CN207946416U

CN207946416U - A kind of chemical stability detection device for fat-soluble medicine

Info

Publication number: CN207946416U
Application number: CN201820359196.7U
Authority: CN
Inventors: 王亚莎
Original assignee: Zhejiang Jiayuda Machinery Co Ltd
Current assignee: Zhejiang Jiayuda Machinery Co Ltd
Priority date: 2018-03-16
Filing date: 2018-03-16
Publication date: 2018-10-09
Anticipated expiration: 2028-03-16

Abstract

The utility model is related to drug detection device technical fields, and disclose a kind of chemical stability detection device for fat-soluble medicine, including holder, the branch intralamellar part of holder has been fixedly attached retort, the top of retort is equipped with capping, the middle part of the middle part of retort inner cavity bottom end and capping bottom end is installed with chassis, the inside on two chassis respectively with the upper and lower ends pivot bush unit of support shaft.This is used for the chemical stability detection device of fat-soluble medicine, rabbling mechanism is driven to be moved back and forth in retort by servo motor, aids drug stirs process in the intraorganic wriggling such as the stomach of human body, so that the external condition of drug test is more nearly the reaction condition of inside of human body, so that measurement result more has authority representative, the corresponding reagent for measuring peroxidating is added to retort by gas-guide tube, the measurement of acidification and peroxide value can be carried out to drug simultaneously, and then the chemical stability of drug is detected.

Description

A kind of chemical stability detection device for fat-soluble medicine

Technical field

The utility model is related to drug detection device technical fields, specially a kind of chemical stabilization for fat-soluble medicine Property detection device.

Background technology

Fat-soluble medicine refers to drug that is not soluble in water and being dissolved in the organic solvents such as fat and carbon tetrachloride, glycerine, grease, Many drugs are all liposoluble substances, cannot be dissolved in water, blood or other body fluid, drug release market before, need through Drug detection is crossed, wherein it is the Physico-chemical tests of drug to need critically important one, i.e., the physics of drug and chemical property are carried out Detection, the fat-soluble water solubility of drug can influence drug absorption, distribution, metabolism and excretion, and chemical stability then influences medicinal substances Amount and physiological disposition.The chemical stability of fat-soluble medicine is detected in the prior art, the equipment index of detection is relatively simple, no Can a multigroup index of measuring apparatus, and be to direct plunge into drug in acid mostly, detect acidity value, set using another The standby peroxide value that measures direct plunges into acid solution since drug is finally to carry out reactive absorption in human body and detects and do not have Very strong representativeness.

Utility model content

（One）The technical issues of solution

In view of the deficiencies of the prior art, the utility model provides a kind of chemical stability detection for fat-soluble medicine Device, have many index measurement function, closer to human body reaction condition, determination data is more representative the advantages that, solve The index of measuring apparatus is single and measurement result does not have very strong representative problem.

（Two）Technical solution

To realize that above-mentioned many index measurement function, the reaction condition of closer human body and determination data are more representative Purpose, the utility model provide the following technical solutions：A kind of chemical stability detection device for fat-soluble medicine, including branch The branch intralamellar part of frame, the holder has been fixedly attached retort, and the top of the retort is equipped with capping, the retort inner cavity The middle part of bottom end and the middle part of capping bottom end are installed with chassis, and the inside on two chassis is upper with support shaft respectively Lower both ends pivot bush unit, the support shaft front from top to bottom successively be equipped with driven shaft, shaft and angular wheel I, it is described from Moving axis and shaft is fixedly attached respectively with one end of rabbling mechanism and pivot bush unit, the outside of the driven shaft and angular wheel I Central shaft be sequentially connected by transmission belt, the angular wheel I is engaged with angular wheel II, II central shaft of the angular wheel One end be fixedly connected with the output shaft of servo motor by shaft coupling, the bottom end of the servo motor is installed with support Plate, the side of the support plate are fixedly connected at the top of top tank structure side with reacting, the top of the reaction top tank structure other side Embedded with fixed block, the inside fixing sleeve of the fixed block is connected to gas-guide tube, and one end of the gas-guide tube extends to retort inner cavity Bottom end, the gas-guide tube is located at one end outside retort and is installed with intake valve, the bottom end of the retort stretch into plus The bottom end of the inner cavity of heat container, the tip contact of the bottom end and holder bottom plate of the heating container, the heating container intracavity is solid Dingan County is equipped with heating tube.

Preferably, the rabbling mechanism includes bull stick, and the top of the bull stick is hinged with shaft, is opened in the middle part of the bull stick Equipped with sliding slot, the internal slide of the sliding slot is connected with sliding block, and the back side of the sliding block is hinged with curved bar, the curved bar it is another One end with driven shaft is held to be fixedly attached, the other end of the bull stick is threaded with Mixing Brush.

Preferably, the length of the curved bar is less than the half of track length and less than the vertical range of driven shaft to shaft.

Preferably, the Mixing Brush is set there are two types of model, and one is the Mixing Brush with bristle, one is without bristles and have The Mixing Brush of brush board.

Preferably, the pivot bush unit mode of the chassis and support shaft is connected using slot form, and chassis top opens up Groove be square groove, the cross sectional shape of the support shaft is square-section.

Preferably, the liquid injected in the heating container is water, and the volume of water is heat container volume 2/3.

（Three）Advantageous effect

Compared with prior art, the utility model provides a kind of chemical stability detection dress for fat-soluble medicine It sets, has following advantageous effect：

1, the chemical stability detection device for being used for fat-soluble medicine drives rabbling mechanism reacting by servo motor It is moved back and forth in tank, aids drug stirs process in the intraorganic wriggling such as the stomach of human body so that the outer strip of drug test Part is more nearly the reaction condition of inside of human body, so that measurement result more has authority representative, passes through gas-guide tube pair The corresponding reagent for measuring peroxidating is added in retort, can carry out the measurement of acidification and peroxide value to drug simultaneously, and then right The chemical stability of drug is detected.

2, chemical stability detection device for being used for fat-soluble medicine, by the way that device drive part is installed in support On axis, the upper and lower side of support shaft is actively socketed on chassis, opens capping, you can support shaft is dismantled, to convenient Cleaning to retort is heated the thermally equivalent, it can be achieved that retort by the way that retort to be placed in the water of heating container, It and then being capable of reaction temperature of the more true aids drug in human body so that determination data is more authoritative, more accurately.

Description of the drawings

FIG. 1 is a schematic structural view of the utility model；

Fig. 2 is the vertical view of the utility model chassis position；

Fig. 3 is the structural schematic diagram of the utility model rabbling mechanism.

In figure：1 holder, 2 retort, 3 cappings, 4 chassis, 5 support shafts, 6 driven shafts, 7 shafts, the stirring of 8 angular wheels I, 9 Mechanism, 91 bull sticks, 92 sliding slots, 93 sliding blocks, 94 curved bars, 95 Mixing Brushes, 10 transmission belts, 11 angular wheels II, 12 shaft couplings, 13 are watched Take motor, 14 support plates, 15 fixed blocks, 16 gas-guide tubes, 17 intake valves, 18 heating containers, 19 heating tubes.

Specific implementation mode

The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work The every other embodiment obtained, shall fall within the protection scope of the present invention.

Please refer to Fig.1-3, a kind of chemical stability detection device for fat-soluble medicine, including holder 1, holder 1 Branch intralamellar part has been fixedly attached retort 2, and the top of retort 2 is equipped with capping 3, middle part and the capping 3 of 2 inner cavity bottom end of retort The middle part of bottom end is installed with chassis 4, the inside on two chassis 4 respectively with the upper and lower ends pivot bush unit of support shaft 5, bottom Disk 4 is connect with the pivot bush unit mode of support shaft 5 using slot form, and the groove that 4 top of chassis opens up is square groove, support The cross sectional shape of axis 5 is square-section can constrain the rotational freedom of support shaft 5, prevent from propping up by the way that square groove is arranged The stability that the rotation of support axis 5 runs device impacts, will by the way that device drive part to be installed in support shaft 5 The upper and lower side of support shaft 5 is actively socketed on chassis 4, opens capping 3, you can is dismantled to support shaft 5, to convenient to anti- The cleaning for answering tank 2, by by retort 2 be placed in heating container 18 water in heated, it can be achieved that retort 2 it is uniform by Heat, and then being capable of reaction temperature of the more true aids drug in human body so that determination data is more authoritative, more accurate Really, the front of support shaft 5 is equipped with driven shaft 6, shaft 7 and angular wheel I 8 successively from top to bottom, and driven shaft 6 and shaft 7 are distinguished It is fixedly attached with one end of rabbling mechanism 9 and pivot bush unit, rabbling mechanism 9 includes bull stick 91, top and the shaft 7 of bull stick 91 are cut with scissors It connects, the middle part of bull stick 91 offers sliding slot 92, and the internal slide of sliding slot 92 is connected with sliding block 93, and the back side of sliding block 93 is hinged with song The length of bar 94, curved bar 94 is less than the half of 92 length of sliding slot and less than the vertical range of driven shaft 6 to shaft 7, ensures stirring Mechanism 9 realizes that the necessary condition that pendulum model moves back and forth, one end of the other end and driven shaft 6 of curved bar 94 are fixedly attached, bull stick 91 other end is threaded with Mixing Brush 95, can Mixing Brush 95 be realized that pendulum model moves back and forth by rabbling mechanism 9, more The organs such as close simulation human stomach stir process, so that determination data more authority and accuracy, Mixing Brush 95 If there are two types of model, one is the Mixing Brush 95 with bristle, one is without bristles and have the Mixing Brush 95 of brush board, pass through stirring Brush 95 is threadedly coupled with bull stick 91, can be convenient for replacing Mixing Brush 95, be replaced not according to the different demands of stirring and cleaning Same Mixing Brush 95, the outside of driven shaft 6 and the central shaft of angular wheel I 8 are sequentially connected by transmission belt 10, angular wheel I 8 It is engaged with angular wheel II 11, one end of II 11 central shaft of angular wheel is solid by the output shaft of shaft coupling 12 and servo motor 13 Fixed connection, the bottom end of servo motor 13 are installed with support plate 14, drive rabbling mechanism 9 in retort by servo motor 13 It is moved back and forth in 2, aids drug stirs process in the intraorganic wriggling such as the stomach of human body so that the external condition of drug test It is more nearly the reaction condition of inside of human body, so that measurement result more has authority representative, the side of support plate 14 It is fixedly connected at the top of 2 inner wall side of retort, the top of the 2 inner wall other side of retort is embedded with fixed block 15, fixed block 15 Inside fixing sleeve be connected to gas-guide tube 16, one end of gas-guide tube 16 extends to the bottom end of 2 inner cavity of retort, right by gas-guide tube 16 The corresponding reagent for measuring peroxidating is added in retort 2, can carry out the measurement of acidification and peroxide value to drug simultaneously, and then right The chemical stability of drug is detected, and gas-guide tube 16 is located at one end outside retort 2 and is installed with intake valve 17, reaction The inner cavity of heating container 18 is stretched into the bottom end of tank 2, and it is water to heat the liquid injected in container 18, and the volume of water is heating container The 2/3 of 18 volumes heats retort 2 by heating water, it is ensured that the thermally equivalent of retort 2, preferably control is anti- The temperature value in tank 2 is answered, the tip contact of the bottom end and 1 bottom plate of holder of container 18 is heated, the bottom end of 18 inner cavity of heating container is solid Dingan County is equipped with heating tube 19.

When work, by drug to be checked and corresponding acid solution input retort 2, device, and fixed capping 3 is installed, is led to Electric heating tube 19 heats the water in heating container 18, when being heated to 37 ° or so, starts servo motor 13, passes through taper The rotation of gear I 8 drives angular wheel II 11 to rotate, to drive driven shaft 6 to turn in the front of support shaft 5 by transmission belt 10 Dynamic, to drive curved bar 94 to be rotated around driven shaft 6, curved bar 94 rotates so that sliding block 93 is in the interior sliding of sliding slot 92, while pushing and turning 7 rotation around the shaft of bar 91, when sliding block 93, which is moved to, is total to horizontal plane with driven shaft 6, is rotated further driven shaft 6, sliding block 93 is in cunning Slot 92 continues to slide, and bull stick 91 is retracted, to which Mixing Brush 95 is realized that pendulum model moves back and forth, to anti-in retort 2 It answers object to carry out reciprocating stirring, when needing to carry out peroxidating detection, opens intake valve 17, peroxide is added by gas-guide tube 16 Change detection reagent, after terminating to detect, arrestment operating opens capping 3, picks up support shaft 6, back out the fixed servo of screw Motor 13, you can retort 2 is cleared up.

In conclusion this is used for the chemical stability detection device of fat-soluble medicine, is driven and stirred by servo motor 13 Mechanism 9 moves back and forth in retort 2, and aids drug stirs process in the intraorganic wriggling such as the stomach of human body so that drug The external condition of detection is more nearly the reaction condition of inside of human body, so that measurement result more has authority representative, The corresponding reagent for measuring peroxidating is added to retort 2 by gas-guide tube 16, can acidification and peroxidating be carried out to drug simultaneously The measurement of value, and then the chemical stability of drug is detected；By the way that device drive part is installed in support shaft 5, The upper and lower side of support shaft 5 is actively socketed on chassis 4, capping 3 is opened, you can support shaft 5 is dismantled, to convenient pair The cleaning of retort 2, by by retort 2 be placed in heating container 18 water in heated, it can be achieved that retort 2 it is uniform by Heat, and then being capable of reaction temperature of the more true aids drug in human body so that determination data is more authoritative, more accurate Really；Solve the problems, such as that the index of measuring apparatus is single and measurement result do not have it is very strong representative.

It should be noted that herein, relational terms such as first and second and the like are used merely to a reality Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those Element, but also include other elements that are not explicitly listed, or further include for this process, method, article or equipment Intrinsic element.

While there has been shown and described that the embodiments of the present invention, for the ordinary skill in the art, It is appreciated that can these embodiments be carried out with a variety of variations in the case where not departing from the principles of the present invention and spirit, repaiied Change, replace and modification, the scope of the utility model are defined by the appended claims and the equivalents thereof.

Claims

1. a kind of chemical stability detection device for fat-soluble medicine, including holder（1）, it is characterised in that：The holder （1）Branch intralamellar part be fixedly attached retort（2）, the retort（2）Top be equipped with capping（3）, the retort（2） The middle part of inner cavity bottom end and capping（3）The middle part of bottom end is installed with chassis（4）, two chassis（4）Inside points Not and support shaft（5）Upper and lower ends pivot bush unit, the support shaft（5）Front from top to bottom successively be equipped with driven shaft（6）、 Shaft（7）With angular wheel I（8）, the driven shaft（6）And shaft（7）Respectively with rabbling mechanism（9）One end be fixedly attached and Pivot bush unit, the driven shaft（6）Outside and angular wheel I（8）Central shaft pass through transmission belt（10）It is sequentially connected, it is described Angular wheel I（8）With angular wheel II（11）Engagement, the angular wheel II（11）One end of central shaft passes through shaft coupling（12） With servo motor（13）Output shaft be fixedly connected, the servo motor（13）Bottom end be installed with support plate（14）, institute State support plate（14）Side and retort（2）Inner wall is fixedly connected at the top of side, the retort（2）The inner wall other side Top is embedded with fixed block（15）, the fixed block（15）Inside fixing sleeve be connected to gas-guide tube（16）, the gas-guide tube（16）'s One end extends to retort（2）The bottom end of inner cavity, the gas-guide tube（16）Positioned at retort（2）External one end is installed with Intake valve（17）, the retort（2）Bottom end stretch into heating container（18）Inner cavity, the heating container（18）Bottom end with Holder（1）The tip contact of bottom plate, the heating container（18）The bottom end of inner cavity is installed with heating tube（19）.

2. a kind of chemical stability detection device for fat-soluble medicine according to claim 1, it is characterised in that：Institute State rabbling mechanism（9）Including bull stick（91）, the bull stick（91）Top and shaft（7）It is hinged, the bull stick（91）Middle part Offer sliding slot（92）, the sliding slot（92）Internal slide be connected with sliding block（93）, the sliding block（93）The back side be hinged with Curved bar（94）, the curved bar（94）The other end and driven shaft（6）One end be fixedly attached, the bull stick（91）Other end spiral shell Line is connected with Mixing Brush（95）.

3. a kind of chemical stability detection device for fat-soluble medicine according to claim 2, it is characterised in that：Institute State curved bar（94）Length be less than sliding slot（92）The half of length and be less than driven shaft（6）To shaft（7）Vertical range.

4. a kind of chemical stability detection device for fat-soluble medicine according to claim 2, it is characterised in that：Institute State Mixing Brush（95）If there are two types of models, one is the Mixing Brushes with bristle（95）, one is without bristles and have stirring for brush board Mix brush（95）.

5. a kind of chemical stability detection device for fat-soluble medicine according to claim 1, it is characterised in that：Institute State chassis（4）With support shaft（5）Pivot bush unit mode connected using slot form, and chassis（4）The groove that top opens up is Square groove, the support shaft（5）Cross sectional shape be square-section.

6. a kind of chemical stability detection device for fat-soluble medicine according to claim 1, it is characterised in that：Institute State heating container（18）The liquid of middle injection is water, and the volume of water is heating container（18）The 2/3 of volume.