CN109324162B - A experimental apparatus that disintegrates for inspection of medicine tablet - Google Patents
A experimental apparatus that disintegrates for inspection of medicine tablet Download PDFInfo
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- CN109324162B CN109324162B CN201811257890.9A CN201811257890A CN109324162B CN 109324162 B CN109324162 B CN 109324162B CN 201811257890 A CN201811257890 A CN 201811257890A CN 109324162 B CN109324162 B CN 109324162B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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Abstract
The invention provides a disintegration experimental device for checking pharmaceutical tablets, which comprises a beaker cover and a clamping sleeve; a microcomputer controller is arranged in the base; the control panel is arranged on the front side surface of the base; the heater and the temperature sensor are respectively provided with two parts, are fixed in the box body and are connected with the controller in the base; the support is a rectangular column, a rectangular opening is formed in the side face of the top of the rectangular column, two rectangular sheets are welded to the top ends of the front side faces of the left end and the right end of the opening, and the two rectangular sheets are arranged on the side face of the top of the base and on the rear side of the box body; the invention controls the descending depth and the ascending height of the beaker seat by manually swinging the ratchet wheel, thereby controlling the height of the beaker, the connection relation between all parts is simple, the operation is easy, the rotation motion of the ratchet wheel is limited by the clamping of the directional hook on the ratchet wheel, thereby the height of the beaker is fixed, the disintegration experiment is convenient to carry out, all parts are easy to manufacture and have low cost, the subsequent maintenance cost is low, the maintenance is convenient, and the efficiency is high.
Description
Technical Field
The invention belongs to the technical field of medical experimental equipment, and particularly relates to a disintegration experimental device for pharmaceutical tablet inspection.
Background
The disintegration tester is a drug testing instrument developed according to the regulations of the relevant disintegration time limit detection of tablets, pills and the like in the pharmacopoeia of the people's republic of China.
Chinese patent application No. 201620708155.5 discloses a drug test appearance that disintegrates, including case (1) that disintegrates, the drug test appearance that disintegrates still including establishing disintegration incasement (1) in be used for imbedding medicine (2) and dissolve collapse bag (4) of liquid (3), collapse bag (4) bottom surface and use soft material preparation, collapse bag (4) below still be equipped with be used for with collapse bag (4) bottom surface counterbalance and be used for simulating peristaltic analogue means (5) of stomach, collapse and be equipped with burette (7) on bag (4) lateral wall, be equipped with the acid solution that is used for instiling into solution (3) in burette (7), collapse and still be equipped with one end on bag (4) lateral wall and dip in the pH value of dissolving solution (3) and show meter (8). The invention provides a drug test disintegration tester for simulating gastric peristalsis to accurately detect drug disintegration time limit.
The Chinese patent with the application number of 201620704850.4 discloses a medicine disintegration apparatus, which comprises a disintegration box (1), the medicine disintegration apparatus further comprises a disintegration bag (4) which is arranged in the disintegration box (1) and is used for placing a medicine (2) and a dissolved liquid (3), a simulation device (5) which is used for propping against the bottom surface of the disintegration bag (4) and simulating the peristalsis of the stomach is further arranged below the disintegration bag (4), the simulation device (5) comprises a plurality of air cylinders (5.1) which are arranged below the disintegration bag (4), the air cylinders (5.1) push the bottom surface of the disintegration bag (4) through ejector rods (5.2) at different strokes and frequencies to simulate the peristalsis of the stomach, a dropper (7) is arranged on the side wall of the disintegration bag (4), an acid solution used for dropping the dissolved liquid (3) is arranged in the dropper (7), and an acid display meter (8) with one end immersed in the dissolved liquid (3) is further arranged on the side wall of the disintegration bag (4). The invention provides a drug disintegration tester for simulating gastric peristalsis to accurately detect drug disintegration time limit.
Based on the above, the inventor finds that in a disintegration experiment, the peristalsis of the stomach does not need to be simulated, the simulation device is additionally arranged in heated water and can be gradually hardened along with the increase of the using time, the service life is shortened, the soft substance can also generate other substances in the heating process to influence the experimental data, the disintegration tester can also be used for carrying out disintegration simulation on the intestine part, the stomach simulation device is additionally arranged to limit the function of the disintegration tester, most of the disintegration testers on the market drive a rack by a gear driven by the positive and negative rotation of a motor, and a hanging basket fixed on the rack moves up and down in a beaker to disintegrate the solid preparation. Although the disintegration tester can meet the requirements of users to a certain extent, the disintegration tester has the following disadvantages: by adopting a driving mode of matching a gear with a rack, not only is maintenance performed by frequently adding lubricating oil, but also the phenomenon of gear clamping is easy to occur, the phenomena of gear erosion, gear sliding and the like can occur after the use time is long, the replacement and maintenance cost is high, and the working efficiency of the disintegration tester is influenced; meanwhile, the motor is troublesome to control in forward and reverse rotation, and the service life is influenced.
In view of the above, research and improvement are made on the existing structure and defects, and a disintegration tester for testing pharmaceutical tablets is provided, so as to achieve the purpose of higher practical value.
Disclosure of Invention
In order to solve the technical problems, the invention provides a disintegration experiment device for checking pharmaceutical tablets, which aims to solve the problems of the existing function limitation, easy generation of tooth clamping phenomenon, troublesome control and high maintenance cost.
The invention relates to a disintegration experimental device for checking pharmaceutical tablets, which has the purpose and the effect achieved by the following specific technical means:
a disintegration experiment device for drug tablet inspection comprises a base, a control panel, a display screen, a box body, a heater, a temperature sensor, a bracket, a roller, a lifting mechanism, a ratchet wheel, a reel, a directional hook, a clamping block, a lifting rope, a beaker seat, a beaker cover and a clamping sleeve; a microcomputer controller is arranged in the base; the control panel is arranged on the front side surface of the base; the display screen is arranged on the front side surface of the base and is arranged on the right side of the control panel; the box body is placed on the top side surface of the base, the top part is an open end, a partition plate is arranged in the middle, the inner space is evenly divided into a left part and a right part, and the middle of the front side surface is provided with scale marks; the heater and the temperature sensor are respectively provided with two parts, are fixed in the box body and are connected with the controller in the base; the support is a rectangular column, a rectangular opening is formed in the side face of the top of the rectangular column, two rectangular sheets are welded to the top ends of the front side faces of the left end and the right end of the opening, and the two rectangular sheets are arranged on the side face of the top of the base and on the rear side of the box body; the lifting mechanism consists of a ratchet wheel, a winding wheel, a directional hook and a clamping block, and is connected to the rear side surface of the base at two positions; one end of the lifting rope is connected to the reel, and the other end of the lifting rope penetrates through the two rollers and then is divided into three strands to be fixed on the beaker seat; the beaker is placed in the beaker seat; the beaker cover is a rubber cover and is fixed at the top of the beaker.
Furthermore, the idler wheel is connected to the notch at the top end of the stand column part of the support through a pin shaft, and the other position of the idler wheel is connected between two rectangular plates at the top end of the support through a pin shaft and can rotate along the connecting pin shaft.
Furthermore, the ratchet wheel is provided with sixteen ratchets which are connected to the rear side face of the base through a pin shaft.
Further, the reel is the circle wheel structure that the excircle was equipped with the circular arc slot, through round pin hub connection on the base trailing flank, and between base and ratchet.
Furthermore, the directional hook is an arc-shaped hook, the bottom end of the directional hook is in a tooth shape identical to that of the ratchet wheel, the directional hook is connected to the rear side face of the base through a pin shaft and can rotate around the pin shaft, the directional hook is always kept in a downward state under the action of gravity, and meanwhile, a cylinder is arranged on the side face of the directional hook.
Furthermore, the fixture block is a rectangular step trapezoidal block, the left end face of the fixture block is an arc-shaped face, the radian of the arc-shaped face is the same as that of the directional hook, and the fixture block is fixed on the rear side face of the base through two screws.
Furthermore, the beaker seat is of a circular fence structure, and three round holes are formed in the top of the outer circle and used for being tied to a lifting rope.
Furthermore, the cutting ferrule is a cylindrical leather sheath structure, and is annularly distributed on the bottom side surface of the beaker cover, wherein six positions are provided in total.
Compared with the prior art, the invention has the following beneficial effects:
the arrangement of the clamping block is favorable for limiting the rotary motion of the directional hook, and limits the motion end point of the counterclockwise motion of the directional hook, so that the directional hook clamps the ratchet wheel, the ratchet wheel is prevented from clockwise moving, and the hanging rope can be conveniently wound by the winding wheel in a unidirectional mode.
The invention controls the descending depth and the ascending height of the beaker seat by manually swinging the ratchet wheel, thereby controlling the height of the beaker, the connection relation between all parts is simple, the operation is easy, the rotation motion of the ratchet wheel is limited by the clamping of the directional hook on the ratchet wheel, thereby the height of the beaker is fixed, the disintegration experiment is convenient to carry out, all parts are easy to manufacture and have low cost, the subsequent maintenance cost is low, the maintenance is convenient, and the efficiency is high.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Fig. 2 is a left side view of the invention.
Fig. 3 is a rear view of the present invention.
FIG. 4 is a front view of the beaker cover of the present invention.
Fig. 5 is a top view of the beaker lid of the present invention.
Fig. 6 is a front view of the cartridge of the present invention.
Fig. 7 is a left side view of the cartridge of the present invention.
Fig. 8 is a top view of the cartridge of the present invention.
Fig. 9 is a schematic view of the roller mounting of the present invention.
Figure 10 is a top view of the roller mounting of the present invention.
In the drawings, the corresponding relationship between the component names and the reference numbers is as follows:
1-base, 101-control panel, 102-display screen, 2-box, 201-heater, 202-temperature sensor, 3-support, 301-roller, 4-lifting mechanism, 401-ratchet, 402-reel, 403-directional hook, 404-fixture block, 5-lifting rope, 6-beaker seat, 7-beaker, 701-beaker cover, 702-cutting sleeve.
Detailed Description
The embodiments of the present invention will be described in further detail with reference to the drawings and examples. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
In the description of the present invention, "a plurality" means two or more unless otherwise specified; the terms "upper", "lower", "left", "right", "inner", "outer", "front", "rear", "head", "tail", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are only for convenience in describing and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, should not be construed as limiting the invention. Furthermore, the terms "first," "second," "third," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, e.g., as being fixed or detachable or integrally connected; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example (b):
as shown in figures 1 to 10: a disintegration experiment device for pharmaceutical tablet inspection comprises a base 1, a control panel 101, a display screen 102, a box body 2, a heater 201, a temperature sensor 202, a bracket 3, a roller 301, a lifting mechanism 4, a ratchet wheel 401, a winding wheel 402, a directional hook 403, a fixture block 404, a lifting rope 5, a beaker seat 6, a beaker 7, a beaker cover 701 and a clamping sleeve 702; a microcomputer controller is arranged in the base 1; the control panel 101 is arranged on the front side surface of the base 1; the display screen 102 is arranged on the front side surface of the base 1 and is arranged on the right side of the control panel 101; the box body 2 is placed on the top side surface of the base 1, the top is an opening end, a partition plate is arranged in the middle, the inner space is evenly divided into a left part and a right part, and the middle of the front side surface is provided with scale marks; the heater 201 and the temperature sensor 202 are respectively provided with two parts, are fixed in the box body 2 and are connected with the controller in the base 1; the bracket 3 is a rectangular column, the side surface of the top of the rectangular column is provided with a rectangular opening, the top ends of the front side surfaces of the left end and the right end of the opening are welded with two rectangular sheets, and the two rectangular sheets are arranged on the side surface of the top of the base 1 and on the rear side of the box body 2; the lifting mechanism 4 is composed of a ratchet wheel 401, a reel 402, a directional hook 403 and a fixture block 404, and is connected to the rear side surface of the base 1 at two positions; one end of the lifting rope 5 is connected to the reel 402, and the other end of the lifting rope passes through the two rollers 301 and then is divided into three strands to be fixed on the beaker seat 6; the beaker 7 is placed in the beaker seat 6; the beaker cover 701 is a rubber cover and is fixed on the top of the beaker 7.
Wherein, gyro wheel 301 passes through the breach department of round pin hub connection in 3 stand partial tops of support, and another department passes through between the two rectangular boards of round pin hub connection in 3 tops of support, can be along connecting pin axle and be rotary motion, is convenient for roll, makes lifting rope 5 operation smooth no card pause, and gyro wheel 301 long service life simultaneously, the price is lower, even damage, and the maintenance cost is also less.
Wherein, the ratchet wheel 401 has sixteen ratchets, and is connected on the back side of the base 1 through the pin shaft, and the side of the ratchet wheel 401 is provided with a column, so that the rotation of the ratchet wheel 401 is convenient to shake by hand, and the slant of the ratchets is also convenient for fixing the directional hook 403.
The reel 402 is a round wheel structure with an arc groove on the outer circle, is connected to the rear side face of the base 1 through a pin shaft, is fixed on the same pin shaft between the base 1 and the ratchet wheel 401, and can drive the reel 402 to rotate in the same direction by rotating the ratchet wheel 401.
The directional hook 403 is an arc hook, the bottom end of the directional hook is in the same tooth shape as the ratchet wheel 401, the directional hook is connected to the rear side face of the base 1 through a pin shaft and can rotate around the pin shaft, the downward state is always kept under the action of gravity, meanwhile, a cylinder is arranged on the side face of the directional hook 403, the directional hook plays a role of a balance weight and is convenient for hand operation to lift the directional hook upwards, when the directional hook is lifted, the ratchet wheel 401 can rotate clockwise and anticlockwise, when the directional hook is put down, the steering of the ratchet wheel 401 is limited, the ratchet wheel cannot rotate clockwise, and therefore the height of the beaker 7 is stabilized.
The fixture block 404 is a rectangular step trapezoidal block, the left end face of the fixture block is an arc-shaped face, the radian of the fixture block is the same as that of the directional hook 403, the fixture block is fixed on the rear side face of the base 1 through two screws, the limiting effect of the directional hook 403 is achieved, the ratchet teeth of the ratchet 401 rotating clockwise are clamped on the directional hook 403, the directional hook 403 abuts against the fixture block 404 under the common force of gravity and the rotating force of the ratchet 401, relative rotation is not generated, and therefore the ratchet 401 abuts against.
Wherein, beaker seat 6 is circular fence structure, and there are three round holes at the excircle top for on tying lifting rope 5, be convenient for fixed beaker 7, simultaneously under the effect of three strands of lifting rope 5, form fixedly to beaker 7, prevent that beaker 7 from taking place to incline in beaker seat 6.
The cutting sleeve 702 is a cylindrical leather sheath structure, and has six positions, the six positions are annularly distributed on the bottom side surface of the beaker cover 701 and used for fixing a test tube, and an opening of the test tube can be upwards fixed in the cutting sleeve 701.
The specific use mode and function of the embodiment are as follows:
in the invention, when in operation, a test tube is fixed in the clamping sleeve 702, the beaker cover 701 is fixed on the beaker 7, finally the beaker 7 is fixed on the beaker seat 6, the directional hook 403 is lifted by fingers, the ratchet wheel 401 is slowly and clockwise shaken, the reel 402 rotates along with the directional hook, the lifting rope 5 is pulled to downwards move from the reel 402, the lifting rope 5 passes through the two rollers 301, the lifting rope 5 is pulled by the gravity of the beaker 7, the beaker 7 sinks in the beaker seat 6, when the beaker is placed at the experimental height, the positioning hook 403 is put down, the movement of the ratchet wheel 401 is limited to stop rotating, so that the height of the beaker 7 is fixed, the ratchet wheel 401 is rotated anticlockwise after the experiment, at the moment, the positioning hook 403 cannot limit and block the rotation of the ratchet wheel 401, the lifting rope 5 is wound on the reel 402, the beaker seat 6 is upwards pulled, and the experimental apparatus is cleaned.
The embodiments of the present invention have been presented for purposes of illustration and description, and are not intended to be exhaustive or limited to the invention in the form disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiment was chosen and described in order to best explain the principles of the invention and the practical application, and to enable others of ordinary skill in the art to understand the invention for various embodiments with various modifications as are suited to the particular use contemplated.
Claims (1)
1. A experimental apparatus that disintegrates for inspection of pharmaceutical tablets, its characterized in that: the disintegration experiment device for checking the pharmaceutical tablets comprises a base (1), a control panel (101), a display screen (102), a box body (2), a heater (201), a temperature sensor (202), a support (3), a roller (301), a lifting mechanism (4), a ratchet wheel (401), a reel (402), a directional hook (403), a fixture block (404), a lifting rope (5), a beaker seat (6), a beaker (7), a beaker cover (701) and a clamping sleeve (702); a microcomputer controller is arranged in the base (1); the control panel (101) is arranged on the front side surface of the base (1); the display screen (102) is arranged on the front side surface of the base (1) and is arranged on the right side of the control panel (101); the box body (2) is placed on the top side surface of the base (1), the top is an open end, a partition plate is arranged in the middle, the inner space is evenly divided into a left part and a right part, and the middle of the front side surface is provided with scale marks; the heater (201) and the temperature sensor (202) are respectively provided with two parts, are fixed in the box body (2), and are connected with the controller in the base (1); the support (3) is a rectangular column, a rectangular opening is formed in the side face of the top of the rectangular column, two rectangular sheets are welded to the top ends of the front side faces of the left end and the right end of the opening, and the two rectangular sheets are arranged on the top side face of the base (1) and on the rear side of the box body (2); the lifting mechanism (4) consists of a ratchet wheel (401), a reel (402), a directional hook (403) and a fixture block (404), and is connected to the rear side surface of the base (1) at two positions; one end of the lifting rope (5) is connected to the reel (402), and the other end of the lifting rope penetrates through the two rollers (301) and then is divided into three strands to be fixed on the beaker seat (6); the beaker (7) is placed in the beaker seat (6); the beaker cover (701) is a rubber cover and is fixed at the top of the beaker (7);
the roller (301) is connected to a notch at the top end of the upright column part of the bracket (3) through a pin shaft, and the other position of the roller is connected between two rectangular plates at the top end of the bracket (3) through a pin shaft and can rotate along the connecting pin shaft;
the ratchet wheel (401) is provided with sixteen ratchets and is connected to the rear side face of the base (1) through a pin shaft;
the reel (402) is of a round wheel structure with an arc groove on the excircle, is connected to the rear side surface of the base (1) through a pin shaft, and is arranged between the base (1) and the ratchet wheel (401);
the directional hook (403) is an arc hook, the bottom end of the directional hook is in the same tooth shape as the ratchet wheel (401), the directional hook is connected to the rear side face of the base (1) through a pin shaft and can rotate around the pin shaft, the directional hook is always kept in a downward state under the action of gravity, and meanwhile, a cylinder is arranged on the side face of the directional hook (403);
the fixture block (404) is a rectangular step trapezoidal block, the left end face of the fixture block is an arc-shaped face, the radian of the fixture block is the same as that of the directional hook (403), and the fixture block is fixed on the rear side face of the base (1) through two screws;
the beaker seat (6) is of a circular fence structure, and the top of the outer circle is provided with three circular holes for being tied to the lifting rope (5);
the cutting sleeve (702) is of a cylindrical leather sheath structure, and is annularly distributed on the bottom side surface of the beaker cover (701) at six positions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811257890.9A CN109324162B (en) | 2018-10-26 | 2018-10-26 | A experimental apparatus that disintegrates for inspection of medicine tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811257890.9A CN109324162B (en) | 2018-10-26 | 2018-10-26 | A experimental apparatus that disintegrates for inspection of medicine tablet |
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| CN109324162A CN109324162A (en) | 2019-02-12 |
| CN109324162B true CN109324162B (en) | 2021-09-03 |
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| CN201811257890.9A Active CN109324162B (en) | 2018-10-26 | 2018-10-26 | A experimental apparatus that disintegrates for inspection of medicine tablet |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114527246B (en) * | 2022-02-17 | 2023-07-25 | 深圳中旭生物科技有限公司 | Cardiovascular and cerebrovascular medicine research and development check out test set |
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| CN207366539U (en) * | 2017-10-19 | 2018-05-15 | 广州维奥康药业科技有限公司 | Disintegration tester |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2367473Y (en) * | 1999-04-21 | 2000-03-08 | 蔡文华 | Lifting blackboard |
| US7938032B2 (en) * | 2008-10-30 | 2011-05-10 | Agilent Technologies, Inc. | Dissolution testing with in-situ gravimetric volume measurement |
| CN204057831U (en) * | 2014-07-18 | 2014-12-31 | 国家电网公司 | The portable lifting appliance of cement pole |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19537179C1 (en) * | 1995-10-06 | 1997-04-10 | Loeffler Hans Peter | Device for determining the disintegration time of compressed medicinal tablets, such as tablets and capsules |
| CN2368403Y (en) * | 1999-03-30 | 2000-03-15 | 王学森 | Hand-operated lifting clothes hanger |
| CN103542344B (en) * | 2013-11-15 | 2015-08-19 | 陈冬卉 | Be provided with the pendent lamp of function of auto-lift |
| CN204241466U (en) * | 2014-11-17 | 2015-04-01 | 天津药典标准仪器厂 | A kind of novel intelligent disintegration tester |
| CN205109684U (en) * | 2015-11-18 | 2016-03-30 | 吴桂阳 | Heating device for chemistry experiments |
| CN205913580U (en) * | 2016-04-15 | 2017-02-01 | 重庆市肿瘤研究所 | Linkage is used in infusion |
| CN205698055U (en) * | 2016-04-29 | 2016-11-23 | 中国人民解放军第四军医大学 | A kind of orthopaedics traction sterilization lifting support |
| CN207366539U (en) * | 2017-10-19 | 2018-05-15 | 广州维奥康药业科技有限公司 | Disintegration tester |
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| CN109324162A (en) | 2019-02-12 |
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