnel (14), sliding the tablets into the inside of a resin hose (6) through a connecting pipe (4) under the action of curved surface guidance of the slope of the funnel (14), then re-plugging the wedge-shaped sealing plug (15) back to the top of the funnel (14), enabling the resin hose (6) which is not contacted with the inner wall of a top shell (2) to form a space with the top shell (2), enabling the tablets at the moment to react and dissolve with an acidic solution in the inside of the resin hose (6), enabling carbon dioxide and oxygen in the resin hose (6) to simulate the environment of the stomach of a human body under the action of the acidic solution, enabling a power supply for driving a servo motor (9) to be connected, enabling an output end of the servo motor (9) to rotate a reciprocating threaded rod (10), enabling the coil (12) to start to reciprocate up and down in a fiber area of the outer ring of the reciprocating threaded rod (10), enabling a supporting disc (11) to be contacted with the inner wall of the top shell (2) to form a space, enabling the tablet to react and dissolve with the acidic solution, enabling the upper portion (6) to be slowly placed on the upper portion of the table (6) to be in a regular time, and then the environment is recorded;
when the medicine reacts, two corresponding ventilation pipes (7) are filled with steam with temperature, so that the temperature inside the top shell (2) is kept constant, meanwhile, when the steam is filled, water vapor condensed on the inner wall of the top shell (2) slides down and is gathered through a liquid storage tank (8), and flows out of the top shell (2) through the other pair of corresponding ventilation pipes (7), specifically, the top shell (2) is made of acrylic materials, the reaction condition inside the resin hose (6) can be effectively and clearly seen, the timer on the placing table (3) is pressed after the tablet is dissolved, the detection time is recorded, the driving servo motor (9) is closed, meanwhile, the valve at the tail end of the resin hose (6) is opened, the solution dissolved inside the resin hose (6) and the gas inside the resin hose (6) are released, the steps above are repeated after the resin hose (6) is cleaned, and the average time recorded by the timer is obtained.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210147085.0A CN114527246B (en) | 2022-02-17 | 2022-02-17 | Cardiovascular and cerebrovascular medicine research and development check out test set |
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| CN202210147085.0A CN114527246B (en) | 2022-02-17 | 2022-02-17 | Cardiovascular and cerebrovascular medicine research and development check out test set |
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| CN114527246A CN114527246A (en) | 2022-05-24 |
| CN114527246B true CN114527246B (en) | 2023-07-25 |
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